praziquantel

Summary

Summary: An anthelmintic used in most schistosome and many cestode infestations.

Top Publications

  1. ncbi Human schistosomiasis
    Bruno Gryseels
    Institute for Tropical Medicine Antwerp, Nationalestraat 155 B 2000, Antwerp, Belgium
    Lancet 368:1106-18. 2006
  2. ncbi Susceptibility or resistance of praziquantel in human schistosomiasis: a review
    Wei Wang
    Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, Wuxi City, Jiangsu Province 214064, People s Republic of China
    Parasitol Res 111:1871-7. 2012
  3. ncbi Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis
    Michael J Doenhoff
    School of Biology, University of Nottingham, University Park, Nottingham, UK
    Curr Opin Infect Dis 21:659-67. 2008
  4. ncbi Resistance of Schistosoma mansoni to praziquantel: is there a problem?
    Michael J Doenhoff
    School of Biological Sciences, University of Wales, Bangor, Deiniol Road, Bangor, Gwynedd LL57 2UW, Wales, UK
    Trans R Soc Trop Med Hyg 96:465-9. 2002
  5. pmc Performance and safety of praziquantel for treatment of intestinal schistosomiasis in infants and preschool children
    José C Sousa-Figueiredo
    Disease Control Strategy Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS Negl Trop Dis 6:e1864. 2012
  6. ncbi The global epidemiological situation of schistosomiasis and new approaches to control and research
    D Engels
    Parasitic Diseases and Vector Control, Communicable Diseases Control, Prevention and Eradication, World Health Organization, CH 1211 27, Geneva, Switzerland
    Acta Trop 82:139-46. 2002
  7. ncbi Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs
    M J Doenhoff
    School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Parasitology 136:1825-35. 2009
  8. pmc Utility of repeated praziquantel dosing in the treatment of schistosomiasis in high-risk communities in Africa: a systematic review
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    PLoS Negl Trop Dis 5:e1321. 2011
  9. pmc Influence of exposure history on the immunology and development of resistance to human Schistosomiasis mansoni
    Carla L Black
    Department of Microbiology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America
    PLoS Negl Trop Dis 4:e637. 2010
  10. pmc Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildren
    Narcis B Kabatereine
    Vector Control Division, Ministry of Health, Kampala, Uganda
    Bull World Health Organ 85:91-9. 2007

Detail Information

Publications264 found, 100 shown here

  1. ncbi Human schistosomiasis
    Bruno Gryseels
    Institute for Tropical Medicine Antwerp, Nationalestraat 155 B 2000, Antwerp, Belgium
    Lancet 368:1106-18. 2006
    ..The diagnostic standard is microscopic demonstration of eggs in the excreta. Praziquantel is the drug treatment of choice. Vaccines are not yet available...
  2. ncbi Susceptibility or resistance of praziquantel in human schistosomiasis: a review
    Wei Wang
    Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, Wuxi City, Jiangsu Province 214064, People s Republic of China
    Parasitol Res 111:1871-7. 2012
    Since praziquantel was developed in 1970s, it has replaced other antischistosomal drugs to become the only drug of choice for treatment of human schistosomiases, due to high efficacy, excellent tolerability, few and transient side effects,..
  3. ncbi Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis
    Michael J Doenhoff
    School of Biology, University of Nottingham, University Park, Nottingham, UK
    Curr Opin Infect Dis 21:659-67. 2008
    b>Praziquantel (PZQ) is the only drug being used to treat human schistosomiasis on a large scale...
  4. ncbi Resistance of Schistosoma mansoni to praziquantel: is there a problem?
    Michael J Doenhoff
    School of Biological Sciences, University of Wales, Bangor, Deiniol Road, Bangor, Gwynedd LL57 2UW, Wales, UK
    Trans R Soc Trop Med Hyg 96:465-9. 2002
    Evidence for resistance to praziquantel (PZQ) in Schistosoma mansoni has been sought in parasites taken from treated, but uncured human patients, and in a laboratory isolate of S...
  5. pmc Performance and safety of praziquantel for treatment of intestinal schistosomiasis in infants and preschool children
    José C Sousa-Figueiredo
    Disease Control Strategy Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS Negl Trop Dis 6:e1864. 2012
    ..that infants and preschool children are at significant risk of schistosomiasis and qualify for treatment with praziquantel (PZQ)...
  6. ncbi The global epidemiological situation of schistosomiasis and new approaches to control and research
    D Engels
    Parasitic Diseases and Vector Control, Communicable Diseases Control, Prevention and Eradication, World Health Organization, CH 1211 27, Geneva, Switzerland
    Acta Trop 82:139-46. 2002
    ..Related to this new vision, some research needs are pointed out...
  7. ncbi Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs
    M J Doenhoff
    School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Parasitology 136:1825-35. 2009
    Treatment with praziquantel (PZQ) has become virtually the sole basis of schistosomiasis control in sub-Saharan Africa and elsewhere, and the drug is reviewed here in the context of the increasing rate that it is being used for this ..
  8. pmc Utility of repeated praziquantel dosing in the treatment of schistosomiasis in high-risk communities in Africa: a systematic review
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    PLoS Negl Trop Dis 5:e1321. 2011
    ..In a systematic review of published studies, we examined evidence for incremental benefits from repeated praziquantel dosing, given 2 to 8 weeks after an initial dose, in Schistosoma-endemic areas of Africa.
  9. pmc Influence of exposure history on the immunology and development of resistance to human Schistosomiasis mansoni
    Carla L Black
    Department of Microbiology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America
    PLoS Negl Trop Dis 4:e637. 2010
    ..Previous studies suggest that humans can acquire immunity to reinfection with schistosomes, most probably due to immunologic mechanisms acquired after exposure to dying schistosome worms...
  10. pmc Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildren
    Narcis B Kabatereine
    Vector Control Division, Ministry of Health, Kampala, Uganda
    Bull World Health Organ 85:91-9. 2007
    ..We aimed to assess the health impact of a national control programme targeting schistosomiasis and intestinal nematodes in Uganda, which has provided population-based anthelmintic chemotherapy since 2003...
  11. ncbi Relative contribution of day-to-day and intra-specimen variation in faecal egg counts of Schistosoma mansoni before and after treatment with praziquantel
    J Utzinger
    Swiss Tropical Institute, Basel
    Parasitology 122:537-44. 2001
    ..3 times higher than day-to-day variation. After praziquantel administration, day-to-day variation was more important than before, since most infections were very light and ..
  12. ncbi Use of praziquantel for clinical treatment and morbidity control of schistosomiasis japonica in China: a review of 30 years' experience
    Ming Gang Chen
    National Institute of Parasitic Diseases, Chinese Centre for Disease Control and Prevention, Shanghai 200025, China
    Acta Trop 96:168-76. 2005
    ..The discovery of praziquantel in the 1970s has been a breakthrough for treatment of patients infected with schistosomes, including ..
  13. ncbi Schistosomiasis and pregnancy
    Jennifer F Friedman
    Center for International Health Research, Rhode Island Hospital, 55 Claverick Street, Providence, RI 02903, USA
    Trends Parasitol 23:159-64. 2007
    ..In addition, studies that address the safety of praziquantel during pregnancy could lead to further adoption of the recent informal recommendation by the World Health ..
  14. ncbi Use of circulating cathodic antigen strips for the diagnosis of urinary schistosomiasis
    N Midzi
    National Institute of Health Research, Harare, Zimbabwe
    Trans R Soc Trop Med Hyg 103:45-51. 2009
    ..The CCA strip was compared with egg detection before and six weeks after treatment with praziquantel. Pre-treatment prevalence (overall 40...
  15. pmc Increases in levels of schistosome-specific immunoglobulin E and CD23(+) B cells in a cohort of Kenyan children undergoing repeated treatment and reinfection with Schistosoma mansoni
    Carla L Black
    Center for Tropical and Emerging Global Diseases and Department of Microbiology, University of Georgia, Athens, Georgia 30602 3799, USA
    J Infect Dis 202:399-405. 2010
    ..whether children infected with Schistosoma mansoni develop protection-related immune responses after treatment with praziquantel and whether the development of these immune responses is accelerated by frequent treatment after reinfection.
  16. ncbi Sex- and stage-related sensitivity of Schistosoma mansoni to in vivo and in vitro praziquantel treatment
    Livia Pica-Mattoccia
    Institute of Cell Biology, CNR, 32 Via Ramarini, 00016 Monterotondo, Rome, Italy
    Int J Parasitol 34:527-33. 2004
    The efficacy of praziquantel against a Puerto Rican strain of Schistosoma mansoni was assessed using both in vivo and in vitro approach...
  17. pmc Schistosomiasis in African infants and preschool children: let them now be treated!
    J Russell Stothard
    Parasitology Department, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    Trends Parasitol 29:197-205. 2013
    ..Despite mounting evidence showing that treatment with praziquantel is safe, beneficial, and could be delivered within ongoing public health interventions, young children still do ..
  18. pmc Transcriptional analysis of Schistosoma mansoni treated with praziquantel in vitro
    Jarrett Hines-Kay
    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Mol Biochem Parasitol 186:87-94. 2012
    ..Control of the disease relies almost exclusively on praziquantel (PZQ) but this drug does not kill juvenile worms during the early stages of infection or prevent post-treatment ..
  19. ncbi PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution
    Rubiana M Mainardes
    Programa de Pós Graduação em Ciências Farmacêuticas, UNESP, Rod Araraquara Jaú Km 1, CEP 14802 902, Araraquara, SP, Brazil
    Int J Pharm 290:137-44. 2005
    b>Praziquantel has been shown to be highly effective against all known species of Schistosoma infecting humans. Spherical nanoparticulate drug carriers made of poly(D,L-lactide-co-glycolide) acid with controlled size were designed...
  20. pmc The impact of helminths on the response to immunization and on the incidence of infection and disease in childhood in Uganda: design of a randomized, double-blind, placebo-controlled, factorial trial of deworming interventions delivered in pregnancy and e
    Alison M Elliott
    Uganda Virus Research Institute, Entebbe, Uganda
    Clin Trials 4:42-57. 2007
    ..These effects might develop in utero, through exposure to maternal helminth infections, or through direct exposure in later life...
  21. pmc Intestinal schistosomiasis in mothers and young children in Uganda: investigation of field-applicable markers of bowel morbidity
    Martha Betson
    Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London, United Kingdom
    Am J Trop Med Hyg 83:1048-55. 2010
    ..0001) and mothers (n = 448, OR = 1.95, P = 0.004). Fecal occult blood appears to be useful for measuring morbidity associated with intestinal schistosomiasis and could be used in assessing the impact of control programs upon disease...
  22. pmc Closing the praziquantel treatment gap: new steps in epidemiological monitoring and control of schistosomiasis in African infants and preschool-aged children
    J Russell Stothard
    Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London, SW7 5BD, UK
    Parasitology 138:1593-606. 2011
    ..and Schistosoma mansoni, is being formally explored as infected children are not presently targeted to receive praziquantel (PZQ) within current preventive chemotherapy campaigns...
  23. ncbi Schistosomiasis
    Bruno Gryseels
    Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerpen, Belgium
    Infect Dis Clin North Am 26:383-97. 2012
    ..b>Praziquantel is the drug of choice, active against all species in a single or a few oral doses...
  24. ncbi Efficacy and side effects of praziquantel treatment in a highly endemic Schistosoma mansoni focus at Lake Albert, Uganda
    N B Kabatereine
    Vector Control Division, Ministry of Health, Kampala, Uganda
    Trans R Soc Trop Med Hyg 97:599-603. 2003
    The aim of the study was to assess the efficacy and side effects following single and repeated (6 weeks apart) praziquantel treatment (40 mg/kg) in a Schistosoma mansoni-endemic focus with long-standing transmission at Lake Albert in ..
  25. ncbi Schistosomiasis
    Allen G P Ross
    Medical University of the Americas, Charlestown, Nevis, West Indies
    N Engl J Med 346:1212-20. 2002
  26. pmc Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution
    J Utzinger
    Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Parasitology 136:1859-74. 2009
    ..guidelines issued by the World Health Organization, we estimate the projected annual treatment needs with praziquantel among the school-aged population and critically discuss these estimates...
  27. ncbi Increases in human T helper 2 cytokine responses to Schistosoma mansoni worm and worm-tegument antigens are induced by treatment with praziquantel
    Sarah Joseph
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Infect Dis 190:835-42. 2004
    ..production in response to soluble egg antigen (SEA), soluble worm antigen (SWA), or Teg after treatment with praziquantel (PZQ) in a cohort of 187 individuals living near Lake Albert, Uganda...
  28. ncbi Patterns of intestinal schistosomiasis among mothers and young children from Lake Albert, Uganda: water contact and social networks inferred from wearable global positioning system dataloggers
    Edmund Y W Seto
    School of Public Health, University of California, Berkeley, CA 94720, United States of America
    Geospat Health 7:1-13. 2012
    ..of a national control programme (NCP) in Uganda has led to routine treatment of intestinal schistosomiasis with praziquantel in the communities along Lake Albert...
  29. pmc Efficacy and safety of praziquantel in preschool-aged children in an area co-endemic for Schistosoma mansoni and S. haematobium
    Jean T Coulibaly
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 6:e1917. 2012
    ..but in high endemicity areas, preschool-aged children are also at risk, and hence might need treatment with praziquantel. Since a pediatric formulation (e.g...
  30. ncbi Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, tribendimidine, and praziquantel in patients with Opisthorchis viverrini: a randomised, exploratory, open-label, phase 2 trial
    Phonepasong Soukhathammavong
    National Institute of Public Health, Ministry of Health, Vientiane, Laos
    Lancet Infect Dis 11:110-8. 2011
    b>Praziquantel is the only drug available for treatment of Opisthorchis viverrini, although in-vivo studies point to activity of mefloquine, artesunate, and tribendimidine against this liver fluke...
  31. ncbi Efficacy and side effects of praziquantel treatment against Schistosoma haematobium infection among primary school children in Zimbabwe
    N Midzi
    National Institute of Health Research, Box CY 573, Causeway, Harare, Zimbabwe
    Trans R Soc Trop Med Hyg 102:759-66. 2008
    We examined the efficacy of praziquantel against Schistosoma haematobium among primary school children during a school-based deworming programme in the Burma Valley commercial farming area and the Nyamaropa rural areas in Zimbabwe, where ..
  32. pmc A diagnostic challenge for Schistosomiasis japonica in China: consequences on praziquantel-based morbidity control
    Yi biao Zhou
    Department of Epidemiology, School of Public Health, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China
    Parasit Vectors 4:194. 2011
    ..At present, selective chemotherapy with praziquantel is one of the main strategies in China's National Schistosomiasis Control Program, and thus diagnosis of ..
  33. ncbi Comparative efficacy of one versus two doses of praziquantel on cure rate of Schistosoma mansoni infection and re-infection in Mayuge District, Uganda
    Edridah M Tukahebwa
    Vector Control Division, Ministry of Health, Kampala, Uganda
    Trans R Soc Trop Med Hyg 107:397-404. 2013
    The current recommended control strategy for schistosomiasis is annual treatment using 40 mg/kg of praziquantel. However, praziquantel is only effective on adult worms and giving a second dose may increase its efficacy...
  34. ncbi Mixed infections with Opisthorchis viverrini and intestinal flukes in residents of Vientiane Municipality and Saravane Province in Laos
    J Y Chai
    Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110 799, Korea
    J Helminthol 79:283-9. 2005
    ..viverrini, heterophyid, or lecithodendriid eggs) were treated with a 20-30 mg kg(-1) single dose of praziquantel and purged...
  35. pmc Expression of matrix metalloproteinases and their inhibitors during the resorption of schistosome egg-induced fibrosis in praziquantel-treated mice
    Kameshwar P Singh
    Department of Immunology and Microbiology, Wayne State University School of Medicine, 540 E Canfield, Detroit, MI 48201, USA
    Immunology 111:343-52. 2004
    ..mansoni-infected and praziquantel-cured mice...
  36. ncbi Is there reduced susceptibility to praziquantel in Schistosoma japonicum? Evidence from China
    Wei Wang
    Jiangsu Institute of Parasitic Diseases, Meiyuan, Wuxi, Jiangsu Province, China
    Parasitology 137:1905-12. 2010
    b>Praziquantel is widely used for the treatment of human schistosomiasis. However, in recent years, there has been increasing concern about the resistance of Schistosoma species to praziquantel...
  37. ncbi The epidemiology and control of urinary schistosomiasis and soil-transmitted helminthiasis in schoolchildren on Unguja Island, Zanzibar
    J Russell Stothard
    Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London SW7 5BD, UK
    Trans R Soc Trop Med Hyg 103:1031-44. 2009
    ..around 140,000 school-aged children on Unguja Island, Zanzibar were treated annually with a combination of praziquantel and albendazole...
  38. pmc Effects of deworming during pregnancy on maternal and perinatal outcomes in Entebbe, Uganda: a randomized controlled trial
    J Ndibazza
    Medical Research Council Uganda Virus Research Institute Uganda Research Unit on AIDS, Entebbe, Uganda
    Clin Infect Dis 50:531-40. 2010
    ..Deworming during pregnancy has therefore been strongly advocated, but its benefits have not been rigorously evaluated...
  39. pmc Immunoglobulin E (IgE) responses to paramyosin predict resistance to reinfection with Schistosoma japonicum and are attenuated by IgG4
    Mario Jiz
    Center for International Health Research, Rhode Island Hospital, 55 Claverick Street, Providence, RI 02901, USA
    Infect Immun 77:2051-8. 2009
    ..Sera were collected from infected individuals 1 month posttreatment with praziquantel, and antibody responses were measured using a bead-based multiplex platform...
  40. ncbi Praziquantel treatment of individuals exposed to Schistosoma haematobium enhances serological recognition of defined parasite antigens
    Francisca Mutapi
    Institute for Immunology and Infection Research, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    J Infect Dis 192:1108-18. 2005
    ..This study aimed to identify and compare proteins recognized by serum samples from schistosome-exposed individuals before and after curative praziquantel treatment.
  41. pmc Towards an understanding of the mechanism of action of praziquantel
    Anthony D Aragon
    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Mol Biochem Parasitol 164:57-65. 2009
    Although praziquantel (PZQ) has been used to treat schistosomiasis for over 20 years its mechanism of action remains unknown...
  42. ncbi Drugs for the control of parasitic diseases: current status and development in schistosomiasis
    Alan Fenwick
    Schistosomiasis Control Initiative, St Mary s Campus, Imperial College, Norfolk Place, London W2 1PG, UK
    Trends Parasitol 19:509-15. 2003
  43. ncbi Efficacy of praziquantel against Schistosoma haematobium infection in children
    Louis Albert Tchuem Tchuenté
    Laboratory of General Biology, Faculty of Sciences, University of Yaounde, Yaounde, Cameroon
    Am J Trop Med Hyg 71:778-82. 2004
    A study was performed to determine the efficacy of praziquantel (PZQ) against Schistosoma haematobium. Children (n = 592) infected with S...
  44. ncbi Albendazole, mebendazole and praziquantel. Review of non-clinical toxicity and pharmacokinetics
    A D Dayan
    Parasitic Diseases and Vector Control PVC, Communicable Diseases Control, Prevention and Eradication CPE, World Health Organization, CH 1211 Geneva 27, Switzerland
    Acta Trop 86:141-59. 2003
    The pharmacokinetics and toxicity of albendazole, mebendazole and praziquantel are extensively reviewed, drawing on original published work and reviews in the open scientific literature and on assessments by international agencies and ..
  45. pmc Observed reductions in Schistosoma mansoni transmission from large-scale administration of praziquantel in Uganda: a mathematical modelling study
    Michael D French
    Schistosomiasis Control Initiative, Imperial College London, London, United Kingdom
    PLoS Negl Trop Dis 4:e897. 2010
    ..reductions in the rate of Schistosoma mansoni reinfection following annual mass drug administration (MDA) with praziquantel in Uganda over four years (2003-2006)...
  46. ncbi Efficacy of praziquantel syrup versus crushed praziquantel tablets in the treatment of intestinal schistosomiasis in Ugandan preschool children, with observation on compliance and safety
    A M D Navaratnam
    Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, UK
    Trans R Soc Trop Med Hyg 106:400-7. 2012
    ..5 years) have so far been overlooked by mass treatment campaigns targeting schistosomiasis, even though praziquantel (PZQ) has been shown to be well tolerated and effective within this age group...
  47. ncbi Sequential analysis of helminth egg output in human stool samples following albendazole and praziquantel administration
    Alexandra U Scherrer
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Acta Trop 109:226-31. 2009
    ..However, the optimal time points post-treatment for assessing the efficacy of praziquantel against Schistosoma mansoni and albendazole against hookworm infections are not known...
  48. pmc Circulating CD23+ B cell subset correlates with the development of resistance to Schistosoma mansoni reinfection in occupationally exposed adults who have undergone multiple treatments
    Pauline N M Mwinzi
    Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya
    J Infect Dis 199:272-9. 2009
    ..and their expression of the low-affinity IgE receptor (CD23) in a unique cohort of men occupationally exposed to Schistosoma mansoni and longitudinally followed up through multiple treatments with praziquantel, cures, and reinfections.
  49. pmc Effect of control strategies on prevalence, incidence and re-infection of clonorchiasis in endemic areas of China
    Min Ho Choi
    Department of Parasitology and Tropical Medicine and Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul, Korea
    PLoS Negl Trop Dis 4:e601. 2010
    ..A pilot clonorchiasis control project was implemented to evaluate the efficacies of various chemotherapy strategies on prevalence, incidence and re-infection in Heilongjiang Province, China...
  50. ncbi Improving control of African schistosomiasis: towards effective use of rapid diagnostic tests within an appropriate disease surveillance model
    J Russell Stothard
    Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK
    Trans R Soc Trop Med Hyg 103:325-32. 2009
    Contemporary control of schistosomiasis is typically reliant upon large-scale administration of praziquantel (PZQ) to school age children...
  51. pmc Two-year impact of single praziquantel treatment on infection in the national control programme on schistosomiasis in Burkina Faso
    Seydou Toure
    Programme National de Lutte contre la Schistosomiase et les Vers Intestinaux, Ministere de la Sante, Ouagadougou, Burkina Faso
    Bull World Health Organ 86:780-7, A. 2008
    To evaluate the impact on schistosomiasis of biennial treatment with praziquantel (PZQ) among school-age children in Burkina Faso, the first country that achieved full national coverage with treatment of more than 90% of the school-age ..
  52. ncbi Effect of combined treatment with praziquantel and artemether on Schistosoma japonicum and Schistosoma mansoni in experimentally infected animals
    J Utzinger
    Swiss Tropical Institute, P O Box, CH 4002, Basel, Switzerland
    Acta Trop 80:9-18. 2001
    b>Praziquantel and artemether are safe and efficacious antischistosomal drugs that act against different developmental stages of the parasite: praziquantel against adult worms and artemether against schistosomula...
  53. pmc Schistosoma mansoni population structure and persistence after praziquantel treatment in two villages of Bahia, Brazil
    Ronald E Blanton
    Case Western Reserve University, Centre for Global Health and Diseases, Wolstein Research Building, 2301 Cornell Road, Cleveland, OH 44106, USA
    Int J Parasitol 41:1093-9. 2011
    b>Praziquantel has been used to treat schistosome infections since 1979 and currently is the only chemotherapeutic agent in production for this purpose, raising concerns about the potential for the emergence of drug resistance...
  54. pmc Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring: results of a randomised, placebo-controlled trial
    Robert Tweyongyere
    Faculty of Veterinary Medicine, Makerere University, Kampala, Uganda
    BMC Infect Dis 11:234. 2011
    ..b>Praziquantel treatment during pregnancy boosts maternal immune responses to schistosome antigens and reduces worm burden...
  55. ncbi Schistosoma mansoni: a method for inducing resistance to praziquantel using infected Biomphalaria glabrata snails
    Flávia F B Couto
    Instituto de Pesquisas René Rachou, FIOCRUZ, Belo Horizonte, MG, Brasil
    Mem Inst Oswaldo Cruz 106:153-7. 2011
    ..We developed a new method for inducing resistance to praziquantel (PZQ) using successive drug treatments of Biomphalaria glabrata snails infected with S. mansoni. Infected B...
  56. pmc Urine heme dipsticks are useful in monitoring the impact of praziquantel treatment on Schistosoma haematobium in sentinel communities of Delta State, Nigeria
    Emmanuel Emukah
    The Carter Center, Owerri, Imo State, Nigeria
    Acta Trop 122:126-31. 2012
    ..To monitor the impact of annual mass drug administration (MDA) with Praziquantel for S...
  57. ncbi Schistosomiasis in infants and pre-school-aged children in sub-Saharan Africa: implication for control
    Uwem F Ekpo
    Department of Biological Sciences, University of Agriculture, PMB 2240, Abeokuta 110001, Nigeria
    Parasitology 139:835-41. 2012
    ..It is, therefore, necessary to review current policy of schistosomiasis control programmes in sub-Saharan Africa to consider the treatment of infant and pre-school-aged children and the health education to mothers...
  58. pmc Schistosoma haematobium infection levels determine the effect of praziquantel treatment on anti-schistosome and anti-mite antibodies
    N Rujeni
    Institute of Immunology and Infection Research, Centre for Infectious Diseases, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, Edinburgh, UK
    Parasite Immunol 34:330-40. 2012
    ..Thus, the study shows that the level of schistosome endemicity affects the host responses to schistosome and mite antigens following anti-helminthic treatment...
  59. pmc Schistosoma haematobium infections among schoolchildren in central Sudan one year after treatment with praziquantel
    Abedaziz M Ahmed
    Schistosomiasis Research Laboratory, Faculty of Science, University of Khartoum, Khartoum, Sudan
    Parasit Vectors 5:108. 2012
    Chemotherapy with praziquantel (PZQ) is the mainstay of schistosomiasis control. However, there are recent concerns about tolerance or resistance to PZQ, so that monitoring its efficacy in different settings is required.
  60. ncbi High level of Schistosoma mansoni infection in pre-school children in Sierra Leone highlights the need in targeting this age group for praziquantel treatment
    Mary H Hodges
    Helen Keller International, Freetown, Sierra Leone
    Acta Trop 124:120-5. 2012
    ..The national control program currently does not target this group of children for schistosomiasis, while mass drug administration (MDA) has been performed six monthly for STHs in children 12-59 months of age since 2006...
  61. pmc Use of fecal occult blood tests as epidemiologic indicators of morbidity associated with intestinal schistosomiasis during preventive chemotherapy in young children
    Martha Betson
    Disease Control Strategy Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    Am J Trop Med Hyg 87:694-700. 2012
    ..We therefore propose that FOB is useful for assessing dynamics of intestinal morbidity in young children at the community level and monitoring changes in morbidity after mass chemotherapy...
  62. pmc Transcriptional responses of in vivo praziquantel exposure in schistosomes identifies a functional role for calcium signalling pathway member CamKII
    Hong You
    Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS Pathog 9:e1003254. 2013
    Treatment for clinical schistosomiasis has relied centrally on the broad spectrum anthelmintic praziquantel; however, there is limited information on its mode of action or the molecular response of the parasite...
  63. ncbi Praziquantel reverses pulmonary hypertension and vascular remodeling in murine schistosomiasis
    Alexi Crosby
    Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge, United Kingdom
    Am J Respir Crit Care Med 184:467-73. 2011
    Schistosomiasis is the most common worldwide cause of pulmonary arterial hypertension. The anti-schistosome drug praziquantel has been shown to reverse the liver fibrosis associated with Schistosoma mansoni in mice.
  64. pmc Schistosome infection intensity is inversely related to auto-reactive antibody levels
    Francisca Mutapi
    Ashworth Laboratories, School of Biological Sciences, Institute for Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 6:e19149. 2011
    ..All participants were offered treatment with the anti-helminthic drug praziquantel and 102 treated schoolchildren (5-16 years) were followed up 6 months post-antihelminthic treatment...
  65. pmc New insight into the antifibrotic effects of praziquantel on mice in infection with Schistosoma japonicum
    Yue Jin Liang
    Department of Pathogen Biology, Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China
    PLoS ONE 6:e20247. 2011
    ..For this reason, new strategies and prospective drugs, which exert antifibrotic effects, are urgently required...
  66. pmc Resolution of praziquantel
    Michael Woelfle
    School of Chemistry, The University of Sydney, Sydney, New South Wales, Australia
    PLoS Negl Trop Dis 5:e1260. 2011
    b>Praziquantel remains the drug of choice for the worldwide treatment and control of schistosomiasis. The drug is synthesized and administered as a racemate...
  67. pmc Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis
    Rong Liu
    Department of Medical Parasitology, School of Basic Medical Science, Wuhan University, Wuhan 430071, People s Republic of China
    Parasit Vectors 4:201. 2011
    b>Praziquantel has been used as first-line drug for chemotherapy of schistosomiasis since 1984. Besides praziquantel, artemether and artesunate have also been used for the control of this infectious disease since late 1990s...
  68. ncbi Schistosoma haematobium infection and morbidity before and after large-scale administration of praziquantel in Burkina Faso
    Artemis Koukounari
    Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Imperial College London, London, W2 1PG, United Kingdom
    J Infect Dis 196:659-69. 2007
    ..In sub-Saharan Africa, 112 million people are infected with Schistosoma haematobium, with the most intense infections in children 5-15 years old...
  69. pmc Genetic consequences of mass human chemotherapy for Schistosoma mansoni: population structure pre- and post-praziquantel treatment in Tanzania
    Alice J Norton
    Department of Infectious Disease Epidemiology, Imperial College, Faculty of Medicine, London, United Kingdom
    Am J Trop Med Hyg 83:951-7. 2010
    ..Such unique results illustrate the importance of genetic monitoring and examination of long lived multi-cellular parasites such as these under novel or increased chemotherapeutic selective pressures...
  70. ncbi Serological analysis of the outcome of treatment of Schistosoma mansoni infections with praziquantel
    J Bligh
    Department of Clinical Parasitology, Hospital for Tropical Diseases, Mortimer Market Centre, London, UK
    Ann Trop Med Parasitol 104:511-20. 2010
    A serological assay was developed to assess the outcome of the treatment of intestinal schistosomiasis with praziquantel, in patients with Schistosoma mansoni infection. Each of 33 patients (seven found to be excreting S...
  71. ncbi Regression of hepatosplenomegaly in Kenyan school-aged children after praziquantel treatment and three years of greatly reduced exposure to Schistosoma mansoni
    Birgitte J Vennervald
    Danish Bilharziasis Laboratory, Charlottenlund, Denmark
    Trans R Soc Trop Med Hyg 99:150-60. 2005
    ..These results demonstrate that praziquantel treatment reduces hepatosplenomegaly in the absence of exposure to S...
  72. ncbi Schistosoma japonicum: a PCR assay for the early detection and evaluation of treatment in a rabbit model
    Chao Ming Xia
    Department of Parasitology, Medical College of Soochow University, Jiangsu Province, PR China
    Exp Parasitol 121:175-9. 2009
    ..These data demonstrated that the PCR assay established provides a potential tool for the early diagnosis and therapy evaluation for S. japonicum infection in humans...
  73. ncbi Formulation, characterization and pharmacokinetics of praziquantel-loaded hydrogenated castor oil solid lipid nanoparticles
    ShuYu Xie
    Department of Preventive Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, 2 Yuanmingyuan Road West, Beijing 100193, PR China
    Nanomedicine (Lond) 5:693-701. 2010
    The purpose of this study was to formulate praziquantel (PZQ)-loaded hydrogenated castor oil (HCO) solid lipid nanoparticles (SLN) to enhance the bioavailability and prolong the systemic circulation of the drug.
  74. pmc Collection of Clonorchis sinensis adult worms from infected humans after praziquantel treatment
    Chenghua Shen
    Department of Parasitology and Tropical Medicine and Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul 110 799, Korea
    Korean J Parasitol 45:149-52. 2007
    ..Eight egg positive residents voluntarily joined a process of collection of the passed worms after praziquantel treatment...
  75. ncbi Albendazole plus praziquantel versus albendazole alone as a pre-operative treatment in intra-abdominal hydatisosis caused by Echinococcus granulosus
    F Cobo
    General Surgery Department, Virgen del Camino Hospital, Pamplona, Spain
    Trop Med Int Health 3:462-6. 1998
    To compare the effects of a combined medication of albendazole (10 mg/kg/day) plus praziquantel (25 mg/kg/day) to those of albendazole alone at different doses (10 and 20 mg/kg/day).
  76. ncbi Are Ca2+ channels targets of praziquantel action?
    Robert M Greenberg
    Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543, USA
    Int J Parasitol 35:1-9. 2005
    b>Praziquantel is the current drug of choice for the control of schistosomiasis. It is highly effective against all species of schistosomes and shows minimal adverse effects...
  77. ncbi Reinfection with Schistosoma haematobium following school-based chemotherapy with praziquantel in four highly endemic villages in Côte d'Ivoire
    E K N'Goran
    UFR Biosciences, Universite de Cocody, Abidjan, Cote d Ivoire
    Trop Med Int Health 6:817-25. 2001
    We present the comparative evaluation of school-based chemotherapy with praziquantel on Schistosoma haematobium reinfection patterns, 6, 12, 18 and 24 months after systematic treatment of schoolchildren in four villages of south-central C..
  78. ncbi Schistosome calcium channel beta subunits. Unusual modulatory effects and potential role in the action of the antischistosomal drug praziquantel
    A B Kohn
    Whitney Laboratory, University of Florida, St. Augustine, Florida 32080, USA
    J Biol Chem 276:36873-6. 2001
    ..The current drug of choice against schistosomiasis is praziquantel (PZQ), which has minimal side effects and is potent against all schistosome species...
  79. ncbi Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, and praziquantel against Schistosoma haematobium: randomized, exploratory open-label trial
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
    Clin Infect Dis 50:1205-13. 2010
    Morbidity control of schistosomiasis relies on a single drug, praziquantel. The antimalarial drug mefloquine possesses interesting antischistosomal properties, yet no clinical studies have been performed.
  80. pmc Anthelminthic treatment during pregnancy is associated with increased risk of infantile eczema: randomised-controlled trial results
    Harriet Mpairwe
    MRC UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
    Pediatr Allergy Immunol 22:305-12. 2011
    ..Allergy is commoner in developed than in developing countries. Chronic worm infections show inverse associations with allergy, and prenatal exposures may be critical to allergy risk...
  81. ncbi Field-based evaluation of a reagent strip test for diagnosis of Schistosoma mansoni by detecting circulating cathodic antigen in urine before and after chemotherapy
    Mengistu Legesse
    Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P O Box 1176, Addis Ababa, Ethiopia
    Trans R Soc Trop Med Hyg 101:668-73. 2007
    ..Diagnosis of S. mansoni infection in urine using reagent strips would provide information on the prevalence of the disease, although further study is needed to improve its sensitivity and specificity...
  82. pmc High prevalence of liver and intestinal fluke infections among residents of Savannakhet Province in Laos
    Jong Yil Chai
    Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110 799, Korea
    Korean J Parasitol 45:213-8. 2007
    ..To obtain adult flukes, 38 small trematode egg positive cases were treated with a 20-30 mg/kg single dose of praziquantel and purged...
  83. pmc Prevalence of the intestinal flukes Haplorchis taichui and H. yokogawai in a mountainous area of Phongsaly Province, Lao PDR
    Jong Yil Chai
    Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Seoul, Korea
    Korean J Parasitol 48:339-42. 2010
    ..years) who consumed raw freshwater fish and had gastrointestinal troubles were treated with a single dose of praziquantel (40 mg/kg) and pyrantel pamoate (10 mg/kg) and purged with magnesium sulfate to recover any worm parasites...
  84. pmc Schistosoma haematobium treatment in 1-5 year old children: safety and efficacy of the antihelminthic drug praziquantel
    Francisca Mutapi
    Ashworth Laboratories, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Negl Trop Dis 5:e1143. 2011
    ..is currently controlled by treatment of schistosome infected people with the antihelminthic drug praziquantel (PZQ)...
  85. ncbi Schistosoma mekongi in Cambodia and Lao People's Democratic Republic
    Sinuon Muth
    National Centre for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
    Adv Parasitol 72:179-203. 2010
    ..Control programmes built around mass drug administration, with praziquantel, and combined with information and education campaigns, were carried out...
  86. ncbi Efficacy and side-effects of two praziquantel treatments against Schistosoma haematobium infection, among schoolchildren from Côte d'Ivoire
    E K N'Goran
    Unité de Formation et de Recherche Biosciences, Universite de Cocody, 22 BP 770, Abidjan 22, Cote d Ivoire
    Ann Trop Med Parasitol 97:37-51. 2003
    b>Praziquantel is the current drug of choice for the control of schistosome-attributable morbidity and is likely to remain so for several years...
  87. ncbi Praziquantel for the treatment of schistosomiasis: its use for control in areas with endemic disease and prospects for drug resistance
    Michael J Doenhoff
    University of Wales Bangor, School of Biological Sciences, Bangor, Gwynedd LL576 2UW, UK
    Expert Rev Anti Infect Ther 4:199-210. 2006
    b>Praziquantel became available for the treatment of schistosomiasis and other trematode-inflicted diseases in the 1970s. It was revolutionary because it could be administered orally and had very few unwanted side effects...
  88. ncbi Are poor responses to praziquantel for the treatment of Schistosoma mansoni infections in Senegal due to resistance? An overview of the evidence
    B Gryseels
    Institute of Tropical Medicine, Antwerp, Belgium
    Trop Med Int Health 6:864-73. 2001
    ..paper summarizes and concludes in-depth field investigations on suspected resistance of Schistosoma mansoni to praziquantel in northern Senegal. Praziquantel at 40 mg/kg usually cures 70-90% of S. mansoni infections...
  89. ncbi Progress towards countrywide control of schistosomiasis and soil-transmitted helminthiasis in Uganda
    Narcis B Kabatereine
    Vector Control Division, Ministry of Health, Kampala, Uganda
    Trans R Soc Trop Med Hyg 100:208-15. 2006
    ..As a way forward, it is suggested that the Ministry of Health should integrate deworming into the existing health infrastructure so that every time a child is reached for any health service, the child is also de-wormed...
  90. ncbi Efficacy of artesunate and praziquantel in Schistosoma haematobium infected schoolchildren
    D De Clercq
    Région Médicale de Saint Louis, Programme ESPOIR, Saint Louis, Senegal
    Acta Trop 82:61-6. 2002
    b>Praziquantel is the current mainstay for morbidity control of schistosomiasis. Artemisinin and its derivatives, widely used for the treatment of malaria, also display antischistosomal properties...
  91. ncbi The in vitro effect of mefloquine and praziquantel against juvenile and adult Schistosoma japonicum
    Shu Hua Xiao
    National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Key Laboratory of Parasite and Vector Biology, MOH, WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai, 200025, People s Republic of China
    Parasitol Res 106:237-46. 2009
    ..in vitro effect of mefloquine against adult and juvenile Schistosoma japonicum and to compare its efficacy with praziquantel. Three-hour-old schistosomula were prepared by penetrating the mouse skin with schistosome cercariae, while ..
  92. ncbi Determination of ED50 values for praziquantel in praziquantel-resistant and -susceptible Schistosoma mansoni isolates
    Donato Cioli
    Institute of Cell Biology, 32 Via Ramarini, 00016 Monterotondo, Rome, Italy
    Int J Parasitol 34:979-87. 2004
    The dose of praziquantel required to kill 50% of adult worms in vivo (i.e. the ED50) was estimated for nine different isolates of Schistosoma mansoni in infected mice...
  93. ncbi Efficacy and side effects of praziquantel against Schistosoma mansoni in a community of western Côte d'Ivoire
    Giovanna Raso
    Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Trans R Soc Trop Med Hyg 98:18-27. 2004
    b>Praziquantel is efficacious against the adult stages of all human schistosome parasites, and has become the drug of choice for morbidity control of schistosomiasis...
  94. pmc Evaluation of efficacy of school-based anthelmintic treatments against anaemia in children in the United Republic of Tanzania
    H L Guyatt
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, England
    Bull World Health Organ 79:695-703. 2001
    ..To determine the impact of deworming on anaemia as part of a large-scale school-based anthelmintic treatment programme in the Tanga Region of the United Republic of Tanzania...
  95. ncbi Associations between specific antibody responses and resistance to reinfection in a Senegalese population recently exposed to Schistosoma mansoni
    Kim Vereecken
    Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium
    Trop Med Int Health 12:431-44. 2007
    ..Resistance to reinfection and production of IgA-SWA was associated with adulthood independently of exposure patterns, suggesting that susceptibility to S. mansoni and the development of protective immune responses is age-dependent...
  96. ncbi Evaluation of the efficacy of emodepside plus praziquantel topical solution against ascarid infections (Toxocara cati or Toxascaris leonina) in cats
    C R Reinemeyer
    East Tennessee Clinical Research, Knoxville, Tennessee, USA
    Parasitol Res 97:S41-50. 2005
    ..in the United States and Europe to evaluate the efficacy of a topical solution of emodepside (3 mg/kg)+praziquantel (12 mg/kg) (Profender, Bayer AG, Leverkusen, Germany) against infection with various stages of the ascarid ..
  97. ncbi Effect of praziquantel on the immature stages of Schistosoma haematobium
    Sanaa Botros
    Department of Pharmacology, Theodor Bilharz Research Institute, Giza 12411, Egypt
    Int J Parasitol 35:1453-7. 2005
    Schistosoma mansoni is known to be refractory to praziquantel treatment in the pre-patent period of infection. Since Schistosoma haematobium has a much longer pre-patent period (10-12 weeks vs...
  98. ncbi Activity of praziquantel on in vitro transformed Schistosoma mansoni sporocysts
    A C A Mattos
    Laboratorio de Esquistossomose, Centro de Pesquisas Rene Rachou Fiocruz, Av Augusto de Lima 1715, 31190 002 Belo Horizonte, MG, Brazil
    Mem Inst Oswaldo Cruz 101:283-7. 2006
    b>Praziquantel (PZQ) is effective against all the evolutive phases of Schistosoma mansoni. Infected Biomphalaria glabrata snails have their cercarial shedding interrupted when exposed to PZQ...
  99. pmc Triple co-administration of ivermectin, albendazole and praziquantel in zanzibar: a safety study
    Khalfan A Mohammed
    Programme for Lymphatic Filariasis, Schistosomiasis and Soil Transmitted Helminthiasis, Ministry of Health and Social Welfare, Zanzibar, United Republic of Tanzania
    PLoS Negl Trop Dis 2:e171. 2008
    ....
  100. ncbi Artesunate plus sulfadoxine/pyrimethamine versus praziquantel in the treatment of Schistosoma mansoni in eastern Sudan
    Ayoub A Mohamed
    New Halfa Teaching Hospital, New Halfa, Sudan
    Trans R Soc Trop Med Hyg 103:1062-4. 2009
    ..days+25 mg sulfadoxine on Day 0) in the treatment of Schistosoma mansoni infections were compared with those of praziquantel (PZQ) (40 mg/kg) among infected schoolchildren (46 in each study arm) in eastern Sudan...
  101. ncbi Efficacy of a single milbemycin oxime administration in combination with praziquantel against experimentally induced heartworm (Dirofilaria immitis) infection in cats
    Claudio Genchi
    Department of Animal Pathology, Universita degli Studi di Milano, Via Celoria 10, 20133 Milano, Italy
    Vet Parasitol 122:287-92. 2004
    The efficacy of a combination of milbemycin oxime and praziquantel in preventing the establishment of experimentally induced heartworm (Dirofilaria immitis) infection was investigated in a study involving 24 young domestic short-hair cats...

Research Grants62

  1. Experimental Molecular Vaccines for Schistosomiasis
    Afzal A Siddiqui; Fiscal Year: 2012
    ..7 million/year. In spite of advances in control via snail eradication and large-scale chemotherapy using praziquantel (a drug developed 30 years ago);this disease continues to spread to new geographic areas...
  2. Understanding the biology of schistosomes in response to praziquantel
    Charles Cunningham; Fiscal Year: 2013
    ..b>Praziquantel (PZQ) is the least expensive, easiest to use and most readily available of all current anti-schistosomal drugs...
  3. Evo-epidemiology of Scistosoma mansoni in children in Kenya
    ERIC SAMUEL LOKER; Fiscal Year: 2010
    ..Each child to be studied will be treated with praziquantel as part of the umbrella JICA project, and we will assess the impact of treatment on the genetic composition of ..
  4. Schistosomiasis Vaccine Development and Morbidity throughout the Life Course
    REMIGIO MEDINA OLVEDA; Fiscal Year: 2013
    ..FDA IND for the Sj97 vaccine, inform risk-benefit analysis with respect to targeting women for treatment with Praziquantel during pregnancy, and highlight mechanisms of dysregulated collagen metabolism in mediating poor pregnancy ..
  5. Exploring statins as a small molecule therapy for treatment of schistosomiasis
    Conor Caffrey; Fiscal Year: 2013
    ..Treatment and control of schistosomiasis relies on just one drug, praziquantel (PZQ). Apart from concerns over possible drug resistance, PZQ has a number of failings...
  6. Novel targets and drugs for the control of platyhelminth infections
    MARCOS GUSTAVO SALINAS; Fiscal Year: 2012
    ..Large-scale treatment of flatworm infections relies on a single drug available: praziquantel, and the emergence of drug resistance is an impending menace...
  7. Modeling Drug Induced Resistance in S. mansoni Endemic Areas
    Rodrigo Correa-Oliveira; Fiscal Year: 2013
    ..complement traditional epidemiology to provide a better understanding of disease transmission, the impact of praziquantel drug treatment over time and the adaptability of the schistosome parasite...
  8. Determinants of resistance in human schistosomiasis
    Daniel G Colley; Fiscal Year: 2013
    ..We and others have evidence that resistance to reinfection with schistosomes can develop after praziquantel treatment, especially when this involves multiple rounds of treatments and reinfections...
  9. PRODUCT DEVELOPMENT OF A MEMBRANE TETRASPANIN VACCINE AGAINST SCHISTOSOMIASIS
    CHARLES RUSSELL MIDDAUGH; Fiscal Year: 2011
    ..The current approach to schistosomiasis control relies on mass drug administration with praziquantel, but high rates of post-treatment re-infection, rebound morbidity, and concerns about drug resistance have led ..
  10. Assaying the Anthelmintic Potential of a Novel Flatworm-Specific GPCR Family
    Timothy A Day; Fiscal Year: 2013
    ..small portfolio of drugs shoulders the burden of control, relying almost completely on the antischistosomal praziquantel. It is now generally accepted that drug resistance is the inevitable consequence of an over-dependence on ..
  11. Efficient Linkage Mapping Methods for Schistosoma mansoni
    Philip T LoVerde; Fiscal Year: 2013
    ..Reduced cure rate following treatment with praziquantel (PZQ), the mainstay of Schistosomiasis control, has been reported from multiple foci and has a genetic basis;..
  12. S.japonicum and pregnancy outcomes: an RCT
    Jennifer F Friedman; Fiscal Year: 2012
    ..The proposed study is a randomized controlled trial of Praziquantel for women infected with S. japonicum in endemic villages in Leyte, The Philippines...
  13. Schistosome Vaccines
    Jonathan D Kurtis; Fiscal Year: 2013
    ..Although schistosomiasis is effectively treated with Praziquantel (PZQ), rapid reinfection with rebound morbidity precludes effective control based on chemotherapy alone and ..
  14. TLR Mediated Trophoblast Injury and Poor Pregnancy Outcomes in S. japonica
    Emily A McDonald; Fiscal Year: 2013
    ..Treatment with praziquantel (PZQ) is the standard of care for many of those suffering from schistosome infections, however pregnant women ..
  15. Pathogenesis, Carcinogenesis and Ecology of Opisthorchiasis in Thailand
    Banchob Sripa; Fiscal Year: 2013
    ..profiles of individuals whose liver (periportal) fibrosis do or does not resolve after medication with praziquantel to remove the parasite infection...
  16. Vaccines for human Schistosomiasis japonica
    Jonathan D Kurtis; Fiscal Year: 2011
    ..Although schistosomiasis is effectively treated with Praziquantel (PZQ), rapid reinfection with rebound morbidity precludes effective control based on chemotherapy alone and ..
  17. Developing comparative and functional genomic approaches to study Schistosoma
    Phillip A Newmark; Fiscal Year: 2013
    ..Currently only a single drug (praziquantel) is available to treat this disease, highlighting the importance of developing new techniques to study these ..
  18. Neurocysticercosis: Combined Treatment with Praziquantel and Albendazole
    Hector Hugo Garcia; Fiscal Year: 2012
    ..will perform a double-blind, randomized clinical trial to determine if a 10-days combined regime of regime of praziquantel (PZQ) and albendazole (ABZ) improves the parasiticidal efficacy of ABZ alone at the same dose and length of ..
  19. Understanding the biology of schistosomes in response to praziquantel
    Charles Cunningham; Fiscal Year: 2010
    ..An estimated 207 million people are infected, 97% of whom live on the African continent. Praziquantel (PZQ) is the least expensive, easiest to use and most readily available of all current anti-schistosomal drugs...
  20. Snail-Related Studies of Transmission and Control of Schistosomiasis in Kenya
    ERIC SAMUEL LOKER; Fiscal Year: 2013
    ..Control programs focus almost exclusively on treating people with the one widely available drug, praziquantel, yet drug-based control consistently fails to interrupt transmission because it ignores the central role of ..
  21. TGF-beta signaling in schistosomes
    Edward J Pearce; Fiscal Year: 2012
    ..This is important since we currently have broad access to only one drug, praziquantel, for the treatment of schistosomiasis and consequently the potential for the development of resistance to this ..
  22. Schistosome TRP ion channels as potential drug targets
    Robert M Greenberg; Fiscal Year: 2013
    ..The current drug of choice against schistosomiasis is praziquantel. Indeed, praziquantel is the only drug currently available in most parts of the world...
  23. Fibrosin: A Candidate Biomarker of Schistosomal Liver Fibrosis in Humans
    DAVID J WYLER; Fiscal Year: 2013
    ..Although schistosomiasis is effectively treated with praziquantel (PZQ), rapid reinfection with rebound morbidity and fibrosis precludes effective control based on chemotherapy ..
  24. THE EFFECT OF SCHISTOSOMIASIS ON SEVERE MALARIA IN A PRIMATE MODEL
    Thomas M Kariuki; Fiscal Year: 2011
    ..makes malaria worse, then administration of a single cheap dose of anti- helminthic drug such as Praziquantel could markedly affect malaria outcomes...
  25. Transformation of C. elegans with a novel schistosome calcium channel subunit
    Robert M Greenberg; Fiscal Year: 2010
    ..b>Praziquantel (PZQ) is the current drug of choice against schistosomiasis, but the mechanism by which PZQ acts remains poorly ..
  26. Adjuvant and Dose Optimization of Paramyosin based Vaccines for Schistosmiasis
    Jonathan D Kurtis; Fiscal Year: 2013
    ..Although schistosomiasis is effectively treated with Praziquantel (PZQ), rapid reinfection with rebound morbidity precludes effective control based on chemotherapy alone and ..
  27. An automated high throughput phenotypic screen for schistosomiasis drug discovery
    Rahul Singh; Fiscal Year: 2012
    ..Treatment relies on a single drug, praziquantel (PZQ)...
  28. Pathogenesis of Liver Fluke Induced Cancer in Thailand
    Paul Brindley; Fiscal Year: 2009
    ..In Northeast Thailand and Laos, despite widespread administration of the anti-worm drug praziquantel, the prevalence of O. viverrini approaches 70% in some endemic areas...
  29. Increasing the Antischistosomal Selectivity of Aryl Hydantoins
    Jonathan L Vennerstrom; Fiscal Year: 2013
    ..A new drug for schistosomiasis is urgently needed as praziquantel is currently the drug of last resort and the development of resistance cannot be ignored, particularly in view ..
  30. Design, Development and Biological Evaluation of Praziquantel (PZQ) Analogues: In
    Alfred Williams; Fiscal Year: 2013
    ..activity relationship SAR program aimed at the discovery and development of a new potent analog of the drug praziquantel (PZQ) for the treatment of schistosomiasis (bilharzia or 'snail fever')...
  31. Induction of Pathogenic Innate and Adaptive Immune Responses by Schistosome Helmi
    MARA SHAINHEIT; Fiscal Year: 2009
    ..Despite a highly effective drug treatment with praziquantel, re-infection with schistosomes is a common occurrence in the endemic regions of the world...
  32. SCHISTOSOME RECEPTOR SERINE/THRENONINE KINASE
    Edward Pearce; Fiscal Year: 1999
    ..Despite the availability of an excellent drug (praziquantel) and its widespread use, the incidence of schistosomiasis has not decreased...
  33. Synthesis and Biology of Bengazole Analogs
    Peter Wipf; Fiscal Year: 2003
    ..since resistance of nematodes to the anthelminthic drugs of general use such as benzimidazoles levamizole and praziquantel has emerged...
  34. SCHISTOSOME NUCLEAR PROTEIN FUNCTION AND REGULATION
    James Tracy; Fiscal Year: 2000
    ..There is no vaccine and praziquantel is the only broad-spectrum antischistosomal drug available...
  35. Schistosoma mansoni resistance to Praziquantel treatment
    DENNIS MINCHELLA; Fiscal Year: 2007
    ..The main control strategy involves mass-treating infected human populations with the drug Praziquantel. However, this methodology is problematic given that parasite resistance to Praziquantel has been reported from ..
  36. Trematocidal Synthetic Perioxides
    JONATHAN VENNERSTROM; Fiscal Year: 2009
    ..Importantly, new drugs for these diseases are urgently needed as praziquantel and triclabendazole are the only drugs available and the development of resistance cannot be ignored, ..
  37. MODULATION OF LIVER FLUKE-ASSOCIATED NEOPLASIA
    Nobuyuki Ito; Fiscal Year: 1990
    ..and suffering parasite exposure for different periods will be administered the drug praziquantel and the resultant effect on neoplastic lesion development assessed...
  38. HTS Inhibitors:Schistosoma Mansoni Peroxiredoxins(RMI)
    David Williams; Fiscal Year: 2005
    ..programs will treat tens of millions of people with the single anti-schistosomiasis drug in widespread use, praziquantel. There is already clinical and laboratory evidence for the existence of praziquantel resistance parasites and ..
  39. STRUCTURE AND FUNCTION OF SCHISTOSOME NEUROPEPTIDE F
    Timothy Day; Fiscal Year: 2009
    ..b>Praziquantel is presently the only drug available for the treatment of schistosomiasis in most parts of the world, but there ..
  40. Significance of Edema Around Calcified Brain Cysticerci
    Robert Gilman; Fiscal Year: 2004
    ..Intraparenchymal brain cysts may resolve by natural evolution or following antiparasitic therapy with either praziquantel or albendazole, leaving in most cases a calcified scar...
  41. SUPPRESSION OF IMMUNOPATHOLOGY IN SCHISTOSMIASIS BY ANTI
    S Phillips; Fiscal Year: 2001
    ..Ag-Dm will be used alone and in conjunction with anthelminthic cure by Praziquantel to simulate its projected use in human disease...
  42. Developmental Gene Regulation in Schistosoma mansoni
    David Williams; Fiscal Year: 2006
    ..Currently, drug treatment is based on a single agent, praziquantel, and there is evidence supporting the emergence of drug resistant parasites...
  43. RESISTANCE TO PRAZIQUANTEL--AN EMERGING PROBLEM
    James Bennett; Fiscal Year: 2000
    ..objective of this project is to develop a rapid, inexpensive and reliable assay to monitor the presence of praziquantel (PZQ) resistant schistosomes in humans...
  44. TOWARD A MOLECULARLY-DEFINED VACCINE FOR SCHISTOSOMIASIS
    Philip Loverde; Fiscal Year: 2009
    ..Safe and effective drugs such as praziquantel are available for the treatment of uncomplicated schistosomiasis. They provide interim control of disease...
  45. REMOTE SENSING AND GIS FOR SCHISTOSOMIASIS CONTROL
    Robert Spear; Fiscal Year: 2002
    ..Subsequently, efforts will be made to make the classification more precise by supplementing these data with ecological and landscape data and to evaluate alternative remotely sensed data for their ability to predict risk areas. ..
  46. POTENTIAL TARGETS FOR NEW ANTISCHISTOSOMAL AGENTS
    Robert Greenberg; Fiscal Year: 2006
    ..Chemotherapeutic agents are used to treat the disease and control its spread. Praziquantel (PZQ), the drug of choice, has minimal side effects and is effective against all schistosome species...
  47. Local Strategies for Schistosomiasis Control
    Robert Spear; Fiscal Year: 2006
    ....
  48. Function and pharmacology of schistosome multidrug resistance proteins
    Robert M Greenberg; Fiscal Year: 2010
    ..We will also examine the effects of praziquantel, the current antischistosomal of choice, on expression of SMDR2, and whether praziquantel-resistant isolates ..
  49. DETERMINANTS OF HEPATITIS C & E MORBIDITY IN EGYPT
    George Strickland; Fiscal Year: 2002
    ..abstract_text> ..
  50. GENETICS OF SEVERE HEPATIC FIBROSIS IN SCHISTOSOMIASIS
    RONALD BLANTON; Fiscal Year: 2001
    ..mansoni as tools for analyzing parasite heterogeneity. This proposal is in response to PA-96-067: Molecular Correlates of Pathogenesis in Parasitic Diseases. ..
  51. Behavioral factors and dietary change in WHTFSMP
    Alok Bhargava; Fiscal Year: 2003
    ..Overall, the results will facilitate the design of policies for improving health of especially minority women in the United States and will be useful for analyses of the Women's Health Initiative data. ..
  52. Novel Vaccine Candidates for Falciparum Malaria
    Jonathan Kurtis; Fiscal Year: 2004
    ..Subsequent experiments will evaluate the relationship between humoral and cellular immune recognition of these candidates and resistance to reinfection in the entire cohort of 143 volunteers. ..
  53. HOST IMMUNOMODULATION BY PARASITES
    Ramaswamy Kalyanasundaram; Fiscal Year: 2004
    ..Overall, the findings from these studies we believe might help improve per-cutaneous vaccination against this disease using defined candidate vaccine antigens against schistosomiasis. ..
  54. Host Genetics and Symptomatic Dengue Infection
    RONALD BLANTON; Fiscal Year: 2004
    ..The results of this study may help predict populations at risk, may influence vaccine design or may aid in understanding and managing other viral hemorrhagic fevers. ..
  55. DETERMINANTS OF HEPATITIS C & E MORBIDITY IN EGYPT
    George Strickland; Fiscal Year: 2004
    ..abstract_text> ..
  56. URINARY SCHISTOSOMIASIS: INFECTION AND DISEASE
    Charles King; Fiscal Year: 2004
    ..This information, combined with epidemiological modeling of control strategies, will allow accelerated synthesis of the next generation of control programs. ..
  57. HUMAN POPULATION GROWTH IMPACT ON S. HAEMATOBIUM
    Charles King; Fiscal Year: 2005
    ....
  58. Puberty, Immunity and Malnutrition in S. Japonicum
    Jonathan Kurtis; Fiscal Year: 2005
    ..japonicum including the identification of appropriate antigens, protective isotype and cytokine responses and the modulating effects of host pubertal and nutritional development on these responses. ..
  59. Vaccine induced resistance against E. granulosus in dogs
    Wenbao Zhang; Fiscal Year: 2007
    ..granulosus infection by vaccination with the recombinant proteins. We will test humoral and cellular responses generated during vaccination to determine possible correlations of the immune parameters with protection. ..
  60. MULTIVALENT VACCINE FOR LYMPHATIC FILARIASIS
    Ramaswamy Kalyanasundaram; Fiscal Year: 2010
    ..The proposed studies are based on solid preliminary data and are hypotheses driven. Results from these studies, we believe will advance our knowledge towards developing a defined vaccine against lymphatic filariasis in the human. ..