perindopril

Summary

Summary: An angiotensin-converting enzyme inhibitor. It is used in patients with hypertension and heart failure.

Top Publications

  1. ncbi Comparison of different therapeutic strategies in hypertension: a low-dose combination of perindopril/indapamide versus a sequential monotherapy or a stepped-care approach
    Jean Jacques Mourad
    Jean Jacques Mourad, Department of Internal Medicine, Avicenne Hospital, Bobigny, France
    J Hypertens 22:2379-86. 2004
  2. ncbi Treatment of hypertension in patients 80 years of age or older
    Nigel S Beckett
    Care of the Elderly, Division of Medicine, Imperial College London, United Kingdom
    N Engl J Med 358:1887-98. 2008
  3. ncbi Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-B
    Bjorn Dahlof
    Department of Medicine, Sahlgrenska University Hospital Ostra, SE 416 85 Goteborg, Sweden
    Lancet 366:895-906. 2005
  4. ncbi The perindopril in elderly people with chronic heart failure (PEP-CHF) study
    John G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, Kingston upon Hull HU16 5JQ, UK
    Eur Heart J 27:2338-45. 2006
  5. pmc Comparative study of Mg/Al- and Zn/Al-layered double hydroxide-perindopril erbumine nanocomposites for inhibition of angiotensin-converting enzyme
    Samer Hasan Hussein Al Ali
    Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
    Int J Nanomedicine 7:4251-62. 2012
  6. pmc Protective effect of perindopril on diabetic retinopathy is associated with decreased vascular endothelial growth factor-to-pigment epithelium-derived factor ratio: involvement of a mitochondria-reactive oxygen species pathway
    Zhi Zheng
    Department of Ophthalmology, First People s Hospital of Shanghai, Shanghai Jiaotong University, Shanghai, China
    Diabetes 58:954-64. 2009
  7. pmc Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial
    Deepa Sumukadas
    Section of Ageing and Health, University of Dundee, Dundee, UK
    CMAJ 177:867-74. 2007
  8. ncbi Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Circulation 113:1213-25. 2006
  9. ncbi Mechanism(s) of selective systolic blood pressure reduction after a low-dose combination of perindopril/indapamide in hypertensive subjects: comparison with atenolol
    Gerard M London
    Hopital Manhes, Fleury Merogis, France
    J Am Coll Cardiol 43:92-9. 2004
  10. ncbi Long-term effect of perindopril on coronary atherosclerosis progression (from the perindopril's prospective effect on coronary atherosclerosis by angiography and intravascular ultrasound evaluation [PERSPECTIVE] study)
    Gaston A Rodriguez-Granillo
    Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
    Am J Cardiol 100:159-63. 2007

Research Grants

  1. Perindopril-Methamphetamine Interaction Study
    Thomas Newton; Fiscal Year: 2006
  2. An ACE Inhibitor as a Treatment for Methamphetamine Dependence
    THOMAS FREDERICK NEWTON; Fiscal Year: 2012
  3. PREDICTORS OF RECURRENT STROKE IN THE PROGRESS STUDY
    Duncan Campbell; Fiscal Year: 2003
  4. ADVENTITIAL RESPONSE TO VASCULAR INJURY: ESTROGEN
    Suzanne Oparil; Fiscal Year: 2003
  5. Estrogen Modulates Injury-Induced Inflammation
    Suzanne Oparil; Fiscal Year: 2007
  6. MORPHOLOGY AND FUNCTION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 2006
  7. Oxidative Stress and Genetics of Prehypertension
    Shawna Nesbitt; Fiscal Year: 2004
  8. Laboratory Models of Cocaine Self-Administration
    Thomas Newton; Fiscal Year: 2008

Detail Information

Publications231 found, 100 shown here

  1. ncbi Comparison of different therapeutic strategies in hypertension: a low-dose combination of perindopril/indapamide versus a sequential monotherapy or a stepped-care approach
    Jean Jacques Mourad
    Jean Jacques Mourad, Department of Internal Medicine, Avicenne Hospital, Bobigny, France
    J Hypertens 22:2379-86. 2004
    ..To compare the efficacy and the tolerability of three different strategies in the treatment of hypertension (low-dose combination, sequential monotherapy and stepped-care)...
  2. ncbi Treatment of hypertension in patients 80 years of age or older
    Nigel S Beckett
    Care of the Elderly, Division of Medicine, Imperial College London, United Kingdom
    N Engl J Med 358:1887-98. 2008
    ..Whether the treatment of patients with hypertension who are 80 years of age or older is beneficial is unclear. It has been suggested that antihypertensive therapy may reduce the risk of stroke, despite possibly increasing the risk of death...
  3. ncbi Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-B
    Bjorn Dahlof
    Department of Medicine, Sahlgrenska University Hospital Ostra, SE 416 85 Goteborg, Sweden
    Lancet 366:895-906. 2005
    ..Our aim, therefore, was to compare the effect on non-fatal myocardial infarction and fatal CHD of combinations of atenolol with a thiazide versus amlodipine with perindopril.
  4. ncbi The perindopril in elderly people with chronic heart failure (PEP-CHF) study
    John G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, Kingston upon Hull HU16 5JQ, UK
    Eur Heart J 27:2338-45. 2006
    ..Few substantial randomized controlled trials have been conducted in this population, none has focussed on patients with evidence of diastolic dysfunction and none has shown clear benefit on symptoms, morbidity, or mortality...
  5. pmc Comparative study of Mg/Al- and Zn/Al-layered double hydroxide-perindopril erbumine nanocomposites for inhibition of angiotensin-converting enzyme
    Samer Hasan Hussein Al Ali
    Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
    Int J Nanomedicine 7:4251-62. 2012
    The intercalation of a drug active, perindopril, into Mg/Al-layered double hydroxide for the formation of a new nanocomposite, PMAE, was accomplished using a simple ion exchange technique...
  6. pmc Protective effect of perindopril on diabetic retinopathy is associated with decreased vascular endothelial growth factor-to-pigment epithelium-derived factor ratio: involvement of a mitochondria-reactive oxygen species pathway
    Zhi Zheng
    Department of Ophthalmology, First People s Hospital of Shanghai, Shanghai Jiaotong University, Shanghai, China
    Diabetes 58:954-64. 2009
    ....
  7. pmc Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial
    Deepa Sumukadas
    Section of Ageing and Health, University of Dundee, Dundee, UK
    CMAJ 177:867-74. 2007
    ..We sought to examine the effect of the angiotensin-converting-enzyme (ACE) inhibitor perindopril on physical function in elderly people with functional impairment who had no heart failure or left ventricular ..
  8. ncbi Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Circulation 113:1213-25. 2006
    ..Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT), examined the impact of 2 different BP lowering-regimens (atenolol+/-thiazide-based versus amlodipine+/-perindopril-based therapy) on derived central aortic pressures and hemodynamics.
  9. ncbi Mechanism(s) of selective systolic blood pressure reduction after a low-dose combination of perindopril/indapamide in hypertensive subjects: comparison with atenolol
    Gerard M London
    Hopital Manhes, Fleury Merogis, France
    J Am Coll Cardiol 43:92-9. 2004
    The goal of this study was to determine if a low-dose combination of the angiotensin-converting enzyme inhibitor perindopril (Per) and the diuretic indapamide (Ind) reduces central (thoracic aorta, carotid artery) as well as brachial ..
  10. ncbi Long-term effect of perindopril on coronary atherosclerosis progression (from the perindopril's prospective effect on coronary atherosclerosis by angiography and intravascular ultrasound evaluation [PERSPECTIVE] study)
    Gaston A Rodriguez-Granillo
    Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
    Am J Cardiol 100:159-63. 2007
    The multicenter EUROPA trial of 12,218 patients showed that perindopril decreased adverse clinical events in patients with established coronary heart disease...
  11. ncbi Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study)
    K M Fox
    Cardiology Department, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Lancet 362:782-8. 2003
    ..We assessed whether the ACE inhibitor perindopril reduced cardiovascular risk in a low-risk population with stable coronary heart disease and no apparent heart ..
  12. ncbi The Perindopril Protection Against Recurrent Stroke Study (PROGRESS): clinical implications for older patients with cerebrovascular disease
    Yogini Ratnasabapathy
    Clinical Trials Research Unit, University of Auckland, Auckland, New Zealand
    Drugs Aging 20:241-51. 2003
    ..specifically in older patients with a history of stroke, with particular attention paid to the results from the Perindopril Protection Against Recurrent Stroke Study (PROGRESS)...
  13. ncbi Repair of coronary arterioles after treatment with perindopril in hypertensive heart disease
    B Schwartzkopff
    Department of Cardiology, Pneumology and Angiology, Heinrich Heine University, Dusseldorf, Germany
    Hypertension 36:220-5. 2000
    ..and with transvenous endomyocardial biopsy before and after 12 months of antihypertensive treatment with perindopril (4 to 8 mg/d, mean 5.9+/-2.3 mg/d)...
  14. ncbi Effects of a perindopril-based blood pressure-lowering regimen on the risk of recurrent stroke according to stroke subtype and medical history: the PROGRESS Trial
    N Chapman
    St Mary s Hospital, London, UK
    Stroke 35:116-21. 2004
    The Perindopril Protection Against Recurrent Stroke Study (PROGRESS) showed that blood pressure lowering reduced stroke risk in patients with a history of cerebrovascular events...
  15. ncbi Effects of a fixed combination of perindopril and indapamide in patients with type 2 diabetes and chronic kidney disease
    Hiddo J Lambers Heerspink
    The George Institute for International Health, University of Sydney, Missenden Road, Camperdown, Sydney, NSW 2050, Australia
    Eur Heart J 31:2888-96. 2010
    ..In these analyses of the ADVANCE trial, we assessed the effects of a fixed combination of perindopril-indapamide on renal and cardiovascular outcomes in patients with type 2 diabetes according to baseline CKD stage...
  16. ncbi Efficacy of Sevikar® compared to the combination of perindopril plus amlodipine on central arterial blood pressure in patients with moderate-to-severe hypertension: Rationale and design of the SEVITENSION study
    Luis M Ruilope
    Hypertension Unit, Hospital 12 de Octubre, 28041 Madrid, Spain
    Contemp Clin Trials 32:710-6. 2011
    ..sub-study of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) investigated the effects of amlodipine/perindopril and atenolol/bendroflumethiazide on central aortic blood pressure (CABP)...
  17. pmc Reduced cardiac expression of plasminogen activator inhibitor 1 and transforming growth factor beta1 in obese Zucker rats by perindopril
    J E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, CONICET, Av Pueyrredon 1640, Buenos Aires 1118, Argentina
    Heart 91:80-6. 2005
    To determine whether angiotensin converting enzyme inhibition by perindopril can reduce cardiac transforming growth factor beta1 (TGFbeta1) and plasminogen activator inhibitor 1 (PAI-1) and therefore control collagen accumulation in an ..
  18. pmc Controlled release and angiotensin-converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine-layered double hydroxide nanocomposite
    Samer Hasan Hussein Al Ali
    Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
    Int J Nanomedicine 7:2129-41. 2012
    The intercalation of perindopril erbumine into Zn/Al-NO(3)-layered double hydroxide resulted in the formation of a host-guest type of material...
  19. ncbi Blood pressure lowering with fixed combination perindopril-indapamide: key findings from ADVANCE
    John Chalmers
    The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Sydney NSW 2050, Australia
    J Hypertens Suppl 26:S11-5. 2008
    ADVANCE was planned to investigate the effects of routine blood pressure lowering with the fixed combination perindopril-indapamide on major vascular events in people with type 2 diabetes, irrespective of initial blood pressures or the ..
  20. ncbi Urinary N-acetyl B glucosaminidase as an earlier marker of diabetic nephropathy and influence of low-dose perindopril/indapamide combination
    T Basturk
    Sisli Etfal Education and Research Hospital, Nephrology Department, Istanbul, Turkey
    Ren Fail 28:125-8. 2006
    ..N-Acetyl B glucosaminidase (NAG) is derived from proximal tubular cells and is widely used to evaluate tubular renal function...
  21. ncbi Treatment benefit by perindopril in patients with stable coronary artery disease at different levels of risk
    Jaap W Deckers
    Department of Cardiology, Thoraxcenter, Erasmus University Medical Center Rotterdam, The Netherlands
    Eur Heart J 27:796-801. 2006
    ..We developed a cardiovascular risk model based on the EUROPA study population and investigated whether benefit of long-term administration of the angiotensin-converting enzyme (ACE)-inhibitor perindopril was modified by risk level.
  22. ncbi Aliskiren and perindopril reduce the levels of transforming growth factor-β in patients with non-diabetic kidney disease
    Sławomir Lizakowski
    Department of Nephrology, Transplantation and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Am J Hypertens 25:636-9. 2012
    ....
  23. ncbi ACE inhibition with perindopril and endothelial function. Results of a substudy of the EUROPA study: PERTINENT
    Claudio Ceconi
    University of Ferrara and Cardiovascular Pathophysiology Research Centre, Salvatore Maugeri Foundation, IRCCS, Gussago Brescia, Italy
    Cardiovasc Res 73:237-46. 2007
    EUropean trial on Reduction Of cardiac events with Perindopril in stable coronary Artery disease [EUROPA] demonstrates reduction in cardiovascular mortality and myocardial infarction for a possible vascular and antiatherosclerotic effect ..
  24. ncbi Effects of perindopril-based lowering of blood pressure on intracerebral hemorrhage related to amyloid angiopathy: the PROGRESS trial
    Hisatomi Arima
    The George Institute for International Health, University of Sydney and The Royal Prince Alfred Hospital, Sydney, Australia
    Stroke 41:394-6. 2010
    ..The objective is to determine whether lowering of blood pressure (BP) provides protection for this high-risk patient group...
  25. ncbi Effect of perindopril on large artery stiffness and aortic root diameter in patients with Marfan syndrome: a randomized controlled trial
    Anna A Ahimastos
    Alfred and Baker Medical Unit, Baker Heart Research Institute, Central Melbourne, Victoria, Australia
    JAMA 298:1539-47. 2007
    ..Aortic stiffness is increased in Marfan syndrome contributing to aortic dilatation and rupture, the major cause of premature death in this population. Angiotensin-converting enzyme inhibitors have been shown to reduce arterial stiffness...
  26. ncbi Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial
    Anushka Patel
    Cardiovascular Division, The George Institute for International Health, University of Sydney, PO Box M201, Missenden Road, Sydney, NSW 2050, Australia
    Lancet 370:829-40. 2007
    ....
  27. ncbi Effect of perindopril on the onset and progression of left ventricular dysfunction in Duchenne muscular dystrophy
    Denis Duboc
    French Working Group of Heart Involvement in Myopathies Investigators, Paris, France
    J Am Coll Cardiol 45:855-7. 2005
    The aim of this research was to examine the effects of perindopril on cardiac function in patients with Duchenne muscular dystrophy (DMD).
  28. ncbi Angiotensin-converting enzyme inhibition and angiogenesis in myocardium of obese Zucker rats
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, CONICET, Av Pueyrredon 1640, Buenos Aires 1118, Argentina
    Am J Hypertens 17:172-80. 2004
    ..The present study was designed to determine the possible beneficial effects of an ACE inhibitor perindopril on myocardial angiogenesis in an animal model of obesity, hypertension, and NIDDM, such as the obese Zucker rat ..
  29. ncbi Perindopril: an updated review of its use in hypertension
    M Hurst
    Adis International Limited, Mairangi Bay, Auckland, New Zealand
    Drugs 61:867-96. 2001
    b>Perindopril erbumine (perindopril) is a prodrug ester of perindoprilat, an angiotensin converting enzyme (ACE) inhibitor...
  30. ncbi Effect of a centrally active angiotensin converting enzyme inhibitor, perindopril, on cognitive performance in chronic cerebral hypo-perfusion rats
    Koji Yamada
    Pharmacological Research Laboratories, Research Division, Kyowa Hakko Kirin Co, Ltd, 1188 Shimotogari, Nagaizumi cho, Sunto gun, Shizuoka 411 8731, Japan
    Brain Res 1421:110-20. 2011
    We have previously demonstrated that perindopril, an angiotensin-converting enzyme (ACE) inhibitor, ameliorated the cognitive deficits in Alzheimer's disease model animals, independently of its anti-hypertensive effect...
  31. ncbi Effects of angiotensin-converting enzyme inhibitor and exercise training on exercise capacity and skeletal muscle
    Naoyoshi Minami
    Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Hypertens 25:1241-8. 2007
    ..We examined the effects of angiotensin-converting enzyme inhibitor, exercise training and their combination on exercise capacity as well as skeletal muscle fiber type and capillarity in spontaneously hypertensive rats (SHR)...
  32. ncbi Effects of atenolol, perindopril and verapamil on haemodynamic and vascular function in Marfan syndrome - a randomised, double-blind, crossover trial
    Andrew Williams
    Wales Heart Research Institute, Cardiff University, UK
    Eur J Clin Invest 42:891-9. 2012
    ..We therefore performed a prospective, randomised, double-blind, crossover trial to compare the effects of these three agents on large artery function and central aortic pressure in patients with Marfan syndrome...
  33. ncbi Effects of the angiotensin I converting enzyme inhibitor perindopril on cerebral blood flow in awake hypertensive rats
    L Bray
    Laboratoire de Pharmacologie Cardio-vasculaire, , Nancy, France
    Am J Hypertens 4:246S-252S. 1991
    ..to higher pressure levels, we studied the effects of the angiotensin converting enzyme (ACE) inhibitor, perindopril on mean arterial pressure (mean BP), basal CBF, and CBF autoregulation in awake renovascular hypertensive (2 ..
  34. ncbi Perindopril/indapamide combination more effective than enalapril in reducing blood pressure and left ventricular mass: the PICXEL study
    Bjorn Dahlof
    Goteborg University, Sweden
    J Hypertens 23:2063-70. 2005
    ..The PICXEL study compared the efficacy of a strategy based on first-line combination with perindopril/indapamide versus monotherapy with enalapril in reducing left ventricular hypertrophy (LVH) in hypertensive ..
  35. ncbi Combination of interferon and angiotensin-converting enzyme inhibitor, perindopril, suppresses liver carcinogenesis and angiogenesis in mice
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Shijo cho 840, Kashihara, Nara 634 8522, Japan
    Oncol Rep 13:491-5. 2005
    ..combination effect of the clinically used interferon-beta (IFN) and angiotensin-converting enzyme inhibitor, perindopril (PE), on hepatocarcinogenesis induced by diethylnitrosamine, especially in conjunction with angiogenesis...
  36. ncbi Perindopril and indapamide reverse coronary microvascular remodelling and improve flow in arterial hypertension
    Danilo Neglia
    Fondazione G Monasterio CNR Regione Toscana, Pisa, Italy
    J Hypertens 29:364-72. 2011
    ..Using a translational approach, we ascertained whether antihypertensive treatment can reverse microvascular remodelling and improve myocardial perfusion...
  37. pmc Perindopril improves six minute walking distance in older patients with left ventricular systolic dysfunction: a randomised double blind placebo controlled trial
    S D Hutcheon
    Section of Ageing and Health, Department of Medicine, University of Dundee, Ninewells Hospital, Dundee, UK
    Heart 88:373-7. 2002
    To evaluate the effects of the angiotensin converting enzyme inhibitor perindopril on six minute walking distance and quality of life in very old patients with left ventricular systolic dysfunction.
  38. ncbi Effects of estradiol, angiotensin-converting enzyme inhibitor and exercise training on exercise capacity and skeletal muscle in old female rats
    Qi Guo
    Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    Clin Exp Hypertens 32:76-83. 2010
    ..025 mg/kg/dose, i.p. twice a week) (Est), perindopril (2 mg/kg/day) (Per), exercise training on a treadmill (15 m/min, 10 grade incline, 60 min/day, 5 days/week) (..
  39. ncbi [Perindopril, amlodipine and telmisartan improve arterial stiffness in patients with hypertension]
    Yan Li
    Department of Gerontology, Shengjing Affiliated Hospital, China Medical University, Shenyang 110004, China
    Zhonghua Xin Xue Guan Bing Za Zhi 37:908-12. 2009
    To investigate the effect of perindopril, amlodipine and telmisartan on improving the artery stiffness in patients with hypertension.
  40. ncbi Randomized trial of perindopril, enalapril, losartan and telmisartan in overweight or obese patients with hypertension
    Sergey V Nedogoda
    Volgograd State Medical University, Volgograd, Russia
    Clin Drug Investig 33:553-61. 2013
    ..This study compared four RAAS inhibitors at full therapeutic doses to determine their effect on blood pressure (BP) and cardiovascular risk factors in these patients...
  41. ncbi Evidence for benefits of perindopril in hypertension and its complications
    Stephane Laurent
    Department of Pharmacology and INSERM U652, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
    Am J Hypertens 18:155S-162S. 2005
    ..clinical trials, that has been gathered in regard to the angiotensin-converting enzyme (ACE) inhibitor perindopril, demonstrating its efficacy in reducing BP, reversing abnormalities of vascular structure and function in ..
  42. ncbi Decreased muscle ACE activity enhances functional response to endurance training in rats, without change in muscle oxidative capacity or contractile phenotype
    Estelle Habouzit
    Département des Facteurs Humains, Centre de Recherches du Service de Sante des Armees, F 38700 La Tronche, France
    J Appl Physiol (1985) 107:346-53. 2009
    ..sedentary or endurance trained (Sed and Tr, respectively), and treated or not for 10 wk with an ACE inhibitor, perindopril (2 mg.kg(-1).day(-1)) (Per and Ct, respectively) (n = 8 each)...
  43. ncbi Blood pressure and metabolic efficacy of fixed-dose combination of perindopril and indapamide in everyday practice
    Csaba Farsang
    Cardiometabolic Centre, St Imre Teaching Hospital, Budapest H 1115, Hungary
    Blood Press 22:3-10. 2013
    The aim of the PICASSO study was to evaluate the efficacy and safety of fixed-dose perindopril 10 mg/indapamide 2.5 mg in everyday medical practice...
  44. ncbi Inhibition of AAA in a rat model by treatment with ACEI perindopril
    Fei Xiong
    Department of Vascular Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China
    J Surg Res 189:166-73. 2014
    The purpose of the present study was to evaluate the effect of a new angiotensin converting enzyme inhibitor perindopril on the formation of experimental abdominal aortic aneurysms (AAAs) in a rat model induced by intraluminal elastase ..
  45. ncbi Combination of interferon-beta and angiotensin-converting enzyme inhibitor, perindopril, attenuates the murine liver fibrosis development
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Japan
    Liver Int 25:153-61. 2005
    ..A model of CCl(4)-induced hepatic fibrosis was used to assess the effect of the clinically used ACE-I, perindopril (PE), and IFN-beta...
  46. ncbi Twenty-four-hour ambulatory blood pressure monitoring efficacy of perindopril/indapamide first-line combination in hypertensive patients: the REASON study
    Jean Michel Mallion
    Cardiologie et Hypertension Arterielle, Service de Médecine Interne et Cardiologie, Hopital A Michallon CHU, BP 217, 38043 Grenoble Cedex, France
    Am J Hypertens 17:245-51. 2004
    ..The purpose of this study was to analyze the efficacy of the first-line combination of perindopril 2 mg plus indapamide 0...
  47. ncbi Impact of the therapy by renin-angiotensin system targeting antihypertensive agents perindopril versus telmisartan on prothrombotic state in essential hypertension
    A Remkova
    Department of Internal Medicine, School of Medicine, Comenius University in Bratislava, Bratislava, Slovak Republic
    J Hum Hypertens 22:338-45. 2008
    The aim of the study was to investigate the effect of therapy by perindopril or telmisartan on endothelial/platelet function and on coagulation/fibrinolysis in 20 and 16 hypertensive patients, respectively...
  48. ncbi Antihypertensive utility of perindopril in a large, general practice-based clinical trial
    Stevo Julius
    Division of Hypertension, University of Michigan, Ann Arbor, MI 48109, USA
    J Clin Hypertens (Greenwich) 6:10-7. 2004
    The authors evaluated, in a community-based open-label trial, the effectiveness and safety of perindopril in 13,220 US hypertensive patients and studied how physicians adhere to hypertension treatment guidelines...
  49. ncbi Very-low-dose combination of the angiotensin-converting enzyme inhibitor perindopril and the diuretic indapamide induces an early and sustained increase in neovascularization in rat ischemic legs
    Jean Sebastien Silvestre
    Institut National de la Santé et de la Recherche Médicale U541, Hopital Lariboisiere, Universite Paris, Paris, France
    J Pharmacol Exp Ther 303:1038-43. 2002
    ..This study examined the possible role of the very-low-dose combination of perindopril (angiotensin-converting enzyme inhibitor) and indapamide (diuretic), used first-line in the treatment of ..
  50. ncbi Long-term renoprotection by perindopril or nifedipine in non-hypertensive patients with Type 2 diabetes and microalbuminuria
    G Jerums
    Department of Medicine, University of Melbourne, and Endocrinology Unit, Austin Health, Studley Road, Heidelberg, 3084 Victoria, Australia
    Diabet Med 21:1192-9. 2004
    To assess the efficacy of an angiotensin converting enzyme (ACE) inhibitor (perindopril), a dihydropyridine calcium channel blocker (sustained release nifedipine) and placebo in preventing the progression of albuminuria and decline in ..
  51. ncbi Effects of valsartan and perindopril combination therapy on left ventricular hypertrophy and aortic arterial stiffness in patients with essential hypertension
    Futoshi Anan
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita, 879 5593, Japan
    Eur J Clin Pharmacol 61:353-9. 2005
    ..of an angiotensin II receptor blocker (ARB; valsartan) and an angiotensin converting enzyme inhibitor (ACEI; perindopril) on blood pressure (BP), metabolic profiles, plasma brain natriuretic peptide (BNP) levels, echocardiographic ..
  52. ncbi Combinations of inhibitors of the renin-angiotensin system with calcium channel blockers for the treatment of hypertension: focus on perindopril/amlodipine
    Jean Jacques Mourad
    Dept of Internal Medicine and Arterial Hypertension, Avicenne Hospital, Bobigny Cedex, France
    Curr Med Res Opin 26:2263-76. 2010
    ..This article reviews the rationale for, and evidence supporting, the use of newer fixed-dose combinations of RAS inhibitors and CCBs, with particular emphasis on perindopril/amlodipine.
  53. ncbi The effects of perindopril on aortic elasticity and inflammatory markers in hypertensive patients
    Cem Koz
    Department of Cardiology, Gulhane Military Medical School, Etlik, Ankara, Turkey
    Med Sci Monit 15:PI41-5. 2009
    ..Inflammatory changes induced even in prehypertensive subjects can lead to increased arterial stiffness. The effects of perindopril on both inflammatory and aortic elasticity markers were tested in hypertensive patients.
  54. ncbi Optimizing the treatment of hypertension and stable coronary artery disease: clinical evidence for fixed-combination perindopril/amlodipine
    Roberto Ferrari
    University of Ferrara, Italy and Fondazione Salvatore Maugeri IRCCS, Ferrara, Italy
    Curr Med Res Opin 24:3543-57. 2008
    ..This article reviews evidence for the fixed combination of the angiotensin-converting enzyme (ACE) inhibitor perindopril and the calcium channel blocker amlodipine.
  55. ncbi Costs and effects of secondary prevention with perindopril in stable coronary heart disease in Poland: an analysis of the EUROPA study including 1251 Polish patients
    W Ken Redekop
    Institute for Medical Technology Assessment and Institute of Health Policy and Management, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Pharmacoeconomics 26:861-77. 2008
    To estimate the long-term impact of treatment with perindopril on costs and health effects in patients with stable coronary artery disease in Poland.
  56. ncbi Molecular structure and stability of perindopril erbumine and perindopril L-arginine complexes
    Milan Remko
    Comenius University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Odbojarov 10, SK 832 32 Bratislava, Slovakia
    Eur J Med Chem 44:101-8. 2009
    ..used to elucidate molecular properties of the antihypertensive, cardiovascular protective and antithrombotic perindopril ((2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-..
  57. ncbi Clinical experience with perindopril in African-American hypertensive patients: a large United States community trial
    Jay N Cohn
    Cardiovascular Division, University of Minnesota Medical School, Box 508, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Am J Hypertens 17:134-8. 2004
    ..The prevalence of hypertension is greater in African Americans, and management of this condition presents challenges for practicing physicians...
  58. ncbi Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease
    Yi Fei Dong
    Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860 8556, Japan
    FASEB J 25:2911-20. 2011
    ..g., perindopril), as opposed to non-brain-penetrating ACE inhibitors (e.g...
  59. ncbi Effects of irbesartan and perindopril on forearm reactive hyperemia and inflammatory process, in normotensive patients with coronary artery disease
    Dimitris Tousoulis
    Int J Cardiol 124:127-9. 2008
  60. ncbi Perindopril-based blood pressure-lowering reduces major vascular events in patients with atrial fibrillation and prior stroke or transient ischemic attack
    Hisatomi Arima
    George Institute for International Health, University of Sydney, Australia
    Stroke 36:2164-9. 2005
    ..The primary objective here is to determine whether routine blood pressure-lowering provides additional protection for this high-risk patient group...
  61. ncbi Effects of perindopril on elastic and structural properties of large arteries in essential hypertension
    Yves Lacourciere
    Centre hospitalier de l Universite Laval, Sainte Foy, Quebec
    Can J Cardiol 20:795-9. 2004
    b>Perindopril, an angiotensin-converting enzyme (ACE) inhibitor, is a well-recognized antihypertensive drug. Its ability to protect against cardiovascular events in hypertension has also been demonstrated...
  62. ncbi Combination of the angiotensin-converting enzyme inhibitor perindopril and the diuretic indapamide activate postnatal vasculogenesis in spontaneously hypertensive rats
    Dong You
    Institut National de la Sante et de la Recherche Medicale, Unité 689, Hopital Lariboisiere, 41 Blvd de la Chapelle, 75475 Paris Cedex 10, France
    J Pharmacol Exp Ther 325:766-73. 2008
    ..hypertension abrogates postnatal vasculogenesis, and 2) antihypertensive treatment based on the combination of perindopril (angiotensin-converting enzyme inhibitor) and indapamide (diuretic) may counteract hypertension-induced ..
  63. ncbi Effects of perindopril and valsartan on expression of transforming growth factor-beta-Smads in experimental hepatic fibrosis in rats
    Wei Xu
    Department of Infectious Diseases, Renmin Hospital, State Key Laboratory of Virology, Wuhan University, Wuhan, China
    J Gastroenterol Hepatol 21:1250-6. 2006
    ..aim of this study was to investigate the effect and mechanism of an angiotensin-converting enzyme inhibitor (perindopril) and an angiotensin II receptor blocker (valsartan) on TGF-beta1 and TGF receptor II (TRII) mRNA, Smad3 and ..
  64. pmc Bone marrow mesenchymal stem cell transplantation combined with perindopril treatment attenuates infarction remodelling in a rat model of acute myocardial infarction
    Jian An Wang
    Department of Cardiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
    J Zhejiang Univ Sci B 7:641-7. 2006
    ..of mesenchymal stem cell (MSC) would reduce left ventricular remodelling from the molecular mechanisms compared with angiotensin-converting enzyme inhibitors (ACEIs) perindopril into ischemic myocardium after acute myocardial infarction.
  65. ncbi Effect of perindopril on cerebral and renal perfusion on normotensives in mild early ischaemic stroke: a randomized controlled trial
    Fozia S Nazir
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Cerebrovasc Dis 19:77-83. 2005
    ..We have investigated the effect of the angiotensin-converting enzyme inhibitor perindopril on blood pressure, global and focal cerebral blood flow (CBF) and glomerular filtration rate (GFR) in a ..
  66. ncbi Optimized and validated initial-rate method for the determination of perindopril erbumine in tablets
    Nafisur Rahman
    Analytical Research Division, Department of Chemistry, Aligarh Muslim University, India
    Chem Pharm Bull (Tokyo) 54:33-6. 2006
    A simple and sensitive kinetic spectrophotometric method for the determination of perindopril in pharmaceutical preparations is described...
  67. ncbi Effects of the end point adjudication process on the results of the Perindopril Protection Against Recurrent Stroke Study (PROGRESS)
    Toshiharu Ninomiya
    The George Institute for International Health, University of Sydney, Sydney, Australia
    Stroke 40:2111-5. 2009
    ..End point adjudication committees (EPAC) are widely used in large-scale clinical trials to ensure the robustness of diagnosis for end points...
  68. ncbi The rationale and design of the PERindopril GENEtic association study (PERGENE): a pharmacogenetic analysis of angiotensin-converting enzyme inhibitor therapy in patients with stable coronary artery disease
    J J Brugts
    Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Cardiovasc Drugs Ther 23:171-81. 2009
    ..Until now, pharmacogenetic research of the efficacy of ACE-inhibitor therapy in CAD patients is still in a preliminary stage...
  69. ncbi Effects of blood pressure lowering on cerebral white matter hyperintensities in patients with stroke: the PROGRESS (Perindopril Protection Against Recurrent Stroke Study) Magnetic Resonance Imaging Substudy
    Carole Dufouil
    INSERM U708, Paris, France
    Circulation 112:1644-50. 2005
    ..We report here the results of an MRI substudy of PROGRESS (Perindopril Protection Against Recurrent Stroke Study), a randomized trial of blood pressure lowering in subjects with ..
  70. ncbi The cardioprotective effects of the angiotensin-converting enzyme inhibitor perindopril in patients with stable coronary artery disease are not modified by mild to moderate renal insufficiency: insights from the EUROPA trial
    Jasper J Brugts
    Department of Cardiology, Thoraxcenter Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Coll Cardiol 50:2148-55. 2007
    This study sought to examine whether the cardioprotective effects of angiotensin-converting enzyme (ACE) inhibitor therapy by perindopril are modified by renal function in patients with stable coronary artery disease.
  71. ncbi Angiotensin-converting enzyme inhibition in cardiovascular disease: evidence with perindopril
    Roberto Ferrari
    University of Ferrara, Department of Cardiology, Arcispedale S Anna, Corso Giovecca 203, 44100 Ferrara, Italy
    Expert Rev Cardiovasc Ther 3:15-29. 2005
    b>Perindopril is a long-acting, once-daily lipophilic angiotensin-converting enzyme inhibitor with high tissue angiotensin-converting enzyme affinity, lowering angiotensin II and potentiating bradykinin...
  72. ncbi Secondary prevention of coronary disease with ACE inhibition--does blood pressure reduction with perindopril explain the benefits in EUROPA?
    Willem J Remme
    Sticares Cardiovascular Research Institute, Rhoon, The Netherlands
    Cardiovasc Drugs Ther 23:161-70. 2009
    We determined whether blood pressure (BP) lowering by perindopril was related to its benefit in the EUROPA study.
  73. ncbi Double-blind, randomized, multicentre comparison of the effects of amlodipine and perindopril on 24 h therapeutic coverage and beyond in patients with mild to moderate hypertension. General Physicians Investigators' Group
    F Zannad
    Centre d Investigation Clinique de Nancy, INSERM Centre Hospitalier Universitaire, Nancy, France
    J Hypertens 17:137-46. 1999
    To compare the therapeutic coverage and safety of amlodipine and perindopril in patients with mild to moderate hypertension (diastolic blood pressure > or = 90 mmHg and < or = 109 mmHg).
  74. ncbi Molecular mechanism of limbs' postischemic revascularization improved by perindopril in diabetic rats
    Lu Gao
    Hospital of Metabolic Diseases, Tianjin Medical University, Tianjin 300070, China
    Chin Med J (Engl) 121:2129-33. 2008
    ..This study aimed to investigate the reasons of the impaired angiogenesis in the hind limbs of rats with diabetic ischemia, the role and related molecular mechanisms of ACEI in postischemic revascularization...
  75. ncbi Genetic determinants of treatment benefit of the angiotensin-converting enzyme-inhibitor perindopril in patients with stable coronary artery disease
    Jasper Jan Brugts
    Department of Cardiology, Erasmus MC, Thoraxcenter, s Gravendijkwal 230, Rotterdam, The Netherlands
    Eur Heart J 31:1854-64. 2010
    ..However, these patients cannot be identified by clinical characteristics. We developed a genetic profile to predict the treatment benefit of ACE-inhibitors exist and to optimize therapy with ACE-inhibitors...
  76. ncbi Improvement in blood pressure, arterial stiffness and wave reflections with a very-low-dose perindopril/indapamide combination in hypertensive patient: a comparison with atenolol
    R G Asmar
    , Paris, France
    Hypertension 38:922-6. 2001
    ..625 mg) and perindopril (2 mg) (Per/Ind) with the beta-blocking agent atenolol (50 mg) to determine whether Per/Ind decreases SBP and ..
  77. ncbi Long-term angiotensin-converting enzyme inhibitor perindopril therapy improves cerebral perfusion reserve in patients with previous minor stroke
    Jun Hatazawa
    Department of Radiology, Research Institute of Brain and Blood Vessels, Akita, Japan
    Stroke 35:2117-22. 2004
    ..Angiotensin-converting enzyme (ACE) inhibitor-based therapy reduces the recurrence of stroke. The present study assessed the effects of long-term ACE inhibitor therapy on cerebral circulation in patients with previous minor stroke...
  78. ncbi Perindopril preventive treatment on mortality in Duchenne muscular dystrophy: 10 years' follow-up
    Denis Duboc
    Department of Cardiology, Cochin Hospital, APHP, Paris V René Descartes University, Paris, France
    Am Heart J 154:596-602. 2007
    ..data support the efficacy of angiotensin-converting enzyme inhibitors on left ventricular (LV) function, our aim was to examine the long-term impact of a preventive treatment with perindopril on mortality in children with DMD.
  79. ncbi Therapeutic modulation of the nitric oxide: all ace inhibitors are not equivalent
    L Comini
    Cardiovascular Pathophysiology Research Center, Salvatore Maugeri Foundation, IRCCS, Gussago, Brescia, Italy
    Pharmacol Res 56:42-8. 2007
    ..In this experimental study, Sprague-Dawley rats were treated with five different ACE inhibitors (enalapril, perindopril, quinapril, ramipril, and trandolapril) at equihypotensive doses...
  80. ncbi Comparison of trough effect of telmisartan vs perindopril using self blood pressure measurement: EVERESTE study
    S Ragot
    Faculté de Médecine et de Pharmacie et CHU La milétrie, Poitiers, France
    J Hum Hypertens 16:865-73. 2002
    This multicentre study was aimed at comparing the trough effect of telmisartan and perindopril on diastolic blood pressure (DBP), using self blood pressure measurement (SBPM)...
  81. ncbi The prevention of myocardial ultrastructural changes by perindopril, atenolol and amlodipine in chronic alcohol administered rats
    Cemal Sag
    Department of Cardiology, Gulhane Military Medical Academy, Etlik, Ankara, Turkey
    Pharmacol Res 53:142-8. 2006
    The effects of perindopril, an angiotensin converting enzyme inhibitor, atenolol, a beta adrenergic receptor blocker and amlodipine, a calcium channel blocker were investigated in chronic alcohol administered rats...
  82. ncbi Effect of a centrally active angiotensin-converting enzyme inhibitor, perindopril, on cognitive performance in a mouse model of Alzheimer's disease
    Koji Yamada
    Pharmacological Research Laboratories, Research Division, Kyowa Hakko Kirin Co, Ltd, Sunto gun, Shizuoka, Japan
    Brain Res 1352:176-86. 2010
    ..In the present study, we compared the effects of a centrally active ACE inhibitor, perindopril, with those of non-centrally active ACE inhibitors, imidapril and enalapril, on cognitive performance in ..
  83. ncbi Fixed dose combination of perindopril and indapamide improves peripheral vascular function in essential hypertensive patients
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 22:506-12. 2009
    ..on endothelium-dependent and independent vasodilation of 24-week treatment with a fixed-dose combination of perindopril/indapamide (2/0...
  84. ncbi Effects of angiotensin-converting enzyme inhibition with perindopril on left ventricular remodeling and clinical outcome: results of the randomized Perindopril and Remodeling in Elderly with Acute Myocardial Infarction (PREAMI) Study
    Roberto Ferrari
    Department of Cardiology, University of Ferrara, Italy
    Arch Intern Med 166:659-66. 2006
    ..Angiotensin-converting enzyme inhibitors reduce mortality and remodeling after myocardial infarction in patients with left ventricular dysfunction...
  85. ncbi Perindopril, atenolol, and amlodipine prevent aortic ultrastructural changes in rats exposed to ethanol
    Mehmet Yokusoglu
    Department of Cardiology, Gulhane Military Medical School, Etlik, Ankara, Turkey
    Med Sci Monit 14:BR96-102. 2008
    The effects of perindopril, an angiotensin-converting enzyme inhibitor, atenolol, a beta adrenergic receptor blocker, and amlodipine, a calcium channel blocker, were investigated in chronic alcohol administered rats.
  86. ncbi Effect of angiotensin-converting enzyme inhibitor perindopril on interneurons in MPTP-treated mice
    Rumiko Kurosaki
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Eur Neuropsychopharmacol 15:57-67. 2005
    We examined the effects of perindopril on the dopaminergic system in mice after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment. The mice received four intraperitoneal injections of MPTP at 1-h intervals...
  87. ncbi Selective reduction of cardiac mass and central blood pressure on low-dose combination perindopril/indapamide in hypertensive subjects
    Nicola De Luca
    Universita degli Studi Federico II, Naples, Italy
    J Hypertens 22:1623-30. 2004
    ..The objective was to determine whether changes in LVM under drug treatment was preferentially associated with changes in central or brachial SBP and PP...
  88. pmc Ambulatory blood pressure in hypertensive patients with left ventricular hypertrophy: efficacy of first-line combination perindopril/indapamide therapy
    Roland Asmar
    Institut cardiovasculaire, Paris, France
    Vasc Health Risk Manag 3:371-80. 2007
    ..Ambulatory blood pressure (BP) is more sensitive than office BP and is highly correlated with the left ventricular mass (LVM) of hypertensive patients with left ventricular hypertrophy (LVH)...
  89. ncbi Effect of perindopril on coronary remodelling: insights from a multicentre, randomized study
    Gaston A Rodriguez-Granillo
    Department of Interventional Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
    Eur Heart J 28:2326-31. 2007
    This study sought to evaluate the effect of perindopril in coronary remodelling.
  90. ncbi Perindopril alters vascular angiotensin-converting enzyme, AT(1) receptor, and nitric oxide synthase expression in patients with coronary heart disease
    Jia Long Zhuo
    Howard Florey Institute, University of Melbourne, Victoria, Australia
    Hypertension 39:634-8. 2002
    ..We studied the in vivo effects of ACE inhibition with perindopril on cellular expression of ACE, AT(1) receptors and 2 nitric oxide synthase (NOS) isoforms, endothelial (eNOS) ..
  91. ncbi Efficacy of very low dose perindopril 2 mg/indapamide 0.625 mg combination on left ventricular hypertrophy in hypertensive patients: the P.I.C.X.E.L. study rationale and design
    P Gosse
    Service de Cardiologie Hypertension arterielle, Hop Saint André, Bordeaux, France
    J Hum Hypertens 16:653-9. 2002
    The PICXEL study is designed to evaluate the effects of long-term administration of very low-dose combination perindopril 2 mg/indapamide 0...
  92. ncbi The effect of perindopril on cardiovascular morbidity and mortality in patients with diabetes in the EUROPA study: results from the PERSUADE substudy
    Caroline A Daly
    Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Eur Heart J 26:1369-78. 2005
    The aim of this study was to assess the effect of the angiotensin converting enzyme inhibitor perindopril on cardiovascular events in diabetic patients with coronary artery disease.
  93. ncbi Cardiac protective effect of Astragalus on viral myocarditis mice: comparison with Perindopril
    Xiang Jian Chen
    Research Institute of Cardiovascular Disease, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
    Am J Chin Med 34:493-502. 2006
    ..Comparison the myocarditis mice treated with Perindopril (0...
  94. ncbi Prospective randomized study comparing amiodarone vs. amiodarone plus losartan vs. amiodarone plus perindopril for the prevention of atrial fibrillation recurrence in patients with lone paroxysmal atrial fibrillation
    Yuehui Yin
    Department of Cardiology, Second Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400010, China
    Eur Heart J 27:1841-6. 2006
    The purpose of this trial was to compare the long-term efficacy of low-dose amiodarone with losartan and perindopril (both combined with low-dose amiodarone) for the prevention of atrial fibrillation (AF) recurrence in patients with lone ..
  95. ncbi Long-term comparison between perindopril and nifedipine in normotensive patients with type 1 diabetes and microalbuminuria
    G Jerums
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg 3084, Vic, Australia
    Am J Kidney Dis 37:890-9. 2001
    ..Forty-two patients were randomized to treatment with either perindopril, slow-release nifedipine, or placebo...
  96. ncbi The angiotensin-I-converting enzyme inhibitor perindopril suppresses tumor growth and angiogenesis: possible role of the vascular endothelial growth factor
    H Yoshiji
    Third Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara Nara 634 8522, Japan
    Clin Cancer Res 7:1073-8. 2001
    ..Among ACE inhibitors, perindopril appeared to be a potent inhibitor of tumor development and angiogenesis, whereas AT(1)-R antagonists did not ..
  97. ncbi ACE inhibition in hypertension: focus on perindopril
    John R Cockcroft
    Department of Cardiology, Wales Heart Research Institute, Cardiff University, Heath Park, Cardiff, UK
    Am J Cardiovasc Drugs 7:303-17. 2007
    ..In the ASCOT-BPLA trial, antihypertensive therapy based on amlodipine+perindopril significantly reduced total and cardiovascular mortality as well as other clinically relevant outcomes in ..
  98. ncbi Efficacy and tolerability of the perindopril/indapamide combination therapy for hypertension: the PRIMUS study
    Heinrich Holzgreve
    Kardiologische Praxis, Munich, Germany
    Curr Med Res Opin 22:1849-58. 2006
    ..Tight blood pressure (BP) control is required to reduce cardiovascular morbidity and mortality...
  99. ncbi Hypertension in the Very Elderly Trial (HYVET): protocol for the main trial
    C Bulpitt
    Imperial College School of Medicine, Section of Elderly Care, Hammersmith Hospital, London, England
    Drugs Aging 18:151-64. 2001
    ..5mg daily) and additional ACE inhibitor (perindopril) therapy if required...
  100. pmc A review of Perindopril in the reduction of cardiovascular events
    Duncan J Campbell
    St Vincent s Institute of Medical Research and the Department of Medicine, University of Melbourne, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Vasc Health Risk Manag 2:117-24. 2006
    ..More recently, ACEI have been shown to prevent cardiovascular events in individuals with increased cardiovascular risk, where hypertension, left ventricular dysfunction, or heart failure was not the primary indication for ACEI therapy...

Research Grants8

  1. Perindopril-Methamphetamine Interaction Study
    Thomas Newton; Fiscal Year: 2006
    ..b>Perindopril is an FDA-approved antihypertensive medication that has greater activity in the central nervous system than ..
  2. An ACE Inhibitor as a Treatment for Methamphetamine Dependence
    THOMAS FREDERICK NEWTON; Fiscal Year: 2012
    ..R21 DA17182), we conducted a double-blind, placebo-controlled study to evaluate the effects of treatment with perindopril on the subjective and cardiovascular effects of MA in 30 MA-dependent human volunteers...
  3. PREDICTORS OF RECURRENT STROKE IN THE PROGRESS STUDY
    Duncan Campbell; Fiscal Year: 2003
    ..This study is based on plasma samples taken on enrolment from a subset of the 6105 subjects in the perindopril protection against recurrent stroke (PROGRESS) study...
  4. ADVENTITIAL RESPONSE TO VASCULAR INJURY: ESTROGEN
    Suzanne Oparil; Fiscal Year: 2003
    ..These fundamental mechanistic studies will establish more rational strategies for therapeutic intervention in vascular diseases, including the basis for future gene therapy. ..
  5. Estrogen Modulates Injury-Induced Inflammation
    Suzanne Oparil; Fiscal Year: 2007
    ..These fundamental mechanistic studies will enhance our understanding of the pathobiology of vascular disease, particularly as it occurs in aging women, and will provide the basis for development of novel therapeutic strategies. ..
  6. MORPHOLOGY AND FUNCTION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 2006
    ..These studies should provide important new insight into the mechanisms of vascular remodeling. [unreadable] [unreadable] [unreadable]..
  7. Oxidative Stress and Genetics of Prehypertension
    Shawna Nesbitt; Fiscal Year: 2004
    ..abstract_text> ..
  8. Laboratory Models of Cocaine Self-Administration
    Thomas Newton; Fiscal Year: 2008
    ..abstract_text> ..