1 methyl 3 isobutylxanthine

Summary

Summary: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES

Top Publications

  1. ncbi Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins
    W C Yeh
    Tularik Inc, South San Francisco, California 94080
    Genes Dev 9:168-81. 1995
  2. ncbi In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP
    W Deng
    Center for Gene Therapy, Tulane University Health Sciences Center, SL-99, 1430 Tulane Avenue, New Orleans, Louisiana, 70112, USA
    Biochem Biophys Res Commun 282:148-52. 2001
  3. pmc A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell
    T C Rich
    Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 98:13049-54. 2001
  4. ncbi Fundamental significance of specific phosphodiesterases in the control of spontaneous meiotic resumption in porcine oocytes
    Martin F Laforest
    Centre de Recherche en Biologie de la Reproduction, Departement des Sciences Animales, Faculté des Sciences de l Agriculture et d Alimentation, Universite Laval, Ste Foy, Quebec, Canada G1K 7P4
    Mol Reprod Dev 70:361-72. 2005
  5. pmc Transcriptional regulation of adipogenesis by KLF4
    Kivanc Birsoy
    Laboratory of Molecular Genetics, Rockefeller University, New York, NY 10021, USA
    Cell Metab 7:339-47. 2008
  6. ncbi cAMP increases surface expression of NKCC2 in rat thick ascending limbs: role of VAMP
    Pablo A Ortiz
    Hypertension and Vascular Research Division, Dept of Internal Medicine, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202, USA
    Am J Physiol Renal Physiol 290:F608-16. 2006
  7. ncbi Electrophysiological characterization of rat and mouse olfactory receptor neurons from an intact epithelial preparation
    M Ma
    Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Neurosci Methods 92:31-40. 1999
  8. pmc Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation
    S D Munger
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 294:2172-5. 2001
  9. pmc Fast adaptation in mouse olfactory sensory neurons does not require the activity of phosphodiesterase
    Anna Boccaccio
    International School for Advanced Studies, S I S S A, Sector of Neurobiology, 34014 Trieste, Italy
    J Gen Physiol 128:171-84. 2006
  10. pmc Persistent activation of transducin by bleached rhodopsin in salamander rods
    H R Matthews
    Physiological Laboratory, University of Cambridge, United Kingdom
    J Gen Physiol 108:557-63. 1996

Research Grants

  1. Requirement for Glucocorticoids for Adipogenesis in vivo.
    Charles A Harris; Fiscal Year: 2012
  2. Cyclic GMP Phosphodiesterase in Signaling
    Hsien Yu Wang; Fiscal Year: 2007
  3. REGULATION OF GROWTH AND DIFFERENTIATION BY RETINOIDS
    Richard Niles; Fiscal Year: 1990
  4. RPE TRANSEPITHELIAL TRANSPORT
    DONALD FRAMBACH; Fiscal Year: 1992
  5. Neurotoxicant Disruption of Astroglial Differentiation
    Timothy Zacharewski; Fiscal Year: 2003
  6. INTERACTION OF CFTR AND EPITHELIAL NA CHANNELS
    Douglas Eaton; Fiscal Year: 2003
  7. TRANSMEMBRANE MOVEMENTS
    ALBERT ROOS; Fiscal Year: 1991
  8. Role of Regulated CIC CI Channels in CI Secretion in CF
    John Cuppoletti; Fiscal Year: 2006
  9. CHLORIDE CHANNELS AND GASTRIC ACID SECRETION
    John Cuppoletti; Fiscal Year: 2003
  10. CYCLIC AMP/ADENOSINE PATHWAY
    Edwin Jackson; Fiscal Year: 2002

Detail Information

Publications226 found, 100 shown here

  1. ncbi Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins
    W C Yeh
    Tularik Inc, South San Francisco, California 94080
    Genes Dev 9:168-81. 1995
    ....
  2. ncbi In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP
    W Deng
    Center for Gene Therapy, Tulane University Health Sciences Center, SL-99, 1430 Tulane Avenue, New Orleans, Louisiana, 70112, USA
    Biochem Biophys Res Commun 282:148-52. 2001
    ..The data suggested that the hMSCs may have been differentiated into early progenitors of neural cells in vitro under conditions that increase the intracellular level of cAMP...
  3. pmc A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell
    T C Rich
    Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 98:13049-54. 2001
    ..The decline in cAMP levels near the membrane was prevented by pretreatment with phosphodiesterase inhibitors. These data demonstrate that spatially and temporally distinct cAMP signals can coexist within simple cells...
  4. ncbi Fundamental significance of specific phosphodiesterases in the control of spontaneous meiotic resumption in porcine oocytes
    Martin F Laforest
    Centre de Recherche en Biologie de la Reproduction, Departement des Sciences Animales, Faculté des Sciences de l Agriculture et d Alimentation, Universite Laval, Ste Foy, Quebec, Canada G1K 7P4
    Mol Reprod Dev 70:361-72. 2005
    ..In conclusion, these results demonstrate that the control of meiotic resumption in porcine oocytes is highly regulated by cAMP. Both the degradation by specific PDE3 enzyme and the synthesis by an active AC are highly involved...
  5. pmc Transcriptional regulation of adipogenesis by KLF4
    Kivanc Birsoy
    Laboratory of Molecular Genetics, Rockefeller University, New York, NY 10021, USA
    Cell Metab 7:339-47. 2008
    ..KLF4 is specifically induced in response to cAMP, which by itself can partially activate adipogenesis. These data suggest that KLF4 functions as an immediate early regulator of adipogenesis to induce C/EBPbeta...
  6. ncbi cAMP increases surface expression of NKCC2 in rat thick ascending limbs: role of VAMP
    Pablo A Ortiz
    Hypertension and Vascular Research Division, Dept of Internal Medicine, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202, USA
    Am J Physiol Renal Physiol 290:F608-16. 2006
    ..min(-1).mm(-1); not significant). We concluded that cAMP increases NKCC2 surface expression by a mechanism involving VAMP and that NKCC2 trafficking to the apical membrane is involved in the stimulation of TAL NaCl absorption by cAMP...
  7. ncbi Electrophysiological characterization of rat and mouse olfactory receptor neurons from an intact epithelial preparation
    M Ma
    Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Neurosci Methods 92:31-40. 1999
    ....
  8. pmc Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation
    S D Munger
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 294:2172-5. 2001
    ..Thus, the CNGA4 subunit accelerates the Ca2+-mediated negative feedback in olfactory signaling and allows rapid adaptation in this sensory system...
  9. pmc Fast adaptation in mouse olfactory sensory neurons does not require the activity of phosphodiesterase
    Anna Boccaccio
    International School for Advanced Studies, S I S S A, Sector of Neurobiology, 34014 Trieste, Italy
    J Gen Physiol 128:171-84. 2006
    ..All together, these results indicate that the activity of ciliary PDE is not required for fast adaptation to repetitive stimuli in mouse olfactory sensory neurons...
  10. pmc Persistent activation of transducin by bleached rhodopsin in salamander rods
    H R Matthews
    Physiological Laboratory, University of Cambridge, United Kingdom
    J Gen Physiol 108:557-63. 1996
    ..This observation suggests that a form of rhodopsin which persists long after bleaching can activate transducin much as does photoisomerized rhodopsin, although with considerably lower gain...
  11. ncbi Differentiation of human dopamine neurons from an embryonic carcinomal stem cell line
    L Iacovitti
    Department of Neurology, Thomas Jefferson University Medical College, 1025 Walnut Street, Philadelphia, PA 19107, USA
    Brain Res 912:99-104. 2001
    ..Moreover, hNTs may serve, in vivo, as a source of human DA neurons for use in transplantation therapies...
  12. ncbi cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1
    Tuyen Hoang
    Hormone Laboratory, Section of Endocrinology, Institute of Medicine, Division of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen and Haukeland University Hospital, Bergen N 5021, Norway
    J Biol Chem 279:49120-30. 2004
    ..Taken together, these data demonstrate that GRIP1 is ubiquitinated and degraded through activation of the PKA pathway. This may represent a novel regulatory mechanism whereby hormones down-regulate a nuclear receptor coactivator...
  13. pmc Incomplete reversal of beta-adrenoceptor desensitization in human and guinea-pig cardiomyocytes by cyclic nucleotide phosphodiesterase inhibitors
    D G Wynne
    Department of Cardiac Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 109:1071-8. 1993
    ....
  14. pmc Cyclic nucleotide-gated ion channels in rod photoreceptors are protected from retinoid inhibition
    Quanhua He
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, MA 02114, USA
    J Gen Physiol 128:473-85. 2006
    ..Exceptionally high retinoid levels, e.g., associated with some retinal degenerations, could overcome the buffer, however, and impair sensitivity or delay the recovery after exposure to bright light...
  15. ncbi Control of cyclic AMP concentration in bovine endometrial stromal cells by arachidonic acid
    Z Cheng
    School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, UK
    Reproduction 133:1017-26. 2007
    ..The data suggest that arachidonic acid antagonizes PGE(2) signalling through cAMP in the bovine endometrium, possibly acting to ensure a rapid return to oestrus in the case of failure of the maternal recognition of pregnancy...
  16. ncbi Involvement of hyperpolarization-activated cation channels in synaptic modulation
    Marlène Genlain
    Laboratory of Neurosciences, University of Mons Hainaut, Mons, Belgium
    Neuroreport 18:1231-5. 2007
    ..This suggests that the Ih channel could be a bifunctional protein...
  17. ncbi Modulation of dihydropyridine-sensitive calcium channels in Drosophila by a cAMP-mediated pathway
    A Bhattacharya
    Department of Biochemical Pharmacology, State University of New York at Buffalo, 14260 1200, USA
    J Neurobiol 39:491-500. 1999
    ..The data also raise questions on the likely role of DHP-sensitive Ca2+ channel modulation in synaptic plasticity, and learning and memory, processes disrupted by the dnc and the rut mutations...
  18. ncbi Self-renewal and differentiation of mouse embryonic stem cells as measured by Oct4 expression: the role of the cAMP/PKA pathway
    S Faherty
    Department of Physiology, National University of Ireland, Galway, University Road, Galway, Ireland
    In Vitro Cell Dev Biol Anim 43:37-47. 2007
    ..This study clearly shows that the cAMP/PKA pathway plays a role in ES cell self-renewal pathways...
  19. ncbi Pituitary adenylate cyclase-activating polypeptide (PACAP) can act as determinant of the tyrosine hydroxylase phenotype of dopaminergic cells during retina development
    Juliana Carrazzoni Borba
    Laboratórios de Neuroquímica and Neurobiologia da Retina, Instituto de Biofisica Carlos Chagas Filho UFRJ, Centro de Ciências da Saúde Bloco G, Universidade Federal do Rio de Janeiro, Ilha do Fundao, Rio de Janeiro, RJ 21949 900, Brazil
    Brain Res Dev Brain Res 156:193-201. 2005
    ..Our data show that this peptide is an important factor influencing the definition of the tyrosine hydroxylase phenotype of retina dopaminergic cells within a narrow window of development...
  20. ncbi Circadian change of adenylate cyclase activity in rabbit ciliary processes
    H Nii
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT, USA
    Curr Eye Res 23:248-55. 2001
    ..There is a circadian rhythm of adenylate cyclase activity in rabbit ciliary processes that is driven in part by ocular sympathetic input and stimulation of beta-adrenergic receptors...
  21. ncbi Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland
    Chika Funaki
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Physiol Cell Physiol 293:C1551-60. 2007
    ..We conclude that increasing cellular cAMP levels inhibits p44/p42 MAPK activity and that this could account for potentiation of secretion obtained when cAMP was elevated and Ca(2+) and PKC were increased by agonists...
  22. ncbi Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels
    Hannah Murdoch
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Neurosci 27:9513-24. 2007
    ..Thus, genetic variation in DISC1 and PDE4 that influence either isoform expression or docking site functioning may directly affect psychopathology...
  23. ncbi Potentiation of ATP- and bradykinin-induced [Ca2+]c responses by PTHrP peptides in the HaCaT cell line
    Helen E Burrell
    Department of Human Anatomy and Cell Biology, University of Liverpool, Liverpool, UK
    J Invest Dermatol 128:1107-15. 2008
    ..Since PTHrP is found in many normal and malignant cells, potentiation is likely to have a wider role in modulating signal transduction events...
  24. ncbi Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes
    Manuela Zaccolo
    Department of Biomedical Sciences and Venetian Institute for Molecular Medicine, University of Padua, Via Orus 2, 35129 Padua, Italy
    Science 295:1711-5. 2002
    ..Furthermore, we demonstrate that such gradients of cAMP specifically activate a subset of protein kinase A molecules anchored in proximity to the T tubule...
  25. ncbi Glucocorticoid-stimulated lung epithelial Na(+) transport is associated with regulated ENaC and sgk1 expression
    Omar A Itani
    Department of Internal Medicine, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Am J Physiol Lung Cell Mol Physiol 282:L631-41. 2002
    ....
  26. ncbi Role of K(V)LQT1 in cyclic adenosine monophosphate-mediated Cl(-) secretion in human airway epithelia
    M Mall
    Universitäts Kinderklinik and Physiologisches Institut, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
    Am J Respir Cell Mol Biol 23:283-9. 2000
    ..Activation of K(V)LQT1 in CF airways in parallel with stimulation of residual CF transmembrane conductance regulator Cl(-) channel activity or alternative Cl(-) channels could help to circumvent the secretory defect...
  27. ncbi Triggering of insulin release by a combination of cAMP signal and nutrients: an ATP-sensitive K+ channel-independent phenomenon
    Mitsuhisa Komatsu
    Department of Aging Medicine and Geriatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Diabetes 51:S29-32. 2002
    ..In conclusion, a combination of cAMP signal and nutrients potently triggers insulin release under full activation of the K(ATP) channel, indicating the multiplicity of driving force for insulin exocytosis...
  28. ncbi BMP-2 stimulates tyrosinase gene expression and melanogenesis in differentiated melanocytes
    M L Bilodeau
    Basic Medical Sciences Department, Purdue University, West Lafayette, Indiana 47906, USA
    Pigment Cell Res 14:328-36. 2001
    ..These studies support a role for BMP-2 in melanogenesis by selectively targeting the expression of the tyrosinase gene involved in melanin biosynthesis...
  29. pmc Regulation of slowly activating potassium current (I(Ks)) by secretin in rat pancreatic acinar cells
    S J Kim
    Department of Physiology, Sungkyunkwan University School of Medicine, Suwon 440-746, Korea
    J Physiol 535:349-58. 2001
    ..The I(Ks) channel is a common target for both Ca(2+) and cAMP agonists. The vagal stimulation under the physiological concentration of secretin facilitates I(Ks), which provides an additional driving force for Cl(-) secretion...
  30. ncbi Mechanism of intracellular calcium ([Ca2+]i) inhibition of lipolysis in human adipocytes
    B Xue
    Department of Nutrition, The University of Tennessee, Knoxville, Tennessee 37996, USA
    FASEB J 15:2527-9. 2001
    ..In conclusion, increasing [Ca2+]i exerts an antilipolytic effect mainly by activation of PDE, leading to a decrease in cAMP and HSL phosphorylation and, consequently, inhibition of lipolysis...
  31. ncbi Regulation of UT-A1-mediated transepithelial urea flux in MDCK cells
    Otto Fröhlich
    Department of Physiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Physiol Cell Physiol 291:C600-6. 2006
    ....
  32. ncbi Role of the exchange protein directly activated by cyclic adenosine 5'-monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cells
    Shamim Lotfi
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, 67 College Street, Toronto, Ontario, Canada M5G 2M1
    Endocrinology 147:3727-36. 2006
    ..We therefore suggest that cAMP at least partially regulates proglucagon gene expression via the Epac-Ras/Rap-Raf-MEK-ERK signaling pathway...
  33. ncbi The role of intracellular cAMP in mediating the synchronizing action of noradrenaline on the evoked release of quanta of mediator in the frog synapse
    E A Bukharaeva
    Kazan' State Medical University, and Kazan' Institute of Biochemistry and Biophysics, Russia
    Neurosci Behav Physiol 31:473-80. 2001
    ..It was concluded that the action of noradrenaline on the time course of secretion is mediated by activation of presynaptic beta receptors, increased adenylate cyclase activity, and increases in intracellular cAMP levels...
  34. ncbi Adenylyl cyclase isoform-selective regulation of vascular smooth muscle proliferation and cytoskeletal reorganization
    Robert Gros
    Cell Biology Research Group, Robarts Research Institute, 100 Perth Dr, London, ON N6A 5K8, Canada
    Circ Res 99:845-52. 2006
    ..In aggregate, these findings suggest that isoform-selective signaling complexes likely contribute to various functional consequences of cAMP elevation in vascular smooth muscle cells...
  35. ncbi The phosphorylation of serine 492 of perilipin a directs lipid droplet fragmentation and dispersion
    Amy Marcinkiewicz
    Department of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA
    J Biol Chem 281:11901-9. 2006
    ..We conclude that protein kinase A-mediated phosphorylation of serine 492 of perilipin A drives the fragmentation and dispersion of lipid droplets...
  36. ncbi Beta-Adrenoceptor agonists and other cAMP elevating agents suppress PAI-1 production of human adipocytes in primary culture
    H Gottschling-Zeller
    , Clinical Department
    Horm Metab Res 32:509-14. 2000
    ..In conclusion, the results of this study support the assumption that catecholamines are able to down-regulate PAI-1 expression and secretion in human adipocytes via beta-adrenergic receptors...
  37. ncbi Cloning and function of the rat colonic epithelial K+ channel KVLQT1
    K Kunzelmann
    Department of Physiology and Pharmacology, University of Queensland St Lucia, Brisbane, Australia
    J Membr Biol 179:155-64. 2001
    ..We conclude that KVLQT1 is forming an important component of the basolateral cAMP-activated K+ conductance in the colonic epithelium and plays a crucial role in diseases like secretory diarrhea and cystic fibrosis...
  38. ncbi Mediation of adenylyl cyclase sensitization by PTX-insensitive GalphaoA, Galphai1, Galphai2 or Galphai3
    Mary J Clark
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan USA
    J Neurochem 99:1494-504. 2006
    ..This serum-mediated sensitization partially masked mu-opioid-mediated sensitization when expressed as percentage overshoot due to an apparent increase in AC activity...
  39. ncbi Structure-activity and possible mode of action of S-Iamide neuropeptides on identified central neurons of Helix aspersa
    S M Pedder
    Department of Physiology and Pharmacology, School of Biological Sciences, University of Southampton, Bassett Crescent East, SO16 7PX, Southampton, UK
    Regul Pept 101:131-40. 2001
    ..No evidence was found for an interaction with either guanylate cyclase or nitric oxide synthase...
  40. ncbi Cyclic AMP raises intracellular Ca(2+) in human megakaryocytes independent of protein kinase A
    Els den Dekker
    Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Center Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 22:179-86. 2002
    ..These findings reveal a novel mechanism for elevating cytosolic Ca(2+) by cAMP, possibly via GTP-Rap1...
  41. ncbi Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation
    Morten Asser Karsdal
    Nordic Bioscience Diagnostics, Herlev, Denmark
    Arthritis Rheum 56:1549-58. 2007
    ..One signaling pathway of calcitonin is via the second messenger cAMP. We undertook this study to investigate whether increased cAMP levels in chondrocytes would be chondroprotective...
  42. ncbi PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP
    Richard Lee
    Section of Hematology and Oncology, Department of Medicine, EBRC 420, Boston Medical Center, 650 Albany Street, Boston, MA 02118, USA
    Cell Signal 14:277-84. 2002
    ..84 microM. IC242-mediated up-regulation of PDE7A was blocked by the protein kinase A (PKA) inhibitor H-89...
  43. pmc Preferential potentiation of fast-releasing synaptic vesicles by cAMP at the calyx of Held
    T Sakaba
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, Am Fassberg, , Germany
    Proc Natl Acad Sci U S A 98:331-6. 2001
    ..cAMP increases the apparent Ca2+ sensitivity for secretion, but this increase does not reflect an increase in release probability necessarily but rather an increase in the number of highly sensitive vesicles...
  44. ncbi Protein secretion in cockroach salivary glands requires an increase in intracellular cAMP and Ca2+ concentrations
    K Rietdorf
    Institute of Biochemistry and Biology, Department of Animal Physiology, University of Potsdam, P O B 60 15 53, 14415 Potsdam, Germany
    J Insect Physiol 51:1083-91. 2005
    ..Our measurements suggest that 5-HT-induced protein secretion is mediated by an elevation of [cAMP]i and that Ca2+ may function as a co-agonist and augment the rate of protein secretion...
  45. ncbi The involvement of cyclic adenosine monophosphate in the control of schistosome miracidium cilia
    Hiroshi Matsuyama
    Department of Parasitology, Institute of Tropical Medicine, Nagasaki University, 1 12 4, Sakamoto, Nagasaki 852 8523, Japan
    J Parasitol 90:8-14. 2004
    ..These results suggest that cAMP and cAMP-dependent protein kinase are involved in osmosis-controlled ciliary motion of schistosome miracidia...
  46. ncbi Involvement of cyclic adenosine 3',5'-monophosphate in the differential regulation of activin betaA and betaB expression by gonadotropin in the zebrafish ovarian follicle cells
    Yajun Wang
    Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Endocrinology 144:491-9. 2003
    ..This suggests that the hCG-stimulated activin betaA expression is dependent on the activation of the cAMP-PKA pathway, whereas the inhibitory effect of hCG on activin betaB expression is likely mediated by PKA-independent pathway(s)...
  47. ncbi Adenylyl cyclase expression and modulation of cAMP in rat taste cells
    Tatjana Abaffy
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33101, USA
    Am J Physiol Cell Physiol 284:C1420-8. 2003
    ..Whether AC8 is directly involved in signal transduction of umami taste remains to be established...
  48. ncbi Regulation of growth hormone release in common carp pituitary cells by pituitary adenylate cyclase-activating polypeptide: signal transduction involves cAMP- and calcium-dependent mechanisms
    Dong Xiao
    Department of Zoology, University of Hong Kong, China
    Neuroendocrinology 76:325-38. 2002
    ..Apparently, the GH-releasing action of PACAP is mediated through the adenylate cyclase/cAMP/protein kinase A pathway and [Ca(2+)](e) influx through VSCC...
  49. ncbi Cyclic-AMP-dependent proliferation of a human osteoblast cell line (HOS cells) induced by hydroxyapatite: effect of exogenous nitric oxide
    Wihaskoro Sosroseno
    School of Dentistry, AIMST University, Semeling, Bedong 08100, Kedah Darul Aman, Malaysia
    Acta Biomed 79:110-6. 2008
    ..The aim of the present study was to test the hypothesis that exogenous NO may up-regulate the proliferation of hydroxyapatite (HA)-induced HOS cells via the cyclic-AMP-protein kinase A (PKA) pathway...
  50. ncbi Cyclic adenosine 3',5'-monophosphate regulation of corticotropin-releasing hormone promoter activity in AtT-20 cells and in a transformed hypothalamic cell line
    Maria Nikodemova
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 144:1292-300. 2003
    ..Furthermore, poor CRH promoter activation in AtT-20 cells appears to result from deficient cAMP production and rapid cAMP degradation by PDE...
  51. ncbi Inhibition of ovarian steroidogenesis by cyclic GMP in a fly
    G Maniere
    Universite Bordeaux I, Laboratoire de Neuroendocrinologie des Insectes, Avenue des Facultes, F 33405 Talence Cedex, France
    J Endocrinol 177:35-44. 2003
    ..These data thus demonstrate, for the first time in invertebrates, a potent role of cGMP in the negative control of ovarian steroidogenesis and suggest a possible co-regulation with NO...
  52. ncbi Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells
    Rosalba Salcedo
    Laboratory of Molecular Immunoregulation, Cancer Center Research, National Cancer Institute NIH, Bldg 567, Rm 210, Frederick, MD 21702, USA
    Blood 102:1966-77. 2003
    ..These findings indicate that PGE2 is a mediator of VEGF- and bFGF-induced CXCR4-dependent neovessel assembly in vivo and show that angiogenic effects of PGE2 require CXCR4 expression...
  53. ncbi Differential effects of cyclic AMP on induction of nitric oxide synthase in 3T3-L1 cells and brown adipocytes
    Kazushige Dobashi
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Free Radic Biol Med 35:94-101. 2003
    ..The differential regulation of iNOS in 3T3-L1 cells from that in the brown adipocytes indicates that intracellular signal pathways activated by cAMP are different between the cell types...
  54. ncbi Phosphodiesterase 8 (PDE8) regulates chemotaxis of activated lymphocytes
    Hongli Dong
    Department of Pharmacology, University of Connecticut Health Center, Farmington, CT 06030 6125, USA
    Biochem Biophys Res Commun 345:713-9. 2006
    ..These results suggest that in employing PDE inhibitor therapy for inflammatory illnesses, inhibition of PDE8 may be required to inhibit migration of activated lymphocytes to achieve a full therapeutic effect...
  55. ncbi "Low" concentrations of sodium fluoride inhibit neurotransmitter release from the guinea-pig superior cervical ganglion
    Pier Giorgio Borasio
    Department of Biology, Section of General Physiology, University of Ferrara, Via L Borsari 46, 44100 Ferrara, Italy
    Neurosci Lett 364:86-9. 2004
    ..Thus a NaF-sensitive G protein, linked to cAMP synthesis, is determinant for the inhibition of neurosecretion in this cholinergic synapse, involving Ca2+-dependent mechanisms...
  56. ncbi Myosin heavy chain isoforms expression and cyclic AMP concentrations in hypoxia-induced hypertrophied right ventricle in rats
    Takeshi Hashimoto
    Department of Environmental Physiology, Graduate School of Human and Environmental Studies, Kyoto University, Yoshida, Sakyo, Kyoto 606 8501, Japan
    Comp Biochem Physiol B Biochem Mol Biol 138:365-70. 2004
    ..These results provided evidence against the causal role for cAMP concentration in the expression of MHC-beta associated with hypoxia-induced ventricular hypertrophy...
  57. ncbi Second messengers of octopamine receptors in the snail Lymnaea
    Samantha Pitt
    Department of Biology, University of York, PO Box 373, York YO10 5YW, UK
    Acta Biol Hung 55:177-83. 2004
    ..Both cells are excited by forskolin. We conclude that the B1 neuron response to octopamine is likely to be mediated by cAMP, while the B2 and B3 responses are cAMP-independent...
  58. ncbi Termination of immediate-early gene expression after stimulation by parathyroid hormone or isoproterenol
    Xin Chen
    Department of Orthopaedics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106 5000, USA
    Am J Physiol Cell Physiol 283:C1432-40. 2002
    ..This conclusion may therefore reflect a general mechanism for termination of immediate-early gene expression after induction by cAMP/PKA...
  59. pmc Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259
    Amardeep S Dhillon
    The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom
    Mol Cell Biol 22:3237-46. 2002
    ..Using RafS259 mutants we also demonstrate that Raf-1 is the sole target for PKA inhibition of ERK and ERK-induced gene expression, and that Raf-1 inhibition is mediated mainly through serine 259 phosphorylation...
  60. ncbi Dynein-dynactin complex mediates protein kinase A-dependent clustering of Weibel-Palade bodies in endothelial cells
    Mariska G Rondaij
    Department of Plasma Proteins, Sanquin Research, University of Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 26:49-55. 2006
    ..In this study, we investigated this phenomenon of WPB clustering in more detail...
  61. ncbi Inhibition of cAMP accumulation by kappa-receptor activation in isolated iris-ciliary bodies: role of phosphodiesterase and protein kinase C
    Juanita Dortch-Carnes
    Department of Pharmacology Toxicology, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    J Pharmacol Exp Ther 301:599-604. 2002
    ..This mechanism of action could contribute to the ability of kappa-opioid agonists to suppress aqueous flow rate and to lower intraocular pressure...
  62. ncbi cAMP modulation of Ca(2+)-regulated exocytosis in ACh-stimulated antral mucous cells of guinea pig
    Takashi Nakahari
    Department of Physiology, Osaka Medical College, 2 7 Daigaku cho, Takatsuki 569 8686, Japan
    Am J Physiol Gastrointest Liver Physiol 282:G844-56. 2002
    ..In conclusion, cAMP accumulation increases the number of primed granules and Ca(2+) sensitivity of the fusion, which potentiates Ca(2+)-regulated exocytosis in antral mucous cells...
  63. ncbi Protein kinase-dependent and Ca(2+)-independent cAMP inhibition of ANP release in beating rabbit atria
    Xun Cui
    Department of Physiology, Institute for Medical Sciences, Jeonbug National University Medical School, JeonJu 561 180, Korea
    Am J Physiol Regul Integr Comp Physiol 282:R1477-89. 2002
    ..These results suggest that cAMP inhibits atrial myocytic release of ANP via protein kinase-dependent and L-type Ca(2+)-channel-dependent and -independent signaling pathways...
  64. ncbi Roles of cAMP in regulation of both MAP kinase and p34(cdc2) kinase activity during meiotic progression, especially beyond the MI stage
    Masayuki Shimada
    Faculty of Applied Biological Science, Hiroshima University, Higashi Hiroshima, Hiroshima 739 8528, Japan
    Mol Reprod Dev 62:124-31. 2002
    ....
  65. ncbi Protein kinase A-mediated phosphorylation of HERG potassium channels in a human cell line
    Zhang Wei
    Department of Cardiology, Medical University Hospital Heidelberg, Heidelberg, Germany
    Chin Med J (Engl) 115:668-76. 2002
    ..To investigate the molecular mechanism of human ether-a-go-go-related gene (HERG) potassium channels regulated by protein kinase A (PKA) in a human cell line...
  66. ncbi Receptor (MT(1)) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1
    Elmar Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Pineal Res 33:63-71. 2002
    ..From these data we conclude that the MT1 receptor is located on the INS-1 cell and therefore in general on pancreatic beta-cells...
  67. ncbi Heterologous sensitization of adenylate cyclase is protein kinase A-dependent in Cath.a differentiated (CAD)-D2L cells
    Christopher A Johnston
    Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, USA
    J Neurochem 82:1087-96. 2002
    ..The ability of ACVI to be negatively regulated by PKA is consistent with the observation that inhibition of PKA results in heterologous sensitization of adenylate cyclase activity in CAD-D2L cells...
  68. ncbi Altered phosphodiesterase 3-mediated cAMP hydrolysis contributes to a hypermotile phenotype in obese JCR:LA-cp rat aortic vascular smooth muscle cells: implications for diabetes-associated cardiovascular disease
    Stuart J Netherton
    Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
    Diabetes 51:1194-200. 2002
    ..Our data are consistent with an increased role for PDE3 in regulating cAMP-dependent signaling in cp/cp VSMCs and identify PDE3 as a cellular activity potentially responsible for the phenotype of cp/cp VSMCs...
  69. pmc Influence of nitric oxide synthase inhibition, nitric oxide and hydroperoxide on insulin release induced by various secretagogues
    G Panagiotidis
    Department of Pharmacology, University of Lund, Sweden
    Br J Pharmacol 114:289-96. 1995
    ..8. Taken together with previous data the present results suggest that islet production of low physiological levels of free radicals such as NO and H202 may serve as important modulators of insulin secretory processes...
  70. ncbi Role of cyclic adenosine 3',5'-monophosphate and serum albumin in head-to-head agglutination of boar spermatozoa
    H Harayama
    Department of Life Science, Graduate School of Science and Technology, Kobe University, Nada, Japan
    Reprod Fertil Dev 12:307-18. 2000
    ....
  71. pmc Inhibition of muscarinic receptor-induced inositol phospholipid hydrolysis by caffeine, beta-adrenoceptors and protein kinase C in intestinal smooth muscle
    S A Prestwich
    Department of Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, London
    Br J Pharmacol 114:602-11. 1995
    ..Diacylglycerols may exert a negative feedback inhibition on inositol phosphate production...
  72. pmc The effect of cyclic AMP and cyclic GMP phosphodiesterase inhibitors on the superoxide burst of guinea-pig peritoneal macrophages
    N C Turner
    Dagenham Research Centre, Rhone Poulenc Rorer Ltd, Dagenham, Essex
    Br J Pharmacol 108:876-83. 1993
    ..Inhibition of spontaneous superoxide generation, but not that stimulated by FMLP, suggests that the activity of PDE inhibitors is subject to functional antagonism but that this can be overcome by enhancing cyclic AMP formation...
  73. pmc Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils
    E Talpain
    Department of Pharmacology, University of Edinburgh
    Br J Pharmacol 114:1459-65. 1995
    ..1 AM in its presence.9. These results suggest that inhibition of superoxide generation by PGE2 is mediated by stimulation ofEP2 receptors and activation of adenylate cyclase, leading to the elevation of intracellular levels of cyclic AMP...
  74. ncbi Phosphodiesterase inhibitor 3-isobutyl-methyl-xanthine stimulates reproduction in rabbit females
    A V Sirotkin
    Institute of Genetics and Animal Reproduction, Animal Production Research Centre Nitra, LuZianky near Nitra, Slovak Republic
    Theriogenology 74:1321-6. 2010
    ....
  75. ncbi The role of phosphodiesterase isoforms 2, 5, and 9 in the regulation of NO-dependent and NO-independent cGMP production in the rat cervical spinal cord
    J de Vente
    European Graduate School of Neuroscience EURON, Maastricht University, Department of Psychiatry and Neuropsychology, UNS50, POB 616, 6200 MD Maastricht, The Netherlands
    J Chem Neuroanat 31:275-303. 2006
    ..cGMP levels in the spinal cord are controlled by the concerted action of a number of PDE isoforms, which can be present in the same cell...
  76. pmc Evidence that M1 muscarinic receptors enhance noradrenaline release in mouse atria by activating protein kinase C
    M Costa
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Br J Pharmacol 110:910-6. 1993
    ..This provides evidence that activation of protein kinase C is involved in the signal transduction process of McNeil A 343...
  77. pmc Control of cyclic AMP levels in primary cultures of human tracheal smooth muscle cells
    I P Hall
    Department of Therapeutics, University Hospital of Nottingham
    Br J Pharmacol 107:422-8. 1992
    ....
  78. ncbi Oxygen consumption in the rat outer and inner retina: light- and pharmacologically-induced inhibition
    C J Medrano
    College of Optometry, University of Houston, Texas 77204 6052, USA
    Exp Eye Res 61:273-84. 1995
    ..abstract truncated at 400 words)..
  79. ncbi Relationship between bicarbonate and cyclic nucleotide in the promoting effects on head-to-head agglutination in boar spermatozoa
    Hiroshi Harayama
    Department of Life Science, Graduate School of Science and Technology, Kobe University, Kobe 657 8501, Japan
    Asian J Androl 4:87-96. 2002
    ..To clarify the relationship between bicarbonate and cAMP in the promoting effects on the sperm agglutination...
  80. ncbi Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity
    P Le Goff
    Department of Physiology and Biophysics, University of Illinois, Urbana 61801
    J Biol Chem 269:4458-66. 1994
    ..Our studies identify several serines in the NH2-terminal portion of the human ER as being major hormone-regulated phosphorylation sites.(ABSTRACT TRUNCATED AT 250 WORDS)..
  81. pmc Investigation of the 5-hydroxytryptamine receptor mediating the 'maintained' short-circuit current response in guinea-pig ileal mucosa
    C M Scott
    Department of Gastrointestinal Pharmacology, Glaxo Group Research Ltd, Ware, Herts
    Br J Pharmacol 106:877-82. 1992
    ..7. A possible interpretation of these results is that the 'maintained' SCC response to 5-HT is mediated by a heterogeneous population of 5-HT receptors. One of these receptors exhibits the characteristics of the putative 5-HT4 receptor...
  82. pmc The presence of five cyclic nucleotide phosphodiesterase isoenzyme activities in bovine tracheal smooth muscle and the functional effects of selective inhibitors
    M Shahid
    Organon Laboratories Limited, Newhouse, Lanarkshire, United Kingdom
    Br J Pharmacol 104:471-7. 1991
    ..5. We conclude that bovine tracheal smooth muscle contains five distinct PDE isoenzymes. PDE IV appears to be more important in the modulation of tissue function than PDE III and PDE V...
  83. ncbi Regulation of human extraneuronal monoamine transporter (hEMT) expressed in HEK293 cells by intracellular second messenger systems
    F Martel
    Department of Biochemistry, Faculty of Medicine, Porto, Portugal
    Naunyn Schmiedebergs Arch Pharmacol 364:487-95. 2001
    ..showed an increase in the presence of exogenous alkaline phosphatase. In conclusion, these results suggest that hEMT is regulated by phosphorylation/dephosphorylation mechanisms, being active in the dephosphorylated state...
  84. ncbi Genistein stimulates electrogenic Cl- secretion via phosphodiesterase modulation in the mouse jejunum
    Pin Chun Chao
    Dept of Physiology, School of Medical Sciences, Univ of Otago, P O Box 913, Dunedin, New Zealand
    Am J Physiol Cell Physiol 297:C688-98. 2009
    ..Likewise, H89 reduced the genistein-stimulated I(sc). Here, we demonstrate, for the first time, that genistein activates Cl(-) secretion of the mouse jejunum via inhibition of a PDE3-dependent pathway...
  85. ncbi On the role of Ca2(+)-calmodulin-dependent and cAMP-dependent protein phosphorylation in the circadian rhythm of Neurospora crassa
    D Techel
    Department of Biology, University of Bremen, Federal Republic of Germany
    J Comp Physiol B 159:695-706. 1990
    ..Ca2+ calmodulin and the phosphorylation state of the 47/48-kDa proteins may have controlling or essential functions for this mechanism...
  86. ncbi The opposite effects of cyclic AMP-protein kinase a signal transduction pathway on renal cortical and medullary Na+,K+-ATPase activity
    J Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    J Physiol Pharmacol 53:211-31. 2002
    ..The inhibitory effect is partially mediated by cytochrome P450-dependent arachidonate metabolites and possibly also by PKA-dependent inhibition of protein phosphatases...
  87. pmc Potentiation by forskolin of both SNP- and ANP-stimulated cyclic GMP accumulation in porcine isolated palmar lateral vein
    I K Wright
    Department of Physiology and Pharmacology, Medical School, Queen s Medical Centre, Nottingham
    Br J Pharmacol 112:1146-50. 1994
    ..Further, the ability of cyclic AMP to influence cyclic GMP levels may indicate that the two nucleotides, as well as having independent mechanisms to induce smooth muscle relaxation, could produce vasodilatation via a common mechanism...
  88. ncbi Cyclic GMP/cyclic GMP-dependent protein kinase system prevents excitotoxicity in an immortalized oligodendroglial cell line
    A Yoshioka
    Department of Neurology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    J Neurochem 74:633-40. 2000
    ..RT-PCR and westem blotting of OLC demonstrated transcription of PKG II gene and translation of PKG Ibeta mRNA, but no translation of PKG Ialpha mRNA. Therefore, we concluded that the cyclic GMP/PKG system prevents OLC excitotoxicity...
  89. ncbi Anion channels in a leaky epithelium. A patch-clamp study of choroid plexus
    O Christensen
    Department of General Physiology and Biophysics, Panum Institute, University of Copenhagen, Denmark
    Pflugers Arch 415:37-46. 1989
    ..KCl exit from the cell is suggested to be carried by KCl-cotransport or by channels that are too small to be seen in patch-clamp experiments...
  90. pmc Modulation of AMPA receptors by cAMP-dependent protein kinase in preBötzinger complex inspiratory neurons regulates respiratory rhythm in the rat
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    J Physiol 547:543-53. 2003
    ..Moreover, the basal level of endogenous PKA activity appears to be a determinant of resting respiratory frequency...
  91. ncbi Effects of ethanol on basal and adenosine-induced increases in beta-endorphin release and intracellular cAMP levels in hypothalamic cells
    N Boyadjieva
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164 6520, USA
    Brain Res 824:112-8. 1999
    ..Chronic ethanol desensitizes the adenosine-regulated cAMP production and IR-beta-EP release from hypothalamic neurons...
  92. ncbi Vascular beta-adrenergic receptor adenylyl cyclase system in maturation and aging
    M A Gaballa
    Departments of Internal Medicine, Veterans Administration Medical Center and University of Arizona Sarver Heart Center, Tucson, AZ, USA
    J Mol Cell Cardiol 32:1745-55. 2000
    ..e. possibly in the receptor-G protein coupling...
  93. pmc Effects of type-selective phosphodiesterase inhibitors on glucose-induced insulin secretion and islet phosphodiesterase activity
    R Shafiee Nick
    Department of Physiology and Pharmacology, University of Strathclyde, Glasgow
    Br J Pharmacol 115:1486-92. 1995
    ..9 These data are consistent with the presence of a type III PDE in rat islets of Langerhans...
  94. ncbi The role of alpha-MSH, its agonists, and C-AMP in in vitro avian melanocytes
    R R Bowers
    Department of Biology and Microbiology, California State University, Los Angeles 90032, USA
    Pigment Cell Res 10:41-5. 1997
    ..Evidently the more lipophilic 8-bromo-c-AMP was able to enter these cells and stimulate melanogenesis...
  95. ncbi The role of cyclic nucleotides and calcium in the relaxation produced by amrinone in rat aorta
    A van der Zypp
    Department of Medical Laboratory Science, RMIT University, PO Box 71, Bundoora, Victoria 3083, Australia
    Gen Pharmacol 34:245-53. 2000
    ....
  96. ncbi A novel cAMP-stimulated pathway in protein phosphatase 2A activation
    Marina S Feschenko
    Laboratory of Membrane Biology, Neuroscience Center, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    J Pharmacol Exp Ther 302:111-8. 2002
    ..Because PP2A is active toward a variety of endogenous substrates, cAMP-stimulated dephosphorylation may have complicated the interpretation of many prior studies...
  97. ncbi Different role of cAMP dependent protein kinase and CaMKII in H3 receptor regulation of histamine synthesis and release
    D Moreno-Delgado
    Universitat Autonoma de Barcelona, Neuroscience Institute and Department of Biochemistry and Molecular Biology, School of Medicine, 08193 Bellaterra, Spain
    Neuroscience 164:1244-51. 2009
    ..These results indicate that H(3) autoreceptors regulate neuronal histamine release (1) independently of the cAMP/PKA cascade, and (2) through modulation of calcium entry and CaMKII activation during depolarization...
  98. ncbi In vivo effects of phosphodiesterase inhibition on basal cyclic guanosine monophosphate levels in the prefrontal cortex, hippocampus and cerebellum of freely moving rats
    Antonella Marte
    Pharmacology and Toxicology Section, Department of Experimental Medicine, University of Genoa, Genoa, Italy
    J Neurosci Res 86:3338-47. 2008
    ....
  99. ncbi Meiosis-activating sterol promotes resumption of meiosis in mouse oocytes cultured in vitro in contrast to related oxysterols
    C Grøndahl
    Health Care Discovery, Novo Nordisk A S, Copenhagen, Denmark
    Biol Reprod 58:1297-302. 1998
    ..In contrast, the oxysterols and cholesterol had no significant biological activity on this oocyte function, and consequently we found no correlation between LXRalpha activation and meiosis stimulation...
  100. pmc Role of cyclic AMP in promoting the thromboresistance of human endothelial cells by enhancing thrombomodulin and decreasing tissue factor activities
    G Archipoff
    Centre Regional de Transfusion Sanguine, INSERM U 311, Strasbourg, France
    Br J Pharmacol 109:18-28. 1993
    ..7. Our data suggest that elevation of intracellular cyclic AMP levels may participate in the regulation of tissue factor and thrombomodulin expression, thus contributing to promote or restore antithrombotic properties of the endothelium...
  101. ncbi Differential regulation of matrix metalloproteinase-9 and tissue plasminogen activator activity by the cyclic-AMP system in lipopolysaccharide-stimulated rat primary astrocytes
    Soon Young Lee
    Department of Pharmacology, School of Medicine and Center for Geriatric Neuroscience Research, Institute of Biomedical Science and Technology, Konkuk University, 1 Hwayang dong, Gwangjin gu, Seoul, 143 701, South Korea
    Neurochem Res 33:2324-34. 2008
    ..The differential regulation of MMP-9 and tPA by the cAMP system may confer more sophisticated regulation of physiological processes, such as extracellular matrix remodeling and cell migration, by activated astrocytes...

Research Grants45

  1. Requirement for Glucocorticoids for Adipogenesis in vivo.
    Charles A Harris; Fiscal Year: 2012
    ..These Aims should answer the question as to whether glucocorticoid ligand and receptor are required for adipogenesis in vivo. ..
  2. Cyclic GMP Phosphodiesterase in Signaling
    Hsien Yu Wang; Fiscal Year: 2007
    ..These studies are highly relevant to signaling as well as to elucidation of basis for human diseases in which alterations in signaling pathways translate into aberrant biology. ..
  3. REGULATION OF GROWTH AND DIFFERENTIATION BY RETINOIDS
    Richard Niles; Fiscal Year: 1990
    ..The studies outlined in this proposal will provide new insights into these mechanisms...
  4. RPE TRANSEPITHELIAL TRANSPORT
    DONALD FRAMBACH; Fiscal Year: 1992
    ..4)to incorporate measurements of trans-RPE fluid fluxes into these studies so that fluid fluxes can be measured directly rather than calculated from isotope fluxes which are subject to cumulative experimental errors...
  5. Neurotoxicant Disruption of Astroglial Differentiation
    Timothy Zacharewski; Fiscal Year: 2003
    ..Moreover, these studies will further characterize the SVG cell line as an innovative CNS cell model that can be used for elucidating the cell specific mechanisms of action of developmental neurotoxicants. ..
  6. INTERACTION OF CFTR AND EPITHELIAL NA CHANNELS
    Douglas Eaton; Fiscal Year: 2003
    ..These studies will provide new information about mechanisms of coordinate regulation of epithelial Na and C1 transport. ..
  7. TRANSMEMBRANE MOVEMENTS
    ALBERT ROOS; Fiscal Year: 1991
    ..General methods: electrophysiological methods, intracellular pH- sensitive microelectrodes...
  8. Role of Regulated CIC CI Channels in CI Secretion in CF
    John Cuppoletti; Fiscal Year: 2006
    ..2 K channel in CF. This will also be studied in terms of CI transport, Na transport, CLCA2 function, inflammation and bacterial susceptibility. ..
  9. CHLORIDE CHANNELS AND GASTRIC ACID SECRETION
    John Cuppoletti; Fiscal Year: 2003
    ..These studies strive to address the fundamental questions regarding the molecules and mechanisms involved in regulated HCl secretion. ..
  10. CYCLIC AMP/ADENOSINE PATHWAY
    Edwin Jackson; Fiscal Year: 2002
    ..abstract_text> ..
  11. Sgk1 in Na+ transport in fetal lung epithelia
    Christie Thomas; Fiscal Year: 2007
    ..abstract_text> ..
  12. REGULATION AND FUNCTION OF THE ALPHA SUBUNIT OF ENAC
    Christie Thomas; Fiscal Year: 2003
    ..The long-term objectives are to understand the regulation and function of ENaC in transepithelial Na+ transport. ..
  13. Volume Regulatory Pathways in Cystic Fibrosis Mice
    Won Kyoo Cho; Fiscal Year: 2003
    ..abstract_text> ..
  14. BILIARY SECRETORY PATHWAYS IN CYSTIC FIBROSIS
    Won Kyoo Cho; Fiscal Year: 2003
    ..abstract_text> ..
  15. Regulation of Mammalian Oocyte Maturation
    Stephen Downs; Fiscal Year: 2007
    ..Furthermore, these studies will benefit the development of in vitro systems where either meiotic arrest or completion of meiotic maturation is the desired endpoint. ..
  16. FEMALE SEXUAL AROUSAL: CLITORAL AND VAGINAL PHYSIOLOGY
    Abdulmaged Traish; Fiscal Year: 2003
    ....
  17. Cyclic AMP signaling in cardiac myocytes
    THOMAS RICH; Fiscal Year: 2007
    ..g., protenoid, beta1-,or beta2-adrenergic receptors) or inhibit phosphodiesterase (PDE) will shed new light on the physiologic functions of these enzymes and their relation to cardiac function. ..
  18. Molecular Control of cGMP Signaling by PKGs and PDEs
    Jackie Corbin; Fiscal Year: 2007
    ..A thorough physical and biochemical characterization of PDE11 will be carded out, and the likelihood of regulation of this enzyme by ligand binding to its GAF domains or by enzyme phosphorylation will be explored. ..
  19. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  20. Mechanisms of ATP Release from RBC's
    Randy Sprague; Fiscal Year: 2007
    ..abstract_text> ..
  21. Fluid Movement across Conjunctiva: Stimulation and Regulation
    OSCAR CANDIA; Fiscal Year: 2007
    ..These studies may provide the groundwork for the design of future treatment modalities for dry-eye syndromes. ..
  22. Engineering a CFTR Deficient Porcine Model of CF
    SCOTT O GRADY; Fiscal Year: 2007
    ..abstract_text> ..
  23. Commensals and Probiotics: Role in Intestinal Physiology
    Silvia Resta Lenert; Fiscal Year: 2008
    ....
  24. Physiogical Control of Neuroblast Polarity in Drosophila
    Kenneth Robinson; Fiscal Year: 2005
    ..Endogenous electric fields are ubiquitous in development and arise whenever an epithelial layer is damaged, so these results will have implications for understanding development as well as wound healing. ..
  25. Salt Absorption by the THAL: Role of NKCC2 trafficking
    Pablo A Ortiz; Fiscal Year: 2010
    ..Data from this proposal will increase our understanding of how salt absorption by the THAL is regulated in normal and salt-sensitive animals, and will identify new targets for the development of diuretics. ..
  26. cAMP Phosphodiesterase and Lung Endothelial Cell Permeability
    Thomas C Rich; Fiscal Year: 2010
    ..Here we propose to determine whether pharmacological and molecular inhibitors of a specific protein, phosphodiesterase type 7, prevent increases in endothelial permeability in these arteries, and hence, make breathing easier. ..
  27. Dual Oxidase in Lung Epithelium
    HORST B FISCHER; Fiscal Year: 2011
    ..This research investigates a novel area of lung anti-microbial defense and will provide new information that may lead to therapeutic application. ..
  28. Transcriptional Control of Hemoglobin Synthesis
    Emery H Bresnick; Fiscal Year: 2010
    ..Through the assembly of a database of GRC parameters and computational/statistical analysis, hypotheses regarding determinants of GATA factor occupancy will be tested. ..
  29. Modulation of K channels in renal collecting duct
    Wen Hui Wang; Fiscal Year: 2007
    ....
  30. Measurement of Fluid Flow Across the Ocular Ciliary Body
    OSCAR CANDIA; Fiscal Year: 2006
    ..abstract_text> ..
  31. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  32. ALVEOLAR TYPE II CELL GROWTH IN INJURY
    RANDOLPH HASTINGS; Fiscal Year: 2003
    ..The project will evaluate the potential use of PTHrP-related therapeutic interventions that might speed or improve recovery following silica-induced lung injury. ..
  33. SOLUTE AND FLUID TRANSPORT ACROSS THE CONJUNCTIVA
    OSCAR CANDIA; Fiscal Year: 2002
    ..Based on this model, he will devise protocols to modify and possibly reverse the secretory/absorptive properties of the tissue. ..
  34. Stem cell-based therapy in heart failure: aging effects
    Mohamed Gaballa; Fiscal Year: 2003
    ..abstract_text> ..
  35. SEXUAL DIFFERENTIATION OF MOUSE VOMERONASAL FUNCTION
    James Cherry; Fiscal Year: 2004
    ....
  36. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  37. Role of Erythrocytes in Circulatory Control
    Randy Sprague; Fiscal Year: 2004
    ..abstract_text> ..
  38. Transcriptional Control of Hematopoietic Stem Cells
    EMERY BRESNICK; Fiscal Year: 2005
    ..The studies will define the regulation and function of GATA-2 as a prelude to developing principles for how chromatin domains and transcriptional networks assemble in and control HSCs. ..
  39. Molecular Mechanisms of PDE5 Regulation
    Jackie Corbin; Fiscal Year: 2005
    ..Results of these studies will provide a basis for understanding fundamental questions relating to cGMP signaling in many tissues. ..
  40. Sympathetic Modulation of the Immune System in Aging
    Denise Bellinger; Fiscal Year: 2005
    ..Specific Aim 3 explores possible mechanisms responsible for the age-related differences in sympathetic innervation of secondary lymphoid organs from these two rat strains. ..
  41. Light Adaptation in Vertebrate Rod Photoreceptors
    CLINT MAKINO; Fiscal Year: 2005
    ..Aberrant responses occur with higher frequency in some human retinal diseases and severely limit the intensity range of scotopic vision. ..
  42. NOX-mediated proton secretion by airways
    Horst Fischer; Fiscal Year: 2006
    ..This will help develop novel therapeutical targets for the treatment of airway acidity and inflammatory airway diseases. ..
  43. Coactivators that Mediate Beta-Globin LCR Function
    EMERY BRESNICK; Fiscal Year: 2006
    ..The long-term objective is to therapeutically control beta-globin genes in humans with hemoglobinopathies by regulating specific steps of the LCR mechanism. ..
  44. Mechanisms of Psychosocial Influences on Prostate Cancer
    Denise Bellinger; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  45. REGULATION OF THE CAMP SPECIFIC PHOSPHODIESTERASES
    Graeme Bolger; Fiscal Year: 2003
    ..5. The two-hybrid system will be used to clone cDNAs encoding proteins that interact with 4 novel PDE4 isoforms. ..