adenine

Summary

Summary: A purine base and a fundamental unit of ADENINE NUCLEOTIDES.

Top Publications

  1. pmc Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing
    Gang Fang
    Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, USA
    Nat Biotechnol 30:1232-9. 2012
  2. pmc Association of tenofovir exposure with kidney disease risk in HIV infection
    Rebecca Scherzer
    Department of Medicine, San Francisco Veterans Affairs Medical Center, California, USA
    AIDS 26:867-75. 2012
  3. ncbi Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral-naive patients: a 3-year randomized trial
    Joel E Gallant
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    JAMA 292:191-201. 2004
  4. pmc Roles of DNA adenine methylation in host-pathogen interactions: mismatch repair, transcriptional regulation, and more
    Martin G Marinus
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts, Worcester, USA
    FEMS Microbiol Rev 33:488-503. 2009
  5. ncbi Tenofovir-associated kidney toxicity in HIV-infected patients: a review of the evidence
    Andrew M Hall
    UCL Centre for Nephrology, Royal Free Campus, University College London, London, UK
    Am J Kidney Dis 57:773-80. 2011
  6. ncbi Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz for HIV
    Joel E Gallant
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    N Engl J Med 354:251-60. 2006
  7. ncbi Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells
    T Kanzawa
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Cell Death Differ 11:448-57. 2004
  8. ncbi Systematic review and meta-analysis: renal safety of tenofovir disoproxil fumarate in HIV-infected patients
    Ryan D Cooper
    Department of Medicine, University of Alberta, Edmonton, Canada
    Clin Infect Dis 51:496-505. 2010
  9. pmc N6-methyl-adenine: an epigenetic signal for DNA-protein interactions
    Didier Wion
    INSERM U318, CHU Michallon, Universite Joseph Fourier, 38043 Grenoble, France
    Nat Rev Microbiol 4:183-92. 2006
  10. ncbi Simplification of antiretroviral therapy with tenofovir-emtricitabine or abacavir-Lamivudine: a randomized, 96-week trial
    Allison Martin
    National Centre in HIV Epidemiology and Clinical Research UNSW, 5St Vincent s Centre for Applied Medical Research, Sydney, Australia
    Clin Infect Dis 49:1591-601. 2009

Detail Information

Publications364 found, 100 shown here

  1. pmc Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing
    Gang Fang
    Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, USA
    Nat Biotechnol 30:1232-9. 2012
    ....
  2. pmc Association of tenofovir exposure with kidney disease risk in HIV infection
    Rebecca Scherzer
    Department of Medicine, San Francisco Veterans Affairs Medical Center, California, USA
    AIDS 26:867-75. 2012
    ..Despite widespread HAART use, HIV disease remains associated with increased risk of kidney disease. Whether tenofovir use is associated with higher risk of kidney disease is controversial...
  3. ncbi Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral-naive patients: a 3-year randomized trial
    Joel E Gallant
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    JAMA 292:191-201. 2004
    ..Tenofovir disoproxil fumarate (DF) is a once-daily nucleotide analogue reverse transcriptase inhibitor...
  4. pmc Roles of DNA adenine methylation in host-pathogen interactions: mismatch repair, transcriptional regulation, and more
    Martin G Marinus
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts, Worcester, USA
    FEMS Microbiol Rev 33:488-503. 2009
    The DNA adenine methyltransferase (Dam methylase) of Gammaproteobacteria and the cell cycle-regulated methyltransferase (CcrM) methylase of Alphaproteobacteria catalyze an identical reaction (methylation of adenosine moieties using S-..
  5. ncbi Tenofovir-associated kidney toxicity in HIV-infected patients: a review of the evidence
    Andrew M Hall
    UCL Centre for Nephrology, Royal Free Campus, University College London, London, UK
    Am J Kidney Dis 57:773-80. 2011
    ....
  6. ncbi Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz for HIV
    Joel E Gallant
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    N Engl J Med 354:251-60. 2006
    ..Durable suppression of replication of the human immunodeficiency virus (HIV) depends on the use of potent, well-tolerated antiretroviral regimens to which patients can easily adhere...
  7. ncbi Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells
    T Kanzawa
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Cell Death Differ 11:448-57. 2004
    ..Application of an autophagy inhibitor that works after the association of LC3 with autophagosome membrane, such as bafilomycin A1, is expected to enhance the cytotoxicity of TMZ for malignant gliomas...
  8. ncbi Systematic review and meta-analysis: renal safety of tenofovir disoproxil fumarate in HIV-infected patients
    Ryan D Cooper
    Department of Medicine, University of Alberta, Edmonton, Canada
    Clin Infect Dis 51:496-505. 2010
    ..However, an increasing number of case reports suggest that TDF use may be associated with significant nephrotoxicity. Our objective was to determine the renal safety of TDF-containing ART regimens for HIV-infected individuals...
  9. pmc N6-methyl-adenine: an epigenetic signal for DNA-protein interactions
    Didier Wion
    INSERM U318, CHU Michallon, Universite Joseph Fourier, 38043 Grenoble, France
    Nat Rev Microbiol 4:183-92. 2006
    N(6)-methyl-adenine is found in the genomes of bacteria, archaea, protists and fungi. Most bacterial DNA adenine methyltransferases are part of restriction-modification systems...
  10. ncbi Simplification of antiretroviral therapy with tenofovir-emtricitabine or abacavir-Lamivudine: a randomized, 96-week trial
    Allison Martin
    National Centre in HIV Epidemiology and Clinical Research UNSW, 5St Vincent s Centre for Applied Medical Research, Sydney, Australia
    Clin Infect Dis 49:1591-601. 2009
    ..Which fixed-dose-combination tablet is more effective and safe is uncertain...
  11. pmc Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice
    Paul W Denton
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS Med 5:e16. 2008
    ..Given the importance of this route of transmission, we investigated the susceptibility of humanized mice to intravaginal HIV-1 infection...
  12. pmc Direct observation of cotranscriptional folding in an adenine riboswitch
    Kirsten L Frieda
    Biophysics Program, Stanford University, Stanford, CA 94305, USA
    Science 338:397-400. 2012
    ..follow the cotranscriptional folding of a nascent RNA and used it to monitor individual transcripts of the pbuE adenine riboswitch, visualizing distinct folding transitions...
  13. ncbi AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli
    Pål Ø Falnes
    Centre for Molecular Biology and Neuroscience, and Institute of Medical Microbiology, University of Oslo, National Hospital, 0027 Oslo, Norway
    Nature 419:178-82. 2002
    ..This mechanism represents a new pathway for DNA repair and the third type of DNA damage reversal mechanism so far discovered...
  14. ncbi Increased risk of abnormal proximal renal tubular function with HIV infection and antiretroviral therapy
    Frédéric Antoine Dauchy
    Services de Maladies Infectieuses et Tropicales and COREVIH, Hopital Pellegrin, CHU de Bordeaux, Université Bordeaux Segalen, Bordeaux, France
    Kidney Int 80:302-9. 2011
    ..22) or had been discontinued (OR 11.49). Thus, cumulative exposure to TDF and/or atazanavir was associated with an increased risk of PRTD, with concern about its reversibility in patients with HIV...
  15. pmc Renal safety of a tenofovir-containing first line regimen: experience from an antiretroviral cohort in rural Lesotho
    Helen Bygrave
    Medecins Sans Frontieres, Morija, Lesotho
    PLoS ONE 6:e17609. 2011
    ..We report prevalence of abnormal renal function at baseline and factors associated with abnormal renal function from a community cohort in Lesotho...
  16. pmc In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicide
    Lisa C Rohan
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e9310. 2010
    ..To validate our findings with on-going clinical trial results, we evaluated topical tenofovir gel for safety and efficacy. We also modeled systemic application of tenofovir for efficacy...
  17. ncbi Long-term efficacy of tenofovir monotherapy for hepatitis B virus-monoinfected patients after failure of nucleoside/nucleotide analogues
    Florian van Bömmel
    Medizinische Klinik m S Hepatologie und Gastroenterologie Charité, Campus Virchow Klinikum, Universitatsmedizin Berlin, Germany
    Hepatology 51:73-80. 2010
    ..Loss of HBeAg occurred in 24% of patients and HBsAg loss occurred in 3%. No significant adverse events were noticed during TDF monotherapy...
  18. ncbi Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B
    Patrick Marcellin
    Service d Hepatologie, INSERM Unité 481, and Centre de Recherches Claude Bernard sur les Hépatites Virales, Hopital Beaujon, Clichy, France
    N Engl J Med 348:808-16. 2003
    ..In preclinical and phase 2 studies, adefovir dipivoxil demonstrated potent activity against hepatitis B virus (HBV), including lamivudine-resistant strains...
  19. ncbi Estimated glomerular filtration rate, chronic kidney disease and antiretroviral drug use in HIV-positive patients
    Amanda Mocroft
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, Division of Population Health, University College London Medical School, Royal Free Campus, London, UK
    AIDS 24:1667-78. 2010
    ..Chronic kidney disease (CKD) in HIV-positive persons might be caused by both HIV and traditional or non-HIV-related factors. Our objective was to investigate long-term exposure to specific antiretroviral drugs and CKD...
  20. pmc Pharmacological considerations for tenofovir and emtricitabine to prevent HIV infection
    Peter L Anderson
    Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO, USA
    J Antimicrob Chemother 66:240-50. 2011
    ..The current state of knowledge in these areas is summarized and the future utility of intracellular pharmacokinetics/pharmacodynamics for the PrEP field is discussed...
  21. pmc Complete protection from repeated vaginal simian-human immunodeficiency virus exposures in macaques by a topical gel containing tenofovir alone or with emtricitabine
    Urvi M Parikh
    Laboratory Branch, Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA
    J Virol 83:10358-65. 2009
    ..Thus, single drugs with durable antiviral activity can provide highly effective topical prophylaxis and overcome the need for noncoital use or for drug combinations which are more complex and costly to formulate and approve...
  22. ncbi Randomized comparison of renal effects, efficacy, and safety with once-daily abacavir/lamivudine versus tenofovir/emtricitabine, administered with efavirenz, in antiretroviral-naive, HIV-1-infected adults: 48-week results from the ASSERT study
    Frank A Post
    King s College London, London, United Kingdom
    J Acquir Immune Defic Syndr 55:49-57. 2010
    ..Abacavir/lamivudine and tenofovir/emtricitabine fixed-dose combinations are commonly used first-line antiretroviral therapies, yet few studies have comprehensively compared their safety profiles...
  23. pmc Bone mineral density and fractures in antiretroviral-naive persons randomized to receive abacavir-lamivudine or tenofovir disoproxil fumarate-emtricitabine along with efavirenz or atazanavir-ritonavir: Aids Clinical Trials Group A5224s, a substudy of ACTG
    Grace A McComsey
    Departments of Pediatrics and Medicine, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, OH 44106, USA
    J Infect Dis 203:1791-801. 2011
    ..Long-term effects of abacavir (ABC)-lamivudine (3TC), compared with tenofovir (TDF)-emtricitabine (FTC) with efavirenz (EFV) or atazanavir plus ritonavir (ATV/r), on bone mineral density (BMD) have not been analyzed...
  24. ncbi Comparison of changes in bone density and turnover with abacavir-lamivudine versus tenofovir-emtricitabine in HIV-infected adults: 48-week results from the ASSERT study
    Hans Jurgen Stellbrink
    Infektions Medizinisches Centrum Hamburg Study Center, Hamburg, Germany
    Clin Infect Dis 51:963-72. 2010
    ..Abacavir-lamivudine and tenofovir DF-emtricitabine fixed-dose combinations are commonly used as first-line antiretroviral therapies. However, few studies have comprehensively compared their relative safety profiles...
  25. pmc N6-methyladenine: the other methylated base of DNA
    David Ratel
    INSERM U318, CHU Michallon, Grenoble, France
    Bioessays 28:309-15. 2006
    ..Interestingly, even if adenine methylation is usually considered a bacterial DNA feature, the presence of m6A has been found in protist and ..
  26. ncbi A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation
    D B Munafó
    Laboratorio de Biología Celular y Molecular Instituto de Histología y Embriología, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo CONICET, Mendoza, 5500, Argentina
    J Cell Sci 114:3619-29. 2001
    ..Furthermore, these MDC-vacuoles were labeled with LC3, one of the mammalian homologues of the yeast protein Apg8/Aut7 that plays an important role in autophagosome formation...
  27. pmc Meta-analysis: adefovir dipivoxil in combination with lamivudine in patients with lamivudine-resistant hepatitis B virus
    En Qiang Chen
    Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China
    Virol J 6:163. 2009
    ..The aim of study was to evaluate the efficacy of rescue therapy with ADV plus LAM compared to ADV monotherapy in LAM-resistant CHB patients...
  28. ncbi Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 years
    Stephanos J Hadziyannis
    Department of Medicine and Hepatology, Henry Dunant Hospital, Athens, Greece
    Gastroenterology 131:1743-51. 2006
    ..We investigated the efficacy, safety, and resistance profile of adefovir dipivoxil treatment for up to 240 weeks...
  29. ncbi Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta
    R E Johnson
    Sealy Center for Molecular Science, University of Texas Medical Branch at Galveston, 6 104 Medical Research Building, 11th and Mechanic Streets, Galveston, TX 77555 1061, USA
    Science 283:1001-4. 1999
    ..When incubated in vitro with all four nucleotides, Rad30 incorporates two adenines opposite the thymine-thymine dimer. Rad30 is the seventh eukaryotic DNA polymerase to be described and hence is named DNA polymerase eta...
  30. ncbi Early hepatitis B virus DNA reduction in hepatitis B e antigen-positive patients with chronic hepatitis B: A randomized international study of entecavir versus adefovir
    Nancy Leung
    Alice Ho Miu Ling Nethersole Hospital, Taipo, Hong Kong SAR, China
    Hepatology 49:72-9. 2009
    ..At week 48, one (3%) ETV-treated versus 15 (47%) ADV-treated patients had HBV DNA of 10(5) copies/mL or more. Both antivirals were well tolerated...
  31. pmc Comparative study between transcriptionally- and translationally-acting adenine riboswitches reveals key differences in riboswitch regulatory mechanisms
    Jean François Lemay
    Groupe ARN RNA Group, Departement de Biologie, Faculte des Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    PLoS Genet 7:e1001278. 2011
    ..Although they both bind adenine, the adenine riboswitches of Bacillus subtilis and Vibrio vulnificus differ by controlling transcription and ..
  32. ncbi Adding-on versus switching-to adefovir therapy in lamivudine-resistant HBeAg-negative chronic hepatitis B
    Irene Rapti
    Department of Medicine and Liver Unit, Henry Dunant Hospital, Athens, Greece
    Hepatology 45:307-13. 2007
    ....
  33. ncbi Tenofovir disoproxil fumarate, emtricitabine, and efavirenz compared with zidovudine/lamivudine and efavirenz in treatment-naive patients: 144-week analysis
    Jose R Arribas
    Internal Medicine Service, Hospital de La Paz, Madrid, Spain
    J Acquir Immune Defic Syndr 47:74-8. 2008
    ..As antiretroviral regimens for the treatment of HIV infection improve, trials providing data on long-term follow-up are increasingly important...
  34. ncbi Comparison of adefovir and tenofovir in the treatment of lamivudine-resistant hepatitis B virus infection
    Florian van Bömmel
    Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Charite, Universitatsmedizin Berlin, Campus Virchow, Berlin, Germany
    Hepatology 40:1421-5. 2004
    ..In conclusion, tenofovir may become an effective alternative for the treatment of patients with lamivudine-resistant HBV infection...
  35. ncbi Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways
    Ya Dan Wen
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    Autophagy 4:762-9. 2008
    ..death, rats were pretreated with a single intracerebral ventricle injection of the autophagy inhibitors 3-methyl-adenine (3-MA) and bafliomycin A1 (BFA) or the cathepsin B inhibitor Z-FA-fmk after pMCAO...
  36. ncbi Tenofovir nephrotoxicity: acute tubular necrosis with distinctive clinical, pathological, and mitochondrial abnormalities
    Leal C Herlitz
    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Kidney Int 78:1171-7. 2010
    ..Our study shows that tenofovir nephrotoxicity is a largely reversible form of toxic acute tubular necrosis targeting proximal tubules and manifesting distinctive light microscopic and ultrastructural features of mitochondrial injury...
  37. ncbi Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury
    Silvia Carloni
    Institute of Pharmacology and Pharmacognosy, University of Urbino Carlo Bo, Urbino, Italy
    Neurobiol Dis 32:329-39. 2008
    ....
  38. ncbi A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles
    S Paglin
    Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 61:439-44. 2001
    ....
  39. ncbi Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase
    Peter Angus
    Austin Hospital, Studley Road, Heidelberg, Victoria 3084, Australia
    Gastroenterology 125:292-7. 2003
    ..The aim of this study was to characterize adefovir resistance in a patient who developed clinical and virologic evidence of breakthrough during a 96-week course of treatment...
  40. pmc Single-molecule force spectroscopy of the add adenine riboswitch relates folding to regulatory mechanism
    Krishna Neupane
    Department of Physics, University of Alberta, Edmonton, Alberta, Canada
    Nucleic Acids Res 39:7677-87. 2011
    ..By unfolding and refolding single add adenine riboswitch molecules in an optical trap, an integrated picture of the folding was developed and related to the ..
  41. pmc Abacavir-lamivudine versus tenofovir-emtricitabine for initial HIV-1 therapy
    Paul E Sax
    Division of Infectious Diseases and the Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 361:2230-40. 2009
    ....
  42. pmc Impact of small body weight on tenofovir-associated renal dysfunction in HIV-infected patients: a retrospective cohort study of Japanese patients
    Takeshi Nishijima
    National Center for Global Health and Medicine, Tokyo, Japan
    PLoS ONE 6:e22661. 2011
    ..Limited information is available on this side effect in patients with small body weight, although the use of tenofovir will spread rapidly in Asia and Africa, where patients are likely to be of smaller body weight...
  43. ncbi Entecavir plus tenofovir combination as rescue therapy in pre-treated chronic hepatitis B patients: an international multicenter cohort study
    Jorg Petersen
    Liver Unit, Ifi Institute for Interdisciplinary Medicine, Asklepios Klinik St Georg Hamburg, Germany
    J Hepatol 56:520-6. 2012
    ..Aim of this study was to investigate the efficacy and safety of entecavir plus tenofovir combination in 57 CHB partial responders or multidrug resistant patients...
  44. pmc Durable protection from vaginal simian-human immunodeficiency virus infection in macaques by tenofovir gel and its relationship to drug levels in tissue
    Charles Dobard
    Laboratory Branch and Quantitative Sciences and Data Management Branch, Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 86:718-25. 2012
    ..The identification of protective TFV-DP concentrations in vaginal lymphocytes may facilitate the evaluation of improved delivery methods of topical TFV and inform clinical studies...
  45. ncbi Randomized, double-blind, placebo-matched, multicenter trial of abacavir/lamivudine or tenofovir/emtricitabine with lopinavir/ritonavir for initial HIV treatment
    Kimberly Y Smith
    Rush University Medical Center, Chicago, Illinois 60612, USA
    AIDS 23:1547-56. 2009
    ..This is the first completed, randomized clinical trial to directly compare the efficacy, safety, and tolerability of these agents, each in combination with lopinavir/ritonavir in antiretroviral-naive patients...
  46. pmc Renal function declines more in tenofovir- than abacavir-based antiretroviral therapy in low-body weight treatment-naïve patients with HIV infection
    Takeshi Nishijima
    AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan
    PLoS ONE 7:e29977. 2012
    ..To compare the rate of decline of renal function in tenofovir- and abacavir-based antiretroviral therapy (ART) in low-body weight treatment-naïve patients with HIV infection...
  47. ncbi Reference MP2/CBS and CCSD(T) quantum-chemical calculations on stacked adenine dimers. Comparison with DFT-D, MP2.5, SCS(MI)-MP2, M06-2X, CBS(SCS-D) and force field descriptions
    Claudio A Morgado
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic
    Phys Chem Chem Phys 12:3522-34. 2010
    We have performed reference quantum-chemical calculations for about 130 structures of adenine dimers in stacked conformations, with special attention given to dimers that are either vertically compressed (parallel structures) or contain ..
  48. ncbi Greater tenofovir-associated renal function decline with protease inhibitor-based versus nonnucleoside reverse-transcriptase inhibitor-based therapy
    Miguel Goicoechea
    Antiviral Research Center, University of California, San Diego, 150 W Washington St, Ste 100, San Diego, CA 92103, USA
    J Infect Dis 197:102-8. 2008
    ....
  49. ncbi Pharmacokinetics and safety of tenofovir disoproxil fumarate on coadministration with lopinavir/ritonavir
    Brian P Kearney
    Gilead Sciences, Inc, Foster City, CA, USA
    J Acquir Immune Defic Syndr 43:278-83. 2006
    ..Lopinavir/ritonavir (LPV/r) and tenofovir disoproxil fumarate (TDF) are frequently used antiretrovirals. A pharmacokinetic study in healthy volunteers was conducted to assess the potential for a drug interaction between these agents...
  50. pmc Resistance to adefovir dipivoxil in lamivudine resistant chronic hepatitis B patients treated with adefovir dipivoxil
    J E Yeon
    Korea University Medical College Guro Hospital, Department of Internal Medicine, Division of Gastroenterology and Hepatology, Guro gu Guro dong gil 97, Seoul, Korea
    Gut 55:1488-95. 2006
    ..The cumulative incidence of ADV resistant mutations in the nucleoside/-tide treatment naive chronic hepatitis B patient (CHB) at weeks 48, 96, and 144 was 0, 0.8-3%, and approximately 5.9%, respectively...
  51. ncbi Tenofovir is effective alone or with emtricitabine in adefovir-treated patients with chronic-hepatitis B virus infection
    Thomas Berg
    Universitätsklinik Leipzig, Leipzig, Germany
    Gastroenterology 139:1207-17. 2010
    ..We evaluated a combination of fixed-dose emtricitabine (FTC) and tenofovir disoproxil fumarate (TDF) from the start (early combination) versus TDF as monotherapy...
  52. pmc Atomic substitution reveals the structural basis for substrate adenine recognition and removal by adenine DNA glycosylase
    Seongmin Lee
    Departments of Stem Cell and Regenerative Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 106:18497-502. 2009
    b>Adenine DNA glycosylase catalyzes the glycolytic removal of adenine from the promutagenic A.oxoG base pair in DNA...
  53. pmc Replication through an abasic DNA lesion: structural basis for adenine selectivity
    Samra Obeid
    Konstanz Research School Chemical Biology, University of Konstanz, Konstanz, Germany
    EMBO J 29:1738-47. 2010
    ..Although these lesions are devoid of the genetic information, adenine is most efficiently inserted when abasic sites are bypassed by DNA polymerases, a phenomenon termed A-rule...
  54. ncbi Prospective study of renal function in HIV-infected pediatric patients receiving tenofovir-containing HAART regimens
    Pere Soler-Palacín
    Pediatric Infectious Diseases and Immunodeficiencies Unit, Vall d Hebron University Hospital, Spain
    AIDS 25:171-6. 2011
    ..to describe the impact of tenofovir disoproxil fumarate (TDF) use on renal function in HIV-infected pediatric patients...
  55. ncbi Tenofovir-associated acute and chronic kidney disease: a case of multiple drug interactions
    Anthony E Zimmermann
    Massachusetts College of Pharmacy and Health Science, Worcester, Massachusetts, USA
    Clin Infect Dis 42:283-90. 2006
    ..Tenofovir is associated with multiple drug interactions, leading to an increased risk of ARF. Frequent monitoring of renal function is warranted for any patient receiving these combinations...
  56. ncbi Effects of Gum Arabic in rats with adenine-induced chronic renal failure
    Badreldin H Ali
    Department of Pharmacology, Sultan Qaboos University, Al Khod, Sultanate of Oman
    Exp Biol Med (Maywood) 235:373-82. 2010
    ..Here, we used another animal model of human CRF (feeding adenine at a concentration of 0.75%(w/w) for four weeks) to test the effect of GA on CRF...
  57. pmc Antiretroviral therapies in women after single-dose nevirapine exposure
    Shahin Lockman
    Brigham and Women s Hospital, Boston, MA, USA
    N Engl J Med 363:1499-509. 2010
    ..Peripartum administration of single-dose nevirapine reduces mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) but selects for nevirapine-resistant virus...
  58. ncbi Incomplete reversibility of tenofovir-related renal toxicity in HIV-infected men
    Karen Wever
    HIV, Immunology, and Infectious Disease Unit and Centre for Applied Medical Research, St Vincent s Hospital, Sydney, Australia
    J Acquir Immune Defic Syndr 55:78-81. 2010
    ..This nephrotoxicity is said to resolve rapidly, but this assessment is based on short follow-up, very few patients and use of serum creatinine, an insensitive measure of renal function...
  59. pmc hMYH cell cycle-dependent expression, subcellular localization and association with replication foci: evidence suggesting replication-coupled repair of adenine:8-oxoguanine mispairs
    I Boldogh
    Department of Microbiology, Sealy Center for Environmental Health and Medicine, University of Texas Medical Branch, Galveston, TX 77555-1071 USA
    Nucleic Acids Res 29:2802-9. 2001
    The human MutY homolog, hMYH, is an adenine-specific DNA glycosylase that removes adenines or 2-hydroxyadenines mispaired with guanines or 8-oxoguanines...
  60. ncbi Long-term therapy with tenofovir is effective for patients co-infected with human immunodeficiency virus and hepatitis B virus
    Theodora E M S de Vries-Sluijs
    Department of Internal Medicine Infectious Diseases, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Gastroenterology 139:1934-41. 2010
    ..We investigated the long-term efficacy and renal safety of tenofovir disoproxil fumarate (TDF), administered to patients co-infected with human immunodeficiency virus and hepatitis B virus (HBV) as part of an antiretroviral therapy...
  61. pmc DNA adenine methylation is required to replicate both Vibrio cholerae chromosomes once per cell cycle
    Gaëlle Demarre
    Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS Genet 6:e1000939. 2010
    DNA adenine methylation is widely used to control many DNA transactions, including replication. In Escherichia coli, methylation serves to silence newly synthesized (hemimethylated) sister origins...
  62. ncbi Tenofovir disoproxil fumarate rescue therapy following failure of both lamivudine and adefovir dipivoxil in chronic hepatitis B
    S J Patterson
    Liver Transplant Unit, Austin Health, Studley Road, Heidelberg, VIC 3084, Australia
    Gut 60:247-54. 2011
    ....
  63. pmc Activation of anti-hepatitis C virus responses via Toll-like receptor 7
    Jongdae Lee
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0663, USA
    Proc Natl Acad Sci U S A 103:1828-33. 2006
    ..Prolonged exposure of Huh-7 cells to a TLR7 ligand [SM360320 (9-benzyl-8-hydroxy-2-(2-methoxyethoxy)adenine)], alone or in combination with an inosine monophosphate dehydrogenase inhibitor, reduced HCV levels dose ..
  64. pmc Replication cycle-coordinated change of the adenine nucleotide-bound forms of DnaA protein in Escherichia coli
    K Kurokawa
    Department of Molecular Microbiology, Kyushu University Graduate School of Pharmaceutical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    EMBO J 18:6642-52. 1999
    ..Regeneration of ATP-DnaA from ADP-DnaA was also observed. These results indicate that the nucleotide form shifts of DnaA are tightly linked with an epistatic cell cycle event and with the chromosomal replication system...
  65. ncbi Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study
    Sonia Rodriguez-Novoa
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    Clin Infect Dis 48:e108-16. 2009
    ..Although rare, the mechanism by which tenofovir causes renal damage is not well characterized. We have explored the association between kidney tubular dysfunction (KTD) and polymorphisms in genes encoding drug transporters...
  66. ncbi Determining the antiviral activity of tenofovir disoproxil fumarate in treatment-naive chronically HIV-1-infected individuals
    Michael Louie
    Aaron Diamond AIDS Research Center, Rockefeller University, New York, NY 10016, USA
    AIDS 17:1151-6. 2003
    ..To assess the efficacy of tenofovir disoproxil fumarate (TDF) monotherapy by following the initial rate of decline in plasma viral load, which is a measure of the efficacy of therapy in blocking viral replication...
  67. ncbi Rescue therapy for lamivudine-resistant chronic hepatitis B: comparison between entecavir 1.0 mg monotherapy, adefovir monotherapy and adefovir add-on lamivudine combination therapy
    Hong Joo Kim
    Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, Jongro Ku, Seoul, Korea
    J Gastroenterol Hepatol 25:1374-80. 2010
    ..We aimed to compare the cumulative efficacy and resistance of ETV 1.0 mg monotherapy, ADV monotherapy and ADV add-on LAM combination therapy in LAM-refractory patients...
  68. pmc A multi-compartment, single and multiple dose pharmacokinetic study of the vaginal candidate microbicide 1% tenofovir gel
    Jill L Schwartz
    CONRAD, Eastern Virginia Medical School, Arlington, Virginia, United States of America
    PLoS ONE 6:e25974. 2011
    ..Tenofovir (TFV) gel is being evaluated as a microbicide with pericoital and daily regimens. To inhibit viral replication locally, an adequate concentration in the genital tract is critical...
  69. pmc Activation of autophagy in a rat model of retinal ischemia following high intraocular pressure
    Antonio Piras
    Neuroscience Institute of the Cavalieri Ottolenghi Foundation, Orbassano, Torino, Italy
    PLoS ONE 6:e22514. 2011
    ..Treatment also prevented the increase in glial fibrillary acid protein immunoreactivity elicited by I/R. Therefore, targeting autophagy could represent a novel and promising treatment for glaucoma and retinal ischemia...
  70. ncbi Tenofovir and entecavir are the most effective antiviral agents for chronic hepatitis B: a systematic review and Bayesian meta-analyses
    Gloria Woo
    Toronto Health Economics and Technology Assessment Collaborative, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 139:1218-29. 2010
    ..We evaluated the relative efficacies of the first 12 months of CHB treatments...
  71. pmc Relationship between renal dysfunction, nephrotoxicity and death among HIV adults on tenofovir
    Alana Brennan
    Center for Global Health and Development, Boston University, Massachusetts, USA
    AIDS 25:1603-9. 2011
    ..We analyzed the relationship between renal dysfunction at tenofovir initiation, nephrotoxicity and mortality...
  72. pmc PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans
    Dalya R Soond
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom
    Blood 115:2203-13. 2010
    ..There is therefore a strong rationale for p110delta inhibitors to be considered for therapeutic use in T-cell-mediated autoimmune and inflammatory diseases...
  73. pmc Early clinical and programmatic outcomes with tenofovir-based antiretroviral therapy in Zambia
    Benjamin H Chi
    Centre for Infectious Disease Research in Zambia, Lusaka, Zambia
    J Acquir Immune Defic Syndr 54:63-70. 2010
    ..In July 2007, amid some controversy over cost, Zambia was the first African country to introduce tenofovir (TDF) as a component of first-line antiretroviral therapy (ART) on a wide scale...
  74. ncbi Prevalence and factors associated with renal impairment in HIV-infected patients, ANRS C03 Aquitaine Cohort, France
    E K Déti
    Institut National de la Santé et de la Recherche Médicale U897, Bordeaux, F 33076, France
    HIV Med 11:308-17. 2010
    ..The aims of the present study were to estimate the prevalence of renal impairment (RI) among HIV-infected adult patients and to investigate the associated factors...
  75. ncbi Spectrum of chronic kidney disease in HIV-infected patients
    L J Campbell
    Academic Department of HIV GU Medicine, King s College London, London, France
    HIV Med 10:329-36. 2009
    ..The aim of the study was to investigate the prevalence and aetiology of chronic kidney disease (CKD) and trends in estimated glomerular filtration rate (eGFR) in HIV-infected patients...
  76. pmc ARED Organism: expansion of ARED reveals AU-rich element cluster variations between human and mouse
    Anason S Halees
    The Biomolecular Research Program, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia
    Nucleic Acids Res 36:D137-40. 2008
    ..This ultimately will help in inferring the biological consequences of ARE variation in these key animal models as opposed to humans, particularly, in relationships to the role of RNA stability in disease...
  77. ncbi Long-term efficacy and safety of adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B
    Patrick Marcellin
    Hopital Beaujon, Paris, France
    Hepatology 48:750-8. 2008
    ..Adefovir resistance mutations A181V or N236T developed in 13 LTSES patients; the first observation was at study week 195. There were no serious adverse events related to ADV...
  78. ncbi Persistent decline in estimated but not measured glomerular filtration rate on tenofovir may reflect tubular rather than glomerular toxicity
    Saskia M E Vrouenraets
    Department of Global Health, Amsterdam Institute for Global Health and Development, Center for Infection and Immunity, Amsterdam, The Netherlands
    AIDS 25:2149-55. 2011
    ..Tenofovir disoproxil fumarate (TDF) has been associated with proximal renal tubulopathy and reduction in estimated glomerular filtration rate (eGFR), without accounting for the tubular secretion of creatinine...
  79. ncbi Efficacy of adefovir add-on lamivudine rescue therapy compared with switching to entecavir monotherapy in patients with lamivudine-resistant chronic hepatitis B
    Han Jak Ryu
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
    J Med Virol 82:1835-42. 2010
    ..However, ADV add-on therapy had limitations in patients with a higher baseline HBV DNA in LAM rescue therapy...
  80. pmc The autophagic inhibitor 3-methyladenine potently stimulates PKA-dependent lipolysis in adipocytes
    Bradlee L Heckmann
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Scottsdale, AZ, USA
    Br J Pharmacol 168:163-71. 2013
    ..Furthermore, we describe a novel stimulatory effect on a major signalling pathway. Our findings provide valuable information to studies employing 3-MA as a specific inhibitor for PI3K and autophagy...
  81. pmc Renal function with use of a tenofovir-containing initial antiretroviral regimen
    Joel E Gallant
    Department of Medicine, Johns Hopkins University School of Medicine, 1830 E Monument Street, Baltimore, MD 21205, USA
    AIDS 23:1971-5. 2009
    ....
  82. pmc Inhibition of autophagy induction delays neuronal cell loss caused by dysfunctional ESCRT-III in frontotemporal dementia
    Jin A Lee
    Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, California 94158, USA
    J Neurosci 29:8506-11. 2009
    ..These findings show that autophagic stress by excess accumulation of autophagosomes is detrimental to neuronal survival under certain neurodegenerative conditions...
  83. pmc Reformulated tenofovir gel for use as a dual compartment microbicide
    Charlene S Dezzutti
    University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Antimicrob Chemother 67:2139-42. 2012
    ..This study evaluated the pre-clinical safety and efficacy of a reformulated (reduced osmolality) tenofovir gel product...
  84. pmc Activation of autophagy induces retinal ganglion cell death in a chronic hypertensive glaucoma model
    H Y Lopilly Park
    Department of Ophthalmology and Visual Science, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Cell Death Dis 3:e290. 2012
    ..This may show that autophagy is differently regulated in different compartments of the neuron. This present study showed that autophgy is activated in RGCs and has a role in autophagic cell death after chronic IOP elevation...
  85. pmc A review of the virological efficacy of the 4 World Health Organization-recommended tenofovir-containing regimens for initial HIV therapy
    Michele W Tang
    Department of Medicine, Division of Infectious Diseases, Stanford University, California 94305 5107, USA
    Clin Infect Dis 54:862-75. 2012
    ..Further study of TDF/3TC/NVP is required before it is widely deployed for initial ARV therapy...
  86. ncbi The risk of HIV drug resistance following implementation of pre-exposure prophylaxis
    David A M C van de Vijver
    Department of Virology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Curr Opin Infect Dis 23:621-7. 2010
    ..Drug resistance could, therefore, be critical in the use of PrEP. We review the literature regarding risks associated with drug resistance owing to PrEP...
  87. ncbi Osteoporotic fracture risk associated with cumulative exposure to tenofovir and other antiretroviral agents
    Roger Bedimo
    Department of Medicine, VA North Texas Healthcare System, Dallas, Texas, USA
    AIDS 26:825-31. 2012
    ..Whereas tenofovir (TDF) exposure has been associated with decreased bone density, it remains unclear whether it is associated with increased risk of osteoporotic fractures...
  88. ncbi A randomized study of tenofovir disoproxil fumarate in treatment-experienced HIV-1 infected adolescents
    Marinella Della Negra
    Instituto de Infectologia Emilio Ribas, Sao Paulo, Brazil
    Pediatr Infect Dis J 31:469-73. 2012
    ..There are few data on the safety and antiviral activity of tenofovir disoproxil fumarate (TDF) in HIV-1 infected adolescents...
  89. pmc Epidemiological impact of tenofovir gel on the HIV epidemic in South Africa
    Brian G Williams
    South African Centre for Epidemiological Modelling and Analysis SACEMA, Stellenbosch, South Africa
    J Acquir Immune Defic Syndr 58:207-10. 2011
    ..Tenofovir gel, an antiretroviral-based vaginal microbicide, reduced HIV acquisition by 39% in women in a recent randomized controlled clinical trial in South Africa...
  90. pmc High rate of K65R for antiretroviral therapy-naive patients with subtype C HIV infection failing a tenofovir-containing first-line regimen
    Henry Sunpath
    McCord Hospital, Durban, South Africa
    AIDS 26:1679-84. 2012
    ..We sought to determine the rate of the K65R mutation in patients receiving tenofovir (TDF)-based antiretroviral therapy (ART) with subtype C HIV infection...
  91. doi Risk of early virological failure of once-daily tenofovir-emtricitabine plus twice-daily nevirapine in antiretroviral therapy-naive HIV-infected patients
    Giuseppe Lapadula
    Clin Infect Dis 46:1127-9. 2008
  92. ncbi Tenofovir disoproxil fumarate and bone mineral density: a 60-month longitudinal study in a cohort of HIV-infected youths
    Alessandra Vigano
    Pediatric Infectious Diseases Unit, Department of Pediatrics, L Sacco Hospital, University of Milan, Milan, Italy
    Antivir Ther 15:1053-8. 2010
    ..The aim of this study was to assess the safety of a TDF-containing antiretroviral (ARV) regimen on BMD in paediatric patients. We report the results of a longitudinal 60-month follow-up study...
  93. ncbi Implementing a tenofovir-based first-line regimen in rural Lesotho: clinical outcomes and toxicities after two years
    Helen Bygrave
    Medecins Sans Frontieres, Morija, Lesotho
    J Acquir Immune Defic Syndr 56:e75-8. 2011
    ..We report on outcomes and toxicities among patients on these different regimens in a routine treatment cohort in Lesotho...
  94. pmc Regulation of the Salmonella enterica std fimbrial operon by DNA adenine methylation, SeqA, and HdfR
    Marcello Jakomin
    Departamento de Genetica, Facultad de Biologia, Universidad de Sevilla, Apartado 1095, E 41080 Sevilla, Spain
    J Bacteriol 190:7406-13. 2008
    DNA adenine methylase (dam) mutants of Salmonella enterica serovar Typhimurium grown under laboratory conditions express the std fimbrial operon, which is tightly repressed in the wild type...
  95. ncbi Discontinuation of Atripla as first-line therapy in HIV-1 infected individuals
    Andrew Scourfield
    Department of HIV Medicine, Chelsea and Westminster Hospital, Chelsea, UK
    AIDS 26:1399-401. 2012
    ..We aimed to describe the outcomes of individuals commencing Atripla (Gilead Sciences Inc, Foster City, California; Bristol-Myers Squibb Co, Princeton, New Jersey, USA) as a first-line regimen...
  96. ncbi Simplification of antiretroviral therapy to a single-tablet regimen consisting of efavirenz, emtricitabine, and tenofovir disoproxil fumarate versus unmodified antiretroviral therapy in virologically suppressed HIV-1-infected patients
    Edwin DeJesus
    Orlando Immunology Center, Orlando, FL 32803, USA
    J Acquir Immune Defic Syndr 51:163-74. 2009
    ....
  97. ncbi Tenofovir-emtricitabine-efavirenz in HIV-I-infected adults in Senegal: a 96-week pilot trial in treatment-naive patients
    Roland Landman
    Institut de Médecine et d Epidémiologie Appliquée et Hôpital Bichat Claude Bernard, Service des Maladies Infectieuses, Paris, France
    J Int Assoc Physicians AIDS Care (Chic) 8:379-84. 2009
    ..This drug combination can be recommended in limited-resource countries, as did the World Health Organization (WHO) and should be made readily available as a fixed-dose combination...
  98. ncbi Fanconi syndrome and renal failure induced by tenofovir: a first case report
    David Verhelst
    Department of Nephrology, Hopital Tenon AP HP, Paris, France
    Am J Kidney Dis 40:1331-3. 2002
    ....
  99. ncbi The role of HIV and antiretroviral therapy in bone disease
    Felix Gutierrez
    Infectious Diseases Unit, Hospital General Universitario, Elche, Spain
    AIDS Rev 13:109-18. 2011
    ..Given the complex interaction between HIV and drugs in causing low bone mineral density, optimization of antiretroviral therapy and preemptive strategies aimed to prevent bone loss during therapy may be of paramount importance...
  100. ncbi Postischemic treatment of neonatal cerebral ischemia should target autophagy
    Julien Puyal
    Department of Cellular Biology and Morphology, University of Lausanne, Lausanne, Switzerland
    Ann Neurol 66:378-89. 2009
    ..To evaluate the contributions of autophagic, necrotic, and apoptotic cell death mechanisms after neonatal cerebral ischemia and hence define the most appropriate neuroprotective approach for postischemic therapy...
  101. ncbi Efficacy and safety of entecavir versus adefovir in chronic hepatitis B patients with hepatic decompensation: a randomized, open-label study
    Yun Fan Liaw
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Hepatology 54:91-100. 2011
    ..Biochemical and clinical benefits were also demonstrated. Entecavir was well tolerated, and early mortality rates were consistent with rates observed in similar populations treated with lamivudine...

Research Grants68

  1. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  2. Iron in the pathogenesis of Friedreich's ataxia
    ARNULF HANS WERNER KOEPPEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Friedreich's ataxia (FRDA) is due to homozygous transmission of guanine-adenine-adenine (GAA) trinucleotide repeat expansions in parental frataxin (FXN) genes...
  3. Role of Mitochondria in the Regulation of Iron metabolism by Alcohol
    DUYGU DEE DEE HARRISON-FINDIK; Fiscal Year: 2012
    ..We will employ transgenic mouse models deficient in mitochondrial antioxidant enzymes, adenine nucleotide transport, cytochrome c oxidase activity or the dimerization of hypoxia-inducible transcription ..
  4. Regulation of LPS-mediated HMGB1 Release by Poly (ADP-ribose) Polymerase-1
    RAJESH K ANEJA; Fiscal Year: 2013
    ..isoform of the PARPenzyme family and its continued activation leads to depletion of its substrate, nicotinamide adenine dinucleotide (NAD+), with consequent depletion of adenosine-5'-triphosphate (ATP), energy failure and cell ..
  5. Local Calcium Signaling in Pulmonary Arteries
    JAMES SK SHAM; Fiscal Year: 2012
    ..Recent evidence suggests that the novel nicotinic acid adenine dinucleotide phosphate (NAADP)-sensitive lysosomal Ca2+ store generates localized "Ca2+ bursts," which cross-..
  6. Parvalbumin-Containing Neurons in Schizophrenia
    Tsung Ung W Woo; Fiscal Year: 2013
    ..Hence, we will use immunoblot technique to examine two enzymes that promote oxidative stress, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox) and neuronal nitric oxide synthase (nNOS), and the catalytic and ..
  7. Novel Diagnostics to Detect Lung Injury
    Elizabeth R Jacobs; Fiscal Year: 2013
    ..The mitochondrial metabolic coenzymes Nicotinamide Adenine Dinucleotide (reduced form is NADH) and Flavine Adenine Dinucleotide (FAD) are the primary electron carriers in ..
  8. NAD Metabolism and Signaling
    Frances E Lund; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The vitamin B3-derived metabolite, nicotinamide adenine dinucleotide (NAD), and its related metabolites, NADH, NADP and NADPH, are best known as co-enzymes for hydride transfer enzymes that play ..
  9. Characterization of an essential mitochondrial rRNA methyltransferase
    Kip E Guja; Fiscal Year: 2013
    ..KsgA and Dim1 methyltransferases dimethylate two adjacent adenine residues in a conserved stem-loop in the small subunit of the bacterial and eukaryotic ribosomes, respectively...
  10. Nanoelectrode arrays for study of the molecular mechanisms, triggers, and inhibit
    Peter J Burke; Fiscal Year: 2012
    ..mitochondrial function: changes in the Akt signal transduction pathway, induction of hexokinase II, alteration an adenine nucleotide translocator (ANT) isoform expression, down regulation of the SOC2 cytochrome c oxidase (complex IV, ..
  11. Pathogenic Mechanisms of PBEF in Ventilator Induced Lung Injury
    Joe G N Garcia; Fiscal Year: 2012
    ..intracellular nicotinamide phosphoribosyltransferase (NamPT) with key enzymatic activity involved in nicotinamide adenine dinucleotide (NAD) biosynthesis...
  12. HYPOXIA AND CONTROL OF FETAL BREATHING MOVEMENTS
    Brian J Koos; Fiscal Year: 2010
    Extracellular adenine nucleotides, central adenosine (ADO) A2A receptors, and the parafascicular nuclear complex (Pf) of the thalamus are crucially involved in hypoxic inhibition of fetal breathing (FB)...
  13. Molecular Biology of Erythrocyte Ankyrin
    Patrick G Gallagher; Fiscal Year: 2010
    ..shift assays, DNAse-l footprinting and hypersensitive site mapping, methylation interference techniques, guanine-adenine ligation-mediated PCR dimethyl sulfate in vivo footprinting;chromatin immunoprecipitation;developmental-, tissue-,..
  14. Chemical approaches for studying the biology of CD38
    Hening Lin; Fiscal Year: 2013
    ..CD38 acts both as an enzyme and a receptor. The enzymatic activity can convert nicotinamide adenine dinucleotide (NAD) to adenosine diphosphate ribose (ADPR) and cyclic ADPR (cADPR), and NAD phosphate (NADP) to ..
  15. Gene-Targeted Pro-Drug Therapy for Colorectal Cancer
    Hiremagalur N Jayaram; Fiscal Year: 2013
    ..Our previous studies have shown that Tiazofurin is converted to an active form, Thiazole-4-carboxamide Adenine Dinucleotide (TAD) by the enzyme Nicotinamide 5'-Mononucleotide Adenylyltransferase (NMNAT)...
  16. DEVELOPMENT OF SPLIT DAMID AS AN ALTERNATIVE METHODOLOGY TO CHROMATIN IMMUNOPRECI
    Raphael Kopan; Fiscal Year: 2010
    ..Our solution (Split-DamID) relies on our ability to successfully split the bacterial DNA adenine methyltransferase (Dam) into N-terminal (D) and C-terminal (AM) halves...
  17. Purinergic Regulation of Bone Metabolism
    Bruce Neil Cronstein; Fiscal Year: 2013
    ..for adenosine generation during bone remodeling using animals deficient in the enzymes that convert extracellular adenine nucleotides to adenosine (NPP-1, TNAP, CD39 and CD73)...
  18. White Matter Protection in Cerebral Ischemia
    Guodong Cao; Fiscal Year: 2013
    ..primarily localizes in the cytosol and functions as the rate-limiting enzyme for the biosynthesis of nicotinamide adenine dinucleotide (NAD)14. NAMPT is neuroprotective against cerebral ischemia15,16...
  19. The role of human DNA polymerase eta in the mutagenic response to oxidative stres
    SCOTT DAVID MCCULLOCH; Fiscal Year: 2013
    ..This lesion is highly mutagenic due to its ability to base pair with the incorrect base adenine in a manner that escapes detection by the proofreading activity of the replicative polymerases...
  20. Correlative Multimodal Imaging of Cardiac Electrophysiology and Metabolism
    JOHN PETER contact WIKSWO; Fiscal Year: 2010
    ..K+]e;and reactive oxygen species, ROS;and ultraviolet autofluorescence measurement of reduced nicotinamide adenine dinucleotide, NADH;b) using biochemical assays to independently quantify the temporal variation of the cardiac ..
  21. The role of two-pore channels in integrative calcium signaling
    Michael X Zhu; Fiscal Year: 2013
    ..second messengers, inositol 1,4,5-trisphosphate (IP3), cyclic ADP- ribose (cADPR), and nicotinic acid adenine dinucleotide phosphate (NAADP), NAADP is least characterized...
  22. Regulation of guanylyl cyclase A and B by hormones, ATP and phosphorylation
    Lincoln Ross Potter; Fiscal Year: 2013
    ..b>Adenine nucleotides regulate GC-A and GC-B by binding unidentified intracellular high affinity activation and low ..
  23. RNA Modification Enzymes: Methyltransferase/psi-synthase
    Robert M Stroud; Fiscal Year: 2012
    ..Finally, we seek to determine the structure of a human tRNA adenine MTase as a potential new anti-HIV drug target...
  24. Nitrite Mediated Cardioprotection
    DAVID JOSEPH LEFER; Fiscal Year: 2012
    ..of NO is critically influenced by various cofactors such as tetrahydrobiopterin, flavin mononucleotide and flavin adenine dinucleotide, the presence of reduced thiols, and the endogenous NOS inhibitor asymmetric dimethylarginine (ADMA),..
  25. Role of the ribosomal stalk in the activity of Shiga toxins
    Nilgun E Tumer; Fiscal Year: 2013
    ..The A subunit is an N-glycosidase that specifically removes an adenine from the [unreadable]-sarcin/ricin loop (SRL) of 28S rRNA, resulting in inhibition of protein synthesis. E...
  26. Molecular and functional properties of the TRPM2 catioin channel
    Reinhold Penner; Fiscal Year: 2010
    ..Here, the novel calcium-release compound cADPR and other adenine dinucleotides materialize as crucial factors in TRPM2 physiology and hence processes involving cellular calcium ..
  27. Insulin Clearance: Candidate and Positional Genetic Determinants
    MARK GOODARZI; Fiscal Year: 2012
    ..Thus, the hypothesis underlying this proposal is that genes involved in the interconversion of adenine nucleotides (AMP, ADP, ATP) and cellular response to these molecules (AMPK system) are determinants of insulin ..
  28. INFLAMMATORY RESPONSES IN THE TOXICITY OF RICIN
    Bruce Magun; Fiscal Year: 2009
    ..Ricin is a member of a family of ribosome-directed toxins whose toxicity stems from the depurination of a single adenine within the "sarcin/ricin" loop of 28S ribosomal RNA (28S rRNA)...
  29. Linkage of Lung Inflammation to 8-oxoguanine and OGG1
    ISTVAN STEVEN BOLDOGH; Fiscal Year: 2013
    ..It is a premutagenic lesion in DNA because of its mispairing potential with adenine during replication...
  30. Investigating gene x environment interaction using human exposures to O3 & LPS
    David B Peden; Fiscal Year: 2010
    ..sufficient and single nucleotide polymorphisms (SNPs) for nicotinamide adenine dinucleotide (phosphate) reduced:quinone oxidoreductase (NQO1), with the resulting haplotypes...
  31. Diphthamide biosynthesis
    Hening Lin; Fiscal Year: 2012
    ..These toxins catalyze the transfer of an adenosine diphosphate ribose (ADP-ribose) from nicotinamide adenine dinucleotide (NAD) to one of the nitrogen atoms in the imidazole ring...
  32. Targeting NAD Metabolism to Improve Glucose Homeostasis in Obesity and Aging
    Joseph A Baur; Fiscal Year: 2013
    ..NAD Metabolism to Improve Glucose Homeostasis in Obesity and Aging We will test the hypothesis that nicotinamide adenine dinucleotide (NAD) metabolism can be targeted to improve physiology in aged or obese individuals...
  33. Mechanisms and Modulation of Cell Death in Traumatic Brain Injury
    ALAN IRA FADEN; Fiscal Year: 2012
    ..conditions, in association with activation of poly-ADP-ribose polymerase I (PARP-1) and reduction of nicotinamide adenine dinucleotide (NAD+)...
  34. Genetic analysis of DNA methylation in Neurospora crassa
    ANDREW DAVID KLOCKO; Fiscal Year: 2013
    ..DamID experiments using translational fusions to the bacterial DNA Adenine Methylase (dam) gene will analyze the genomic localization of this protein...
  35. Cytokines and Sympathetic Activation in Heart Failure
    Robert B Felder; Fiscal Year: 2013
    ..implicated inflammatory mechanisms that generate reactive oxygen species, particularly activation of nicotinamide adenine dinucleotide phosphate [NAD(P)H] oxidase dependent superoxide, in cardiovascular regions of the brain...
  36. CELLULAR PATHOPHYSIOLOGY OF ACUTE RENAL FAILURE
    Joel M Weinberg; Fiscal Year: 2012
    ..has shown that the deficit cannot be readily explained by abnormalities of mitochondrial electron transport, the adenine nucleotide translocase or the F1FO-ATPase...
  37. Pharmacogenomics of Human P450 Oxidoreductase
    Walter L Miller; Fiscal Year: 2012
    ..POR is a 680 amino-acid, 78 kDa protein that contains two flavins, a flavin adenine dinucleotide moiety (FAD), and a flavin mononucleotide (FMN)...
  38. In vivo 2-photon imaging of NADH in health and disease
    Anna Devor; Fiscal Year: 2012
    ..metabolism of single brain cells, taking advantage of intrinsic fluorescence of metabolic cofactor 2-nicotinamide adenine dinucleotide (NADH)...
  39. MOLECULAR REGULATION OF MUSCLE GLUCOSE METABOLISM IN MAN
    Lawrence J Mandarino; Fiscal Year: 2013
    ..Using these techniques we also propose 3) to determine how acetylation of mitochondrial adenine nucleotide translocase (ANT1) at lysines 10, 23, and 92 regulates ANT1 structure and function...
  40. Imaging Mitochondrial Redox States In Vivo by Hyperpolarized MR
    Lin Z Li; Fiscal Year: 2013
    ..Mitochondrial NAD (nicotinamide adenine dinucleotide)-coupled redox potential NAD+/NADH regulates a number of oxidation-reduction reactions in metabolism,..
  41. Non-invasive Assessment of Tissue Engineered Human Oral Mucosa
    Mary Ann Mycek; Fiscal Year: 2012
    ..metabolic activity of the cellular component of the EVPOME via the redox state of endogenous fluorophores flavin adenine dinucleotide (FAD) and nicotinamide adenine dinucleotide (NADH)...
  42. Genetic Analysis of Purine Metabolism in Leishmania donovani
    Buddy Ullman; Fiscal Year: 2013
    ..donovani and that adenine aminohydrolase (AAH), an enzyme unique to the parasite, plays a central role in purine interconversion within the ..
  43. The regulatory function of DNA methylation in Mycobacterium tuberculosis
    SCARLET SARA SHELL; Fiscal Year: 2012
    ..Specific aims: (1) Comprehensively identify sites of adenine methylation by Mrh (Methyltransferase Required in Hypoxia) in the Mtb genome;(2) Test the functional significance ..
  44. The Role of PARP-1 in Hormone-Regulated Transcription
    WILLIAM L KRAUS; Fiscal Year: 2013
    ..that catalyzes the polymerization of poly (ADP-ribose) (PAR) chains on target proteins from donor nicotinamide adenine dinucleotide (NAD+) molecules...
  45. Mechanisms of Intracellular NAMPT-regulated GSNOR in Vessel Wall
    ADAM CARL STRAUB; Fiscal Year: 2012
    ..enriched expression of nicotinamide phoshoribosyltransferase (NAMPT), a rate-limiting enzyme in the nicotinamide adenine dinucleotide (NAD) biosynthesis pathway...
  46. Mechanisms of Intracellular NAMPT-regulated GSNOR in Vessel Wall
    ADAM CARL STRAUB; Fiscal Year: 2013
    ..enriched expression of nicotinamide phoshoribosyltransferase (NAMPT), a rate-limiting enzyme in the nicotinamide adenine dinucleotide (NAD) biosynthesis pathway...
  47. Mutagenesis of p53 by reactive PAH and ROS
    JEFFREY M FIELD; Fiscal Year: 2012
    ..The yeast reporter system for p53 relies on wild-type p53 binding to a promoter to drive an adenine reporter causing mutant colonies turn red...
  48. The role of tristetraprolin in control of breast cancer progression
    Jianguo Liu; Fiscal Year: 2013
    ..TTP binds to adenine-uridine-rich elements (AREs) within the 3'untranslated region (3'UTR) causing destabilization of mRNAs ..
  49. Cell Death/Survival After Global Cerebral Ischemia
    Pak H Chan; Fiscal Year: 2013
    ..in p53- mediated hippocampal neuronal death after tGCI;and 3) to elucidate the role of reduced nicotinamide-adenine dinucleotide phosphate oxidase in hippocampal CA1 death and its crosstalk in p53 signaling after tGCI...
  50. In Vivo Imaging Alzheimers Disease Pathology with 2-Photon/Lifetime Microscopy
    MOHAMMAD ABBAS YASEEN; Fiscal Year: 2013
    ..calcium concentration ([Ca]) and measuring the reduced form of the endogenous electron carrier nicotinamide adenine dinucleotide (NADH), reportedly allowing the distinction of NADH species involved in glycolysis from NADH species ..
  51. Developing Male Contraceptives by Targeting ANT4
    Naohiro Terada; Fiscal Year: 2013
    ..b>Adenine nucleotide translocase (Ant) facilitates ADP/ATP exchange across the mitochondrial inner membrane, thus making it ..
  52. DNA damage repair by MUTYH and MUTYH variants associated with colorectal cancer
    SHEILA SUE DAVID; Fiscal Year: 2013
    ..of mutations associated with 8-oxo-7,8-dihydro-2'-deoxyguanosine (OG) by removal of misincorporated adenine residues from OG:A mismatches...
  53. Role of Inhibitory SMADs in Calcific Aortic Valve Disease
    Yin Tintut; Fiscal Year: 2013
    ..Oxidant stress and inflammation will be induced by oxidized lipids and TNF- in vitro and by an adenine diet in vivo...
  54. Brain epigenetic mechanisms in alcohol dependence
    SUBHASH PANDEY; Fiscal Year: 2009
    ..the class III HDACs [silent information regulator 2(Sir2) protein family] which requires a cofactor, nicotinamide-adenine dinucleotide (NAD), for enzymatic activity...
  55. Technologies for mapping interspersed AGG sequences in the FMR1 gene
    LIANGJING CHEN CHEN; Fiscal Year: 2010
    ..mutation state can occur when permutation repeats are in the "gray zone" (~30-50 CGG repeats), but interspersed adenine-guanine-guanine (AGG) sequences in the proper locations can confer stability to the gene...
  56. Metabolic Imaging of the Cardioprotective Effects of Alcohol and ALDH2 Activators
    Daniel M Spielman; Fiscal Year: 2013
    ..preliminary studies demonstrate that the flux of pyruvate-to-lactate is highly sensitive to coenzyme nicotinamide adenine dinucleotide (NADH) levels...
  57. Excision of Carcinogen-DNA Adducts in Nucleosomes
    Nicholas E Geacintov; Fiscal Year: 2013
    ..PAH are metabolically activated to reactive diol epoxide intermediates that react predominantly with guanine and adenine in cellular DNA to form pre-mutagenic covalent adducts in mammalian cells and tissues that can, if not repaired, ..
  58. Poly(ADP-ribose)Polymerase 1 Regulates Nucleolar Structure and Functions
    ERNEST KOJO BOAMAH; Fiscal Year: 2012
    ..PARP1 utilizes nicotinamide adenine dinucleotide (NAD+) as a substrate to generate (ADP) ribose (ADPr) to modify acceptor proteins...
  59. ADP: A Master Regulator for Bioenergetics and Ca2+/ROS Signaling in Heart
    Shey Shing Sheu; Fiscal Year: 2012
    ..Although the molecular identity of mPTP is still unsolved, 2 different concepts stand out. One indicates that adenine nucleotide translocase (ANT) is not required for mPTP, whereas the other depicts mPTP as a multi-protein complex, ..
  60. Pressure and Flow-Induced Remodeling of Coronary Arteries
    Ghassan S Kassab; Fiscal Year: 2010
    ..by increase in pressure (hypertension) or dilatation (FO) affects the AT1R which in turn upregulates Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase system...
  61. ADDUCTS AS QUANTITATIVE MARKERS OF BUTADIENE MUTAGENESIS
    James Swenberg; Fiscal Year: 2009
    ..The second hypothesis is that promutagenic N1 adenine adducts convert to the more stable inosine adducts which are poorly repaired and accumulate during chronic ..
  62. Role of Tat and SIRT1 in the T-cell Hyperactivation Syndrome Induced by HIV-1
    MELANIE MARIA OTT; Fiscal Year: 2013
    ..SIRT1 is a nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase and an important regulator of the transcription factor NF-B...
  63. NAD & CD38 Form a Communication System in the Retina
    Robert Miller; Fiscal Year: 2006
    ..activates CD38 to produce internalized second-messengers, such as cyclic ADP- ribose (cADPR)and/or nicotinic acid adenine dinucleotide phosphate (NAADP)...
  64. MEMBRANE-LIMITED METABOLISM IN MAMMALIAN RED CELLS
    Hyun Kim; Fiscal Year: 1990
    ..However, inosine by itself cannot replenish the purine moiety of adenine nucleotides. To turnover adenine nucleotides the red cells must encounter adenosine or adenine...
  65. ONTOGENY AND HORMONAL CONTROL OF CARDIAC NADH SHUTTLES
    Thomas Scholz; Fiscal Year: 2001
    ..Cytosolic reduced nicotinamide adenine dinucleotide (NADH) produced during the oxidation of glucose and lactate must be re-oxidize for glycolytic ATP ..
  66. AZIDE TECHNOLOGY FOR DRUG DEVELOPMENT
    Kyoichi Watanabe; Fiscal Year: 2001
    ..and colleagues reported that 6-azidopurine arabinoside can be reduced by NADPH- cytochrome P450 reductase to adenine arabinoside (arabinosyl adenine, ara-A or Vidarabine)...
  67. DNA METHYLATION AND PILI GENE REGULATION
    David Low; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): The goal of this proposal is to understand the mechanisms by which DNA adenine methylase (DAM), leucine-responsive regulatory protein (Lrp), and PapI orchestrate the reversible switch between OFF and ..
  68. Control of Cardiac Metabolism: NADH Shuttles/Hypertrophy
    Thomas Scholz; Fiscal Year: 2006
    ..of glucose and lactate, typical fuels in the neonatal and hypertrophied hearts, generates reduced nicotinamide adenine dinucleotide (NADH) that must be oxidized in order to maintain the cytosolic redox state...