- Ciprofloxacin causes persister formation by inducing the TisB toxin in Escherichia coli
Department of Biology, Northeastern University, Antimicrobial Discovery Center, Boston, Massachusetts, United States of America
PLoS Biol 8:e1000317. 2010
..a knockout of a particular SOS-TA locus, tisAB/istR, had a sharply decreased level of persisters tolerant to ciprofloxacin, an antibiotic that causes DNA damage...
- Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme
Chi Hye Park
Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 2696, USA
Antimicrob Agents Chemother 50:3953-5. 2006
Among 313 Enterobacteriaceae from the United States with a ciprofloxacin MIC of >/=0.25 microg/ml and reduced susceptibility to ceftazidime, aac(6')-Ib was present in 50...
- Contributions of antibiotic penetration, oxygen limitation, and low metabolic activity to tolerance of Pseudomonas aeruginosa biofilms to ciprofloxacin and tobramycin
Marshall C Walters
Center for Biofilm Engineering, Department of Chemical Engineering, Montana State University Bozeman, Bozeman, Montana 59717 3980, USA
Antimicrob Agents Chemother 47:317-23. 2003
..Tobramycin and ciprofloxacin penetrated biofilms but failed to effectively kill the bacteria...
- Type IIA topoisomerase inhibition by a new class of antibacterial agents
Benjamin D Bax
Molecular Discovery Research, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
Nature 466:935-40. 2010
..This work provides new insights into the mechanism of topoisomerase action and a platform for structure-based drug design of a new class of antibacterial agents against a clinically proven, but conformationally flexible, enzyme class...
- Structural changes induced by a lytic bacteriophage make ciprofloxacin effective against older biofilm of Klebsiella pneumoniae
Department of Microbiology, Basic Medical Sciences BMS Block, Panjab University, Chandigarh, India
Biofouling 26:729-37. 2010
..It has been documented that young biofilm of Klebsiella pneumoniae could be eradicated significantly by ciprofloxacin treatment alone...
- Mechanisms of resistance to quinolones
George A Jacoby
Lahey Clinic, Burlington, Massachusetts 01805, USA
Clin Infect Dis 41:S120-6. 2005
..Although Qnr by itself produces only low-level resistance, its presence facilitates the selection of higher-level resistance mutations, thus contributing to the alarming increase in resistance to quinolones...
- Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase
Harvard Medical School, Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit St, GRJ 512, Boston, Massachusetts 02114, USA
Nat Med 12:83-8. 2006
..We describe reduced susceptibility to ciprofloxacin in clinical bacterial isolates conferred by a variant of the gene encoding aminoglycoside acetyltransferase ..
- Enteric fever in Cambodian children is dominated by multidrug-resistant H58 Salmonella enterica serovar Typhi with intermediate susceptibility to ciprofloxacin
Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
Trans R Soc Trop Med Hyg 106:718-24. 2012
..resistant (MDR: resistant to chloramphenicol, ampicillin, trimethoprim-sulphamethoxazole) with intermediate ciprofloxacin susceptibility are widespread in Asia but there is little information from Cambodia...
- Complete and SOS-mediated response of Staphylococcus aureus to the antibiotic ciprofloxacin
Ryan T Cirz
Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
J Bacteriol 189:531-9. 2007
..antibiotic therapy and eventually emerges resistant, we characterized its global transcriptional response to ciprofloxacin. We found that ciprofloxacin induces prophage mobilization as well as significant alterations in metabolism, ..
- Role of nutrient limitation and stationary-phase existence in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin
Jeff N Anderl
Center for Biofilm Engineering, Montana State University, Bozeman, Montana 59717 3980, USA
Antimicrob Agents Chemother 47:1251-6. 2003
Biofilms formed by Klebsiella pneumoniae resisted killing during prolonged exposure to ampicillin or ciprofloxacin even though these agents have been shown to penetrate bacterial aggregates...
- Role of rifampin for treatment of orthopedic implant-related staphylococcal infections: a randomized controlled trial. Foreign-Body Infection (FBI) Study Group
Department of Internal Medicine, University Hospitals, Basel, Switzerland
JAMA 279:1537-41. 1998
..Rifampin-containing regimens are able to cure staphylococcal implant-related infections based on in vitro and in vivo observations. However, this evidence has not been proven by a controlled clinical trial...
- Pseudomonas aeruginosa increases formation of multidrug-tolerant persister cells in response to quorum-sensing signaling molecules
Department of Infectious Diseases, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA
J Bacteriol 192:1946-55. 2010
..aeruginosa PAO1 or PA14 cultures but not in E. coli or S. aureus cultures...
- Inhibition of mutation and combating the evolution of antibiotic resistance
Ryan T Cirz
Department of Chemistry, The Scripps Research Institute, La Jolla, California, USA
PLoS Biol 3:e176. 2005
..the activity of the protease LexA renders pathogenic Escherichia coli unable to evolve resistance in vivo to ciprofloxacin or rifampicin, important quinolone and rifamycin antibiotics...
- Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation
Anskar Y H Leung
Department of Medicine, University of Hong Kong, China
Clin Infect Dis 40:528-37. 2005
..The objective of this study was to test whether standard-dose ciprofloxacin might suppress reactivation of BKV infection during HSCT.
- Ciprofloxacin dosage and emergence of resistance in human commensal bacteria
Universite Paris Diderot, Paris, France
J Infect Dis 200:390-8. 2009
..Although optimization of the fluoroquinolone dosage increases the efficacy of this class of drugs against bacterial infections, its impact on the emergence of resistance in commensal bacteria is unknown...
- Fitness costs and stability of a high-level ciprofloxacin resistance phenotype in Salmonella enterica serotype enteritidis: reduced infectivity associated with decreased expression of Salmonella pathogenicity island 1 genes
Centre for Food Safety, UCD Veterinary Sciences Centre, University College Dublin, Belfield, Dublin 4, Ireland
Antimicrob Agents Chemother 54:367-74. 2010
..with high-level fluoroquinolone resistance were examined for phenotypically and genotypically characterized ciprofloxacin-resistant Salmonella enterica serotype Enteritidis mutants (104-cip and 5408-cip; MIC, >32 microg/ml)...
- Berberis aetnensis C. Presl. extracts: antimicrobial properties and interaction with ciprofloxacin
Department of Microbiological and Gynaecological Sciences, Section of Microbiology, University of Catania, Via Androne 81, 95124 Catania, Italy
Int J Antimicrob Agents 22:48-53. 2003
..In fact, the activity of ciprofloxacin was improved when two chromatographic fractions isolated from leaf extracts were added...
- Azithromycin and ciprofloxacin resistance in Salmonella bloodstream infections in Cambodian adults
Erika R Vlieghe
Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Antwerp, Belgium
PLoS Negl Trop Dis 6:e1933. 2012
..We describe Salmonella BSI isolates recovered from patients presenting at Sihanouk Hospital Centre of Hope, Phnom Penh, Cambodia (July 2007-December 2010)...
- Curcumin reduces the antimicrobial activity of ciprofloxacin against Salmonella typhimurium and Salmonella typhi
Sandhya A Marathe
Department of Microbiology and Cell Biology, Centre for Infectious Disease Research and Biosafety Laboratories, Indian Institute of Science, Bangalore 560012, India
J Antimicrob Chemother 68:139-52. 2013
Typhoidal and non-typhoidal infection by Salmonella is a serious threat to human health. Ciprofloxacin is the last drug of choice to clear the infection...
- Comparison of the prevalence and changing resistance to nalidixic acid and ciprofloxacin of Shigella between Europe-America and Asia-Africa from 1998 to 2009
Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road No 300, Nanjing 210029, China
Int J Antimicrob Agents 40:9-17. 2012
..0. In the area of Asia-Africa, resistance rates to nalidixic acid and ciprofloxacin were 33.6% [95% confidence interval (CI) 21.8-46.6%] and 5.0% (95% CI 2.8-7.8%), respectively, 10.5 and 16...
- The effect of freeze-drying with different cryoprotectants and gamma-irradiation sterilization on the characteristics of ciprofloxacin HCl-loaded poly(D,L-lactide-glycolide) nanoparticles
Laboratory of Pharmaceutical Technology and Biopharmacy, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
J Pharm Pharmacol 57:699-707. 2005
..cryoprotective agents and gamma (gamma)-irradiation sterilization on the physicochemical characteristics of ciprofloxacin HCl-loaded poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles was evaluated...
- Mechanism of plasmid-mediated quinolone resistance
John H Tran
Infectious Disease Department, Lahey Clinic, Burlington, MA 01805, USA
Proc Natl Acad Sci U S A 99:5638-42. 2002
..Purified Qnr-His(6) protected Escherichia coli DNA gyrase from inhibition by ciprofloxacin. Gyrase protection was proportional to the concentration of Qnr-His(6) and inversely proportional to the ..
- Ciprofloxacin resistance in Campylobacter jejuni evolves rapidly in chickens treated with fluoroquinolones
Patrick F McDermott
Division of Animal and Food Microbiology, Center for Veterinary Medicine, US Food and Drug Administration, Laurel, Maryland 20708, USA
J Infect Dis 185:837-40. 2002
..of sarafloxacin and enrofloxacin treatment of Campylobacter jejuni-infected chickens on the development of ciprofloxacin resistance were measured. Fecal samples were collected before and after treatment and were cultured for C...
- Swarming of Pseudomonas aeruginosa is a complex adaptation leading to increased production of virulence factors and antibiotic resistance
Centre for Microbial Diseases and Immunity Research, University of British Columbia, 2259 Lower Mall, Vancouver, BC, Canada
J Bacteriol 190:2671-9. 2008
..In addition, swarming cells exhibited adaptive antibiotic resistance against polymyxin B, gentamicin, and ciprofloxacin compared to what was seen for their planktonic (swimming) counterparts...
- SOS response promotes horizontal dissemination of antibiotic resistance genes
John W Beaber
Department of Microbiology, Tufts University School of Medicine and Howard Hughes Medical Institute, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
Nature 427:72-4. 2004
..SOS is induced by a variety of environmental factors and antibiotics, for example ciprofloxacin, and we show that ciprofloxacin induces SXT transfer as well...
- Immunomodulatory effects of quinolones
Institute for Medical Microbiology and Virology, Universitatsklinikum Schleswig Holstein, Campus Kiel, Germany
Lancet Infect Dis 3:359-71. 2003
- Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates
Sonia K Morgan-Linnell
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030 3411, USA
Antimicrob Agents Chemother 53:235-41. 2009
..In the accompanying report, we found that ciprofloxacin, gatifloxacin, levofloxacin, and norfloxacin MICs for fluoroquinolone-resistant E...
- Symptomatic treatment (ibuprofen) or antibiotics (ciprofloxacin) for uncomplicated urinary tract infection?--results of a randomized controlled pilot trial
Institute of General Practice Family Medicine, Hanover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
BMC Med 8:30. 2010
..This pilot study was set out 1) to make a rough estimate of the equivalence of ibuprofen and ciprofloxacin for uncomplicated urinary tract infection with regard to symptom resolution, and 2) to demonstrate the ..
- Two distinct mutations in gyrA lead to ciprofloxacin and nalidixic acid resistance in Campylobacter coli and Campylobacter jejuni isolated from chickens and beef cattle
T W Jesse
Bacterial Epidemiology and Antimicrobial Resistance Research Unit, U S Department of Agriculture, Agricultural Research Service, Athens, GA 30605 2720, USA
J Appl Microbiol 100:682-8. 2006
..point mutations in the gyrA quinolone resistance determining region (QRDR) of Campylobacter coli (n = 27) and Campylobacter jejuni (n = 26) that confer nalidixic acid (NAL) resistance without conferring resistance to ciprofloxacin (CIP).
- Prevalence of mutations within the quinolone resistance-determining region of gyrA, gyrB, parC, and parE and association with antibiotic resistance in quinolone-resistant Salmonella enterica
Deborah J Eaves
Antimicrobial Agents Research Group, Division of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
Antimicrob Agents Chemother 48:4012-5. 2004
..Although it is counterintuitive, isolates with a mutation in both gyrA and parC were more susceptible to ciprofloxacin than were isolates with a mutation in gyrA alone.
- Probing the interaction of human serum albumin with ciprofloxacin in the presence of silver nanoparticles of three sizes: multispectroscopic and ζ potential investigation
Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran
J Phys Chem B 116:1951-64. 2012
The binding of ciprofloxacin to human serum albumin (HSA) in the presence and absence of silver nanoparticles of three sizes was investigated for the first time...
- Effect of topical dexamethasone and ciprofloxacin on bacterial flora of healthy conjunctiva
S S Ermis
Department of Ophthalmology, School of Medicine, University of Afyon, Kocatepe, Afyon, Turkey
Eye (Lond) 18:249-52. 2004
To investigate the effects of topical dexamethasone and ciprofloxacin, alone and in combination, on the colony counts of conjunctival bacterial flora of healthy subjects.
- Effects of ciprofloxacin on the expression and production of exotoxins by Clostridium difficile
Michael John Aldape
Department of Veterans Affairs Medical Center, Boise, ID, USA
J Med Microbiol 62:741-7. 2013
..However, the mechanism for this is not clear. We compared the effects of subinhibitory concentrations of ciprofloxacin on Toxin A and B gene expression and protein production in recent (strain 039) and historical (strain 5325) BI/..
- Phenotypic changes in ciprofloxacin-resistant Staphylococcus aureus
Lili R Mesak
Department of Microbiology and Immunology, University of British Columbia, Life Sciences Institute, 2350 Health Science Mall, Vancouver, BC V6T1Z3, Canada
Res Microbiol 160:785-91. 2009
..fluoroquinolone moxifloxacin induced expression of SOS response genes (lexA, recA, sosA, and umuC) in a ciprofloxacin-resistant Cip(r)I strain of S. aureus...
- Effects of subinhibitory concentrations of amikacin and ciprofloxacin on the hydrophobicity and adherence to epithelial cells of uropathogenic Escherichia coli strains
Department of Biology and Medical Parasitology, Medical University of Wroclaw, Mikulicza Radeckiego 9, 50 367 Wroclaw, Poland
Int J Antimicrob Agents 29:700-4. 2007
The effect of subinhibitory concentrations of amikacin and ciprofloxacin on the hydrophobicity and adherence to uroepithelial cells of Escherichia coli strains was investigated...
- Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections
Patricia Komp Lindgren
Department of Cell and Molecular Biology, Microbiology Programme, Biomedical Center, Uppsala University, S 751 24 Uppsala, Sweden
Antimicrob Agents Chemother 47:3222-32. 2003
..This correlation suggests that an increased general mutation rate may play a significant role in the development of high-level resistance to fluoroquinolones by increasing the rate of accumulation of rare new mutations...
- Ciprofloxacin-resistant Salmonella Kentucky in travelers
Francois Xavier Weill
Emerg Infect Dis 12:1611-2. 2006
- In vitro activity of fosfomycin against ciprofloxacin-resistant or extended-spectrum beta-lactamase-producing Escherichia coli isolated from urine and blood
Kwan Soo Ko
Asian Pacific Research Foundation for Infectious Diseases, Seoul 135 710, Korea
Diagn Microbiol Infect Dis 58:111-5. 2007
..in vitro activity of fosfomycin and 7 other comparator agents against 307 Escherichia coli isolates including ciprofloxacin-resistant or extended-spectrum beta-lactamase (ESBL)-producing isolates...
- Antimicrobial resistance trends in blood culture positive Salmonella Typhi isolates from Pondicherry, India, 2005-2009
G A Menezes
Department of Microbiology, Institute of National Importance, Jawaharlal Institute of Postgraduate Medical Education and Research JIPMER, Pondicherry, India
Clin Microbiol Infect 18:239-45. 2012
..Recently, there has been an upsurge in the occurrence of bacterial isolates that are resistant to ciprofloxacin, and the emergence of broad spectrum β-lactamases in typhoidal salmonellae constitutes a new challenge for ..
- Platelet-rich plasma protects tenocytes from adverse side effects of dexamethasone and ciprofloxacin
Nasim Zargar Baboldashti
Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK
Am J Sports Med 39:1929-35. 2011
..The authors assessed the ability of PRP to prevent in vitro adverse effects of 2 drugs commonly linked to tendon rupture and tendinopathy, glucocorticoids and fluoroquinolone antibiotics...
- Involvement of the lon protease in the SOS response triggered by ciprofloxacin in Pseudomonas aeruginosa PAO1
Elena B M Breidenstein
Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, Canada
Antimicrob Agents Chemother 56:2879-87. 2012
..of deficiencies in cell division, swarming, twitching, and biofilm formation as well as a phenotype of ciprofloxacin supersusceptibility...
- Trimethoprim and ciprofloxacin resistance and prescribing in urinary tract infection associated with Escherichia coli: a multilevel model
Discipline of Bacteriology, NUI Galway, Galway, Ireland
J Antimicrob Chemother 67:2523-30. 2012
..Individual and group level factors associated with the probability of antimicrobial resistance of uropathogenic Escherichia coli were analysed in a multilevel model...
- Ciprofloxacin resistance in Campylobacter jejuni isolates: detection of gyrA resistance mutations by mismatch amplification mutation assay PCR and DNA sequence analysis
National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Atlanta, Georgia 30333, USA
J Clin Microbiol 37:3276-80. 1999
The gyrA quinolone resistance determining region was sequenced from 13 ciprofloxacin-resistant and 20 ciprofloxacin-susceptible Campylobacter jejuni isolates...
- Factors related to increasing prevalence of resistance to ciprofloxacin and other antimicrobial drugs in Neisseria gonorrhoeae, United States
Harvard School of Public Health, Boston, Massachusetts 02115, USA
Emerg Infect Dis 18:1290-7. 2012
Using data from the Gonococcal Isolate Surveillance Project, we studied changes in ciprofloxacin resistance in Neisseria gonorrhoeae isolates in the United States during 2002-2007...
- Diversity of individual dynamic patterns of emergence of resistance to quinolones in Escherichia coli from the fecal flora of healthy volunteers exposed to ciprofloxacin
Victoire de Lastours
Univ Paris Diderot, EA 3964 Laboratory, Sorbonne Paris Cité, France
J Infect Dis 206:1399-406. 2012
Emergence of quinolone-resistant Escherichia coli (QREC) is an increasing clinical challenge mostly originating in fecal microbiota. The dynamics of the emergence of QREC in feces from individuals exposed to ciprofloxacin is unknown.
- Synergistic effects of baicalein with ciprofloxacin against NorA over-expressed methicillin-resistant Staphylococcus aureus (MRSA) and inhibition of MRSA pyruvate kinase
Ben C L Chan
Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
J Ethnopharmacol 137:767-73. 2011
..The aim of the present study was to further investigate antibacterial activities of baicalein in association with various antibiotics against selected Staphylococcus aureus strains with known specific drug resistance mechanisms...
- Incidence and mechanism of ciprofloxacin resistance in Campylobacter spp. isolated from commercial poultry flocks in the United Kingdom before, during, and after fluoroquinolone treatment
Deborah J Griggs
Antimicrobial Agents Research Group, Division of Immunity and Infection, The Medical School, University of Birmingham, Birmingham B15 2TT, United Kingdom
Antimicrob Agents Chemother 49:699-707. 2005
..Multidrug resistance was significantly (P < 0.01) associated with resistance to ciprofloxacin. Twenty-five percent (73 of 290) of ciprofloxacin-resistant isolates but only 13% (24 of 179) of susceptible ..
- Campylobacter susceptibility to ciprofloxacin and corresponding fluoroquinolone concentrations within the gastrointestinal tracts of chickens
M B Farnell
Poultry Production and Product Safety Research Unit, Agricultural Research Service, USDA, Fayetteville, AR 72701, USA
J Appl Microbiol 99:1043-50. 2005
..This study evaluated the relationship between Campylobacter susceptibility and enteric fluoroquinolone concentrations in chickens treated with different doses of enrofloxacin...
- Ciprofloxacin safety in paediatrics: a systematic review
Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Derby DE22 3DT, UK
Arch Dis Child 96:874-80. 2011
To determine the safety of ciprofloxacin in paediatric patients in relation to arthropathy, any other adverse events (AEs) and drug interactions.
- Characterization of Abcc4 gene amplification in stepwise-selected mouse J774 macrophages resistant to the topoisomerase II inhibitor ciprofloxacin
Universite Catholique de Louvain, Louvain Drug Research Institute, Pharmacologie Cellulaire et Moléculaire, Brussels, Belgium
PLoS ONE 6:e28368. 2011
Exposure of J774 mouse macrophages to stepwise increasing concentrations of ciprofloxacin, an antibiotic inhibiting bacterial topoisomerases, selects for resistant cells that overexpress the efflux transporter Abcc4 (Marquez et al...
- Suitable disk antimicrobial susceptibility breakpoints defining Salmonella enterica serovar Typhi isolates with reduced susceptibility to fluoroquinolones
Christopher M Parry
The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Vietnam
Antimicrob Agents Chemother 54:5201-8. 2010
..25 μg/ml) or ciprofloxacin (MIC ≥ 0...
- International spread of an epidemic population of Salmonella enterica serotype Kentucky ST198 resistant to ciprofloxacin
Simon Le Hello
Institut Pasteur, unité des bactéries pathogènes entériques, Centre national de référence des Salmonella, World Health Organization WHO Collaborating Centre for Reference and Research on Salmonella, Paris, France
J Infect Dis 204:675-84. 2011
..of multidrug-resistant isolates of Salmonella enterica serotype Kentucky displaying high-level resistance to ciprofloxacin. A total of 489 human cases were identified during the period from 2002 (3 cases) to 2008 (174 cases)...
- Restricting ciprofloxacin-induced resistant variant formation in biofilm of Klebsiella pneumoniae B5055 by complementary bacteriophage treatment
Department of Microbiology, Basic Medical Sciences BMS Block, Panjab University, Chandigarh, India
J Antimicrob Chemother 64:1212-8. 2009
..of lytic bacteriophage as a therapeutic agent against Klebsiella pneumoniae biofilm, alone or in combination with ciprofloxacin, was studied. The pathogenic potential of the resistant variants formed during the treatment was evaluated.
- A randomized trial comparing four Helicobacter pylori eradication regimens: standard triple therapy, ciprofloxacin based triple therapy, quadruple and sequential therapy
Gastrointestinal and Liver Diseases Research Center GLDRC, Razi Hospital, Tehran, Iran
Trop Gastroenterol 31:303-7. 2010
..Helicobacter pylori infection is found in at least 80% of people in developing countries. This randomized controlled trial was performed to evaluate the efficacy of 4 different H. pylori eradication regimens in Iranian patients...
- In vitro and in vivo reduced fitness and virulence in ciprofloxacin-resistant Acinetobacter baumannii
Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, University Hospital Virgen del Rocío CSIC University of Seville, Seville, Spain
Clin Microbiol Infect 18:E1-4. 2012
..We aimed to study the virulence and fitness cost of ciprofloxacin-resistance in A. baumannii (CipR) compared with the susceptible parental wild-type strain (CipS)...
- Emergence of ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates from healthy children and pediatric patients in Portugal
Centro de Recursos Microbiológicos, Departamento de Ciências da Vida, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, Campus de Caparica, Caparica, Portugal
Antimicrob Agents Chemother 54:2677-80. 2010
We describe 66 ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates recovered from colonized and infected children. The ParC S79A substitution was frequent and associated with the emm6/sequence type 382 (emm6/ST382) lineage...
- High-level ciprofloxacin resistance from point mutations in gyrA and parC confined to global hospital-adapted clonal lineage CC17 of Enterococcus faecium
Helen L Leavis
Department of Internal Medicine, Division of Infectious Diseases and Internal Medicine, Eijkman Winkler Institute, University Medical Center Utrecht, Heidelberglaan 100, Rm G04 614, 3584CX Utrecht, The Netherlands
J Clin Microbiol 44:1059-64. 2006
To substantiate a common genetic background of ciprofloxacin-resistant Enterococcus faecium, 32 ciprofloxacin-resistant (Cip(r)) and 31 ciprofloxacin-susceptible (Cip(s)) isolates from outbreaks, clinical infections, surveillances, and ..
- Preparation of in situ-forming ophthalmic gels of ciprofloxacin hydrochloride for the treatment of bacterial conjunctivitis: in vitro and in vivo studies
Naseem A Charoo
Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India
J Pharm Sci 92:407-13. 2003
Sol-to-gel systems of ciprofloxacin hydrochloride were prepared utilizing the phase transition properties of hydroxy propyl methyl cellulose K 15 M grade (HPMC) and carbopol 934...
- Ciprofloxacin use in neonates: a systematic review of the literature
Department of Pediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, APHP INSERM CIC9202 Université Paris 7, Paris, France
Pediatr Infect Dis J 30:e29-37. 2011
b>ciprofloxacin has no marketing authorization for use in neonates worldwide but it is prescribed for the treatment of neonatal life-threatening infections, mainly in developing countries and in Europe...
- Emergence of ciprofloxacin-resistant Neisseria meningitidis in North America
Henry M Wu
Office of Workforce and Career Development, and the Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
N Engl J Med 360:886-92. 2009
We report on three cases of meningococcal disease caused by ciprofloxacin-resistant Neisseria meningitidis, one in North Dakota and two in Minnesota. The cases were caused by the same serogroup B strain...
- Moxifloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis: evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacy
Radha K Shandil
AstraZeneca India Pvt Ltd, Hebbal, Bellary Road, Bangalore 560024, India
Antimicrob Agents Chemother 51:576-82. 2007
..1 mg/liter (sparfloxacin [SPX]) and 0.5 mg/liter (moxifloxacin [MXF], ciprofloxacin [CIP], and ofloxacin [OFX])...
- Dissemination of ST131 and ST393 community-onset, ciprofloxacin-resistant Escherichia coli clones causing urinary tract infections in Korea
Mi Young Lee
Asian Pacific Research Foundation for Infectious Diseases ARFID, Seoul, South Korea
J Infect 60:146-53. 2010
b>Ciprofloxacin-resistant Escherichia coli is growing concern in clinical settings. In this study, we investigated the distribution of virulence determinants and phylogenetic groups among community-onset, ciprofloxacin-resistant E...
- Shifting trends in bacterial keratitis in south Florida and emerging resistance to fluoroquinolones
Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA
Ophthalmology 107:1497-502. 2000
..To study the distribution, current trends, and patterns of resistance to antimicrobial agents of bacterial keratitis isolates in South Florida...
- Nursing homes as a reservoir of extended-spectrum beta-lactamase (ESBL)-producing ciprofloxacin-resistant Escherichia coli
Paul J Rooney
Department of Microbiology, Belfast City Hospital, Belfast BT9 7AD, UK
J Antimicrob Chemother 64:635-41. 2009
..To assess the prevalence and risk factors for faecal carriage of fluoroquinolone-resistant, extended-spectrum beta-lactamase (ESBL)-producing, Escherichia coli (MDR E. coli) among residents in nursing homes in Northern Ireland...
- Expansion and countrywide dissemination of ST11, ST15 and ST147 ciprofloxacin-resistant CTX-M-15-type beta-lactamase-producing Klebsiella pneumoniae epidemic clones in Hungary in 2005--the new 'MRSAs'?
Department of Phage Typing and Molecular Epidemiology, National Center for Epidemiology, Gyali ut 2 6, 1097 Budapest, Hungary
J Antimicrob Chemother 62:978-85. 2008
To investigate the molecular epidemiology of ciprofloxacin-resistant CTX-M-15-producing Klebsiella pneumoniae epidemic clones (ECs) isolated from six nosocomial outbreaks and sporadic cases during 2005 in Hungary.
- Quinolone-resistance mutations in the topoisomerase IV parC gene of Acinetobacter baumannii
Department of Microbiology, Hospital Clinic, School of Medicine, University of Barcelona, Spain
J Antimicrob Chemother 39:757-62. 1997
..baumannii and other bacteria. Nine of ten isolates with MICs of ciprofloxacin of > or = 32 mg/L showed a change of Ser80 to Leu and one showed a change of Glu84 to Lys...
- Effect of albumin conformation on the binding of ciprofloxacin to human serum albumin: a novel approach directly assigning binding site
Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh U P, India 202002
Biomacromolecules 7:1350-6. 2006
..8-5.2 M urea concentrations. These states displayed characteristic structure and functions. To elucidate the ciprofloxacin (CFX) binding behavior of HSA, the binding of ciprofloxacin with these conformational states of human serum ..
- Ciprofloxacin and trimethoprim cause phage induction and virulence modulation in Staphylococcus aureus
Institut fur Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Tubingen, Elfriede Aulhorn Str 6, 72076 Tubingen, Germany
Antimicrob Agents Chemother 50:171-7. 2006
..Here, we analyzed the effects of ciprofloxacin and trimethoprim on phage induction and expression of phage-encoded virulence factors by using isolates from ..
- Bacteremia due to Klebsiella pneumoniae isolates producing the TEM-52 extended-spectrum beta-lactamase: treatment outcome of patients receiving imipenem or ciprofloxacin
Laboratorio di Microbiologia, Ospedale di Circolo and Università dell Insubria, Varese, Italy
Clin Infect Dis 38:243-51. 2004
..as "nonfatal disease" using the McCabe and Jackson classification, were investigated with regard to ciprofloxacin and imipenem response...
- Real-time PCR detection of Pseudomonas aeruginosa in clinical and municipal wastewater and genotyping of the ciprofloxacin-resistant isolates
Forschungszentrum Karlsruhe, Department of Environmental Microbiology Water Technology and Geotechnology Division, Institute of Technical Chemistry, Karlsruhe, Germany
FEMS Microbiol Ecol 57:158-67. 2006
..Limitations of the detection system resulting from inhibition or cross-reaction were identified. Ciprofloxacin-resistant P...
- Ciprofloxacin selects for multidrug resistance in Salmonella enterica serovar Typhimurium mediated by at least two different pathways
University of Birmingham, UK
J Antimicrob Chemother 63:909-16. 2009
..The aim of this study was to understand the role of ramA in conferring multidrug resistance (MDR) in Salmonella enterica serovar Typhimurium...
- Trends in antimicrobial resistance among urinary tract infection isolates of Escherichia coli from female outpatients in the United States
James A Karlowsky
Focus Technologies, Inc, 13665 Dulles Technology Drive, Suite 200, Herndon, VA 20171 4603, USA
Antimicrob Agents Chemother 46:2540-5. 2002
..To determine trends in the activities of SXT, ampicillin, ciprofloxacin, and nitrofurantoin among urine isolates of Escherichia coli from female outpatients, susceptibility testing ..
- Ciprofloxacin-resistant Salmonella enterica serovar Typhimurium strains are difficult to select in the absence of AcrB and TolC
Antimicrobial Agents Research Group, Division of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
Antimicrob Agents Chemother 50:38-42. 2006
..Strains were exposed to ciprofloxacin at 2x the MIC in agar, in the presence and absence of Phe-Arg-beta-naphthylamide, an efflux pump inhibitor...
- Antibiotic usage and risk of colonization and infection with antibiotic-resistant bacteria: a hospital population-based study
Department of Infectious Diseases, Universita Cattolica del Sacro Cuore, Rome, Italy
Antimicrob Agents Chemother 53:4264-9. 2009
..methicillin (meticillin)-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and ciprofloxacin-resistant Pseudomonas aeruginosa (CR-PA)...
- Molecular characterization of ciprofloxacin-resistant Salmonella enterica serovar Typhi and Paratyphi A causing enteric fever in India
Department of Microbiology, Safdarjung Hospital and Assoc VMMC, New Delhi, India
J Antimicrob Chemother 58:1139-44. 2006
..To define the genetic characteristics and resistance mechanisms of clinical isolates of Salmonella enterica serovar Typhi (S. Typhi) and S. enterica serovar Paratyphi A (S. Paratyphi A) exhibiting high-level fluoroquinolones resistance...
- Beta-lactam susceptibilities and prevalence of ESBL-producing isolates among more than 5000 European Enterobacteriaceae isolates
Department of Internal Medicine, Division of Emergency Medicine and Infectious Diseases, F 02 126, University Medical Center Utrecht, P O Box 85000, 3508 GA Utrecht, The Netherlands
Int J Antimicrob Agents 24:585-91. 2004
..5% of all isolates). ESBL-production was confirmed with the ESBL-Etest and disk diffusion test in 1.3% of Escherichia coli isolates, 18.4% of Klebsiella pneumoniae, 12.6% of Klebsiella oxytoca and 5.3% of Proteus mirabilis isolates...
- Prevalence and risk factor analysis of trimethoprim-sulfamethoxazole- and fluoroquinolone-resistant Escherichia coli infection among emergency department patients with pyelonephritis
David A Talan
Department of Emergency Medicine, Olive View UCLA Medical Center, 14445 Olive View Dr, North Annex, Sylmar, CA 91342, USA
Clin Infect Dis 47:1150-8. 2008
..High rates of resistance to trimethoprim-sulfamethoxazole (TMP-SMX) among uropathogenic Escherichia coli are recognized, and concerns exist about emerging fluoroquinolone resistance...
- Community-acquired versus nosocomial Klebsiella pneumoniae bacteremia: clinical features, treatment outcomes, and clinical implication of antimicrobial resistance
Cheol In Kang
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
J Korean Med Sci 21:816-22. 2006
..33%, respectively, were extended-spectrum cephalosporin (ESC)-resistant, and 4% and 21%, respectively, were ciprofloxacin (CIP)-resistant...
- Travel-acquired salmonellosis due to Salmonella Kentucky resistant to ciprofloxacin, ceftriaxone and co-trimoxazole and associated with treatment failure
Jean Marc Collard
J Antimicrob Chemother 60:190-2. 2007
- The effects of anti-bacterials on the malaria parasite Plasmodium falciparum
Christopher Dean Goodman
Plant Cell Biology Research Centre, School of Botany, University of Melbourne, Parkville, Victoria 3010, Australia
Mol Biochem Parasitol 152:181-91. 2007
..This revealed two distinct classes of drug effect. Ciprofloxacin, rifampicin, and thiostrepton had an immediate effect: slowing parasite growth, retarding organellar ..
- The use of a novel biodegradable preparation capable of the sustained release of bacteriophages and ciprofloxacin, in the complex treatment of multidrug-resistant Staphylococcus aureus-infected local radiation injuries caused by exposure to Sr90
Tbilisi State Medical University, Tbilisi, Georgia, USA
Clin Exp Dermatol 30:23-6. 2005
..with PhagoBioDerm (a wound-healing preparation consisting of a biodegradable polymer impregnated with ciprofloxacin and bacteriophages) was initiated. Purulent drainage stopped within 2-7 days...
- Implementation of antibiotic rotation protocol improves antibiotic susceptibility profile in a surgical intensive care unit
Kyla M Bennett
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
J Trauma 63:307-11. 2007
..We assessed the effect of an antibiotic rotation protocol on the antibiotic susceptibility profiles of three clinically relevant gram-negative microorganisms within our surgical intensive care unit (SICU)...
- Interactions of ciprofloxacin with DPPC and DPPG: fluorescence anisotropy, ATR-FTIR and 31P NMR spectroscopies and conformational analysis
Universite Catholique de Louvain, Faculty of Medicine, Unité de Pharmacologie Cellulaire et Moléculaire, UCL 73 70, Avenue E Mounier 73, B 1200 Bruxelles, Belgium
Biochim Biophys Acta 1778:2535-43. 2008
..We previously showed that the ability of a fluoroquinolone antibiotic, ciprofloxacin, to induce disorder and modify the orientation of the acyl chains is related to its propensity to be expelled ..
- Characterisation of fluoroquinolone-resistant clinical isolates of Streptococcus pyogenes in Barcelona, Spain
Servei de Microbiologia, Hospital de la Santa Creu i Sant Pau, and Unitat de Microbiologia, Departament de Genetica i Microbiologia, Universitat Autonoma de Barcelona, Barcelona, Spain
Clin Microbiol Infect 11:759-61. 2005
..and clonal relationships were determined for six Streptococcus pyogenes isolates with low- or high-level ciprofloxacin resistance...
- Effects of ciprofloxacin on salt marsh sediment microbial communities
Ana Lucía Córdova-Kreylos
Department of Land, Air and Water Resources, University of California, Davis, CA, USA
ISME J 1:585-95. 2007
..The purpose of this study was to measure sorption, and effects of ciprofloxacin on microbial community composition, in sediment samples from three California salt marshes...
- High level of ciprofloxacin resistance and its molecular background among Campylobacter jejuni strains isolated in the United Arab Emirates
Department of Medical Microbiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
J Med Microbiol 55:1533-8. 2006
..5-4 mg l(-1)), 35 isolates (85.4 %) exhibited resistance to ciprofloxacin (MIC 8-64 mg l(-1))...
- Treatment failure in a typhoid patient infected with nalidixic acid resistant S. enterica serovar Typhi with reduced susceptibility to ciprofloxacin: a case report from Cameroon
Njinkeng J Nkemngu
St John s Maternity and Hospital, Fiango, Kumba, Cameroon
BMC Infect Dis 5:49. 2005
..Treatment failure with fluoroquinolones has been reported in Asia and Europe. We report a case of ciprofloxacin treatment failure in typhoid fever in Cameroon.
- Clonal emergence of extended-spectrum beta-lactamase (CTX-M-2)-producing Salmonella enterica serovar Virchow isolates with reduced susceptibilities to ciprofloxacin among poultry and humans in Belgium and France (2000 to 2003)
National Reference Centre for Salmonella and Shigella, Bacteriology Division, Scientific Institute of Public Health, 14 Wytsman Street, B 1050 Brussels, Belgium
J Clin Microbiol 44:2897-903. 2006
..additional resistance to trimethoprim-sulfamethoxazole and tetracycline as well as a reduced susceptibility to ciprofloxacin (MICs of between 0.5 and 1 mug/ml)...
- The effect of aging on migration, proliferation, and collagen expression of tenocytes in response to ciprofloxacin
Hsiang Ning Chang
Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taiwan
J Orthop Res 30:764-8. 2012
..Achilles tendon from two age groups (young: 2 months; and near senescent (old): 24 months) were treated with ciprofloxacin. Tenocyte migration and proliferation were assessed by transwell filter migration assay and MTT (3-[4,5-..
- Effect of generics on price and consumption of ciprofloxacin in primary healthcare: the relationship to increasing resistance
Ulrich S Jensen
National Center for Antimicrobials and Infection Control, Statens Serum Institut, Copenhagen, Denmark
J Antimicrob Chemother 65:1286-91. 2010
..In December 2001, generic ciprofloxacin was marketed in Denmark...
- Plasma and ear tissue concentrations of enrofloxacin and its metabolite ciprofloxacin in dogs with chronic end-stage otitis externa after intravenous administration of enrofloxacin
Lynette K Cole
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210, USA
Vet Dermatol 20:51-9. 2009
The purpose of this study was to measure the concentrations of enrofloxacin and its metabolite ciprofloxacin following intravenous administration of enrofloxacin in the plasma and ear tissue of dogs with chronic end-stage otitis ..
- Endocarditis caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: emergence of resistance to ciprofloxacin and piperacillin-tazobactam during treatment despite initial susceptibility
Division of Infectious Diseases, Kaplan Medical Center Rehovot, Hebrew University and Hadassah, Jerusalem, Israel
Antimicrob Agents Chemother 50:3179-82. 2006
..The second isolate developed resistance to ciprofloxacin and the third isolate to piperacillin-tazobactam (PIP-TZ) following sequential therapy with each agent...
- Treatment of staphylococcal implant infection with rifampicin-ciprofloxacin in stable implants
D P Konig
Department of Orthopaedic Surgery, Cologne University, Germany
Arch Orthop Trauma Surg 121:297-9. 2001
..as in patients who for certain reasons are inoperable, antibiotic therapy with a combination of rifampicin-ciprofloxacin may be a reasonable treatment option for curing staphyloccocal infection without removal of the implant...
- Oxidative stress induced by ciprofloxacin in Staphylococcus aureus
M C Becerra
Departamento de Farmacia, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, 5000 Cordoba, Argentina
Biochem Biophys Res Commun 297:1003-7. 2002
Staphylococcus aureus with multiple sensitivity to ciprofloxacin, was investigated to detect alterations in the production of superoxide anion (O(2)(-)), other reactive oxidant species (ROS), and superoxide dismutase (SOD), and to relate ..
- Spontaneous mutation frequency and emergence of ciprofloxacin resistance in Campylobacter jejuni and Campylobacter coli
Marja Liisa Hänninen
Department of Food and Environmental Hygiene, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland
J Antimicrob Chemother 60:1251-7. 2007
We analysed the contribution of spontaneous mutation frequency to the evolution of ciprofloxacin resistance and the diversity of mutations in the quinolone resistance-determining region (QRDR) of gyrA and in the intergenic region, cmeR-..
- Clonal spread in Eastern Asia of ciprofloxacin-resistant Escherichia coli serogroup O25 strains, and associated virulence factors
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Int J Antimicrob Agents 35:444-50. 2010
..coli recently became prevalent at least in East Asia and suggest that this might become a public health problem because the strains may acquire resistance to other antimicrobial agents...
- Activity and postantibiotic effect of marbofloxacin, enrofloxacin, difloxacin and ciprofloxacin against feline Bordetella bronchiseptica isolates
Istituto di Microbiologia, Facolta di Medicina e Chirurgia, Policlinico Universitario, Torre Biologica, 2 degrees piano, Universita di Messina, 98125, Messina, Italy
Vet Microbiol 81:79-84. 2001
..inhibitory concentration (MIC) and postantibiotic effect (PAE) of marbofloxacin, enrofloxacin, difloxacin and ciprofloxacin were evaluated in vitro against 43 feline-source Bordetella bronchiseptica strains...
- Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism
Marika T Granfors
Department of Clinical Pharmacology, University of Helsinki, FIN 00290 Helsinki, Finland
Clin Pharmacol Ther 76:598-606. 2004
..The fluoroquinolone antibiotic ciprofloxacin is only a moderately potent inhibitor of CYP1A2...
- Efficacy of ciprofloxacin-releasing bioabsorbable osteoconductive bone defect filler for treatment of experimental osteomyelitis due to Staphylococcus aureus
Jyri K Koort
Orthopaedic Research Unit, Department of Orthopaedic Surgery and Traumatology, University of Turku, FIN 20520 Turku, Finland
Antimicrob Agents Chemother 49:1502-8. 2005
..After removal of the bone cement and surgical debridement at 2 weeks, the defect was filled with a ciprofloxacin-containing (7.6% +/- 0...
- Review of resistance of ocular isolates of Pseudomonas aeruginosa and staphylococci from keratitis to ciprofloxacin, gentamicin and cephalosporins
Mark D P Willcox
School of Optometry and Vision Science, University of New South Wales, Sydney NSW 2052, Australia
Clin Exp Optom 94:161-8. 2011
..Antibiotic therapy to treat keratitis caused by these bacteria is either monotherapy with a fluoroquinolone or combination therapy with fortified gentamicin...
- In vivo selection of Campylobacter isolates with high levels of fluoroquinolone resistance associated with gyrA mutations and the function of the CmeABC efflux pump
Food Animal Health Research Program, Ohio Agricultural Research and Development Center, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, Ohio 44691, USA
Antimicrob Agents Chemother 47:390-4. 2003
..These results reveal that Campylobacter is hypermutable in vivo under the selection pressure of FQ and highlight the need for the prudent use of FQ antibiotics...