proflavine

Summary

Summary: 3,6-Diaminoacridine. Topical antiseptic used mainly in wound dressings.

Top Publications

  1. ncbi Synthesis and DNA interaction of a mixed proflavine-phenanthroline Tröger base
    Brigitte Baldeyrou
    INSERM U 524 et Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, Institut de Recherches sur le Cancer, Place de Verdun, F 59045 Lille, France
    Eur J Med Chem 37:315-22. 2002
  2. ncbi A randomized study of 3 umbilical cord care regimens at home in thai neonates: comparison of time to umbilical cord separation, parental satisfaction and bacterial colonization
    Sangkae Chamnanvanakij
    Department of Pediatrics, Phramongkutklao Hospital, 315 Rajavithee Rd, Bangkok 10400, Thailand
    J Med Assoc Thai 88:967-72. 2005
  3. ncbi Synthesis, DNA interaction, and cytotoxic activity of a novel proflavine-dithiazolidinone pharmacophore
    Ladislav Janovec
    Department of Organic Chemistry, Institute of Chemistry, Faculty of Science, P J Safarik University, Moyzesova 11, SK 04167 Kosice, Slovak Republic
    Bioconjug Chem 18:93-100. 2007
  4. ncbi Visible light-driven NADH regeneration sensitized by proflavine for biocatalysis
    Dong Heon Nam
    KAIST Institute for the Biocentury, Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology KAIST, 335 Science Road, Daejeon 305 701, South Korea
    Chembiochem 13:1278-82. 2012
  5. ncbi Physical nature of ethidium and proflavine interactions with nucleic acid bases in the intercalation plane
    Karol M Langner
    Wroclaw University of Technology, Wyb Wyspianskiego 27, 50 370 Wroclaw, Poland
    J Phys Chem B 110:9720-7. 2006
  6. ncbi Electrochemical and spectroscopic studies of the interaction of proflavine with DNA
    Mehmet Aslanoglu
    Department of Chemistry, University of Harran, Sanliurfa, Turkey
    Anal Sci 22:439-43. 2006
  7. ncbi Relaxation kinetics of the interaction between RNA and metal-intercalators: the Poly(A).Poly(U)/platinum-proflavine system
    Tarita Biver
    Dipartimento di Chimica e Chimica Industriale, , Via Risorgimento 35, 56126 Pisa, Italy
    Arch Biochem Biophys 437:215-23. 2005
  8. ncbi Role of the third strand in the binding of proflavine and pt-proflavine to poly(rA).2poly(rU): a thermodynamic and kinetic study
    Begoña García
    Departamento de Quimica, Universidad de Burgos, 09001 Burgos, Spain
    J Phys Chem B 112:7132-9. 2008
  9. ncbi Cytotoxic activity of proflavine diureas: synthesis, antitumor, evaluation and DNA binding properties of 1',1''-(acridin-3,6-diyl)-3',3''-dialkyldiureas
    Maria Kozurkova
    Department of Biochemistry, Institute of Chemistry, Faculty of Science, P J Safarik University, SK 04167 Kosice, Slovakia
    Bioorg Med Chem 16:3976-84. 2008
  10. ncbi Synthesis and antileishmanial activity of 6-mono-substituted and 3,6-di-substituted acridines obtained by acylation of proflavine
    Carole Di Giorgio
    Laboratoire de Parasitologie, Hygiene et Zoologie, Faculte de Pharmacie, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Eur J Med Chem 42:1277-84. 2007

Research Grants

Scientific Experts

Detail Information

Publications122 found, 100 shown here

  1. ncbi Synthesis and DNA interaction of a mixed proflavine-phenanthroline Tröger base
    Brigitte Baldeyrou
    INSERM U 524 et Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, Institut de Recherches sur le Cancer, Place de Verdun, F 59045 Lille, France
    Eur J Med Chem 37:315-22. 2002
    ..the synthesis of an asymmetric Tröger base containing the two well characterised DNA binding chromophores, proflavine and phenanthroline...
  2. ncbi A randomized study of 3 umbilical cord care regimens at home in thai neonates: comparison of time to umbilical cord separation, parental satisfaction and bacterial colonization
    Sangkae Chamnanvanakij
    Department of Pediatrics, Phramongkutklao Hospital, 315 Rajavithee Rd, Bangkok 10400, Thailand
    J Med Assoc Thai 88:967-72. 2005
    ..To compare time to cord separation, parental satisfaction and bacterial colonization, among 3 regimens of cord care at home...
  3. ncbi Synthesis, DNA interaction, and cytotoxic activity of a novel proflavine-dithiazolidinone pharmacophore
    Ladislav Janovec
    Department of Organic Chemistry, Institute of Chemistry, Faculty of Science, P J Safarik University, Moyzesova 11, SK 04167 Kosice, Slovak Republic
    Bioconjug Chem 18:93-100. 2007
    Five novel proflavine-dithiazolidinone derivatives 4a-4e have been designed and synthesized by the reaction of dialkyl acridin-3,6-diyl dithioureas 3a-3e with methyl bromoacetate...
  4. ncbi Visible light-driven NADH regeneration sensitized by proflavine for biocatalysis
    Dong Heon Nam
    KAIST Institute for the Biocentury, Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology KAIST, 335 Science Road, Daejeon 305 701, South Korea
    Chembiochem 13:1278-82. 2012
    Harvest time: Proflavine drives the reduction of NAD(+) in the presence of a Rh-based electron mediator...
  5. ncbi Physical nature of ethidium and proflavine interactions with nucleic acid bases in the intercalation plane
    Karol M Langner
    Wroclaw University of Technology, Wyb Wyspianskiego 27, 50 370 Wroclaw, Poland
    J Phys Chem B 110:9720-7. 2006
    ..basis of the crystallographic structures of three nucleic acid intercalation complexes involving ethidium and proflavine, we have analyzed the interaction energies between intercalator chromophores and their four nearest bases, using ..
  6. ncbi Electrochemical and spectroscopic studies of the interaction of proflavine with DNA
    Mehmet Aslanoglu
    Department of Chemistry, University of Harran, Sanliurfa, Turkey
    Anal Sci 22:439-43. 2006
    The interaction of proflavine with herring sperm DNA has been investigated by cyclic voltammetry and UV-Vis spectroscopy as well as viscosity measurements...
  7. ncbi Relaxation kinetics of the interaction between RNA and metal-intercalators: the Poly(A).Poly(U)/platinum-proflavine system
    Tarita Biver
    Dipartimento di Chimica e Chimica Industriale, , Via Risorgimento 35, 56126 Pisa, Italy
    Arch Biochem Biophys 437:215-23. 2005
    The interactions of Poly(A).Poly(U) with the cis-platinum derivative of proflavine [{PtCl(tmen)}(2){HNC(13)H(7)(NHCH(2)CH(2))(2)}](+) (PRPt) and proflavine (PR) are investigated by spectrophotometry, spectrofluorimetry and T-jump ..
  8. ncbi Role of the third strand in the binding of proflavine and pt-proflavine to poly(rA).2poly(rU): a thermodynamic and kinetic study
    Begoña García
    Departamento de Quimica, Universidad de Burgos, 09001 Burgos, Spain
    J Phys Chem B 112:7132-9. 2008
    The interactions of triple strands of poly(rA).2poly(rU) with proflavine (PR) and the proflavine cis-platinum derivative [{PtCl (tmen)} 2{NC 13H 7(NCH 2CH 2) 2}] (+) (PRPt) are examined at pH 7.0, T = 25 degrees C, and 0...
  9. ncbi Cytotoxic activity of proflavine diureas: synthesis, antitumor, evaluation and DNA binding properties of 1',1''-(acridin-3,6-diyl)-3',3''-dialkyldiureas
    Maria Kozurkova
    Department of Biochemistry, Institute of Chemistry, Faculty of Science, P J Safarik University, SK 04167 Kosice, Slovakia
    Bioorg Med Chem 16:3976-84. 2008
    ..From spectrofluorimetric titrations, binding constants for the DNA-drug complexes were determined (K=0.9-4.2x10(5) M(-1)). Antiproliferative activity of synthesized derivatives might be related to their intercalation into DNA...
  10. ncbi Synthesis and antileishmanial activity of 6-mono-substituted and 3,6-di-substituted acridines obtained by acylation of proflavine
    Carole Di Giorgio
    Laboratoire de Parasitologie, Hygiene et Zoologie, Faculte de Pharmacie, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Eur J Med Chem 42:1277-84. 2007
    Two new series of diaminoacridinic derivatives obtained from proflavine and N-(6-amino-3-acridinyl)acetamide were synthesised and assessed for their cytotoxic and antileishmanial activities...
  11. ncbi Ethidium and proflavine binding to a 2',5'-linked RNA duplex
    Eric D Horowitz
    School of Chemistry and Biochemistry, Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332 0400, USA
    J Am Chem Soc 128:15380-1. 2006
    ..Fluorescence titrations were used to determine the association constants of two known intercalators, proflavine and ethidium, for duplex 2',5'-linked RNA...
  12. ncbi Fluorescence of acridinic dyes in anionic surfactant solution
    Robson Valentim Pereira
    Instituto de Quimica de Sao Carlos, Universidade de Sao Paulo, Fisico Quimica, Av Trabalhador So Carlense 400, São Carlos 13566590, SP, Brazil
    Spectrochim Acta A Mol Biomol Spectrosc 61:2926-32. 2005
    The interaction of the cationic dyes acridine, 9-aminoacridine (9AA), and proflavine, with sodium dodecyl sulfate (SDS) was studied by electronic absorption, steady-state and time-resolved fluorescence spectroscopies...
  13. ncbi On the origin of the decrease in stability of the DNA hairpin d(GCGAAGC) on complexation with aromatic drugs
    V V Kostjukov
    Department of Physics, Sevastopol National Technical University, Studgorodok, Sevastopol, 99053, Crimea, Ukraine
    Biophys Chem 129:56-9. 2007
    ..the DNA hairpin d(GCGAAGC) on binding the aromatic drug molecules, daunomycin, ethidium bromide, novantrone and proflavine. This complexation behavior is in contrast to the stabilizing effect of the same aromatic drug molecules on DNA ..
  14. ncbi Dialysis cells for controlled DNA: drug binding studies
    K J Sanders
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Analyst 126:852-4. 2001
    An efficient small volume accurate dialysis system has been designed, built and tested for proflavine binding to DNA based upon the side by side design used in the Franz diffusion cell...
  15. ncbi Assembly of an antiparallel homo-adenine DNA duplex by small-molecule binding
    Ozgül Persil
    School of Chemistry and Biochemistry, Parker H Petit Institute of Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia 30332 0400, USA
    J Am Chem Soc 126:8644-5. 2004
    ..These observations illustrate that the helical structure of the homo-adenine-coralyne duplex is compatible with the B-form DNA helix...
  16. ncbi Putative identification of functional interactions between DNA intercalating agents and topoisomerase II using the V79 in vitro micronucleus assay
    Ronald D Snyder
    DuPont Pharmaceuticals Company, Stine Haskell Research Center, P O Box 50, H1 1710, Newark, DE 19714, USA
    Mutat Res 503:21-35. 2002
    ..g. chloroquine (CHL), tacrine (TAC), 9-aminoacridine (9AA), ethidium bromide (EB)) or topo II poisons (e.g. proflavine (PROF), auramine O (AUR) and curcumin (CURC))...
  17. ncbi Hetero-association of caffeine and aromatic drugs and their competitive binding with a DNA oligomer
    D B Davies
    School of Biological and Chemical Sciences, Birkbeck College, University of London, UK
    Eur Biophys J 30:354-66. 2001
    ..action of caffeine (CAF) on the complexation with DNA of mutagens such as ethidium bromide, propidium iodide, proflavine and acridine orange, and anticancer drugs such as actinomycin D and daunomycin...
  18. ncbi Intercalation model for DNA-cross linking in a 1-nitro-9-aminoacridine derivative, an analog of the antitumor agent "ledakrin" (nitracrine)
    W C Stallings
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111
    J Biomol Struct Dyn 2:511-24. 1984
    ..that functional groups on C-829 or C-283 are, when the acridine portion of the molecule is intercalated as in a proflavine dinucleoside phosphate complex, in positions suitable for DNA cross-linking by activated 1-nitro-9-aminoacridine ..
  19. pmc Kinetically competent intermediates in the translocation step of protein synthesis
    Dongli Pan
    Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Cell 25:519-29. 2007
    ..GTP-induced conformational changes...
  20. ncbi Magnetic field effect corroborated with docking study to explore photoinduced electron transfer in drug-protein interaction
    Brotati Chakraborty
    Chemical Sciences Division, Saha Institute of Nuclear Physics, 1 AF Bidhannagar, Kolkata 700064, India
    J Phys Chem A 114:13313-25. 2010
    ..A prominent MF effect is observed in homogeneous buffer medium owing to the pseudoconfinement of the radicals/radical ions provided by the complex structure of the protein...
  21. ncbi A randomised controlled trial of a double layer of Allevyn compared to Jellonet and proflavin as a tie-over dressing for small skin grafts
    D Atherton
    Plastic Surgery Department, St Andrew s Centre for Plastic Surgery, Broomfield Hospital, Chelmsford, Essex CM1 7ET, UK
    J Plast Reconstr Aesthet Surg 61:535-9. 2008
    ..Various materials have been proposed, however we have compared one of the most popular, Jellonet with a bolster of proflavin-soaked cotton wool, to a newer dressing, Allevyn foam...
  22. ncbi Catalytic properties of monoamine oxidase from the lamprey Lampetrafluviatilis liver
    O V Yagodina
    Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr Morisa Toreza 44, St Petersburg, 194223 Russia
    Dokl Biochem Biophys 410:270-2. 2006
  23. ncbi Conformational dynamics at the active site of alpha-chymotrypsin and enzymatic activity
    Debapriya Banerjee
    Unit for Nano Science and Technology, Department of Chemical, Biological and Macromolecular Sciences, S N Bose National Centre For Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata 700 098, India
    Langmuir 24:8163-8. 2008
    ..We have also proposed the possible implications of the dynamics in the associated energetics...
  24. pmc Complexation of biologically active aromatic compounds with DNA in the presence of theophylline
    A A Hernandez Santiago
    Faculty of Chemical Sciences, Autonomous University of Puebla, Puebla, Mexico
    J Biol Phys 35:115-26. 2009
    ..THP) with various biologically active aromatic compounds (daunomycin, novantrone, ethidium bromide, proflavine, norfloxacin) and the complexation constants of THP with both single- and double-stranded oligonucleotides in ..
  25. ncbi A biochemical logic gate using an enzyme and its inhibitor. 1. The inhibitor as switching element
    S Sivan
    The Leonard and Diane Sherman Center for Research in Biomaterials, Department of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa 32000, Israel
    Biotechnol Prog 15:964-70. 1999
    ..is given to the experimental conditions-particularly the irradiation mode-that affect the performance of proflavine as inhibitor of alpha-chymotrypsin...
  26. ncbi Proflavine-mediated inactivation of Salmonella dublin exposed to visible sunlight in natural fresh water
    V K Kussovski
    Institute of Microbiology, Bulgarian Academy of Sciences, Sofia
    Microbios 105:119-25. 2001
    ..sunlight, and heterotrophic bacteria in freshwater microcosms in the presence and absence of the photosensitizer proflavine, was studied. Enumeration of S...
  27. ncbi The nature of the force-induced conformation transition of dsDNA studied by using single molecule force spectroscopy
    Ningning Liu
    State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, PR China
    Langmuir 26:9491-6. 2010
    ..Furthermore, the effect of proflavine, a DNA intercalator, on the SSB-DNA interactions has been investigated, and the results indicate that the ..
  28. ncbi Antibacterial efficacy of acridine derivatives conjugated with gold nanoparticles
    Piyali Mitra
    Chemical Sciences Division, Saha Institute of Nuclear Physics, 1 AF, Bidhannagar, Kolkata 700064, India
    Int J Pharm 473:636-43. 2014
    ..9-aminoacridine hydrochloride hydrate (9AA-HCl), acridine yellow (AY), acridine orange (AO), and proflavine (Pro) on citrate stabilized gold nanoparticle surface were studied using different analytical techniques like UV-..
  29. ncbi Rapid CE-UV binding tests of environmentally hazardous compounds with polymer-modified magnetic nanoparticles
    Zafar Iqbal
    Ottawa Carleton Chemistry Institute, Department of Chemistry, Carleton University, Ottawa, ON, Canada
    Electrophoresis 32:2181-7. 2011
    ..glycol dimethacrylate submicron particles were investigated for their fast binding kinetics with bisphenol A, proflavine, naphthalene acetic acid, and Escherichia coli...
  30. ncbi Effect of various intercalators on the fenton-type oxidative cleavage of double-stranded DNA
    Hyeon Jeong Kim
    Department of Chemistry, Yeungnam University, Dae Dong, Gyeongsan City, Gyeong buk, 712 749 Republic of Korea, Fax 82 53 815 5412
    Chem Asian J 9:1341-8. 2014
    ..The presence of an intercalator, including ethidium, propidium, 9-aminoacridine, and proflavine, inhibited the first step of the cleavage reaction...
  31. ncbi Studies on the interactions of 3,6-diaminoacridine derivatives with human serum albumin by fluorescence spectroscopy
    Elmas Gökoğlu
    Department of Chemistry, Hacettepe University, Ankara, Turkey
    Luminescence 29:872-7. 2014
    ..and investigation of the modes of binding of the two symmetric 3,6-diaminoacridine derivatives obtained from proflavine, which are 3,6-diphenoxycarbonyl aminoacridine and 3,6-diethoxycarbonyl aminoacridine to human serum albumin (..
  32. ncbi Spectroscopic and thermodynamic insights into the interaction between proflavine and human telomeric G-quadruplex DNA
    Vivek Kumar
    Department of Chemistry, Indian Institute of Science Education and Research IISER Pune, Pune 411008, Maharashtra India
    J Phys Chem B 118:11090-9. 2014
    ..Herein, we probe G-quadruplex and proflavine (a well-known DNA intercalator, hence acting as an anticarcinogen) association through steady state and time-..
  33. ncbi Integrated micro-endoscopy system for simultaneous fluorescence and optical-resolution photoacoustic imaging
    Peng Shao
    University of Alberta, Department of Electrical and Computer Engineering, Edmonton, Alberta, T6G 2V4, Canada
    J Biomed Opt 17:076024. 2012
    ..5-nm-centered diode laser as the light source, an objective lens, and a CCD camera. Proflavine is used as the fluorescent contrast agent by topical application...
  34. ncbi Spectroscopic study of proflavine adsorption on the carbon nanotube surface
    Anatoly S Buchelnikov
    Sevastopol National Technical University, Department of Physics, 33 Universitetskaya Str, Sevastopol 99053 Ukraine
    Appl Spectrosc 68:232-7. 2014
    ..The present paper sheds light on one of the possible mechanisms of interaction between the typical aromatic dye proflavine and the carbon nanotube surface, namely, π-stacking between aromatic rings of these compounds...
  35. ncbi High-resolution microendoscope images of middle ear cholesteatoma and surrounding tissue: evaluation of interobserver concordance
    James Bradley
    Department of Otolaryngology Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Otolaryngol Head Neck Surg 150:654-8. 2014
    ..Investigate how accurately otolaryngologists could differentiate between images obtained with high-resolution microendoscopy (HRME) of ex vivo cholesteatoma specimens and surrounding middle ear epithelium...
  36. doi Development of an analytical approach to study a three-component hetero-association by means of spectrophotometry
    Anatoly S Buchelnikov
    Department of Physics, Sevastopol National Technical University, Sevastopol, 99053, Ukraine
    Appl Spectrosc 67:29-35. 2013
    ..The numerical test of the 1:m:n model, accomplished with the aid of ultraviolet-visible light experimental data in a three-component system (proflavine-caffeine-nicotinamide), proved the validity of the developed approach.
  37. ncbi DNA binding by a new metallointercalator that contains a proflavine group bearing a hanging chelating unit
    Carla Bazzicalupi
    Dipartimento di Chimica, Universita di Firenze, Via della Lastruccia 3, 50019, Sesto Fiorentino, Italy
    Chemistry 14:184-96. 2008
    ..The binding mode at high P/D values corresponds to intercalation of the proflavine residue...
  38. ncbi Stacking interactions and DNA intercalation
    Shen Li
    Department of Physics and Astronomy, Rutgers University, Piscataway, New Jersey 08854 8019, USA
    J Phys Chem B 113:11166-72. 2009
    The relationship between stacking interactions and the intercalation of proflavine and ellipticine within DNA is investigated using a nonempirical van der Waals density functional for the correlation energy...
  39. ncbi Micellar-mediated binding interaction between proflavine hemisulfate and salicylic acid: spectroscopic insights and its analytical application
    Dhanshri T Patil
    Fluorescence Spectroscopy Research Laboratory, Department of Chemistry, Shivaji University, Kolhapur, India
    Luminescence 28:821-6. 2013
    ..in the absorption spectra of SA in the presence of PF indicate a ground state interaction between salicylate and proflavine hemisulfate ions to form a complex...
  40. ncbi DNA binding of a proflavine derivative bearing a platinum hanging residue
    Silvia Biagini
    Dipartimento di Chimica Ugo Schiff, Universita di Firenze, Via della Lastruccia 3, Sesto Fiorentino, Italy
    J Inorg Biochem 105:558-62. 2011
    ..residue external to the base pairs, while at high P/D values the binding corresponds to intercalation of the proflavine residue...
  41. ncbi Molecular mechanism of direct proflavine-DNA intercalation: evidence for drug-induced minimum base-stacking penalty pathway
    Wilbee D Sasikala
    Chemistry Department, Indian Institute of Science Education and Research, Pune 411021, India
    J Phys Chem B 116:12208-12. 2012
    ..surface of direct intercalation from minor groove-bound state for the first time using an anticancer agent proflavine. Mechanism along the minimum free energy path reveals that intercalation happens through a minimum base stacking ..
  42. ncbi "Weighing" photon energies with mass spectrometry: effects of water on ion fluorescence
    William A Donald
    Department of Chemistry, University of California, Berkeley, California 94720 1460 and Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720 8176
    J Am Chem Soc 132:6904-5. 2010
    ..Absorption of a 248 nm photon by hydrated protonated proflavine, PH(+)(H(2)O)(n) (n = 13-50), results in two resolved product ion distributions that correspond to full internal ..
  43. ncbi A C-di-GMP-proflavine-hemin supramolecular complex has peroxidase activity--implication for a simple colorimetric detection
    Shizuka Nakayama
    Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA
    Mol Biosyst 8:726-9. 2012
    ..Herein, we demonstrate that the bacterial signaling molecule, c-di-GMP, can enhance the peroxidation of hemin when proflavine is present...
  44. ncbi Management of ventral hernia after giant exomphalos with external pressure compression using helmet device
    V P Mali
    Department of Paediatric Surgery, National University Hospital, Singapore
    J Pediatr Surg 39:e1-4. 2004
    ..The aim of this study was to evaluate an alternative technique of reducing a ventral hernia that follows the primary conservative treatment of a giant omphalocoele...
  45. pmc A fluorescence stopped-flow kinetic study of the conformational activation of alpha-chymotrypsin and several mutants
    Gert Verheyden
    Laboratory of Biomolecular Dynamics, Katholieke Universiteit Leuven, Celestijnenlaan 200D, B 3001 Leuven, Belgium
    Protein Sci 13:2533-40. 2004
    ..For some mutants our assumptions were not correct, and therefore additional modeling studies of the activation pathways of these mutant proteins are necessary to be able to explain the observed kinetic behavior...
  46. ncbi The Staphylococcus qacH gene product: a new member of the SMR family encoding multidrug resistance
    E Heir
    MATFORSK, Norwegian Food Research Institute, As, Norway
    FEMS Microbiol Lett 163:49-56. 1998
    ..QacH also conferred high-level ethidium bromide resistance and low-level proflavine resistance and thus differed phenotypically from the similar proteins Smr and QacG...
  47. ncbi [Control of staphylococcal skin infections in a nursery]
    F Y Huang
    Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan, R O C
    Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 32:165-70. 1991
    ....
  48. ncbi [Biofilm disclosing agents in complete denture: clinical and antimicrobial evaluation]
    Cláudia Helena Lovato da Silva
    Departamento de Materiais Dentarios e Protese, Faculdade de Odontologia de Ribeirao Preto, Universidade de Sao Paulo, Brasil
    Pesqui Odontol Bras 16:270-5. 2002
    ..One percent eosin, 5% erythrosin, 1% sodic fluorescein, 0.3% proflavine, Replak and 1% neutral red presented no antimicrobial effect...
  49. ncbi Effects of anticancer drugs on transcription in vitro
    D Wilmanska
    Department of General Chemistry, Institute of Physiology and Biochemistry, Medical University of Lodz, Poland
    Z Naturforsch C 56:886-91. 2001
    ..Intercalating ligands which form quickly dissociating complexes with DNA (anthracyclines, proflavine, ethidium bromide) are compared with the slowly dissociating drug of d(G x C) specificity (actinomycin D), the ..
  50. pmc Structural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein
    Maria A Schumacher
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97201 3098, USA
    EMBO J 23:2923-30. 2004
    ..The principles for simultaneous binding of two different drugs discerned here are likely employed by the multidrug efflux transporters...
  51. pmc Achromatized endomicroscope objective for optical biopsy
    Matthew Kyrish
    Department of Bioengineering, Rice University, 6100 Main St, Houston, TX 77005, USA
    Biomed Opt Express 4:287-97. 2013
    ..illumination through the objective while capturing fluorescence images of breast carcinoma cells stained with proflavine and cresyl violet...
  52. ncbi DNA sensing by a Eu-binding peptide containing a proflavine unit
    Laetitia Ancel
    INAC, Service de Chimie Inorganique et Biologique UMR_E 3 CEA UJF, Commissariat a l Energie Atomique, 17 rue des Martyrs, 38054 Grenoble Cedex, France
    Inorg Chem 52:552-4. 2013
    Synthesis of a lanthanide-binding peptide (LBP) for the detection of double-stranded DNA is presented. A proflavine moiety was introduced into a high affinity LBP involving two unnatural chelating amino acids in the Ln ion coordination...
  53. ncbi Ultrafast photoinduced dynamics of the 3,6-diaminoacridinium derivative ATTO 465 in solution
    Jutta Arden-Jacob
    Universitat Siegen, Physikalische Chemie, Adolf Reichwein Str 2, 57076 Siegen, Germany
    Phys Chem Chem Phys 15:1844-53. 2013
    ..An additional ~16 ps component in water, visible over the entire spectral range, is tentatively ascribed to a fast IC channel which is accessed by a fraction of ATTO 465 molecules...
  54. ncbi Intercalation and de-intercalation pathway of proflavine through the minor and major grooves of DNA: roles of water and entropy
    Wilbee D Sasikala
    Department of Chemistry, Indian Institute of Science Education and Research, Pune, Maharashtra 411021, India
    Phys Chem Chem Phys 15:6446-55. 2013
    ..In the intercalated state, an alternate orientation of proflavine is found with an almost equal stability compared to the crystal orientation, however, separated by a 5...
  55. ncbi Attempt to develop live attenuated bacterial vaccines by selecting resistance to gossypol, proflavine hemisulfate, novobiocin, or ciprofloxacin
    Julia W Pridgeon
    Aquatic Animal Health Research Unit, USDA ARS, 990 Wire Road, Auburn, AL 36832, United States
    Vaccine 31:2222-30. 2013
    In an attempt to develop attenuated bacteria as potential live vaccines, four chemicals (gossypol, proflavine hemisulfate, novobiocin, and ciprofloxacin) were used to modify the following four genera of bacteria through chemical-..
  56. pmc Infusion of imaging and therapeutic molecules into the plant virus-based carrier cowpea mosaic virus: cargo-loading and delivery
    Ibrahim Yildiz
    Department of Biomedical Engineering, Case Western Reserve University, Schools of Medicine and Engineering, 10900 Euclid Avenue, Cleveland 44106, USA
    J Control Release 172:568-78. 2013
    ..and acridine orange (3,6-bis(dimethylamino)acridinium chloride), as well as 140 copies of therapeutic payload proflavine (PF, acridine-3,6-diamine hydrochloride), is reported...
  57. ncbi Kinetic and thermodynamic hysteresis imposed by intercalation of proflavine in ferrocene-modified double-stranded DNA
    Magdalena Gebala
    Analytische Chemie Elektroanalytik and Sensorik, Ruhr Universitat Bochum, Universitatsstr 150, D 44780 Bochum, Germany
    Chemphyschem 14:2208-16. 2013
    ..to the ion transport along the DNA strands, a phenomenon which is modulated upon specific intercalation of proflavine into surface-bound dsDNA...
  58. ncbi Subcellular localization of proflavine derivative and induction of oxidative stress--in vitro studies
    Z Ipóthová
    Department of Chemical and Biochemical Engineering, Faculty of Chemical and Food Technology, Slovak Technical University, Radlinskeho 9, 812 37 Bratislava, Slovak Republic Electronic address
    Bioorg Med Chem 21:6726-31. 2013
    ..Cytotoxicity of hexyl-AcrDIM is closely connected with induction of oxidative stress in cells. ..
  59. pmc Needle-based fluorescence endomicroscopy via structured illumination with a plastic, achromatic objective
    Matthew Kyrish
    Rice University, Department of Bioengineering, 6100 Main Street, Houston, Texas 77005
    J Biomed Opt 18:096003. 2013
    ..The objective is corrected for the excitation and the emission wavelengths of proflavine (452 and 515 nm)...
  60. ncbi Energy component analysis of π interactions
    C David Sherrill
    Center for Computational Molecular Science and Technology, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States
    Acc Chem Res 46:1020-8. 2013
    ..We discuss a recent study of the intercalation complex of proflavine with a trinucleotide duplex of DNA...
  61. ncbi Photoabsorption of acridine yellow and proflavin bound to human serum albumin studied by means of quantum mechanics/molecular dynamics
    Kestutis Aidas
    Department of General Physics and Spectroscopy, Faculty of Physics, Vilnius University, Saulėtekio al 9, LT 10222 Vilnius, Lithuania
    J Phys Chem B 117:2069-80. 2013
    ..The ramifications of this finding for design of molecular probes targeting albumin or other proteins is briefly discussed...
  62. pmc Discrimination of benign and neoplastic mucosa with a high-resolution microendoscope (HRME) in head and neck cancer
    Peter M Vila
    Department of Otolaryngology Head and Neck Surgery, Mount Sinai School of Medicine, New York, NY, USA
    Ann Surg Oncol 19:3534-9. 2012
    ..Our goal was to determine the accuracy and inter-rater reliability of head and neck cancer specialists using high-resolution microendoscopic (HRME) images to discriminate between cancerous and benign mucosa...
  63. ncbi Acridine: a versatile heterocyclic nucleus
    Ramesh Kumar
    Lord Shiva College of Pharmacy, Sirsa 125055, Haryana, India
    Acta Pol Pharm 69:3-9. 2012
    ..A number of therapeutic agents are based on acridine nucleus such as quinacrine (antimalarial), acriflavine and proflavine (antiseptics), ethacridine (abortifacient), amsacrine and nitracine (anticancer), and tacrine...
  64. ncbi Intermolecular hydrogen bonds in hetero-complexes of biologically active aromatic molecules probed by the methods of vibrational spectroscopy
    M A Semenov
    A Ya Usikov Institute of Radiophysics and Electronics, National Academy of Sciences of the Ukraine, 12 Acad Proscura Str, Kharkiv 61085, Ukraine
    Spectrochim Acta A Mol Biomol Spectrosc 95:224-9. 2012
    ..of biologically active aromatic compounds: flavin-mononucleotide (FMN), ethidium bromide (EB) and proflavine (PRF) was performed in aqueous solutions...
  65. ncbi Local clinical phototreatment of herpes infection in São Paulo
    João Paulo Tardivo
    Fundação Medicina ABC, Santo Andre, SP, Brazil
    Photodiagnosis Photodyn Ther 9:118-21. 2012
    ..use of the non-toxic photosensitisers methylene blue and Hypericum perforatum extract in place of proflavine and neutral red in the original trials, differences in photosensitisation pathway and illumination of the ..
  66. ncbi Stabilization of the T-state of human hemoglobin by proflavine, an antiseptic drug
    P Ascenzi
    Department of Biology, University of Rome Tre, Italy
    Biochem Mol Biol Int 47:991-5. 1999
    The effect of proflavine (3,6-diaminoacridine), an antiseptic drug, on the spectroscopic and oxygen binding properties of ferrous human adult hemoglobin (Hb) has been investigated...
  67. ncbi Patterns of strongly protein-associated simian virus 40 DNA replication intermediates resulting from exposures to specific topoisomerase poisons
    C G Shin
    Department of Radiology, Ohio State University, Columbus 43210 1214
    Biochemistry 29:10934-9. 1990
    ..The protein associated with form I DNA may represent a drug-stabilized "topological complex" between type II topoisomerase and SV40 DNA...
  68. ncbi Fluorimetric study on the interaction between Norfloxacin and Proflavine hemisulphate
    Vishalkumar R More
    Department of Chemistry, Fluorescence Spectroscopy Research Laboratory, Shivaji University, Kolhapur 416 004 Maharashtra, India
    J Fluoresc 21:1789-96. 2011
    The interaction between Norfloxacin (NF) and Proflavine hemisulphate (PF) was investigated by spectroscopic tools like UV-VIS absorption and Fluorescence spectroscopy...
  69. ncbi Proflavine derivatives as fluorescent imaging agents of amyloid deposits
    Dominique Garin
    INSERM, Unit U877, J Fourier University, La Tronche, France
    Bioorg Med Chem Lett 21:2203-6. 2011
    A series of proflavine derivatives for use to further image Aβ amyloid deposits were synthesized and characterized...
  70. ncbi Amplified detection of DNA hybridization using post-labelling with a biotin-modified intercalator
    Magdalena Gebala
    Analytische Chemie Elektroanalytik and Sensorik, Ruhr Universitat Bochum, Universiätsstr 150, D 44780 Bochum, Germany
    Faraday Discuss 149:11-22; discussion 63-77. 2011
    ..assay strategy the obtained double-stranded DNA (dsDNA) is at first non-covalently labeled by intercalation of a proflavine derivative which is functionalized via a flexible spacer with biotin moieties...
  71. ncbi c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators
    Shizuka Nakayama
    Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA
    Chem Commun (Camb) 47:4766-8. 2011
    ..G-quadruplexes at physiological conditions in the presence of some aromatic compounds, such as acriflavine and proflavine. The fluorescence of these compounds is quenched upon c-di-GMP binding and some of the formed c-di-GMP G-..
  72. ncbi Binding of alkaloids into the S1 specificity pocket of α-chymotrypsin: evidence from induced circular dichroism spectra
    Ferenc Zsila
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, H 1025, Budapest, Pusztaszeri u 59 67, Hungary
    Org Biomol Chem 9:4127-37. 2011
    ..Utilizing this phenomenon, αCHT association of proflavine (PRF), the well known serine protease inhibitor has been investigated together with plant-derived compounds ..
  73. ncbi Molecular modeling study of intercalation complexes of tricyclic carboxamides with d(CCGGCGCCGG)₂ and d(CGCGAATTCGCG)₂
    Athanasia Varvaresou
    Laboratory of Cosmetology, Department of Aesthetics and Cosmetology, Technological Educational Institution of Athens, Ag Spyridona, Egaleo, 12 210 Athens, Greece
    J Mol Model 17:2041-50. 2011
    Tricyclic dyes with different mesoatoms such as xanthenes (fluorescein, eosin) anthracenes and acridines (proflavine) approved by the Food and Drug Administration (FDA) for use in foods, pharmaceuticals and cosmetic preparations interact ..
  74. pmc Fluorescent labeling of tRNA dihydrouridine residues: Mechanism and distribution
    Jaskiran Kaur
    Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6323, USA
    RNA 17:1393-400. 2011
    ....
  75. ncbi Contact dermatitis complicating pinnaplasty
    G Singh-Ranger
    St Andrew's Centre for Plastic Surgery and Burns, Broomfield Hospital, Court Road, Broomfield, Essex CM1 7RT, UK
    Br J Plast Surg 54:243-5. 2001
    b>Proflavine allergy is uncommon, occurring in approximately 6% of patients attending contact dermatitis clinics...
  76. pmc Expression of Escherichia coli TehA gives resistance to antiseptics and disinfectants similar to that conferred by multidrug resistance efflux pumps
    R J Turner
    Department of Biochemistry, University of Alberta, Edmonton, Canada
    Antimicrob Agents Chemother 41:440-4. 1997
    ..TehA was also found to have proflavin efflux activity. The addition of TeO32- to the proflavin transport assay on TehA caused a 20% increase in transport rate. Both ethidium and proflavin transport were found to be energy dependent...
  77. ncbi In-vitro photobactericidal activity of aminoacridines
    M Wainwright
    Department of Chemistry, University of Central Lancashire, Preston, UK
    J Antimicrob Chemother 40:587-9. 1997
    ..Derivatives of 9-aminoacridine (aminacrine) exhibited phototoxicity against one or more of the test organisms, but the established photosensitizing acridines proflavine and acridine orange were photobactericidal against all strains.
  78. ncbi Enantiospecific recognition of DNA sequences by a proflavine Tröger base
    C Bailly
    INSERM U 524 et Laboratoire de Pharmacologie du Centre Oscar Lambret, Institut de Recherches sur le Cancer, Place de Verdun, Lille, 59045, France
    Biochem Biophys Res Commun 273:681-5. 2000
    The DNA interaction of a chiral Tröger base derived from proflavine was investigated by DNA melting temperature measurements and complementary biochemical assays...
  79. ncbi Inhibition of RNA synthesis in vitro by acridines--relation between structure and activity
    M K Piestrzeniewicz
    Department of General Chemistry, , Poland
    Z Naturforsch C 53:359-68. 1998
    The effects of acridine derivatives (proflavine and 2,7-dialkyl derivatives, diacridines and triacridines, 9-aminoacridine carboxamides, and 9-anilinoacridine, amsacrine and its congeners) on overall RNA synthesis in vitro, on synthesis ..
  80. ncbi NMR investigation of the complexation of daunomycin with deoxytetranucleotides of different base sequence in aqueous solution
    D B Davies
    School of Biological and Chemical Sciences, Birkbeck College, University of London, UK
    J Biomol Struct Dyn 17:887-901. 2000
    ..with either single or double-stranded tetranucleotides, in contrast with other intercalating drugs such as proflavine, ethidium bromide and actinomycin D...
  81. pmc Low dielectric response in enzyme active site
    E L Mertz
    Laboratory of Physical and Structural Biology, National Institute of Child Health and Human Development, National Institutes of Health, Building 9, Room 1E-122, 9000 Rockville Pike, Bethesda, MD 20892-0924, USA
    Proc Natl Acad Sci U S A 97:2081-6. 2000
    ..This reduction is particularly important for controlling the rate of enzymatic reactions...
  82. ncbi Multiphoton near-infrared femtosecond laser pulse-induced DNA damage with and without the photosensitizer proflavine
    V Shafirovich
    Chemistry Department, New York University, NY 10003 5180, USA
    Photochem Photobiol 69:265-74. 1999
    ..luteus) were not observed under these conditions. However, in the presence of 6 microM of the intercalator proflavine (PF), both direct single- and double-strand breaks are observed under conditions where substantial fractions of ..
  83. ncbi The qacG gene on plasmid pST94 confers resistance to quaternary ammonium compounds in staphylococci isolated from the food industry
    E Heir
    MATFORSK, Norwegian Food Research Institute, As, Norway
    J Appl Microbiol 86:378-88. 1999
    ....
  84. ncbi Existence of a new emitting singlet state of proflavine: femtosecond dynamics of the excited state processes and quantum chemical studies in different solvents
    Karuppannan Senthil Kumar
    National Centre for Ultrafast Processes, Taramani Campus, University of Madras, Chennai 600 113, India
    J Phys Chem A 116:37-45. 2012
    b>Proflavine (3,6-diaminoacridine) shows fluorescence emission with lifetime, 4.6 ± 0.2 ns, in all the solvents irrespective of the solvent polarity...
  85. ncbi Fluorophore labeling to monitor tRNA dynamics
    Cuiping Liu
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Methods Enzymol 469:69-93. 2009
    ....
  86. pmc Synthesis, characterization and cytotoxicity studies of palladium(II)-proflavine complexes
    Tatyana V Polyanskaya
    Department of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, United States
    J Inorg Biochem 104:1205-13. 2010
    An investigation of the reaction of Pd(II) complexes with proflavine (3,6-diaminoacridine) resulted in the isolation of the compounds [Pd(terpy)(proflavine)](NO(3))(HSO(4))*3H(2)O, 1, (terpy = 2,2':6',2″-terpyridine), [Pd(en)(..
  87. ncbi Proflavine acts as a Rev inhibitor by targeting the high-affinity Rev binding site of the Rev responsive element of HIV-1
    Eric S DeJong
    Center for Advanced Research in Biotechnology of the University of Maryland Biotechnology Institute and the National Institute for Standards and Technology, 9600 Gudelsky Drive, Rockville, Maryland 20850, USA
    Biochemistry 42:8035-46. 2003
    ..Using these fluorescence and nuclear magnetic resonance (NMR) methods, proflavine has been identified, through a limited screen of selected small heterocyclic compounds, as a specific and high-..
  88. ncbi Catalytic properties of monoamine oxidase from mink (Mustela vison) liver
    O V Yagodina
    Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr Morisa Toreza 44, St Petersburg, 194223, Russia
    Dokl Biochem Biophys 415:200-2. 2007
  89. pmc Ligand-transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay
    Chih Chia Su
    Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, United States
    FEBS Lett 581:4972-6. 2007
    ..Our assays indicate that the transporter binds these drugs with K(D) values ranging from 5.5 to 74.1microM...
  90. ncbi Quantifying RNA-peptide interaction by single-quantum dot-based nanosensor: an approach for drug screening
    Chun Yang Zhang
    Department of Chemistry, York College and The Graduate Center, The City University of New York, Jamaica, New York 11451, USA
    Anal Chem 79:7775-81. 2007
    ..The application of this nanosensor in the screening of libraries of small-molecule drugs will facilitate the development of new drugs against various diseases, cancers, and HIV...
  91. ncbi Equilibria and kinetics of the intercalation of Pt-proflavine and proflavine into calf thymus DNA
    Tarita Biver
    Dipartimento di Chimica e Chimica Industriale, Universita di Pisa, Via Risorgimento 35, 56126 Pisa, Italy
    Arch Biochem Biophys 418:63-70. 2003
    The interaction of the cis-platinum derivative of proflavine [[PtCl(tmen)(2)][HNC(13)H(7)(NHCH(2)CH(2))(2)]](+) (PRPt) with CT-DNA is investigated by spectrophotometry and T-jump relaxation in 0.11M NaCl, pH 7.0, and 25 degrees C...
  92. pmc Fluorescent labeling of tRNAs for dynamics experiments
    Thu Betteridge
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    RNA 13:1594-601. 2007
    ..Such labeled tRNAs should have broad utility in research that involves studies of tRNA maturation, aminoacylation, and tRNA-ribosome interactions...
  93. pmc Characterization of the multidrug efflux regulator AcrR from Escherichia coli
    Chih Chia Su
    Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA
    Biochem Biophys Res Commun 361:85-90. 2007
    ..In contrast, the dissociation constant of proflavin binding to AcrR was not affected by ethidium, a result suggesting that ethidium and proflavin are bound to distinct binding sites...
  94. ncbi Enzymatic behavior by intercalating molecules in a template-directed ligation reaction
    Swapan S Jain
    School of Chemistry and Biochemistry, Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Angew Chem Int Ed Engl 43:2004-8. 2004
  95. ncbi Protonation linked equilibria and apparent affinity constants: the thermodynamic profile of the alpha-chymotrypsin-proflavin interaction
    Gilles Bruylants
    Ingénierie Moléculaire et Biomoléculaire, CP 165 64, Universite Libre de Bruxelles, 50 Av F D Roosevelt, 1050 Bruxelles, Belgium
    Eur Biophys J 37:11-8. 2007
    ..This study emphasises the complementarities between ITC and NMR for the study of binding processes involving protonation/deprotonation equilibria...
  96. ncbi Effects of guanosine on the pharmacokinetics of acriflavine in rats following the administration of a 1:1 mixture of acriflavine and guanosine, a potential antitumor agent
    Pung Sok Lee
    National Research Laboratory NRL of PK PD, CBITRC, Biotechnology Research Institute, College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 361 763, Korea
    Arch Pharm Res 30:372-80. 2007
    ..method, which was validated in this laboratory, was used to analyze the levels of trypaflavine (TRF) and proflavine (PRF) in the plasma, bile, urine, and tissue homogenates...
  97. ncbi Changes in newborn bathing practices may increase the risk for omphalitis
    Neal P Simon
    Department of Pediatrics, Indiana University, Indianapolis, IN 46202, USA
    Clin Pediatr (Phila) 43:763-7. 2004
    ..Three cases of omphalitis occurring after an institutional change to nonantiseptic whole-body baths are presented. Clinical diagnosis and treatment of omphalitis are reviewed. Recommendations for surveillance of omphalitis are offered...
  98. ncbi Dye-induced aggregation of single stranded RNA: a mechanistic approach
    Tarita Biver
    Dipartimento di Chimica e Chimica Industriale, Universita di Pisa, Via Risorgimento, 35 56126 Pisa, Italy
    Arch Biochem Biophys 452:93-101. 2006
    The binding of proflavine (D) to single stranded poly(A) (P) was investigated at pH 7.0 and 25 degrees C using T-jump, stopped-flow and spectrophotometric methods...
  99. ncbi Determination of the DNA-binding characteristics of ethidium bromide, proflavine, and cisplatin by flow injection analysis: usefulness in studies on antitumor drugs
    A Alonso
    Departamento de Quimica Analitica, Nutricion y Bromatologia, Faculty of Chemistry, University of Salamanca, E 37008 Salamanca, Spain
    Anal Biochem 355:157-64. 2006
    ..327+/-0.009) were determined. The modification introduced in these parameters by the presence of proflavine (Prf), a classic competitive inhibitor of the binding of EtdBr to the DNA double helix, was also studied, ..
  100. ncbi Characterization of a two-gene operon epeRA involved in multidrug resistance in Streptomyces clavuligerus
    Antonio Rodríguez-García
    Area de Microbiologia, Facultad de Ciencias Biologicas y Ambientales, Universidad de Leon, 24071 Leon, Spain
    Res Microbiol 157:559-68. 2006
    ..clavuligerus epeR::aph mutant which shows increased resistance to ethidium bromide and proflavine (16- and 32-fold higher than the wild type)...
  101. ncbi Dendrimers with both polar and apolar nanocontainer characteristics
    Dharma Rao Vutukuri
    Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Am Chem Soc 126:15636-7. 2004
    ..These container properties were investigated using dye incorporation studies. The aggregation states of these dendrimers are also reported using DLS studies...

Research Grants2

  1. A STUDY OF DNA INTERCALATING AROMATIC AMINO AZIDES
    Matthew Platz; Fiscal Year: 1991
    ..and EPR spectroscopy to identify the specific intermediate(s) produced by photolysis of ethidium azide and proflavine azide. We will photolyze these azides intercalated into mini duplexes of self complementary dinucleotides...
  2. 13C AND OTHER NUCLEI NMR OF DNA AND DNA INTERACTIONS
    GEORGE LEVY; Fiscal Year: 1980
    ..Small molecules chosen for study include intercalating agents (proflavine, ethidium, quinacrine, actinomycin D; a steroid diamine (dipyrandium): alkylating agents potentially useful as ..