nalidixic acid

Summary

Summary: A synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE.

Top Publications

  1. ncbi Comparison of the prevalence and changing resistance to nalidixic acid and ciprofloxacin of Shigella between Europe-America and Asia-Africa from 1998 to 2009
    Bing Gu
    Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road No 300, Nanjing 210029, China
    Int J Antimicrob Agents 40:9-17. 2012
  2. ncbi Two distinct mutations in gyrA lead to ciprofloxacin and nalidixic acid resistance in Campylobacter coli and Campylobacter jejuni isolated from chickens and beef cattle
    T W Jesse
    Bacterial Epidemiology and Antimicrobial Resistance Research Unit, U S Department of Agriculture, Agricultural Research Service, Athens, GA 30605 2720, USA
    J Appl Microbiol 100:682-8. 2006
  3. pmc Suitable disk antimicrobial susceptibility breakpoints defining Salmonella enterica serovar Typhi isolates with reduced susceptibility to fluoroquinolones
    Christopher M Parry
    The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Vietnam
    Antimicrob Agents Chemother 54:5201-8. 2010
  4. ncbi Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals
    Yolanda Sáenz
    Área de Bioquímica y Biología Molecular, Universidad de La Rioja, Madre de Dios 51, 26006, Logrono, Spain
    J Antimicrob Chemother 51:1001-5. 2003
  5. pmc Isolation and molecular characterization of nalidixic acid-resistant extraintestinal pathogenic Escherichia coli from retail chicken products
    James R Johnson
    Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55417, USA
    Antimicrob Agents Chemother 47:2161-8. 2003
  6. ncbi Distribution and possible transmission of ampicillin- and nalidixic acid-resistant Escherichia coli within the broiler industry
    Valeria Bortolaia
    Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark
    Vet Microbiol 142:379-86. 2010
  7. ncbi Predictive efficacy of nalidixic acid resistance as a marker of fluoroquinolone resistance in Salmonella enterica var Typhi
    Pallab Ray
    Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Indian J Med Res 124:105-8. 2006
  8. ncbi Antibacterial activity of methyl gallate isolated from Galla Rhois or carvacrol combined with nalidixic acid against nalidixic acid resistant bacteria
    Jang Gi Choi
    Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Wonkwang Oriental Medicines Research Institute, Jeonbuk, Korea
    Molecules 14:1773-80. 2009
  9. ncbi The acquisition of full fluoroquinolone resistance in Salmonella Typhi by accumulation of point mutations in the topoisomerase targets
    Arthur K Turner
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SA, UK
    J Antimicrob Chemother 58:733-40. 2006
  10. ncbi Typhoid fever: a massive, single-point source, multidrug-resistant outbreak in Nepal
    Michael D Lewis
    Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Clin Infect Dis 40:554-61. 2005

Research Grants

Detail Information

Publications205 found, 100 shown here

  1. ncbi Comparison of the prevalence and changing resistance to nalidixic acid and ciprofloxacin of Shigella between Europe-America and Asia-Africa from 1998 to 2009
    Bing Gu
    Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road No 300, Nanjing 210029, China
    Int J Antimicrob Agents 40:9-17. 2012
    ..Statistical analyses were performed using STATA 10.0. In the area of Asia-Africa, resistance rates to nalidixic acid and ciprofloxacin were 33.6% [95% confidence interval (CI) 21.8-46.6%] and 5.0% (95% CI 2.8-7...
  2. ncbi Two distinct mutations in gyrA lead to ciprofloxacin and nalidixic acid resistance in Campylobacter coli and Campylobacter jejuni isolated from chickens and beef cattle
    T W Jesse
    Bacterial Epidemiology and Antimicrobial Resistance Research Unit, U S Department of Agriculture, Agricultural Research Service, Athens, GA 30605 2720, USA
    J Appl Microbiol 100:682-8. 2006
    ..point mutations in the gyrA quinolone resistance determining region (QRDR) of Campylobacter coli (n = 27) and Campylobacter jejuni (n = 26) that confer nalidixic acid (NAL) resistance without conferring resistance to ciprofloxacin (CIP).
  3. pmc Suitable disk antimicrobial susceptibility breakpoints defining Salmonella enterica serovar Typhi isolates with reduced susceptibility to fluoroquinolones
    Christopher M Parry
    The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Vietnam
    Antimicrob Agents Chemother 54:5201-8. 2010
    ..We examined 816 isolates of S. Typhi from seven Asian countries. Screening for nalidixic acid resistance (MIC ≥ 16 μg/ml) identified isolates with an ofloxacin MIC of ≥0...
  4. ncbi Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals
    Yolanda Sáenz
    Área de Bioquímica y Biología Molecular, Universidad de La Rioja, Madre de Dios 51, 26006, Logrono, Spain
    J Antimicrob Chemother 51:1001-5. 2003
    Mutations in quinolone targets were analysed in 80 unrelated nalidixic acid-resistant (NALR) Escherichia coli strains whose nalidixic acid and ciprofloxacin MICs ranged from 32 to >256 mg/L and 0.03-64 mg/L, respectively...
  5. pmc Isolation and molecular characterization of nalidixic acid-resistant extraintestinal pathogenic Escherichia coli from retail chicken products
    James R Johnson
    Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55417, USA
    Antimicrob Agents Chemother 47:2161-8. 2003
    ..Paul area (1999 to 2000) were screened for nalidixic acid (Nal)-resistant E. coli. Sixty-two (37%) products yielded Nal-resistant E. coli...
  6. ncbi Distribution and possible transmission of ampicillin- and nalidixic acid-resistant Escherichia coli within the broiler industry
    Valeria Bortolaia
    Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark
    Vet Microbiol 142:379-86. 2010
    ..coli resistant to ampicillin and nalidixic acid were frequently isolated, while resistance to ciprofloxacin was detected at a very low frequency, and ..
  7. ncbi Predictive efficacy of nalidixic acid resistance as a marker of fluoroquinolone resistance in Salmonella enterica var Typhi
    Pallab Ray
    Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Indian J Med Res 124:105-8. 2006
    ..Typhi, not detectable by disc diffusion (DD) tests, may result in delayed response and serious complications. Nalidixic acid (NA) resistance has been used as an indirect evidence of increased ciprofloxacin MIC in S. Typhi...
  8. ncbi Antibacterial activity of methyl gallate isolated from Galla Rhois or carvacrol combined with nalidixic acid against nalidixic acid resistant bacteria
    Jang Gi Choi
    Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Wonkwang Oriental Medicines Research Institute, Jeonbuk, Korea
    Molecules 14:1773-80. 2009
    ..This study investigated the antibacterial activities of nalidixic acid in combination with methyl gallate and carvacrol against nalidixic acid resistant bacteria...
  9. ncbi The acquisition of full fluoroquinolone resistance in Salmonella Typhi by accumulation of point mutations in the topoisomerase targets
    Arthur K Turner
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SA, UK
    J Antimicrob Chemother 58:733-40. 2006
    ..To determine the contribution to fluoroquinolone resistance of point mutations in the gyrA and parC genes of Salmonella Typhi...
  10. ncbi Typhoid fever: a massive, single-point source, multidrug-resistant outbreak in Nepal
    Michael D Lewis
    Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Clin Infect Dis 40:554-61. 2005
    ....
  11. ncbi In vitro efficacy of the combination of ciprofloxacin and cefotaxime against nalidixic acid-resistant Salmonella enterica serotype Typhi
    Dong Min Kim
    Division of Infectious Diseases, Department of Internal Medicine, Chosun University College of Medicine, Clinical Research Institute, Gwangju, South Korea
    Int J Antimicrob Agents 36:155-8. 2010
    ..The emergence and spread of nalidixic acid-resistant S...
  12. ncbi Sorption of acetaminophen, 17alpha-ethynyl estradiol, nalidixic acid, and norfloxacin to silica, alumina. and a hydrophobic medium
    Oranuj Lorphensri
    National Research Center for Environmental and Hazardous Waste Management, Chulalongkorn University, Bangkok, Thailand
    Water Res 40:1481-91. 2006
    ..sorption of four pharmaceuticals, acetaminophen (analgesic), 17alpha-ethynyl estradiol (synthetic hormone), nalidixic acid (antibiotic), and norfloxacin (antibiotic), was evaluated with silica, alumina, and Porapak P (a hydrophobic ..
  13. ncbi Interaction of nalidixic acid and ciprofloxacin with wild type and mutated quinolone-resistance-determining region of DNA gyrase A
    Jitendra Vashist
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110029, India
    Indian J Biochem Biophys 46:147-53. 2009
    ..of GyrA with respect to quinolone binding, we have studied the interaction of mutated QRDR of GyrA with nalidixic acid and ciprofloxacin by molecular modeling using GLIDE v4...
  14. pmc Nalidixic acid-resistant Salmonella enterica serotype Typhi presenting as a primary psoas abscess: case report and review of the literature
    William A Shakespeare
    University of Utah School of Medicine, University of Hospitals and Clinics, Salt Lake City, UT, USA
    J Clin Microbiol 43:996-8. 2005
    ..The isolate tested susceptible to ciprofloxacin but resistant to nalidixic acid in vitro, a pattern associated with fluoroquinolone therapeutic failures...
  15. ncbi Nalidixic acid resistance in Salmonella strains with decreased susceptibility to ciprofloxacin isolated from humans in Turkey
    Serpil Ercis
    Department of Microbiology and Clinical Microbiology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Jpn J Infect Dis 59:117-9. 2006
    The aim of this study was to evaluate the value of nalidixic acid resistance as an indicator of decreased susceptibility to ciprofloxacin (MIC = 0.125 - 1 mg/L) in Salmonella isolates from humans (n = 620) in Turkey...
  16. pmc Clinical outcomes in typhoid fever: adverse impact of infection with nalidixic acid-resistant Salmonella typhi
    Tamilarasu Kadhiravan
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    BMC Infect Dis 5:37. 2005
    ..These strains are identifiable by their nalidixic acid-resistance. We studied the impact of infection with nalidixic acid-resistant S...
  17. pmc The epsilon subunit of DNA polymerase III Is involved in the nalidixic acid-induced SOS response in Escherichia coli
    Jennifer Reineke Pohlhaus
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Bacteriol 190:5239-47. 2008
    Quinolone antibacterial drugs such as nalidixic acid target DNA gyrase in Escherichia coli...
  18. ncbi Characterization of the quinolone resistance mechanism in foodborne Salmonella isolates with high nalidixic acid resistance
    Koo Youn Kim
    Food Safety and Evaluation Laboratory, Department of Food Bioscience and Technology, Korea University, Anam Dong 5 Ga, Seongbuk gu, Seoul 136 713, Republic of Korea
    Int J Food Microbiol 146:52-6. 2011
    Sixteen Salmonella strains resistant to nalidixic acid isolated from kimbab, the most popular ready-to-eat (RTE) food in Korea, and chicken meat were selected for this study...
  19. ncbi Effect of nalidixic acid on the morphology and protein expression of Pseudomonas aeruginosa
    Saif Al Bahry
    Department of Biology, College of Science, P O Box 36, P C 123, Sultan Qaboos University, Sultanate of Oman
    Asian Pac J Trop Med 5:265-9. 2012
    To determine the effect of nalidixic acid on the morphology and protein expression of Pseudomonas aeruginosa (P. aeruginosa).
  20. ncbi Synthesis of novel nalidixic acid-based 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives as potent antibacterial agents
    Nisha Aggarwal
    Division of Agricultural Chemicals, Indian Agricultural Research Institute, Pusa Campus, New Delhi 110 012, India
    Chem Biol Drug Des 79:384-97. 2012
    Novel nalidixic acid-based 1,3,4-thia(oxa)diazoles, their thio ethers, sulfones, bis mercapto, and Mannich bases were synthesized and characterized by Infrared spectra, (1) H NMR, (13) C NMR, and elemental analysis...
  21. ncbi Schiff bases of indoline-2,3-dione (isatin) derivatives and nalidixic acid carbohydrazide, synthesis, antitubercular activity and pharmacophoric model building
    Tarek Aboul-Fadl
    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P O Box 2457 Riyadh 14511, Saudi Arabia
    Eur J Med Chem 45:4578-86. 2010
    ..Accordingly, the current work involved design and synthesis of Schiff bases of nalidixic acid carbohydrazide and isatin derivatives (5,6a-f and 7,8a-c)...
  22. ncbi Emergence of nalidixic acid resistance in Shigella sonnei isolated from patients having acute diarrheal disease: report from eastern province of Saudi Arabia
    Bodh Raj Panhotra
    Division of Microbiology, Postgraduate Department of Medicine, King Fahad Hospital and Tertiary Care Center, Al Hasa 31982, Saudi Arabia
    Jpn J Infect Dis 57:116-8. 2004
    ..Shigella sonnei phase 1 was the most prevalent (88/110, 80.0%) serotype. Resistance to nalidixic acid was not encountered from 1999-2002. Nalidixic acid resistance was observed in 6/13 (46.1%) of the S...
  23. ncbi Effect of an efflux pump inhibitor on the MIC of nalidixic acid for Acinetobacter baumannii and Stenotrophomonas maltophilia clinical isolates
    Anna Ribera
    J Antimicrob Chemother 49:697-8. 2002
  24. ncbi In vivo selection during ofloxacin therapy of Escherichia coli with combined topoisomerase mutations that confer high resistance to ofloxacin but susceptibility to nalidixic acid
    Vincent Cattoir
    Service de Bactériologie Virologie Hygiène, AP HP CHU, Henri Mondor Université Paris XII, 51 Avenue du Marechal de Lattre de Tassigny, 94010 Creteil Cedex, France
    J Antimicrob Chemother 58:1054-7. 2006
    To investigate quinolone resistance mechanisms in an Escherichia coli clinical isolate (Ar2) resistant to ofloxacin but susceptible to nalidixic acid selected after 10 days of ofloxacin therapy in a patient with prostatitis.
  25. ncbi High level of resistance to nalidixic acid in Salmonella enterica serovar Typhi in Central India
    Yashwant Kumar
    National Salmonella and Escherichia Centre, Central Research Institute, Himachal Pradesh, India
    J Infect Dev Ctries 3:467-9. 2009
    ..b>Nalidixic acid resistance has been used as an indirect evidence of increased minimum inhibitory concentration for ..
  26. pmc Treatment failure in a typhoid patient infected with nalidixic acid resistant S. enterica serovar Typhi with reduced susceptibility to ciprofloxacin: a case report from Cameroon
    Njinkeng J Nkemngu
    St John s Maternity and Hospital, Fiango, Kumba, Cameroon
    BMC Infect Dis 5:49. 2005
    ..Treatment failure with fluoroquinolones has been reported in Asia and Europe. We report a case of ciprofloxacin treatment failure in typhoid fever in Cameroon...
  27. ncbi Nalidixic acid susceptibility test to screen ciprofloxacin resistance in Salmonella typhi
    Arti Kapil
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 115:49-54. 2002
    ..We explored the possibility of testing S. typhi strains for their susceptibility to nalidixic acid by disc diffusion method as a marker for high MIC to ciprofloxacin.
  28. pmc Increasing prevalence of quinolone resistance in human nontyphoid Salmonella enterica isolates obtained in Spain from 1981 to 2003
    José M Marimón
    Servicio de Microbiologia, Hospital Donostia, Paseo Dr Beguiristain s n, 20014 San Sebastian, Spain
    Antimicrob Agents Chemother 48:3789-93. 2004
    From January 1981 to December 2003, susceptibility to nalidixic acid was tested in 10,504 nontyphoid Salmonella enterica isolates from patients with acute enteric disease in Gipuzkoa, Spain...
  29. pmc Epidemiological study of resistance to nalidixic acid and other antibiotics in clinical Yersinia enterocolitica O:3 isolates
    S Capilla
    Department of Microbiology, Faculty of Medicine, University of Zaragoza, 50009 Zaragoza, Spain
    J Clin Microbiol 41:4876-8. 2003
    Forty-six Yersinia enterocolitica O:3 clinical isolates resistant to nalidixic acid were studied...
  30. pmc Differential effects of temperature on natural transformation to erythromycin and nalidixic acid resistance in Campylobacter coli
    Joo Sung Kim
    North Carolina State University, Department of Food Science, Raleigh, NC 27695, USA
    Appl Environ Microbiol 74:6121-5. 2008
    ..coli to erythromycin and nalidixic acid resistance...
  31. pmc Clonal dissemination of Yersinia enterocolitica strains with various susceptibilities to nalidixic acid
    Javier Sanchez-Cespedes
    Servei de Microbiologia, Institut Clinic Infeccions i Immunologia, IDIBAPS, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain
    J Clin Microbiol 41:1769-71. 2003
    Ten epidemiologically related Yersinia enterocolitica clinical isolates were studied. Six isolates were nalidixic acid resistant (MIC > 512 microg/ml), with mutations in the quinolone resistance-determining region (QRDR) of the gyrA gene, ..
  32. pmc Reduced fluoroquinolone susceptibility in Salmonella enterica serotypes in travelers returning from Southeast Asia
    A Hakanen
    Antimicrobial Research Laboratory, National Public Health Institute, Turku, Finland
    Emerg Infect Dis 7:996-1003. 2001
    ..These isolates were tested for susceptibility by determining MICs to ciprofloxacin, nalidixic acid, and seven additional antimicrobial agents...
  33. pmc Emerging quinolone-resistant Salmonella in the United States
    H Herikstad
    Centers for Disease Control and Prevention, Atlanta, Gerogia, USA
    Emerg Infect Dis 3:371-2. 1997
    ..States during this period was tested for resistance to 12 antimicrobial agents, including two quinolones, nalidixic acid, and ciprofloxacin. Emerging quinolone resistance was detected; of 4,008 isolates tested, 21 (0...
  34. ncbi The treatment of multidrug-resistant and nalidixic acid-resistant typhoid fever in Viet Nam
    Christopher M Parry
    Oxford University Wellcome Trust Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
    Trans R Soc Trop Med Hyg 98:413-22. 2004
    ..and isolates with reduced susceptibility to fluoroquinolones (indicated by resistance to nalidixic acid, NaR) have caused epidemics and become endemic in southern Viet Nam during the 1990s...
  35. ncbi Nalidixic acid-resistant Salmonella enterica serovar Typhi with decreased susceptibility to ciprofloxacin caused treatment failure: a report from Bangladesh
    S M Zahurul Haque Asna
    Department of Microbiology, Chittagong Medical College, Chittagong, Bangladesh
    Jpn J Infect Dis 56:32-3. 2003
  36. ncbi Validity of nalidixic acid screening in fluoroquinolone-resistant typhoid salmonellae
    Tariq Butt
    Department of Pathology, Combined Military Hospital, Peshawar, Pakistan
    J Coll Physicians Surg Pak 16:31-4. 2006
    To validate the screening of low-level fluoroquinolone resistance in typhoid salmonellae by using nalidixic acid (30 mg) disk providing an acceptable zone of inhibition.
  37. ncbi Synthesis and evaluation of new quinazolone derivatives of nalidixic acid as potential antibacterial and antifungal agents
    Gaurav Grover
    Clinical Research and Medical Services, LG Life Sciences India Pvt Ltd, LG House, AB 3, Safdarjung Enclave, New Delhi 110069, India
    Eur J Med Chem 41:256-62. 2006
    ..on synthesis of biheterocycles carrying the biodynamic heterocyclic systems at position 3, a series of new nalidixic acid derivatives having quinazolones moiety were synthesised to achieve enhanced biological activity and wide ..
  38. ncbi Predictive value of nalidixic acid resistance for detecting salmonellae with decreased ciprofloxacin susceptibility
    F Albayrak
    Ankara University Medical Faculty Clinical Bacteriology and Infectious Diseases Department, Ilkadim Mahallesi Seçkin Sokak No 18 4, 06450 Dikmen, Ankara, Turkey
    Int J Antimicrob Agents 23:332-6. 2004
    ..when using the criteria of the National Committee for Clinical Laboratory Standards were studied for nalidixic acid (NA) resistance...
  39. pmc Increase in nalidixic acid resistance among non-Typhi Salmonella enterica isolates in the United States from 1996 to 2003
    Jennifer E Stevenson
    Centers for Disease Control and Prevention, Mailstop D63, 1600 Clifton Rd, Atlanta, GA 30333, USA
    Antimicrob Agents Chemother 51:195-7. 2007
    ..Fluoroquinolone treatment has failed for persons infected with nalidixic acid-resistant Salmonella...
  40. pmc Genetic analysis of the requirements for SOS induction by nalidixic acid in Escherichia coli
    Kathryn G Newmark
    Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    Gene 356:69-76. 2005
    b>Nalidixic acid, the prototype antibacterial quinolone, induces the SOS response by a mechanism that requires the RecBCD nuclease/helicase...
  41. ncbi Emergence of nalidixic acid-resistant Salmonella enterica serovar Typhi resistant to ciprofloxacin in India
    Hayath Kownhar
    J Med Microbiol 56:136-7. 2007
  42. pmc Detection of decreased fluoroquinolone susceptibility in Salmonellas and validation of nalidixic acid screening test
    A Hakanen
    Antimicrobial Research Laboratory, National Public Health Institute, Turku University, Turku, Finland
    J Clin Microbiol 37:3572-7. 1999
    ..according to the National Committee for Clinical Laboratory Standards guidelines for susceptibility to nalidixic acid and three fluoroquinolones...
  43. pmc Randomized controlled comparison of ofloxacin, azithromycin, and an ofloxacin-azithromycin combination for treatment of multidrug-resistant and nalidixic acid-resistant typhoid fever
    Christopher M Parry
    Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
    Antimicrob Agents Chemother 51:819-25. 2007
    ..ampicillin, and trimethoprim-sulfamethoxazole) and have reduced susceptibility to fluoroquinolones (nalidixic acid resistant, Na(r)) are common in Asia...
  44. pmc Lon protease is essential for paradoxical survival of Escherichia coli exposed to high concentrations of quinolone
    Muhammad Malik
    Public Health Research Institute, New Jersey Medical School, UMDNJ, 225 Warren Street, Newark, NJ 07103, USA
    Antimicrob Agents Chemother 53:3103-5. 2009
    A deficiency of the Escherichia coli Lon protease blocked paradoxical survival occurring at very high nalidixic acid concentrations. The absence of Lon also blocked a parallel increase in cell lysate viscosity likely to reflect DNA size...
  45. ncbi Toxicity and SOS-response to ELF magnetic fields and nalidixic acid in E. coli cells
    Igor Belyaev
    Laboratory of Molecular Genetics, Cancer Research Institute, Bratislava, Slovak Republic
    Mutat Res 722:56-61. 2011
    ..The genotoxic agent nalidixic acid (NAL) was used as a positive control and in combination with ELF-MF...
  46. ncbi Positive adaptive state: microarray evaluation of gene expression in Salmonella enterica Typhimurium exposed to nalidixic acid
    Scot E Dowd
    United States Department of Agriculture, Agricultural Research Service, Livestock Issues Research Unit, Lubbock, Texas 79403, USA
    Foodborne Pathog Dis 4:187-200. 2007
    ..6 microg/mL of nalidixic acid. The results showed a significant (P < 0.02) difference (fold expression differences >2...
  47. ncbi Is nalidixic acid resistance linked to clinical virulence in Salmonella enterica serovar Typhi infections?
    Tamilarasu Kadhiravan
    J Med Microbiol 57:1046-8. 2008
  48. ncbi Comparison of pivmecillinam and nalidixic acid in the treatment of acute shigellosis in children
    A N Alam
    International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Scand J Gastroenterol 29:313-7. 1994
    The efficacy of oral pivmecillinam was compared with nalidixic acid in the treatment of acute shigellosis in children 1-8 years of age...
  49. ncbi Ciprofloxacin resistance in non-typhoidal Salmonella serotypes in Scotland, 1993-2003
    A Murray
    Scottish Salmonella Reference Laboratory, Stobhill Hospital, Glasgow, UK
    J Antimicrob Chemother 56:110-4. 2005
    ..To determine the levels of resistance to ciprofloxacin among non-typhoidal salmonellae in Scotland...
  50. ncbi Increasing incidence of resistance to nalidixic acid in shigellas from humans in England and Wales: implications for therapy
    T Cheasty
    Health Protection Agency, Specialist and Reference Microbiology Division, Laboratory of Enteric Pathogens, London, UK
    Clin Microbiol Infect 10:1033-5. 2004
    ..and Wales in 2002, 10% of subgroups A, B and C, and 13% of subgroup D (Shigella sonnei), were resistant to nalidixic acid. As a consequence, should antimicrobial therapy be indicated, the efficacy of nalidixic acid as the preferred ..
  51. ncbi Reevaluating fluoroquinolone breakpoints for Salmonella enterica serotype Typhi and for non-Typhi salmonellae
    John A Crump
    Foodborne and Diarrheal Diseases Branch, Div of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, MS A 38, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
    Clin Infect Dis 37:75-81. 2003
    ..Recently, resistance to nalidixic acid has emerged among both Typhi and non-Typhi Salmonella serotypes...
  52. ncbi Nalidixic acid-resistant mutations of the gyrB gene of Escherichia coli
    J Yamagishi
    Mol Gen Genet 204:367-73. 1986
    DNA fragments of 3.4 kb containing the gyrB gene were cloned from Escherichia coli KL-16 and from spontaneous nalidixic acid-resistant mutants...
  53. ncbi Synthesis of nalidixic acid based hydrazones as novel pesticides
    Nisha Aggarwal
    Department of Chemistry, University of Delhi, Delhi 110 007, India
    J Agric Food Chem 58:3056-61. 2010
    Thirty-one substituted hydrazones of nalidixic acid hydrazide were synthesized and characterized by spectral techniques...
  54. pmc Laboratory detection of Haemophilus influenzae with decreased susceptibility to nalidixic acid, ciprofloxacin, levofloxacin, and moxifloxacin due to GyrA and ParC mutations
    María Pérez-Vázquez
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Clin Microbiol 42:1185-91. 2004
    ..Collection reference strains of Haemophilus influenzae to ciprofloxacin, levofloxacin, moxifloxacin, and nalidixic acid by the microdilution and disk diffusion methods. The ciprofloxacin MICs for 34 of the isolates were >/=0...
  55. pmc Emergence of nalidixic acid-resistant Shigella sonnei in acute-diarrhea patients on Andaman and Nicobar Islands, India
    Asit R Ghosh
    Antimicrob Agents Chemother 47:1483. 2003
  56. ncbi Nalidixic acid-resistant strains of Salmonella showing decreased susceptibility to fluoroquinolones in the mid-west region of the Republic of Ireland
    Rachel Gorman
    J Antimicrob Chemother 51:1047-9. 2003
  57. ncbi Detection of ciprofloxacin resistance in Haemophilus influenzae using nalidixic acid and BSAC methodology
    Nigel P Brenwald
    J Antimicrob Chemother 51:1311-2. 2003
  58. pmc Molecular epidemiology of nalidixic acid-resistant campylobacter isolates from humans and poultry by pulsed-field gel electrophoresis and flagellin gene analysis
    T L Wu
    Department of Clinical Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Epidemiol Infect 129:227-31. 2002
    ..of human infections associated with quinolone-resistant campylobacters, 140 human and 75 poultry isolates of nalidixic acid-resistant campylobacters were collected between 1996 and 1998, and analysed by two molecular typing methods...
  59. pmc New quinolone resistance phenomenon in Salmonella enterica: nalidixic acid-susceptible isolates with reduced fluoroquinolone susceptibility
    Antti J Hakanen
    Antimicrobial Research Laboratory, National Public Health Institute, P O Box 57, 20521 Turku, Finland
    J Clin Microbiol 43:5775-8. 2005
    ..These isolates are susceptible to nalidixic acid but exhibit reduced susceptibility to ciprofloxacin...
  60. ncbi A 2'-acylamido cap that increases the stability of oligonucleotide duplexes
    O P Kryatova
    Departments of Chemistry, Tufts University, Medford, Massachusetts 02155, and University of Constance, D-78457 Konstanz, Germany
    Org Lett 3:987-90. 2001
    ..In the case of (5'-ACGCGU-NA-2')2, where NA denotes a nalidixic acid residue, the melting point increase is up to 22 degrees C over that of (ACGCGT)2.
  61. pmc Suboptimal clinical response to ciprofloxacin in patients with enteric fever due to Salmonella spp. with reduced fluoroquinolone susceptibility: a case series
    Robert Slinger
    Division of Infectious Disease, Children s Hospital of Eastern Ontario, 401 Smyth Rd, Ottawa, ON, Canada
    BMC Infect Dis 4:36. 2004
    ..Delayed treatment response to fluoroquinolones has been noted, especially in cases of enteric fever due to such strains. We reviewed the ciprofloxacin susceptibility and clinical outcome of our recent enteric fever cases...
  62. ncbi In vitro activity of gemifloxacin against clinical isolates of Neisseria gonorrhoeae with and without mutations in the gyrA gene
    Joaquim Ruiz
    Servei de Microbiologia, Institut Clinic d Infeccions i Immunologia, IDIBAPS, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
    Int J Antimicrob Agents 22:73-6. 2003
    ..Only seven strains were resistant to nalidixic acid due to a mutation in the gyrA gene but not in the parC gene, with six and two considered intermediate to ..
  63. ncbi Prevalence of quinolone resistance mechanisms and associations to minimum inhibitory concentrations in quinolone-resistant Escherichia coli isolated from humans and swine in Denmark
    Lina Maria Cavaco
    Research Group for Antimicrobial Resistance and Molecular Epidemiology, Department for Microbiology and Risk Assessment, National Food Institute, Technical University of Denmark, Copenhagen V, Denmark
    Microb Drug Resist 14:163-9. 2008
    Prevalence of quinolone resistance mechanisms and associations to minimum inhibitory concentrations (MICs) of nalidixic acid (NAL) and ciprofloxacin (CIP) were investigated in 124 Escherichia coli isolated from humans (n=85) and swine (n=..
  64. pmc Drug-resistant nontyphoidal Salmonella bacteremia, Thailand
    Wanla Kulwichit
    Emerg Infect Dis 13:501-2. 2007
  65. pmc Emergence of plasmid-mediated quinolone resistance in Escherichia coli in Europe
    Hedi Mammeri
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 49:71-6. 2005
    ..This is the first report of plasmid-mediated quinolone resistance in Europe associated with an unknown level of plasmid-mediated multidrug resistance in Enterobacteriaceae...
  66. ncbi Salmonella enterica serovar Typhi with decreased susceptibility to ciprofloxacin--an emerging problem in Bangladesh
    M Mushfequr Rahman
    Int J Antimicrob Agents 25:345-6. 2005
  67. ncbi Ciprofloxacin treatment failure in a case of typhoid fever caused by Salmonella enterica serotype Paratyphi A with reduced susceptibility to ciprofloxacin
    Tzonyo Dimitrov
    Department of Medical Laboratories, Microbiology Section, Infectious Diseases Hospital, and Department of Microbiology, Faculty of Medicine, Kuwait University, Safat 13048, Kuwait
    J Med Microbiol 56:277-9. 2007
    ..The organism showed reduced susceptibility to ciprofloxacin (MIC 0.75 microg ml-1) and was resistant to nalidixic acid. The patient was then placed on intravenous ceftriaxone (1 g every 12 h) and responded within 3 days...
  68. ncbi Characterization of Salmonella spp. mutants with reduced fluoroquinolone susceptibility: importance of efflux pump mechanisms
    Laura Cebrian
    S Microbiología, Hospital General Universitario de Elche, Universidad Miguel Hernandez, Elche, Espana
    Chemotherapy 51:40-3. 2005
    ..We studied the importance of the efflux pump mechanisms in Salmonella spp. mutants with reduced fluoroquinolone susceptibility generated in vitro...
  69. ncbi Campylobacter coli isolates derived from chickens in Senegal: Diversity, genetic exchange with Campylobacter jejuni and quinolone resistance
    Alfred Dieudonné Kinana
    Laboratoire de Biologie Medicale, Institut Pasteur de Dakar, 36, avenue Pasteur, Dakar, Senegal
    Res Microbiol 158:138-42. 2007
    ..In addition, we assessed the resistance of the isolates to ciprofloxacin and nalidixic acid, and their gyrA sequences. MLST revealed a low level of diversity and the absence of lineages among C...
  70. pmc Quinolone-resistant uropathogenic Escherichia coli strains from phylogenetic group B2 have fewer virulence factors than their susceptible counterparts
    Juan P Horcajada
    Service of Infectious Diseases, Hospital Clinic Universitari IDIBAPS, Villaroel 170, 08036 Barcelona, Spain
    J Clin Microbiol 43:2962-4. 2005
    The prevalence of 31 virulence factors was analyzed among nalidixic acid-susceptible and -resistant Escherichia coli strains from phylogenetic group B2...
  71. pmc Mechanism of drug resistance in clonally related clinical isolates of Vibrio fluvialis isolated in Kolkata, India
    Vijaya Bharathi Srinivasan
    Institute of Microbial Technology, Molecular Biology Division, Sector 39A, Chandigarh 160036, India
    Antimicrob Agents Chemother 50:2428-32. 2006
    ..In the presence of carbonyl cyanide m-chlorophenylhydrazone or reserpine, all nalidixic acid- and ciprofloxacin-resistant strains became sensitive, suggesting that drug efflux plays a major role in ..
  72. pmc Genetic diversity and quinolone resistance in Campylobacter jejuni isolates from poultry in Senegal
    Alfred Dieudonné Kinana
    Laboratoire de Biologie Medicale, Institut Pasteur de Dakar, 36 Avenue Pasteur, Dakar, Senegal
    Appl Environ Microbiol 72:3309-13. 2006
    ..Based on silent mutations, different variants of the gyrA gene were shown to exist for the same ST. These data provide useful information for understanding the epidemiology of C. jejuni in Senegal...
  73. ncbi Complete nucleotide sequence of the gyrA gene of Helicobacter pullorum and identification of a point mutation leading to ciprofloxacin resistance in poultry isolates
    Frédérique Pasquali
    Department of Food Science, Alma Mater Studiorum University of Bologna, San Giacomo 9, 40127 Bologna, Italy
    Int J Antimicrob Agents 30:222-8. 2007
    To assess the molecular basis of nalidixic acid and ciprofloxacin resistance in Helicobacter pullorum, the gyrA gene of H. pullorum CIP 104787T was sequenced...
  74. pmc qnrA in CTX-M-producing Escherichia coli isolates from France
    Jean Philippe Lavigne
    Laboratoire Universitaire d Antibiologie, UFR de Medecine, Avenue Kennedy, 30908 NIMES Cedex 02, France
    Antimicrob Agents Chemother 50:4224-8. 2006
    ..For the first time, 7.7% of CTX-M-producing E. coli isolates presented a plasmid-mediated resistance to quinolones. All strains harbored a qnrA gene located on a sul1-type class 1 integron with similar structure to the In36 integron...
  75. ncbi Genetic characterization and antibiotic resistance of Campylobacter spp. isolated from poultry and humans in Senegal
    E Cardinale
    Programme Productions Animales, CIRAD EMVT, Campus International de Baillarguet, Montpellier Cedex 5, France
    J Appl Microbiol 100:209-17. 2006
    ..The main objectives of this study were to investigate the diversity of Campylobacter genotypes circulating in Senegal and to determine the frequency of antibiotic resistance...
  76. ncbi Salmonella enterica serovar typhi: molecular analysis of strains with decreased susceptibility and resistant to ciprofloxacin in India from 2001-2003
    Malini R Capoor
    Department of Microbiology, Vardhman Mahaveer Medical College and Safdarjung Hospital, New Delhi, India
    Braz J Infect Dis 11:423-5. 2007
    ..Routine antimicrobial surveillance, coupled with molecular analysis of fluoroquinolone resistance, is crucial for revision of enteric fever therapeutics...
  77. pmc Effect of anaerobic growth on quinolone lethality with Escherichia coli
    Muhammad Malik
    Public Health Research Institute, 225 Warren Street, Newark, NJ 07103, USA
    Antimicrob Agents Chemother 51:28-34. 2007
    ..b>Nalidixic acid, norfloxacin, ciprofloxacin, and PD161144 were lethal for cultures growing aerobically, and the bacteriostatic ..
  78. pmc Spontaneous conversion to quinolone and fluoroquinolone resistance among wild-type Escherichia coli isolates in relation to phylogenetic background and virulence genotype
    James R Johnson
    Medical Service, VA Medical Center, Minneapolis, Minnesota 55417, USA
    Antimicrob Agents Chemother 49:4739-44. 2005
    ..20 Israeli cystitis isolates) were subjected to serial selective passaging to obtain derivatives resistant to nalidixic acid (NA) and ciprofloxacin (C)...
  79. ncbi Relation between induction of the mar operon and cyclohexane tolerance and reduction in fluoroquinolone susceptibility in Salmonella spp
    Isabel Escribano
    Servicio de Microbiologia, Hospital General Universitario de Elche, Camí de l Almazara s n, 03203 Elche, Alicante, Spain
    J Infect Chemother 12:177-80. 2006
    ....
  80. ncbi Increasing incidence of quinolone resistance in human non-typhoid Salmonella enterica isolates in Korea and mechanisms involved in quinolone resistance
    Sang Ho Choi
    Division of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Songpa Gu, Seoul, Republic of Korea
    J Antimicrob Chemother 56:1111-4. 2005
    We investigated the trends of nalidixic acid resistance in human non-typhoid Salmonella enterica in a Korean population, and examined some possible mechanisms involved in this resistance.
  81. doi Mutant prevention concentration of ciprofloxacin, enrofloxacin and nalidixic acid against Campylobacter jejuni
    Frédérique Pasquali
    Int J Antimicrob Agents 31:500-2. 2008
  82. ncbi Emergence of Vibrio cholerae O1 Biotype El Tor serotype Inaba in north India
    Neelam Taneja
    Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Jpn J Infect Dis 58:238-40. 2005
    ..All strains were resistant to nalidixic acid and trimethoprim, and showed moderate sensitivity to amoxycillin...
  83. ncbi Antimicrobial resistance patterns of Campylobacter from feedlot cattle*
    M D Englen
    USDA ARS, Bacterial Epidemiology and Antimicrobial Resistance Research Unit, Richard B Russell Agricultural Research Center, Athens, GA 30605 2720, USA
    J Appl Microbiol 99:285-91. 2005
    ..This study examined 448 Campylobacter strains isolated in 1999 and 2000 from US feedlot cattle for resistance to 12 antimicrobials...
  84. ncbi Nalidixic acid-susceptible, ciprofloxacin-resistant Neisseria gonorrhoeae strain in the UK
    P L Ragunathan
    J Antimicrob Chemother 56:437. 2005
  85. pmc Antimicrobial susceptibility patterns of Salmonella enterica serotype typhi in eastern Nepal
    Basudha Khanal
    Department of Microbiology, B P Koirala Institute of Health Sciences, Dharan, Nepal
    J Health Popul Nutr 25:82-7. 2007
    ..23%) showed reduced susceptibility (MIC >0.25 mg/L). Of 112 strains tested for nalidixic acid susceptibility, 86 (76%) were resistant...
  86. ncbi Characterization of high-level fluoroquinolone resistance in Escherichia coli O78:K80 isolated from turkeys
    E Giraud
    Station de Pathologie Aviaire et de Parasitologie, Institut National de la Recherche Agronomique, Centre de Recherche de Tours-Nouzilly, 37380 Monnaie, France
    J Antimicrob Chemother 47:341-3. 2001
    ..This indicated that at least two independent selection events may have occurred...
  87. ncbi In vitro fluoroquinolone-resistant mutants of Salmonella enterica serotype Enteritidis: analysis of mechanisms involved in resistance
    Sara M Soto
    Department of Functional Biology, University of Oviedo, Julian Claveria s n, 33006, Oviedo, Spain
    Int J Antimicrob Agents 22:537-40. 2003
    ..Two nalidixic acid-resistant (minimal inhibitory concentrations, MIC>256 mg/l), ciprofloxacin-susceptible (MIC 0...
  88. ncbi [Mutations of gyrA in ciprofloxacin resistant Escherichia coli strains]
    B Erac
    Dokuz Eylul Universitesi Tip Fakultesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dali, Izmir
    Mikrobiyol Bul 37:125-30. 2003
    ..The strain in which only Ser 83 Leu mutation was observed, showed high level nalidixic acid resistance (MIC > 256 mg/L)...
  89. ncbi Patterns of mutations in target genes in septicemia isolates of Escherichia coli and Klebsiella pneumoniae with resistance or reduced susceptibility to ciprofloxacin
    F Fendukly
    Clinical Microbiology MTC, Karolinska Institute and Hospital, Stockholm, Sweden
    APMIS 111:857-66. 2003
    ..Such isolates were also resistant to nalidixic acid. Isolates with borderline susceptibility to ciprofloxacin, on the other hand, behaved differently in the two ..
  90. ncbi Characterisation of Salmonella spp. mutants produced by exposure to various fluoroquinolones
    L Cebrian
    Seccion de Microbiologia, Hospital General Universitario de Elche, Universidad Miguel Hernandez, Camí de L Almazara, no 11, 03203 Elche Alicante, Spain
    Int J Antimicrob Agents 22:134-9. 2003
    We repeatedly exposed six Salmonella spp. strains of different serotypes (three susceptible to nalidixic acid and three resistant) to constant low concentrations of various fluoroquinolones with the aim of characterising the mutations ..
  91. ncbi Activity of faropenem and imipenem for ciprofloxacin-resistant bacteria
    Laura J V Piddock
    Antimicrobial Agents Research Group, Division of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, UK
    J Antimicrob Chemother 52:500-2. 2003
    ..To determine whether an association exists between ciprofloxacin and faropenem resistance in bacteria including multiply drug-resistant isolates...
  92. ncbi Determination of ciprofloxacin and nalidixic acid resistance in Campylobacter jejuni with a fluorogenic polymerase chain reaction assay
    Pawin Padungtod
    Population Medicine Center, A109 Veterinary Clinical Center, Michigan State University, East Lansing, Michigan 48824 1314, USA
    J Food Prot 66:319-23. 2003
    ..jejuni to ciprofloxacin and nalidixic acid. Sixty of the 84 C. jejuni isolates tested carried the Thr-86 mutation in the gyrA gene...
  93. ncbi Bacterial resistance to quinolone antibiotics in Poland
    Z Roliński
    Department of Pharmacology, Faculty of Veterinary Medicine, Agricultural University, Lublin, Poland
    J Vet Med B Infect Dis Vet Public Health 49:160-2. 2002
    ..The highest resistance of Escherichia coli was found to be against nalidixic acid (NA), 49.1% and flumequine (FLU), 38.2%. The sensitivity of the strains were: ciprofloxacin (CIP; 81...
  94. pmc In vivo selection of Campylobacter isolates with high levels of fluoroquinolone resistance associated with gyrA mutations and the function of the CmeABC efflux pump
    Naidan Luo
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, Ohio 44691, USA
    Antimicrob Agents Chemother 47:390-4. 2003
    ..These results reveal that Campylobacter is hypermutable in vivo under the selection pressure of FQ and highlight the need for the prudent use of FQ antibiotics...
  95. ncbi Resistance to quinolones in Campylobacter jejuni and Campylobacter coli from Danish broilers at farm level
    K Pedersen
    Danish Veterinary Institute, Department of Poultry, Fish and Fur Animals, Aarhus, Denmark
    J Appl Microbiol 94:111-9. 2003
    ..To investigate the prevalence of quinolone resistance among Campylobacter jejuni and Camp. coli isolates from Danish poultry at the farm level, as well as for the whole country...
  96. ncbi High prevalence of nalidixic acid resistant, ciprofloxacin susceptible phenotype among clinical isolates of Escherichia coli and other Enterobacteriaceae
    Joaquim Ruiz
    Departament de Microbiologia, IDIBAPS, Hospital Clinic, Facultat de Medicina, Universitat de Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Diagn Microbiol Infect Dis 42:257-61. 2002
    ..In this study the prevalence of the nalidixic acid resistant, ciprofloxacin susceptible phenotype among Enterobacteriaceae was analyzed...
  97. pmc Comparison of gyrA mutations, cyclohexane resistance, and the presence of class I integrons in Salmonella enterica from farm animals in England and Wales
    Ernesto Liebana
    Department of Bacterial Diseases, Veterinary Laboratories Agency Weybridge, Addlestone, Surrey KT15 3NB, UK
    J Clin Microbiol 40:1481-6. 2002
    ..The isolates were selected on the basis of resistance to nalidixic acid, representing a variety of the most prevalent serotypes in England and Wales...
  98. ncbi Single or double mutational alterations of gyrA associated with fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli
    R Bachoual
    , Centre Hospitalier Universitaire Henri Mondor, , France
    Microb Drug Resist 7:257-61. 2001
    ..Three of the five isolates of C. jejuni and the two isolates of C. coli had high-level resistance to nalidixic acid (MICs 128-256 microg/ml) and ciprofloxacin (MICs 32 microg/ml)...
  99. ncbi Quinolone resistance in potentially pathogenic and non-pathogenic Escherichia coli strains isolated from healthy ruminants
    J A Orden
    , Facultad de Veterinaria, Universidad Complutense, 28040 Madrid, Spain
    J Antimicrob Chemother 48:421-4. 2001
    ..In cattle, 5.9% of the strains were resistant to nalidixic acid and 4.9% were resistant to enrofloxacin and ciprofloxacin, whereas in sheep and goats only 0.5% and 1...
  100. pmc Epidemiology of nalidixic acid resistance and TEM-1- and TEM-52-mediated ampicillin resistance of Shigella sonnei isolates obtained in Korea between 1980 and 2000
    Young Sook Jeong
    Department of Microbiology, Kyungpook National University School of Medicine, Taegu 700 422, Korea
    Antimicrob Agents Chemother 47:3719-23. 2003
    The resistance to ampicillin and nalidixic acid in Shigella sonnei isolates obtained in Korea during the period 1998 to 2000 was characterized. Recently (J. Y. Oh, H. S. Yu, S. K. Kim, S. Y. Seol, D. T. Cho, and J. C. Lee, J. Clin...
  101. pmc Analysis of the gyrA gene of clinical Yersinia ruckeri isolates with reduced susceptibility to quinolones
    Alicia Gibello
    Departamento Sanidad Animal, Facultad de Veterinaria, Universidad Complutense, 28040 Madrid, Spain
    Appl Environ Microbiol 70:599-602. 2004
    ..formed a separate cluster with lower levels of susceptibility to all the quinolones tested, especially nalidixic acid (NA) and oxolinic acid (OA), compared with the isolates recovered between 1994 and 1998...

Research Grants10

  1. Microporidiosis in AIDS
    ELIZABETH DIDIER; Fiscal Year: 2004
    ..This model will provide a better understanding of how the immune response functions to control microsporidia that replicate in different sites within a host cell. ..
  2. Molecular Epidemiology of Community-Associated MRSA
    SANJAY SHUKLA; Fiscal Year: 2008
    ..We will determine the presence or absence of 40 different virulence factor genes in all 320 isolates listed in aim 2 and determine evolution of virulence factor genes in contemporary CA-MRSA. ..
  3. IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
    James Fox; Fiscal Year: 2009
    ..pylori pathogenesis and specifically evaluate the role of regulatory T cells in limiting H. pylori-induced gastric pathology. ..
  4. HUS Pathogenesis & clinical Outcome in an in vivo model
    James Fox; Fiscal Year: 2008
    ..We will use this model to study the pathogenesis of HUS and importantly to develop therapeutic regimens to prevent and treat EHEC disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  5. Helicobacter induced hepatitis and tumorigenesis
    James Fox; Fiscal Year: 2009
    ..A more complete understanding of the etiopathogenesis of hepatobiliary disease and hepatocellular carcinoma is likely to result in new strategies for treatment and prevention of these important human diseases. ..
  6. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    James Fox; Fiscal Year: 2006
    ....
  7. Microecology-murine gut-initiation & progression of IBD
    James Fox; Fiscal Year: 2005
    ..prior and subsequent to oral vaccination with Helicobacter spp. antigens and mucosal adjuvants, elucidate how these vaccine strategies influence microflora dynamics and impact gut cytokine responses. ..
  8. Pathogenesis of a novel Hantavirus from laboratory rats
    JOE SIMMONS; Fiscal Year: 2003
    ..abstract_text> ..
  9. Resistant E.coli in Humans and Poultry
    James Johnson; Fiscal Year: 2005
    ..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..