tetrodotoxin

Summary

Summary: An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.

Top Publications

  1. ncbi Activity-dependent scaling of quantal amplitude in neocortical neurons
    G G Turrigiano
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254, USA
    Nature 391:892-6. 1998
  2. ncbi Rapid synaptic scaling induced by changes in postsynaptic firing
    Keiji Ibata
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
    Neuron 57:819-26. 2008
  3. pmc Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel
    M E Gellens
    Department of Medicine, University of Pennsylvania, Philadelphia 19104
    Proc Natl Acad Sci U S A 89:554-8. 1992
  4. ncbi Synaptic scaling mediated by glial TNF-alpha
    David Stellwagen
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304 5485, USA
    Nature 440:1054-9. 2006
  5. pmc Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors
    Jason D Shepherd
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 52:475-84. 2006
  6. ncbi Traumatic axonal injury induces calcium influx modulated by tetrodotoxin-sensitive sodium channels
    J A Wolf
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 21:1923-30. 2001
  7. ncbi Action potential generation requires a high sodium channel density in the axon initial segment
    Maarten H P Kole
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Garran Road, Canberra ACT 0200, Australia
    Nat Neurosci 11:178-86. 2008
  8. pmc The chemical and evolutionary ecology of tetrodotoxin (TTX) toxicity in terrestrial vertebrates
    Charles T Hanifin
    Hopkins Marine Station of Stanford University, 120 Oceanview Blvd, Pacific Grove, CA 93950, USA
    Mar Drugs 8:577-93. 2010
  9. ncbi Postsynaptic expression of homeostatic plasticity at neocortical synapses
    Corette J Wierenga
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Neurosci 25:2895-905. 2005
  10. pmc CDK5 serves as a major control point in neurotransmitter release
    Sung Hyun Kim
    Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA
    Neuron 67:797-809. 2010

Detail Information

Publications326 found, 100 shown here

  1. ncbi Activity-dependent scaling of quantal amplitude in neocortical neurons
    G G Turrigiano
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254, USA
    Nature 391:892-6. 1998
    ....
  2. ncbi Rapid synaptic scaling induced by changes in postsynaptic firing
    Keiji Ibata
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
    Neuron 57:819-26. 2008
    ....
  3. pmc Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel
    M E Gellens
    Department of Medicine, University of Pennsylvania, Philadelphia 19104
    Proc Natl Acad Sci U S A 89:554-8. 1992
    ..homologous to other members of the sodium channel multigene family and bears greater than 90% identity to the tetrodotoxin-insensitive sodium channel characteristic of rat heart and of immature and denervated rat skeletal muscle...
  4. ncbi Synaptic scaling mediated by glial TNF-alpha
    David Stellwagen
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304 5485, USA
    Nature 440:1054-9. 2006
    ..We suggest that by modulating TNF-alpha levels, glia actively participate in the homeostatic activity-dependent regulation of synaptic connectivity...
  5. pmc Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors
    Jason D Shepherd
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 52:475-84. 2006
    ..1 is required for memory consolidation, reveal the importance of Arc/Arg3.1's dynamic expression as it exerts continuous and precise control over synaptic strength and cellular excitability...
  6. ncbi Traumatic axonal injury induces calcium influx modulated by tetrodotoxin-sensitive sodium channels
    J A Wolf
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 21:1923-30. 2001
    ..change in intra-axonal calcium was completely abolished by the application of the sodium channel blocker tetrodotoxin or by replacement of sodium with N-methyl-d-glucamine...
  7. ncbi Action potential generation requires a high sodium channel density in the axon initial segment
    Maarten H P Kole
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Garran Road, Canberra ACT 0200, Australia
    Nat Neurosci 11:178-86. 2008
    ..In conclusion, action potential generation requires a high Na(+) channel density at the AIS, which is maintained by tight anchoring to the actin cytoskeleton...
  8. pmc The chemical and evolutionary ecology of tetrodotoxin (TTX) toxicity in terrestrial vertebrates
    Charles T Hanifin
    Hopkins Marine Station of Stanford University, 120 Oceanview Blvd, Pacific Grove, CA 93950, USA
    Mar Drugs 8:577-93. 2010
    b>Tetrodotoxin (TTX) is widely distributed in marine taxa, however in terrestrial taxa it is limited to a single class of vertebrates (Amphibia)...
  9. ncbi Postsynaptic expression of homeostatic plasticity at neocortical synapses
    Corette J Wierenga
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Neurosci 25:2895-905. 2005
    ....
  10. pmc CDK5 serves as a major control point in neurotransmitter release
    Sung Hyun Kim
    Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA
    Neuron 67:797-809. 2010
    ..These studies thus pinpoint CDK5 as a major control point for modulation of neurotransmitter release in mammalian neurons...
  11. ncbi Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures
    Katharina Zimmermann
    Department of Physiology and Pathophysiology, Faculty of Medicine, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
    Nature 447:855-8. 2007
    ..that this goal is achieved by endowing superficial endings of slowly conducting nociceptive fibres with the tetrodotoxin-resistant voltage-gated sodium channel (VGSC) Na(v)1.8 (ref. 2)...
  12. ncbi Multiple forms of synaptic plasticity triggered by selective suppression of activity in individual neurons
    Juan Burrone
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 420:414-8. 2002
    ..Our results highlight the differences between global and selective suppression of activity, as well as those between early and late manipulation of activity...
  13. pmc The TTX-resistant sodium channel Nav1.8 (SNS/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neurons
    Laiche Djouhri
    Department of Physiology, University of Bristol Medical School, Bristol BS8 1TD, UK
    J Physiol 550:739-52. 2003
    ..Thus high levels of Nav1.8 protein may contribute to the longer AP durations (especially in A-fibre neurons) and larger AP overshoots that are typical of nociceptors...
  14. ncbi The presence and role of the tetrodotoxin-resistant sodium channel Na(v)1.9 (NaN) in nociceptive primary afferent neurons
    Xin Fang
    Department of Physiology, University of Bristol, Medical School, Bristol BS8 1TD, United Kingdom
    J Neurosci 22:7425-33. 2002
    ..The data provide direct evidence that Na(v)1.9 is expressed selectively in (but not in all) C- and A-fiber nociceptive-type units and suggest that Na(v)1.9 contributes to membrane properties that are typical of nociceptive neurons...
  15. ncbi Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain
    Michael S Gold
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 23:158-66. 2003
    ..These observations suggest that aberrant activity in uninjured C-fibers is a necessary component of pain associated with partial nerve injury. They also suggest that blocking Na(V)1.8 would be an effective treatment of neuropathic pain...
  16. ncbi Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain
    Joel A Black
    Department of Neurology and Paralyzes Veterans of America, Eastern Paralyzed Veterans Association Neuroscience Research Center, Yale University School of Medicine, New Haven CT 06510, USA
    Pain 108:237-47. 2004
    ..Nociceptive neurons within dorsal root ganglia (DRG) express multiple voltage-gated sodium channels, of which the tetrodotoxin-resistant (TTX-R) channel Na(v)1.8 has been suggested to play a major role in inflammatory pain...
  17. pmc Tetrodotoxin--distribution and accumulation in aquatic organisms, and cases of human intoxication
    Tamao Noguchi
    Tokyo Health Care University, 3 11 3, Setagaya, Tokyo 154 8568, Japan
    Mar Drugs 6:220-42. 2008
    Many pufferfish of the family Tetraodontidae possess a potent neurotoxin, tetrodotoxin (TTX)...
  18. ncbi PGE2 increases the tetrodotoxin-resistant Nav1.9 sodium current in mouse DRG neurons via G-proteins
    Anthony M Rush
    Department of Neurology, Yale University School of Medicine, LCI 707, 333 Cedar St, New Haven, CT 06510, USA
    Brain Res 1023:264-71. 2004
    ..The tetrodotoxin-resistant (TTX-R) sodium channel Na(v)1...
  19. ncbi Roles of tetrodotoxin (TTX)-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons
    Nathaniel T Blair
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 20114, USA
    J Neurosci 22:10277-90. 2002
    ..are unusual in expressing voltage-gated inward currents carried by sodium channels resistant to block by tetrodotoxin (TTX) as well as currents carried by conventional TTX-sensitive sodium channels and voltage-dependent calcium ..
  20. pmc Inflammatory mediators increase Nav1.9 current and excitability in nociceptors through a coincident detection mechanism
    Francois Maingret
    CRN2M, CNRS, Universit é de la M é diterran é e, 13916 Marseille Cedex 20, France
    J Gen Physiol 131:211-25. 2008
    ..We conclude that Nav1.9 channel, the molecular correlate of the NaN current, is potentiated by the concerted action of inflammatory mediators that may contribute to nociceptors' hyperexcitability during peripheral inflammation...
  21. pmc The tetrodotoxin binding site is within the outer vestibule of the sodium channel
    Harry A Fozzard
    Department of Medicine, University of Chicago Hospitals, Chicago, IL 60637, USA
    Mar Drugs 8:219-34. 2010
    b>Tetrodotoxin and saxitoxin are small, compact asymmetrical marine toxins that block voltage-gated Na channels with high affinity and specificity...
  22. pmc muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits
    J Ekberg
    Institute for Molecular Bioscience and School of Biomedical Sciences, University of Queensland, QLD 4072, Australia
    Proc Natl Acad Sci U S A 103:17030-5. 2006
    The tetrodotoxin-resistant voltage-gated sodium channel (VGSC) Na(v)1.8 is expressed predominantly by damage-sensing primary afferent nerves and is important for the development and maintenance of persistent pain states...
  23. pmc Early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in dorsal root ganglion neurons in the rat
    Shuangsong Hong
    Department of Internal Medicine and Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 279:29341-50. 2004
    ..Alterations in the expression and function of voltage-gated tetrodotoxin-resistant (TTX-R) sodium channels have been implicated in animal models of neuropathic pain, including models ..
  24. ncbi Involvement of the TTX-resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post-operative, pain states
    S K Joshi
    Abbott Laboratories, Neuroscience Research, Abbott Park, IL 60064, USA
    Pain 123:75-82. 2006
    ..6+/-6.2% effect, p<0.05 vs. MM). These data demonstrate a greater involvement of Nav 1.8 in frank nerve injury and inflammatory pain as compared to acute, post-operative or chemotherapy-induced neuropathic pain states...
  25. ncbi Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwena
    Kuan Peng
    College of Life Sciences, Hunan Normal University, Changsha 410081, People s Republic of China
    J Biol Chem 277:47564-71. 2002
    ..It specifically inhibits the neuronal tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channel with the IC(50) value of 30 nm in adult rat dorsal root ganglion ..
  26. ncbi Presynaptic Na+ channels: locus, development, and recovery from inactivation at a high-fidelity synapse
    Ricardo M Leão
    The Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci 25:3724-38. 2005
    ..We propose that the high density and polarized locus of Na+ channels on a long heminode are critical design features that allow the mature calyx of Held terminal to fire reliably at frequencies near 1 kHz...
  27. ncbi Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP
    V Monica Bricelj
    Institute for Marine Biosciences, National Research Council, Halifax, Nova Scotia B3H 3Z1, Canada
    Nature 434:763-7. 2005
    ..Furthermore, global expansion of PSP to previously unaffected coastal areas might result in long-term changes to communities and ecosystems...
  28. ncbi Detection of tetrodotoxin from the grey side-gilled sea slug - Pleurobranchaea maculata, and associated dog neurotoxicosis on beaches adjacent to the Hauraki Gulf, Auckland, New Zealand
    Paul McNabb
    Cawthron Institute, Private Bag 2, Nelson, 7001, New Zealand
    Toxicon 56:466-73. 2010
    ..a series of dog poisonings on beaches in Auckland, North Island, New Zealand, resulted in the identification of tetrodotoxin (TTX) in the grey side-gilled sea slug, Pleurobranchaea maculata. The levels of TTX in P...
  29. ncbi Interleukin-1beta induces hyperpolarization and modulates synaptic inhibition in preoptic and anterior hypothalamic neurons
    I V Tabarean
    Harold L Dorris Neurological Research Center, Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuroscience 141:1685-95. 2006
    ..Taken together our data suggest that IL-1beta inhibits the activity of preoptic area/anterior hypothalamus neurons by increasing the presynaptic release of GABA...
  30. ncbi The molecular mystique of tetrodotoxin
    Edward G Moczydlowski
    Nanobiology, Sandia National Laboratories, P O Box 5800, MS1413, Albuquerque, NM 87185 1413, USA
    Toxicon 63:165-83. 2013
    In many respects tetrodotoxin (TTX) is the quintessential natural toxin...
  31. ncbi Depuration of tetrodotoxin and changes in bacterial communities in Pleurobranchea maculata adults and egg masses maintained in captivity
    Susanna A Wood
    Cawthron Institute, Nelson, New Zealand
    J Chem Ecol 38:1342-50. 2012
    Depuration of tetrodotoxin (TTX) was investigated in adult grey side-gilled sea slugs, Pleurobranchaea maculata, maintained in captivity on a TTX-free diet...
  32. pmc Tetrodotoxin-resistant voltage-dependent sodium channels in identified muscle afferent neurons
    Renuka Ramachandra
    The Baker Laboratory of Pharmacology, Department of Pharmacology, Kirksville College of Osteopathic Medicine, AT Still University of Health Sciences, Kirksville, MO 63501, USA
    J Neurophysiol 108:2230-41. 2012
    ..recordings, we found that the dominant Na(V) current in the majority of identified neurons was insensitive to tetrodotoxin (TTX-R), with Na(V) current in only a few (14%) neurons showing substantial (>50%) TTX sensitivity (TTX-S)...
  33. pmc Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes
    Chris R Feldman
    Department of Biology, University of Nevada, Reno, NV 89557, USA
    Proc Natl Acad Sci U S A 109:4556-61. 2012
    ..We demonstrate remarkably constrained convergence during the evolution of resistance to the lethal poison, tetrodotoxin, in six snake species representing three distinct lineages from around the globe...
  34. ncbi Sodium channel blockade may contribute to the analgesic efficacy of antidepressants
    Ivy E Dick
    Department of Ion Channels, Merck Research Laboratories, Rahway, New Jersey 07065 0900, USA
    J Pain 8:315-24. 2007
    ..In the current study, we compared the potency of peripheral sodium channel blockade for several tricyclic antidepressants and selective serotonin reuptake inhibitors with their therapeutic efficacy...
  35. ncbi Mu-conotoxin SmIIIA, a potent inhibitor of tetrodotoxin-resistant sodium channels in amphibian sympathetic and sensory neurons
    Peter J West
    Interdepartmental Program in Neuroscience and Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 41:15388-93. 2002
    ..dissociated neurons from frog sympathetic and dorsal root ganglia, the peptide inhibited the majority of tetrodotoxin-resistant sodium currents irreversibly; in contrast, tetrodotoxin-sensitive sodium currents were largely ..
  36. pmc Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes
    Xianming Lin
    Leon H Charney Division of Cardiology, New York University School of Medicine, New York, New York 10016, USA
    Heart Rhythm 8:1923-30. 2011
    ..Sodium channel α-subunits in ventricular myocytes (VMs) segregate either to the intercalated disc or to lateral membranes, where they associate with region-specific molecules...
  37. ncbi Ontogeny of tetrodotoxin levels in blue-ringed octopuses: maternal investment and apparent independent production in offspring of Hapalochlaena lunulata
    Becky L Williams
    Department of Biology, New Mexico State University, Las Cruces, NM 88003 8001, USA
    J Chem Ecol 37:10-7. 2011
    ..Adult blue-ringed octopuses (Hapalochlaena spp.) harbor tetrodotoxin (TTX), which may be produced by symbiotic bacteria...
  38. ncbi Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8
    Josephine Lai
    Department of Pharmacology, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Pain 95:143-52. 2002
    ..we show that intrathecal administration of specific antisense oligodeoxynucleotides (ODN) to the peripheral tetrodotoxin (TTX)-resistant sodium channel, NaV1...
  39. pmc Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models
    W Xie
    Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0531, USA
    Neuroscience 160:847-57. 2009
    ..Perfusion of the axotomized DRG with the Na channel blocker tetrodotoxin (TTX) significantly reduced this activation at all time points...
  40. ncbi A novel conotoxin from Conus striatus, mu-SIIIA, selectively blocking rat tetrodotoxin-resistant sodium channels
    Cheng Zhong Wang
    Key Laboratory of Proteomics, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Toxicon 47:122-32. 2006
    Mu-conotoxin SIIIA, a novel blocker of tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels (VGSCs) has been identified from the fish-hunting cone snail, Conus striatus...
  41. ncbi Temporal regulation of the expression locus of homeostatic plasticity
    Corette J Wierenga
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
    J Neurophysiol 96:2127-33. 2006
    ....
  42. pmc Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory circuits adapting to inactivity
    Ananya Mitra
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, USA
    Nat Neurosci 15:250-7. 2012
    ..Chronic tetrodotoxin treatment greatly reduced the percentage of connected CA3-CA3 neurons, but enhanced the strength of the ..
  43. pmc Homeostatic regulation of AMPA receptor trafficking and degradation by light-controlled single-synaptic activation
    Qingming Hou
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Neuron 72:806-18. 2011
    ..These results indicate that AMPAR accumulation at individual synapses is subject to autonomous homeostatic regulation in response to synaptic activity...
  44. ncbi Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-alpha
    Xiaochun Jin
    Washington University Pain Center, Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 26:246-55. 2006
    ..Because tetrodotoxin (TTX)-resistant Na+ channels are a critical site of modulation underlying mechanical hypersensitivity in ..
  45. ncbi On the origins and biosynthesis of tetrodotoxin
    Rocky Chau
    School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW 2052, Australia
    Aquat Toxicol 104:61-72. 2011
    The potent neurotoxin tetrodotoxin (TTX) has been identified from taxonomically diverse marine organisms. TTX possesses a unique cage-like structure, however, its biosynthesis has yet to be elucidated...
  46. ncbi A new tetrodotoxin-producing actinomycete, Nocardiopsis dassonvillei, isolated from the ovaries of puffer fish Fugu rubripes
    Zhenlong Wu
    Department of Biological Science and Biotechnology, Tsinghua University, Beijing, P R China
    Toxicon 45:851-9. 2005
    Three puffer fishes, Fugu rubripes, collected from the Bohai Sea of China were examined for tetrodotoxin-producing microorganisms. An actinomycete isolated from the ovaries of the puffer fishes was found to produce tetrodotoxin...
  47. ncbi Acute tetrodotoxin-induced neurotoxicity after ingestion of puffer fish
    Matthew C Kiernan
    Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, Sydney NSW 2031, Australia
    Ann Neurol 57:339-48. 2005
    ..The urine of each patient tested positive for tetrodotoxin. Compared with controls, axons were of higher threshold, compound muscle action potentials and compound sensory ..
  48. pmc Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes
    Jonathan Satin
    Department of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536 0298, USA
    J Physiol 559:479-96. 2004
    ..5; thus, the NaV1.5 Na+ channel is important for initiating spontaneous excitability in hES-derived heart cells...
  49. ncbi The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
    A N Akopian
    Molecular Nociception Group, Department of Biology, Medawar Building, University College, London WC1E 6BT, UK
    Nat Neurosci 2:541-8. 1999
    Many damage-sensing neurons express tetrodotoxin (TTX)-resistant voltage-gated sodium channels...
  50. pmc GTP-induced tetrodotoxin-resistant Na+ current regulates excitability in mouse and rat small diameter sensory neurones
    Mark D Baker
    Molecular Nociception Group, Department of Biology, Medawar Building, University College London, Gower Street, UK
    J Physiol 548:373-82. 2003
    ..We have found that a low-threshold, persistent tetrodotoxin-resistant Na+ current, attributed to NaV1...
  51. ncbi Antinociceptive effects of tetrodotoxin (TTX) in rodents
    J Marcil
    Department of Anesthesiology, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Br J Anaesth 96:761-8. 2006
    b>Tetrodotoxin (TTX) is a powerful sodium channel blocker extracted from the puffer fish. The analgesic effects of TTX were investigated in different animal pain models.
  52. pmc Nonequilibrium calcium dynamics regulate the autonomous firing pattern of rat striatal cholinergic interneurons
    Joshua A Goldberg
    Department of Biology, University of Texas at San Antonio, San Antonio, Texas 78249, USA
    J Neurosci 29:8396-407. 2009
    ..During irregular firing, calcium entry at both timescales can be detected, suggesting that an interaction between the medium and slow calcium-dependent afterhyperpolarizations may underlie this firing pattern...
  53. pmc Distinct frequency preferences of different types of rat hippocampal neurones in response to oscillatory input currents
    F G Pike
    Departments of Physiology and Pharmacology, and MRC Anatomical Neuropharmacology Unit, Oxford, UK
    J Physiol 529:205-13. 2000
    ..Therefore, in the CA1 layer of the hippocampal network, a compound oscillatory input may be segregated into distinct frequency components which are processed locally by distinct types of neurones...
  54. ncbi Sodium channels contribute to microglia/macrophage activation and function in EAE and MS
    Matthew J Craner
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale School of Medicine, New Haven, Connecticut 06520 8018, USA
    Glia 49:220-9. 2005
    ..Supporting a role for sodium channels in microglial activation, we show that tetrodotoxin, a specific sodium channel blocker, reduces the phagocytic function of activated rat microglia by 40%...
  55. ncbi Directional movement of rat prostate cancer cells in direct-current electric field: involvement of voltagegated Na+ channel activity
    - Djamgoz MBA
    Department of Biology, Imperial College of Science, Technology and Medicine, London, UK
    J Cell Sci 114:2697-705. 2001
    ..channel activity was modulated pharmacologically using a range of concentrations of a specific channel blocker (tetrodotoxin) or an opener (veratridine)...
  56. ncbi Selective expression of a persistent tetrodotoxin-resistant Na+ current and NaV1.9 subunit in myenteric sensory neurons
    Francois Rugiero
    Intégration des Informations Sensorielles, Unite Mixte de Recherche 6150, Centre National de la Recherche Scientifique, 13916 Marseille, France
    J Neurosci 23:2715-25. 2003
    ..TTX-R I(Na) may play an important role in regulating subthreshold electrogenesis and boosting synaptic stimuli, thereby conferring distinct integrative properties to myenteric sensory neurons...
  57. ncbi Light-emitting diode treatment reverses the effect of TTX on cytochrome oxidase in neurons
    M T Wong-Riley
    Department of Cell Biology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuroreport 12:3033-7. 2001
    ..LED was administered to cultured primary neurons whose voltage-dependent sodium channels were blocked by tetrodotoxin. The down-regulation of cytochrome oxidase activity by TTX was reverted to control levels by LED...
  58. ncbi NaN/Nav1.9: a sodium channel with unique properties
    Sulayman Dib-Hajj
    Department of Neurology and PVA EPVA Neuroscience Research Center, Yale University School of Medicine, New Haven, CT 06510, USA
    Trends Neurosci 25:253-9. 2002
    ..Na(v)1.9 produces a persistent, tetrodotoxin-resistant current with wide overlap between activation and steady-state inactivation, and appears to modulate ..
  59. ncbi Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis
    Scott P Fraser
    Neuroscience Solutions to Cancer Research Group, Department of Biological Sciences, Imperial College London, UK
    Clin Cancer Res 11:5381-9. 2005
    ..The purpose of this study was to investigate voltage-gated Na(+) channel (VGSC) expression and its possible role in human breast cancer...
  60. ncbi The changes in expression of three subtypes of TTX sensitive sodium channels in sensory neurons after spinal nerve ligation
    C H Kim
    Marine Biomedical Institute and Department of Anatomy and Neurosciences, University of Texas Medical Branch at Galveston, 77555-1069, USA
    Brain Res Mol Brain Res 95:153-61. 2001
    ..that developed after spinal nerve ligation were significantly reduced by application of a low concentration of tetrodotoxin (TTX) to the corresponding dorsal root ganglion (DRG) of the ligated spinal nerve...
  61. ncbi Contrasting effects of the persistent Na+ current on neuronal excitability and spike timing
    Koen Vervaeke
    Department of Physiology, Institute of Basal Medicine, University of Oslo, PB 1103 Blindern, N 0317 Oslo, Norway
    Neuron 49:257-70. 2006
    ..Finally, model simulations demonstrated that I(NaP) increased the relative refractory period and decreased interspike-interval variability under conditions resembling an active network in vivo...
  62. pmc Protein kinase C mediates up-regulation of tetrodotoxin-resistant, persistent Na+ current in rat and mouse sensory neurones
    Mark D Baker
    Molecular Nociception Group, Department of Biology, Medawar Building, University College London, UK
    J Physiol 567:851-67. 2005
    The tetrodotoxin-resistant (TTX-r) persistent Na(+) current, attributed to Na(V)1.9, was recorded in small (< 25 mum apparent diameter) dorsal root ganglion (DRG) neurones cultured from P21 rats and from adult wild-type and Na(V)1...
  63. ncbi Isolation and characterization of hainantoxin-IV, a novel antagonist of tetrodotoxin-sensitive sodium channels from the Chinese bird spider Selenocosmia hainana
    Z Liu
    College of Life Sciences, Hunan Normal University, Changsha 410081 Hunan, China
    Cell Mol Life Sci 60:972-8. 2003
    ..huwena, a potent antagonist that acts at site 1 on tetrodotoxin-sensitive (TTX-S) sodium channels, suggesting that hainantoxin-IV adopts an inhibitor cystine knot structural ..
  64. ncbi Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels
    Katherine J Nielsen
    Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia
    J Biol Chem 277:27247-55. 2002
    ..Synthetic forms of mu-conotoxins PIIIA and PIIIA-(2-22) were found to inhibit tetrodotoxin (TTX)-sensitive VSSC current but had little effect on TTX-resistant VSSC current in sensory ganglion neurons...
  65. ncbi Tetrodotoxin-resistant conductivity and spinal effects of cutaneous C-fibre afferents in the rat
    H Steffens
    Institut fur Anatomie und Zellbiologie, Universitat Heidelberg, Im Neuenheimer Feld 307, D 69120, Heidelberg, Germany
    Neurosci Res 39:413-9. 2001
    The effect of the sodium channel blocking agent tetrodotoxin (TTX) on signal processing in afferent fibres of dorsal roots was tested in Sprague-Dawley rats...
  66. ncbi Ion channels associated with the ectopic discharges generated after segmental spinal nerve injury in the rat
    X Liu
    Marine Biomedical Institute, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-1069, USA
    Brain Res 900:119-27. 2001
    ..The main focus of the study was to examine the effect of the sodium channel blocker, tetrodotoxin (TTX), in order to identify important subtype(s) (i.e...
  67. ncbi Role of tetrodotoxin-resistant Na+ current slow inactivation in adaptation of action potential firing in small-diameter dorsal root ganglion neurons
    Nathaniel T Blair
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:10338-50. 2003
    ..Thus, slow inactivation of the TTX-R sodium current limits the duration of small DRG cell firing in response to maintained stimuli and may contribute to cross desensitization between chemical and electrical stimuli...
  68. pmc Effect of Na(+) flow on Cd(2+) block of tetrodotoxin-resistant Na(+) channels
    Chung Chin Kuo
    Department of Physiology, National Taiwan University College of Medicine Department of Neurology, National Taiwan University Hospital, Taiwan
    J Gen Physiol 120:159-72. 2002
    b>Tetrodotoxin-resistant (TTX-R) Na(+) channels are 1,000-fold less sensitive to TTX than TTX-sensitive (TTX-S) Na(+) channels. On the other hand, TTX-R channels are much more susceptible to external Cd(2+) block than TTX-S channels...
  69. ncbi Neuronal activity is required for the circadian rhythm of vasopressin gene transcription in the suprachiasmatic nucleus in vitro
    Hiroshi Arima
    Developmental Endocrinology Brach, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 143:4165-71. 2002
    ..Inhibition of spontaneous activity by the sodium channel blocker, tetrodotoxin (TTX), dramatically decreased AVP heteronuclear RNA levels and suppressed rhythmicity, indicating that ongoing ..
  70. ncbi Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice
    Francisco Rafael Nieto
    Department of Pharmacology and Institute of Neuroscience, Faculty of Medicine, University of Granada, Avenida de Madrid 11, 18012 Granada, Spain
    Pain 137:520-31. 2008
    We evaluated the effect of low doses of systemically administered tetrodotoxin (TTX) on the development and expression of neuropathic pain induced by paclitaxel in mice. Treatment with paclitaxel (2mg/kg, i.p...
  71. pmc Tetrodotoxin sensitivity of the vertebrate cardiac Na+ current
    Matti Vornanen
    Department of Biology, University of Eastern Finland, Joensuu, Finland
    Mar Drugs 9:2409-22. 2011
    Evolutionary origin and physiological significance of the tetrodotoxin (TTX) resistance of the vertebrate cardiac Na(+) current (I(Na)) is still unresolved...
  72. ncbi Lessepsian migration and tetrodotoxin poisoning due to Lagocephalus sceleratus in the eastern Mediterranean
    Yedidia Bentur
    Israel Poison Information Center, Rambam Health Care Campus, The Rappaport Faculty of Medicine, Technion Israel Institute of Technology, PO Box 9602, Haifa 31096, Israel
    Toxicon 52:964-8. 2008
    ..The Suez Canal permits migration of fish from the Indo-Pacific Ocean to the Mediterranean Sea. This phenomenon (Lessepsian migration) has enabled poisonous fish species to colonize the Mediterranean Sea...
  73. ncbi Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice
    Lina Yao
    Department of Biology, Gilead Sciences, Palo Alto, California 94304, USA
    Am J Physiol Cell Physiol 301:C577-86. 2011
    ..effects of both ATX-II and the N(1325)S mutation were reversed by either I(NaL) inhibition (with ranolazine or tetrodotoxin) or CaMKII inhibition (with KN93 or autocamtide 2-related inhibitory peptide)...
  74. pmc Two types of cone bipolar cells express voltage-gated Na+ channels in the rat retina
    Jinjuan Cui
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Vis Neurosci 25:635-45. 2008
    ..Both groups of Na+-expressing bipolar cells were capable of generating a rapid tetrodotoxin-sensitive action potential as revealed by current injection...
  75. ncbi Tetrodotoxin levels in larval and metamorphosed newts (Taricha granulosa) and palatability to predatory dragonflies
    Brian G Gall
    Department of Biology, Utah State University, 5305 Old Main Hill, Logan, UT 84322, USA
    Toxicon 57:978-83. 2011
    Some populations of the newt Taricha granulosa possess extremely high concentrations of the neurotoxin tetrodotoxin (TTX). Tetrodotoxin is present in adult newts and their eggs, but has been assumed to be absent from the larval stage...
  76. pmc Tetrodotoxin reduces cue-induced drug craving and anxiety in abstinent heroin addicts
    Jie Shi
    National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Pharmacol Biochem Behav 92:603-7. 2009
    b>Tetrodotoxin (TTX) is a neurotoxin found in puffer fish and other marine animals. New clinical studies suggest that low-dose TTX can safely relieve severe, treatment-resistant cancer pain...
  77. ncbi First report on toxicity assessment of the Lessepsian migrant pufferfish Lagocephalus sceleratus (Gmelin, 1789) from European waters (Aegean Sea, Greece)
    Panagiota Katikou
    National Reference Laboratory of Marine Biotoxins, Institute of Food Hygiene, Ministry of Rural Development and Food, 3A Limnou Street, 54627 Thessaloniki, Greece
    Toxicon 54:50-5. 2009
    ..sceleratus specimens of different sizes were examined by means of the official mouse bioassay for tetrodotoxin, while some of the extracts were also tested for the presence of Paralytic Shellfish Poisoning (PSP) toxins ..
  78. ncbi Identification of a novel M-superfamily conotoxin with the ability to enhance tetrodotoxin sensitive sodium currents
    Lei Wang
    State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, Department of Biochemistry, College of Life Sciences, Sun Yat Sen Zhongshan University, 135 Xingangxi Road, 510275 Guangzhou, People s Republic of China
    Arch Toxicol 83:925-32. 2009
    ..Whole cell patch-clamp study on adult rat dorsal root ganglion neurons indicated that lt3a could enhance tetrodotoxin-sensitive sodium currents. This is a previously unknown function of M-superfamily conotoxins.
  79. ncbi Intra-organismal distribution of tetrodotoxin in two species of blue-ringed octopuses (Hapalochlaena fasciata and H. lunulata)
    Becky L Williams
    Department of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720 3140, USA
    Toxicon 54:345-53. 2009
    ..The distribution of tetrodotoxin (TTX) in previously unexamined tissues of two species of blue-ringed octopuses, wild-caught Hapalochlaena ..
  80. ncbi Development and single laboratory validation of an optical biosensor assay for tetrodotoxin detection as a tool to combat emerging risks in European seafood
    Katrina Campbell
    Institute for Global Food Security, School of Biological Sciences, Queen s University, David Keir Building, Stranmillis Road, Belfast, BT9 5AG, UK
    Anal Bioanal Chem 405:7753-63. 2013
    b>Tetrodotoxin (TTX) is a potent neurotoxin emerging in European waters due to increasing ocean temperatures...
  81. ncbi Bilateral and unilateral hippocampal inactivation did not differ in their effect on consolidation processes in the Morris water maze
    Jose M Cimadevilla
    Department of Neuroscience, University of Almeria, Almeria, Spain
    Int J Neurosci 118:619-26. 2008
    ..Wistar rats were trained in the Morris water maze during 4 consecutive days. Subjects received saline or tetrodotoxin in the dorsal hippocampus 1 min after training...
  82. ncbi Transfer profile of intramuscularly administered tetrodotoxin to artificial hybrid specimens of pufferfish, Takifugu rubripes and Takifugu niphobles
    Junjie Wang
    Graduate School of Science and Technology, Nagasaki University, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Toxicon 58:565-9. 2011
    b>Tetrodotoxin (TTX) was intramuscularly administered to artificially hybridized specimens of the pufferfish Takifugu rubripes and Takifugu niphobles to investigate toxin accumulation in hybrids, and TTX transfer/accumulation profiles in ..
  83. ncbi Synthesis of tetrodotoxin, a classic but still fascinating natural product
    Toshio Nishikawa
    Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya, Japan
    Chem Rec 13:286-302. 2013
    b>Tetrodotoxin, a toxic principle of puffer fish intoxication, is one of the most famous marine natural products due to its densely functionalized structure and potent toxicity...
  84. pmc Development of rat CA1 neurones in acute versus organotypic slices: role of experience in synaptic morphology and activity
    Anna De Simoni
    Department of Physiology, University College London, UK
    J Physiol 550:135-47. 2003
    ..We conclude that, for the parameters studied, changes seem to be preprogrammed by 5 days and their subsequent development is largely independent of environment...
  85. ncbi An improved synthesis of (-)-5,11-dideoxytetrodotoxin
    Masaatsu Adachi
    Laboratory of Organic Chemistry, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464 8601, Japan
    J Org Chem 78:1699-705. 2013
    We describe an improved synthesis of (-)-5,11-dideoxytetrodotoxin from an enone, which was used for synthesis of tetrodotoxin and its analogues in this laboratory...
  86. ncbi Comparison of sample preparation methods, validation of an UPLC-MS/MS procedure for the quantification of tetrodotoxin present in marine gastropods and analysis of pufferfish
    Judith Kouassi Nzoughet
    Institute of Agri food and Land Use, School of Biological Sciences, Queen s University Belfast, Belfast BT9 5AG, UK
    Food Chem 136:1584-9. 2013
    b>Tetrodotoxin (TTX) is one of the most potent marine neurotoxins reported. The global distribution of this toxin is spreading with the European Atlantic coastline now being affected...
  87. pmc Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7) [corrected]
    James R Walker
    Department of Chemistry, Structural Biology, and Computer Science, Stanford University, Stanford, CA 94305 5080, USA
    Proc Natl Acad Sci U S A 109:18102-7. 2012
    ..interest for the development of antinociceptive agents, is blocked by low nanomolar concentrations of (-)-tetrodotoxin(TTX) but not (+)-saxitoxin (STX) and (+)-gonyautoxin-III (GTX-III)...
  88. pmc Isolation and structural determination of the first 8-epi-type tetrodotoxin analogs from the newt, Cynops ensicauda popei, and comparison of tetrodotoxin analogs profiles of this newt and the puffer fish, Fugu poecilonotus
    Yuta Kudo
    Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai 981 8555, Japan
    Mar Drugs 10:655-67. 2012
    Identification of new tetrodotoxin (TTX) analogs from TTX-possessing animals might provide insight into its biosynthesis and metabolism...
  89. ncbi Effects of carbamazepine and amitriptyline on tetrodotoxinresistant Na+ channels in immature rat trigeminal ganglion neurons
    Yun Kyung Hur
    Department of Oral Medicine, School of Dentistry, Kyungpook National University, Daegu 700 412, Korea
    Arch Pharm Res 31:178-82. 2008
    ..Here we report the effects of carbamazepine (CBZ) and amitriptyline (ATL) on tetrodotoxin-resistant (TTX-R) Na' channels expressed on immature rat TG neurons...
  90. ncbi Effects of prostaglandin D2 on tetrodotoxin-resistant Na+ currents in DRG neurons of adult rat
    Andrea Ebersberger
    Department of Physiology I, Neurophysiology, University Hospital of Jena, Jena, Germany
    Pain 152:1114-26. 2011
    b>Tetrodotoxin-resistant (TTX-R) Na(+) channels play a key role in the generation of action potentials in nociceptive dorsal root ganglion (DRG) neurons and are an important target for the proinflammatory mediator prostaglandin E(2), which ..
  91. ncbi State-dependent calcium signaling in dendritic spines of striatal medium spiny neurons
    Adam G Carter
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 44:483-93. 2004
    ..By altering the sources, amplitude, and kinetics of spine Ca signals, state transitions may gate synaptic plasticity and gene expression in MSNs...
  92. pmc Tetrodotoxin-resistant sodium channels contribute to directional responses in starburst amacrine cells
    Nicholas W Oesch
    Neuroscience Graduate Program, Oregon Health and Sciences University, Portland, Oregon, United States of America
    PLoS ONE 5:e12447. 2010
    ..However, selective block of tetrodotoxin-resistant sodium channels did reduce the strength of the directional excitatory signal in the SBACs...
  93. ncbi Chronic blockade of glutamate receptors enhances presynaptic release and downregulates the interaction between synaptophysin-synaptobrevin-vesicle-associated membrane protein 2
    A Bacci
    Consiglio Nazionale delle Ricerche, Cellular and Molecular Pharmacology and B. Ceccarelli Centers, Department of Medical Pharmacology, University of Milan, 20129 Milan, Italy
    J Neurosci 21:6588-96. 2001
    ..They also suggest that one of the mechanisms through which this downregulation is achieved is an increased interaction of synaptophysin with synaptobrevin-VAMP2...
  94. ncbi Substance P-mediated modulation of pacemaker properties in the mammalian respiratory network
    Fernando Pena
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 24:7549-56. 2004
    ..This finding may have clinical implications for Rett syndrome in which SP levels along with other neuromodulators are decreased in the brainstem...
  95. ncbi Persistent sodium current and Na+/H+ exchange contributes to the augmentation of the reverse Na+/Ca2+ exchange during hypoxia or acute ischemia in ventricular myocytes
    Qiong Tang
    Cardio Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei, China
    Pflugers Arch 463:513-22. 2012
    ..In conclusion, during hypoxia or acute ischemia, both increased I (Na.P) and NHE contribute to the HIR- or AIR-I (NCX) with the former playing a major role comparing with the latter...
  96. pmc Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses
    Jimok Kim
    Departments of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 13:592-600. 2010
    ..This regulatory mechanism, mediated by activity-dependent changes in tonic endocannabinoid level, permits selective local tuning of inhibitory synapses in hippocampal networks...
  97. ncbi Activation of a capacitative Ca(2+) entry pathway by store depletion in cultured hippocampal neurones
    A Bouron
    Department of Pharmacology, University of Bern, Friedbuehlstrasse 49, Bern, Switzerland
    FEBS Lett 470:269-72. 2000
    ..Taken together, these experiments indicate that stores depletion can activate a capacitative Ca(2+) entry pathway in cultured hippocampal neurones and further demonstrate the existence of such a Ca(2+) entry in excitable cells...
  98. ncbi Isolation and characterization of a T-superfamily conotoxin from Conus litteratus with targeting tetrodotoxin-sensitive sodium channels
    Junliang Liu
    State Key Laboratory of Biocontrol, The Open Laboratory for Marine Functional Genomics of the State High Tech Development Program, Department of Biochemistry, College of Life Sciences, Sun Yat Sen Zhongshan University, People s Republic of China
    Peptides 28:2313-9. 2007
    ..8778). Under whole cell patch-clamp mode, lt5d inhibits tetrodotoxin-sensitive sodium currents on adult rat dorsal root ganglion neurons, but has no effects on tetrodotoxin-..
  99. ncbi Effects of pre-emptive drug treatment on astrocyte activation in the cuneate nucleus following rat median nerve injury
    Jiann Jy Chen
    Department of Medical Research, Tao Yuan General Hospital, Taoyuan, Taiwan
    Pain 148:158-66. 2010
    ..glutamate N-methyl-d-aspartate (NMDA) receptor antagonist), clonidine (alpha(2)-adrenoreceptor agonist), tetrodotoxin (TTX, sodium channel blocker) or lidocaine (local anesthetic) 30 min prior to median nerve CCI...
  100. ncbi Activity-dependent regulation of inhibitory synaptic transmission in hippocampal neurons
    Kenichi N Hartman
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Neurosci 9:642-9. 2006
    ..Notably, we found that the expression of GABAergic plasticity involves changes in the amount of neurotransmitter in individual vesicles...
  101. pmc Isoflurane inhibits the tetrodotoxin-resistant voltage-gated sodium channel Nav1.8
    Karl F Herold
    Department of Anesthesiology, Weill Cornell Medical College, New York, New York, USA
    Anesthesiology 111:591-9. 2009
    Voltage-gated sodium channels (Nav) mediate neuronal action potentials. Tetrodotoxin inhibits all Nav isoforms, but Nav1.8 and Nav1.9 are relatively tetrodotoxin-resistant (TTX-r) compared to other isoforms. Nav1...

Research Grants63

  1. Excitability of afferents evoking the exercise pressor reflex
    Victor Ruiz-Velasco; Fiscal Year: 2013
    ..Likewise, in muscles, whose arteries are narrowed by disease, exercise can cause excessive stimulation of the sensory nerves that reflexively activate the sympathetic nervous system muscle pain (i.e., claudication). ..
  2. SERT KO rats are a model of sex specific visceral pain
    James J Galligan; Fiscal Year: 2013
    ..is proposed to be due to interactions between 5-HT and estrogen on sensory neurons that lead to upregulation of tetrodotoxin-resistant sodium channels...
  3. NOVEL MECHANISMS OF OXYTOCIN ACTION
    Sarah K England; Fiscal Year: 2013
    ..generating an inward Na+ current that is Na+-dependent and insensitive to the voltage-gated Na+ channel blocker tetrodotoxin. Recently, a sodium leak channel (NALCN;Na+ leak channel, non-selective) with similar properties was identified ..
  4. Reversal of pain by group II metabotropic glutamate receptors
    Steve Davidson; Fiscal Year: 2013
    ..Two candidate currents, the tetrodotoxin- resistant Na+ and T-type Ca2+ current will be tested for their ability to be modulated by group II mGluRs in ..
  5. A Photo-triggered on-demand drug delivery system for chronic pain
    BRIAN PAUL TIMKO; Fiscal Year: 2012
    ..we will examine both the "on" and "off" state permeability of the membrane to a number of compounds, including tetrodotoxin (TTX), saxitoxin (STX), bupivacaine, and dexamethasone...
  6. CA IN MYELIN PRODUCING CELLS
    Ken McCarthy; Fiscal Year: 1993
    ..Treatments to be examined will include a blocker of neuronal activity (tetrodotoxin), a blocker of L-type calcium channels (nitrendipine), non-selective blockers of calcium channels (EGTA, Mg++), ..
  7. Molecular Determinants of Resurgent Sodium Currents in Sensory Neurons
    ANDREW DUANE PIEKARZ; Fiscal Year: 2010
    ..b>Tetrodotoxin-sensitive (TTX-S) VGSCs have the ability to influence the excitable properties of neurons through subthreshold ..
  8. Connectivity of Afferent Neurons in the Zebrafish Posterior Lateral Line
    Eliot R Dow; Fiscal Year: 2012
    ..to form synapses with hair cells of a single polarity will be tested by inhibiting action potentials with tetrodotoxin. Second, by comparing the transcriptomes of anteriorly and posteriorly polarized hair cells, the hypothesis ..
  9. WATER AND ELECTROLYTE TRANSPORT BY THE INTESTINE
    KENNETH HUBEL; Fiscal Year: 1990
    ..by determining whether the short-circuit current change induced by the peptide is reduced with the neurotoxin, tetrodotoxin. If it is, we will try to identify the transmitter with specific antagonists, e.g...
  10. CIRCADIAN REGULATION OF VASOPRESSIN GENE EXPRESSION
    Joseph Majzoub; Fiscal Year: 1993
    ..This will include assessment of the effects of treatment with cyclic nucleotides, low calcium and tetrodotoxin. Second, to determine whether the rhythm in SCN VP poly (A) tail length is dependent upon synthesis of the VP ..
  11. AFFERENT MECHANISMS UNDERLYING BLADDER PAIN
    WILLIAM DEGROAT; Fiscal Year: 2009
    ..2) Acute sensitization of bladder nociceptors involves a change in several membrane ion channels including: tetrodotoxin-resistant Na+ channels, yanilloid receptors (VRl) which are sensitive to capsaicin, ATP-sensitive purinergic ..
  12. LEUKOTRIENE SUBSTANCE P INTERACTIONS IN THE AIRWAYS
    EUNICE BLOOMQUIST; Fiscal Year: 1993
    ..LTD4 produces release of SP and SK through separate mechanisms; LTD4 induced SP release is inhibited by tetrodotoxin (TTX) a blocker of Na+ action potentials, while LTD4 induced SK release is unaffected by TTX...
  13. Sodium Channel Contratoxins Derived from Cone Snail Venoms
    Grzegorz Bulaj; Fiscal Year: 2007
    ..Archetypal examples in this regard are the alkaloids tetrodotoxin (TTX) and saxitoxin (SIX), both potent paralytic agents that act by binding to the same site on, and blocking ..
  14. MOLECULAR PHYSIOLOGY OF HYPERKALEMIC PERIODIC PARALYSIS
    Lawrence Hayward; Fiscal Year: 2001
    ..Whole-cell Na currents will be measured from MM14 muscle cells transfected with tetrodotoxin-resistant versions of wild-type or mutant Na channel cDNAs to assess muscle-specific influences upon Na channel ..
  15. INCREASED ACTION POTENTIAL DURATION & CARDIAC INOTROPHY
    David Lathrop; Fiscal Year: 1990
    ..and by veratridine and ATX II, which have been demonstrated to increase the time during which an inward, tetrodotoxin-sensitive, sodium current occurs during the action potential...
  16. MOLECULAR PHARMACOLOGY OF VOLTAGE SENSITIVE NA CHANNELS
    Edward Moczydlowski; Fiscal Year: 2001
    ..they are the target of several classes of drugs and neurotoxins such as local anesthetics, antiarrhythmics, tetrodotoxin and saxitoxin...
  17. MOLECULAR STUDIES OF SODIUM CHANNELS IN SKELETAL MUSCLE
    Basil Darras; Fiscal Year: 1993
    ..antibodies raised against unique portions of the alpha subunit peptides; 3) to determine the molecular basis of tetrodotoxin (TTX)-sensitivity and -insensitivity utilizing sodium channel mRNA analysis in TTX-sensitive adult muscle and ..
  18. CITRIC ACID CYCLE METABOLISM DURING CARDIAC SURGERY
    Michael Jessen; Fiscal Year: 2001
    ..based cardioplegic solution, 3) low sodium and low potassium cardioplegia, 4) potassium cardioplegia with tetrodotoxin added to achieve polarized arrest, 5) the potassium channel opener pinacidil to achieve hyperpolarized arrest, ..
  19. INTERACTION OF ISCHEMIA, DRUGS, AND RATE ON CONDUCTION
    Wayne Cascio; Fiscal Year: 1991
    ..conduction slowing induced by the Type 1 antiarrhythmic drugs (lidocaine, procainamide, flecainide) and Tetrodotoxin. These aims will be attained by utilizing standard microelectrode techniques to determine Vmax, conduction ..
  20. AVERMECTIN, TETRODOTOXIN, & RADICAL-ALDEHYDE CYCLIZATION
    Bert Fraser Reid; Fiscal Year: 1991
    ..A major new undertaking in Section H is the synthesis of tetrodotoxin. This substance displays unique biological activity in that it is specific for the identification and use of ..
  21. Na Channels in Afferents after Bladder Obstruction
    William Steers; Fiscal Year: 2006
    ..8 isoform. This Na alpha subunit gives rise to tetrodotoxin resistant (TTX-R) sodium (Na) currents in C-fiber afferents...
  22. CHEMISTRY AND BIOCHEMISTRY OF AQUATIC TOXINS
    Yuzuru Shimizu; Fiscal Year: 1999
    ..brevetoxins and okadaic acid derivatives; 4) blue-green algal toxins such as cyanoginosins and aphanorphin; 5) tetrodotoxin and its derivatives will be investigated...
  23. ALCOHOL AND MESOLIMBIC DOPAMINE PATHWAY
    QINGSHAN YAN; Fiscal Year: 2000
    ..DA release in the NACC will be compared with and without the++ treatments with: 1) perfusion with tetrodotoxin (TTX) or Ca -free medium into the NACC, both of which are known to interrupt membrane depolarization; 2) ..
  24. DORSAL ROOT GANGLION AS SOURCE OF NEUROPATHIC PAIN
    Thomas Baumann; Fiscal Year: 2001
    ..Furthermore, we will examine the dependence of spontaneous action potential discharge on the contribution of tetrodotoxin-sensitive and tetrodotoxin-resistant voltage-gated sodium currents...
  25. Molecular Physiology of Voltage-gated Ion Channels
    Richard Horn; Fiscal Year: 2009
    ..Cationic blockers will include extracellular toxins (tetrodotoxin, saxitoxin, and mu-conotoxin) and intracellular local anesthetics...
  26. BIOCHEMISTRY OF EXCITABLE MEMBRANES
    BRUCE KRUEGER; Fiscal Year: 1991
    ..The voltage dependence of block by saxitoxin (STX) and tetrodotoxin will be investigated in reconstituted vesicles using binding of 3H-STX...
  27. INHIBITORY MECHANISMS OF THE PANCREAS
    Haile Debas; Fiscal Year: 1990
    ..animal and in the isolated, vascularly perfused rat pancreas but not in dispersed isolated acini; and secondly, tetrodotoxin, which blocks axonal transmission, abolishes this inhibitory action of somaostatin...
  28. Molecular probing for the mechanism of neuropathic pain
    Ichiro Nishimura; Fiscal Year: 2006
    ..that constitutive changes occur in primary sensory neurons leading to abnormal peripheral accumulation of the tetrodotoxin-resistant sodium channel Nav1...
  29. MOLECULAR PHARMACOLOGY OF CARDIAC ION CHANNELS
    Ronald Li; Fiscal Year: 2003
    ..anesthetic block and slow inactivation gating processes, and mapped the crucial determinants for high-affinity tetrodotoxin block in the outer pore...
  30. CONTROL OF ENZYME LEVELS IN SKELETAL MUSCLE CELLS
    John Lawrence; Fiscal Year: 1990
    ..so that the effects of activity may be investigated by comparing active cells to cells paralyzed with tetrodotoxin. Using this strategy, we have shown that muscle activity leads to an increase in phosphorylase degradation and ..
  31. MOLECULAR EFFECTS OF EARLY EXPERIENCE ON MOTOR NEURON
    Robert Kalb; Fiscal Year: 1991
    ..test the contribution of the components of the motor unit to development using a-bungarotoxin, colchicine and tetrodotoxin. EM studies will correlate ultrastructural events in synaptogenesis with Cat- 301 expression and critical ..
  32. ENZYMOLOGY OF SINGLE NA-CHANNELS IN ARTIFICIAL BILAYERS
    Edward Moczydlowski; Fiscal Year: 1992
    ..2) Analysis of the molecular basis for binding of guanidinium toxins such as saxitoxin and tetrodotoxin to a specific receptor site on various Na-channel subtypes...
  33. Neural Bases of Drug Context-induced Cocaine Seeking
    RITA FUCHS LOKENSGARD; Fiscal Year: 2009
    ..VH), subiculum, and entorhinal cortex, in contextual reinstatement of cocaine and food seeking using the tetrodotoxin-induced reversible neural inactivation method...
  34. ACTIVITY AND NEUROTROPHIN EFFECTS ON SPINAL SYNAPSES
    TIMOTHY COPE; Fiscal Year: 2003
    ..the effect of muscle activity on synaptic strength, will be tested by paralyzing a peripheral muscle using tetrodotoxin applied to its efferent nerve, then stimulating to activate the muscle...
  35. FUNCTIONALLY RELATED ENZYMATIC CHANGES IN ADULT CNS
    Margaret Wong Riley; Fiscal Year: 1980
    ..Finally, we wish to know to what extent are these enzymatic alterations impulse dependent. We will introduce tetrodotoxin intravitreally to block afferent impulses to the geniculate, without blocking axoplasmic transport...
  36. Epileptogenic Mechanisms in Developmental Malformations
    KIMBERLE JACOBS; Fiscal Year: 2005
    ..Applying tetrodotoxin in an Elvax polymer to the cortical surface prior to onset will test this idea...
  37. Ionic mechanisms of TNFalpha-induced sensitization
    Maria Elena Morales; Fiscal Year: 2009
    ..Recent work has demonstrated TNF? modulation of the tetrodotoxin-resistant Na+ channel a subunit, Nav1.8...
  38. Neural blockade with vanilloids
    Igor Kissin; Fiscal Year: 2007
    ..inactivation phase of the local effect of RTX on nerves is primarily dependent on abolition of voltage-gated, tetrodotoxin-resistant (TTX-R) sodium currents...
  39. PLASTICITY IN DIAPHRAGM NEUROMOTOR CONTROL
    Gary Sieck; Fiscal Year: 2007
    ..In contrast, when DIAm paralysis is induced by unilateral tetrodotoxin (TTX) nerve blockade, susceptibility to neuromuscular transmission failure dramatically increases, and there ..
  40. INFLAMMATORY MEDIATOR-INDUCED NOCICEPTOR SENSITIZATION
    Michael Gold; Fiscal Year: 2001
    ..Using a model for the nociceptor terminal in vitro, it has been demonstrated that HIM's modulate a tetrodotoxin resistant voltage-gated Na current (TTX-R Ina) in a manner consistent with nociceptor sensitization...
  41. Functional Constraints on Vertebrate Voltage-Gated Sodium Channel Pore Structure
    CHARLES HANIFIN; Fiscal Year: 2009
    ..b>Tetrodotoxin resistance of salamander tissues will be characterized using simple electrophysiology as well as whole-cell ..
  42. TRANSMEMBRANE POTENTIAL MAPPING OF DEFIBRILLATION
    STEPHEN KNISLEY; Fiscal Year: 2002
    ..The maximum dV/dt of action potentials measured with microelectrodes and the sodium channel modulators, tetrodotoxin and high potassium, will be used to study transmembrane voltage-dependent fast inward sodium channel recovery ..
  43. ROLES OF NEUROTROPHINS IN OCULAR DOMINANCE PLASTICITY
    Takuji Kasamatsu; Fiscal Year: 2002
    ..effects of NT infusion will be studied in relation to an unusual level of binocular interactions between the tetrodotoxin-injected eye and the lid-sutured fellow eye...
  44. IMPACT OF SYNAPTIC BOMBARDMENT ON NEOCORTICAL NEURONS
    Mircea Steriade; Fiscal Year: 2001
    ..synaptic activity will be quantified from intracellular recordings obtained before and after microperfusion of tetrodotoxin or synaptic blockers...
  45. PULMONARY C-NEURON HYPERSENSITIVITY:CELLULAR MECHANISMS
    Lu Yuan Lee; Fiscal Year: 2005
    ..by activating the cyclic AMP/protein kinase A signaling pathway that leads to modulation of the function of tetrodotoxin-resistant sodium channel...
  46. MECHANISMS UNDERLYING MONOCULAR DEPRIVATION
    BARBARA GORDON LICKEY; Fiscal Year: 1999
    ..between NMDA receptor composition, physiology, and visual plasticity, we will use dark rearing, intraocular tetrodotoxin and drug treatment (MK-801) to perturb the plastic period and/or receptor development...
  47. Modulation of SNS Sodium Channel by Phosphorylation
    Jay Yang; Fiscal Year: 2005
    The recently discovered tetrodotoxin (TTX)-resistant and sensory neuron specific SNS (alternatively called the PN3 or NaV1.8) voltage gated sodium channel plays a critical role in neuropathic pain...
  48. SPECIFICITY OF GBg SIGNALING
    Diomedes Logothetis; Fiscal Year: 2004
    ..Gbg targets include, ion channels, (e.g. K+ (or GIRK) channels, neuronal type Ca2+ channels and the tetrodotoxin-insensitive Na+ channels), enzymes (e.g. PLA2, PLCb isoforms, adenylyl cyclase isoforms) and kinases (e.g...
  49. NAN SODIUM CHANNEL: NOVEL TARGET FOR PAIN DRUG DISCOVERY
    MATTHEW GONDA; Fiscal Year: 2000
    ..neurons, the majority of which are nociceptive, express sodium currents that are sensitive to the neurotoxin tetrodotoxin (TTX-S) and others that are resistant (TTX-R)...
  50. INDUCTIVE INTERACTIONS OF MOTONEURON AND MUSCLE
    MOTOY KUNO; Fiscal Year: 1980
    ..When impulse conduction along the sensory nerve is chronically blocked with tetrodotoxin, the efficiency of synaptic transmission at motoneurons from the disused sensory fibers was found to be ..
  51. IONIC CURRENTS OF ISOLATED SPINAL NEURONS
    James Buchanan; Fiscal Year: 1993
    ..acid receptors in the lamprey nervous system, and 4) determine whether N-methyl-D-aspartate (NMDA)-induced, tetrodotoxin-resistant membrane potential oscillations can occur in isolated neurons and determine the nature of their ..
  52. SYNTHETIC STUDIES ON COMPLEX NATURAL PRODUCTS
    Yoshito Kishi; Fiscal Year: 2003
    ..immobilized tetrodotoxin; 6. total synthesis of batrachotoxin, aranotin, and YW3699...
  53. NaN Sodium Channel:Novel Target for Pain Drug Discovery
    MATTHEW GONDA; Fiscal Year: 2003
    ..neurons, the majority of which are nociceptive, express sodium currents that are sensitive to the neurotoxin tetrodotoxin (TTX-S) and others that are resistant (TTX-R)...
  54. REGULATION OF GLUTAMATE RECEPTORS IN INDIVIDUAL SYNAPSES
    Guosong Liu; Fiscal Year: 2002
    ..desensitization, and calcium permeability are altered when network activity is changed by exposure to tetrodotoxin and NMDA-receptor blockers...
  55. ALCOHOL AND MESOLIMBIC DOPAMINE PATHWAY
    QINGSHAN YAN; Fiscal Year: 2002
    ..DA release in the NACC will be compared with and without the++ treatments with: 1) perfusion with tetrodotoxin (TTX) or Ca -free medium into the NACC, both of which are known to interrupt membrane depolarization; 2) ..
  56. RNAi-medicated inhibition of BDNF expression and alcohol-drinking behavior
    QINGSHAN YAN; Fiscal Year: 2008
    ..abstract_text> ..
  57. Neurophysiology and Biomechanics of Urethra in Stress Urinary Incontinence
    Naoki Yoshimura; Fiscal Year: 2008
    ..This is recognized as a high priority in the urologic/gynecologic care of SUI patients. [unreadable] [unreadable]..
  58. AFFERENT PLASTICITY UNDERLYING URETHRAL AND PELVIC PAIN
    Naoki Yoshimura; Fiscal Year: 2010
    ..This is recognized as a high priority in the urologic care of patients with IC/CPPS. ..
  59. Bladder Pain Gene Therapy with Pro-opiomelanocortin cDNA
    Naoki Yoshimura; Fiscal Year: 2004
    ..This research project is important to provide a solid basis for potential future clinical application. ..
  60. Afferent modulation in bladde dysfunction
    Naoki Yoshimura; Fiscal Year: 2007
    ..abstract not provided ..
  61. Lower urinary tract dysfunction in Parkinson's disease
    Naoki Yoshimura; Fiscal Year: 2003
    ..This is a high priority in the urologic care of patients with Parkinson's disease. ..
  62. METABOLIC ORGANIZATION & REGULATION IN THE VISUAL CORTEX
    Margaret Wong Riley; Fiscal Year: 2002
    ..Results from these studies are expected to provide insight into the molecular basis of metabolic responses of visual cortical neurons to changing functional demands. ..
  63. Neurochemical Organization of Brain Stem Respiratory Nuclei
    MARGARET TT WONG RILEY; Fiscal Year: 2010
    ....