prazosin

Summary

Summary: A selective adrenergic alpha-1 antagonist used in the treatment of heart failure, hypertension, pheochromocytoma, Raynaud's syndrome, prostatic hypertrophy, and urinary retention.

Top Publications

  1. ncbi Effects of modafinil and prazosin on cognitive and physiological functions in healthy volunteers
    S E Winder-Rhodes
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Psychopharmacol 24:1649-57. 2010
  2. pmc Dopamine receptor D3 regulates endocytic sorting by a Prazosin-sensitive interaction with the coatomer COPI
    Xin Zhang
    Dana Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 109:12485-90. 2012
  3. ncbi Doxazosin and terazosin suppress prostate growth by inducing apoptosis: clinical significance
    Natasha Kyprianou
    Division of Urology, Department of Surgery, University of Kentucky Medical Center, Lexington, USA
    J Urol 169:1520-5. 2003
  4. pmc Effects of prazosin, an α1-adrenergic receptor antagonist, on the seeking and intake of alcohol and sucrose in alcohol-preferring (P) rats
    Terril L Verplaetse
    Department of Psychology, Indiana University, Indianapolis, USA
    Alcohol Clin Exp Res 36:881-6. 2012
  5. ncbi Mutational analysis of the alpha 1a-adrenergic receptor binding pocket of antagonists by radioligand binding assay
    Maruf Ahmed
    Pharmacy Department, University of Rajshahi, Rajshahi 6205, Bangladesh
    Biol Pharm Bull 31:598-601. 2008
  6. pmc Placebo-controlled comparison of prazosin and cognitive-behavioral treatments for sleep disturbances in US Military Veterans
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Psychosom Res 72:89-96. 2012
  7. pmc Alpha1-adrenoceptor subtypes involved in vasoconstrictor responses to exogenous and neurally released noradrenaline in rat femoral resistance arteries
    Joseph Zacharia
    Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow G4 0BA, UK
    Br J Pharmacol 141:915-24. 2004
  8. pmc Effect of prazosin and guanfacine on stress-induced reinstatement of alcohol and food seeking in rats
    A D Le
    Neurobiology of Alcohol Laboratory, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON M5S 2S1, Canada
    Psychopharmacology (Berl) 218:89-99. 2011
  9. ncbi Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin
    Dierk Thomas
    Department of Cardiology, Medical University Hospital Heidelberg, Bergheimerstrasse 58, 69115, Heidelberg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 369:462-72. 2004
  10. ncbi Allosteric interactions between the antagonist prazosin and amiloride analogs at the human alpha(1A)-adrenergic receptor
    R A Leppik
    National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
    Mol Pharmacol 57:436-45. 2000

Detail Information

Publications232 found, 100 shown here

  1. ncbi Effects of modafinil and prazosin on cognitive and physiological functions in healthy volunteers
    S E Winder-Rhodes
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Psychopharmacol 24:1649-57. 2010
    ..placebo-controlled study, 12 healthy male adults received modafinil (300 mg), the α1-adrenoceptor antagonist prazosin (3 mg), both together and placebo on separate occasions at least 5 days apart...
  2. pmc Dopamine receptor D3 regulates endocytic sorting by a Prazosin-sensitive interaction with the coatomer COPI
    Xin Zhang
    Dana Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 109:12485-90. 2012
    ..We found that the antihypertensive drug Prazosin inhibits endocytic sorting by an off-target perturbation of the G protein-coupled receptor dopamine receptor D(3) ..
  3. ncbi Doxazosin and terazosin suppress prostate growth by inducing apoptosis: clinical significance
    Natasha Kyprianou
    Division of Urology, Department of Surgery, University of Kentucky Medical Center, Lexington, USA
    J Urol 169:1520-5. 2003
    ..This action alone however does not fully account for the long-term clinical responses exerted by these drugs in the treatment of patients with benign prostatic hyperplasia (BPH)...
  4. pmc Effects of prazosin, an α1-adrenergic receptor antagonist, on the seeking and intake of alcohol and sucrose in alcohol-preferring (P) rats
    Terril L Verplaetse
    Department of Psychology, Indiana University, Indianapolis, USA
    Alcohol Clin Exp Res 36:881-6. 2012
    Previous studies show that prazosin, an α(1) -adrenergic receptor antagonist, decreases alcohol drinking in animal models of alcohol use and dependence [Rasmussen et al. (2009) Alcohol Clin Exp Res 3:264-272; Walker et al...
  5. ncbi Mutational analysis of the alpha 1a-adrenergic receptor binding pocket of antagonists by radioligand binding assay
    Maruf Ahmed
    Pharmacy Department, University of Rajshahi, Rajshahi 6205, Bangladesh
    Biol Pharm Bull 31:598-601. 2008
    ..acids Asp106 in the third transmembrane domain (TMD), Gln167 in TMD IV of alpha 1a-AR were directly involved in prazosin, tamsulosin and KMD-3213 binding. The Asp106Ala mutant did not exhibit any affinity for [3H]prazosin...
  6. pmc Placebo-controlled comparison of prazosin and cognitive-behavioral treatments for sleep disturbances in US Military Veterans
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Psychosom Res 72:89-96. 2012
    ..This randomized controlled trial compared the effects of prazosin vs...
  7. pmc Alpha1-adrenoceptor subtypes involved in vasoconstrictor responses to exogenous and neurally released noradrenaline in rat femoral resistance arteries
    Joseph Zacharia
    Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow G4 0BA, UK
    Br J Pharmacol 141:915-24. 2004
    ..in rat femoral resistance arteries were characterised using a small vessel myograph, with antagonists prazosin (nonsubtype selective), 5-methyl-urapidil (alpha(1A)-selective), BMY 7378 (alpha(1D)-selective) and the ..
  8. pmc Effect of prazosin and guanfacine on stress-induced reinstatement of alcohol and food seeking in rats
    A D Le
    Neurobiology of Alcohol Laboratory, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON M5S 2S1, Canada
    Psychopharmacology (Berl) 218:89-99. 2011
    ..Here, we further addressed this issue by studying the effect of the alpha-1 adrenoceptor antagonist prazosin and the alpha-2 adrenoceptor agonist guanfacine on yohimbine-induced reinstatement.
  9. ncbi Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin
    Dierk Thomas
    Department of Cardiology, Medical University Hospital Heidelberg, Bergheimerstrasse 58, 69115, Heidelberg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 369:462-72. 2004
    ..To assess the action of the effects of prazosin, doxazosin, and terazosin on HERG currents, we investigated their acute electrophysiological effects on cloned ..
  10. ncbi Allosteric interactions between the antagonist prazosin and amiloride analogs at the human alpha(1A)-adrenergic receptor
    R A Leppik
    National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
    Mol Pharmacol 57:436-45. 2000
    ..The six amilorides examined strongly increased the dissociation rate of the antagonist [(3)H]prazosin from the alpha(1A)-adrenergic receptor in a concentration-dependent manner...
  11. ncbi A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder
    Murray A Raskind
    Veterans Affairs Northwest Network Mental Illness Research, Education and Clinical Center MIRECC, University of Washington, Seattle, Washington, USA
    Biol Psychiatry 61:928-34. 2007
    ..b>Prazosin, a brain active alpha-1 adrenergic receptor antagonist, significantly reduced trauma nightmares and sleep ..
  12. pmc Identification of alpha 1L-adrenoceptor in mice and its abolition by alpha 1A-adrenoceptor gene knockout
    I Muramatsu
    Division of Pharmacology, Department of Biochemistry and Bioinformative Sciences, University of Fukui School of Medicine, Eiheiji, Fukui, Japan
    Br J Pharmacol 155:1224-34. 2008
    ..The purpose of this was to identify alpha(1L)-adrenoceptors in mice and to examine their relationship to classical alpha(1)-adrenoceptors...
  13. ncbi The effect of breast cancer resistance protein and P-glycoprotein on the brain penetration of flavopiridol, imatinib mesylate (Gleevec), prazosin, and 2-methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic acid (PF-407288) in mice
    Lin Zhou
    Pfizer Inc, Eastern Point Road, MS 8118W 131, Groton, CT 06340, USA
    Drug Metab Dispos 37:946-55. 2009
    ..Four drugs, flavopiridol, imatinib mesylate (Gleevec), PF-407288, and prazosin, with different transport specificity for BCRP/Bcrp and MDR1/Mdr1a were selected, and the drug levels in plasma, ..
  14. pmc Efficacy and safety of scorpion antivenom plus prazosin compared with prazosin alone for venomous scorpion (Mesobuthus tamulus) sting: randomised open label clinical trial
    Himmatrao Saluba Bawaskar
    Bawaskar Hospital and Research Centre, Mahad, Dist Raigad, Maharashtra, India 402301
    BMJ 342:c7136. 2011
    ..for the benefit of scorpion antivenom and its efficacy compared with that of commonly used vasodilators, such as prazosin, is scarce...
  15. ncbi Asp125 and Thr130 in transmembrane domain 3 are major sites of alpha1b-adrenergic receptor antagonist binding
    Kazuya Takahashi
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Aoba, Niigata, Japan
    Biol Pharm Bull 30:1891-4. 2007
    Site-directed mutagenesis was used to investigate the molecular interactions involved in prazosin binding to the human alpha(1b)-adrenergic receptor (alpha(1b)-AR) receptor...
  16. ncbi Prazosin administered prior to inescapable stressor blocks subsequent exaggeration of acoustic startle response in rats
    Sean T Manion
    Neuroscience Program, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Pharmacol Biochem Behav 86:559-65. 2007
    ..The present study used this animal model to investigate the effects of prazosin, an alpha(1) adrenoceptor antagonist, on stress-induced elevation of acoustic startle response (ASR)...
  17. pmc The alpha1-adrenergic receptor antagonist, prazosin, reduces alcohol drinking in alcohol-preferring (P) rats
    Dennis D Rasmussen
    VISN 20 Mental Illness Research Education and Clinical Center, Mental Health Service, Department of Veterans Affairs Medical Center and University of Washington, Seattle, Washington, USA
    Alcohol Clin Exp Res 33:264-72. 2009
    ..Accordingly, we tested the hypothesis that blockade of alpha(1)-adrenergic receptors will suppress alcohol drinking in rats selectively bred for alcohol preference (P line)...
  18. pmc Combining naltrexone and prazosin in a single oral medication decreases alcohol drinking more effectively than does either drug alone
    Janice C Froehlich
    Indiana University School of Medicine, Indianapolis, Indiana
    Alcohol Clin Exp Res 37:1763-70. 2013
    ..Given that NTX and prazosin can each reduce alcohol drinking in rats selectively bred for alcohol preference and high voluntary alcohol ..
  19. ncbi Prazosin treatment of nightmares related to posttraumatic stress disorder
    Matthew R Dierks
    School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, IN, USA
    Ann Pharmacother 41:1013-7. 2007
    To describe current data evaluating the use of prazosin in adults with posttraumatic stress disorder (PTSD) who are experiencing nightmares.
  20. pmc Alpha-1D adrenoceptors are involved in reserpine-induced supersensitivity of rat tail artery
    Naoyuki Taki
    Department of Pharmacology, School of Medicine, Fukui Medical University, Matsuoka, Fukui 910 1193, Japan
    Br J Pharmacol 142:647-56. 2004
    ..b>Prazosin, a subtype-nonselective antagonist, blocked the responses to phenylephrine with the same potency, regardless of ..
  21. ncbi Enduring vulnerability to transient reinstatement of hemiplegia by prazosin after traumatic brain injury
    D L Stibick
    Department of Psychology, University of New Mexico, Albuquerque 87131, USA
    J Neurotrauma 18:303-12. 2001
    ..This study used a within-subject, dose-response design to determine whether prazosin (PRAZ), an alpha1-NA antagonist, or propranolol (PROP), a beta-NA antagonist, would continue to reinstate ..
  22. ncbi Modulatory role of a constitutively active population of alpha(1D)-adrenoceptors in conductance arteries
    Khalid Ziani
    Departamento de Farmacologia, Facultad de Farmacia, Universitat de Valencia, 46100 Burjassot, Valencia, Spain
    Am J Physiol Heart Circ Physiol 282:H475-81. 2002
    ..in resting tone (IRT) that evidences it was observed only in iliac and proximal mesenteric and was inhibited by prazosin (pIC(50) = 9.57), 5-methylurapidil (pIC(50) = 7.61), and BMY 7378 (pIC(50) = 8.77)...
  23. ncbi Phe-308 and Phe-312 in transmembrane domain 7 are major sites of alpha 1-adrenergic receptor antagonist binding. Imidazoline agonists bind like antagonists
    D J Waugh
    Department of Molecular Cardiology NB5, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    J Biol Chem 276:25366-71. 2001
    ..of either Phe-308 or Phe-312 resulted in significant losses of affinity (4-1200-fold) for the antagonists prazosin, WB4101, BMY7378, (+) niguldipine, and 5-methylurapidil, with no changes in affinity for phenethylamine-type ..
  24. ncbi Differential antagonism by conotoxin rho-TIA of contractions mediated by distinct alpha1-adrenoceptor subtypes in rat vas deferens, spleen and aorta
    Vanessa Lima
    Department of Pharmacology, Instituto de Biociencias, UNESP, Botucatu, SP 18618 000, Brazil
    Eur J Pharmacol 508:183-92. 2005
    ..It is concluded that rho-TIA will be useful for distinguishing the role of particular alpha1-adrenoceptor subtypes in native tissues...
  25. ncbi The alpha(1A)-adrenoceptor subtype mediates contraction in rat femoral resistance arteries
    Y P Jarajapu
    Vascular Assessment Group, School of Biological and Biomedical Sciences, Glasgow Caledonian University, Cowcaddens Road, Glasgow G4 0BA, Scotland, UK
    Eur J Pharmacol 422:127-35. 2001
    ..b>Prazosin, 5-methyl-urapidil and 2-([2,6-dimethoxyphenoxyethyl]aminomethyl)-1,4-benzodioxane (WB 4101) produced rightward ..
  26. pmc Prazosin effects on stress- and cue-induced craving and stress response in alcohol-dependent individuals: preliminary findings
    Helen C Fox
    The Connecticut Mental Health Center, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Alcohol Clin Exp Res 36:351-60. 2012
    ..Here we report findings from a preliminary efficacy study of the alpha-1 receptor antagonist, prazosin, in modulating these relapse-relevant factors in alcohol-dependent individuals.
  27. ncbi Long-term administration of prazosin improves bladder storage function: results from a study in spontaneously hypertensive rats
    Nobuhiro Haga
    Department of Urology, Fukushima Medical University School of Medicine, Fukushima, Japan
    Int J Urol 18:785-91. 2011
    To investigate the effects of long-term administration of the α(1) -adrenoceptor antagonist prazosin on afferent inputs from the lower urinary tract (LUT).
  28. pmc Prazosin reduces alcohol drinking throughout prolonged treatment and blocks the initiation of drinking in rats selectively bred for high alcohol intake
    Janice C Froehlich
    Indiana University School of Medicine, Indianapolis, Indiana
    Alcohol Clin Exp Res 37:1552-60. 2013
    This study examined whether prazosin reduces alcohol drinking over the course of prolonged treatment and whether it blocks the initiation of alcohol drinking in rats with a genetic predisposition toward high alcohol drinking, that is ..
  29. ncbi Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study
    Murray A Raskind
    Northwest Network VISN 20 Mental Illness Research, Eduation, and Clinical Center, VA Puget Sound Healthcare System, Seattle, USA
    Am J Psychiatry 160:371-3. 2003
    b>Prazosin is a centrally active alpha(1) adrenergic antagonist. The authors' goal was to evaluate prazosin efficacy for nightmares, sleep disturbance, and overall posttraumatic stress disorder (PTSD) in combat veterans.
  30. pmc Regional heterogeneity of α-adrenoreceptor subtypes in arteriolar networks of mouse skeletal muscle
    Alex W Moore
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    J Physiol 588:4261-74. 2010
    ..Phenylephrine (PE; α1AR agonist) evoked greater (P < 0.05) constriction in 3A (inhibited by 10(-8) m prazosin; α1AR antagonist) while UK 14304 (UK; α2AR agonist) evoked greater (P < 0...
  31. pmc In vitro alpha1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel alpha1A-adrenoceptor selective antagonists
    T J Williams
    New Leads Discovery, Center for Biological Research, Neurobiology Unit, Roche Bioscience, Palo Alto, California 94304, USA
    Br J Pharmacol 127:252-8. 1999
    ..Ro 70-0004 (aka RS-100975) and a structurally-related compound RS-100329, and compares them with those of prazosin and tamsulosin...
  32. ncbi Lateralization and catecholaminergic neuroimmunomodulation: prazosin, an alpha1/alpha2-adrenergic receptor antagonist, suppresses interleukin-1 and increases interleukin-10 production induced by lipopolysaccharides
    Jing Dong
    Neurobiologie Intégrative U394, Institut Francois Magendie, Bordeaux, France
    Neuroimmunomodulation 10:163-8. 2002
    ....
  33. ncbi Prazosin versus quetiapine for nighttime posttraumatic stress disorder symptoms in veterans: an assessment of long-term comparative effectiveness and safety
    Melanie G Byers
    Southern Arizona VA Health Care System, Tucson, AZ, USA
    J Clin Psychopharmacol 30:225-9. 2010
    ..Nighttime symptoms are often unrelieved by selective serotonin reuptake inhibitor therapy, and increased use of prazosin or quetiapine for treatment is seen...
  34. pmc Treatment of nightmares with prazosin: a systematic review
    Simon Kung
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 87:890-900. 2012
    ..We performed a systematic review to evaluate the evidence for the use of prazosin in the treatment of nightmares...
  35. pmc Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression
    Lucy Y Wang
    VA Northwest Network Mental Illness Research, Education, and Clinical Center MIRECC, Seattle, WA 98115, USA
    Am J Geriatr Psychiatry 17:744-51. 2009
    ..b>Prazosin, a nonsedating generic medication used for hypertension and benign prostatic hypertrophy, antagonizes NE effects ..
  36. ncbi Management of scorpion sting: prazosin or dobutamine
    B D Gupta
    Department of Pediatrics, Umaid Hospital for Women and Children, Regional Institute of Maternal and Child Health, Dr Sampurnanand Medical College, Jodhpur, India
    J Trop Pediatr 56:115-8. 2010
    To compare the efficacy of Dobutamine and Prazosin in the management of cases with scorpion sting.
  37. pmc The alpha1A-adrenoceptor gene is required for the alpha1L-adrenoceptor-mediated response in isolated preparations of the mouse prostate
    Kt Gray
    Prostate Research Co operative, Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
    Br J Pharmacol 155:103-9. 2008
    ..Responses of mouse prostate to noradrenaline are known to be mediated by alpha1L-adrenoceptors, which are thought to be a functional phenotype of alpha1A-adrenoceptor...
  38. pmc Haemodynamic effects of dicentrine, a novel alpha 1-adrenoceptor antagonist: comparison with prazosin in spontaneously hypertensive and normotensive Wistar-Kyoto rats
    S M Yu
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei
    Br J Pharmacol 106:797-801. 1992
    ..an aporphine derivative isolated from the plant Lindera megaphylla, were investigated and compared with prazosin in rats. 2. In anaesthetized normotensive Wistar-Kyoto (WKY) rats, i.v. administration of dicentrine (0.1, 0.5, 1...
  39. ncbi Role of prazosin on cardiovascular manifestations and pulmonary edema following severe scorpion stings in Saudi Arabia
    Abdulrahman K Al-Asmari
    Department of Research Center and Medicine, Riyadh Military Hospital, Riyadh 11159, Kingdom of Saudi Arabia
    Saudi Med J 29:299-302. 2008
    We report the ameliorating effects of prazosin on the cardiovascular CV manifestations and pulmonary edema PE after treatment with antivenom AV failed to improve the conditions of scorpion stung patients...
  40. ncbi Tracing the flow of knowledge: geographic variability in the diffusion of prazosin use for the treatment of posttraumatic stress disorder nationally in the Department of Veterans Affairs
    Ilan Harpaz-Rotem
    Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA
    Arch Gen Psychiatry 66:417-21. 2009
    ..Preliminary evidence has emerged about the effectiveness of the alpha(1)-adrenergic blocker prazosin hydrochloride in the treatment of nightmares and hyperarousal among patients with posttraumatic stress disorder (..
  41. ncbi Prazosin treatment of trauma nightmares and sleep disturbance in soldiers deployed in Iraq
    Jess Calohan
    Madigan Army Medical Center and VA Northwest Network Mental Illness, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    J Trauma Stress 23:645-8. 2010
    Trauma nightmares and sleep disturbance impair combat soldiers' functioning. The alpha-1 adrenoreceptor antagonist prazosin has been demonstrated effective for these symptoms in Vietnam veterans...
  42. ncbi Prazosin treatment in the management of scorpion envenomation
    Erdal Peker
    Department of Pediatrics, Yuzuncu Yil University School of Medicine, Van, Turkey
    Hum Exp Toxicol 29:231-3. 2010
    ..Alpha receptor stimulation plays important role in the pathogenesis of pulmonary edema. Prazosin, a post synaptic alpha blocker, can be recommended as an effective drug in the treatment of serious scorpion ..
  43. ncbi Prazosin for treatment of nightmares related to posttraumatic stress disorder
    Heather R Taylor
    Walgreens Pharmacy, Selma, AL, USA
    Am J Health Syst Pharm 65:716-22. 2008
    The efficacy of prazosin for the treatment of posttraumatic stress disorder (PTSD)-related nightmares is reviewed.
  44. pmc Gender-modulated endogenous baseline neuropeptide Y Y1-receptor activation in the hindlimb of Sprague-Dawley rats
    Dwayne N Jackson
    Neurovascular Research Laboratory, School of Kinesiology, University of Western Ontario, London, Ontario, Canada N6A 3K7
    J Physiol 562:285-94. 2005
    ..vascular conductance was measured during infusion of BIBP3226 (Y(1)-receptor antagonist; 100 microg kg(-1)), prazosin (alpha(1)-receptor antagonist; 20 microg kg(-1)), and combined blockade...
  45. ncbi Influence of hypertension on lower urinary tract symptoms in benign prostatic hyperplasia
    Kimio Sugaya
    Department of Urology, Faculty of Medicine, University of the Ryukyus, Uehara, Nishihara, Okinawa, Japan
    Int J Urol 10:569-74; discussion 575. 2003
    ..To clarify the influence of hypertension on lower urinary tract symptoms (LUTS) we examined the relationship between blood pressure, LUTS, and the effect of terazosin on LUTS in patients with benign prostatic hyperplasia (BPH)...
  46. ncbi Differences in the effects of alpha-1 adrenergic blockade with prazosin and indoramin on coronary blood flow during exercise
    R J Bache
    Department of Medicine, University of Minnesota Medical School, Minneapolis
    J Pharmacol Exp Ther 245:232-7. 1988
    This study compared the effects of two selective alpha-1 adrenergic blockers, prazosin and indoramin, on the response of coronary blood flow and myocardial oxygen consumption during treadmill exercise in chronically instrumented dogs...
  47. ncbi Y1- and alpha1-receptor control of basal hindlimb vascular tone
    Dwayne N Jackson
    Neurovascular Research Laboratory, School of Kinesiology, Rm 3110, Thames Hall, Univ of Western Ontario, London, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 287:R228-33. 2004
    ..volume infusion of N(2)-(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-d-arginine amide (BIBP3226; 100 microg/kg), prazosin (20 microg/kg), and combined blockade to the left hindlimb. Vascular conductance increased 1.5 +/- 0.5 microl...
  48. ncbi Prazosin for the treatment of posttraumatic stress disorder sleep disturbances
    Lisa J Miller
    Department of Pharmacy, Michael E DeBakey Veterans Administration Medical Center, Houston, Texas, USA
    Pharmacotherapy 28:656-66. 2008
    ..Stimulation of these receptors may contribute to PTSD-related trauma-content nightmares. Prazosin, a highly lipophilic alpha(1)-adrenergic receptor blocker that is traditionally used to treat hypertension and ..
  49. pmc Angiotensin II is a critical mediator of prazosin-induced angiogenesis in skeletal muscle
    Matthew C Petersen
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Microcirculation 14:583-91. 2007
    ..The purpose of this study was to determine whether a high-salt diet modulates physiological angiogenesis in skeletal muscle by altering angiotensin II (ANGII) and vascular endothelial growth factor (VEGF) levels...
  50. ncbi Combined administration of alpha1-adrenoceptor antagonist prazosin and beta-blocker propranolol impairs spatial avoidance learning on a dry arena
    Tomas Petrasek
    Institute of Physiology AS CR, vvi, Prague, Czech Republic
    Behav Brain Res 208:402-7. 2010
    ..aimed at studying the effects of separate or combined systemic administration of the alpha1-adrenergic antagonist prazosin (1 and 2 mg/kg) and beta-blocker propranolol (5 and 20 mg/kg) on the hippocampus-dependent learning in the active ..
  51. pmc Effects of prazosin, clonidine, and propranolol on the elevations in brain reward thresholds and somatic signs associated with nicotine withdrawal in rats
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, University of Florida, 100 S Newell Dr, P O Box 100256, Gainesville, FL 32610, USA
    Psychopharmacology (Berl) 212:485-99. 2010
    ..Increased noradrenergic transmission has been reported to play an important role in opioid withdrawal, but little is known about the role of noradrenergic transmission in nicotine withdrawal...
  52. ncbi Individual differences in the effects of chronic prazosin hydrochloride treatment on hippocampal mineralocorticoid and glucocorticoid receptors
    Mohamed Kabbaj
    Biomedical Sciences Department, College of Medicine and Neurosciences, Florida State University, Tallahassee, FL, USA
    Eur J Neurosci 25:3312-8. 2007
    ..alpha(1) antagonist (1-[4-amino-6,7-dimethoxy-2-quinazolinyl]-4-[2-furanylcarbonyl] piperazine) hydrochloride (prazosin) (0.5 mg/kg, i.p...
  53. ncbi Prazosin, an alpha-1 adrenergic antagonist, reduces cocaine-induced reinstatement of drug-seeking
    Xiang Yang Zhang
    Division of Substance Abuse, Yale University School of Medicine, West Haven, Connecticut 06516, USA
    Biol Psychiatry 57:1202-4. 2005
    Norepinephrine is implicated in cocaine's behavioral effects. In this study, we tested the effect of prazosin, an alpha1-adrenergic receptor antagonist, on cocaine-induced reinstatement of drug-seeking behavior.
  54. ncbi Dexmedetomidine enhances the local anesthetic action of lidocaine via an alpha-2A adrenoceptor
    Tatsushi Yoshitomi
    Department of Dental Anesthesiology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Anesth Analg 107:96-101. 2008
    ..Thus, we evaluated the effect of dexmedetomidine and other alpha-2 adrenoceptor agonists on the local anesthetic action of lidocaine at the periphery and explored the mechanism involved...
  55. ncbi A pilot trial of the alpha-1 adrenergic antagonist, prazosin, for alcohol dependence
    Tracy L Simpson
    Center of Excellence in Substance Abuse Treatment and Education, University of Washington, Seattle, WA 98108, USA
    Alcohol Clin Exp Res 33:255-63. 2009
    ..Theory and preclinical evidence suggest that noradrenergic circuits may be involved in alcohol reinforcement and relapse. We therefore tested the alpha-1 adrenergic receptor antagonist, prazosin, as a pharmacotherapy for AD.
  56. ncbi Daytime prazosin reduces psychological distress to trauma specific cues in civilian trauma posttraumatic stress disorder
    Fletcher B Taylor
    Rainier Associates, Tacoma, Washington 98467, USA
    Biol Psychiatry 59:577-81. 2006
    ..trauma-related nightmares improve or resolve with bedtime administration of the alpha-1 adrenergic antagonist prazosin often continue to experience PTSD symptoms during the day...
  57. ncbi Utility of scorpion antivenin vs prazosin in the management of severe Mesobuthus tamulus (Indian red scorpion) envenoming at rural setting
    H S Bawaskar
    Bawaskar Hospital and Research Center, Mahad, Dist Raigad Maharashtra, India 402 301
    J Assoc Physicians India 55:14-21. 2007
    ..Since 1983 the advent of prazosin revolutionized the management of severe scorpion sting...
  58. ncbi Anti-angiogenic effects and mechanism of prazosin
    Chun Hou Liao
    Department of Surgery, Fu Jen Catholic University, Taipei, Taiwan
    Prostate 71:976-84. 2011
    Alpha1-adrenoceptors antagonists (doxazosin, terazosin, prazosin) are commonly prescribed for benign prostate hyperplasia and hypertension...
  59. ncbi Pumpkin seed oil and phytosterol-F can block testosterone/prazosin-induced prostate growth in rats
    Yuh Shyan Tsai
    Institute of Clinical Medicine, Department of Urology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Urol Int 77:269-74. 2006
    This study was undertaken to investigate the effects of pumpkin seed oil alone or combined with Phytosterol-F on testosterone/prazosin-induced (T-P) prostate growth in rats.
  60. ncbi Efficacy of anti-scorpion venom serum over prazosin in the management of severe scorpion envenomation
    V S Natu
    Vijayashree Hospital, Umroli, Chiplun, India corrected
    J Postgrad Med 56:275-80. 2010
    Scorpion venoms cause a massive release of neurotransmitters. Either anti-scorpion venom serum (AScVS) or prazosin has been used in the management of severe scorpion envenomation.
  61. ncbi Influence of prazosin and clonidine on morphine analgesia, tolerance and withdrawal in mice
    Umit Kazim Ozdogan
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Itainen Pitkakatu 4, FIN 20520 Turku, Finland
    Eur J Pharmacol 460:127-34. 2003
    ..We examined the effects of clonidine (alpha(2)-adrenoceptor agonist) and prazosin (alpha(1)-adrenoceptor antagonist) on morphine analgesia, tolerance and withdrawal...
  62. ncbi Basal forebrain cholinergic immunolesion by 192IgG-saporin: evidence for a presynaptic location of subpopulations of alpha 2- and beta-adrenergic as well as 5-HT2A receptors on cortical cholinergic terminals
    M Heider
    Paul Flechsig Institute for Brain Research, University Leipzig, Germany
    Neurochem Res 22:957-66. 1997
    ..The lesion-induced receptor changes suggest that the alterations in cortical 5-HT2 receptor binding observed in patients with Alzheimer's disease might be secondary to cholinergic deficits...
  63. ncbi Identification of binding sites of prazosin, tamsulosin and KMD-3213 with alpha(1)-adrenergic receptor subtypes by molecular modeling
    Masaji Ishiguro
    Suntory Institute for Bioorganic Research, 1 1 1 Wakayamadai, Shimahon cho, Mishima gun, Osaka, Japan
    Life Sci 71:2531-41. 2002
    ..The alpha(1)-antagonists used in this study were prazosin, tamsulosin and KMD-3213...
  64. ncbi Pre- and post-training infusion of prazosin into the bed nucleus of the stria terminalis impaired acquisition and retention in a Morris water maze task
    Hsiu Chen Chen
    Department of Psychology, National Taiwan University, Taipei, Taiwan, ROC
    Chin J Physiol 47:49-59. 2004
    ..Groups of rats received intra-BNST infusion of vehicle, norepinephrine, prazosin or both drugs shortly before or after each daily training session, or shortly before retention tests...
  65. ncbi Enhanced arteriolar alpha-adrenergic constriction impairs dilator responses and skeletal muscle perfusion in obese Zucker rats
    Jefferson C Frisbee
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    J Appl Physiol (1985) 97:764-72. 2004
    ..were challenged with dilator stimuli under control conditions and after blockade of alpha-adrenoreceptors with prazosin, phentolamine, or yohimbine...
  66. ncbi Endothelial NOS is main mediator for shear stress-dependent angiogenesis in skeletal muscle after prazosin administration
    Oliver Baum
    Department of Anatomy and Physiology, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Königin Luise Str 15, D 14195 Berlin Dahlem, Germany
    Am J Physiol Heart Circ Physiol 287:H2300-8. 2004
    ..increase of wall shear stress in capillaries by oral administration of the alpha1-adrenergic receptor antagonist prazosin induces angiogenesis in skeletal muscles...
  67. ncbi Prazosin: a pharmacological antidote for scorpion envenomation
    V Gupta
    J Trop Pediatr 52:150-1. 2006
  68. ncbi Suppression of human prostate cancer cell growth by alpha1-adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis
    N Kyprianou
    Department of Biochemistry and Molecular Biology, and University of Maryland Cancer Center, University of Maryland School of Medicine, Baltimore 21201, USA
    Cancer Res 60:4550-5. 2000
    ..This evidence provides the rationale for targeting both drugs, already in clinical use and with established adverse-effect profiles, against prostatic tumors for the treatment of advanced prostate cancer...
  69. pmc Prazosin effects on objective sleep measures and clinical symptoms in civilian trauma posttraumatic stress disorder: a placebo-controlled study
    Fletcher B Taylor
    Northwest Network VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Biol Psychiatry 63:629-32. 2008
    b>Prazosin, a central nervous system (CNS) active alpha-1 adrenoreceptor antagonist, has reduced nightmares and sleep disturbance in placebo-controlled studies of combat-related posttraumatic stress disorder (PTSD)...
  70. pmc Prazosin displays anticancer activity against human prostate cancers: targeting DNA and cell cycle
    Ssu Chia Lin
    School of Pharmacy, National Taiwan University, Taipei, Taiwan
    Neoplasia 9:830-9. 2007
    ..However, there are few studies elucidating the effect of prazosin. In this study, prazosin displayed antiproliferative activity superior to that of other alpha1-blockers, ..
  71. ncbi Differences in the subcellular localization of alpha1-adrenoceptor subtypes can affect the subtype selectivity of drugs in a study with the fluorescent ligand BODIPY FL-prazosin
    Tatsuo Sugawara
    Department of Molecular, Cell Pharmacology, National Children s Medical Research Center, Tokyo, Japan
    Life Sci 70:2113-24. 2002
    ..In the present study, we used flow cytometry analysis with the fluorescent ligand, BODIPY FL-prazosin, to study the relationship between the subcellular distribution of subtype receptors and the subtype-selective ..
  72. ncbi The alpha1-adrenergic antagonist prazosin improves sleep and nightmares in civilian trauma posttraumatic stress disorder
    Fletcher Taylor
    Rainier Associates, Tacoma, WA 98467, USA
    J Clin Psychopharmacol 22:82-5. 2002
    ..b>Prazosin is an alpha1-adrenoceptor antagonist commonly used as an antihypertensive agent...
  73. ncbi Enhancer aided in vitro permeation of atenolol and prazosin hydrochloride through mice skin
    L H Reddy
    Department of Pharmaceutical Technology, V.L. College of Pharmacy, Raichur, India
    Indian J Exp Biol 39:47-51. 2001
    Effect of penetration enhancers were studied on the permeation of antihypertensive drugs prazosin hydrochloride and atenolol through full thickness skin of swiss albino mice...
  74. ncbi Prazosin reduces trauma-related nightmares in older men with chronic posttraumatic stress disorder
    Elaine R Peskind
    Department of Veterans Affairs Northwest Network Mental Illness Research, Education and Clinical Center, Seattle, Washington, USA
    J Geriatr Psychiatry Neurol 16:165-71. 2003
    ..PTSD secondary to military or Holocaust trauma were prescribed the lipophilic alpha-1 adrenergic antagonist prazosin for treatment-resistant trauma-related nightmares...
  75. ncbi Preparation and characterization of inclusion complexes of prazosin hydrochloride with beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin
    Longxiao Liu
    Zhejiang University, College of Pharmaceutical Science, Hangzhou 310027, People s Republic of China
    J Pharm Biomed Anal 40:122-7. 2006
    The slightly water-soluble drug prazosin hydrochloride (PRH) and its inclusion with either beta-cyclodextrin (betaCD) or hydroxypropyl-beta-cyclodextrin (HPbetaCD) were investigated...
  76. pmc Addition of a signal peptide sequence to the alpha1D-adrenoceptor gene increases the density of receptors, as determined by [3H]-prazosin binding in the membranes
    Ramona Petrovska
    Department of Pharmaceutical Biosciences, Unit of Pharmacology, Uppsala University, Box 591, BMC, Uppsala SE 751 24, Sweden
    Br J Pharmacol 144:651-9. 2005
    ..We show that the density of alpha1D-adrenoceptors, observed by [3H]-prazosin binding, gradually increased with longer truncations of the N-terminus...
  77. ncbi Clinical case series: the use of Prazosin for combat-related recurrent nightmares among Operation Iraqi Freedom combat veterans
    Christine Maura Daly
    Department of Psychiatry, Madigan Army Medical Center, Tacoma, WA 98431, USA
    Mil Med 170:513-5. 2005
    ..On the basis of reports that the brain-accessible alpha1-adrenergic antagonist Prazosin substantially reduced chronic combat-related nightmares among Vietnam War veterans, we evaluated Prazosin effects ..
  78. ncbi Prazosin reduces nightmares in combat veterans with posttraumatic stress disorder
    Murray A Raskind
    Northwest Network Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System and University of Washington, Seattle 98108, USA
    J Clin Psychiatry 63:565-8. 2002
    Preclinical and clinical observations suggest that the centrally active alpha1-adrenergic antagonist prazosin might alleviate trauma content nightmares and other symptoms in combat veterans with chronic posttraumatic stress disorder (PTSD)...
  79. ncbi Urodynamic effects of terazosin treatment for Japanese patients with symptomatic benign prostatic hyperplasia
    Yoshinori Tanaka
    Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Urol 167:2492-5. 2002
    ..terazosin hydrochloride daily has been routinely used in North America and Europe. We investigated the urodynamic effects of 2 mg. terazosin daily on Japanese patients with symptomatic BPH using pressure flow study...
  80. ncbi Combined terazosin and verapamil therapy in essential hypertension. Hemodynamic and pharmacokinetic interactions
    M L Lenz
    Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Am J Hypertens 8:133-45. 1995
    ..The orthostasis seen in some patients appears to be due to the combined vasodilatory effects rather than negative ionotropic or chronotropic effects...
  81. pmc Truncated isoforms inhibit [3H]prazosin binding and cellular trafficking of native human alpha1A-adrenoceptors
    F Coge
    Institut de Recherches Servier, Division de Pharmacologie Moleculaire et Cellulaire, 125 Chemin de Ronde, 78 290 Croissy sur Seine, France
    Biochem J 343:231-9. 1999
    ..The 7TMalpha(1A)-AR isoforms transiently expressed in COS-7 cells bound [(3)H]prazosin with high affinity (K(d) 0...
  82. ncbi Noradrenaline acting on alpha1-adrenoceptor mediates REM sleep deprivation-induced increased membrane potential in rat brain synaptosomes
    Gitanjali Das
    School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Neurochem Int 52:734-40. 2008
    ....
  83. ncbi Cocaine-induced hypophagia and hyperlocomotion in rats are attenuated by prazosin
    Paul Wellman
    Department of Psychology, Texas A and M University, College Station, TX 77843 4235, USA
    Eur J Pharmacol 455:117-26. 2002
    The present studies examined the effects of antagonizing alpha(1)-adrenoceptors via systemic administration of prazosin on the behavioral actions of cocaine in rats, including induction of locomotion and suppression of eating...
  84. ncbi The functional alpha-adrenoceptor in dog caudal vesical arteries is mainly an alpha1A subtype
    M Nakazawa
    Department of Pharmacology, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Auton Autacoid Pharmacol 22:253-9. 2002
    ..3 Prazosin at 0.01 microM and rauwolscine at 0.1 microM failed to affect the NA-induced vasoconstriction. Prazosin at 0...
  85. ncbi Effects of imipramine on the expression and development of morphine dependence in mice
    Mohammad Reza Zarrindast
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P O Box 13145 784, Tehran, Iran
    Eur J Pharmacol 473:19-25. 2003
    ..The alpha2-adrenoceptor antagonist, yohimbine (4 mg/kg), itself but not the alpha1-adrenoceptor antagonist, prazosin (1 mg/kg), increased jumping and decreased the imipramine effect...
  86. ncbi Immunohistochemical and functional evidence for a noradrenergic regulation in the horse penile deep dorsal vein
    P Recio
    Departamento de Fisiologia, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
    Int J Impot Res 16:486-91. 2004
    ..channel-blockers (guanethidine and tetrodotoxin, respectively) and of alpha1- and alpha2-adrenergic antagonists (prazosin and rauwolscine, respectively)...
  87. ncbi Effect of clonidine on colonic motility in rats
    Teruyasu Umezawa
    Department of Physiology, School of Medical Sciences, Showa University, Hatanodai 1 5 8, Shinagawa, Tokyo 142 8555, Japan
    Auton Neurosci 107:32-6. 2003
    ..by pre-administration of yohimbine, an alpha(2)-adrenoceptor antagonist, but not by pre-administration of prazosin, an alpha(1)-adrenoceptor antagonist...
  88. ncbi Potentiation by yohimbine of alpha-adrenoceptor-mediated vasoconstriction in response to clonidine in the rabbit ear vein
    Ding Zhao
    School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei, PR China
    Eur J Pharmacol 589:201-5. 2008
    ..94+/-11.18% and 88.78+/-11.54% of the maximum response to noradrenaline, respectively. Prazosin 0...
  89. pmc Tail arteries from chronically spinalized rats have potentiated responses to nerve stimulation in vitro
    Melanie Yeoh
    Prince of Wales Medical Research Institute, Randwick, NSW 2031, Australia
    J Physiol 556:545-55. 2004
    ..At both stages, the alpha-adrenoceptor antagonists prazosin (10 nm) and idazoxan (0.1 microm) produced less blockade of nerve-evoked contraction in spinalized arteries...
  90. ncbi Effect of the vascular endothelium on contractions induced by noradrenaline and phenylephrine in perforating branch of the human internal mammary artery
    Srdan Pesic
    Department of Pharmacology, Medical Faculty, 81 Braće Tasković, 18000 Nis, Yugoslavia
    Pol J Pharmacol 55:581-93. 2003
    ..The effects of selective alpha1-adrenoceptor antagonist, prazosin and selective alpha2-adrenoceptor antagonist, rauwolscine were concentration-dependent, and they induced a ..
  91. ncbi Norepinephrine activates extracellular-regulated kinase in cortical neurons
    Lara M Tolbert
    Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 54:983-93. 2003
    ..The influence of norepinephrine on the phosphorylation of extracellular-regulated protein kinase is characterized...
  92. ncbi Carvedilol blockade of rat myocardial alpha1-adrenoceptors
    Eirik Qvigstad
    Department of Pharmacology, University of Oslo, P O Box 1057 Blindern, N 0316 Oslo, Norway
    Eur J Pharmacol 481:83-9. 2003
    ..Thus, carvedilol antagonizes the myocardial alpha(1)-adrenoceptors with a 9-fold lower potency than the beta-adrenoceptors. Antagonism of myocardial alpha(1)-adrenoceptor evoked effects may contribute to clinical effects of carvedilol...
  93. ncbi Evidence that alpha(1B)-adrenoceptors are involved in noradrenaline-induced contractions of rat tail artery
    Sven Jähnichen
    Institute of Pharmacy, Free University of Berlin, Konigin Luise Str 2 4, Berlin 14195, Germany
    Eur J Pharmacol 488:157-67. 2004
    ..55) were antagonized in a competitive manner by prazosin (pK(B) 9.24), tamsulosin (pK(B) 8...
  94. ncbi Alpha-1 adrenoceptor agonists generate a "fast" NMDA receptor-independent motor rhythm in the neonatal rat spinal cord
    H Gabbay
    Dept of Anatomy and Cell Biology, The Hebrew University Medical School, P O Box 12272, Jerusalem 91120, Israel
    J Neurophysiol 92:997-1010. 2004
    ..The fast rhythm was blocked by 1 microM of the alpha1-adrenoceptor antagonist prazosin but not by 1-20 microM of the alpha2-adrenoceptor blocker yohimbine, it could be initiated and maintained by ..
  95. ncbi Activation of subfornical organ neurons in rats through pre- and postsynaptic alpha-adrenoceptors
    Eiko Honda
    Department of Biosciences, Kyushu Dental College, 2 6 1 Manazuru, Kokurakitaku, Kitakyushu 803 8580 Japan
    Am J Physiol Regul Integr Comp Physiol 290:R1646-53. 2006
    ..The phenylephrine-induced inward currents were inhibited by the alpha1-antagonist prazosin. The alpha2-agonist clonidine decreased the frequency of spontaneous GABAergic inhibitory postsynaptic currents (..
  96. ncbi Noradrenergic stimulation within midbrain raphe increases electrolyte excretion in rats
    P L Cedraz-Mercez
    Department of Physiological Sciences, Biology Institute, Federal Rural University of Rio de Janeiro, BR465, Km 7, 23890 000, Seropedica, RJ, Brazil
    Exp Physiol 92:923-31. 2007
    ..42 and 4.2 nmol in 0.2 microl) or the alpha(1)-adrenergic antagonist prazosin (PRZ, 0.24 and 2.4 nmol in 0.2 microl). (2) Intra-MRN microinjections of saline, IDZ (4.2 nmol in 0...
  97. ncbi Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat
    David Centurión
    Departamento de Farmacobiologia, Cinvestav Coapa, Czda de los Tenorios 235, Col Granjas Coapa, 14330 Mexico D F, Mexico
    Eur J Pharmacol 535:234-42. 2006
    ..The adrenoceptor antagonist properties of prazosin (alpha1) and yohimbine (alpha2) were also analysed for comparison...
  98. ncbi Alpha1L-adrenoceptors mediate contractions of the isolated mouse prostate
    Katherine T Gray
    Prostate Research Co operative, Victorian College of Pharmacy, Monash University, 381 Royal Parade, Parkville, Victoria, 3052, Australia
    Eur J Pharmacol 540:155-61. 2006
    ..Concentration-response curves to noradrenaline of the prostatic smooth muscle were antagonised by prazosin, N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-alpha, alpha-dimethyl-1H-indole-3-ethanamine (RS-17053), 2-(2,..
  99. ncbi Selective agonists reveal alpha(1A)- and alpha(1B)-adrenoceptor subtypes in caudal artery of the young rat
    J Pares-Hipolito
    Departamento de Farmacobiologia, Centro de Investigación y de Estudios Avanzados Sede Sur, Mexico, D F
    Auton Autacoid Pharmacol 26:371-8. 2006
    ..methanesulfonamide) or to phenylephrine and to prazosin (alpha(1)-adrenoceptor antagonist), or the selective alpha(1A)-adrenoceptor antagonists 5-methylurapidil, RS ..
  100. pmc Characterization of the postjunctional alpha 2C-adrenoceptor mediating vasoconstriction to UK14304 in porcine pulmonary veins
    T Görnemann
    Institut fur Pharmazie, Freie Universitat Berlin, Berlin, Germany
    Br J Pharmacol 151:186-94. 2007
    ..Therefore, we characterized the alpha(2)-adrenoceptor subtypes mediating contraction in isolated porcine pulmonary veins...
  101. ncbi Alpha1-adrenergic receptor stimulation induces the expression of receptor activator of nuclear factor kappaB ligand gene via protein kinase C and extracellular signal-regulated kinase pathways in MC3T3-E1 osteoblast-like cells
    Toshihiro Nishiura
    Section of Biochemistry, Department of Functional Bioscience, Fukuoka Dental College, 2 15 1 Tamura, Sawara ku, Fukuoka 814 0193, Japan
    Arch Oral Biol 52:778-85. 2007
    ..Osteoblastic cells have been demonstrated to express alpha(1)-adrenergic receptors...

Research Grants62

  1. Adolescent Alcohol,Dysregulated Stress System, and PTSD Vulnerability
    GERHARD H SCHULTEIS; Fiscal Year: 2013
    ..Specific Aim 3 will examine whether systemically active CRF (e.g. MPZP) and NE (e.g. prazosin) antagonists can reverse PTSD-like consequences in the social defeat trauma model refined in Aim 1, and any ..
  2. Does doxazosin attenuate stress-induced smoking and improve clinical outcomes?
    SHERRY ANN MCKEE; Fiscal Year: 2012
    ..preliminary data on stress reactivity in the laboratory with a selective alpha-1 adrenergic receptor antagonist, prazosin, supporting a role for alpha-1 adrenergic receptors in stress-induced tobacco relapse...
  3. Rodent Model of PTSD-like conditions-Role of Noradrenergic System
    SHANAZ MOHAMMEDALI TEJANI BUTT; Fiscal Year: 2010
    ..noradrenergic activity in the prefrontal cortex, amygdala and hippocampus;2) to evaluate whether treatments with prazosin or propranolol will differentially ameliorate the behavioral and neuroanatomical outcomes measured in Aim 1 in ..
  4. Center for Neuroregulation in Alcohol Dependence (CeNiAD)
    Andrew J Saxon; Fiscal Year: 2010
    ..CeNiAD) grew from the clinical observation that the CNS active generic CM adrenoreceptor (AR) antagonist prazosin reduced or eliminated alcohol drinking in veterans with posttraumatic stress disorder (PTSD) and comorbid alcohol ..
  5. Noradrenergic Agents As Potential New Pharmacotherapies for Alcohol Drinking
    Dennis D Rasmussen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Our recent studies suggest that prazosin - a safe, well-characterized, well-tolerated, orally active, inexpensive, FDA-approved 11-adrenergic receptor antagonist - may provide a much-needed ..
  6. Doxazosin an a1 Antagonist for Alcohol Dependence
    GEORGE ANTHONY KENNA; Fiscal Year: 2012
    ..a new pharmacological target for AD, recent studies have shown that the prototype a1 NE receptor antagonist prazosin reduces alcohol drinking in different animal models...
  7. Effect of Prazosin on Alcohol Craving, Stress Dysregulation and Alcohol Relapse
    Rajita Sinha; Fiscal Year: 2013
    ..double blind, placebo-controlled combined laboratory and clinical outcome study to test the efficacy of Prazosin (PZ) in decreasing alcohol craving, anxiety, stress dysregulation and alcohol use outcomes in treatment seeking ..
  8. Neural Mechanisms of Change During Alcohol Use DisorderTreatment with Prazosin
    CLAIRE WILCOX; Fiscal Year: 2013
    ..utilize fMRI and other measures to investigate the mechanisms of effect (and explore predictors of effect) of prazosin, an alpha 1 antagonist, on drinking...
  9. Mechanisms of Increased Ambulatory Blood Pressure in Intradialytic Hypertension
    Peter Noel Van Buren; Fiscal Year: 2013
    ..b>prazosin on ambulatory blood pressure, vascular resistance, and mediators of vascular resistance in patients with ..
  10. Clinical Trials of the Adrenergic a-1 Antagonist Prazosin for Alcohol Dependence
    Tracy L Simpson; Fiscal Year: 2012
    ..Neuropharmacology of alcohol and prazosin: Emerging pre-clinical evidence shows that noradrenergic systems are involved in brain processes relevant to AD, ..
  11. Stimulant Pharmacotherapy: Noradrenergic Targets
    THOMAS RICHARD KOSTEN; Fiscal Year: 2013
    ..2. To conduct two clinical trials of agents modulating NE activity through alpha 1-NE blockade (prazosin and carvedilol) or NE reduction by inhibiting dopamine beta hydroxylase (Proj 2 &3). 3...
  12. BAROREFLEX AND POSTERIOR HYPOTHALAMIC NEUROPEPTIDE-Y
    John Martin; Fiscal Year: 1991
    ..in sympathetic and/or parasympathetic nerve activity, the effect of pretreatment of animals with propranolol, prazosin, and/or methylatropine on the NPY- and CCH-induced changes in the cardiovascular system will be evaluated...
  13. NEUROCHEMICALS IN HYPOTHALAMIC SIGNALING AFTER COITUS
    K Y Pau; Fiscal Year: 2000
    ..NET) mRNAs occurs by 15-min postcoitus in locus coeruleus (LC), while intrahypothalamic infusion of either prazosin (alpha1 adrenergic blocker) or desipramine (NET blocker) alters the GnRH/LH surge. The P.I...
  14. Medication Development for Protracted Abstinence in Alcoholism
    Barbara J Mason; Fiscal Year: 2013
    ..Specific Aim 4-human) we have identified 5 drugs (aprepitant, levetiracetam, zonisamide, oxcarbazepine, prazosin) hypothesized to normalize the dysregulated brain systems related to the negative emotional states and craving ..
  15. Alzheimer's Disease Cooperative Study
    Paul S Aisen; Fiscal Year: 2013
    ..early results supporting an adrenergic approach amelioration of behavioral symptoms with a multicenter trial of prazosin. Aim 3: Design new instruments for use in clinical trials...
  16. MEDICAL THERAPY IN BENIGN PROSTATIC HYPERPLASIA
    Michael Lieber; Fiscal Year: 2001
    ..Both of these drugs as well as other alpha blockers, such as doxazosin and prazosin, now are being used widely in the United States and around the world, both by urologists and primary care ..
  17. Clinical Pharmacology of 3,4-Methylenedioxy Amphetamines
    John E Mendelson; Fiscal Year: 2010
    ..In Experiment 5 we will investigate the effect of the alpha-blocker prazosin on the response to MDMA. Alpha-blockers may attenuate MDMA actions in humans...
  18. SYSTEMIC AND LOCAL REGULATION OF MYOMETRIAL ACTIVITY
    Jorge Figueroa; Fiscal Year: 1993
    ..the effects of continuous local administration of oxytocin, phenylephrine and the alpha 1 adrenergic antagonist prazosin on: myometrial activity; uterine oxytocin responsiveness; and myometrial oxytocin and alpha adrenergic receptors...
  19. ALPHA-ADRENOCEPTOR SUBTYPE & CL CURRENT IN PAROTID ACINI
    CHARLES BOCKMAN; Fiscal Year: 2000
    ..of whole-cell Ca2+-dependent Cl- currents in the presence and absence of 5-methylurapidil, WB-4101, and prazosin will be used to determine the alpha1-AR subtype coupled to Cl- efflux and fluid secretion...
  20. COCAINE ABUSE & EXERCISE INDUCED HEATSTROKE
    PETER LOMAX; Fiscal Year: 1990
    ..Drugs which modify central adrenergic function (prazosin and clonidine) will be tested for their ability to prevent the onset of hyperthermia and to ameliorate ..
  21. ALPHA ADRENERGIC REGULATION OF THE VASCULAR NA+ PUMP
    Stephen Navran; Fiscal Year: 1992
    ..by monitoring ouabain-sensitive 86Rb uptake, 22Na influx and numbers of alpha 1 and alpha 2 receptors by (3H) prazosin and (3H) yohimbine binding...
  22. Methamphetamine Pharmacotherapy Development Center
    John Mendelson; Fiscal Year: 2009
    ..that we propose examining are the alpha-2 agonist clonidine, the beta-blocker carvedilol, the alpha-l antagonist prazosin, and the norepinephrine reuptake inhibitor atomoxetine...
  23. ALPHA 1-ADRENERGIC RECEPTORS & SMOOTH MUSCLE RESPONSES
    Robert Brown; Fiscal Year: 1992
    ..will be detergent solubilized from DDT-1 smooth muscle cells and purified using derivatives of the antagonist prazosin as ligands for affinity chromatography. Endogenous G proteins will also be identified and purified DDT-1 cells...
  24. ABNORMAL SODIUM CHANNEL REGULATION IN HUMAN HYPERTENSION
    JAMES BUBIEN; Fiscal Year: 2001
    ..Finally, the efficacy of amiloride, triamterene, prazosin, and terazosin on abnormal lymphocyte ASSCs will be evaluated...
  25. VASOPRESSIN & ALPHA-ADRENOCEPTORS--ELDERLY HYPERTENSION
    Haralambos Gavras; Fiscal Year: 1990
    ..by blood pressure responses to a V1 inhibitor) after salt loading or sympathetic inhibiton (by clonidine or prazosin) and to test the effect of salt-loading on alpha2-adrenoceptors of salt-sensitive and salt-resistant ..
  26. Psychostimulants and Alpha-1 Adrenoceptor Subtypes
    Paul Wellman; Fiscal Year: 2006
    ..These studies will advance our understanding of the behavioral functions of brain a l-AR subtypes and may lead to the identification of new drugs that inhibit eating without activating brain reinforcement systems. ..
  27. Prazosin for Noncombat Trauma PTSD
    Murray Raskind; Fiscal Year: 2008
    ..a double-blind placebo-controlled augmentation trial of the generically available alpha-1 adrenergic antagonist prazosin in chronic posttraumatic stress disorder (PTSD) caused by noncombat ("civilian") trauma...
  28. Psychopathology of Alzheimer's: APOE and the HPA Axis
    Murray Raskind; Fiscal Year: 2005
    ..Specific Aim 3. To determine the effect of CSF cortisol concentrations on cognitive decline and on incidence of mild cognitive impairment and probable AD among nondemented older persons with the APOE-E4 allele followed longitudinally. ..
  29. Heavy Metal and Drug Self-Administration: Mechanisms
    PAUL JEFFERSON WELLMAN; Fiscal Year: 2010
    ..e., lead contamination and cocaine use. Based on the available literature, there is reason to believe that environmental pollutants may increase vulnerability to drug addiction. ..
  30. Aging Effects on a-Adrenergic Activity in Female Bladder
    Natalia Dmitrieva; Fiscal Year: 2006
    ..The results of these studies will be the basis for developing a longer research program. ..
  31. Hyperthermia: Uncoupling the agony from Ecstasy
    JON SPRAGUE; Fiscal Year: 2007
    ..thyrotoxic [unreadable] crisis). [unreadable] [unreadable] [unreadable]..
  32. Vascular tone and blood pressure control during exercise
    John Buckwalter; Fiscal Year: 2005
    ..This is an issue of fundamental importance that may have important implications for individuals with peripheral vascular disease. ..
  33. Ecstasy's neurotoxicity: role of hyperthermia
    JON SPRAGUE; Fiscal Year: 2004
    ....
  34. EXTRAHYPOTHALAMIC AVP: SYNTHESIS AND SECRETION
    Adam Chodobski; Fiscal Year: 2002
    ..These studies will form the basis for development of pathological models and, consequently, effective therapies for the treatment of CNS disorders, such as trauma, SAH, and stroke. ..
  35. Cholinergic and GABAergic Mechanisms in the Septohippocampal Pathway
    Meenakshi Alreja; Fiscal Year: 2010
    ..The above hypothesis will be tested using electrophysiological, immunohistochemical and NO visualization techniques in rodent brain slices. ..
  36. Organic Nitrate Metabolism, Tolerance and Action
    Ho Leung Fung; Fiscal Year: 2010
    ..believe that our studies can provide new and meaningful data that will contribute to the establishment of a unifying mechanism for organic nitrate action and deleterious effects, and lead to their better therapeutic use ..
  37. NTS Adenosine Receptors in Cardiovascular Control
    DONAL S O apos LEARY; Fiscal Year: 2010
    ....
  38. CARDIOVASCULAR CONCOMITANTS OF ULTRASONIC VOCALIZATIONS
    Mark Blumberg; Fiscal Year: 2002
    ..Through these approaches, an integrated view of the varied mechanisms by which infant and adult mammals regulate cardiovascular function during physiological and behavioral challenges will emerge. ..
  39. ALCOHOL AND MESOLIMBIC DOPAMINE PATHWAY
    QINGSHAN YAN; Fiscal Year: 2002
    ..This will elucidate the relative contribution of 5-HT2 receptors to the regulation of ethanol-induced DA release and help to explain the effects of 5-HT2 antagonists on alcohol consumption reported in the literature. ..
  40. REGULATION OF CEREBRAL ARTERY DILATION
    Mark T Nelson; Fiscal Year: 2010
    ....
  41. Toxicokinetics and Toxicodynamics of GHB and Precursors
    Ho Leung Fung; Fiscal Year: 2004
    ..A pharmacogenetic mapping of the pharmacological effects of GHB will be obtained. The effects of tolerance development, withdrawal, gender, receptor blockade on these effects will be examined. ..
  42. GABA Medications for Tobacco Addiction
    Mehmet Sofuoglu; Fiscal Year: 2009
    ..The findings of this study will provide valuable information to develop new pharmacotherapies for smoking cessation. ..
  43. ALCOHOL EFFECTS ON OPIOMELANOCORTINERGIC REGULATION
    DENNIS RASMUSSEN; Fiscal Year: 2009
    ....
  44. Mechanisms of altered venous tone in hypertension
    ALEX PEREZ RIVERA; Fiscal Year: 2005
    ..Answers to these questions will provide a basic understanding of venous function that could lead to better pharmacological approaches not only for hypertension treatment but also for any disease in which there is a vein dysfunction. ..
  45. TNF Alters Renal Tubular Function in Diabetes
    Frank Gesek; Fiscal Year: 2005
    ..Complementary techniques are used to examine alterations in vivo and at the cellular level. Our studies provide insights into the earliest changes that occur in DT due to the cytokine TNF. ..
  46. AMPHETAMINE-LIKE STIMULANTS: NOREPINEPHRINE & BEHAVIOR
    CRAIG BERRIDGE; Fiscal Year: 2005
    ..Information obtained in these studies may provide insight into mechanisms subserving, and treatment of, stimulant drug abuse. ..
  47. Neurobiology of Orexin/Hypocretin-Induced Arousal
    CRAIG BERRIDGE; Fiscal Year: 2004
    ..These studies will provide a better understanding of the neurobiology of orexin, the neurobiology of sleep and waking, and the potential role of orexin in narcolepsy and other disorders of arousal. ..
  48. Dopamine Mechanisms and Receptors in Raphe 5-HT Neurons
    Samir Haj Dahmane; Fiscal Year: 2004
    ....
  49. Conference--Smooth Muscle
    Mark Nelson; Fiscal Year: 2003
    ..The extensive opportunities for informal interactions will allow investigators at all levels to meet new colleagues, explore new ideas and techniques, and develop new collaborations. ..
  50. IS NON-ADHERENCE A REVEALED PREFERENCE
    Leslie Lenert; Fiscal Year: 2003
    ..We will also use an expert panel to assess the clinical match between patients' regimens and their preferences. ..
  51. SYNTHESIS OF MDR REVERSING POLYENES
    MERRITT ANDRUS; Fiscal Year: 2003
    ..This is an important first step toward a molecular understanding of the unique recognition properties, transport mechanism of Pgp, and will further facilitate the design of new, more potent reversal agents. ..
  52. Toxicokinetics and Toxicodynamics of Nitrite Inhalants
    Ho Leung Fung; Fiscal Year: 2005
    ..We believe that our proposal represents novel approaches toward the understanding of nitrite inhalant toxicity in vivo. ..
  53. Antisense Antiviral Agent for West Nile Infections
    Patrick Iversen; Fiscal Year: 2005
    ..Aim 3: Investigate cellular drug transport, protein binding, and physical characteristics, as well as establish a formulation for future animal pharmacokinetic and toxicology studies. ..
  54. Mechanism of Disulfiram-Induced Cocaine Abstinence
    David Weinshenker; Fiscal Year: 2009
    ..abstract_text> ..
  55. Long-Term Neural Determinants of Cardiovascular Diseases
    John Osborn; Fiscal Year: 2009
    ..abstract_text> ..
  56. Novel Approaches for Burn Injury Cardiac Dysfunction
    Atsuko Yatani; Fiscal Year: 2009
    ..D. The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  57. NEUROCHEMISTRY OF AMPHETAMINE INDUCED AROUSAL
    CRAIG BERRIDGE; Fiscal Year: 2008
    ..Information obtained in these studies may provide insight into mechanisms underlying, and future treatment of, stimulant drug abuse, ADHD and narcolepsy. ..
  58. Vascular Structure and Function with Aging
    Brad Behnke; Fiscal Year: 2008
    ..No page numbering necessary. Not to exceed 3 publications; 2 for predoctoral candidates.) E Check if Appendix is included ..
  59. Regulation of the Endothelial Cell Glycocalyx
    Brian Duling; Fiscal Year: 2008
    ..The experiments offer the potential for understanding a new level of microvascular regulation, and for developing strategies to understand the intracellular signaling that leads to modification of the glycocalyx. ..
  60. Mechanisms of Peripheral Microvascular Disease
    David Stepp; Fiscal Year: 2008
    ..abstract_text> ..
  61. Mechanism of Ca2+ Sensitization in Smooth Muscle
    Toshio Kitazawa; Fiscal Year: 2006
    ..abstract_text> ..
  62. CORONARY ARTERY REGULATION BY CA2+SIGNALING & ESTROGEN
    Mark Nelson; Fiscal Year: 2003
    ..This work should also suggest novel mechanisms for therapeutic interventions to mimic the beneficial effects of estrogen and nitric oxide on calcium signaling in coronary arteries. ..