allopurinol

Summary

Summary: A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.

Top Publications

  1. ncbi Allopurinol is the most common cause of Stevens-Johnson syndrome and toxic epidermal necrolysis in Europe and Israel
    Sima Halevy
    Department of Dermatology, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Am Acad Dermatol 58:25-32. 2008
  2. pmc Effect of allopurinol in chronic kidney disease progression and cardiovascular risk
    Marian Goicoechea
    Servicio de Nefrologia, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Clin J Am Soc Nephrol 5:1388-93. 2010
  3. ncbi Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level
    Yui Pong Siu
    Division of Nephrology, Department of Medicine, Tuen Mun Hospital, Hong Kong, China
    Am J Kidney Dis 47:51-9. 2006
  4. pmc Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial
    Daniel I Feig
    Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX 77030, USA
    JAMA 300:924-32. 2008
  5. pmc A randomized study of allopurinol on endothelial function and estimated glomular filtration rate in asymptomatic hyperuricemic subjects with normal renal function
    Mehmet Kanbay
    Alparslan Mahallesi, Umit sokak, No 25 14, Melikgazi, Kayseri, Turkey
    Clin J Am Soc Nephrol 6:1887-94. 2011
  6. ncbi Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis
    Pamela Gasse
    University of Orleans and CNRS, Orleans, France
    Am J Respir Crit Care Med 179:903-13. 2009
  7. ncbi Effect of treatment of hyperuricemia with allopurinol on blood pressure, creatinine clearence, and proteinuria in patients with normal renal functions
    Mehmet Kanbay
    35 Sokak, 81 5, Bahcelievler, Ankara, 06490, Turkey
    Int Urol Nephrol 39:1227-33. 2007
  8. pmc The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial
    Michael A Becker
    The University of Chicago Pritzker School of Medicine, MC0930, University of Chicago Medical Center, 5841 S, Maryland Avenue, Chicago, IL 60637, USA
    Arthritis Res Ther 12:R63. 2010
  9. ncbi Mechanistic insights into the therapeutic use of high-dose allopurinol in angina pectoris
    Narasimharajapura S Rajendra
    Division of Medical Sciences, University of Dundee, Ninewells Hospital Medical School, Dundee, UK
    J Am Coll Cardiol 58:820-8. 2011
  10. pmc N-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats
    Tingting Wang
    Department of Anaesthesiology, The University of Hong Kong, Hong Kong SAR, China
    PLoS ONE 6:e23967. 2011

Detail Information

Publications324 found, 100 shown here

  1. ncbi Allopurinol is the most common cause of Stevens-Johnson syndrome and toxic epidermal necrolysis in Europe and Israel
    Sima Halevy
    Department of Dermatology, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Am Acad Dermatol 58:25-32. 2008
    ..Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare severe cutaneous adverse reactions...
  2. pmc Effect of allopurinol in chronic kidney disease progression and cardiovascular risk
    Marian Goicoechea
    Servicio de Nefrologia, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Clin J Am Soc Nephrol 5:1388-93. 2010
    Hyperuricemia is associated with hypertension, inflammation, renal disease progression, and cardiovascular disease. However, no data are available regarding the effect of allopurinol in patients with chronic kidney disease.
  3. ncbi Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level
    Yui Pong Siu
    Division of Nephrology, Department of Medicine, Tuen Mun Hospital, Hong Kong, China
    Am J Kidney Dis 47:51-9. 2006
    Hyperuricemia is associated strongly with the development of hypertension, renal disease, and progression. Allopurinol decreases serum uric acid levels by inhibiting the enzyme xanthine oxidase...
  4. pmc Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial
    Daniel I Feig
    Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX 77030, USA
    JAMA 300:924-32. 2008
    ..Experimentally increasing uric acid levels using a uricase inhibitor causes systemic hypertension in animal models...
  5. pmc A randomized study of allopurinol on endothelial function and estimated glomular filtration rate in asymptomatic hyperuricemic subjects with normal renal function
    Mehmet Kanbay
    Alparslan Mahallesi, Umit sokak, No 25 14, Melikgazi, Kayseri, Turkey
    Clin J Am Soc Nephrol 6:1887-94. 2011
    ..We hypothesized that lowering uric acid in subjects with asymptomatic hyperuricemia with allopurinol might improve endothelial dysfunction, BP, estimated GFR (eGFR), and inflammatory markers.
  6. ncbi Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis
    Pamela Gasse
    University of Orleans and CNRS, Orleans, France
    Am J Respir Crit Care Med 179:903-13. 2009
    ..The molecular mechanisms by which lung injury triggers IL-1beta production, inflammation, and fibrosis remain poorly understood...
  7. ncbi Effect of treatment of hyperuricemia with allopurinol on blood pressure, creatinine clearence, and proteinuria in patients with normal renal functions
    Mehmet Kanbay
    35 Sokak, 81 5, Bahcelievler, Ankara, 06490, Turkey
    Int Urol Nephrol 39:1227-33. 2007
    ..We therefore conducted a prospective study to investigate the benefits of allopurinol treatment in hyperuricemic patients with normal renal function.
  8. pmc The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial
    Michael A Becker
    The University of Chicago Pritzker School of Medicine, MC0930, University of Chicago Medical Center, 5841 S, Maryland Avenue, Chicago, IL 60637, USA
    Arthritis Res Ther 12:R63. 2010
    The purpose of this study was to compare urate-lowering (UL) efficacy and safety of daily febuxostat and allopurinol in subjects with gout and serum urate (sUA) > or = 8.0 mg/dL in a six-month trial.
  9. ncbi Mechanistic insights into the therapeutic use of high-dose allopurinol in angina pectoris
    Narasimharajapura S Rajendra
    Division of Medical Sciences, University of Dundee, Ninewells Hospital Medical School, Dundee, UK
    J Am Coll Cardiol 58:820-8. 2011
    The aim of this study was to evaluate the effect of high-dose allopurinol on vascular oxidative stress (OS) and endothelial function in subjects with stable coronary artery disease (CAD).
  10. pmc N-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats
    Tingting Wang
    Department of Anaesthesiology, The University of Hong Kong, Hong Kong SAR, China
    PLoS ONE 6:e23967. 2011
    ..It is unknown whether or not antioxidant treatment with N-acetylcysteine (NAC) and/or allopurinol (ALP) can attenuate APN deficiency and myocardial ischemia reperfusion (MI/R) injury in the early stage of ..
  11. ncbi Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine
    Miles P Sparrow
    Section of Gastroenterology and Nutrition, University of Chicago Medical Center, Chicago, Illinois, USA
    Clin Gastroenterol Hepatol 5:209-14. 2007
    ..We describe the use of allopurinol in AZA/6-MP nonresponders to deliberately shunt metabolism of 6-MP toward 6-thioguanine (6-TGN) and improve ..
  12. ncbi Meta-analysis: allopurinol in the prevention of postendoscopic retrograde cholangiopancreatography pancreatitis
    Y Bai
    Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China
    Aliment Pharmacol Ther 28:557-64. 2008
    Several clinical trials evaluating the prophylactic effect of allopurinol on postendoscopic retrograde cholangiopancreatography (ERCP) pancreatitis have been published; however, there is no consensus on whether prophylactic allopurinol ..
  13. ncbi Strong association between HLA-B*5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population
    Wichittra Tassaneeyakul
    Departments of Pharmacology, Khon Kaen University, Khon Kaen, Thailand
    Pharmacogenet Genomics 19:704-9. 2009
    b>Allopurinol, a uric acid lowering drug commonly used for hyperuricemia and gouty arthritis, has been reported as a common cause of severe cutaneous adverse drug reactions (SCAR) including Stevens-Johnson syndrome (SJS) and toxic ..
  14. ncbi Xanthine oxidase is involved in free radical production in type 1 diabetes: protection by allopurinol
    Marí Carmen Desco
    Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Diabetes 51:1118-24. 2002
    ..This is completely inhibited by allopurinol, an inhibitor of xanthine oxidase...
  15. ncbi High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid
    Jacob George
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Circulation 114:2508-16. 2006
    b>Allopurinol has been shown to improve endothelial function in chronic heart failure. This study aimed to establish its mechanism of action and to construct a dose-response curve for the effect of allopurinol.
  16. pmc HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
    Shuen Iu Hung
    Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    Proc Natl Acad Sci U S A 102:4134-9. 2005
    b>Allopurinol, a commonly prescribed medication for gout and hyperuricemia, is a frequent cause of severe cutaneous adverse reactions (SCAR), which include the drug hypersensitivity syndrome, Stevens-Johnson syndrome, and toxic epidermal ..
  17. pmc Gout epidemiology: results from the UK General Practice Research Database, 1990-1999
    T R Mikuls
    Department of Medicine, University of Nebraska Medical Center and Omaha VA Medical Center, Omaha, NE, USA
    Ann Rheum Dis 64:267-72. 2005
    ..To examine the epidemiology of gout and gout treatment in the United Kingdom using a large national practice based population...
  18. ncbi Effect of long-term and high-dose allopurinol therapy on endothelial function in normotensive diabetic patients
    Ali Dogan
    Department of Cardiology, Erciyes University, Faculty of Medicine, Kayseri, Turkey
    Blood Press 20:182-7. 2011
    ..Xanthine oxidase inhibition with allopurinol decreases uric acid levels and oxidative stress and improves endothelial function...
  19. ncbi Reduction of uric acid levels with allopurinol treatment improves endothelial function in patients with chronic kidney disease
    Berna Yelken
    Department of Internal Medicine, Istanbul University, Istanbul, Turkey
    Clin Nephrol 77:275-82. 2012
    ..In this prospective study, we aimed to evaluate the effects of treatment of hyperuricemia with allopurinol on ED and changes in the serum reactive oxygen species in patients with CKD.
  20. ncbi High-dose allopurinol reduces left ventricular mass in patients with ischemic heart disease
    Sushma Rekhraj
    Division of Cardiovascular and Diabetes Medicine, Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
    J Am Coll Cardiol 61:926-32. 2013
    This study sought to ascertain if high-dose allopurinol regresses left ventricular mass (LVM) in patients with ischemic heart disease (IHD).
  21. pmc Allopurinol benefits left ventricular mass and endothelial dysfunction in chronic kidney disease
    Michelle P Kao
    Division of Medical Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    J Am Soc Nephrol 22:1382-9. 2011
    b>Allopurinol ameliorates endothelial dysfunction and arterial stiffness among patients without chronic kidney disease (CKD), but it is unknown if it has similar effects among patients with CKD...
  22. ncbi N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and PI3K/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes
    Tingting Wang
    Department of Anesthesiology, The University of Hong Kong, Hong Kong SAR, China
    Free Radic Biol Med 63:291-303. 2013
    N-Acetylcysteine (NAC) and allopurinol (ALP) synergistically reduce myocardial ischemia reperfusion (MI/R) injury in diabetes. However, the mechanism is unclear...
  23. ncbi A prospective, randomized, placebo-controlled trial of prednisone and allopurinol in the prevention of ERCP-induced pancreatitis
    A Budzynska
    Dept of Gastroenterology, Silesian Medical Academy, Katowice, Poland
    Endoscopy 33:766-72. 2001
    ..Corticosteroids, potent anti-inflammatory drugs, and allopurinol--a xanthine oxidase inhibitor that blocks the generation of oxygen-derived free radicals--may be potentially ..
  24. pmc Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial
    Awsan Noman
    Division of Medical Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Lancet 375:2161-7. 2010
    ..We ascertained whether high-dose allopurinol prolongs exercise capability in patients with chronic stable angina.
  25. pmc N-acetylcysteine and allopurinol confer synergy in attenuating myocardial ischemia injury via restoring HIF-1α/HO-1 signaling in diabetic rats
    XiaoWen Mao
    Department of Anaesthesiology, University of Hong Kong, Hong Kong, China
    PLoS ONE 8:e68949. 2013
    To determine whether or not the antioxidants N-acetylcysteine (NAC) and allopurinol (ALP) confer synergistic cardioprotection against myocardial ischemia/reperfusion (MI/R) injury by stabilizing hypoxia inducible factor 1α (HIF-1α)/..
  26. ncbi Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats
    Qing Hua Hu
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, PR China
    Biochem Pharmacol 84:113-25. 2012
    ..The restoration of fructose-induced hyperuricemia and dyslipidemia by the treatment of allopurinol, quercetin and rutin blocked the NLRP3 inflammasome activation to improve the signaling impairments and reduce ..
  27. ncbi Allopurinol as a cardiovascular drug
    Anita Kelkar
    Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Cardiol Rev 19:265-71. 2011
    ..Although traditionally the cornerstone therapy for gout, allopurinol's ability to be a competitive inhibitor of the key enzyme, xanthine oxidase, needed for uric acid formation, ..
  28. pmc Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation
    Chuang Wang
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, People s Republic of China
    PLoS ONE 7:e38285. 2012
    ..Although dietary flavonoid quercetin and allopurinol alleviate hyperuricemia, dyslipidmia and inflammation, their nephroprotective effects are currently unknown...
  29. pmc Efficacy of combined therapy with liposome-encapsulated meglumine antimoniate and allopurinol in treatment of canine visceral leishmaniasis
    Sydnei M da Silva
    Departamento de Parasitologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Antimicrob Agents Chemother 56:2858-67. 2012
    ..In order to improve treatment with LMA, the present study aimed to evaluate its efficacy in combination with allopurinol. Mongrel dogs naturally infected with Leishmania infantum were treated with six doses of LMA (6...
  30. ncbi Allopurinol attenuates left ventricular dysfunction in rats with early stages of streptozotocin-induced diabetes
    Xia Gao
    Department of Endocrinology, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, China
    Diabetes Metab Res Rev 28:409-17. 2012
    ..We hypothesized that xanthine oxidase-inhibitor allopurinol (ALP) may decrease hyperglycemia-induced oxidative stress, ameliorate cardiomyocyte hypertrophy and fibrosis, ..
  31. ncbi Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement
    Qing Hua Hu
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China
    Am J Physiol Renal Physiol 297:F1080-91. 2009
    ..Lowering serum uric acid levels with allopurinol, rutin, and quercetin increased the urinary uric acid/creatinine ratio and FE(ur) and attenuated other fructose-..
  32. ncbi Allopurinol hypersensitivity syndrome: a preventable severe cutaneous adverse reaction?
    H Y Lee
    Dermatology Unit, Singapore General Hospital, Outram Road, Singapore 169608
    Singapore Med J 49:384-7. 2008
    b>Allopurinol is a widely-prescribed urate-lowering agent. Allopurinol hypersensitivity syndrome, a severe form of cutaneous adverse reaction, is associated with significant mortality and morbidity...
  33. ncbi Allopurinol in rat chronic pancreatitis: effects on pancreatic stellate cell activation
    Ilker Tasci
    Department of Internal Medicine, Gulhane School of Medicine, Ankara, Turkey
    Pancreas 35:366-71. 2007
    ..We here searched the in vivo effects of allopurinol on PSC activation and its relation to tissue oxidative stress and histological findings in rat CP.
  34. ncbi Serum uric acid as a new player in the development of diabetic nephropathy
    Peter Hovind
    Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, Nordre Ringvej 57, Glostrup, Denmark
    J Ren Nutr 21:124-7. 2011
    ....
  35. ncbi Effects of allopurinol on cardiac function and oxidant stress in chronic intermittent hypoxia
    Antoinette L Williams
    Department of Medicine, University of South Carolina School of Medicine, Columbia, SC, USA
    Sleep Breath 14:51-7. 2010
    Obstructive sleep apnea is associated with left ventricular (LV) dysfunction, oxidant stress, and chronic intermittent hypoxia (CIH). Allopurinol (ALLO) is a xanthine oxidase inhibitor that also scavenges free radicals.
  36. ncbi Meta-analysis of prophylactic allopurinol use in post-endoscopic retrograde cholangiopancreatography pancreatitis
    Minghua Zheng
    Department of Infection and Liver Diseases, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China
    Pancreas 37:247-53. 2008
    The aim of this study was to evaluate the effectiveness and the safety of allopurinol in the prophylaxis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis.
  37. ncbi Apoptosis versus necrosis during cold storage and rewarming of human renal proximal tubular cells
    A K Salahudeen
    Department of Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA
    Transplantation 72:798-804. 2001
    ..Inclusion of antioxidants in the storage solution confers protection against both cold storage and rewarming-induced necrosis and apoptosis...
  38. ncbi Mechanism and prevention of cold storage-induced human renal tubular cell injury
    A K Salahudeen
    Department of Medicine, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Transplantation 70:1424-31. 2000
    ..The objective was, therefore, to seek direct evidence for the free radical production during the cold storage of human renal tubular cells, and to define the roles of extrinsic and intrinsic antioxidants in cold-induced cell injury...
  39. ncbi Gout, allopurinol use, and heart failure outcomes
    George Thanassoulis
    Department of Medicine, McGill University Health Center, 687 Pine Ave W, Room A4 23, Montreal, QC H3A 1A1, Canada
    Arch Intern Med 170:1358-64. 2010
    ..A recent randomized trial suggested that allopurinol may reduce adverse outcomes among patients with hyperuricemia and HF...
  40. ncbi Real-time PCR in dogs treated for leishmaniasis with allopurinol
    M G Pennisi
    Department of Veterinary Medical Science, Faculty of Veterinary Medicine, University of Messina, Polo Universitario dell Annunziata, 98168, Messina, Italy
    Vet Res Commun 29:301-3. 2005
  41. ncbi Prevalence of contraindications and prescription of pharmacologic therapies for gout
    Robert T Keenan
    Section of Rheumatology of the New York Harbor Health Care System, New York Campus of the US Department of Veterans Affairs, New York, USA
    Am J Med 124:155-63. 2011
    ..Patients with gout have comorbidities, but the impact of these comorbidities on treatment has not been studied...
  42. ncbi Mechanism of free radical production in exhaustive exercise in humans and rats; role of xanthine oxidase and protection by allopurinol
    J Vina
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Valencia
    IUBMB Life 49:539-44. 2000
    ..caused an increase in blood xanthine oxidase activity in rats but also that inhibiting xanthine oxidase with allopurinol prevented exercise-induced oxidation of glutathione in both rats and in humans...
  43. ncbi Allopurinol improves endothelial dysfunction in chronic heart failure
    Colin A J Farquharson
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
    Circulation 106:221-6. 2002
    ..Xanthine oxidase produces oxidative stress and therefore we examined whether allopurinol improved endothelial dysfunction in chronic heart failure.
  44. pmc Impact of allopurinol use on urate concentration and cardiovascular outcome
    Li Wei
    Medicines Monitoring Unit MEMO, Division of Medical Sciences, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Br J Clin Pharmacol 71:600-7. 2011
    To characterize patients with urate measurements by urate-lowering therapy (ULT) use and to study the impact of allopurinol treatment on cardiovascular and mortality outcomes.
  45. ncbi Suboptimal physician adherence to quality indicators for the management of gout and asymptomatic hyperuricaemia: results from the UK General Practice Research Database (GPRD)
    T R Mikuls
    Department of Medicine, Division of Clinical Immunology and Rheumatology, 510 20th Street South, FOT 8th Floor, Birmingham, AL 35294, USA
    Rheumatology (Oxford) 44:1038-42. 2005
    To examine adherence to validated quality indicators assessing the quality of allopurinol use in the treatment of gout and asymptomatic hyperuricaemia.
  46. ncbi Treatment of chronic gout. Can we determine when urate stores are depleted enough to prevent attacks of gout?
    J Li-Yu
    Department of Medicine, Hospital of the University of Pennsylvania, USA
    J Rheumatol 28:577-80. 2001
    ..To determine if lowering of serum uric acid (SUA) concentrations below 6 mg/dl or longer duration of lowered SUA will result in depletion of urate crystals from the knee joints and prevent further attacks of gout...
  47. pmc Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol
    Pal Pacher
    Laboratory of Physiological Studies, National Institute on Alcohol Aabuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane MSC 9413, Room 2N 17, Bethesda, Maryland 20892 9413, USA
    Pharmacol Rev 58:87-114. 2006
    The prototypical xanthine oxidase (XO) inhibitor allopurinol, has been the cornerstone of the clinical management of gout and conditions associated with hyperuricemia for several decades...
  48. pmc Concordance of the management of chronic gout in a UK primary-care population with the EULAR gout recommendations
    Edward Roddy
    Academic Rheumatology, University of Nottingham, UK
    Ann Rheum Dis 66:1311-5. 2007
    ..To assess concordance of the management of chronic gout in UK primary care with the European League Against Rheumatism (EULAR) gout recommendations...
  49. ncbi Uric acid lowering therapy: prescribing patterns in a large cohort of older adults
    D H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    Ann Rheum Dis 67:609-13. 2008
    ..Uric acid lowering therapy (UALT) is considered a chronic treatment for gout. Relatively little is known about adherence to UALT...
  50. ncbi Determinants of the clinical outcomes of gout during the first year of urate-lowering therapy
    Michael A Becker
    Rheumatology Section, Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA
    Nucleosides Nucleotides Nucleic Acids 27:585-91. 2008
    ..The complex relationship between urate-lowering and clinical outcome early in treatment has implications for both clinical and investigative approaches to urate-lowering management...
  51. ncbi Oxidative stress in distant organs and the effects of allopurinol during experimental acute pancreatitis
    L Czako
    First Department of Medicine, Albert Szent Gyorgyi Medical University, Attila Jozsef University, Szeged, Hungary
    Int J Pancreatol 27:209-16. 2000
    ..the role of oxygen-derived free radicals in the development of local and systemic manifestations of L-arginine (Arg)-induced acute pancreatitis and at an evaluation of the protective effect of the xanthine oxidase inhibitor allopurinol.
  52. ncbi Allopurinol attenuates L-NAME induced cardiomyopathy comparable to blockade of angiotensin receptor
    D A B Kasal
    Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, Rio de Janeiro, Brazil
    Histol Histopathol 23:1241-8. 2008
    ..The aim of this study was to evaluate the contribution of xanthine oxidase (XO) to these phenomena using allopurinol, isolated or associated with olmesartan...
  53. ncbi Effects of the anti-ICAM-1 monoclonal antibody, allopurinol, and methylene blue on intestinal reperfusion injury
    Huseyin Ilhan
    Department of Pediatric Surgery, Osmangazi University, School of Medicine, Eskisehir, Turkey
    J Pediatr Surg 38:1591-5. 2003
    The aim of this study was to evaluate the effect of allopurinol, methylene blue, and a monoclonal antibody to the adhesion molecule ICAM-1 in intestinal ischemia and reperfusion injury.
  54. ncbi Hypothermic storage of isolated human hepatocytes: a comparison between University of Wisconsin solution and a hypothermosol platform
    Alina Ostrowska
    Wroclaw University of Environmental and Life Sciences, Wrocław, Poland
    Arch Toxicol 83:493-502. 2009
    ..Moreover, the use of HTS-FRS eliminates the need for serum in preservation solutions. HTS-FRS represents an improved solution compared to HTS-Base and UW for extending the shipping/storage time of human hepatocytes...
  55. pmc Clinical Pharmacogenetics Implementation Consortium guidelines for human leukocyte antigen-B genotype and allopurinol dosing
    M S Hershfield
    Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA
    Clin Pharmacol Ther 93:153-8. 2013
    b>Allopurinol is the most commonly used drug for the treatment of hyperuricemia and gout...
  56. ncbi Allopurinol and xanthine use different translocation mechanisms and trajectories in the fungal UapA transporter
    George Diallinas
    Faculty of Biology, Department of Botany, University of Athens, Panepistimioupolis, Athens 15784, Greece
    Biochimie 95:1755-64. 2013
    ..Here, genetic and physiological evidence is provided showing that allopurinol is a high-affinity, low-capacity, substrate for UapA...
  57. ncbi Effects of allopurinol on coronary microvascular and left ventricular function in patients with idiopathic dilated cardiomyopathy
    Dogan Erdogan
    Suleyman Demirel University, Faculty of Medicine, Cardiology Department, Isparta, Turkey
    Can J Cardiol 28:721-7. 2012
    ..The present study aimed to investigate the effect of allopurinol on left ventricular (LV) function and coronary microvascular integrity in patients with idiopathic dilated ..
  58. pmc Experimental small bowel preservation using Polysol: a new alternative to University of Wisconsin solution, Celsior and histidine-tryptophan-ketoglutarate solution?
    Lai Wei
    House of Experimental Therapy, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    World J Gastroenterol 13:3684-91. 2007
    ....
  59. ncbi Changes in uric acid levels and allopurinol use in chronic heart failure: association with improved survival
    Israel Gotsman
    Heart Institute, Hadassah University Hospital, Jerusalem, Israel
    J Card Fail 18:694-701. 2012
    ..We evaluated the effect of UA and allopurinol use on clinical outcome in patients with HF.
  60. pmc Sequential combined treatment with allopurinol and benznidazole in the chronic phase of Trypanosoma cruzi infection: a pilot study
    D E Perez-Mazliah
    Instituto Nacional de Parasitologia Dr Mario Fatala Chaben, Av Paseo Colon 568, Buenos Aires 1063, Argentina
    J Antimicrob Chemother 68:424-37. 2013
    ..Herein, a pilot study was conducted to evaluate the tolerance and side effects of a sequential combined treatment of two antiparasitic drugs, allopurinol and benznidazole, in the chronic phase of Trypanosoma cruzi infection.
  61. ncbi Does allopurinol prevent post endoscopic retrograde cholangio- pancreatography pancreatitis? A randomized double blind trial
    Mohammad Abbasinazari
    Department of Clinical Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Acta Med Iran 49:579-83. 2011
    ..A number of pharmacological agents have been tried for prevention or alleviation of the complication. Allopurinol with free radical scavenger property has been considered as an effective prophylactic agent in some clinical ..
  62. ncbi Early treatment with allopurinol in familial juvenile hyerpuricaemic nephropathy (FJHN) ameliorates the long-term progression of renal disease
    L D Fairbanks
    Purine Research Unit GKT, Guy s Hospital, London, UK
    QJM 95:597-607. 2002
    The efficacy of allopurinol in autosomal dominant familial juvenile hyperuricaemic nephropathy (FJHN) has been disputed.
  63. pmc Infectivity to Phlebotomus perniciosus of dogs naturally parasitized with Leishmania infantum after different treatments
    Guadalupe Miró
    Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    Parasit Vectors 4:52. 2011
    ..most dogs with clinical leishmaniosis are treated with leishmanicides, typically antimonials combined with allopurinol and good clinical recovery is observed in a high number of these dogs...
  64. ncbi Allopurinol hypersensitivity: a systematic review of all published cases, 1950-2012
    Sheena N Ramasamy
    Department of Clinical Pharmacology and Toxicology, St Vincent s Hospital, 390 Victoria Street, Darlinghurst, NSW, 2010, Australia
    Drug Saf 36:953-80. 2013
    b>Allopurinol is the primary therapy for the management of chronic gout. Utilization of allopurinol has increased in tandem with the growing prevalence of gout globally...
  65. ncbi Apocynin but not allopurinol prevents and reverses adrenocorticotropic hormone-induced hypertension in the rat
    Yi Zhang
    High Blood Pressure Research Unit, John Curtin School of Medical Research, Australian National University, Australian Capital Territory, Canberra, Australia
    Am J Hypertens 18:910-6. 2005
    ..Adrenocorticotropic hormone (ACTH)-induced hypertension in the rat is accompanied by increased oxidative stress. This study examines the enzymatic source of reactive oxygen species in ACTH-hypertension...
  66. ncbi Accelerated tissue aging and increased oxidative stress in broiler chickens fed allopurinol
    H Klandorf
    Division of Animal and Veterinary Sciences, West Virginia University, 26506 6108, Morgantown, WV, USA
    Comp Biochem Physiol C Toxicol Pharmacol 129:93-104. 2001
    ..Study 1 was designed to quantitatively manipulate the plasma concentrations of uric acid using hemin and allopurinol while study 2 determined their effects on skin pentosidine, the shear force value of Pectoralis major muscle, ..
  67. ncbi Using allopurinol above the dose based on creatinine clearance is effective and safe in patients with chronic gout, including those with renal impairment
    Lisa K Stamp
    University of Otago, Christchurch, New Zealand
    Arthritis Rheum 63:412-21. 2011
    To determine the efficacy and safety of increasing the allopurinol dose above the proposed creatinine clearance-based dose in patients with gout.
  68. pmc Chronic kidney disease in gout in a managed care setting
    Mahesh J Fuldeore
    OptumInsight, Clinical Services, 22533 Jameson Drive, Calabasas, CA 91302, USA
    BMC Nephrol 12:36. 2011
    To study the prevalence of chronic kidney disease (CKD) and its impact on allopurinol dosing and uric acid control among patients with gout.
  69. ncbi Allopurinol attenuates oxidative stress and cardiac fibrosis in angiotensin II-induced cardiac diastolic dysfunction
    Nan Jia
    Ruijin Hospital, Shanghai Institute of Hypertension, Shanghai Jiao Tong University Medical School, Shanghai, PR China
    Cardiovasc Ther 30:117-23. 2012
    Oxidative stress and fibrosis is implicated in cardiac remodeling and failure. We tested whether allopurinol could decrease myocardial oxidative stress and attenuate cardiac fibrosis and left ventricular diastolic dysfunction in ..
  70. pmc Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress
    Jacob George
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
    Vasc Health Risk Manag 5:265-72. 2009
    ..b>Allopurinol, a xanthine oxidase inhibitor, has been in clinical use for over 40 years in the treatment of chronic gout...
  71. ncbi Reduction of acute cisplatin ototoxicity and nephrotoxicity in rats by oral administration of allopurinol and ebselen
    Eric D Lynch
    Sound Pharmaceuticals, Inc, Research and Development, 4010 Stone Way N, Suite 120, Seattle, WA 98103, USA
    Hear Res 201:81-9. 2005
    ..bolster the innate oxidative stress defenses of the cochlea, we tested individual and combined formulations of allopurinol, a xanthine oxidase inhibitor, and ebselen, a glutathione peroxidase mimic...
  72. ncbi Effect of the treatment with allopurinol on the endothelial function in patients with hyperuricemia
    Gabriela Meléndez-Ramírez
    Department of Magnetic Resonance, Instituto Nacional de Cardiologia, Ignacio Chavez, Mexico City, Mexico
    Endocr Res 37:1-6. 2012
    ..The role of uric acid (UA) on vascular damage is still controversial because previous studies have included patients with other risk factor for ED...
  73. ncbi A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients
    M Tohkin
    Department of Medicinal Safety Science, National Institute of Health Sciences, Tokyo, Japan
    Pharmacogenomics J 13:60-9. 2013
    ..Genetic biomarkers for allopurinol-related SJS/TEN in Japanese were examined in a genome-wide association study in which Japanese patients (n=14) ..
  74. ncbi Trypanosoma brucei: expression of multiple purine transporters prevents the development of allopurinol resistance
    Manal J Natto
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Joseph Black Building, Glasgow G12 8QQ, UK
    Exp Parasitol 109:80-6. 2005
    b>Allopurinol is a hypoxanthine analogue used to treat Leishmania infections that also displays activity against the related parasite Trypanosoma brucei...
  75. ncbi Cold induces catalytic iron release of cytochrome P-450 origin: a critical step in cold storage-induced renal injury
    Hong Huang
    Department of Medicine, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Am J Transplant 2:631-9. 2002
    ..In the clinical setting, sequestering free iron released during cold storage is possible and may prove to be useful in limiting organ injury...
  76. pmc Oral allopurinol to prevent hyperamylasemia and acute pancreatitis after endoscopic retrograde cholangiopancreatography
    Hector Martinez-Torres
    Department of Gastroenterology and Endoscopy, UMAE Hospital de Especialidades del Centro Medico Nacional de Occidente IMSS, Guadalajara, Jalisco, Mexico
    World J Gastroenterol 15:1600-6. 2009
    To assess the efficacy of allopurinol to prevent hyperamylasemia and pancreatitis after endoscopic retrograde cholangiopancreatography (PEP).
  77. ncbi Effects of allopurinol, a xanthine oxidase inhibitor, on renal injury in hypercholesterolemia-induced hypertensive rats
    Mayumi Minami
    Department of Nephrology and Endocrinology, The University of Tokyo, Tokyo Metropolitan Police Hospital, Tokyo, Japan mayuminami aol com
    Blood Press 14:120-5. 2005
    ..is involved in hypercholesterolemia-induced hypertension and renal injury, we examined the effects of allopurinol, a xanthine oxidase inhibitor, on these conditions...
  78. pmc Inhibition of xanthine oxidase reduces oxidative stress and improves skeletal muscle function in response to electrically stimulated isometric contractions in aged mice
    Michael J Ryan
    Laboratory of Muscle Biology and Sarcopenia, Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV 26506, USA
    Free Radic Biol Med 51:38-52. 2011
    ..5mg/day) allopurinol pellet, 7 days before the start of in situ electrically stimulated isometric contractions...
  79. ncbi Allopurinol reduces neointimal hyperplasia in the carotid artery ligation model in spontaneously hypertensive rats
    Yasutaka Yamamoto
    Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science, Yonago, Japan
    Hypertens Res 29:915-21. 2006
    ..The aim of the current study was to investigate whether allopurinol, an inhibitor of xanthine oxidase activity, affects vascular remodeling and vascular smooth muscle cell (VSMC) ..
  80. ncbi Allopurinol-induced DRESS syndrome in an adolescent patient
    Ashvin K Dewan
    Department of Pediatrics, Baylor College of Medicine, Division of Emergency Medicine, Texas Children s Hospital, Houston, Texas 77030, USA
    Pediatr Dermatol 27:270-3. 2010
    ..male patient, with a history of essential hypertension enrolled in an experimental drug protocol using allopurinol, presented to our emergency department with a 10-day history of fever...
  81. pmc Adherence with urate-lowering therapies for the treatment of gout
    Leslie R Harrold
    Department of Medicine, The Meyers Primary Care Institute, Worcester, MA 01605, USA
    Arthritis Res Ther 11:R46. 2009
    ..Adherence to urate-lowering drugs (ULDs) has not been well evaluated among those with gout. Our aim was to assess the level and determinants of non-adherence with ULDs prescribed for gout...
  82. ncbi Allopurinol to prevent pancreatitis after endoscopic retrograde cholangiopancreatography: a randomized placebo-controlled trial
    Joseph Romagnuolo
    Digestive Disease Center, Department of Medicine, Medical University of South Carolina, South Carolina 29425, USA
    Clin Gastroenterol Hepatol 6:465-71; quiz 371. 2008
    ..Animal studies suggest that (single-dose) allopurinol (xanthine oxidase inhibitor with high oral bioavailability and long-lasting active metabolites) may reduce this ..
  83. pmc Role of purine nucleoside phosphorylase in interactions between 2',3'-dideoxyinosine and allopurinol, ganciclovir, or tenofovir
    Adrian S Ray
    Gilead Sciences, Inc, Foster City, California 94404, USA
    Antimicrob Agents Chemother 48:1089-95. 2004
    ..level of systemic exposure to 2',3'-dideoxyinosine (ddI) is increased 40 to 300% when it is coadministered with allopurinol (Allo), ganciclovir (GCV), or tenofovir. However, the mechanism for these drug interactions remains undefined...
  84. ncbi Oral allopurinol does not prevent the frequency or the severity of post-ERCP pancreatitis
    Patrick Mosler
    Indiana University Medical Center, Indianapolis, 46202, USA
    Gastrointest Endosc 62:245-50. 2005
    ..The aim of this trial was to determine whether prophylactic allopurinol, an inhibitor of oxygen-derived free radical production, would reduce the frequency and severity of post-ERCP ..
  85. ncbi Accumulation of crystal deposits in abdominal organs following perfusion with defrosted University of Wisconsin solutions
    Stefan G Tullius
    Department of Surgery, Charite Virchow Clinic, Berlin, Germany
    Am J Transplant 2:627-30. 2002
    ..UW solutions can reach subzero temperatures under commonly used transportation conditions. Under these conditions, visible crystals accumulate and can be detected in abdominal organs of an experimental system...
  86. ncbi [Allopurinol-induced hypersensitivity syndrome resulting in death]
    Sören Laurisch
    Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Med Klin (Munich) 105:262-6. 2010
    The present report describes the case of a 67-year-old patient who developed an allopurinol-induced hypersensitivity syndrome (AHS) with toxic epidermal necrolysis and subsequently died of septic multiorgan failure...
  87. pmc Combination of thiopurines and allopurinol: adverse events and clinical benefit in IBD
    Shail M Govani
    University of Michigan, Department of Internal Medicine, Division of General Medicine, United States
    J Crohns Colitis 4:444-9. 2010
    b>Allopurinol has been presented as a safe and effective adjunct to thiopurine therapy in inflammatory bowel disease (IBD)...
  88. ncbi Follow-up of Leishmania infantum naturally infected dogs treated with allopurinol: immunofluorescence antibody test, ELISA and Western blot
    Francis Vercammen
    Veterinary Department, Institute of Tropical Medicine, Nationalestraat 155, B 2000, Antwerp, Belgium
    Acta Trop 84:175-81. 2002
    Fourteen dogs naturally infected with Leishmania infantum and treated with allopurinol were monitored clinically and serologically with immunofluorescent antibody test (IFAT, amastigotes and promastigotes), enzyme linked-immunosorbent-..
  89. ncbi Impact of pancreatic cold preservation on rat islet recovery and function
    Antonello Pileggi
    Cell Transplant Center, Diabetes Research Institute, University of Miami Leonard M Miller School of Medicine, Miami, FL 33136, USA
    Transplantation 87:1442-50. 2009
    ..Islet transplantation success depends on the number and quality of islets transplanted. This study aimed at exploring the molecular mechanisms associated with cold pancreas preservation and their impact on islet cell survival and function...
  90. ncbi Allopurinol improves cardiac dysfunction after ischemia-reperfusion via reduction of oxidative stress in isolated perfused rat hearts
    Yoshiharu Kinugasa
    Department of Cardiovascular Medicine, Faculty of Medicine, Tottori University, Yonago, Japan
    Circ J 67:781-7. 2003
    It has been reported that the xanthine oxidase inhibitor, allopurinol, has a protective effect on ischemia - reperfusion injury, but the precise mechanism of its action is still unclear...
  91. ncbi Association between allopurinol and mortality in heart failure patients: a long-term follow-up study
    L Wei
    Medicines Monitoring Unit MEMO, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
    Int J Clin Pract 63:1327-33. 2009
    The aim of the study was to explore the long-term effect of allopurinol on mortality and cardiovascular hospitalisations in heart failure (HF) patients.
  92. ncbi Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans
    Hye Ryun Kang
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Pharmacogenet Genomics 21:303-7. 2011
    Recent investigations suggest genetic susceptibility of allopurinol-induced severe cutaneous adverse reactions (SCARs). However, the strength of association was variable according to phenotypes and ethnic backgrounds...
  93. ncbi Interferon-gamma (INF-gamma), IL4 expression levels and Leishmania DNA load as prognostic markers for monitoring response to treatment of leishmaniotic dogs with miltefosine and allopurinol
    Laura Manna
    Dipartimento di Scienze Cliniche Veterinarie, Universita di Napoli Federico II, Via F Delpino, N 1, 80137 Napoli, Italy
    Cytokine 44:288-92. 2008
    ..in the tissues of Leishmaniainfantum naturally infected dogs and the efficacy of treatment with miltefosine and allopurinol. To this purpose, we exploited a real-time PCR system to detect Leishmania load and the expression levels of ..
  94. ncbi Multicentric, controlled clinical study to evaluate effectiveness and safety of miltefosine and allopurinol for canine leishmaniosis
    Guadalupe Miró
    Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    Vet Dermatol 20:397-404. 2009
    The aim of this trial was to evaluate the effectiveness and safety of miltefosine-allopurinol combination therapy vs. the current reference combination therapy, meglumine antimoniate-allopurinol, for canine leishmaniosis...
  95. ncbi Effects of allopurinol treatment on the progression of chronic nephritis in Canine leishmaniosis (Leishmania infantum)
    K Plevraki
    Clinic of Companion Animal Medicine, School of Veterinary Medicine, Aristotle University of Thessaloniki, Greece
    J Vet Intern Med 20:228-33. 2006
    ..dogs with canine leishmaniosis (CL) participated in this study, which was designed to investigate the effect of allopurinol on the progression of the renal lesions associated with this disease. The animals were allocated into 5 groups...
  96. ncbi Characterization of circulating lymphocyte subpopulations in canine leishmaniasis throughout treatment with antimonials and allopurinol
    Sonia Miranda
    Departament de Medicina i Cirurgia Animals, Universitat Autonoma de Barcelona, Spain
    Vet Parasitol 144:251-60. 2007
    ..with CL and submitted to conventional treatment with meglumine antimoniate (Glucantime) for 1 month and with allopurinol (Zyloric) for 1 year, in order to evaluate the usefulness of these parameters as indicators of the ..
  97. ncbi Study of efficacy of miltefosine and allopurinol in dogs with leishmaniosis
    Laura Manna
    Dipartimento di Scienze Cliniche Veterinarie, Universita di Napoli Federico II, Napoli, Italy
    Vet J 182:441-5. 2009
    ..The aim of this study was to evaluate the efficacy of miltefosine and allopurinol for the control of human leishmaniosis using the dog as a model...
  98. ncbi HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis
    Nahoko Kaniwa
    Division of Medicinal Safety Science, National Institute of Health Sciences, 1 18 11 Kamiyoga, Setagaya Ku, Tokyo
    Pharmacogenomics 9:1617-22. 2008
    ..Recently, strong associations of HLA-B*1502 and HLA-B*5801 with carbamazepine- and allopurinol-induced severe cutaneous adverse reactions were found in Han Chinese patients, respectively, but ethnic ..
  99. ncbi Human leukocyte antigens and drug hypersensitivity
    Wen Hung Chung
    Molecular Medicine Program of Taiwan International Graduate Program, Institute of Biomedical Sciences, Academia Sinica and School of Life Sciences, National Yang Ming University, Taipei, Taiwan
    Curr Opin Allergy Clin Immunol 7:317-23. 2007
    ..The present article reviews the recent literature on the identification of human leukocyte antigen (HLA) alleles as major susceptible genes for drug hypersensitivity and discusses the clinical implications...
  100. ncbi Successful treatment of non-healing cases of cutaneous leishmaniasis, using a combination of meglumine antimoniate plus allopurinol
    Ali Z Momeni
    Aminjavaheri Medical Lab P O Box 1191, 81465 Isfahan, Iran
    Eur J Dermatol 13:40-3. 2003
    ..Recently strains resistant to these drugs have been reported. Allopurinol (AL) has also been suggested for treatment of CL...
  101. ncbi Thiazide diuretics exacerbate fructose-induced metabolic syndrome
    Sirirat Reungjui
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida, USA
    J Am Soc Nephrol 18:2724-31. 2007
    ..Potassium supplementation improves their insulin resistance and hypertension, whereas allopurinol reduces serum levels of uric acid and ameliorates hypertension, hypertriglyceridemia, hyperglycemia, and ..

Research Grants62

  1. Pharmacologic Interventions for Cardiovascular Disease in Obstructive Sleep Apnea
    Barbara J Morgan; Fiscal Year: 2013
    ..application are: 1) Determine if treatment with losartan, an angiotensin type I receptor (AT1R) antagonist, or allopurinol, a XO inhibitor, normalize chemoreflex control of sympathetic outflow and ventilation and improve local ..
  2. A multicenter clinical trial of allopurinol to prevent GFR loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2012
    ..placebo- controlled, randomized clinical trial to evaluate the efficacy of the urate-lowering drug allopurinol, as compared to placebo, in reducing kidney function loss among subjects with T1D...
  3. Design of a Multicenter Clinical Trial of Allopurinol to Prevent GFR Loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2011
    ..double- blind, placebo-controlled, randomized clinical trial evaluating the efficacy of the urate-lowering drug allopurinol, as compared to placebo, in reducing kidney function loss among subjects with T1D...
  4. PERL: A multicenter clinical trial of allopurinol to prevent GFR loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2013
    ..randomized clinical trial with the specific aim of evaluating the efficacy of the urate-lowering drug allopurinol, as compared to placebo, in reducing kidney function loss among subjects with T1D...
  5. Local Vasoconstriction in Postural Tachycardia Syndrome
    Julian M Stewart; Fiscal Year: 2013
    ..measure Ang-II and Ang-(1-7) in the skin, and to examine the effects of NADPH oxidase/XO blockade with apocynin/allopurinol, and superoxide/H2O2 reduction with tempol/ebselen...
  6. MODifiable Effectors of Renin System Activation: Treatment Evaluation
    John P Forman; Fiscal Year: 2013
    ..units/week of vitamin D supplementation to placebo for 8 weeks, or comparing uric acid lowering with either allopurinol 300 mg/day or probenecid 500 mg/day (both with a dose titration at 4 weeks to 600 mg/day or 1000 mg/day, ..
  7. XOR Regulation of Endothelial Cell Apoptosis in the Model of VALI
    BO SOO KIM; Fiscal Year: 2010
    ..We have shown that pharmacologic inhibition of XOR with allopurinol abrogates HVT- induced increase in vascular leakage indicating that signaling through this pathway is necessary ..
  8. Uric Acid as a Mediator of Endothelial Dysfunction in Patients with CKD
    Diana I Jalal; Fiscal Year: 2013
    ..patients with stage III CKD and serum uric acid levels acid >7mg/dL will be randomized to either placebo or allopurinol for 3 months. The specific aims of the proposal include: 1...
  9. Patient Centered Outcomes Research in Rheumatology
    DANIEL HAL SOLOMON; Fiscal Year: 2013
    ..Strong epidemiologic data link hyperuricemia with CVD, but there have been no large studies examining whether treatments such as allopurinol, febuxostat, probenecid, or pegloticase may play a role in reducing CVD.
  10. New Plasmodium Strategies to Modulate Inflammation
    Ana Rodriguez; Fiscal Year: 2009
    ..However, we observed that hypoxanthine was only active when it is degraded into uric. Addition of allopurinol, an inhibitor of hypoxanthine degradation, inhibited the production of cytokines induced by P...
  11. Investigation of the role of DAMP molecules in the pathogenesis of Liver Injury
    BRITTANY V MURPHY; Fiscal Year: 2012
    ..stimulation of KC will be determined using neutralizing anti-HMGB-1 and anti-HSP-70 antibodies, as well as allopurinol and uricase...
  12. Natural Substance Derivative DHNB is A Novel Xanthine Oxidase Inhibitor
    Changyi Chen; Fiscal Year: 2013
    ..Current drugs targeting XO include Allopurinol and Febuxostat, which have many side effects...
  13. Centers of Research Translation (CoRT)
    Kenneth G Saag; Fiscal Year: 2013
    ..inflammation (CRP), vascular disease (endothelial function), and blood pressure changes associated with the ULT allopurinol (Project 2);examine factors associated with suboptimal gout care and factors influencing effective and safer ..
  14. Data Coordinating Center for Pilot Studies of Candidate Therapies for CKD
    Jennifer J Gassman; Fiscal Year: 2013
    ..selected and finalized by the Steering Committee, the DCC would coordinate a 36-month pilot clinical trial of allopurinol vs placebo, with 12 months of randomization and a minimum of 24 months follow up per patient...
  15. PATHOPHYSIOLOGY OF ISCHEMIA-REPERFUSION LUNG INJURY
    AUBREY TAYLOR; Fiscal Year: 1992
    ..ischemia- reperfusion versus hypoxia-reoxygenation, determination of the effect of blocking xanthine oxidase (allopurinol, or a tungsten- enriched diet) and removing neutrophils from the perfusate...
  16. Xanthine oxidase inhibitor for congestive heart failure
    Alex Nivorozhkin; Fiscal Year: 2002
    ..and many of the classic features of CHF, XO activity is 4-fold increased and the weak XO inhibitor allopurinol increases dP/dt(max), preload-recruitable stroke work, and ventricular elastance...
  17. OXIDATIVE STRESS IN SEIZURE INDUCED NEURONAL INJURY
    WOLF DIETRICH DETTBARN; Fiscal Year: 1999
    ..and injury such as the endogenous vitamin E and glutathione, inhibitors of xanthine oxidase such as allopurinol, N-Methyl-D-Aspartate (NMDA) receptor antagonists, and inhibitors of lipid peoxidation such as lazaroids, and (..
  18. Novel xanthine oxidase inhibitor for hemorrhagic shock
    Pal Pacher; Fiscal Year: 2001
    ..we have invented a novel ultrapotent XO inhibitor (entitled "AHPP-IV") that is three logs more potent than allopurinol and oxypurinol...
  19. Novel xanthine oxidase inhibitor for arthritis
    Zsuzsanna Zsengeller; Fiscal Year: 2004
    ..XO to the pathogenesis of arthritis is demonstrated in numerous rodent models of autoimmune arthritis in which allopurinol, a prototypic XO inhibitor, profoundly reduces joint injury...
  20. Treatment of Calcium Nephrolithiasis Sodium Thiosulfate
    John Asplin; Fiscal Year: 2006
    ..proven effective in prospective placebo controlled trials, thiazide diuretics, potassium citrate salts, and allopurinol. Sodium thiosulfate is a generic drug that is considered to be safe for use in humans...
  21. PRESERVATION OF THE ISCHEMIC/REPERFUSED MYOCARDIUM
    Michael Hess; Fiscal Year: 1990
    ..or inhibitors of free radical generation (indomethacin and ibuprofen for the cyclooxygenase system and allopurinol for the xanthine oxidase system) will protect myocardial hemodynamic, mechanical, sarcolemmal and sarcoplasmic ..
  22. MOLECULAR GENETIC STUDIES OF UREA CYCLE DISORDERS
    JANICE FINKELSTEIN; Fiscal Year: 1990
    ..DNA haplotype analysis will then be used to assess the accuracy of allopurinol-induced orotidinuria in the detection of OTS deficiency-carrier females...
  23. ATP DEGRADATION SYSTEM IN ACUTE TISSUE INJURY
    Cyril Grum; Fiscal Year: 1991
    ..I will determine the degree of ATP degradation, the amount of H202 production and the effect of allopurinol administration of these mechanisms...
  24. HYPOTHERMIC CARDIAC ARREST AND PERINATAL BRAIN DAMAGE
    ROBERT VANNUCCI; Fiscal Year: 1992
    ..thiopental sodium), calcium channel blockers (flunarazne and/or nimodipin) and the xanthine oxidase inhibitor allopurinol. It is anticipated that these investigations will provide important insight into the physicochemical mechanism(..
  25. ETIOLOGY OF BLOOD DYSCRASIAS--ANALYSIS OF THE IAAAS DATA
    David Kaufman; Fiscal Year: 1990
    ..categories such as psychotropics, antihistamines, and cardiovascular drugs, and individual drugs such as allopurinol. Factors other than drugs will also be evaluated, including exposure to radiation and chemicals such as benzene ..
  26. Xanthine Oxidase, Myocardial Genomics and Heart Failure
    Thomas Cappola; Fiscal Year: 2007
    ..In Aim 3, the applicant will test the hypothesis that XO inhibition with allopurinol attenuates the expression of hypertrophy genes in serial endomyocardial biopsies, and prevents an increase in ..
  27. INBORN ERRORS OF A PURINE SALVAGE PATHWAY
    Jay Tischfield; Fiscal Year: 2000
    ..The therapeutic effects of allopurinol, hypoxanthine, and diet modifications will be evaluated...
  28. HEMODYNAMIC PROBLEMS IN ARRHYTHMIA SURGERY
    HENRY SPOTNITZ; Fiscal Year: 1990
    ..The effects of EP testing on LV function will be studied and interventions, including hypothermia, allopurinol and nitrates, will be investigated in an effort to minimize injury...
  29. ALLOPURINOL MODIFICATION OF 5-FLUOROURACIL TOXICITY
    PAULINE SCHWARTZ; Fiscal Year: 1980
    ..uncovered a unique approach for increasing the therapeutic index of 5-fluorouracil (5-FU) by combining it with allopurinol (HPP)...
  30. PURINE ANALOG METABOLISM IN AFRICAN TRYPANOSOMES
    RANDOLPH BERENS; Fiscal Year: 1990
    ..Other analogs, such as allopurinol riboside and thiopurinol riboside, are much less effective against the former parasites when their ..
  31. HYPERTHERMIC LIVER INJURY AND LIPID PEROXIDATION
    JOSEPH SKIBBA; Fiscal Year: 1991
    Hypothesis: Inhibition of xanthine oxidase by allopurinol, and chelation of available iron by desferrioxamine can substantially ameliorate the oxidative stress incurred during hyperthermic liver perfusion...
  32. IDENTIFYING TOR'S MODE OF ACTION
    Siegfried Detke; Fiscal Year: 2002
    ..Similar problems occur with the drugs used for the other Trypanosomes. The purine analogs allopurinol and allopurinol riboside, on the other hand, are toxic to these organisms but relatively benign to humans and ..
  33. Vascular responses in transgenic sickle cell mice
    Beatrice Gee; Fiscal Year: 2007
    ..To examine the effects of xanthine oxidase, hydrogen peroxide, and allopurinol on in vitro sickle erythrocyte interactions with human brain microvascular cells (HBEC), and to characterize ..
  34. HEART ISCHEMIC DAMAGE: MODULATING OXYGEN METABOLITES
    MARSHAL SHLAFER; Fiscal Year: 1992
    ..AIM 3 is to assess biochemical mechanisms by which allopurinol acts in hearts that are allegedly devoid of its target enzyme, xanthine oxidase, either to produce beneficial ..
  35. LENS PROTEINS & FLUORESCENCE: IN VIVO AND IN VITRO STUDY
    SIDNEY LERMAN; Fiscal Year: 1990
    ..continuing our investigations on (UV) photosensitized damage as exemplified by our work on the Psoralens and Allopurinol. The biophysical (fluorescence) in vivo approach is being applied to such patients, and our in vitro ..
  36. REGULATION OF PURINE NUCLEOTIDE SYNTHESIS IN HUMANS
    Michael Becker; Fiscal Year: 2001
    ....
  37. First Int'l Symposium on Childhood and Adolescent NHL
    Mitchell Cairo; Fiscal Year: 2003
    ..abstract_text> ..
  38. Nonablative AlloSCT in Refractory Autoimmune Disease
    Mitchell Cairo; Fiscal Year: 2003
    ....
  39. Polyamine Metabolism in Leishmania
    Buddy Ullman; Fiscal Year: 2008
    ..donovani. We propose, therefore, to ascertain whether the disparity in the abilities of ?lmarg L. mexicana and ?ldodc L. donovani to infect mice can be ascribed to species or gene differences. ..
  40. Cyclooxygenase Pathway and Diabetic Neuropathy
    Rodica Pop Busui; Fiscal Year: 2005
    ..abstract_text> ..
  41. Hypertonic Modulation of Inflammation following Injury
    Eileen M Bulger; Fiscal Year: 2010
    ..The results of these studies will provide valuable information to determine the ultimate therapeutic use of the resuscitation strategy. ..
  42. MECHANISM-BASED DRUG SELECTION AND DESIGN: NUCLEOTIDE SA
    Buddy Ullman; Fiscal Year: 2003
    ..Concurrent experiments will determine how NTPase functions in AK HGXPRT-, and AT parasites, identify the protein(s) which regulate NTPase enzymatic activity, and evaluate the impact of abrogating NTPase expression on parasite viability. ..
  43. Diabetes and Drug-Associated Hyperkalemia: Effect of Laboratory Monitoring
    Marsha Raebel; Fiscal Year: 2008
    ..The findings will also assist in developing a framework for future studies to evaluate the effects and costs of medication-laboratory monitoring among patients with diabetes. [unreadable] [unreadable] [unreadable] [unreadable]..
  44. University of Michigan Comprehensive Cancer Center CCOP*
    Dean Brenner; Fiscal Year: 2007
    ..Affiliations with Minority Based CCOPs have been forged to enhance recruitment of underserved minorities. ..
  45. Cancer Prevention: Translation of Molecular Revolution
    Dean Brenner; Fiscal Year: 2004
    ..abstract_text> ..
  46. PTHRP 1 to 173 IN CHONDROCYTES
    Robert Terkeltaub; Fiscal Year: 2005
    ..Completion of these studies will indicate not only how PTHrP 1-173 can modulate OA, but also how functional properties of the PTHrP 1-173 C-terminal 140-173 domain can be harnessed to promote cartilage repair. ..
  47. Preclinical Development of PEG-TNF
    JOHN BOMALASKI; Fiscal Year: 2005
    ..The data from these studies will provide the final information enabling the filing of an IND with the FDA to support human Phase I clinical testing. ..
  48. The Effect of Hypertonic Resuscitation for Blunt Trauma
    Eileen Bulger; Fiscal Year: 2005
    ..abstract_text> ..
  49. Primary Prevention of Hypertension in Obese Adolescents
    Daniel Feig; Fiscal Year: 2006
    ..In the R21 feasibility phase, subjects age 11-18 with uric acid > 5.0mg/dl will be randomized to placebo, allopurinol or probenecid, for 2 months and screened for improvements in endothelial function (total nitrates, SVR, ..
  50. Preclinical Development of Uricase-PEG 20
    JOHN BOMALASKI; Fiscal Year: 2002
    ..uricase-PEG 20 is formulated with polyethylene glycol (PEG), a technology known to reduce the antigenicity of heterologous proteins. ..
  51. Osteoporosis in Women with Rheumatoid Arthritis
    Daniel Solomon; Fiscal Year: 2006
    ..This epidemiologic data will inform future trials of osteoporosis treatments among patients with RA. As well, the study cohort will comprise one of the largest RA registries with an explicit plan to examine osteoporosis. ..
  52. R13 travel grant for Polyamine/parasite conference in Portland, OR
    Buddy Ullman; Fiscal Year: 2006
    ..abstract_text> ..
  53. GENETIC ANALYSIS OF PURINE METABOLISM IN LEISHMANIA DONO
    Buddy Ullman; Fiscal Year: 2007
    ..if not essential, nutritional function[unreadable] for the parasite, and that initiates the metabolism of allopurinol, a drug[unreadable] that exhibits therapeutic efficacy in both leishmaniasis and Chagas[unreadable] disease...
  54. Role of SLc11a1 Gen in Warm Ischemia-Reperfusion Injury
    Samuel Wyllie; Fiscal Year: 2006
    ..These studies will identify molecular mechanisms by which Slc11a1 modulates liver I/R injury, and will provide a novel target for therapeutic intervention in I/R-mediated organ injury. ..
  55. Uric Acid in Childhood Hypertension
    Daniel Feig; Fiscal Year: 2007
    ..We propose to test whether the use of the xanthine oxidase inhibitor allopurinol, a uric acid lowering drug, will (1) ameliorate primary hypertension in children and (2) control hypertension ..
  56. Sixth Annual Meeting of the Internatioanl Society for the Prevention of Tobacco I
    Parimal Chowdhury; Fiscal Year: 2007
    ..Thus, this meeting will be a resource to decrease the huge sociological and economic burden the world faces regarding addiction to tobacco. [unreadable] [unreadable] [unreadable]..
  57. ANK and Joint Ankylosis in Spondylitis
    Robert Terkeltaub; Fiscal Year: 2008
    ..These studies will identify novel targets for enthesopathic bone fusion in spondyloarthritis. ..
  58. Translational Research in Cancer Prevention
    Dean Brenner; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  59. Nitric Oxide/cGMP/Endotoxin-Induced Myocardial Dysfunct
    Fumito Ichinose; Fiscal Year: 2008
    ....
  60. Pain Medication Use & Risk Factors for Opioid Dependence
    Daniel Solomon; Fiscal Year: 2004
    ..Our goal is to use the results of the proposed research to inform a future intervention to improve opioid prescribing within this large pharmacy benefits program. ..