atracurium

Summary

Summary: A non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for elimination provide clinical advantage over alternate non-depolarizing neuromuscular blocking agents.

Top Publications

  1. ncbi Effects of atracurium on intraocular pressure, eye position, and blood pressure in eucapnic and hypocapnic isoflurane-anesthetized dogs
    Rose M McMurphy
    Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    Am J Vet Res 65:179-82. 2004
  2. ncbi Hemodynamic effects of atracurium and cisatracurium and the use of diphenhydramine and cimetidine
    Claudia Maria Nogueira Correa
    Instituto Fernandes Figueira, FIOCRUZ
    Rev Bras Anestesiol 60:52-63. 2010
  3. ncbi Comparison of neuromuscular effects, efficacy and safety of rocuronium and atracurium in ambulatory anaesthesia
    D G Whalley
    Department of General Anesthesiology, Cleveland Clinic Foundation, OH 44195, USA
    Can J Anaesth 45:954-9. 1998
  4. pmc Neuromuscular block
    W C Bowman
    Department of Physiology and Pharmacology, University of Strathclyde, Glasgow G4 0NR
    Br J Pharmacol 147:S277-86. 2006
  5. ncbi Clinical pharmacokinetics of cisatracurium besilate
    D F Kisor
    Department of Pharmacy Practice, College of Pharmacy, Ohio Northern University, Ada, USA
    Clin Pharmacokinet 36:27-40. 1999
  6. ncbi The incidence and mechanisms of pharyngeal and upper esophageal dysfunction in partially paralyzed humans: pharyngeal videoradiography and simultaneous manometry after atracurium
    E Sundman
    Department of Anesthesiology, Karolinska Hospital and Institute, Stockholm, Sweden
    Anesthesiology 92:977-84. 2000
  7. ncbi Residual paralysis in the PACU after a single intubating dose of nondepolarizing muscle relaxant with an intermediate duration of action
    Bertrand Debaene
    Department of Anesthesia and Intensive Care, Hopital Jean Bernard, Poitiers, France
    Anesthesiology 98:1042-8. 2003
  8. ncbi Variability of duration of action of neuromuscular-blocking drugs in elderly patients
    S R Arain
    Department of Anaesthesiology, Medical College of Wisconsin, Zablocki VA Medical Center, Milwaukee, WI, USA
    Acta Anaesthesiol Scand 49:312-5. 2005
  9. ncbi Comparison of the neuromuscular blocking effect of cisatracurium and atracurium on the larynx and the adductor pollicis
    K Kirov
    Department of Anesthesia, Hopital Henri Mondor, AP HP, University of Paris XII, Paris, France
    Acta Anaesthesiol Scand 48:577-81. 2004
  10. ncbi Effects of atracurium added to local anesthetics on akinesia in peribulbar block
    Zuhal Kucukyavuz
    Department of Oral and Maxillofacial Surgery, Ankara University Faculty of Dentistry, Ankara, Turkey
    Reg Anesth Pain Med 27:487-90. 2002

Research Grants

Detail Information

Publications211 found, 100 shown here

  1. ncbi Effects of atracurium on intraocular pressure, eye position, and blood pressure in eucapnic and hypocapnic isoflurane-anesthetized dogs
    Rose M McMurphy
    Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    Am J Vet Res 65:179-82. 2004
    To determine effects of atracurium on intraocular pressure (IOP), eye position, and arterial blood pressure in eucapnic and hypocapnic dogs anesthetized with isoflurane.
  2. ncbi Hemodynamic effects of atracurium and cisatracurium and the use of diphenhydramine and cimetidine
    Claudia Maria Nogueira Correa
    Instituto Fernandes Figueira, FIOCRUZ
    Rev Bras Anestesiol 60:52-63. 2010
    Since atracurium can cause hypotension in humans, the hemodynamic effects of atracurium and cisatracurium as well as the hemodynamic protection of diphenhydramine and cimetidine were investigated in rats.
  3. ncbi Comparison of neuromuscular effects, efficacy and safety of rocuronium and atracurium in ambulatory anaesthesia
    D G Whalley
    Department of General Anesthesiology, Cleveland Clinic Foundation, OH 44195, USA
    Can J Anaesth 45:954-9. 1998
    To compare the neuromuscular effects, efficacy, and safety of equi-effective doses of rocuronium and atracurium in ambulatory female patients undergoing surgery.
  4. pmc Neuromuscular block
    W C Bowman
    Department of Physiology and Pharmacology, University of Strathclyde, Glasgow G4 0NR
    Br J Pharmacol 147:S277-86. 2006
    ..The nondepolarising blocking drugs are reversible acetylcholine receptor antagonists. The main ones are the atracurium group, which possess a built-in self-destruct mechanism that makes them specially useful in kidney or liver ..
  5. ncbi Clinical pharmacokinetics of cisatracurium besilate
    D F Kisor
    Department of Pharmacy Practice, College of Pharmacy, Ohio Northern University, Ada, USA
    Clin Pharmacokinet 36:27-40. 1999
    Cisatracurium besilate, one of the 10 stereoisomers that comprise atracurium besilate, is a nondepolarising neuromuscular blocking agent with an intermediate duration of action...
  6. ncbi The incidence and mechanisms of pharyngeal and upper esophageal dysfunction in partially paralyzed humans: pharyngeal videoradiography and simultaneous manometry after atracurium
    E Sundman
    Department of Anesthesiology, Karolinska Hospital and Institute, Stockholm, Sweden
    Anesthesiology 92:977-84. 2000
    ..The secondary objective was to evaluate the effect of atracurium on pharyngeal function.
  7. ncbi Residual paralysis in the PACU after a single intubating dose of nondepolarizing muscle relaxant with an intermediate duration of action
    Bertrand Debaene
    Department of Anesthesia and Intensive Care, Hopital Jean Bernard, Poitiers, France
    Anesthesiology 98:1042-8. 2003
    ....
  8. ncbi Variability of duration of action of neuromuscular-blocking drugs in elderly patients
    S R Arain
    Department of Anaesthesiology, Medical College of Wisconsin, Zablocki VA Medical Center, Milwaukee, WI, USA
    Acta Anaesthesiol Scand 49:312-5. 2005
    ..The objective of the study was to determine if elderly patients had less variability in duration of action with 2 x ED95 of cisatracurium compared to equipotent doses of rocuronium or vecuronium...
  9. ncbi Comparison of the neuromuscular blocking effect of cisatracurium and atracurium on the larynx and the adductor pollicis
    K Kirov
    Department of Anesthesia, Hopital Henri Mondor, AP HP, University of Paris XII, Paris, France
    Acta Anaesthesiol Scand 48:577-81. 2004
    Cisatracurium unlike atracurium is devoid of histamine-induced cardiovascular effects and this alone would be the greatest advantage in replacing atracurium for the facilitation of tracheal intubation...
  10. ncbi Effects of atracurium added to local anesthetics on akinesia in peribulbar block
    Zuhal Kucukyavuz
    Department of Oral and Maxillofacial Surgery, Ankara University Faculty of Dentistry, Ankara, Turkey
    Reg Anesth Pain Med 27:487-90. 2002
    ..The aim of this study was to evaluate whether addition of low-dose atracurium to the local anesthetic mixture has any effects on akinesia in PBA.
  11. ncbi Neuromuscular blockers in early acute respiratory distress syndrome
    Laurent Papazian
    Assistance Publique Hôpitaux de Marseille Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6236, Universite de la Mediterranee Aix Marseille II, Marseille, France
    N Engl J Med 363:1107-16. 2010
    ..We evaluated clinical outcomes after 2 days of therapy with neuromuscular blocking agents in patients with early, severe ARDS...
  12. ncbi The influence of atracurium, cisatracurium, and mivacurium on the proliferation of two human cell lines in vitro
    A Amann
    Department of Anesthesiology, Leopold Franzens University of Innsbruck, Austria
    Anesth Analg 93:690-6. 2001
    We tested the influence of atracurium and cisatracurium (final concentrations: 0, 0.96, 3.2, 9.6, 32, and 96 microM) on proliferation of human cells (hepatoma HepG2 cells and human umbilical vein endothelial cells) in vitro...
  13. ncbi Antagonism of low degrees of atracurium-induced neuromuscular blockade: dose-effect relationship for neostigmine
    Thomas Fuchs-Buder
    Department of Anesthesia and Critical Care, Centre Hospitalier Universitaire, Institut de la Sante et de la Recherche Medicale, CIC EC CIE6, Nancy, France
    Anesthesiology 112:34-40. 2010
    ..The purpose of this study was to investigate the dose-effect relationship of neostigmine to antagonize residual paralysis corresponding to a TOF ratio of 0.4 and 0.6...
  14. ncbi Effects of adding alfentanil or atracurium to lidocaine solution for intravenous regional anaesthesia
    N Kurt
    Adnan Menderes University, Department of Anaesthesiology and Reanimation, Faculty of Medicine, Aydin, Turkey
    Eur J Anaesthesiol 19:522-5. 2002
    The addition of alfentanil or atracurium to lidocaine solution for intravenous regional anaesthesia of the arm may have advantages with respect to improved muscle relaxation and better analgesia. The study investigates these possibilities.
  15. ncbi Atracurium is associated with postoperative residual curarization
    C McCaul
    Department of Anaesthesia, Intensive Care and Pain Medicine, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Br J Anaesth 89:766-9. 2002
    Residual paralysis following the use of neuromuscular blocking drugs remains a clinical problem. As part of departmental quality assurance, we examined the degree of postoperative residual curarization (PORC) following atracurium.
  16. ncbi Anaphylactoid reaction to cisatracurium may be explained by atracurium metabolites
    J Rieder
    Anesth Analg 96:301; author reply 301. 2003
  17. ncbi A double-blind, randomized comparison of low-dose rocuronium and atracurium in a desflurane anesthetic
    R V Miguel
    Department of Anesthesiology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, FL 33612, USA
    J Clin Anesth 13:325-9. 2001
    To compare the neuromuscular and hemodynamic effects of rocuronium and atracurium when administered during a desflurane-based anesthetic.
  18. ncbi Intraocular pressure changes during rapid sequence induction and intubation: a comparison of rocuronium, atracurium, and succinylcholine
    H R Vinik
    Department of Anesthesiology, University of Alabama Birmingham 35233, USA
    J Clin Anesth 11:95-100. 1999
    To compare changes in intraocular pressure (IOP) during rapid sequence induction and intubation following rocuronium, succinylcholine, and atracurium.
  19. ncbi Double-blind comparison of the variability in spontaneous recovery of cisatracurium- and vecuronium-induced neuromuscular block in adult and elderly patients
    F K Pühringer
    Klinikum am Steinenberg, Reutlingen, Germany
    Acta Anaesthesiol Scand 46:364-71. 2002
    ..This study was designed to compare variability in the offset of two neuromuscular blocking agents with different elimination pathways...
  20. ncbi Incidence and duration of residual paralysis at the end of surgery after multiple administrations of cisatracurium and rocuronium
    D M Maybauer
    Klinik für Anästhesiologie und Intensivmedizin, Philipps Universitat Marburg, Germany
    Anaesthesia 62:12-7. 2007
    ....
  21. ncbi [Effects of atracurium pretreatment with magnesium on speed of onset, duration, and recovery of neuromuscular blockade]
    Hong Liang Wu
    Department of Anesthesiology, Cancer Hospital, CAMS and PUMC, Beijing 100021, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 31:73-6. 2009
    To determine the effects of atracurium pretreatment with magnesium on speed of onset, duration, and recovery of neuromuscular block.
  22. ncbi Clinical pharmacokinetics of the newer neuromuscular blocking drugs
    D P Atherton
    University Department of Anaesthesia, University of Liverpool, Merseyside, England
    Clin Pharmacokinet 36:169-89. 1999
    ..Cisatracurium is the 1R-cis 1'R-cis isomer of atracurium. It has similar pharmacokinetics and pharmacodynamics to atracurium...
  23. pmc Dose requirements of continuous infusion of rocuronium and atracurium throughout orthotopic liver transplantation in humans
    Xiao Chuan Weng
    Department of Anesthesiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
    J Zhejiang Univ Sci B 6:869-72. 2005
    To compare the dose requirements of continuous infusion of rocuronium and atracurium throughout orthotopic liver transplantation (OLT) in humans.
  24. ncbi Increased sensitivity to rocuronium and atracurium in mitochondrial myopathy
    J Finsterer
    Ludwig Boltzmann Institute for Epilepsy and Neuromuscular Disorders, University of Vienna, Austria
    Can J Anaesth 45:781-4. 1998
    To describe the prolonged effect of the intermediate-acting, non-depolarising neuromuscular blocking agents rocuronium and atracurium in a 29-yr-old apparently healthy woman.
  25. ncbi Cerebrospinal fluid concentrations of atracurium, laudanosine and vecuronium following clinical subarachnoid hemorrhage
    E Tassonyi
    Department of Anesthesia, Pharmacology and Surgical Intensive Care, University Hospitals and University Medical Center CMU, Geneva, Switzerland
    Acta Anaesthesiol Scand 46:1236-41. 2002
    ..This study assessed the concentrations and the time course of passage of vecuronium, atracurium, and its metabolite laudanosine in the cerebrospinal fluid (CSF) of patients undergoing intracranial aneurysm ..
  26. ncbi Determination of atracurium, cisatracurium and mivacurium with their impurities in pharmaceutical preparations by liquid chromatography with charged aerosol detection
    Agata Błazewicz
    Department of Pharmaceutical Chemistry, National Medicines Institute, 30 34 Chełmska Street, 00 725 Warsaw, Poland
    J Chromatogr A 1217:1266-72. 2010
    ..The LC method with charged aerosol detection was developed for the determination of three isomers of atracurium, cisatracurium and also three isomers of mivacurium with their impurities...
  27. ncbi Anaesthetic management of the parturient with protein S deficiency and lumboperitoneal shunt
    Babita Gupta
    Department of Anaesthesiology, Vardhman Mahavir Medical College, Safdarjang Hospital, New Delhi, India
    Anaesth Intensive Care 31:573-5. 2003
    ..She was treated with aspirin and enoxaparin during pregnancy and underwent caesarean section under general anaesthesia without complication...
  28. ncbi [Influence of neostigmine on the course of neuromuscular blockade with rocuronium or cisatracurium: a randomized, double-blind trial]
    J Barrio
    Servicio de Anestesiologia, Hospital Arnau de Vilanova, Valencia
    Rev Esp Anestesiol Reanim 54:399-404. 2007
    ..To compare the time-course of neuromuscular blockade with rocuronium or cisatracurium during intravenous anesthesia, in terms of both the time to spontaneous recovery or time to reversal after administration of neostigmine...
  29. ncbi Atracurium, cisatracurium, vecuronium and rocuronium in patients with renal failure
    G Della Rocca
    Department of Anaesthesia, University of Udine, Udine, Italy
    Minerva Anestesiol 69:605-11, 612, 5. 2003
    The cumulative index, the recovery, the onset and the duration of action, of atracurium, cisatracurium, vecuronium and rocuronium in uremic patients undergoing kidney transplantation compared to healthy patients undergoing general surgery ..
  30. ncbi Neuromuscular blocking agents and carotid body oxygen sensing
    Malin Jonsson
    Department of Anesthesiology and Intensive Care Medicine, Karolinska Hospital and Institute, Stockholm, Sweden
    Adv Exp Med Biol 536:135-40. 2003
  31. ncbi Muscle relaxation and increasing doses of propofol improve intubating conditions
    Thomas Lieutaud
    Départements d anesthésie, Institut Gustave Roussy, Villejuif CHU de Poitiers, Poitiers, France
    Can J Anaesth 50:121-6. 2003
    ..This study was designed to determine, during intubation: i). the relative role of anesthetics and atracurium-induced neuromuscular block and; ii)...
  32. ncbi Anaesthetic management in children with metachromatic leukodystrophy
    Joaquín Hernández-Palazón
    Department of Anaesthesia, Hospital Universitario, Virgen de la Arrixaca, Murcia, Spain
    Paediatr Anaesth 13:733-4. 2003
    ..In spite of his demyelinating disease, we used a lumbar epidural technique with general anaesthesia; the epidural catheter allowed us to continue the analgesia postoperatively and to avoid opioids in this high risk patient...
  33. ncbi Consensus guidelines for sustained neuromuscular blockade in critically ill children
    Stephen Playfor
    Paediatric Intensive Care Unit, Royal Manchester Children s Hospital, Pendlebury, Manchester, UK
    Paediatr Anaesth 17:881-7. 2007
    ..However, similar clinical practice guidelines have not previously been produced for the critically ill pediatric patient...
  34. ncbi Skin reactions to intradermal neuromuscular blocking agent injections: a randomized multicenter trial in healthy volunteers
    Paul Michel Mertes
    Department of Anesthesiology, Service d Anesthesie Reanimation, Hopital Central, Centre Hospitalier Universitaire de Nancy, Unité Inserm 684, Faculte de Medecine de Nancy, France
    Anesthesiology 107:245-52. 2007
    ..Numerous reports confirm the performance of intradermal tests for the diagnosis of anaphylaxis during anesthesia; however, there is controversy over their diagnostic value regarding the newer neuromuscular blocking agents (NMBAs)...
  35. ncbi Comparisons of the dose-response and recovery time course of vecuronium and atracurium in anesthetized chinese adult patients
    Fu Shan Xue
    Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beyijng, PR of China
    Acta Anaesthesiol Taiwan 45:9-14. 2007
    The authors found no study comparing potency and duration of action of vecuronium and atracurium in healthy Chinese, so they compared the dose-response relations of vecuronium and atracurium in anesthetized Chinese adult patients and ..
  36. ncbi [Neuromuscular blockade monitoring at the corrugator supercilii and ocular myasthenia gravis]
    J M Devys
    Département d anesthésiologie réanimation urgences, Fondation Adolphe de Rothschild, 25 29, rue Manin, 75940 Paris Cedex 19, France
    Ann Fr Anesth Reanim 22:242-4. 2003
    ..We concluded that monitoring neuromuscular blockade at the corrugator supercilii to assess the intubating conditions is not recommended in a case of ocular myasthenia gravis...
  37. ncbi The relationship of posttetanic count and train-of-four responses during recovery from intense cisatracurium-induced neuromuscular blockade
    Mohammad I El-Orbany
    Department of Anesthesiology, Advocate Illinois Masonic Medical Center, Chicago 60657, USA
    Anesth Analg 97:80-4, table of contents. 2003
    ....
  38. ncbi Cisatracurium vs. Rocuronium: A prospective, comparative, randomized study in adult patients under total intravenous anaesthesia
    Milan Adamus
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital and Faculty of Medicine, Palacky University, Olomouc, Czech Republic
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 150:333-8. 2006
    ..To compare the pharmacodynamics of cisatracurium and rocuronium-induced neuromuscular block following single dose, allowing either spontaneous or neostigmine-accelerated complete recovery...
  39. ncbi [Priming technique with cisatracurium Onset time at the laryngeal muscles]
    J Schmidt
    Anästhesiologische Klinik, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen
    Anaesthesist 56:992-1000. 2007
    ..The aim of this study was to compare a bolus application and a priming technique with respect to the laryngeal onset time and peak effect...
  40. ncbi Anaesthesia for abdominal aneurysm repair in a patient with Guillain-Barré Syndrome
    H Y Yousif
    Anaesth Intensive Care 35:310-1. 2007
  41. ncbi Comparison of propofol-alfentanil and propofol-remifentanil anaesthesia in percutaneous nephrolithotripsy
    M Cicek
    Medical School of Inonu University, Department of Anaesthesiology, Malatya, Turkey
    Eur J Anaesthesiol 22:683-8. 2005
    ..We compared the effects of propofol-alfentanil or propofol-remifentanil anaesthesia on haemodynamics, recovery characteristics and postoperative analgesic requirements during percutaneous nephrolithotripsy...
  42. ncbi [Feedback control of muscle relaxation with a varying on-off controller using cisatracurium]
    B Pohl
    Klinik und Poliklinik für Anästhesiologie und Intensivtherapie, Universitat Rostock
    Anaesthesist 53:66-72. 2004
    ..However, delayed onset time, non-linearity of the dose-response curve and different sensitivity to muscle relaxants for each patient are limiting factors...
  43. ncbi Inadvertent median artery cannulation
    J F Mayhew
    Paediatr Anaesth 15:1149; author reply 1149-50. 2005
  44. ncbi Comparative study of intubating conditions at the first minute with suxamethonium, rocuronium and different priming techniques of rocuronium
    J R Ortiz-Gómez
    University Clinic, Department of Anesthesiology and Intensive Care, Navarra, Spain
    Eur J Anaesthesiol 22:263-8. 2005
    ..To evaluate orotracheal intubation conditions after 1 min...
  45. ncbi [Total intravenous anesthesia with propofol and remifentanil. Results of a multicenter study of 6,161 patients]
    J Schmidt
    Klinik fur Anasthesiologie, Friedrich Alexander Universitat, Erlangen Nurnberg
    Anaesthesist 54:17-28. 2005
    ..The aim of this study was to investigate efficacy and tolerability of propofol, remifentanil and cisatracurium or mivacurium in routine anesthetic practice...
  46. ncbi Effects of three different dose regimens of magnesium on propofol requirements, haemodynamic variables and postoperative pain relief in gynaecological surgery
    T O Seyhan
    Department of Anaesthesiology, Istanbul Medical Faculty, Istanbul University, Turkey
    Br J Anaesth 96:247-52. 2006
    ..placebo-controlled study we compared the effects of three different dose regimens of magnesium on intraoperative propofol and atracurium requirements, and postoperative morphine consumption in patients undergoing gynaecological surgery.
  47. ncbi Tracheal intubation in routine practice with and without muscular relaxation: an observational study
    C Baillard
    Hopital Avicenne, APHP, Département d Anesthésie Réanimation and SAMU 93 EA 3409, Bobigny Cedex, France
    Eur J Anaesthesiol 22:672-7. 2005
    ..There remains controversy as to whether or not a muscle relaxant is routinely required for tracheal intubation. This study examined conditions of intubation in our routine practice, which employs a relaxant-sparing approach...
  48. ncbi Antagonism of profound cisatracurium and rocuronium block: the role of objective assessment of neuromuscular function
    Aaron F Kopman
    Department of Anesthesiology, New York Medical College, Valhalla, NY, USA
    J Clin Anesth 17:30-5. 2005
    ..70), but clinically undetectable (TOF ratio >0.40), residual neuromuscular block after neostigmine antagonism of profound cisatracurium (CIS) or rocuronium (ROC) block...
  49. ncbi [Monitoring of consciousness with BIS during induction of anesthesia. Which muscle relaxant?]
    S Gazzanelli
    Dipartimento di Scienze Anestesiologiche, Medicina Critica e Terapia del Dolore, Universita degli Studi La Sapienza, Roma
    G Chir 26:163-9. 2005
    ..The BIS-index data show that an opiate as Fentanyl is advisable with associations Cisatracurium/Propofol or Vecuronium/Propofol. It is possible to use in these cases a drip infusion to avoid the risk of awareness during intubation...
  50. ncbi Neuromuscular blocking properties of atracurium during sevoflurane or propofol anaesthesia in dogs
    Marcelo R Kastrup
    Veterinary School, Fluminense Federal University, Rio de Janeiro, Brazil
    Vet Anaesth Analg 32:222-7. 2005
    To quantify the neuromuscular blockade (NMB) produced by atracurium in either sevoflurane or propofol-anaesthetized dogs.
  51. ncbi Is muscle relaxant necessary for cardiac surgery?
    G Gueret
    Departement d Anesthesie Reanimation, CHU La Cavale Blanche, 29609 Brest, France
    Anesth Analg 99:1330-3; table of contents. 2004
    ..of residual paralysis, unwanted patient movement, and difficult surgical conditions after a single dose of atracurium (0.5 mg/kg) or cisatracurium (0.15 mg/kg)...
  52. ncbi The effects of cisatracurium on morbidly obese women
    Yigal Leykin
    Department of Anesthesia, Pain, Perioperative Medicine and Intensive Care, Santa Maria degli Angeli Hospital, Pordenone, Italy
    Anesth Analg 99:1090-4, table of contents. 2004
    There is conflicting evidence on the duration of action of atracurium in obese patients. Cisatracurium is one of the stereoisomers of atracurium. We investigated the neuromuscular effects of cisatracurium in morbidly obese patients...
  53. ncbi Cisatracurium versus vecuronium: a comparative, double blind, randomized, multicenter study in adult patients under propofol/fentanyl/N2O anesthesia
    C Melloni
    Anestesia and Resuscitation Unit, City Hospital, Faenza RA, Italy
    Minerva Anestesiol 72:299-308. 2006
    ....
  54. ncbi The role of monitoring the depth of anesthesia in a case of hereditary sensory and autonomic neuropathy (Riley Day syndrome)
    Sanjib Das Adhikary
    Paediatr Anaesth 17:402-3; author reply 403. 2007
  55. ncbi Narcolepsy and cardiac surgery: can anesthesia with propofol and remifentanil be safe?
    Raquel Peláez
    Gregorioi Marañón Hospital, Madrid, Spain
    J Cardiothorac Vasc Anesth 18:201-3. 2004
  56. ncbi Assessment of neuromuscular and haemodynamic effects of cisatracurium and vecuronium under sevoflurane-remifentanil anaesthesia in elderly patients
    G T Keles
    Department of Anaesthesiology and Reanimation, Faculty of Medicine, University of Celal Bayar, Manisa, Turkey
    Eur J Anaesthesiol 21:877-81. 2004
    ..Neuromuscular block times, quality of muscle relaxation for tracheal tube insertion, and the haemodynamic effects after cisatracurium and vecuronium under sevoflurane-remifentanil anaesthesia were compared in elderly patients...
  57. ncbi Cisatracurium or rocuronium versus rocuronium-cisatracurium combination
    Ahed Zeidan
    Department of Anaesthesiology, Sahel General Hospital, Beirut, Lebanon
    Middle East J Anaesthesiol 18:879-86. 2006
    ..However, the combination of 1ED95 cisatracurium with 1ED95 rocuronium provided similar intubating conditions to the 2ED95 rocuronium alone, associated with a significantly less pain on injection...
  58. ncbi The effect of cisatracurium and rocuronium on cisatracurium precurarization and the priming principle
    Peter H K Mak
    Department of Anaesthesiology, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong, Taiwan ROC
    J Clin Anesth 16:83-7. 2004
    ..To demonstrate the effect of administering a precurarizing dose of cisatracurium or rocuronium on the speed of onset of cisatracurium, and to review the possible mechanisms and value of the priming principle...
  59. ncbi [Neuromuscular rest blockades after a single dose of a mid-term muscle relaxant]
    J U Schreiber
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar
    Anaesthesist 53:1006-8. 2004
  60. ncbi Laryngeal mask airway in patients with tracheal stents who are undergoing non-airway related interventions: report of three cases
    Wei Te Hung
    Department of Anesthesiology, Chung Shan Medical University Hospital, Taichung, Taiwan
    J Clin Anesth 16:214-6. 2004
    ..We describe three patients with a tracheal stent in place, who were anesthetized using a Laryngeal Mask Airway for surgery, with smooth results...
  61. ncbi Recovery from neuromuscular block after an intubation dose of cisatracurium and rocuronium in lumbar disc surgery
    P Hans
    University Department of Anaesthesia and ICM, CHR de la Citadelle, University Hospital, Liege, Belgium
    Acta Anaesthesiol Belg 55:129-33. 2004
    ..This study investigated the recovery from neuromuscular block (NMB) after an intubation dose of cisatracurium (C) or rocuronium (R) in 32 patients undergoing lumbar disc surgery...
  62. ncbi Is a desflurane-remifentanil based anesthetic really the best for the wake-up test?
    Olubukola O Nafiu
    Anesth Analg 101:296; author reply 296. 2005
  63. ncbi Intraoperative anisocoria in a child during renal transplantation
    C Rempf
    Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Knappschaftskrankenhaus Bochum Langendreer, University Hospital, Bochum, Germany
    Acta Anaesthesiol Scand 52:307-9. 2008
    ..A transcranial sonography was performed, showing no intracranial pathology. However, retinal hypoperfusion detected with orbital doppler sonography was a plausible explanation for anisocoria...
  64. ncbi Does pancuronium or cisatracurium delay the rate of arousal following remifentanil-based anesthesia?
    Anis S Baraka
    Department of Anesthesiology, American University of Beirut Medical Center, Beirut Lebanon
    Middle East J Anaesthesiol 18:477-84. 2005
    ....
  65. ncbi Postoperative residual curarization with cisatracurium and rocuronium infusions
    G Cammu
    Ghent University Hospital, Department of Anaesthesia, Belgium
    Eur J Anaesthesiol 19:129-34. 2002
    ..We investigated the recovery characteristics and incidence of postoperative residual curarization after cisatracurium and rocuronium infusions for long duration interventions without systematic antagonism...
  66. ncbi Fast-track method in cardiac surgery: evaluation of risks and benefits of continuous administration technique
    M Najafi
    Tehran Heart Center, Faculty of Medical Sciences, University of Tehran, North Kargar Avenue, Tehran 14117 13138, Iran
    Singapore Med J 49:470-5. 2008
    ..This study was carried out to assess the risks and benefits of conducting the fast-track method in cardiac anaesthesia and to evaluate the role of continuous infusion of short-acting anaesthetics in a successful fast-track protocol...
  67. ncbi Intraoperative awareness: detected by the structured Brice interview?
    M Enlund
    Department of Anesthesia and Intensive Care, Uppsala University Hospital, Sweden
    Acta Anaesthesiol Scand 46:345-9. 2002
    ..As a part of a quality assurance program at our short-stay surgery all patients exposed to general anesthesia are routinely subjected to a Brice interview, which aims to evaluate our standard anesthetic technique regarding awareness...
  68. ncbi Postoperative residual block after intermediate-acting neuromuscular blocking drugs
    A H Hayes
    Department of Anaesthetics and Intensive Care Medicine, The Queen's University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Anaesthesia 56:312-8. 2001
    ..neuromuscular block on arrival of 150 patients in the recovery ward following the use of vecuronium (n = 50), atracurium (n = 50) and rocuronium (n = 50) were recorded. Residual block was defined as a train-of-four ratio of <0.8...
  69. ncbi Reversal of rocuronium-induced neuromuscular block with sugammadex is faster than reversal of cisatracurium-induced block with neostigmine
    E A Flockton
    University Department of Anaesthesia, School of Clinical Sciences, Duncan Building, Daulby Street, Liverpool L69 3GA, UK
    Br J Anaesth 100:622-30. 2008
    ..The safety of sugammadex and neostigmine was also evaluated...
  70. ncbi Cisatracurium in cardiac surgery--continuous infusion vs. bolus administration
    Moosa Mirinejad
    Department of Anesthesiology, Madani Heart Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Middle East J Anaesthesiol 19:563-72. 2007
    ..3 +/- 5.1 hrs vs. Group B = 10.2 +/- 6.2 hrs, p = 0.256). These results support the intermittent bolus administration of cisatracurium in cardiac surgery following cardiopulmonary bypass...
  71. ncbi Effect of bispectral index (BIS) monitoring on postoperative recovery and sevoflurane consumption among morbidly obese patients undergoing laparoscopic gastric banding
    Osama Ibraheim
    Department of Anesthesia, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
    Middle East J Anaesthesiol 19:819-30. 2008
    ....
  72. ncbi The Thai Anesthesia Incidents Study (THAI study) of ambulatory anesthesia: II. Anesthetic profiles and adverse events
    Yodying Punjasawadwong
    Department of Anesthesiology, Chiang Mai University, Chiang Mai 50200, Thailand
    J Med Assoc Thai 91:188-95. 2008
    ..There is a continuing trend to have more elective surgery performed on an outpatient basis...
  73. ncbi Mechanisms of activation of human mast cells and basophils by general anesthetic drugs
    G Marone
    Department of Medicine, University of Naples Federico II, School of Medicine, Italy
    Ann Fr Anesth Reanim 12:116-25. 1993
    ..the effects of increasing concentrations of muscle relaxants (suxamethonium, d-tubocurarine, vecuronium, and atracurium), hypnotics (propofol, ketamine, and thiopental), opioids (morphine, buprenorphine, and fentanyl), and ..
  74. ncbi Effectiveness of a manually controlled infusion scheme of propofol and alfentanil mixture for endotracheal intubation in hypertensive patients: in comparison with thiamylal and nifedipine plus thiamylal
    T T Wei
    Department of Anesthesiology, Mackay Memorial Hospital, Taipei, Taiwan, R O C
    Acta Anaesthesiol Sin 34:9-16. 1996
    ..At the same time, the effectiveness of this scheme was compared with two other induction regimens (thiamylal or nifedipine plus thiamylal)...
  75. ncbi [Analgesic and sedative effects of multimodal analgesia in stage of emergence after general anesthesia for cleft lip and/or palate prosthesis]
    Yan Feng Tang
    Department of Anesthesiology, Second Affiliated Hospital, Wenzhou Medical College, Wenzhou 325027, China
    Zhonghua Yi Xue Za Zhi 89:906-8. 2009
    ..To investigate the effects of multimodal analgesia on analgesia and sedation during emergence of general anesthesia for cleft lip and/or palate surgery pediatric patients...
  76. ncbi Neuromuscular blocking agents' differential bronchoconstrictive potential in Guinea pig airways
    Edmund Jooste
    Department of Anesthesiology, Columbia University, New York, New York 10032, USA
    Anesthesiology 106:763-72. 2007
    ..have the potential to promote bronchoconstriction due to unintended effects exemplified by histamine release of atracurium or mivacurium and detrimental interactions with muscarinic receptors by rapacuronium...
  77. ncbi Randomized double blind comparison between sciatic-femoral nerve block and propofol-remifentanil, propofol-alfentanil general anesthetics in out-patient knee arthroscopy
    Hala Mostafa
    Department of Anesthesia, Faculty of Medicine, Cairo University, Egypt
    Pak J Biol Sci 11:359-65. 2008
    ..v followed by 9 mg kg(-1) h(-1) i.v. Patients then received atracurium 0.6 mg kg(-1) i.v. to facilitate endotracheal intubation...
  78. ncbi Anesthesia for laparoscopic general surgery. A special review
    M S Takrouri
    Department of Anesthesia, College of Medicine, King Saud University, King Khalid University Hospital KKUH
    Middle East J Anaesthesiol 15:39-62. 1999
    ..Variety of muscle relaxants including succinylcholine, mivacurium, atracurium, vecuronium aiming at rapid recovery and cardiovascular stability...
  79. ncbi [Influence of lithium on the neuromuscular blockade produced by atracurium and cisatracurium: study on rat phrenic nerve-diaphragm preparations.]
    Samanta Cristina Antoniassi Fernandes
    Departamento de Farmacologia, FCM, UNICAMP
    Rev Bras Anestesiol 57:289-300. 2007
    ..The objective of this study was to evaluate, on the rat diaphragm, the effects of lithium on the muscular response and indirect stimulation, and the possible interaction with neuromuscular blockers...
  80. ncbi [The use of curare-like agents in resuscitation]
    A Suppini
    Departement d Anesthesie Reanimation, Hopital d Instruction des Armees Sainte Anne, Toulon, France
    Ann Fr Anesth Reanim 18:341-54. 1999
    ..To analyse current data on use of neuromuscular blocking agents (NBA) in the intensive therapy unit (ITU) patients and to propose practice guidelines...
  81. ncbi Synthesis and structure-activity relationships of neuromuscular blocking agents
    Zoltan Tuba
    Steroid Research Section, Chemical Works of Gedeon Richter Ltd, 10, POB 27, Budapest, H 1475, Hungary
    Curr Med Chem 9:1507-36. 2002
    ..3) (1963), pancuronium bromide (9) (1968), vecuronium bromide (11) (1982), pipecuronium bromide (10) (1982), atracurium besylate (5) (1982), doxacurium chloride (6) (1991), mivacurium chloride (8) (1992), rocuronium bromide (12) (..
  82. ncbi Increased sensitivity to depolarization and nondepolarizing neuromuscular blocking agents in young rat hemidiaphragms
    L P Fortier
    Département d Anesthésiologie, Universite de Montreal, Quebec, Canada
    Anesthesiology 95:478-84. 2001
    ..The purpose of this study was to determine the relative sensitivity of newborn neuromuscular junctions to succinylcholine and five nondepolarizing agents...
  83. ncbi Comparison of the VBM laryngeal tube and laryngeal mask airway for ventilation during manual in-line neck stabilisation
    M Noor Zairul
    Department of Anaesthesiology and Intensive Care, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce, Kuching 93050, Sarawak, Malaysia
    Singapore Med J 47:892-6. 2006
    ..We compared the LT to the laryngeal mask airway (LMA) as an alternative airway management tool in adult patients with unstable neck and who underwent intubation with manual in-line neck stabilisation...
  84. ncbi Effects of anticholinergics on postoperative vomiting, recovery, and hospital stay in children undergoing tonsillectomy with or without adenoidectomy
    A K Chhibber
    Department of Anesthesiology and Pediatrics, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    Anesthesiology 90:697-700. 1999
    ..This study was designed to evaluate the effect of atropine and glycopyrrolate on postoperative vomiting in children...
  85. ncbi Efficacy of tramadol versus meperidine for pain relief and safe recovery after adenotonsillectomy
    Z Ozer
    Department of Anaesthesiology and Reanimation, Mersin University Medical Faculty, Mersin, Turkey
    Eur J Anaesthesiol 20:920-4. 2003
    ..We compared meperidine and tramadol when given at induction of anaesthesia with respect to their effects on postoperative pain relief and emergence characteristics after adenotonsillectomy in children...
  86. ncbi Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor
    Malin Jonsson Fagerlund
    Department of Anesthesiology and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden
    Anesthesiology 110:1244-52. 2009
    ..The aim of this study was to investigate the effect of clinically used nondepolarizing NMBAs at human adult muscle nAChRs and the mechanisms behind the inhibition...
  87. ncbi Newer neuromuscular blocking agents
    D R Bevan
    UBC Department of Anaesthesia, Vancouver General Hospital, B C, Canada
    Pharmacol Toxicol 74:3-9. 1994
    ..Two of the agents (doxacurium, mivacurium) are benzylisoquinolines resembling atracurium and two (pipecuronium, rocuronium) are aminosteroids related to pancuronium and vecuronium...
  88. ncbi [Severe hemodynamic instability during the use of isoflurane in a patient with idiopathic scoliosis: case report.]
    Adriano Bechara de Souza Hobaika
    Santa Casa de Belo Horizonte
    Rev Bras Anestesiol 57:177-81. 2007
    ..The objective of this report was to present a case of severe hemodynamic instability in a patient with idiopathic scoliosis...
  89. ncbi Does monitoring of post-tetanic count prevent alarms of airway pressure or visible muscle activity during intratracheal jet ventilation? A prospective study with five different neuromuscular blocking agents
    A I Puura
    Medical School, University of Tampere, Finland
    J Clin Monit Comput 16:523-8. 2000
    ..We studied whether monitoring of PTC prevents airway pressure alarms or visible movements of the vocal cords and the abdomen during endolaryngeal procedures (ELPs)...
  90. ncbi Screening procedure for eight quaternary nitrogen muscle relaxants in blood by high-performance liquid chromatography-electrospray ionization mass spectrometry
    V Cirimele
    Institut de Medecine Legale, 11 rue Humann, F 67085, Strasbourg, France
    J Chromatogr B Analyt Technol Biomed Life Sci 789:107-13. 2003
    ..of eight quaternary nitrogen muscle relaxants, including d-tubocurarine, alcuronium, pancuronium, vecuronium, atracurium, mivacurium, rocuronium and mebezonium, in blood samples...
  91. ncbi Differential effects of neuromuscular blockers on twitches and tetani in the isolated rat muscle: a multiple comparison study using simultaneous confidence intervals
    L H Ching
    Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    Fundam Clin Pharmacol 22:511-6. 2008
    ..of the differential effects of neuromuscular blockers on twitches and tetani was performed, encompassing: atracurium, cisatracurium, mivacurium, pancuronium, rocuronium and vecuronium...
  92. ncbi Controlled retrospective study of the effects of eyedrops containing phenylephrine hydrochloride and scopolamine hydrobromide on mean arterial blood pressure in anesthetized dogs
    Manuel Martin-Flores
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 71:1407-12. 2010
    ..To determine whether dogs that received eyedrops containing phenylephrine and scopolamine would have a higher mean arterial blood pressure (MAP) when anesthetized than would dogs that did not receive the eyedrops...
  93. ncbi Monitoring and reversal of neuromuscular block
    D R Bevan
    Department of Anesthesia, University of British Columbia, Vancouver, Canada
    Am J Health Syst Pharm 56:S10-3. 1999
    ..with a threefold greater occurrence of postoperative pulmonary complications compared with vecuronium or atracurium. Spontaneous recovery from neuromuscular block occurs through redistribution, metabolism, or buffered diffusion, ..
  94. ncbi Inspired oxygen fraction of 0.8 compared with 0.4 does not further reduce postoperative nausea and vomiting in dolasetron-treated patients undergoing laparoscopic cholecystectomy
    S N Piper
    Department of Anaesthesiology and Intensive Care Medicine, Klinikum Ludwigshafen D 67063 Ludwigshafen, Germany
    Br J Anaesth 97:647-53. 2006
    ..The aim of the study was to evaluate whether an inspired oxygen fraction of 0.8 decreases PONV in patients receiving the 5-HT3-antagonist dolasetron...
  95. ncbi The preoperative administration of ketoprofen improves analgesia after laparoscopic cholecystectomy in comparison with propacetamol or postoperative ketoprofen
    G Boccara
    Department of Anaesthesiology and Critical Care, Hospital Saint Joseph, 75674 Paris, France
    Br J Anaesth 94:347-51. 2005
    ..We compared perioperative propacetamol (P) and ketoprofen (K) to provide analgesia after laparoscopic cholecystectomy...
  96. ncbi Combination therapy in the prevention of PONV after strabismus surgery in children: granisetron, ondansetron, midazolam with dexamethasone
    Waleed Riad
    Dept of Anesthesia, King Khaled Eye Specialist Hospital, P O Box 7191, Riyadh 11462, Kingdom of Saudi Arabia
    Middle East J Anaesthesiol 20:431-6. 2009
    ..The aim of this study was to investigate the effect of granisetron, ondansetron, midazolam combination with dexamethasone in the prevention of PONV following strabismus repair in pediatric population...
  97. ncbi Elevated vascular resistance after labetalol during resection of a pheochromocytoma (brief report)
    Peter C H Chung
    Department of Anesthesiology, Chang Gung Memorial Hospital, Tao Yuan, Taiwan
    Can J Anaesth 49:148-50. 2002
    ..To report a case of pheochromocytoma exhibiting an increase in systemic vascular resistance index (SVRI) and decreased cardiac index (CI) after use of labetalol...
  98. ncbi Newer neuromuscular blocking drugs. An overview of their clinical pharmacology and therapeutic use
    R K Mirakhur
    Department of Anaesthetics, Queen s University, Belfast, Northern Ireland
    Drugs 44:182-99. 1992
    ..doxacurium chloride, mivacurium chloride and Org 9426 (rocuronium) offer alternatives to the established agents atracurium besilate and vecuronium bromide...
  99. ncbi Effect of magnesium sulfate infusion on sevoflurane consumption, hemodynamics, and perioperative opioid consumption in lumbar disc surgery
    Nihal Oguzhan
    Department of Anesthesiology, Trakya University, Turkey
    J Opioid Manag 4:105-10. 2008
    ....
  100. ncbi Propofol reduces succinylcholine induced increase of masseter muscle tone
    W C Ummenhofer
    Department of Anaesthesia, University of Basel, Kantonsspital, Switzerland
    Can J Anaesth 45:417-23. 1998
    ....
  101. ncbi [Pharmacology of sugammadex]
    C Meistelman
    Departement d Anesthesie Reanimation, CHU de Brabois, rue du Morvan, 54500 Vandoeuvre Nancy, France
    Ann Fr Anesth Reanim 28:S51-6. 2009
    ..It cannot reverse neuromuscular block induced by succinylcholine or benzylisoquinolines such as atracurium or cisatracurium...

Research Grants3

  1. PHYSIOLOGIC RESPONSE TO THERMAL INJURY
    EDWARD PAVLIN; Fiscal Year: 1990
    ..We have demonstrated that resistance to atracurium (a new short-acting NDMR) develops after 7 days post injury, peaks at 30-50 days, decreases by 90 days, and is ..
  2. PARALYSIS--ITS ANTAGONISM DURING SURGERY AND ANESTHESIA
    Ronald Miller; Fiscal Year: 1990
    ..Third, the basic and clinical pharmacology of atracurium will be studied focusing on the quantitative and qualitative analysis of its spontaneous and enzyme-mediated ..
  3. Exacerbation of Alzheimer's Disease by Nitrous Oxide
    W Kofke; Fiscal Year: 2003
    ..Moreover, observation of a protective effect may result in discovery of an easily implemented preventative drug therapy for AD. ..