pentoxifylline

Summary

Summary: A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production.

Top Publications

  1. ncbi Successful treatment of refractory mucosal leishmaniasis with pentoxifylline plus antimony
    H A Lessa
    , , Faculdade de Medicina da Universidade Federal da Bahia, Salvador-Bahia, Brazil
    Am J Trop Med Hyg 65:87-9. 2001
  2. ncbi Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain
    Joanna Mika
    Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Cracow, Poland
    Eur J Pharmacol 560:142-9. 2007
  3. ncbi Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis
    Sylvie Delanian
    service d oncologie radiothérapie, Hopital Saint Louis 1, Paris, France
    J Clin Oncol 21:2545-50. 2003
  4. pmc Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism
    Claudia O Zein
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44915, USA
    Hepatology 56:1291-9. 2012
  5. pmc Pilot study of pentoxifylline in hepatopulmonary syndrome
    Rajasekhar Tanikella
    Liver Center, Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
    Liver Transpl 14:1199-203. 2008
  6. pmc Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trial
    Claudia O Zein
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44915, USA
    Hepatology 54:1610-9. 2011
  7. ncbi Therapy of ischemic cardiomyopathy with the immunomodulating agent pentoxifylline: results of a randomized study
    Karen Sliwa
    Department of Cardiology, Chris Hani Baragwanath Hospital, Johannesburg, South Africa
    Circulation 109:750-5. 2004
  8. pmc Pentoxifylline enhances the radioprotective properties of γ-tocotrienol: differential effects on the hematopoietic, gastrointestinal and vascular systems
    Maaike Berbee
    Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Radiat Res 175:297-306. 2011
  9. pmc Immunological mechanisms of pentoxifylline in chronic heart failure
    Steven M Shaw
    The Transplant Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester M23 9LT, UK
    Eur J Heart Fail 11:113-8. 2009
  10. pmc Prevention and treatment of functional and structural radiation injury in the rat heart by pentoxifylline and alpha-tocopherol
    Marjan Boerma
    Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Int J Radiat Oncol Biol Phys 72:170-7. 2008

Detail Information

Publications273 found, 100 shown here

  1. ncbi Successful treatment of refractory mucosal leishmaniasis with pentoxifylline plus antimony
    H A Lessa
    , , Faculdade de Medicina da Universidade Federal da Bahia, Salvador-Bahia, Brazil
    Am J Trop Med Hyg 65:87-9. 2001
    ..an open-label study was performed to evaluate the efficacy of the treatment with an inhibitor of TNF-alpha (pentoxifylline) associated to antimony therapy in 10 patients with refractory mucosal leishmaniasis...
  2. ncbi Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain
    Joanna Mika
    Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Cracow, Poland
    Eur J Pharmacol 560:142-9. 2007
    ..In mice, i.p., administration of minocycline (30 mg/kg) or pentoxifylline (20 mg/kg) according to the same schedule also significantly decreased allodynia and hyperalgesia on day 7 ..
  3. ncbi Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis
    Sylvie Delanian
    service d oncologie radiothérapie, Hopital Saint Louis 1, Paris, France
    J Clin Oncol 21:2545-50. 2003
    ..RIF treatment with a combination of pentoxifylline (PTX) and alpha-tocopherol (vitamin E; Vit E) was recently prompted by the good results of a clinical trial ..
  4. pmc Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism
    Claudia O Zein
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44915, USA
    Hepatology 56:1291-9. 2012
    b>Pentoxifylline (PTX) improved the histological features of nonalcoholic steatohepatitis (NASH) in a recent randomized placebo-controlled trial...
  5. pmc Pilot study of pentoxifylline in hepatopulmonary syndrome
    Rajasekhar Tanikella
    Liver Center, Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
    Liver Transpl 14:1199-203. 2008
    ..tumor necrosis factor alpha (TNF-alpha) overproduction contributes to vasodilatation, which is improved by pentoxifylline, a TNF-alpha inhibitor. The effectiveness of pentoxifylline in humans is unknown...
  6. pmc Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trial
    Claudia O Zein
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44915, USA
    Hepatology 54:1610-9. 2011
    The primary aim of this study was to compare the effects of pentoxifylline (PTX) versus placebo on the histological features of nonalcoholic steatohepatitis (NASH)...
  7. ncbi Therapy of ischemic cardiomyopathy with the immunomodulating agent pentoxifylline: results of a randomized study
    Karen Sliwa
    Department of Cardiology, Chris Hani Baragwanath Hospital, Johannesburg, South Africa
    Circulation 109:750-5. 2004
    ..We sought to determine whether the immunomodulating agent pentoxifylline enhances left ventricular function in patients with ischemic cardiomyopathy...
  8. pmc Pentoxifylline enhances the radioprotective properties of γ-tocotrienol: differential effects on the hematopoietic, gastrointestinal and vascular systems
    Maaike Berbee
    Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Radiat Res 175:297-306. 2011
    ..a) determine whether the efficacy of GT3 can be enhanced by the addition of the phosphodiesterase inhibitor pentoxifylline (PTX) and (b) to obtain information about the mechanism of action...
  9. pmc Immunological mechanisms of pentoxifylline in chronic heart failure
    Steven M Shaw
    The Transplant Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester M23 9LT, UK
    Eur J Heart Fail 11:113-8. 2009
    ..Conversely, a possible exception is pentoxifylline (PTX), a putative TNF-alpha inhibitor with possible (but ill-defined) vasodilatory properties...
  10. pmc Prevention and treatment of functional and structural radiation injury in the rat heart by pentoxifylline and alpha-tocopherol
    Marjan Boerma
    Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Int J Radiat Oncol Biol Phys 72:170-7. 2008
    Radiation-induced heart disease (RIHD) is a severe side effect of thoracic radiotherapy. This study examined the effects of pentoxifylline (PTX) and alpha-tocopherol on cardiac injury in a rat model of RIHD.
  11. pmc Pentoxifylline sensitizes human cervical tumor cells to cisplatin-induced apoptosis by suppressing NF-kappa B and decreased cell senescence
    Georgina Hernandez-Flores
    División de Inmunología, Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico
    BMC Cancer 11:483. 2011
    ..In some types of cancers pentoxifylline (PTX) sensitizes these cells to the toxic action of chemotherapeutics drugs such as adriamycin, inducing ..
  12. ncbi Oral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasis
    Paulo R L Machado
    Servico de Imunologia, Hospital Universitario Prof Edgard Santos, Universidade Federal da Bahia, Salvador Bahia, Brazil
    Clin Infect Dis 44:788-93. 2007
    ..We previously showed that an inhibitor of tumor necrosis factor-alpha (pentoxifylline) combined with Sb(v) cured 90% patients refractory to monotherapy with Sb(v).
  13. pmc Sensitization of cervix cancer cells to Adriamycin by Pentoxifylline induces an increase in apoptosis and decrease senescence
    Alejandro Bravo-Cuellar
    División de Inmunología, Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada 800, Colonia Independencia, Guadalajara, Jalisco, CP 44340, Mexico
    Mol Cancer 9:114. 2010
    ..The methylxantine drug Pentoxifylline (PTX) used routinely in the clinics setting for circulatory diseases has been recently described to have ..
  14. ncbi Effects of tranilast and pentoxifylline in a mouse model of chronic asthma using house dust mite antigen
    Seung Joon Kim
    Division of Pulmonology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137 040, Korea
    J Asthma 46:884-94. 2009
    ..b>Pentoxifylline (PTX), a methylxanthine derivative, is a potent anti-inflammatory drug that is known to manifest its effect ..
  15. ncbi Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis
    Sylvie Delanian
    service d oncologie radiothérapie, Hopital Saint Louis, 1 Ave Claude Vellefaux, 75010 Paris, France
    J Clin Oncol 23:8570-9. 2005
    Significant regression of radiation (RT) -induced fibrosis (RIF) has been achieved after treatment combining pentoxifylline (PTX) and alpha-tocopherol (vitE)...
  16. ncbi Effect of pentoxifylline on the healing of ischemic colorectal anastomoses
    Pablo Parra-Membrives
    Department of General and Digestive Surgery, Hospital Universitario de Valme, Seville, Spain
    Dis Colon Rectum 50:369-75. 2007
    The aim of this study was to evaluate the effect of pentoxifylline on the healing of experimental ischemic colorectal anastomoses.
  17. ncbi Clinical use of pentoxifylline for activation of immotile testicular sperm before ICSI in patients with azoospermia
    Borut Kovacic
    Department of Reproductive Medicine and Gynecologic Endocrinology, Maribor Teaching Hospital, Ljubljanska 5, SI 2000 Maribor, Slovenia
    J Androl 27:45-52. 2006
    ..study was to assess the effect of short exposure of testicular samples with only immotile sperm to pentoxifylline (PF)-sperm motility stimulator. In 77 of 294 (26...
  18. ncbi Effects of the tumour necrosis factor-alpha inhibitors pentoxifylline and thalidomide in short-term experimental oral mucositis in hamsters
    V Lima
    Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Rua Coronel Nunes de Melo 1127, Rodolfo Teófilo CEP 60430 270, Fortaleza, Ceara, Brazil
    Eur J Oral Sci 113:210-7. 2005
    ..A definitive method of prophylaxis or treatment is not yet available. As pentoxifylline (PTX) and thalidomide (TLD) have been shown to inhibit cytokine synthesis, we studied the effects of these ..
  19. ncbi Effect of pentoxifylline and tocopherol on radiation proctitis/enteritis
    Andrea Hille
    Department of Radiotherapy and Radiation Oncology, University of Goettingen, Germany
    Strahlenther Onkol 181:606-14. 2005
    ..There is some evidence that the combined treatment with pentoxifylline and tocopherol might alter the pathogenesis of radiation-induced fibrosis...
  20. ncbi The use of a combination of pentoxifylline and tocopherol in women with a thin endometrium undergoing assisted conception therapies--a report of 20 cases
    Santanu Acharya
    Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, Leeds General Infirmary, Leeds, UK
    Hum Fertil (Camb) 12:198-203. 2009
    ..We conclude that a combination of pentoxyfylline and tocopherol may improve endometrial growth in resistant cases that are unresponsive to conventional therapy...
  21. ncbi Pentoxifylline in ischemic, hypertensive and idiopathic-dilated cardiomyopathy: effects on left-ventricular function, inflammatory cytokines and symptoms
    Philipp Bahrmann
    Clinic of Internal Medicine I, Friedrich Schiller University, Erlanger Allee 101, 07740 Jena, Germany
    Eur J Heart Fail 6:195-201. 2004
    ..b>Pentoxifylline, a xanthin-derived agent, is known to inhibit the production of TNF-alpha and IL-6...
  22. ncbi Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol
    S Delanian
    service d oncologie radiothérapie, Hopital Saint Louis, Paris, France
    J Clin Oncol 17:3283-90. 1999
    ..RIF treatment with combined pentoxifylline (PTX) and tocopherol (Vit E) was prompted by recent advances in cellular and molecular biology that have ..
  23. ncbi Preclinical evaluation of the antimetastatic efficacy of Pentoxifylline on A375 human melanoma cell line
    Mohammed Zahid Kamran
    Gude Lab, Advanced Centre for Treatment, Research and Education in Cancer ACTREC, Tata Memorial Centre, Kharghar, Navi Mumbai, Maharashtra, India
    Biomed Pharmacother 66:617-26. 2012
    ..b>Pentoxifylline (PTX), a non-specific phosphodiesterase inhibitor, has shown to have radiosensitizing properties for a variety ..
  24. ncbi Radiation-induced enteropathy: molecular basis of pentoxifylline-vitamin E anti-fibrotic effect involved TGF-β1 cascade inhibition
    Saad Hamama
    Molecular Radiotherapy, Universite Paris Sud XI, Le Kremlin Bicetre, France
    Radiother Oncol 105:305-12. 2012
    Radiation-induced fibrosis is a serious late complication of radiotherapy. Pentoxifylline-vitamin E has proven effective and safe in clinical trials in the treatment of fibrosis, while the molecular mechanism of its activity is yet ..
  25. ncbi Periungual leishmaniasis
    Ciro Martins Gomes
    University Hospital of Brasilia, University of Brasilia, DF, Brazil
    An Bras Dermatol 87:148-9. 2012
    ..failed to respond to treatment with antimony, but achieved clinical cure after this was associated with pentoxifylline. The case highlights the rarity of the periungual location of the leishmanial lesion and the difficulties ..
  26. ncbi Preventive effect of pentoxifylline on renal scarring in rat model of pyelonephritis
    Aydin Yagmurlu
    Department of Pediatric Surgery, University of Ankara School of Medicine, Ankara, Turkey
    Urology 61:1037-41. 2003
    To evaluate the efficiency of pentoxifylline (PTX), a methyl xanthine derivative, in preventing renal scar formation after the induction of pyelonephritis in an experimental rat model with delayed antimicrobial therapy.
  27. pmc Pentoxifylline in hepatopulmonary syndrome
    Hamid Reza Kianifar
    Allergy Research Center, Ghaem Medical Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
    World J Gastroenterol 18:4912-6. 2012
    To determine the effects of pentoxifylline (PTX) on clinical manifestations and evaluate arterial blood gas data in hepatopulmonary syndrome (HPS) in children.
  28. pmc Effect of pentoxifylline on preventing acute kidney injury after cardiac surgery by measuring urinary neutrophil gelatinase - associated lipocalin
    Khosro Barkhordari
    Department of Anesthesiology and Critical Care, Tehran Heart Center, Tehran University of Medical Sciences, Iran
    J Cardiothorac Surg 6:8. 2011
    ..b>Pentoxifylline (PTX), a non-specific phosphodiesterase inhibitor, can suppress the production of some factors of inflammatory ..
  29. ncbi Pretreatment with pentoxifylline has antidepressant-like effects in a rat model of acute myocardial infarction
    Thierno Madjou Bah
    Biomedecine Center, Hôpital Sacré Cœur of Montréal, Quebec, Canada
    Behav Pharmacol 22:779-84. 2011
    ..that, after myocardial infarction (MI), rats display apoptosis in the limbic system that can be prevented by pentoxifylline (PTX), a proinflammatory cytokine inhibitor...
  30. ncbi Pentoxifylline alleviates vascular impairment in insulin resistance via TNF-α inhibition
    Hany M El-Bassossy
    Hypertension and Vascular Center, Wake Forest University Baptist Medical Center, Winston Salem, NC, 27157, USA
    Naunyn Schmiedebergs Arch Pharmacol 384:277-85. 2011
    Deterioration of vascular reactivity plays a pivotal role in vascular complications. Pentoxifylline (PTX) is a well-tolerated drug used to treat vascular insufficiency...
  31. ncbi Pentoxifylline ameliorates lithium-pilocarpine induced status epilepticus in young rats
    Mohammad Tariq
    Neuroscience Research Group, Research Center, Riyadh Military Hospital, W 912, PO Box 7897, Riyadh 11159, Saudi Arabia
    Epilepsy Behav 12:354-65. 2008
    The neuroprotective effects of pentoxifylline (PTX) against lithium-pilocarpine (Li-Pc)-induced status epilepticus (SE) in young rats are described...
  32. ncbi Pentoxifylline inhibits melanoma tumor growth and angiogenesis by targeting STAT3 signaling pathway
    Mohammad Zahid Kamran
    Gude Lab, Advanced Centre for Treatment, Research and Education in Cancer ACTREC, Tata Memorial Centre, Kharghar, Navi Mumbai 410210, Maharastra, India
    Biomed Pharmacother 67:399-405. 2013
    b>Pentoxifylline (PTX), a phosphodiesterase inhibitor, has been shown to have anti-metastatic or anti-angiogenic activity against many human cancers. However, the underlying mechanisms are unknown...
  33. pmc Systematic review on the treatment of pentoxifylline in patients with non-alcoholic fatty liver disease
    Wenjun Li
    Department of Endocrinology, Shanghai Tenth People s Hospital, Tongji University School of Medicine, Shanghai 200072, China
    Lipids Health Dis 10:49. 2011
    As an anti-TNF agent that targets inflammatory process directly, Pentoxifylline has been investigated for treatment of NASH in individual studies and pilot trials for years...
  34. ncbi Effects of pentoxifylline treatment before freezing on motility, viability and acrosome status of poor quality human spermatozoa cryopreserved by the liquid nitrogen vapor method
    S C Esteves
    Laboratório de Reprodução Humana, Disciplina de Urologia, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
    Braz J Med Biol Res 40:985-92. 2007
    The objective of the present study was to investigate the effects of the direct addition of pentoxifylline (PF) to the ejaculates of men with poor sperm quality before freezing on post-thaw sperm motility, viability, acrosome integrity, ..
  35. ncbi Pentoxifylline modulates intracellular signalling of TGF-beta in cultured human peritoneal mesothelial cells: implications for prevention of encapsulating peritoneal sclerosis
    Kuan Yu Hung
    Department of Internal Medicine, Far Eastern Memorial Hospital, Pan Chiao, Taiwan, ROC
    Nephrol Dial Transplant 18:670-6. 2003
    ..reported previously that TGF-beta stimulates collagen gene expression in cultured HPMC, and is attenuated by pentoxifylline (PTX)...
  36. ncbi Effects of pentoxifylline on cytokine profiles and left ventricular performance in patients with decompensated congestive heart failure secondary to idiopathic dilated cardiomyopathy
    Karen Sliwa
    Heart Failure Research Unit, Department of Cardiology, Chris Hani Baragwanath Hospital, University of the Witwatersrand, P O Bertsham, 2013 Johannesburg, South Africa
    Am J Cardiol 90:1118-22. 2002
    ..Although pentoxifylline, an immunomodulatory agent that inhibits tumour necrosis factor-alpha (TNF-alpha) production, improves pump ..
  37. pmc Pentoxifylline attenuates nociceptive sensitization and cytokine expression in a tibia fracture rat model of complex regional pain syndrome
    Tzuping Wei
    Physical Medicine and Rehabilitation Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Eur J Pain 13:253-62. 2009
    ....
  38. ncbi Effects of pentoxifylline on peritoneal fibroblasts and silica-induced peritoneal fibrosis
    Cheng Chung Fang
    Department of Emergency Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China
    Perit Dial Int 23:228-36. 2003
    ..Up to now, the treatment of peritoneal fibrosis in patients with CAPD remains unsatisfactory. Pentoxifylline (PTX) is a xanthine derivative and is used in the treatment of peripheral vascular and cerebrovascular ..
  39. ncbi Pentoxifylline modulates cell surface integrin expression and integrin mediated adhesion of B16F10 cells to extracellular matrix components
    Aparna Ratheesh
    Gude Lab, Cancer Research Institute, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, India
    Cancer Biol Ther 6:1743-52. 2007
    Our previous studies demonstrated that Pentoxifylline (PTX), a phosphodiesterase inhibitor, could inhibit the lung homing of B16-F10 melanoma cells in C57BL/6 mice...
  40. ncbi Pentoxifylline and antioxidants improve sperm quality in male patients with varicocele
    Alejandro Oliva
    Unidad de Andrologia, Servicio de Urologia, Hospital Italiano de Rosario, Rosario, Argentina
    Fertil Steril 91:1536-9. 2009
    We examined the effect of 12 weeks of daily oral administration of pentoxifylline with zinc and folic acid on the semen quality of 36 men with varicocele-associated infertility in an open, uncontrolled study...
  41. pmc Pentoxifylline modulates intestinal tight junction signaling after burn injury: effects on myosin light chain kinase
    Todd W Costantini
    Department of Surgery, Division of Trauma, Surgical Critical Care, and Burns, University of California, San Diego School of Medicine, San Diego, California 92103 8896, USA
    J Trauma 66:17-24; discussion 24-5. 2009
    ..We have previously shown that pentoxifylline (PTX) decreases both TNF-alpha synthesis and NF-kappaB activation in models of shock...
  42. ncbi C60 fullerene-pentoxifylline dyad nanoparticles enhance autophagy to avoid cytotoxic effects caused by the β-amyloid peptide
    Chi Ming Lee
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Nanomedicine 7:107-14. 2011
    ..In this study, PEG-C(60)-3, a C(60) fullerene derivative incorporating poly(ethylene glycol), and its pentoxifylline-bearing hybrid (PTX-C(60)-2) were investigated against β-amyloid (Aβ)(25-35)-induced toxicity toward Neuro-..
  43. ncbi Pentoxifylline attenuates tubulointerstitial fibrosis by blocking Smad3/4-activated transcription and profibrogenic effects of connective tissue growth factor
    Shuei Liong Lin
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    J Am Soc Nephrol 16:2702-13. 2005
    b>Pentoxifylline (PTX) is a potent inhibitor of connective tissue growth factor (CTGF), but its underlying mechanism is poorly understood...
  44. ncbi Combined itraconazole-pentoxifylline treatment promptly reduces lung fibrosis induced by chronic pulmonary paracoccidioidomycosis in mice
    Tonny W Naranjo
    Unidad de Micología Médica y Experimental, Corporacion para Investigaciones Biologicas, Medellin, Colombia
    Pulm Pharmacol Ther 24:81-91. 2011
    ..In this study, was propose the pentoxifylline as complementary treatment in the pulmonary PCM due to its immunomodulatory and anti-fibrotic properties ..
  45. ncbi Pentoxifylline prevents spontaneous brain ischemia in stroke-prone rats
    Cristina Banfi
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    J Pharmacol Exp Ther 310:890-5. 2004
    Anti-inflammatory properties of pentoxifylline (PTX) have recently been described...
  46. ncbi Multiple pathological events in exercised dystrophic mdx mice are targeted by pentoxifylline: outcome of a large array of in vivo and ex vivo tests
    Rosa Burdi
    Unit of Pharmacology, Department of Pharmaco Biology, Faculty of Pharmacy, University of Bari, Bari, Italy
    J Appl Physiol (1985) 106:1311-24. 2009
    The phosphodiesterases inhibitor pentoxifylline gained attention for Duchenne muscular dystrophy therapy for its claimed anti-inflammatory, antioxidant, and antifibrotic action...
  47. ncbi Therapeutic options in non-alcoholic steatohepatitis (NASH). Are all agents alike? Results of a preliminary study
    Eugen Florin Georgescu
    Department of Internal Medicine 2, Filantropia University Hospital, Str Constantin Brancusi 3, 200136 Craiova, Romania
    J Gastrointestin Liver Dis 16:39-46. 2007
    The evaluation of the efficacy of ursodeoxycholic acid (UDCA), pentoxifylline, losartan, and atorvastatin in non-alcoholic steatohepatitis (NASH) treatment.
  48. ncbi Immunomodulatory properties of pentoxifylline are mediated via adenosine-dependent pathways
    Simone Kreth
    Department of Anaesthesiology, Ludwig Maximilians University, Munich, Germany
    Shock 34:10-6. 2010
    The phosphodiesterase inhibitor pentoxifylline (PTX) exerts multiple beneficial immunomodulatory effects in states of hyperinflammation...
  49. pmc Pentoxifylline downregulates profibrogenic cytokines and procollagen I expression in rat secondary biliary fibrosis
    C Raetsch
    Department of Gastroenterology, University Hospital Benjamin Franklin, Free University of Berlin, Germany
    Gut 50:241-7. 2002
    The trisubstituted methylxanthine derivative pentoxifylline inhibits hepatic stellate cell proliferation and collagen synthesis in vitro...
  50. ncbi Pentoxifylline attenuated the renal disease progression in rats with remnant kidney
    Shuei Liong Lin
    Department of Internal Medicine, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei, Taiwan
    J Am Soc Nephrol 13:2916-29. 2002
    Previous studies have reported that pentoxifylline, a phosphodiesterase inhibitor, attenuates experimental mesangial proliferative glomerulonephritis...
  51. ncbi Renal pro-inflammatory cytokine gene expression in diabetic nephropathy: effect of angiotensin-converting enzyme inhibition and pentoxifylline administration
    Juan F Navarro
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
    Am J Nephrol 26:562-70. 2006
    ..In addition, we also investigated the effect of angiotensin-converting enzyme inhibition and pentoxifylline (PTF) administration on these parameters.
  52. ncbi Suppression of experimental systemic lupus erythematosus (SLE) in mice via TNF inhibition by an anti-TNFalpha monoclonal antibody and by pentoxiphylline
    R Segal
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Lupus 10:23-31. 2001
    ..Abrogation of TNFalpha and IL-1 production in the early stages of experimental SLE by an anti-TNFalpha mAb or by PTX improves the clinical status of mice afflicted with this autoimmune disease...
  53. ncbi Prophylactic effect of pentoxifylline on radiotherapy complications: a clinical study
    Erdinc Aygenc
    Department of Otorhinolaryngology Head and Neck Surgery, Department of Numune Research and Educational Hospital, Ankara, Turkey
    Otolaryngol Head Neck Surg 130:351-6. 2004
    The purpose of this study was to assess the prophylactic effect of pentoxifylline (Ptx) on complications related to radiation.
  54. ncbi Pentoxifylline attenuates TNF-α protein levels and brain edema following temporary focal cerebral ischemia in rats
    Abedin Vakili
    Department and Research Center of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
    Brain Res 1377:119-25. 2011
    ..To further investigate whether TNF-α would play a role in brain edema formation, we examined the effects of pentoxifylline (PTX, an inhibitor of TNF-α synthesis) on the brain edema and TNF-α levels in a model of transient focal ..
  55. ncbi Role of cytokines (TNF-alpha, IL-1beta and KC) in the pathogenesis of CPT-11-induced intestinal mucositis in mice: effect of pentoxifylline and thalidomide
    Maria Luisa P Melo
    Department of Physiology, Faculty of Medicine, Federal University of Ceara, Rua Cel Nunes de Melo, 1127, CEP 60 430 270 Fortaleza, CE, Brazil
    Cancer Chemother Pharmacol 61:775-84. 2008
    ..A major toxic effect of CPT-11 is delayed diarrhea; however, the exact mechanism by which the drug induces diarrhea has not been established...
  56. ncbi Pentoxifylline for treatment of venous leg ulcers: a systematic review
    Andrew Jull
    Centre for Evidence Based Nursing Aotearoa, Auckland Hospital, Auckland, New Zealand
    Lancet 359:1550-4. 2002
    ..We did a systematic review of randomised controlled trials that compared pentoxifylline (with and without compression treatment) with placebo, or other treatments, in patients with venous leg ulcers.
  57. ncbi Double-blind placebo-controlled trial of pentoxifylline added to risperidone: effects on aberrant behavior in children with autism
    Shahin Akhondzadeh
    Psychiatric Research Centre, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, South Kargar Street, Tehran 13337, Iran
    Prog Neuropsychopharmacol Biol Psychiatry 34:32-6. 2010
    ..The objective of this study was to access the effects of pentoxifylline plus risperidone in the treatment of autistic disorder.
  58. ncbi Pentoxifylline reduces biochemical markers of ischemia-reperfusion induced spinal cord injury in rabbits
    S Savas
    Department of Physical Medicine and Rehabilitation, Suleyman Demirel University Medical School, Isparta, Turkey
    Spinal Cord 40:224-9. 2002
    Occlusion of the infrarenal abdominal aorta with administration of pentoxifylline was applied to adult rabbits, followed by removal of aortic clamp and reperfusion...
  59. ncbi Pentoxifylline after conservative surgery for endometriosis: a randomized, controlled trial
    Huse Kamencic
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Minim Invasive Gynecol 15:62-6. 2008
    To compare outcomes after conservative surgery for endometriosis with and without pentoxifylline and to assess the efficacy of pentoxifylline in preventing recurrence of endometriosis after conservative surgery.
  60. ncbi Influence of pentoxifylline and interferon-alpha on prevention of stricture due to corrosive esophagitis. An experimental study in the rat
    B B Apaydin
    Department of Surgery, Cerrahpasa Medical Faculty of Istanbul University, Istanbul, Turkey
    Eur Surg Res 33:225-31. 2001
    The effects of pentoxifylline (PTX) and interferon alpha (IFN-alpha) in the prevention of strictures due to corrosive esophagitis in rats were investigated. Forty rats were randomly divided into four equal groups...
  61. pmc Pentoxifylline aggravates fatty liver in obese and diabetic ob/ob mice by increasing intestinal glucose absorption and activating hepatic lipogenesis
    J Massart
    INSERM, U991, Universite de Rennes 1, Rennes, France
    Br J Pharmacol 165:1361-74. 2012
    b>Pentoxifylline is in clinical trials for non-alcoholic fatty liver disease and diabetic nephropathy. Metabolic and hepatic effects of pentoxifylline were assessed in a murine model of obesity and type 2 diabetes.
  62. ncbi Unravelling the antimetastatic potential of pentoxifylline, a methylxanthine derivative in human MDA-MB-231 breast cancer cells
    Peeyush N Goel
    Gude Lab, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India
    Mol Cell Biochem 358:141-51. 2011
    b>Pentoxifylline (PTX), a methylxanthine derivative is a non-steroidal immunomodulating agent with unique hemorheologic properties...
  63. ncbi The use of pentoxifylline as adjuvant therapy with praziquantel downregulates profibrogenic cytokines, collagen deposition and oxidative stress in experimental schistosomiasis mansoni
    Naglaa El-Lakkany
    Pharmacology Department, Theodor Bilharz Research Institute, Warrak el Hadar, Imbaba, P O Box 30, Giza 12411, Egypt
    Exp Parasitol 129:152-7. 2011
    This study investigates the possible use of pentoxifylline (PTX), with antifibrotic and anti-inflammatory properties, as adjuvant in treatment of schistosomal liver fibrosis through determination of some profibrogenic cytokines, oxidative ..
  64. ncbi Effects of pentoxifylline on inflammatory parameters in chronic kidney disease patients: a randomized trial
    Marian Goicoechea
    Nephrology Unit, University Hospital Gregorio Maranon, Madrid, Spain
    J Nephrol 25:969-75. 2012
    b>Pentoxifylline (PTF) is a potential therapeutic agent in chronic kidney disease due to its antiinflammatory and antiproteinuric effects that may influence the progression of renal disease.
  65. ncbi Pentoxifylline and prevention of hyperoxia-induced lung -injury in neonatal rats
    Beatriz Almario
    Department of Pediatrics, Batchelor Children s Research Institute, University of Miami Miller School of Medicine, Miami, Florida, USA
    Pediatr Res 71:583-9. 2012
    ..The phosphodiesterase inhibitor pentoxifylline (PTX) has anti-inflammatory and antifibrotic effects in multiple organs...
  66. ncbi The efficacy of pentoxifylline in the treatment of vascular dementia: a systematic review
    Michael C Sha
    Division of General Internal Medicine and Geriatrics, Indiana University School of Medicine, Indianapolis, USA
    Alzheimer Dis Assoc Disord 17:46-54. 2003
    This systematic review seeks to (1) summarize the pharmacologic effects of pentoxifylline on the cerebrovasculature and (2) review critically the studies evaluating pentoxifylline in the treatment of vascular dementia...
  67. ncbi Systematic review: pentoxifylline for the treatment of severe alcoholic hepatitis
    R Parker
    NIHR Centre for Liver Research and Biomedical Research Unit, University of Birmingham, Birmingham, UK
    Aliment Pharmacol Ther 37:845-54. 2013
    Acute alcoholic hepatitis (AH) is a severe manifestation of alcoholic liver disease with a grave prognosis. Pentoxifylline, an oral antitumour necrosis factor agent, has been reported to reduce mortality and incidence of hepatorenal ..
  68. ncbi American cutaneous leishmaniasis unresponsive to antimonial drugs: successful treatment using combination of N-methilglucamine antimoniate plus pentoxifylline
    Andre Bafica
    Faculdade de Medicina da Universidade Federal da Bahia, Brazil
    Int J Dermatol 42:203-7. 2003
    ..Cytokines, among other factors, have been shown to influence lesion development and tumoral necrosis factor-alpha is a major cytokine implicated in pathogenesis of ulcers...
  69. ncbi Additive antiproteinuric effect of pentoxifylline in patients with type 2 diabetes under angiotensin II receptor blockade: a short-term, randomized, controlled trial
    Juan F Navarro
    Servicio de Nefrologia, Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Tenerife 38010, Spain
    J Am Soc Nephrol 16:2119-26. 2005
    ..This study tested the hypothesis that the combination of pentoxifylline (PTF) with angiotensin II receptor blockers in normotensive patients with type 2 diabetes produces an additive ..
  70. ncbi Potentiation of antimetastatic activity of pentoxifylline in B16F10 and B16F1 melanoma cells through inhibition of glutathione content
    Vivek Shukla
    Chemotherapy Division, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai, India
    Cancer Biother Radiopharm 18:559-64. 2003
    The aim of this work is to evaluate the antioxidative activity of antimetastatic agent pentoxifylline (PTX) in B16F10 and B16F1 melanoma cells.
  71. ncbi Treatment of vascular inner ear disease in vascular patients with pentoxifylline: a controlled, randomized trial
    M R Cesarone
    Department of Biomedical Sciences, Chieti University and San Valentino Vascular Screening Project, PE, Italy
    Angiology 53:S23-6. 2002
    The efficacy of Pentoxifylline in vascular inner ear disease (VIED) was studied comparing PXF and placebo in a 4-week study; 40 patients with vascular disease and monolateral loss of hearing, vertigo, dizziness, tinnitus (analyzed with an ..
  72. ncbi Prevention of hepatopulmonary syndrome and hyperdynamic state by pentoxifylline in cirrhotic rats
    B Sztrymf
    Laboratoire de Chirurgie Experimentale, Unité Propre de Recherche de l Enseignement Supérieur Equipe d Accueil 2705, Centre Chirurgical Marie Lannelongue, Universite Paris Sud, Paris, France
    Eur Respir J 23:752-8. 2004
    ..TNF-alpha was inhibited by 5 weeks of pentoxifylline (10 mg x kg body weigh(-1) x day(-1)) in rats with cirrhosis induced by common bile duct ligation...
  73. ncbi Effect of pentoxifylline on proteinuria, markers of tubular injury and oxidative stress in non-diabetic patients with chronic kidney disease - placebo controlled, randomized, cross-over study
    Marcin Renke
    Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Acta Biochim Pol 57:119-23. 2010
    ..However, there is no universal therapy that can stop progression of CKD. Pentoxifylline (PTE) is a non-specific phosphodiesterase inhibitor with anti-inflammatory properties...
  74. ncbi May pentoxifylline improve lung function after one-lung flooding?
    S Klinzing
    Klinik für Anästhesiologie und Intensivtherapie, Friedrich Schiller Universitat Jena, Germany
    Res Exp Med (Berl) 200:69-76. 2001
    ..A study was made on four animals to determine whether administration of pentoxifylline--a potent inhibitor of granulocyte adhesion to the endothelium--improves lung function after one-lung flooding...
  75. ncbi Combination therapy including pentoxifylline for entero-Behçet's disease
    T Hisamatsu
    Department of Internal Medicine, Ichikawa General Hospital, Tokyo Dental College, 5-11-13, Sugano, Ichikawa, Chiba 272-8513, Japan
    Bull Tokyo Dent Coll 42:169-76. 2001
    ..We utilized a combination therapy including 600 mg of pentoxifylline per day, in two doses, to treat three female patients and observed the subsequent changes in clinical symptoms,..
  76. ncbi Pentoxifylline inhibits integrin-mediated adherence of 12(S)-HETE and TNFalpha-activated B16F10 cells to fibronectin and endothelial cells
    Meenakashi Jain
    Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India
    Chemotherapy 56:82-8. 2010
    b>Pentoxifylline (PTX), a phosphodiesterase inhibitor, inhibits homing of metastatic B16F10 melanoma cells to the lung...
  77. ncbi Pentoxifylline therapy after laparoscopic surgery for different stages of endometriosis: a prospective, double-blind, randomized, placebo-controlled study
    Saeed Alborzi
    Division of Infertility and Endoscopic Surgery, Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
    J Minim Invasive Gynecol 14:54-8. 2007
    To evaluate the effects of pentoxifylline administration on patients with different stages of endometriosis on whom laparoscopy was performed.
  78. ncbi Attenuation of morphine tolerance by minocycline and pentoxifylline in naive and neuropathic mice
    Joanna Mika
    Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Brain Behav Immun 23:75-84. 2009
    ..This study explores the effects of two glial activation inhibitors, minocycline and pentoxifylline, on the development of tolerance to morphine in naive and chronic constriction injury (CCI)-exposed mice...
  79. ncbi Pentoxifylline for diabetic kidney disease
    Dan Shan
    Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
    Cochrane Database Syst Rev 2:CD006800. 2012
    ..b>Pentoxifylline is a methylxanthine phosphodiesterase inhibitor with favourable anti-inflammatory effects and immunoregulatory ..
  80. ncbi The effect of pentoxifylline on ultrastructure and antioxidant potential during cyclophosphamide-induced liver injury
    M Sulkowska
    Department of Pathological Anatomy, Medical University of Bialystok, Poland
    J Submicrosc Cytol Pathol 31:413-22. 1999
    The aim of this study was to evaluate the effect of pentoxifylline (PTXF) (30 mg/kg b.w. for 10 days) on the antioxidant potential in the rat liver after single intraperitoneal (i.p.) cyclophosphamide (CP) administration (150 mg/kg b.w...
  81. ncbi Alleviation of mutagenic effects of polycyclic aromatic agents (quinacrine mustard, ICR-191 and ICR-170) by caffeine and pentoxifylline
    Jacek Piosik
    Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Kladki 24, 80 822 Gdansk, Poland
    Mutat Res 530:47-57. 2003
    ..Here we demonstrate that caffeine and another xanthine, pentoxifylline (PTX), effectively alleviate mutagenic action of polycyclic aromatic agents (exemplified by quinacrine mustard ..
  82. ncbi Preservation of peritoneal morphology and function by pentoxifylline in a rat model of peritoneal dialysis: molecular studies
    Kuan Yu Hung
    Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
    Nephrol Dial Transplant 23:3831-40. 2008
    High-glucose (HG) content of dialysate accelerated peritoneal fibrosis. We investigated in vitro mechanisms and the in vivo potential of pentoxifylline (PTX) to prevent this fibrogenic process.
  83. ncbi Pentoxifylline improves circulatory failure and survival in murine models of endotoxaemia
    C C Wu
    Department of Pharmacology, National Defense Medical Centre, Taipei, Taiwan
    Eur J Pharmacol 373:41-9. 1999
    b>Pentoxifylline, a methylxanthine derivative, has been widely used to improve erythrocyte deformability and capillary blood circulation in patients with claudication and cerebrovascular disorders as well as in animals with sepsis...
  84. ncbi Effects of the non-selective phosphodiesterase inhibitor pentoxifylline on regional cerebral blood flow and large arteries in healthy subjects
    C Kruuse
    Department of Neurology, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup Copenhagen, Denmark
    Eur J Neurol 7:629-38. 2000
    The vasodilating properties of the non-selective phosphodiesterase (PDE) inhibitor pentoxifylline were evaluated. Pentoxifylline has been reported to increase cerebral blood flow (CBF) and improve recovery rate of stroke patients...
  85. ncbi Pharmacodynamics of pentoxifylline and/or praziquantel in murine schistosomiasis mansoni
    Naglaa El-Lakkany
    Department of Pharmacology, Theodor Bilharz Research Institute, Guiza, Egypt
    APMIS 115:184-94. 2007
    b>Pentoxifylline (PTX) was proved to exert both anti-inflammatory and anti-fibrotic effects, and was used therapeutically in this experimental model to investigate its role alone or with praziquantel (PZQ) in Schistosoma mansoni-infected ..
  86. ncbi Severe ischemia of the glans penis following circumcision: a successful treatment via pentoxifylline
    Adnan Aslan
    Akdeniz University School of Medicine, Department of Pediatric Surgery, Antalya, Turkey
    Int J Urol 12:705-7. 2005
    ..This was successfully treated with pentoxifylline injection for 5 days, and while the black color of the glans penis changed to brownish at 48 h, appearances ..
  87. ncbi Pentoxifylline is as effective as captopril in the reduction of microalbuminuria in non-hypertensive type 2 diabetic patients--a randomized, equivalent trial
    M Rodriguez-Moran
    Medical Research Unit in Clinical Epidemiology of the Mexican Social Security Institute, and Research Group on Diabetes and Chronic Illnesses, Durango, Mexico
    Clin Nephrol 64:91-7. 2005
    To compare the efficacy of pentoxifylline and captopril on urinary albumin excretion (UAE) rate in non-hypertensive diabetic patients with microalbuminuria.
  88. ncbi Pentoxifylline fails to attenuate fibrosis in dystrophic (mdx) diaphragm muscle
    Luc E Gosselin
    Department of Exercise and Nutrition Sciences, 405 Kimball Tower, University at Buffalo, Buffalo, New York 14214, USA
    Muscle Nerve 33:820-3. 2006
    ..The purpose of this study was to determine whether pentoxifylline (PTX) treatment for 4 weeks (16 mg/kg/day) could significantly attenuate the process of fibrosis in diaphragm ..
  89. ncbi Inhibition of tumor necrosis factor alpha gene transcription by pentoxifylline reduces normothermic liver ischemia-reperfusion injury in rats
    A El-Ghoneimi
    Laboratoire de Recherches Chirurgicales, IFR 50, Faculte de Medecine, Universite de Nice Sophia Antipolis, Nice, France
    Transplant Proc 39:1761-4. 2007
    b>Pentoxifylline (PTX) has been shown to protect the liver against normothermic ischemia-reperfusion (I-R) injury...
  90. ncbi [Malignant atrophic papulosis (Köhlmeier-Degos disease). Failure to respond to interferon alpha-2a, pentoxifylline and aspirin]
    B Melnik
    Dermatologie, Umweltmedizin und Gesundheitstheorie, Universitat Osnabruck, Germany
    Hautarzt 53:618-21. 2002
    ..Furthermore, we could not confirm the effectiveness of a recently reported treatment modality with pentoxifylline and aspirin administered to our patient over a period of 5 months.
  91. ncbi Pentoxifylline modifies three-dimensional collagen lattice model contraction and expression of collagen types I and III by human fibroblasts derived from post-burn hypertrophic scars and from normal skin
    Cesar Isaac
    Faculty of Medicine, Cell Culture and Wound Healing Research Laboratory, Division of Plastic Surgery, University of Sao Paulo, Avenida Doutor Arnaldo 455 sala 1360, Sao Paulo, Sao Paulo, Brazil
    Burns 35:701-6. 2009
    ..model we subjected hypertrophic scar and non-cicatricial fibroblasts to the antifibrogenic agent pentoxifylline (PTF - 1mg/mL) in order to reduce proliferation, collagen types I and III synthesis and model contraction...
  92. ncbi In vitro antioxidant properties of pentoxifylline, piracetam, and vinpocetine
    Beata Horvath
    First Department of Medicine, Division of Cardiology, University of Pecs School of Medicine, Pecs, Hungary
    Clin Neuropharmacol 25:37-42. 2002
    ....
  93. ncbi Effects of pentoxifylline on the hepatic content of TGF-beta1 and collagen in Schistosomiasis japonica mice with liver fibrosis
    Li juan Xiong
    Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
    World J Gastroenterol 9:152-4. 2003
    To study the effects of pentoxifylline (PTX) on the content of hepatic TGF-beta1, type I and type III collagen in schistosomiasis japonica mice with liver fibrosis and its mechanism of anti-fibrosis.
  94. ncbi Pentoxifylline treatment improves neurological and neurochemical deficits in rats subjected to transient brain ischemia
    Renata de Barros Bruno
    Department of Biophysiology and Pharmacology, Faculty of Medicine of Juazeiro do Norte FMJ, Av Tenente Raimundo Rocha s n, Juazeiro do Norte, 63040 000, Brazil
    Brain Res 1260:55-64. 2009
    The possible neuroprotector effects of pentoxifylline (P), a methylxanthine derivative and phosphodiesterase inhibitor, were studied on male Wistar rats subjected to a model of transient brain ischemia...
  95. ncbi A comparison of heat-induced hyperactivation in patients' sperm after colloid or pentoxifylline wash methods
    V L Miller
    Department of Gynecology and Obstetrics, Loma Linda University School of Medicine, California 92350, USA
    Am J Obstet Gynecol 184:1057-9. 2001
    ..STUDY DESIGN: Sperm specimens (N = 169 cases) were washed by either colloid or pentoxifylline wash methods, and the motility parameters were measured at either 37 degrees C or 40 degrees C at baseline (0 ..
  96. ncbi Antioxidant and radical scavenging properties of 8-oxo derivatives of xanthine drugs pentoxifylline and lisofylline
    V B Bhat
    Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India
    Biochem Biophys Res Commun 288:1212-7. 2001
    The antioxidant and radical scavenging properties of 8-oxo derivatives of pentoxifylline, lisofylline, enprofylline (3-propyl xanthine), and 1,7-dimethyl enprofylline were studied in vitro...
  97. pmc Inhibition of tubulointerstitial fibrosis by pentoxifylline is associated with improvement of vascular endothelial growth factor expression
    Qiu Gen Zhou
    Division of Nephrology, Southern Medical University Nanfang Hospital, Guangzhou 510515, China
    Acta Pharmacol Sin 30:98-106. 2009
    Recent information indicates that pentoxifylline (PTX) has the ability to suppress inflammation and profibrotic cell proliferation...
  98. pmc Inhibition of homologous recombination repair with Pentoxifylline targets G2 cells generated by radiotherapy and induces major enhancements of the toxicity of cisplatin and melphalan given after irradiation
    Lothar Bohm
    Department of Pharmacology, University of Pretoria P O Box 2034, Pretoria 0001, South Africa
    Radiat Oncol 1:12. 2006
    The presentation reviews the modus operandi of the dose modifying drug Pentoxifylline and the dose enhancement factors which can be achieved in different cell types...
  99. ncbi The effects of pentoxifylline on the myocardial inflammation and ischemia-reperfusion injury during cardiopulmonary bypass
    Hasim Ustunsoy
    Department of Cardiovascular Surgery, Gaziantep University Medical Faculty, Gaziantep, Turkey
    J Card Surg 21:57-61. 2006
    b>Pentoxifylline (Ptx) decreases necessity of cell energy and inflammatory reactions via inhibition of 5'-nucleotidase (5'-NT)...
  100. ncbi The cerebroprotective effects of pentoxifylline and aprotinin during cardiopulmonary bypass in dogs
    Kadir Durgut
    Department of Cardiovascular Surgery, Meram School of Medicine, University of Selcuk, Konya, Turkey
    Perfusion 19:101-6. 2004
    The purpose of this study was to investigate the cerebroprotective effects of pentoxifylline (PNX) and aprotinin in dogs using cardiopulmonary bypass (CPB).
  101. pmc Steroid-sparing effects of pentoxifylline in pulmonary sarcoidosis
    M K Park
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1434, USA
    Sarcoidosis Vasc Diffuse Lung Dis 26:121-31. 2009
    ..Agents that target pro-inflammatory cytokines may be useful in pulmonary sarcoidosis...

Research Grants62

  1. Resuscitation Outcomes Consortium (ROC) Regional Clinical Center-Seattle-King
    PETER JAMES KUDENCHUK; Fiscal Year: 2013
    ..injury, 2) intravenous estrogen to decrease the magnitude of reperfusion injury, and 3) intravenous pentoxifylline to reduce release of inflammatory mediators and reactive oxidants after reperfusion...
  2. Resuscitation Outcomes Consortium (ROC) Regional Clinical Centers-Milwaukee
    TOM PAUL AUFDERHEIDE; Fiscal Year: 2013
    ..injury, 2) intravenous estrogen to decrease the magnitude of reperfusion injury, and 3) intravenous pentoxifylline to reduce release of inflammatory mediators and reactive oxidants after reperfusion...
  3. Resuscitation Outcomes Consortium (ROC) Regional Clinical Center-Pittsburgh
    Clifton W Callaway; Fiscal Year: 2013
    ..injury, 2) intravenous estrogen to decrease the magnitude of reperfusion injury, and 3) intravenous pentoxifylline to reduce release of inflammatory mediators and reactive oxidants after reperfusion...
  4. Novel therapies in alcoholic hepatitis University of Louisville
    Craig J McClain; Fiscal Year: 2013
    ..The most widely-used (off-label) drug therapies for AH are glucocorticoids and pentoxifylline. Both agents have anti-inflammatory activities and downregulate proinflammatory cytokines such as tumor ..
  5. Obesity and Pancreatic Cancer: The Role of IGF-1
    Susan M Fischer; Fiscal Year: 2012
    ..To determine the importance of cytokines to pancreatic tumorigenesis, an inhibitor of cytokine synthesis, pentoxifylline, will be administered to K5.COX-2 mice on CR, normal or obesity-inducing diets...
  6. Novel Therapies for Alcoholic Hepatitis
    Gyongyi Szabo; Fiscal Year: 2013
    ..The most commonly used off-label drugs for AH are corticosteroids and pentoxifylline. Unfortunately, even patients with AH treated with corticosteroids have a 6 month mortality of 40%...
  7. PAIN EVOKED RELEASE OF AMINO ACIDS AND PROSTANOIDS
    Tony L Yaksh; Fiscal Year: 2012
    ..3) Given the role of microglia, spinal blockade of activation using agents such as minocycline or pentoxifylline will block: P38 activation, evoked release of spinal PG, COX2 upregulation and hyperalgesia...
  8. Clincal Research Network in Non-Alcoholic Steatohepatitis (NASH CRN)
    Arthur Joseph McCullough; Fiscal Year: 2013
    ..the specific aims stated above and additionally conduct 2 clinical trials using S adenosyl L-methionine and pentoxifylline, based on sound pathophysiological rationale developed during the initial funding period...
  9. Gut Microbiota and Atherosclerosis in ESRD
    DOMINIC S RAJ; Fiscal Year: 2013
    ..b>Pentoxifylline (PTX) blocks cytokine generation in response to endotoxemia at the tissue level, and hence complements the ..
  10. HIV, Inflammation, and Endothelial Dysfunction
    Samir Kumar Gupta; Fiscal Year: 2012
    ..Our novel preliminary data suggest that the anti-inflammatory drug pentoxifylline (PTX) may significantly improve flow-mediated dilation of the brachial artery, an in vivo measure of ..
  11. Resuscitation Outcomes Consortium (ROC) Regional Clinical Center-Toronto Regional
    Laurie Morrison; Fiscal Year: 2013
    ..injury, 2) intravenous estrogen to decrease the magnitude of reperfusion injury, and 3) intravenous pentoxifylline to reduce release of inflammatory mediators and reactive oxidants after reperfusion...
  12. Peptide Vaccine for Experimental Autoimmune Myocarditis
    Daniel Zimmerman; Fiscal Year: 2003
    ..Other recent reports also have show a role for IL-10 in disease control in EAM, including use of pentoxifylline which was reported as being used in the human condition...
  13. NUTRITION AND DRUGS REDUCE PROTEIN LOSS IN SEPSIS
    ROLAND DICKERSON; Fiscal Year: 1992
    ..Four anti-catabolic agents (propranolol, phentolamine, octreotide, and pentoxifylline) with different pharmacologic actions will be studied...
  14. ORTHOPEDIC SEPSIS: PATHOGENESIS, DIAGNOSIS AND TREATMENT
    Robert Fitzgerald; Fiscal Year: 1991
    ..4) concomittant therapy of antimicrobials with substances that enhance cell membrane fluidity such as pentoxifylline which locally increases chemotaxis and phagocytosis can be currative of A.H.O...
  15. Phosphodiesterase-inhibitors, vascular integrity and SCI
    Raymond J Grill; Fiscal Year: 2010
    ..acute treatment with 2 PDE-ls, a specific PDE4a-inhibitor called rolipram and a non- selective PDE-I known as pentoxifylline reduce protein extravasation following SCI;protecting the BSCB and promoting improved neurological outcome...
  16. Hepatopulmonary Syndrome Investigative Group
    Michael Fallon; Fiscal Year: 2005
    ..for exploring specific genetic polymorphisms as contributors to susceptibility and for defining whether pentoxifylline ameliorates gas exchange abnormalities...
  17. GROWTH PLATE RADIATION RESPONSE--MECHANISMS AND THERAPY
    Randy Rosier; Fiscal Year: 2000
    ..2C) We will study pentoxifylline as an additinal response modifier to: decrease cytosolic calcium and TNFalpha expression; and to stimulate ..
  18. WEAR DEBRIS OSTEOLYSIS--NEW STRATEGIES FOR PREVENTION
    REGIS O KEEFE; Fiscal Year: 2001
    ..Since some of these agents, including the phosphodiesterase inhibitor ciprofloxacin and pentoxifylline have possible clinical significance, the potential of these various agents to inhibit bone resorption will be ..
  19. MODULATION OF HEPATOCELLULAR FUNCTION IN EARLY SEPSIS
    Ping Wang; Fiscal Year: 2000
    ..TNF and IL-6 with TNF- binding proteins and anti-IL-6 antibody prevents hepatocellular dysfunction; 2) whether pentoxifylline, ATP-MgC1/2, or chemically modified heparin decreases TNF and IL-6 and subsequently prevents hepatocellular ..
  20. MODULATION OF HEPATOCELLULAR FUNCTION IN EARLY SEPSIS
    Ping Wang; Fiscal Year: 2000
    ..e., soluble TNF receptors ) and anti-IL-6 antibody prevents hepatocellular dysfunction; 2) whether pentoxifylline, ATP-MgC12, chemically modified heparin downregulates TNF and Il-6 and subsequently prevents hepatocellular ..
  21. INFLAMMATION AND MULTISTAGE CARCINOGENESIS
    Fredika Robertson; Fiscal Year: 2000
    ..the following Specific Aims are proposed: 1) Examine the ability of the cytokine synthesis inhibitor Pentoxifylline to inhibit infiltration of leukocyte populations, inhibit cytokine gene expression, inhibit DNA damage and ..
  22. CLINICAL TRIALS OF BIOLOGICAL RESPONSE MODIFIERS
    MICHAEL LOTZE; Fiscal Year: 1999
    ..of cytokines (preclinical studies of NO synthase inhibitors such as amino guanidine, TNF inhibitors such as pentoxifylline), adoptive immunotherapies using antibodies (R24, Bec2) or cellular reagents (TIL, ANK), and cytokine gene ..
  23. ACTIVATION OF HIV-1 BY SMOKING AND TUBERCULOSIS
    Zahra Toossi; Fiscal Year: 2000
    ..The antioxidant N-acetylacysteine and the tumor necrosis factor alpha(TNF) inhibitor pentoxifylline inhibit HIV production in AM from smokers...
  24. CHEMOKINE REGULATION IN PULMONARY OXYGEN INJURY
    CARL D ANGIO; Fiscal Year: 2001
    ..Interference with IL-1Beta and TNFalpha activity by the addition of IL-1 receptor antagonist (IL-1ra) and pentoxifylline, respectively, will test their necessity to the response in oxygen-exposed cells from the human U937 ..
  25. PEDIATRIC DRUG EVALUATION RESOURCE
    John Wilson; Fiscal Year: 2003
    ..Notable are pediatric therapeutic advances in a thermo-regulatory basis for antipyretic drug action, pentoxifylline for sickle cell disease, and clinical trial efficacy and safety data for a new formulation of acetaminophen ..
  26. Idiopathic Pulmonary Fibrosis Clinical Research Network
    Jay Ryu; Fiscal Year: 2009
    ..The first study will examine the effects of combined imatinib and pentoxifylline regimen compared to placebo in the treatment of IPF...
  27. REGULATION LYMPHOCYTE PROLIFERATION AND DIFFERENTIATIO
    JOAN PRESS; Fiscal Year: 2004
    ..These studies will also seek a mechanism for the inhibition of AICD by the drug pentoxifylline. Lastly, phosphorylation of IK-Ba and its effects on c-Rel versus p65 association will be analyzed by ..
  28. Induction of suppression for Islet Transplantation
    Zandong Yang; Fiscal Year: 2003
    ..This study will provide an experimental strategy of using AAV vlL-10 gene therapy to investigate immunosuppression induction in islet transplantation. ..
  29. KIDNEY RESPONSE TO RADIATION AND CHEMOTHERAPY
    JOHN MOULDER; Fiscal Year: 2006
    ..unreadable] 4) Complete the randomized, prospective, trial of the use of ACE inhibitors to prevent the development of radiation nephropathy in BMT patients. [unreadable] [unreadable]..
  30. HIV-Related Proteinuria and Endothelial Dysfunction
    Samir Gupta; Fiscal Year: 2007
    ..Dub6) in the fields of HIV metabolic and renal complications, renal vascular and glomerular pathology, and clinical trials design and implementation. ..
  31. Beneficial Effects of Chemokines in Liver
    JACQUELYN MAHER; Fiscal Year: 2007
    ..If chemokines have significant cytoprotective effects, then anti-chemokine therapy may be complicated by unwanted side effects. ..
  32. PERINATAL ESTROGEN, OXIDATIVE DAMAGES & UTERINE LESIONS
    Deodutta Roy; Fiscal Year: 2005
    ....
  33. Effect of Alcohol on HIV-1 Immune Responses & BBB Damage
    Yuri Persidsky; Fiscal Year: 2004
    ..The ability to use an in vitro BBB and an in vivo animal model will help in defining mechanisms of disease progression in the setting of alcohol abuse. ..
  34. Role of inflammation in manganese-induced neurotoxicity
    NIKOLAY FILIPOV; Fiscal Year: 2004
    ..The long-term goal of the proposed studies is to understand the role of microglia and environmental contaminants in neurodegenerative diseases. ..
  35. BLOOD FACTORS AND PERIPHERAL ARTERIAL DISEASE OUTCOMES
    Mary McDermott; Fiscal Year: 2004
    ....
  36. PERIPHERAL ARTERIAL DISEASE AND FUNCTIONAL OUTCOMES
    Mary McDermott; Fiscal Year: 2001
    ..They further state that the results of this study will be used to develop subsequent intervention studies designed to improve quality of life and prevent functional decline among men and women with PAD. ..
  37. MECHANISM AND ROLE OF MICROSOMAL ETHANOL OXIDATION
    Charles Lieber; Fiscal Year: 2001
    ..Such information is aimed at elucidating key aspects of alcohol mediated pathology in a way which may eventually affect alcohol related medical complications, their prevention and treatment. ..
  38. Mechanisms of Disability in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2005
    ..Results will be used to develop interventions designed to improve lower extremity functioning and prevent functional decline in persons with PAD. ..
  39. NONHISTONE PROTEINS AND HORMONAL CARCINOGENESIS
    Deodutta Roy; Fiscal Year: 2001
    ....
  40. Magnetic Resonance in Peripheral Arterial Disease
    Mary Mcgrae McDermott; Fiscal Year: 2010
    ..This knowledge, in subsequent studies, is expected to lead to new therapies for PAD-related functional impairment and functional decline. ..
  41. Antiviral/Antifibrotic Liver Therapy of Hepatitis C positive Alcohol Drinkers
    Charles Lieber; Fiscal Year: 2007
    ..Accordingly, support is requested for the completion of this novel approach for the treatment of HCV+ patients who become abstinent or who continue to consume alcohol moderately. [unreadable] [unreadable]..
  42. ANTIVIRAL & ANTIFIBROTIC LIVER THERAPY OF HCV+ DRINKERS
    Charles Lieber; Fiscal Year: 2005
    ..Funds are requested for special laboratory tests, study nurses, travel to meetings, patient monitoring expenses and a core office. ..
  43. Candida-endothelial interactions under conditions of flow
    Martin Thornhill; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  44. Cognitive-Behavioral Therapy & Venlafaxine Treatments For Anxiety In Alcoholism
    Domenic Ciraulo; Fiscal Year: 2007
    ..abstract_text> ..
  45. Improving Functioning in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2007
    ..By identifying the optimal exercise program for improving functioning in PAD patients with and without IC, our findings will have substantial clinical and public health implications for millions of patients with PAD. ..
  46. Inflammation and Insulin Resistance in PAD
    Mark Creager; Fiscal Year: 2007
    ..It is anticipated that the findings from this investigation will uncover novel pathophysiologic mechanisms and foster a new paradigm for the treatment of PAD. ..
  47. Inflammation and Peripheral Arterial Disease Outcomes
    Mary McDermott; Fiscal Year: 2008
    ..Results will be used to develop interventions to improve functioning and prevent functional decline in PAD. ..
  48. Low Cost Production of the Malaria Drug Artemether
    Brooks Hybertson; Fiscal Year: 2007
    ..This project seeks to develop, validate, and commercialize a new, cheaper method for producing the highly effective malaria drug artemether from the Sweet Wormwood plant. [unreadable] [unreadable] [unreadable]..
  49. Calcification of Elastin: Mechanisms and Prevention
    Naren Vyavahare; Fiscal Year: 2008
    ..Long-term objective of our program is to understand the mechanistic pathways of elastin calcification so that it can be prevented or reversed. The following specific aims will be pursued in this continuation program. ..
  50. TRAINING GRANT IN MOLECULAR CARDIOLOGY
    Mark Entman; Fiscal Year: 2008
    ..This integrated design has consistently proven to be effective in providing successful independent and competitive investigators in molecular biology of cardiovascular medicine. ..
  51. Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2008
    ..The appetite stimulating arm will include pentoxifylline 800 mg thrice weekly or its placebo...
  52. Targeting Inflammation to Improve Endothelial Function in Type 2 Diabetes: A Subs
    Mark A Creager; Fiscal Year: 2010
    ..End of Abstract) ..
  53. The Role of TIMP-1 in Uterine Physiology
    Warren Nothnick; Fiscal Year: 2005
    ..These studies will broaden our understanding on the role of TIMP-1 in uterine physiology and may help to develop new strategies to treat uterine disorders such as infertility, endometriosis and uterine cancer. ..
  54. The Effect of Statins on Skeletal Muscle Function
    PAUL DAVIS THOMPSON; Fiscal Year: 2010
    ....
  55. Liver Fibrosis, Inflammation & Oxidative Stress Markers
    Charles Lieber; Fiscal Year: 2006
    ..abstract_text> ..