xanthines

Summary

Summary: Purine bases found in body tissues and fluids and in some plants.

Top Publications

  1. pmc Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine
    Andrew S Doré
    Heptares Therapeutics Ltd, BioPark, Welwyn Garden City, Herts, AL7 3AX, UK
    Structure 19:1283-93. 2011
  2. ncbi Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines
    Vasudeva Raghavendra
    Department of Anesthesiology, HB 7125, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Pain 104:655-64. 2003
  3. pmc KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels
    Bin Nan Wu
    Department of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Br J Pharmacol 142:1105-14. 2004
  4. ncbi Chemical and nutritional composition of tejate, a traditional maize and cacao beverage from the Central Valleys of Oaxaca, Mexico
    Angela Sotelo
    Departamento de Farmacia, Facultad de Quimica, Laboratorio 111, Universidad Nacional Autonoma de Mexico, 04510 Mexico, DF, Mexico
    Plant Foods Hum Nutr 67:148-55. 2012
  5. pmc KMUP-1 relaxes rabbit corpus cavernosum smooth muscle in vitro and in vivo: involvement of cyclic GMP and K(+) channels
    Rong Jyh Lin
    Department of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Br J Pharmacol 135:1159-66. 2002
  6. pmc A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 118:3301-15. 2008
  7. pmc Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat
    Young Seob Gwak
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1043, USA
    Pain 138:410-22. 2008
  8. ncbi Methylxanthines are the psycho-pharmacologically active constituents of chocolate
    Hendrik J Smit
    Department of Experimental Psychology, University of Bristol, 8 Woodland Road, Bristol, BS8 1TN, UK
    Psychopharmacology (Berl) 176:412-9. 2004
  9. ncbi Nucleus accumbens and effort-related functions: behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors
    A M Farrar
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Neuroscience 166:1056-67. 2010
  10. ncbi Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors
    Tobias Eckle
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Circulation 115:1581-90. 2007

Research Grants

  1. STRUCTURE OF ADENOSINE RECEPTORS
    Jack Wells; Fiscal Year: 2002
  2. ADENOSINE RECEPTOR MODULATION OF SEIZURE SUSCEPTIBILITY
    Thomas Murray; Fiscal Year: 1990
  3. DEVELOPMENTAL REGULATION OF HYPERCAPNIC RESPONSES
    Richard Martin; Fiscal Year: 2006
  4. CHROMATIN CONFORMATION AND PLD REPAIR
    Yvonne Taylor; Fiscal Year: 1992
  5. CYCLIC AMP/ADENOSINE PATHWAY
    Edwin Jackson; Fiscal Year: 2002
  6. MOTOR EFFECTS OF ATYPICAL ANTIPSYCHOTICS
    John Salamone; Fiscal Year: 2003
  7. Effort-related Functions of Nucleus Accumbens Adenosine A2A Receptors
    John D Salamone; Fiscal Year: 2010
  8. Dopamine D2 and Adenosine A2A roles:Tremulous Movements
    John Salamone; Fiscal Year: 2007
  9. BEHAVIORAL EFFECTS OF NIGRAL D1 ANTAGONISM
    John Salamone; Fiscal Year: 2001
  10. HYPOXIA AND CONTROL OF FETAL BREATHING MOVEMENTS
    Brian J Koos; Fiscal Year: 2010

Detail Information

Publications214 found, 100 shown here

  1. pmc Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine
    Andrew S Doré
    Heptares Therapeutics Ltd, BioPark, Welwyn Garden City, Herts, AL7 3AX, UK
    Structure 19:1283-93. 2011
    ..Here we report the structures of a thermostabilized adenosine A(2A) receptor in complex with the xanthines xanthine amine congener and caffeine, as well as the A(2A) selective inverse agonist ZM241385...
  2. ncbi Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines
    Vasudeva Raghavendra
    Department of Anesthesiology, HB 7125, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Pain 104:655-64. 2003
    ....
  3. pmc KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels
    Bin Nan Wu
    Department of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Br J Pharmacol 142:1105-14. 2004
    ....
  4. ncbi Chemical and nutritional composition of tejate, a traditional maize and cacao beverage from the Central Valleys of Oaxaca, Mexico
    Angela Sotelo
    Departamento de Farmacia, Facultad de Quimica, Laboratorio 111, Universidad Nacional Autonoma de Mexico, 04510 Mexico, DF, Mexico
    Plant Foods Hum Nutr 67:148-55. 2012
    ..Its substitution by sodas and other high glycemic beverages may have negative nutritional, health and cultural consequences...
  5. pmc KMUP-1 relaxes rabbit corpus cavernosum smooth muscle in vitro and in vivo: involvement of cyclic GMP and K(+) channels
    Rong Jyh Lin
    Department of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Br J Pharmacol 135:1159-66. 2002
    ..We suggest that these merits play prominent roles in KMUP-1-induced CCSM relaxation-associated increases of ICP and penile erection...
  6. pmc A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 118:3301-15. 2008
    ..Taken together, these studies reveal a role for A2BAR signaling in attenuating VILI and implicate this receptor as a potential therapeutic target during acute lung injury...
  7. pmc Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat
    Young Seob Gwak
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1043, USA
    Pain 138:410-22. 2008
    ..05). In conclusion, our present data demonstrate that propentofylline modulates glia activation and GABAergic inhibitory tone by modulation of GAD(65) protein expression following spinal cord injury...
  8. ncbi Methylxanthines are the psycho-pharmacologically active constituents of chocolate
    Hendrik J Smit
    Department of Experimental Psychology, University of Bristol, 8 Woodland Road, Bristol, BS8 1TN, UK
    Psychopharmacology (Berl) 176:412-9. 2004
    ..Liking, cravings and addiction for chocolate ("chocoholism") are often explained through the presence of pharmacologically active compounds. However, mere "presence" does not guarantee psycho-activity...
  9. ncbi Nucleus accumbens and effort-related functions: behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors
    A M Farrar
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Neuroscience 166:1056-67. 2010
    ..These findings may have implications for the treatment of psychiatric symptoms such as psychomotor slowing, anergia and fatigue...
  10. ncbi Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors
    Tobias Eckle
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Circulation 115:1581-90. 2007
    ..Once generated, adenosine can activate cell-surface adenosine receptors (A1 AR, A2A AR, A2B AR, A3 AR). In the present study, we define the contribution of adenosine to cardioprotection by ischemic preconditioning...
  11. ncbi Piperazine-designed alpha 1A/alpha 1D-adrenoceptor blocker KMUP-1 and doxazosin provide down-regulation of androgen receptor and PSA in prostatic LNCaP cells growth and specifically in xenografts
    Chi Ming Liu
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Prostate 69:610-23. 2009
    ..This study is aimed to further investigate whether KMUP-1 and doxazosin prevent from prostate cancer cell growth via androgen-dependent and -independent pathway in vivo and in vitro...
  12. pmc A xanthine-based KMUP-1 with cyclic GMP enhancing and K(+) channels opening activities in rat aortic smooth muscle
    B N Wu
    Department of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan ROC
    Br J Pharmacol 134:265-74. 2001
    ..Increased cyclic GMP display a prominent role in KMUP-1-induced VSM relaxations...
  13. ncbi Binding of [3H]MSX-2 (3-(3-hydroxypropyl)-7-methyl-8-(m-methoxystyryl)-1-propargylxanthine) to rat striatal membranes--a new, selective antagonist radioligand for A(2A) adenosine receptors
    C E Muller
    Pharmaceutical Institute, Universitat Bonn, Germany
    Eur J Pharm Sci 10:259-65. 2000
    ..The new radioligand shows high specific radioactivity (85 Ci/mmol, 3150 GBq/mmol) and acceptable nonspecific binding at rat striatal membranes of 20-30%, at 1 nM...
  14. ncbi Attenuation of morphine tolerance, withdrawal-induced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats
    Vasudeva Raghavendra
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Neuropsychopharmacology 29:327-34. 2004
    ..These results further support the hypothesis that spinal glia and proinflammatory cytokines contribute to the mechanisms of morphine tolerance and associated abnormal pain sensitivity...
  15. ncbi Expression of human equilibrative nucleoside transporter 1 in mouse neurons regulates adenosine levels in physiological and hypoxic-ischemic conditions
    Dali Zhang
    Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada
    J Neurochem 118:4-11. 2011
    ....
  16. pmc KMUP-1 attenuates isoprenaline-induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways
    Jwu Lai Yeh
    Department and Graduate Institute of Pharmacology, Kaohsiung Medical University, Taiwan
    Br J Pharmacol 159:1151-60. 2010
    ..To determine whether KMUP-1, a novel xanthine-based derivative, attenuates isoprenaline (ISO)-induced cardiac hypertrophy in rats, and if so, whether the anti-hypertrophic effect is mediated by the nitric oxide (NO) pathway...
  17. ncbi Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido[1,2,3-cd]purinediones
    Stefanie Weyler
    University of Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry Poppelsdorf, Kreuzbergweg 26, 53115 Bonn, Germany
    ChemMedChem 1:891-902. 2006
    ..Their efficacy was generally lower than that of the full inverse agonist DPCPX, and depended on subtle structural changes. Some of the new compounds belong to the most potent and selective A(1) antagonists described to date...
  18. ncbi cGMP-enhancing- and alpha1A/alpha1D-adrenoceptor blockade-derived inhibition of Rho-kinase by KMUP-1 provides optimal prostate relaxation and epithelial cell anti-proliferation efficacy
    Chi Ming Liu
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Prostate 67:1397-410. 2007
    ..This study is aimed to examine the relaxation activities of a sGC activator and PDE5A/ROCK2 inhibitor KMUP-1 in rat prostate and associated anti-proliferation activity in human prostatic epithelial cells...
  19. ncbi Simultaneous HPLC determination of caffeine, theobromine, and theophylline in food, drinks, and herbal products
    Branislava Srdjenovic
    Medical Faculty, Department of Pharmacy, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia
    J Chromatogr Sci 46:144-9. 2008
    ..The within- and between-day precision is determined for both retention times and peak area. The data suggests that the proposed HPLC method can be used for routine quality control of food, drinks, and herbal products...
  20. ncbi A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists
    Luo Yan
    Pharmaceutical Institute, Pharmaceutical Chemistry Poppelsdorf, University of Bonn, Kreuzbergweg 26, D 53115 Bonn, Germany
    J Med Chem 49:4384-91. 2006
    ..6 nM for the human A(2B) receptor combined with high selectivity versus the other human adenosine receptor subtypes (575-fold versus A(1), 134-fold versus A(2A), and >278-fold versus A(3))...
  21. pmc Diversity of cacao trees in Waslala, Nicaragua: associations between genotype spectra, product quality and yield potential
    Bodo Trognitz
    Dept Health and Environment, AIT Austrian Institute of Technology, Tulln, Austria
    PLoS ONE 8:e54079. 2013
    ..Fast and gentle air-drying of the fermented beans and their permanent dry storage were an efficient and comparatively easy precondition for high cocoa quality...
  22. ncbi KMUP-1 attenuates serum deprivation-induced neurotoxicity in SH-SY5Y cells: roles of PKG, PI3K/Akt and Bcl-2/Bax pathways
    Ya Yun Hsu
    Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Toxicology 268:46-54. 2010
    ..In conclusion, cGMP/PKG, PI3K/Akt/CREB and Bcl-2/Bax signals play critical roles in the neuroprotective effects of KMUP-1 on serum deprivation-induced toxicity...
  23. ncbi Multigram-scale syntheses, stability, and photoreactions of A2A adenosine receptor antagonists with 8-styrylxanthine structure: potential drugs for Parkinson's disease
    Jorg Hockemeyer
    University of Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry Poppelsdorf, Kreuzbergweg 26, D 53115 Bonn, Germany
    J Org Chem 69:3308-18. 2004
    ..57 microM). The light sensitivity of 8-styrylxanthine derivatives, not only in solution, but also in the solid state, has to be considered when using those compounds as pharmacological tools or drugs...
  24. pmc Injections of the selective adenosine A2A antagonist MSX-3 into the nucleus accumbens core attenuate the locomotor suppression induced by haloperidol in rats
    Keita Ishiwari
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Behav Brain Res 178:190-9. 2007
    ..These studies suggest that adenosine and dopamine systems interact to modulate the locomotor and behavioral activation functions of nucleus accumbens core...
  25. pmc Quantitative analysis of the formation and diffusion of A1-adenosine receptor-antagonist complexes in single living cells
    S J Briddon
    Institute of Cell Signalling, Medical School, University of Nottingham, Nottingham NG7 2UH, United Kingdom
    Proc Natl Acad Sci U S A 101:4673-8. 2004
    ..The combination of FCS with XAC-BY630 will be a powerful tool for the characterization of ligand-A1-AR interactions in single living cells in health and disease...
  26. pmc Xanthines down-regulate the drug transporter ABCG2 and reverse multidrug resistance
    Rui Ding
    Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA
    Mol Pharmacol 81:328-37. 2012
    ..In this study, we found that a group of xanthines including caffeine, theophylline, and dyphylline can dramatically decrease ABCG2 protein in cells that have ..
  27. ncbi 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity
    Thomas Borrmann
    PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, D 53121 Bonn, Germany
    J Med Chem 52:3994-4006. 2009
    ..It was shown to be a useful pharmacological tool for the selective labeling of human as well as rodent A(2B) receptors (K(D) human A(2B) 0.403 nM, mouse A(2B) 0.351 nM)...
  28. ncbi Structural basis for the binding affinity of xanthines with the DNA intercalator acridine orange
    M B Lyles
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA
    J Med Chem 44:4650-60. 2001
    ..was used to determine the binding affinities (K(assoc)) and structural effects of a series of methyl-substituted xanthines and a series of methyl-substituted uric acids (8-oxoxanthine) with the known DNA intercalator acridine orange (..
  29. pmc The adenosine A2A antagonist MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit procedure
    Allison M Mott
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Psychopharmacology (Berl) 204:103-12. 2009
    ....
  30. ncbi Frequency facilitation at mossy fiber-CA3 synapses of freely behaving rats is regulated by adenosine A1 receptors
    Jens Klausnitzer
    Department of Experimental Neurophysiology, Medical Faculty, Ruhr University Bochum, 44780 Bochum, Germany
    J Neurosci 28:4836-40. 2008
    ....
  31. ncbi Adenosine A(2A) receptor antagonism reverses the effects of dopamine receptor antagonism on instrumental output and effort-related choice in the rat: implications for studies of psychomotor slowing
    Andrew M Farrar
    Department of Psychology, University of Connecticut, Storrs, CT, 06269 1020, USA
    Psychopharmacology (Berl) 191:579-86. 2007
    ..Dopamine antagonism and accumbens dopamine depletions cause rats performing on choice tasks to reallocate their behavior away from food-reinforced tasks that have high response requirements...
  32. pmc A2B adenosine receptor dampens hypoxia-induced vascular leak
    Tobias Eckle
    Departments of Anesthesiology and Intensive Care, Tubingen University Hospital, Tubingen, Germany
    Blood 111:2024-35. 2008
    ..Taken together, these studies provide pharmacologic and genetic evidence for vascular A2BAR signaling as central control point of hypoxia-associated vascular leak...
  33. pmc Differential migration, LPS-induced cytokine, chemokine, and NO expression in immortalized BV-2 and HAPI cell lines and primary microglial cultures
    Ryan J Horvath
    Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire, USA
    J Neurochem 107:557-69. 2008
    ..These results indicate that BV-2 and HAPI cell cultures only partially model primary microglia and that their use should therefore be carefully considered...
  34. pmc Adenosinergic modulation of respiratory neurones in the neonatal rat brainstem in vitro
    E Herlenius
    Karolinska Institutet, Neonatal Unit, Department of Woman and Child Health, Astrid Lindgren Children s Hospital, S 171 76 Stockholm, Sweden
    J Physiol 518:159-72. 1999
    ..Furthermore, our data demonstrate that inactivation of expiratory neurones does not abolish the respiratory rhythmic activity, but only modulates respiratory rhythm in vitro...
  35. pmc Activation of p-38alpha MAPK contributes to neuronal hyperexcitability in caudal regions remote from spinal cord injury
    Young S Gwak
    Department of Neuroscience, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1043, USA
    Exp Neurol 220:154-61. 2009
    ..05). In conclusion, our present data demonstrate that activated neuronal and microglial, but not astrocytic, p-38alpha MAPK contributes to the maintenance of neuronal hyperexcitability in caudal regions following spinal cord injury...
  36. pmc Differential actions of adenosine A1 and A2A antagonists on the effort-related effects of dopamine D2 antagonism
    John D Salamone
    Division of Behavioral Neuroscience, Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Behav Brain Res 201:216-22. 2009
    ....
  37. pmc Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses
    Kimberly A Moore
    Department of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 100:14397-402. 2003
    ....
  38. ncbi Correlation between emetic effect of phosphodiesterase 4 inhibitors and their occupation of the high-affinity rolipram binding site in Suncus murinus brain
    Ryo Hirose
    Pharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, 1188 Shimotogari, Nagaizumi, Shizuoka, 411 8731, Japan
    Eur J Pharmacol 573:93-9. 2007
    ..We conclude that the emetic effect of phosphodiesterase 4 inhibitors is caused at least in part via binding to the high-affinity rolipram binding site in brain in vivo...
  39. ncbi The modulation of the DNA-damaging effect of polycyclic aromatic agents by xanthines. Part I. Reduction of cytostatic effects of quinacrine mustard by caffeine
    Jan Kapuscinski
    Laboratory of Biophysical Chemistry, Department of Molecular and Cellular Biology, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Kladki 24, 80 822, Gdansk, Poland
    Biochem Pharmacol 63:625-34. 2002
    ..There are also reports about protective effect of caffeine and other xanthines against tumors induced by polycyclic aromatic hydrocarbons...
  40. ncbi Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes
    Francesco V Rao
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Scotland
    Chem Biol 12:973-80. 2005
    ..Mutagenesis identified the key active site residues, conserved in mammalian chitinases, which contribute to inhibitor affinity. Enzyme assays also revealed that these methylxanthines are active against human chitinases...
  41. ncbi Evaluation of distribution of adenosine A2A receptors in normal human brain measured with [11C]TMSX PET
    Masahiro Mishina
    Neurological Institute, Nippon Medical School Chiba Hokusoh Hospital, Imba gun, Chiba ken 270 1694, Japan
    Synapse 61:778-84. 2007
    ..To date, [(11)C]TMSX is the only promising PET ligand, which is available to clinical use for mapping the A2ARs in the living human brain...
  42. ncbi Preclinical studies on [11C]TMSX for mapping adenosine A2A receptors by positron emission tomography
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ann Nucl Med 17:205-11. 2003
    ..We have concluded that [11C]TMSX is suitable for mapping adenosine A2A receptors in the human brain by PET...
  43. ncbi Modified micellar electrokinetic chromatography in the analysis of catechins and xanthines in chocolate
    Roberto Gotti
    Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Bologna, Italy
    Electrophoresis 25:3282-91. 2004
    ..The CD-MEKC approach was validated and applied to the determination of catechins and methylxanthines in aqueous extracts from four different commercial chocolate types (black and milk) and two cocoa powders...
  44. ncbi First visualization of adenosine A(2A) receptors in the human brain by positron emission tomography with [11C]TMSX
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Synapse 55:133-6. 2005
    ..The [11C]TMSX PET is of great interest for studying the pathophysiology of neurological and psychiatric disorders together with the [11C]raclopride PET for D2Rs evaluation and/or the [11C]MPDX PET for A1Rs evaluation...
  45. ncbi Imaging of adenosine A1 receptors in the human brain by positron emission tomography with [11C]MPDX
    Nobuyoshi Fukumitsu
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ann Nucl Med 17:511-5. 2003
    ..The [11C]MPDX PET has the potential for mapping adenosine A1 receptors in the human brain...
  46. ncbi The modulation by xanthines of the DNA-damaging effect of polycyclic aromatic agents. Part II. The stacking complexes of caffeine with doxorubicin and mitoxantrone
    Jacek Piosik
    Intercollegiate Faculty of Biotechnology, Department of Molecular and Cellular Biology, Laboratory of Biophysical Chemistry, University of Gdansk and Medical University of Gdansk, Kladki 24, 80 822, Gdansk, Poland
    Biochem Pharmacol 63:635-46. 2002
    ..There are also reports about protective effect of caffeine and other xanthines against tumors induced by polycyclic aromatic hydrocarbons...
  47. ncbi Activation of synaptic NMDA receptors by action potential-dependent release of transmitter during hypoxia impairs recovery of synaptic transmission on reoxygenation
    A M Sebastiao
    Laboratory of Neurosciences, Faculty of Medicine of Lisbon, 1649 028 Lisbon, Portugal
    J Neurosci 21:8564-71. 2001
    ....
  48. pmc Antagonist selective modulation of adenosine A1 and A3 receptor pharmacology by the food dye Brilliant Black BN: evidence for allosteric interactions
    L T May
    Institute of Cell Signaling, The University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Mol Pharmacol 77:678-86. 2010
    ..Taken together, these results suggest that Brilliant Black BN can act allosterically to modify ligand affinity at A(1) and A(3) receptors...
  49. ncbi Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease
    J F Chen
    Molecular Neurobiology Laboratory, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci 21:RC143. 2001
    ..These data establish a potential neural basis for the inverse association of caffeine with the development of PD, and they enhance the potential of A(2A) antagonists as a novel treatment for this neurodegenerative disease...
  50. ncbi [Recommended treatment of apnea in premature infants. A review based on literature and own experience]
    Klaudiusz Bober
    Klinika Intensywnej Terapii i Patologii Noworodka, Górnoślaskie Centrum Zdrowia Dziecka, Slaski Uniwersytet Medyczny, 40 752 Katowice
    Med Wieku Rozwoj 12:846-50. 2008
    ..The compiled recommendations are based on the data from literature and from the authors' own experiences...
  51. ncbi Characterization of "mini-nucleotides" as P2X receptor agonists in rat cardiomyocyte cultures. An integrated synthetic, biochemical, and theoretical study
    B Fischer
    Department of Chemistry and Faculty of Life Sciences, Gonda Goldschmied Medical Research Center, Bar Ilan University, Ramat Gan 52900, Israel
    J Med Chem 42:2685-96. 1999
    ..Therefore, these analogues may serve as prototypes of selective drugs aiming at cardiac disorders mediated through P2X receptors...
  52. ncbi Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists
    Rao V Kalla
    Department of Bioorganic Chemistry, CV Therapeutics Inc, 3172 Porter Drive, Palo Alto, California 94304, USA
    J Med Chem 49:3682-92. 2006
    ..attempt to identify a high-affinity, selective antagonist for the A(2B) AdoR, we synthesized 8-(C-4-pyrazolyl) xanthines. Compound 22, 8-(1H-pyrazol-4-yl)-1,3-dipropyl xanthine, is a N-1 unsubstituted pyrazole derivative that has ..
  53. ncbi Behavioral and physiological effects of xanthines in nonhuman primates
    L L Howell
    Yerkes Regional Primate Research Center, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 129:1-14. 1997
    Caffeine and related xanthines can have significant behavioral effects on measures of locomotor activity, schedule-controlled behavior, drug self-administration, and learning and memory...
  54. ncbi A functional role for adenosine A3 receptors: modulation of synaptic plasticity in the rat hippocampus
    A R Costenla
    Laboratory of Neurosciences, Faculty of Medicine of Lisbon, Avenue Professor Egas Moniz, 1649-028, Lisbon, Portugal
    Neurosci Lett 302:53-7. 2001
    ..The selective adenosine A3 receptor antagonist, MRS 1191 (5-10 microM), prevented the effects of Cl-IBMECA. These findings indicate a functional role for adenosine A3 receptors in the modulation of synaptic plasticity...
  55. ncbi Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade
    Sebastian Philipp
    Department of Physiology, University of South Alabama, College of Medicine, Mobile, AL 36688, United States
    Cardiovasc Res 70:308-14. 2006
    ..Ischemic postconditioning protects the reperfused heart from infarction, and this protection is dependent on the occupancy of adenosine receptors. We further explored the role of adenosine receptors in this salvage...
  56. ncbi Hypotensive effects of intravenously administered uridine and cytidine in conscious rats: involvement of adenosine receptors
    M Sertac Yilmaz
    Uludag University Faculty of Medicine, Department of Pharmacology and Clinical Pharmacology, 16059, Gorukle, Bursa, Turkey
    Eur J Pharmacol 584:125-36. 2008
    ..The data also implicates that the mainly adenosine A(1) receptor activation is involved in the uridine-induced cardiovascular effects, while both adenosine A(1) and A(2A) receptor activations mediate the cytidine's effects...
  57. ncbi Efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury
    Vivianne L Tawfik
    Department of Pharmacology, Dartmouth Medical School, Hanover, NH 03755, USA
    Brain Behav Immun 21:238-46. 2007
    ..Taken together, our results highlight the clinical potential of the glial modulating agent, propentofylline, for the treatment of neuropathic pain as well as a role for microglia in the long-term maintenance of allodynia...
  58. ncbi A comparison of the antagonist affinities for the Gi- and Gs-coupled states of the human adenosine A1-receptor
    Jillian G Baker
    Institute of Cell Signaling, Queen s Medical Centre, Nottingham NG7 2UH, UK
    J Pharmacol Exp Ther 320:218-28. 2007
    ..This was true even when the receptor was shown, in the same assay, to exist in two different conformational states coupled to two different G proteins...
  59. ncbi Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment
    Stephen P Hack
    Pain Management Research Institute, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia
    J Neurosci 25:3192-8. 2005
    ..These results suggest that induction of DOPr-mediated actions in PAG by chronic morphine requires prolonged MOPr stimulation and expression of beta-arrestin-2...
  60. ncbi Disruption of the A(3) adenosine receptor gene in mice and its effect on stimulated inflammatory cells
    C A Salvatore
    Department of Pharmacology, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Biol Chem 275:4429-34. 2000
    ..These results show that the inhibition in vivo can be mediated by multiple subtypes, specifically the A(3) and A(2A) adenosine receptors, and A3AR activation plays an important role in both pro- and anti-inflammatory responses...
  61. pmc Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection
    V L Tawfik
    Department of Pharmacology, Dartmouth Medical School, Hanover, NH 03755, USA
    Neuroscience 152:1086-92. 2008
    ..The ability of propentofylline to alter glial glutamate transporters highlights the importance of controlling aberrant glial activation in neuropathic pain and suggests one possible mechanism for the anti-allodynic action of this drug...
  62. ncbi Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability
    Luo Yan
    University of Bonn, Pharmaceutical Chemistry Poppelsdorf, Pharmaceutical Sciences, Bonn, Germany
    J Med Chem 47:1031-43. 2004
    ..This new protection strategy allowed for the upscaling of the synthesis of 1-propyl-8-p-sulfophenylxanthine (PSB-1115), a selective A(2B) antagonist...
  63. ncbi Propentofylline attenuates vincristine-induced peripheral neuropathy in the rat
    S M Sweitzer
    Department of Pharmacology and Toxicology, Dartmouth Medical School, HB 7650, Hanover, NH 03755, USA
    Neurosci Lett 400:258-61. 2006
    ..These data suggest that central glial cells may play an important role in the development of painful neuropathy following vincristine administration...
  64. ncbi Caffeine and a selective adenosine A2A receptor antagonist induce reward and sensitization behavior associated with increased phospho-Thr75-DARPP-32 in mice
    Chih W Hsu
    Department of Emergency Medicine, Tzu Chi General Hospital, Hualien 970, Taiwan
    Psychopharmacology (Berl) 204:313-25. 2009
    ....
  65. ncbi Intrathecal adenosine following spinal nerve ligation in rat: short residence time in cerebrospinal fluid and no change in A(1) receptor binding
    Carsten Bantel
    Department of Anesthesiology, Wake Forst University Schhol of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 96:103-8. 2002
    ..The purpose of the current study was to investigate whether this reflected an alteration in kinetics of adenosine in cerebrospinal fluid or in the number of spinal A1 adenosine receptors after nerve injury...
  66. ncbi Induction of astrocyte differentiation by propentofylline increases glutamate transporter expression in vitro: heterogeneity of the quiescent phenotype
    Vivianne L Tawfik
    Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire 03756, USA
    Glia 54:193-203. 2006
    ..These findings suggest that PPF is capable of differentiating astrocytes to a homeostatic, mature phenotype, competent for glutamate clearance and distinct from that induced by db-cAMP...
  67. ncbi Adenosine A(1) and A(2A) receptors modulate sleep state and breathing in fetal sheep
    B J Koos
    Nicholas S Assali Perinatal Research Laboratory, Department of Obstetrics and Gynecology and The Brain Research Institute, University of California at Los Angeles School of Medicine, Los Angeles, California 90095 1740, USA
    J Appl Physiol (1985) 91:343-50. 2001
    ....
  68. ncbi Species comparison of adenosine A1 receptors in isolated mammalian atrial and ventricular myocardium
    Chris L Kapicka
    Department of Biology, Northwest Nazarene University, Nampa, ID 83686, USA
    Life Sci 72:2825-38. 2003
    ..Our results indicate definite species differences as well as tissue differences between rat and guinea pig. These differences must be considered when interpreting studies using rat and guinea pig tissue as models for cardiac function...
  69. ncbi Cloning and functional characterization of a human A1 adenosine receptor
    F Libert
    Institut de Recherche Interdisciplinaire, Faculte de Medecine, Universite Libre de Bruxelles, Belgium
    Biochem Biophys Res Commun 187:919-26. 1992
    ..The rank order of affinities observed was typical of an A1 adenosine receptor. A Kd value of 2.28 nM was determined using [3H]DPCPX [dipropylcyclopentyl-xanthine], an A1 selective antagonist...
  70. ncbi Selective, high affinity A(2B) adenosine receptor antagonists: N-1 monosubstituted 8-(pyrazol-4-yl)xanthines
    Rao V Kalla
    Department of Bioorganic Chemistry, CV Therapeutics Inc, 3172 Porter Drive, Palo Alto, CA 94304, USA
    Bioorg Med Chem Lett 18:1397-401. 2008
    A series of N-1 monosubstituted 8-pyrazolyl xanthines have been synthesized and evaluated for their affinity for the adenosine receptors (AdoRs)...
  71. ncbi Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain
    S M Sweitzer
    Department of Pharmacology and Toxicology, Dartmouth College, Hanover, New Hampshire, USA
    J Pharmacol Exp Ther 297:1210-7. 2001
    ....
  72. ncbi Activation of p38 and p42/44 MAP kinase in neuropathic pain: involvement of VPAC2 and NK2 receptors and mediation by spinal glia
    E M Garry
    Centre for Neuroscience, Division of Veterinary Biomedical Sciences, University of Edinburgh, EH9 1QH, UK
    Mol Cell Neurosci 30:523-37. 2005
    ..Thus, spinal p38 and p42/44 MAP kinases are activated in neuropathic pain states by mechanisms involving VPAC2, NK2, NMDA receptors and glial cytokine production...
  73. ncbi Development of new fluorescent xanthines as kinase inhibitors
    Donghee Kim
    Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon, 305 701, Korea
    Org Lett 12:1212-5. 2010
    ..For example, compound 8a inhibits PI3Ks and proliferation in T47D tumor cells. In addition, these xanthine-based kinase inhibitors exhibited significant fluorescence emission in a concentration-dependent response...
  74. ncbi Adenosine A1 receptor mapping of the human brain by PET with 8-dicyclopropylmethyl-1-11C-methyl-3-propylxanthine
    Nobuyoshi Fukumitsu
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Nucl Med 46:32-7. 2005
    ..In this study, we quantitatively evaluated the distribution of a major subtype A(1) adenosine receptor in the human brain by PET with a newly developed radioligand, 8-dicyclopropylmethyl-1-(11)C-methyl-3-propylxanthine ((11)C-MPDX)...
  75. ncbi Anti-TNF-alpha properties of new 9-benzyladenine derivatives with selective phosphodiesterase-4- inhibiting properties
    J M Reimund
    , , UFR de Sciences Pharmaceutiques, 74 route du Rhin, 67401 Illkirch Cedex, France
    Biochem Biophys Res Commun 288:427-34. 2001
    ..Our results suggest that some of these new adenines (i.e., NCS 675 and NCS 700), may be potential therapeutic candidates for the treatment of inflammatory diseases...
  76. ncbi 6-(N-benzoylamino)purine as a novel and potent inhibitor of xanthine oxidase: inhibition mechanism and molecular modeling studies
    Hemlata Tamta
    Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar, Punjab, India
    J Enzyme Inhib Med Chem 20:317-24. 2005
    ....
  77. ncbi Morphine can enhance the antiallodynic effect of intrathecal R-PIA in rats with nerve ligation injury
    Jai Hyun Hwang
    Department of Anesthesia and Pain Medicine, University of Ulsan, College of Medicine, Asan Medical Center, 388 1 Pungnap dong, Songpa Gu, Seoul 138 736, Korea
    Anesth Analg 100:461-8. 2005
    ..These results suggest that activation of mu-opioid and A1 receptors at the spinal level is required for the synergistic interaction on tactile allodynia...
  78. ncbi Rapid tolerance to focal cerebral ischemia in rats is attenuated by adenosine A1 receptor antagonist
    Michiko Nakamura
    Department of Anesthesiology Resuscitology, Yamaguchi University School of Medicine, Yamaguchi, Japan
    J Cereb Blood Flow Metab 22:161-70. 2002
    ....
  79. ncbi [Action of AMP579 and adenosine on potassium or sodium ionic channels in isolated rat and guinea pig ventricular myocytes]
    Xiong Wang
    Department of Cardiology, First Hospital, Shanxi Medical University, Taiyuan 030001, China
    Yao Xue Xue Bao 41:716-20. 2006
    ..To study the effect of AMP579 and adenosine on potassium ionic (K+) or sodium ionic (Na+) channels and to elucidate ionic mechanisms underlying negative inotropic and antiarrhythmic effects of AMP579 and adenosine...
  80. ncbi Adenosine is upregulated during peritonitis and is involved in downregulation of inflammation
    B Rogachev
    Department of Nephrology, Soroka Medical Center and Ben Gurion University of the Negev, Beer Sheva, Israel
    Kidney Int 70:675-81. 2006
    ..Future treatment with adenosine agonists should be considered for attenuating the damage to mesothelium during the course of acute peritonitis...
  81. ncbi Disruption of adenosinergic modulation of ventilation at rest and during hypercapnia by neonatal caffeine in young rats: role of adenosine A(1) and A(2A) receptors
    Gaspard Montandon
    Department of Pediatric, Laval University, Centre de Recherche Hôpital St François d Assise D0 711 10 rue de l Espinay, Quebec, QC, Canada G1L 3L5
    Am J Physiol Regul Integr Comp Physiol 292:R1621-31. 2007
    ..NCT elicits developmental plasticity of adenosinergic modulation, since neonatal caffeine persistently decreases ventilatory sensitivity to adenosine blockers...
  82. ncbi Adenosine A1 receptors modulate the anxiolytic-like effect of ethanol in the elevated plus-maze in mice
    Rui D S Prediger
    Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, UFSC, Rua Ferreira Lima 82, Florianopolis, SC 88015 420, Brazil
    Eur J Pharmacol 499:147-54. 2004
    ..6 g/kg). These results reinforce the involvement of adenosine in anxiety and suggest that the activation of adenosine A1 receptors, but not adenosine A(2A) receptors, mediate the anxiolytic-like effect induced by ethanol in mice...
  83. ncbi Effects of adenosine on optic nerve head circulation in rabbits
    Mami Hirao
    Department of Ophthalmology, Osaka Medical College, 2 7 Daigaku cho, Takatsuki, Osaka 569 8686, Japan
    Exp Eye Res 79:729-35. 2004
    ..Activation of K(ATP) channels is strongly related to the mechanism of adenosine-induced increase in ONH blood flow, while the participation of adenylate cyclase is less likely...
  84. ncbi The anticonvulsant action of propofol on epileptiform activity in rat hippocampal slices
    Hideya Ohmori
    Department of Anesthesiology, Kitami Red Cross Hospital, Japan
    Anesth Analg 99:1095-101, table of contents. 2004
    ..The results demonstrated that, in rat hippocampal slices, propofol inhibits epileptiform activity. In addition, adenosine neuromodulation through the A(1) receptor may contribute to the anticonvulsant action of propofol...
  85. ncbi Caffeine inhibition of rat carotid body chemoreceptors is mediated by A2A and A2B adenosine receptors
    S V Conde
    Departamento de Bioquímica y Biología Molecular y Fisiología Instituto de Biología y Genética Molecular, Universidad de Valladolid Consejo Superior de Investigaciones Científicas, Facultad de Medicina, Valladolid, Spain
    J Neurochem 98:616-28. 2006
    ..It is concluded that endogenous adenosine, via presynaptic A2B and postsynaptic A2A receptors, can exert excitatory effects on the overall output of the rat CB chemoreceptors...
  86. ncbi Adenosine A1 receptor blockade mimics caffeine's attenuation of ethanol-induced motor incoordination
    Laura Connole
    Department of Safety Pharmacology, H Lundbeck A S, Valby, Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol 95:299-304. 2004
    ....
  87. ncbi Role of adenosine A1 receptors in the modulation of dopamine D1 and adenosine A2A receptor signaling in the neostriatum
    K Yabuuchi
    Oita University Faculty of Medicine, Yufu, Oita 879 5593, Japan
    Neuroscience 141:19-25. 2006
    ..In conclusion, A(1) receptors play a major modulatory role in dopamine and adenosine receptor signaling...
  88. ncbi Progress in the pursuit of therapeutic adenosine receptor antagonists
    Stefano Moro
    Molecular Modeling Section, Dipartimento di Scienze Farmaceutiche, Universita di Padova, Via Marzolo 5, I 35131 Padova, Italy
    Med Res Rev 26:131-59. 2006
    ..In this review, we will summarize the most relevant progress in developing new therapeutic adenosine receptor antagonists...
  89. ncbi A detailed behavioral analysis of the acute motor effects of caffeine in the rat: involvement of adenosine A1 and A2A receptors
    Katerina Antoniou
    Department of Pharmacology, Medical School, University of Ioannina, Greece
    Psychopharmacology (Berl) 183:154-62. 2005
    ..There is no consensus on the contribution of adenosine A(1) and A(2A) receptor blockade to motor-activating effects of caffeine...
  90. ncbi Endogenous adenosine protects preconditioned heart during early minutes of reperfusion by activating Akt
    Nataliya V Solenkova
    Dept of Physiology, Univ of South Alabama, College of Medicine, Mobile, AL 36688, USA
    Am J Physiol Heart Circ Physiol 290:H441-9. 2006
    ..Although PI3K activity must continue long into the reperfusion phase, adenosine receptor occupancy is no longer needed by 30 min of reperfusion, and ERK activity is only required in the first few minutes of reperfusion...
  91. ncbi Contractile effects of adenosine A1 and A2A receptors in isolated murine hearts
    Eugene I Tikh
    Dept of Physiology, Univ of Massachusetts Medical School, 55 Lake Ave N, Worcester, MA 01655, USA
    Am J Physiol Heart Circ Physiol 290:H348-56. 2006
    ..In addition, A2AR supports myocardial contractility in a setting of low-flow ischemia...
  92. ncbi Combination of adenosine A1 and A2A receptor blocking agents induces caffeine-like locomotor stimulation in mice
    Alexander Kuzmin
    Department of Neuroscience, Karolinska Institutet, Sweden
    Eur Neuropsychopharmacol 16:129-36. 2006
    ..It is hypothesised that the stimulatory effect of low doses of caffeine in C57BL/6J mice is due to concomitant blockade of both A(1) and A(2A) adenosine receptors...
  93. ncbi Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex
    Nelson Rebola
    Center for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Epilepsia 46:159-65. 2005
    ..Since both A1 and A 2A receptors are prone to down- and upregulation in different stressful situations, we investigated if convulsive behavior leads to a long-term change in A1 and A 2A receptor density in the rat cerebral cortex...
  94. ncbi Does conversion of ATP to adenosine terminate ATP-stimulated vasopressin release from hypothalamo-neurohypophyseal explants?
    Zhilin Song
    Department of Physiology and Biophysics, University of Colorado at Denver and Health Sciences Center, PO Box 6511, Mail Stop 8307, Aurora, CO 80045, USA
    Brain Res 1047:105-11. 2005
    ....
  95. ncbi Tonic adenosine A1 and A2A receptor activation is required for the excitatory action of VIP on synaptic transmission in the CA1 area of the hippocampus
    D Cunha-Reis
    Institute of Pharmacology and Neurosciences, Faculty of Medicine and Institute of Molecular Medicine, University of Lisbon, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Neuropharmacology 52:313-20. 2007
    ..This differential sensitivity to adenosine modulation might be due to the different VIP circuits contributing to VIP effects on pyramidal cell dendrites and pyramidal cell bodies...
  96. ncbi Activation of adenosine receptors in the posterior cingulate cortex impairs memory retrieval in the rat
    Grace Schenatto Pereira
    Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS
    Neurobiol Learn Mem 83:217-23. 2005
    ..These findings provide behavioral evidence for the role of adenosinergic system in the memory retrieval into PCC...
  97. ncbi Adenosine agonist regulation of outward active transport of fluorescein across retinal pigment epithelium in rabbits
    Atsushi Kawahara
    Department of Ophthalmology, Asahikawa Medical College, 2 1 Midorigaoka Higashi, Asahikawa 078 8510, Japan
    Exp Eye Res 80:493-9. 2005
    ..02 and 0.05, respectively). Intravitreous injection of high-dose NECA accelerates the active outward transport across the RPE via A1 receptors and low-dose NECA decelerates it via A2 receptors...
  98. ncbi Modulation of short-term social memory in rats by adenosine A1 and A(2A) receptors
    Rui D S Prediger
    Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, UFSC, Florianopolis, SC 88049 900, Brazil
    Neurosci Lett 376:160-5. 2005
    ..These results indicate that adenosine modulates the short-term social memory in rats by acting on both A1 and A(2A) receptors, with adenosine receptor agonists and antagonists, respectively, disrupting and enhancing the social memory...
  99. pmc Role of central and peripheral adenosine receptors in the cardiovascular responses to intraperitoneal injections of adenosine A1 and A2A subtype receptor agonists
    Charles W Schindler
    Preclinical Pharmacology Section, Behavioral Neuroscience Branch, Department of Health and Human Services, National Institutes of Health National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, USA
    Br J Pharmacol 144:642-50. 2005
    ..The blood pressure decreasing effect of adenosine A2A agonists is most probably mediated in the periphery...
  100. ncbi Astrocytic purinergic signaling coordinates synaptic networks
    Olivier Pascual
    Department of Neuroscience, Conte Center for Integration at the Tripartite Synapse, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 310:113-6. 2005
    ..These results indicate that astrocytes are intricately linked in the regulation of synaptic strength and plasticity and provide a pathway for synaptic cross-talk...
  101. ncbi Involvement of adenosinergic A1 systems in the occurrence of respiratory perturbations encountered in newborns following an in utero caffeine exposure. a study on brainstem-spinal cord preparations isolated from newborn rats
    F Saadani-Makki
    Laboratoire de Dysrégulations Métaboliques Acquises et génétiques EA 2088 EA 2629, Faculte de Medecine, 3 rue des Louvels, 80036 Amiens Cedex 1, France
    Neuroscience 127:505-18. 2004
    ....

Research Grants46

  1. STRUCTURE OF ADENOSINE RECEPTORS
    Jack Wells; Fiscal Year: 2002
    ..xanthine-type antagonists occupy the same binding site, and determine the relative orientations of adenosine and xanthines within the binding site...
  2. ADENOSINE RECEPTOR MODULATION OF SEIZURE SUSCEPTIBILITY
    Thomas Murray; Fiscal Year: 1990
    ..c.v.) in rats. The rank order potencies of a series of xanthines, administered i.c.v., as proconvulsants in the PTZ seizure threshold model will also be determined...
  3. DEVELOPMENTAL REGULATION OF HYPERCAPNIC RESPONSES
    Richard Martin; Fiscal Year: 2006
    ..As a consequence large numbers of preterm infants receive therapy with xanthines, although their precise mechanism of action is not clearly understood...
  4. CHROMATIN CONFORMATION AND PLD REPAIR
    Yvonne Taylor; Fiscal Year: 1992
    ..Agents currently known to affect the expression of PLD following ionizing radiation include methylated xanthines, purine nucleoside analogs, nicotinamide analogs, intercalating antibiotics and anisotonic solutions...
  5. CYCLIC AMP/ADENOSINE PATHWAY
    Edwin Jackson; Fiscal Year: 2002
    ..abstract_text> ..
  6. MOTOR EFFECTS OF ATYPICAL ANTIPSYCHOTICS
    John Salamone; Fiscal Year: 2003
    ..Taken together, the results of these experiments will help to identify the pharmacological characteristics and brain circuits that underlie the motor effects of clozapine. ..
  7. Effort-related Functions of Nucleus Accumbens Adenosine A2A Receptors
    John D Salamone; Fiscal Year: 2010
    ....
  8. Dopamine D2 and Adenosine A2A roles:Tremulous Movements
    John Salamone; Fiscal Year: 2007
    ..abstract_text> ..
  9. BEHAVIORAL EFFECTS OF NIGRAL D1 ANTAGONISM
    John Salamone; Fiscal Year: 2001
    ....
  10. HYPOXIA AND CONTROL OF FETAL BREATHING MOVEMENTS
    Brian J Koos; Fiscal Year: 2010
    ..Thus, the proposed studies are directly applicable to the morbidity and mortality of heart and breathing disorders in infants, children, and adults, including prolonged sleep apnea, brain injury, and sudden death. ..
  11. NO AND OXIDATIVE STRESS IN HUMAN MYOCARDIAL FAILURE
    Michael Givertz; Fiscal Year: 2003
    ..abstract_text> ..
  12. ELECTROPHYSIOLOGY & PHARMACOLOGY OF SLEEP-WAKEFULNESS
    Mahesh Thakkar; Fiscal Year: 2004
    ..Preliminary data suggest a strong suppressive effect of microdialysis-applied 8-OH-DPAT on state-related discharge activity of the dorsal raphe nucleus, and we will also investigate the effects of 5HT1A antagonists. ..
  13. Chitosan as a pore former in coated beads for colon specific drug delivery
    STEVEN NEAU; Fiscal Year: 2008
    ..If the goals of this project are achieved, then lower doses can be administered with the therapeutic benefits of more effective treatment and far lower incidences of systemic side effects. [unreadable] [unreadable] [unreadable]..
  14. Micellar VIP Nanoparticles for Rheumatoid Arthritis
    Israel Rubinstein; Fiscal Year: 2007
    ..abstract_text> ..
  15. Natural History of Attempts to Stop Smoking
    John R Hughes; Fiscal Year: 2010
    ....
  16. Gradual vs Abrupt Cessation Treatment for Smoking
    John Hughes; Fiscal Year: 2007
    ..This study will be the first large, systematic test of gradual vs. abrupt cessation. ..
  17. CHEMOTRANSDUCTION IN THE CAROTID BODY
    Robert Fitzgerald; Fiscal Year: 2007
    ..Medical management of these situations could be greatly improved with a better understanding of the CB's transductive processes, possibly with genetic manipulation or drugs with highly focused effects. ..
  18. Internal Barriers to Seeking Smoking Cessation Treatment
    John Hughes; Fiscal Year: 2007
    ..Our results will suggest messages for media campaigns and for clinicians to use to motivate smokers to access proven treatments. ..
  19. Regulation of Hypothalamic Sleep-wake Neuronal System
    NOOR ALAM; Fiscal Year: 2008
    ..This will contribute to the search for more targeted and specific therapeutic strategies for sleep disorders. ..
  20. Adenosinergic Mechanisms of Intrauterine Growth Retardation
    Scott A Rivkees; Fiscal Year: 2010
    ..The goals of this proposal are to identify the mechanisms by which adenosine acts to protect the embryo in utero and how altered embryonic adenosine action leads to long-term adverse effects in adulthood. ..
  21. Dissection of Ethanol Actions on Cholinergic Nerve Endings
    TIMOTHY SEARL; Fiscal Year: 2008
    ..Our preliminary data with botulinums toxins demonstrate that the synaptic vesicle protein synaptobrevin is an important target for the effects of ethanol. [unreadable] [unreadable] [unreadable] [unreadable]..
  22. Vessel Remodeling During Ductus Arteriosus Closure
    Ronald I Clyman; Fiscal Year: 2010
    ..These studies should increase our understanding of the mechanisms that prevent the preterm DA from closing and remodeling after birth. ..
  23. Effect of Drugs on Myocardial Hypoxia
    Garrett Gross; Fiscal Year: 2009
    ..Information gained from these studies will hopefully lead to new therapies to treat patients with ischemic heart disease. ..
  24. Mechanism and in vivo anti-HBV study of a novel class of non-nucleoside compounds
    Yung Chi Cheng; Fiscal Year: 2010
    ..The studies proposed will provide information about not only the potential of the novel compound 8-1, as an anti-HBV drug, but also the roles of liver enriched transcription factors in regulation of HBV transcription. ..
  25. ACTION - A CHF Trial Investigating Outcomes of Exercise
    CHRISTOPHER O CONNOR; Fiscal Year: 2008
    ..The trial will take place over 5 years with an initial 6 months for planning, training, and implementation; 3 years of enrollment; 1 year of follow-up; and 6 months for close out, analysis, and presentation. ..
  26. Radioactive Iodide Therapy of Pediatric Graves' Disease
    Scott A Rivkees; Fiscal Year: 2010
    ....
  27. A3 Adenosine Receptors Cardioprotective Mechanisms
    John Auchampach; Fiscal Year: 2007
    ..The results of theses studies should also provide new insights into the therapeutic utility of targeting A3ARs in patients with ischemic heart disease. ..
  28. EVALUATION OF A CIGARETTE SUBSTITUTE
    John Hughes; Fiscal Year: 2001
    ..We believe it imperative to begin studying these substitutes so that, unlike low-tar/low nicotine cigarettes, we will know whether their introduction is good or bad for public health. ..
  29. REGULATION OF MACROPHAGE DEPENDENT ANGIOGENIC ACTIVITY
    SAMUEL LEIBOVICH; Fiscal Year: 2002
    ..abstract_text> ..
  30. DEVELOPING CIRCADIAN RHYTHMICITY
    Scott Rivkees; Fiscal Year: 2002
    ..These studies may also lead to the development of new care practices in Neonatal Intensive Care Units and extend the field of developmental chronobiology to the bedside. ..
  31. Resolutions in Branched Alkanes using Lipase in Beads
    STEVEN NEAU; Fiscal Year: 2002
    ..The stability of the bead, the efficiency of the lipase entrapment, and the reduction in lipase activity as a function of repeated applications will also be evaluated in the third study. ..
  32. CONTROL OF SLEEP AND AROUSAL
    NOOR ALAM; Fiscal Year: 2003
    ..These pharmacological manipulations and analytical procedures will help understanding of the adenosinergic and GABAergic mechanisms that shape the discharge patterns of the MBF neurons across the sleep-waking cycle. ..
  33. A1-ADENOSINE RECEPTOR ACTION IN HIPPOCAMPUS
    Scott Rivkees; Fiscal Year: 2003
    ..We anticipate these studies will lead to new insights into the mechanisms of A1AR action. We also anticipate that these studies will identify A1ARs as an important regulator of axon growth. ..
  34. Vaccine therapy of congenital adrenal Hyperplasia
    Scott Rivkees; Fiscal Year: 2003
    ..We also anticipate being able to extend this novel approach to the treatment of other receptor-mediated endocrine disorders, such as hyperthyroidism. ..
  35. TNF-ALPHA REGULATION OF AT1 RECEPTOR & POST-MI FIBROSIS
    Barry Greenberg; Fiscal Year: 2003
    ..This information will provide important insights into the pathogenesis of post-MI fibrosis. ..
  36. The Role of Adenosine in Hypoglycemic Brain Injury
    Scott Rivkees; Fiscal Year: 2003
    ..We anticipate that these studies will yield new insights into the mechanisms of hypoglycemic brain injury and may lead to the development of practical strategies for reducing hypoglycemic brain injury. ..
  37. Anti-Adenosine Therapy of Neonatal Brain Injury
    Scott Rivkees; Fiscal Year: 2007
    ..It is anticipated that these studies will lead to novel and practical strategies for directly preventing brain injury. [unreadable] [unreadable]..
  38. A-1 Adenosine Receptor Action in Developing Heart
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will identify Rho and ROCK as critical signaling molecules in heart development and reveal that cardiac GTPase activity transduces the effects of adenosine. ..
  39. PRESERVATION OF GENETIC LINES IN A NON MAMMALIAN SYSTEM
    Mary Hagedorn; Fiscal Year: 2005
    ..Most importantly, these somatic changes will not affect the germ line, so they are ideal for genomic banking to maintain important genetic stocks for biomedical and endangered fish research. ..
  40. V & Q Disturbances in Obliterative Bronchiolitis
    David Lipson; Fiscal Year: 2005
    ..abstract_text> ..
  41. Drug-Induced Motor Recovery After Spinal Cord Injury
    Kwaku Nantwi; Fiscal Year: 2005
    ..abstract_text> ..
  42. CB1 Receptor Action on the Developing Hippocampus
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will result in new insights into the potential effects of cannabinoid action on the developing brain. ..
  43. Regulation of spinal NK1R expression by chronic stress
    Sylvie Bradesi; Fiscal Year: 2006
    ..This proposal is expected to provide new insights into the mechanisms by which stress affects the processing of visceral nociception. ..
  44. NUCLEOSIDE ANALOGS AS ANTICANCER COMPOUNDS
    Yung Chi Cheng; Fiscal Year: 2007
    ..It should yield novel information for understanding the biochemical determinants of the action of L-OddC, the biochemistry of the enzymes studied and possible novel use of L-OddC for the treatment of solid tumor. ..
  45. ROS Defense Mechanisms in Brain Reoxygenation
    Sarah Milton; Fiscal Year: 2004
    ....