indomethacin

Summary

Summary: A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.

Top Publications

  1. ncbi Gastroprotective and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats
    Fehmi Odabasoglu
    Ataturk University, Faculty of Pharmacy, Department of Biochemistry, Erzurum, Turkey
    J Ethnopharmacol 103:59-65. 2006
  2. pmc A randomized trial of rectal indomethacin to prevent post-ERCP pancreatitis
    B Joseph Elmunzer
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    N Engl J Med 366:1414-22. 2012
  3. ncbi Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms
    Barbara Schmidt
    Department of Pediatrics, McMaster University, HSC 3N11E, 1200 Main St W, Hamilton, Ontario, Canada L8N 3Z5
    JAMA 289:1124-9. 2003
  4. ncbi A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity
    S Weggen
    Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA
    Nature 414:212-6. 2001
  5. ncbi Protective effect of D-002, a mixture of beeswax alcohols, against indomethacin-induced gastric ulcers and mechanism of action
    Yohani Perez
    Centre of Natural Products, National Centre for Scientific Research, Havana, Cuba
    J Nat Med 67:182-9. 2013
  6. ncbi MRP2 mediated drug-drug interaction: indomethacin increases sulfasalazine absorption in the small intestine, potentially decreasing its colonic targeting
    Arik Dahan
    Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Int J Pharm 386:216-20. 2010
  7. ncbi Differentiation status-dependent regulation of cyclooxygenase-2 expression and prostaglandin E2 production by epidermal growth factor via mitogen-activated protein kinase in articular chondrocytes
    Yun Hyun Huh
    Department of Life Science, National Research Laboratory, Kwangju Institute of Science and Technology, Gwangju 500 712, Korea
    J Biol Chem 278:9691-7. 2003
  8. pmc Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors
    Sandra Holt
    Department of Pharmacology and Clinical Neuroscience, Umea University, Sweden
    Br J Pharmacol 146:467-76. 2005
  9. ncbi Patent ductus arteriosus in micropreemies and full-term infants: the relative merits of surgical ligation versus indomethacin treatment
    Danny C Little
    Scott and White Hospital, Temple, Texas 76508, USA
    J Pediatr Surg 38:492-6. 2003
  10. ncbi Chlorogenic acids from Tithonia diversifolia demonstrate better anti-inflammatory effect than indomethacin and its sesquiterpene lactones
    Daniela Aparecida Chagas-Paula
    Faculdade de Ciências Farmacêuticas de Ribeirão Preto FCFRP, Universidade de Sao Paulo USP, Departamento de Ciências Farmacêuticas Av Café s no, Monte Alegre, 14040 903 Ribeirao Preto, SP, Brazil
    J Ethnopharmacol 136:355-62. 2011

Detail Information

Publications334 found, 100 shown here

  1. ncbi Gastroprotective and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats
    Fehmi Odabasoglu
    Ataturk University, Faculty of Pharmacy, Department of Biochemistry, Erzurum, Turkey
    J Ethnopharmacol 103:59-65. 2006
    ..paper, the gastroprotective effect of usnic acid (UA) isolated from Usnea longissima was investigated in the indomethacin-induced gastric ulcers in rats at doses of 25, 50, 100 and 200 mg/kg body weight...
  2. pmc A randomized trial of rectal indomethacin to prevent post-ERCP pancreatitis
    B Joseph Elmunzer
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    N Engl J Med 366:1414-22. 2012
    ..Preliminary research suggests that rectally administered nonsteroidal antiinflammatory drugs may reduce the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP)...
  3. ncbi Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms
    Barbara Schmidt
    Department of Pediatrics, McMaster University, HSC 3N11E, 1200 Main St W, Hamilton, Ontario, Canada L8N 3Z5
    JAMA 289:1124-9. 2003
    ..Despite more than 2 decades of outcomes research after very preterm birth, clinicians remain uncertain about the extent to which neonatal morbidities predict poor long-term outcomes of extremely low-birth-weight (ELBW) infants...
  4. ncbi A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity
    S Weggen
    Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA
    Nature 414:212-6. 2001
    ..Here we report that the NSAIDs ibuprofen, indomethacin and sulindac sulphide preferentially decrease the highly amyloidogenic Abeta42 peptide (the 42-residue isoform ..
  5. ncbi Protective effect of D-002, a mixture of beeswax alcohols, against indomethacin-induced gastric ulcers and mechanism of action
    Yohani Perez
    Centre of Natural Products, National Centre for Scientific Research, Havana, Cuba
    J Nat Med 67:182-9. 2013
    ..To investigate the gastroprotective effect of D-002 against indomethacin-induced ulcers, oxidative variables and myeloperoxidase (MPO) activity in the rat gastric mucosa were examined...
  6. ncbi MRP2 mediated drug-drug interaction: indomethacin increases sulfasalazine absorption in the small intestine, potentially decreasing its colonic targeting
    Arik Dahan
    Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Int J Pharm 386:216-20. 2010
    ..The purpose of the present study was to evaluate the potential pharmacokinetic interaction between indomethacin and sulfasalazine, in the mechanism of efflux transporter competition...
  7. ncbi Differentiation status-dependent regulation of cyclooxygenase-2 expression and prostaglandin E2 production by epidermal growth factor via mitogen-activated protein kinase in articular chondrocytes
    Yun Hyun Huh
    Department of Life Science, National Research Laboratory, Kwangju Institute of Science and Technology, Gwangju 500 712, Korea
    J Biol Chem 278:9691-7. 2003
    ..Our results indicate that EGF in articular chondrocytes stimulates COX-2 expression and PGE(2) production via ERK and p38 kinase signaling in association with differentiation status...
  8. pmc Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors
    Sandra Holt
    Department of Pharmacology and Clinical Neuroscience, Umea University, Sweden
    Br J Pharmacol 146:467-76. 2005
    ..At the 4 h time point, the ED(50) for URB597 was approximately 0.3 mg kg(-1). Indomethacin (5 mg kg(-1) i.p.) completely prevented the oedema response to carrageenan...
  9. ncbi Patent ductus arteriosus in micropreemies and full-term infants: the relative merits of surgical ligation versus indomethacin treatment
    Danny C Little
    Scott and White Hospital, Temple, Texas 76508, USA
    J Pediatr Surg 38:492-6. 2003
    Treatment of ductus arteriosus is controversial. The merits and timing of ductus ligation versus indomethacin treatment were compared.
  10. ncbi Chlorogenic acids from Tithonia diversifolia demonstrate better anti-inflammatory effect than indomethacin and its sesquiterpene lactones
    Daniela Aparecida Chagas-Paula
    Faculdade de Ciências Farmacêuticas de Ribeirão Preto FCFRP, Universidade de Sao Paulo USP, Departamento de Ciências Farmacêuticas Av Café s no, Monte Alegre, 14040 903 Ribeirao Preto, SP, Brazil
    J Ethnopharmacol 136:355-62. 2011
    ....
  11. ncbi Prevention of heterotopic ossification after spinal cord injury with indomethacin
    K Banovac
    Department of Orthopaedics and Rehabilitation, University of Miami School of Medicine, Miami, Florida 33101, USA
    Spinal Cord 39:370-4. 2001
    ..OBJECTIVES: To determine the effect of indomethacin on the prevention of heterotopic ossification (HO) following spinal cord injury (SCI)...
  12. ncbi Suppression of lung metastasis by aspirin but not indomethacin in an in vivo model of chemically induced hepatocellular carcinoma
    Mitsuru Futakuchi
    Department of Experimental Pathology, Graduate School of Medical Science, Nagoya City University, and Nagoya shi Kohseiin Geriatric Hospital, Nagoya, Japan
    Jpn J Cancer Res 93:1175-81. 2002
    ..5% in diet) and indomethacin (IM, 0...
  13. ncbi Indomethacin, a non-steroidal anti-inflammatory drug, develops gastropathy by inducing reactive oxygen species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa: a novel role of mitochondrial aconitase oxidation
    Pallab Maity
    Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, Jadavpur, Kolkata, West Bengal, India
    J Biol Chem 284:3058-68. 2009
    We have investigated the role of mitochondria on the development of indomethacin (a non-steroidal anti-inflammatory drug)-induced gastric mucosal apoptosis and associated gastropathy in rat...
  14. ncbi Differential protective effects of quercetin, resveratrol, rutin and epigallocatechin gallate against mitochondrial dysfunction induced by indomethacin in Caco-2 cells
    Catalina Carrasco-Pozo
    Laboratory of Microbiology and Probiotics, Institute of Nutrition and Food Technology, University of Chile, Av Macul 5540, Santiago, P O Box 138 11, Chile
    Chem Biol Interact 195:199-205. 2012
    ..rutin, resveratrol and epigallocatechin gallate against the alterations of mitochondrial function induced by indomethacin (INDO) in intestinal epithelial Caco-2 cells, and to address the mechanism involved in such damaging effect by ..
  15. pmc Indomethacin-loaded lipid-core nanocapsules reduce the damage triggered by Aβ1-42 in Alzheimer's disease models
    Andressa Bernardi
    Programa de Pós Graduação em Ciências Farmacêuticas, Porto Alegre, Brazil
    Int J Nanomedicine 7:4927-42. 2012
    ..Here, we investigate the potential protective effect of indomethacin-loaded lipid-core nanocapsules (IndOH-LNCs) against cell damage and neuroinflammation induced by amyloid beta (..
  16. pmc Early surgical ligation versus a conservative approach for management of patent ductus arteriosus that fails to close after indomethacin treatment
    Nami Jhaveri
    Department of Pediatrics, University of California, San Francisco, CA 94143 0544, USA
    J Pediatr 157:381-7, 387.e1. 2010
    ..To examine whether a more conservative approach to treating patent ductus arteriosus (PDA) is associated with an increase or decrease in morbidity compared with an approach involving early PDA ligation...
  17. ncbi Hyperbaric oxygenation ameliorates indomethacin-induced enteropathy in rats by modulating TNF-alpha and IL-1beta production
    Z Yang
    Research Laboratory, Department of Anesthesiology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Dig Dis Sci 51:1426-33. 2006
    The effect of hyperbaric oxygenation (HBO2) was investigated in a rat model of indomethacin-induced enteropathy. Enteropathy was induced by two subcutaneous injections of indomethacin (7.5 mg/kg) 24 hr apart...
  18. ncbi Indomethacin-loaded nanocapsules treatment reduces in vivo glioblastoma growth in a rat glioma model
    Andressa Bernardi
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Cancer Lett 281:53-63. 2009
    ..In the present study, we investigated the effect of indomethacin-loaded nanocapsules in an experimental glioma model...
  19. ncbi Indomethacin and retinoic acid modify mouse intestinal inflammation and fibrosis: a role for SPARC
    Borut Klopcic
    School of Medicine and Pharmacology, University of Western Australia, Fremantle, WA, Australia
    Dig Dis Sci 53:1553-63. 2008
    ..b>Indomethacin induces intestinal fibrosis, while retinoic acid (RA) reduces liver fibrosis...
  20. ncbi Non-steroidal anti-inflammatory drugs inhibit cellular proliferation and upregulate cyclooxygenase-2 protein expression in endometrial cancer cells
    Jingchun Gao
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu 501 1194
    Cancer Sci 95:901-7. 2004
    ..the effects of several non-steroidal anti-inflammatory drugs (NSAIDs), aspirin (acetylsalicylic acid, ASA), indomethacin and a cyclooxygenase-2 (COX-2)-selective inhibitor (NS398), on cellular proliferation and regulation of COX-2 ..
  21. pmc Indomethacin promotes adipogenesis of mesenchymal stem cells through a cyclooxygenase independent mechanism
    Maya Styner
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7170, USA
    J Cell Biochem 111:1042-50. 2010
    ..Here we investigated the role of COX2 and its products during MSC differentiation. Indomethacin stimulated adipogenesis (increased aP2, adiponectin and lipid droplets) of CH310T1/2 stem cells as well as ..
  22. pmc Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats
    Xin Zhang
    Department of Pharmacology, Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, Kyoto 601 8550, Japan
    World J Gastroenterol 14:4784-90. 2008
    To investigate the mucosal protective effect and the mechanisms of action of the anti-ulcer drug irsogladine maleate in gastric injury induced by indomethacin in rats.
  23. ncbi Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer
    N Kundu
    Program in Oncology, University of Maryland Greenebaum Cancer Center and School of Medicine, Baltimore, MD 21201, USA
    Int J Cancer 93:681-6. 2001
    ..in vitro reveals that nearly complete inhibition of prostaglandin synthesis occurs in the presence of either indomethacin, which inhibits both isoforms, or NS398, which is selective for the cox-2 isoform...
  24. ncbi Reactive oxygen species-quenching and anti-apoptotic effect of polaprezinc on indomethacin-induced small intestinal epithelial cell injury
    Tatsushi Omatsu
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto, 602 8566, Japan
    J Gastroenterol 45:692-702. 2010
    ..The aim of this study was to clarify the mechanism by which indomethacin-induced small intestinal mucosal injury occurs, by using a rat intestinal epithelial cell line (RIE-1)...
  25. ncbi Paroxysmal hemicrania: a prospective clinical study of 31 cases
    Elisabetta Cittadini
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Brain 131:1142-55. 2008
    ..Since there is no reliable clinical marker of that response we recommend an indometacin test, either orally or by injection for any patient with lateralized discrete attacks of head pain with associated cranial autonomic symptoms...
  26. pmc Effects of indomethacin-loaded nanocapsules in experimental models of inflammation in rats
    A Bernardi
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, RS, Brazil
    Br J Pharmacol 158:1104-11. 2009
    The effects of systemic treatment with indomethacin-loaded nanocapsules (IndOH-NC) were compared with those of free indomethacin (IndOH) in rat models of acute and chronic oedema.
  27. ncbi An electronic pressure-meter nociception paw test for mice
    T M Cunha
    Departamento de Farmacologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Braz J Med Biol Res 37:401-7. 2004
    ..b>Indomethacin administered intraperitoneally (1...
  28. ncbi Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning
    M B Kadiiska
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 38:711-8. 2005
    ..This is suggested since 8,12-iso-iPF2alpha-VI is also reduced by indomethacin, yet, unlike other isoprostanes and MDA, it is not generated catalytically by the cyclooxygenase...
  29. ncbi Neurogenesis in rats after focal cerebral ischemia is enhanced by indomethacin
    Benjamin D Hoehn
    Department of Neurosurgery, Stanford University, Stanford, CA, USA
    Stroke 36:2718-24. 2005
    ..Newborn cells may participate in repair following ischemic brain injury, but their survival and function may be influenced by inflammation...
  30. ncbi Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
    R Langenbach
    Laboratory of Experimental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cell 83:483-92. 1995
    ..Homozygous Ptgs1 mutant mice survive well, have no gastric pathology, and show less indomethacin-induced gastric ulceration than wild-type mice, even though their gastric prostaglandin E2 levels are about 1% ..
  31. ncbi Prevalence of spontaneous closure of the ductus arteriosus in neonates at a birth weight of 1000 grams or less
    Josh Koch
    Division of Neonatal Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Pediatrics 117:1113-21. 2006
    ..BW (extremely low birth weight [ELBW] neonates) remain unclear, as does the incidence of failure to close with indomethacin. Therefore, we prospectively examined the prevalence, postnatal age, and clinical variables associated with ..
  32. pmc A role for HSP70 in protecting against indomethacin-induced gastric lesions
    Shintaro Suemasu
    Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    J Biol Chem 284:19705-15. 2009
    A major clinical problem encountered with the use of nonsteroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, is gastrointestinal complications...
  33. ncbi Methamphetamine-induced neuroinflammation and neuronal dysfunction in the mice hippocampus: preventive effect of indomethacin
    Joana Gonçalves
    Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine, University of Coimbra, Portugal
    Eur J Neurosci 31:315-26. 2010
    ..an anti-inflammatory drug could prevent or diminish METH-induced neuroinflammation, and we concluded that indomethacin (10 mg/kg; i.p.) prevented METH-induced glia activation and both TNF system and beta III tubulin alterations...
  34. ncbi Brain uptake of nonsteroidal anti-inflammatory drugs: ibuprofen, flurbiprofen, and indomethacin
    Jagan Mohan R Parepally
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, Texas 79106, USA
    Pharm Res 23:873-81. 2006
    To determine the roles of blood-brain barrier (BBB) transport and plasma protein binding in brain uptake of nonsteroidal anti-inflammatory drugs (NSAIDs)-ibuprofen, flurbiprofen, and indomethacin.
  35. ncbi B-type natriuretic peptide concentrations to guide treatment of patent ductus arteriosus
    J T Attridge
    Department of Paediatrics, Division of Neonatology, University of Virginia, Charlottesville, VA 22908, USA
    Arch Dis Child Fetal Neonatal Ed 94:F178-82. 2009
    To determine whether b-type natriuretic peptide (BNP) concentrations can guide treatment of patent ductus arteriosus (PDA) to reduce the number of indomethacin doses without increasing morbidity.
  36. ncbi Functional mechanism underlying COX-2 expression following administration of indomethacin in rat stomachs: importance of gastric hypermotility
    Koji Takeuchi
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Yamashina, Kyoto 607 8414, Japan
    Dig Dis Sci 49:180-7. 2004
    The expression of COX-2 is up-regulated in the rat stomach after administration of indomethacin, and the inhibition of this enzyme may be a key to NSAID-induced gastric damage...
  37. ncbi Interaction between delta-9-tetrahydrocannabinol and indomethacin
    K Green
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912 3400, USA
    Ophthalmic Res 33:217-20. 2001
    The effect of indomethacin on the Delta9-tetrahydrocannabinol (Delta9-THC)-induced fall in rabbit intraocular pressure (IOP) was determined...
  38. ncbi Parenteral indomethacin (the INDOTEST) in cluster headache
    F Antonaci
    Department of Neurological Sciences, Institute of Neurology IRCCS C Mondino, University of Pavia, Pavia, Italy
    Cephalalgia 23:193-6. 2003
    The interval between indomethacin administration and clinical response may be extremely relevant in the assessment of chronic paroxysmal hemicrania (CPH) and other unilateral headache disorders like cluster headache (CH), with which CPH ..
  39. ncbi Cyclooxygenase (COX) inhibitors induce apoptosis in non-small cell lung cancer through cyclooxygenase independent pathways
    José A Sánchez-Alcázar
    Division of Respiratory Medicine, Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham, NG5 1PB, UK
    Lung Cancer 40:33-44. 2003
    ..NS398, a selective COX inhibitor, and indomethacin, a non-selective COX inhibitor, were cytotoxic in both cell lines, independently of their COX-2 expression...
  40. ncbi Biodisposition of PEG-coated lipid microspheres of indomethacin in arthritic rats
    S Palakurthi
    College of Pharmacy, South Dakota State University, Brookings, SD 57007, USA
    Int J Pharm 290:55-62. 2005
    ..5:0.16 by molar ratio. A comparative biodistribution study was conducted between free indomethacin and lipo-indomethacin (LM and S-LM) in the arthritic rats by administering the formulations at a dose ..
  41. ncbi Clinical trial: protective effect of a commercial fish protein hydrolysate against indomethacin (NSAID)-induced small intestinal injury
    T Marchbank
    Centre for Gastroenterology, Institute of Cell and Molecular Science, Barts and the London School of Medicine, Queen Mary University of London, London, UK
    Aliment Pharmacol Ther 28:799-804. 2008
    ..A partially hydrolysed and dried product of pacific whiting fish is marketed as a health food supplement supporting 'intestinal health'...
  42. ncbi Indomethacin and SC236 enhance the cytotoxicity of doxorubicin in human hepatocellular carcinoma cells via inhibiting P-glycoprotein and MRP1 expression
    Cai Guo Ye
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
    Cancer Lett 304:90-6. 2011
    ..In the present study, indomethacin (a NSAID) and SC236 (a COX-2-selective inhibitor) enhanced the cytotoxicity of doxorubicin in the ..
  43. ncbi Mg,Al layered double hydroxides with intercalated indomethacin: synthesis, characterization, and pharmacological study
    M Del Arco
    Departamento de Quimica Inorganica, Universidad de Salamanca, Salamanca, Spain
    J Pharm Sci 93:1649-58. 2004
    ..0 have been prepared with intercalated indomethacin following two routes: reconstruction from a previously calcined Mg(2)Al-CO(3) LDH, and coprecipitation from the ..
  44. ncbi Inhibition of in vivo constriction of fetal ductus arteriosus by endothelin receptor blockade in rats
    Kazuo Momma
    Department of Pediatric Cardiology, The Heart Institute of Japan, Tokyo Women s Medical University, Tokyo, Japan
    Pediatr Res 53:479-85. 2003
    The fetal ductus can be constricted by drugs, including cyclooxygenase inhibitors (indomethacin), nitric oxide synthesis antagonists [N-nitro-L-arginine monomethyl ester (L-NAME)], and glucocorticoid hormones (dexamethasone)...
  45. ncbi Inhibition of cell invasion by indomethacin on glioma cell lines: in vitro study
    Maode Wang
    Department of Neurosurgery, The First Hospital, Xi an Jiaotong University, No 1 Jiankang Road, Xi an, China
    J Neurooncol 72:1-9. 2005
    ..In this study, one of the non-steroidal anti-inflammatory drugs (NSAIDs) indomethacin was employed to investigate the effect of inhibition of cell invasion mediated by MMP-2 and MMP-9 in human ..
  46. ncbi Molecular mobility and fragility in indomethacin: a thermally stimulated depolarization current study
    N T Correia
    , Lisboa, Portugal
    Pharm Res 18:1767-74. 2001
    ..b>Indomethacin (Tg = 42 degrees C) is used as a model compound...
  47. ncbi Oxidative stress involvement and gene expression in indomethacin-induced gastropathy
    Yuji Naito
    Department of Medical Proteomics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Redox Rep 11:243-53. 2006
    ..microvascular injuries are important prime events that lead to gastric mucosal injury induced by indomethacin. Reactive oxygen species (ROS) produced by activated neutrophils after indomethacin treatment cause gastric ..
  48. ncbi Risk factors for persistent ductus arteriosus patency during indomethacin treatment
    Nancy Chorne
    Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, California, USA
    J Pediatr 151:629-34. 2007
    ..To test the hypothesis that patent ductus arteriosus that fail to close with prostaglandin inhibition may be regulated by mechanisms that act independently of prostaglandin production...
  49. ncbi The proapoptotic effects of sulindac, sulindac sulfone and indomethacin are mediated by nucleolar translocation of the RelA(p65) subunit of NF-kappaB
    C J Loveridge
    Colon Cancer Genetics Group, University of Edinburgh Cancer Research Centre, School of Clinical and Molecular Medicine and MRC Human Genetics Unit, Western General Hospital, Edinburgh, Scotland, UK
    Oncogene 27:2648-55. 2008
    ..Here, we demonstrate that sulindac, sulindac sulfone and indomethacin activate the NF-kappaB pathway in colorectal cancer cells, as determined by western blot analysis of ..
  50. ncbi Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants
    B Schmidt
    Department of Pediatrics, McMaster University, Hamilton, Ont, Canada
    N Engl J Med 344:1966-72. 2001
    The prophylactic administration of indomethacin reduces the frequency of patent ductus arteriosus and severe intraventricular hemorrhage in very-low-birth-weight infants (those with birth weights below 1500 g)...
  51. ncbi The effect of vitamin A on contraction of the ductus arteriosus in fetal rat
    G R Wu
    Department of Pediatric Cardiology, The Heart Institute of Japan, Tokyo Women's Medical University, Tokyo, 162 Japan
    Pediatr Res 49:747-54. 2001
    ....
  52. pmc The antiproliferative effect of indomethacin-loaded lipid-core nanocapsules in glioma cells is mediated by cell cycle regulation, differentiation, and the inhibition of survival pathways
    Andressa Bernardi
    Programa de Pós Graduação em Ciências Farmacêuticas, Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, RS, Brasil
    Int J Nanomedicine 8:711-28. 2013
    ..Here, we investigate the mechanisms involved in the antiproliferative effect of indomethacin-loaded lipid-core nanocapsules (IndOH-LNC) in glioma cells...
  53. ncbi TNF-alpha modulates iNOS expression in an experimental rat model of indomethacin-induced jejunoileitis
    Jyotirmoy Nandi
    Division of Gastroenterology, Department of Medicine, State University of New York, Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Mol Cell Biochem 336:17-24. 2010
    ..We evaluated the role of the pro-inflammatory cytokine TNF-alpha on nitric oxide synthase (NOS) expression in indomethacin-induced jejunoileitis in rats...
  54. ncbi Suppression of indomethacin-induced apoptosis in the small intestine due to Bach1 deficiency
    Akihito Harusato
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Free Radic Res 45:717-27. 2011
    ..This study hypothesized that Bach1 plays an important role in the indomethacin-induced apoptosis in the case of small-intestinal mucosal injury...
  55. ncbi Investigation of properties and recrystallisation behaviour of amorphous indomethacin samples prepared by different methods
    Pranav Karmwar
    School of Pharmacy, University of Otago, 18 Frederick Street, Dunedin 9016, New Zealand
    Int J Pharm 417:94-100. 2011
    The aim of this study was to investigate if amorphous indomethacin samples, prepared using different preparation methods, exhibit different structural and kinetic characteristics and if these differences can be correlated to their ..
  56. pmc The anti-inflammatory drug indomethacin alters nanoclustering in synthetic and cell plasma membranes
    Yong Zhou
    Department of Integrative Biology and Pharmacology, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Biol Chem 285:35188-95. 2010
    The nonsteroidal anti-inflammatory drug indomethacin exhibits diverse biological effects, many of which have no clear molecular mechanism. Membrane-bound receptors and enzymes are sensitive to their phospholipid microenvironment...
  57. ncbi Clinical features of unilateral headaches beyond migraine and cluster headache and their response to indomethacin
    Stefan Seidel
    Department of Neurology, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 123:536-41. 2011
    ..We assessed headache characteristics, importance of neuroimaging and response to indomethacin in an unselected series of uncommon unilateral headaches...
  58. pmc Pro-ulcer effects of resveratrol in mice with indomethacin-induced gastric ulcers are reversed by L-arginine
    P Guha
    Department of Biochemistry, Dr B C Roy Post Graduate Institute of Basic Medical Sciences and IPGME and R, Kolkata, India
    Br J Pharmacol 159:726-34. 2010
    ..Resveratrol treatment can also induce endothelial NOS (eNOS) expression. Here, we have attempted to modulate NO production via eNOS in order to alleviate the pro-ulcer effects of resveratrol...
  59. ncbi mTOR signaling is involved in indomethacin and nimesulide suppression of colorectal cancer cell growth via a COX-2 independent pathway
    Yan Jie Zhang
    Department of Digestion, Shanghai Jiaotong University, School of Medicine, Shanghai, China
    Ann Surg Oncol 18:580-8. 2011
    ..Here, we analyzed the effect of indomethacin (Indo, a nonselective COX-2 inhibitor) and nimesulide (Nim, a selective COX-2 inhibitor) on mTOR signaling in ..
  60. ncbi Exacerbation of indomethacin-induced small intestinal injuries in Reg I-knockout mice
    Hiroshi Imaoka
    Dept of Gastroenterology and Hepatology, Shimane Univ, Izumo, Japan
    Am J Physiol Gastrointest Liver Physiol 299:G311-9. 2010
    ..First, to examine the effect of Reg I deficiency on such injuries, indomethacin, a widely used NSAID, was injected subcutaneously into 10-wk-old male Reg I-knockout (Reg I(-/-)) and wild-type ..
  61. ncbi Impact of early malnourishment on the chronic inflammatory response and its implications for the effect of indomethacin on Wistar rats
    Thiago de Oliveira Assis
    Department of Morphology, Federal University of Paraiba, Cidade Universitaria, CEP 58051 900, Joao Pessoa, PB, Brazil
    Br J Nutr 106:845-51. 2011
    ..changes the chronic inflammatory response, so as to study its influence on pharmacological response to indomethacin. Rat offspring of dams fed from the first day of gestation to term or throughout the lactation period received ..
  62. ncbi Indomethacin impairs coronary perfusion in infants with hemodynamically significant ductus arteriosus
    Arvind Sehgal
    Monash Newborn, Monash Children s, Monash Medical Centre, Clayton, Victoria, Australia
    Neonatology 101:20-7. 2012
    ..A haemodynamically significant ductus arteriosus (HSDA) is commonly associated with morbidity in preterm infants...
  63. ncbi The effect of indomethacin on paclitaxel sensitivity and apoptosis in oral squamous carcinoma cells: the role of nuclear factor-κB inhibition
    Emiro E Caicedo-Granados
    Molecular Oncology Program, Department of Otolaryngology, University of Minnesota, Minneapolis, MN 55455, USA
    Arch Otolaryngol Head Neck Surg 137:799-805. 2011
    ..To investigate new strategies to intensify chemosensitivity in head and neck squamous cell carcinoma...
  64. ncbi Simultaneous inhibition of anti-coagulation and inflammation: crystal structure of phospholipase A2 complexed with indomethacin at 1.4 A resolution reveals the presence of the new common ligand-binding site
    Nagendra Singh
    Department of Biophysics, All India Institute of Medical Sciences, New Delhi 110 029, India
    J Mol Recognit 22:437-45. 2009
    ..The binding of non-steroidal anti-inflammatory agent indomethacin at this site blocks both catalytic and anti-coagulant actions of PLA(2)...
  65. ncbi Low-dose indomethacin after ischemic acute kidney injury prevents downregulation of Oat1/3 and improves renal outcome
    R Schneider
    Universitatsklinikum Wurzburg, Medizinische Klinik und Poliklinik I Abt Nephrologie, Wurzburg, Germany
    Am J Physiol Renal Physiol 297:F1614-21. 2009
    ..after renal ischemia and is generated by cyclooxygenases (COX), we investigated the effect of the COX inhibitor indomethacin on expression of Oat1/3 after ischemic acute kidney injury (iAKI)...
  66. ncbi Fetal pulmonary vascular remodeling in a rat model induced by hypoxia and indomethacin
    Xue Feng Xu
    The Children s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, People s Republic of China
    J Matern Fetal Neonatal Med 24:172-82. 2011
    This study sought to determine the effect of combined treatment of hypoxia plus indomethacin on pulmonary vascular remodeling in fetal rats.
  67. ncbi Ocular pharmacokinetics profile of different indomethacin topical formulations
    Claudio Bucolo
    Department of Clinical and Molecular Biomedicine, Section of Pharmacology and Biochemistry, University of Catania, Catania, Italy
    J Ocul Pharmacol Ther 27:571-6. 2011
    This study evaluated the ocular pharmacokinetics of indomethacin following topical administration of two different formulations present in the market.
  68. ncbi Role of endothelial nitric oxide synthase in aggravation of indomethacin-induced gastric damage in adjuvant arthritic rats
    S Kato
    Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto, Japan
    J Physiol Pharmacol 60:147-55. 2009
    The role of nitric oxide synthase (NOS) isozymes in the aggravation of indomethacin-induced gastric damage in adjuvant arthritic rats was investigated...
  69. ncbi Early versus late indomethacin treatment for patent ductus arteriosus in premature infants with respiratory distress syndrome
    B Van Overmeire
    Department of Paediatrics, Division of Neonatology, University Hospital Antwerpen, Antwerpen, Belgium
    J Pediatr 138:205-11. 2001
    OBJECTIVE: To compare efficacy and side effects of early versus late indomethacin treatment for patent ductus arteriosus (PDA) in premature infants...
  70. ncbi How useful are B-type natriuretic peptide measurements for monitoring changes in patent ductus arteriosus shunt magnitude?
    S Chen
    Department of Pediatrics, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0544, USA
    J Perinatol 30:780-5. 2010
    ..Although B-type natriuretic peptide (BNP) concentrations seem to be useful for detecting the presence of patent ductus arteriosus, there is no information about their usefulness for monitoring changes in PDA shunt magnitude...
  71. ncbi The effect of quercetin-3-O-β-D-glucuronopyranoside on indomethacin-induced gastric damage in rats via induction of mucus secretion and down-regulation of ICAM-1 expression
    Xiang Mei Yan
    College of Pharmacy, Chung Ang University, Seoul 156 756, Korea
    Arch Pharm Res 34:1527-34. 2011
    ..of the protective effect of quercetin-3-O-β-D-glucuronopyranoside (QGC) from the leaves of Rumex aqauticus on indomethacin (IND, a representative NSAID)-induced gastric damage in rats was investigated...
  72. ncbi Cyclooxygenase inhibitors decrease the growth and induce regression of human esophageal adenocarcinoma xenografts in nude mice
    Sonia Santander
    Aragón Health Research Institute IIS Aragón, University of Zaragoza School of Medicine, Department of Pharmacology and Physiology, C Domingo Miral s n, 50009 Zaragoza, Spain
    Int J Oncol 40:527-34. 2012
    ..were implanted in the flanks of new mice that were randomized to different treatments (6 animals per group): indomethacin (3 mg/kg/day), parecoxib (0.11 and 0...
  73. ncbi Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta
    Machha Ajay
    Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Life Sci 74:603-12. 2003
    ..in part the release of nitric oxide and prostaglandins from the endothelium as pretreatment with L-NAME and indomethacin attenuated the responses...
  74. ncbi Gastroprotective effects of honey and glucose-fructose-sucrose-maltose mixture against ethanol-, indomethacin-, and acidified aspirin-induced lesions in the rat
    Kamel Gharzouli
    Exp Toxicol Pathol 54:217-21. 2002
    ..and of a glucose-fructose-sucrose-maltose mixture (GFSM) was evaluated in the rat using absolute ethanol, indomethacin and acidified acetylsalicylic acid (ASA-HCl) as necrotising agents. Prior gastric administration of honey (2...
  75. ncbi Understanding intestinal vulnerability to perforation in the extremely low birth weight infant
    Phillip V Gordon
    Department of Pediatrics, Ochsner Health System, New Orleans, Louisiana, 70121, USA
    Pediatr Res 65:138-44. 2009
    ..Associations include extreme prematurity, early postnatal steroids (EPS), early use of indomethacin (EUI), and two common pathogens (Candida and Staphylococcus epidermis)...
  76. ncbi Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers
    Halis Suleyman
    Faculty of Medicine, Department of Pharmacology, Ataturk University, Erzurum, Turkey
    Inflammation 33:224-34. 2010
    b>Indomethacin is an indol derivative, non-steroidal, anti-inflammatory drug with anti-inflammatory, analgesic, and antipyretic effects...
  77. ncbi Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice
    Y Ikeda
    Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
    Life Sci 69:2911-9. 2001
    ..On the other hand, indomethacin further significantly suppressed the writhing number of the capsaicin-treated animals, suggesting that the acid-..
  78. ncbi Eupatilin with heme oxygenase-1-inducing ability protects cultured feline esophageal epithelial cells from cell damage caused by indomethacin
    Hyun Ju Song
    Department of Pharmacology, College of Pharmacy, Chung Ang University, Korea
    Biol Pharm Bull 32:589-96. 2009
    ..the ability of eupatilin to induce expression of HO-1 and to analyze its cytoprotective effect against indomethacin-induced damage, since NSAID users have a higher risk of esophageal ulcers or esophagitis than non-NSAID users...
  79. ncbi Effect of overuse of the antimigraine combination of indomethacin, prochlorperazine and caffeine (IPC) on the disposition of its components in chronic headache patients
    Anna Ferrari
    Division of Toxicology and Clinical Pharmacology, Headache Centre, University Centre for Adaptive Disorders and Headache, University of Modena and Reggio Emilia, Largo del Pozzo, 71, 41100 Modena, Italy
    Pharmacol Res 54:142-9. 2006
    The combination of indomethacin, prochlorperazine and caffeine (IPC) is one of the most utilized formulations for the treatment of migraine attacks in Italy...
  80. ncbi Hemicrania continua: a clinical study of 39 patients with diagnostic implications
    Elisabetta Cittadini
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK
    Brain 133:1973-86. 2010
    ..Since there is no reliable clinical marker of that response, we recommend an indometacin test, either orally or by injection, for any patient with unilateral pain, with or without cranial autonomic symptoms...
  81. pmc Enhancement of antinociception by coadministration of minocycline and a non-steroidal anti-inflammatory drug indomethacin in naïve mice and murine models of LPS-induced thermal hyperalgesia and monoarthritis
    Ala a Ahmed Abu-Ghefreh
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, P O Box 24923 Safat, 13110 Kuwait
    BMC Musculoskelet Disord 11:276. 2010
    Minocycline and a non-steroidal anti-inflammatory drug (NSAID) indomethacin, have anti-inflammatory activities and are both used in the management of rheumatoid arthritis...
  82. ncbi Endogenous prostaglandin E2 accelerates healing of indomethacin-induced small intestinal lesions through upregulation of vascular endothelial growth factor expression by activation of EP4 receptors
    Koji Takeuchi
    Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan
    J Gastroenterol Hepatol 25:S67-74. 2010
    The effects of an EP4 agonist/antagonist on the healing of lesions produced by indomethacin in the small intestine were examined in rats, especially in relation to the expression of vascular endothelial growth factor (VEGF) and ..
  83. pmc A potential nitrergic mechanism of action for indomethacin, but not of other COX inhibitors: relevance to indomethacin-sensitive headaches
    Oliver Summ
    Headache Group, Department of Neurology, University of California, 1701 Divisadero St, Suite 480, San Francisco, CA 94115, USA
    J Headache Pain 11:477-83. 2010
    ..b>Indomethacin is of particular interest given its very special effect in some primary headaches...
  84. ncbi Indomethacin responsive headache syndromes: chronic paroxysmal hemicrania and Hemicrania continua. How they were discovered and what we have learned since
    O Sjaastad
    Department of Neurology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
    Funct Neurol 25:49-55. 2010
    In the indomethacin responsive headaches (IRHs), chronic paroxysmal hemicrania (CPH) and Hemicrania continua (HC), the indomethacin (INDO) response is swift, absolute, and permanent, with moderate doses...
  85. ncbi Cutting edge: agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2
    Hiroyuki Hirai
    R and D Center, BML, 1361 1 Matoba, Kawagoe, Saitama 350 1101, Japan
    J Immunol 168:981-5. 2002
    b>Indomethacin is a widely used nonsteroidal anti-inflammatory drug and is generally known to exhibit its multiple biological functions by inhibiting cyclooxygenases or activating peroxisome proliferator-activated receptors...
  86. ncbi Cyclooxygenase inhibitors modulate NK activities that control metastatic disease
    Namita Kundu
    Department of Pathology, University of Maryland, 10 S Pine St, Baltimore, MD 21201, USA
    Cancer Immunol Immunother 54:981-7. 2005
    ..We now show that treatment of tumor cells with the nonselective COX-1/COX-2 inhibitor indomethacin or the selective COX-2 inhibitor celecoxib leads to decreased expression of the MHC class I molecules Ld and Kd ..
  87. ncbi Mechanism of the antiulcerogenic effect of Ganoderma lucidum polysaccharides on indomethacin-induced lesions in the rat
    Yihuai Gao
    New Zealand Institute of Natural Medicines, Auckland, New Zealand
    Life Sci 72:731-45. 2002
    ..shown that the polysaccharide fractions isolated from the fruiting bodies of Ganoderma lucidum (GLPS) prevented indomethacin- and acetic acid-induced gastric mucosal lesions in the rat. However, the mechanisms remain unclear...
  88. ncbi Antinociceptive and anti-inflammatory activities of lectin from marine red alga Pterocladiella capillacea
    Luana Maria Castelo Melo Silva
    Departamento de Bioquimica e Biologia Molecular, Universidade Federal do Ceara, Av Mister Hull s n Bloco 907, 60 455 970, Fortaleza, Ceara, Brasil
    Biol Pharm Bull 33:830-5. 2010
    ..microl/intraplantar) or the hot plate test, and were compared to untreated animals or animals pretreated with indomethacin or morphine. PcL (0.9, 8.1 or 72.9 mg/kg, i.v...
  89. ncbi Orengedokuto and berberine improve indomethacin-induced small intestinal injury via adenosine
    Yoko Watanabe-Fukuda
    Department of Anesthesiology, Keio University School of Medicine, Tokyo, Japan
    J Gastroenterol 44:380-9. 2009
    ..that Japanese herbal medicine, Orengedokuto (OGT; Huang-Lian-Jie-Du-Tang in Chinese), protects mice from lethal indomethacin (IND)-induced enteropathy...
  90. ncbi The controversy surrounding indomethacin for tocolysis
    G A Macones
    Department of Obstetrics and Gynecology, the Center for Clinical Epidemiology and Biostatistics, and the Leonard Davis Institute of Health Economics, University of Pennsylvania Health System, Philadelphia 19104 6021, USA
    Am J Obstet Gynecol 184:264-72. 2001
    b>Indomethacin is a prostaglandin synthetase inhibitor sometimes used for tocolysis...
  91. ncbi Ozonized sunflower oil reduces oxidative damage induced by indomethacin in rat gastric mucosa
    Z Zamora
    Laboratory of Biological Assays, Department of Biomedical Research, Ozone Research Center, Havana, Cuba
    Inflamm Res 57:39-43. 2008
    ..potential cytoprotective effects of ozonized sunflower oil (OSO) in the damage of rat gastric mucosa induced by indomethacin and also to elucidate the role of reactive oxygen species (ROS), lipid peroxidation and some constituents of ..
  92. ncbi Protective effects of indomethacin-loaded nanocapsules against oxygen-glucose deprivation in organotypic hippocampal slice cultures: involvement of neuroinflammation
    Andressa Bernardi
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, RS, Brazil
    Neurochem Int 57:629-36. 2010
    ..Here we investigate the neuroprotective effect of indomethacin-loaded nanocapsules (IndOH-NC) in an in vitro model of ischemia...
  93. ncbi In vitro studies on controlled-release cellulose acetate films for local delivery of chlorhexidine, indomethacin, and meloxicam
    Emel Oyku Cetin
    Department of Biopharmaceutics and Pharmacokinetics, School of Pharmacy, Ege University, Izmir, Turkey
    J Clin Periodontol 31:1117-21. 2004
    ..The aim of the present study was to examine the in vitro release profile of chlorhexidine gluconate, indomethacin, and meloxicam from cellulose acetate films.
  94. ncbi Matrix metalloproteinase (MMP)-2 and MMP-9 and their inhibitor, TIMP-1, in human term decidua and fetal membranes: the effect of prostaglandin F(2alpha) and indomethacin
    U Ulug
    Laboratory for Research in Reproductive Sciences, Department of Obstetrics and Gynecology, Ha'Emek Medical Center, Afula, Israel
    Mol Hum Reprod 7:1187-93. 2001
    ..1, 1.0 and 10 microg/ml) or a PG synthesis inhibitor, indomethacin (10(-4)-10(-6) mol/l)...
  95. ncbi Prenatal or postnatal indomethacin exposure and neonatal gut injury associated with isolated intestinal perforation and necrotizing enterocolitis
    R Sharma
    Division of Neonatology, Department of Pediatrics, University of Florida College of Medicine at Jacksonville, 655 West 8th Street, Jacksonville, FL 32209 6511, USA
    J Perinatol 30:786-93. 2010
    To examine the role of indomethacin in neonatal gut injury.
  96. ncbi Modifications produced by indomethacin and L-NAME in the effect of ultralow-dose aspirin on platelet activity in portal hypertension
    Francisco X Eizayaga
    Facultad de Medicina, Universidad Maimónides, Buenos Aires, Argentina
    Pathophysiol Haemost Thromb 35:357-63. 2006
    ..caused by blocking NO production by nitro arginine methyl ester (NAME) and cyclooxygenase (COX) activity with indomethacin. PVL rats and sham-operated controls were treated with placebo, indomethacin or NAME and 30 min thereafter with ..
  97. ncbi Characterization of mechanisms underlying the effects of esomeprazole on the impairment of gastric ulcer healing with addition of NSAID treatment
    R Colucci
    Interdepartmental Centre for Research in Clinical Pharmacology and Experimental Therapeutics, University of Pisa, Pisa, Italy
    Dig Liver Dis 41:395-405. 2009
    ..The efficacy of proton pump inhibitors in patients at high risk of gastrointestinal injury receiving non-steroidal anti-inflammatory drugs is currently debated...
  98. pmc Is surgical ligation of patent ductus arteriosus necessary? The Western Australian experience of conservative management
    J M Brooks
    Women s and Children s Health Service, Western Australia
    Arch Dis Child Fetal Neonatal Ed 90:F235-9. 2005
    ..Geographical isolation meant that ductal ligation was not an option in King Edward Memorial Hospital until recently...
  99. ncbi Lactobacillus rhamnosus GG exacerbates intestinal ulceration in a model of indomethacin-induced enteropathy
    Rasha Kamil
    entre for Paediatric and Adolescent Gastroenterology, Children, Youth and Women s Health Service, 72 King William Road, North Adelaide, South Australia, Australia
    Dig Dis Sci 52:1247-52. 2007
    ..rhamnosus GG (LGG) and Bifidobacterium lactis Bb12 (Bb12) were assessed for their potential to prevent indomethacin-induced ulceration in the small intestine of Sprague-Dawley rats...
  100. ncbi Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies
    Khaled R A Abdellatif
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alta, Canada
    Bioorg Med Chem Lett 19:3014-8. 2009
    ..14a-c), NO-donor moiety is directly attached to the carboxylic acid group of aspirin, indomethacin or ibuprofen were synthesized...
  101. ncbi Recombinant human lactoferrin ingestion attenuates indomethacin-induced enteropathy in vivo in healthy volunteers
    F J Troost
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
    Eur J Clin Nutr 57:1579-85. 2003
    ....

Research Grants65

  1. The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intake
    NILS WG LAMBRECHT; Fiscal Year: 2012
    ..3) Effect of LPS and interleukin-1ss in the presence and absence of indomethacin on (a) nesfatin- 1/NUCB2 concentration and ghrelin/DAG ratios in rat blood plasma and on (b) mRNA and protein ..
  2. GI-Safer Formulation of Indomethacin for use in Preterm Neonates
    UPENDRA K MARATHI; Fiscal Year: 2010
    ..5 kg, include formula feeding and the use of indomethacin, the standard of care to treat and/or prevent the development of Patent Ductus Arteriosus (PDA)...
  3. GI-Safer Formulation of Indomethacin for use in Preterm Neonates
    UPENDRA K MARATHI; Fiscal Year: 2013
    ..5 kg, include formula feeding and the use of indomethacin, the standard of care to treat and/or prevent the development of Patent Ductus Arteriosus (PDA), a condition ..
  4. Targeting Tight Junctions To Treat Mucositis
    FREDERICK GARY TOBACK; Fiscal Year: 2010
    ..protein protect barrier function and structure in human epithelial cell cultures injured by an oxidant, indomethacin, or low-calcium stress...
  5. CAT1920: A Small Molecule Therapeutic for the Treatment of IBD
    MICHAEL ROBERT JIROUSEK; Fiscal Year: 2010
    ..In a preliminary study in an indomethacin-induced rat model of IBD, CAT1920 showed efficacy at doses of 100 and 300 mg/kg...
  6. Impact of Pregnancy on Drug Absorption, Disposition and End Organ Response
    Steve N Caritis; Fiscal Year: 2013
    ..We will administer to these women a cocktail composed of indomethacin and dextromethorphan to evaluate the activity of the cytochrome P450 enzymes once during pregnancy and once ..
  7. Pharmacogenomics of Preterm Birth Prevention and Treatment
    TRACY ANN MANUCK; Fiscal Year: 2013
    ..Although medications such as 17-alpha hydroxyprogesterone caproate (17OHPC) and indomethacin can prevent and arrest SPTB in some women, >50% of women who receive these medications will still deliver ..
  8. Maternal Fetal Medicine Units Network
    George R Saade; Fiscal Year: 2013
    ..b>indomethacin. We accept the RFA's capitation and participatory stipulations and stand ready to continue as productive ..
  9. Rectal Indomethacin to Prevent of Post-ERCP Pancreatitis in High Risk Patients
    Badih Joseph Elmunzer; Fiscal Year: 2012
    ..of establishing a multi-center clinical trial to study the efficacy of prophylactic rectally-administered indomethacin on the incidence of post-ERCP pancreatitis in high risk patients...
  10. Brain Vasodilator Responses in Healthy and Cognitively Impaired Humans
    JILL NICOLE BARNES; Fiscal Year: 2012
    ..prostaglandins explains the reduction in MCA vasodilator responses to CO2 by comparing the effects of indomethacin on CO2-mediated vasodilation in the MCA in the same 3 groups...
  11. NSAID and COX/PG Metabolism and Colorectal Cancer
    Cornelia Ulrich; Fiscal Year: 2009
    ..catalyze the glucuronidation of aspirin and other NSAIDs including ibuprofen, sulindac, sulindac sulfone, and indomethacin, and the effects of polymorphisms on metabolic capacities...
  12. Peripheral FAAH as a target for novel analgesics
    Miguel Garcia-Guzman; Fiscal Year: 2013
    ..with that of clinically used analgesics, including opiates (morphine), non- steroidal anti-inflammatory drugs (indomethacin) and gabapentin. (3) Determine whether URB937 produces side effects similar to those caused by other analgesics...
  13. Indomethacin and delayed umbilical cord clamp for preterm infant IVH
    Peter J Giannone; Fiscal Year: 2013
    ..Only one medical therapy, prophylactic indomethacin during the first 3 days of life, has been shown to prevent or decrease the severity of IVH in preterm infants, ..
  14. Stress-Induced Sickness Behavior during Social Separation
    Michael B Hennessy; Fiscal Year: 2013
    ..of depressive-like behavior and core temperature increase with anti-inflammatory agents (Interleukin-10 and indomethacin) and by determining whether prior separation increases the central cytokine and/or behavioral response to later ..
  15. PC-NSAIDs for Chemoprevention of Colorectal Cancer
    Lenard M Lichtenberger; Fiscal Year: 2013
    ..novel class of phosphatidylcholine (PC)-associated NSAIDs for chemopreventive activity, ibuprofen (IBU- PC) and indomethacin (INDO-PC) that have been documented in preclinical studies and a pilot clinical trial (IBU-PC) to be safer to ..
  16. Determining Therapeutic Efficacy of AGE in AD
    Neelima Chauhan; Fiscal Year: 2005
    ..Aricept/Donezepil, Rivastigmine, Galantamine]; and regulation of inflammation by NSAIDs [Aspirin, Ibuprofen, Indomethacin]; COX-2 inhibitors [Celebrex, Vioxx]...
  17. SURGICAL STUDIES ON METABOLISM OF G. I. HORMONES
    James Thompson; Fiscal Year: 1993
    ..relationships between the gut and pancreatic acinus and note particularly the roles of NT, prostaglandins, and indomethacin. We will use whole animals, isolated pancreas, and dispersed acini...
  18. OBSTETRIC ANESTHESIA: TOCOLYSIS AND HEMORRHAGE
    DAVID CHESTNUT; Fiscal Year: 1993
    ..of uterine and mesenteric arterial smooth muscle to various agonists, with and without MgSO4, endothelium, and indomethacin, will be examined. In vivo studies will use chronically instrumented gravid ewes...
  19. OVULATION--STUDIES USING IN VITRO PERFUSED OVARIES
    Edward Wallach; Fiscal Year: 1992
    ..alpha 2-macroglobulin) as well as prostaglandins (PGF2 alpha, PGI2) and the prostaglandin synthetase inhibitor, indomethacin. The role of the ovarian renin- angiotensin system during the periovulatory interval will be studied using ..
  20. In Vivo Imaging of Leukocyte-Endothelial Dynamics
    William Mathers; Fiscal Year: 2005
    ..prednisolone acetate, a mast cell stabilizer (optipranolol), or an oral nonsteroidal anti-inflammatory drug (indomethacin) on endothelial-leukocyte dynamics in diseases for which each is frequently prescribed...
  21. EXPERIMENTAL MODEL FOR CHORIOAMNIONITIS AND PREMATURITY
    Michael Gravett; Fiscal Year: 2005
    ..potent inhibitors of proinflammatory cytokine production (dexamethasone,IL-10) o prostaglandin production (indomethacin) to ascertain the most effective intervention to down-regulate the cytokine/prostaglandin cascade and ..
  22. OMEGA-3 FATTY ACIDS & HEPATIC LIPID METABOLISM
    David Otto; Fiscal Year: 1990
    ..acid (C22:6 omega-3) in isolated hepatocytes plus or minus insulin (and in some cases plus or minus indomethacin, a prostaglandin synthesis inhibitor)...
  23. IN VIVO INHIBITORS OF OCULAR PROSTAGLANDIN SYNTHESIS
    STEVEN PODOS; Fiscal Year: 1980
    ..Uveitis and mechanical stimulation of the eye are associated with elevation of aqueous humor prostaglandin. Indomethacin or aspirin decreased the response of the eye to paracentesis, mechanical irritation, and compression...
  24. Stent vs. indomethacin for preventing post-ERCP pancreatitis (SVI study)
    Badih Joseph Elmunzer; Fiscal Year: 2013
    ..We recently reported the results of a large-scale randomized controlled trial demonstrating that rectal indomethacin, a non-steroidal anti-inflammatory drug, reduced the risk of pancreatitis after ERCP in high-risk patients, ..
  25. ROLE OF SEROTONIN IN PREGNANCY-RELATED HYPERTENSION
    Carl Weiner; Fiscal Year: 1992
    ..mimic) or leukotriene C4 (the study agents) regardless of pregnancy status? Question 2: Does pretreatment with indomethacin alter the interaction between serotonin and the study agents regardless of pregnancy status? Question 3: Does a ..
  26. SEROTONIN AND EICOSANOID INTERACTION IN LUNG VASOMOTION
    WENDELL HOFMAN; Fiscal Year: 1992
    ..degrees of COI induced by three chemically dissimilar cyclooxygenase inhibitors (aspirin, meclofenamate and indomethacin)...
  27. COLLAGEN GENE EXPRESSION IN CHONDROCYTES IN INFLAMMATION
    MARY GOLDRING; Fiscal Year: 1990
    ..associated procollagen mRNA levels when the synthesis of PGE2 which inhibits collagen synthesis, is blocked by indomethacin. In contrast, IL-1 suppresses levels of type II and type IX procollagen mRNAs thereby inducing loss of ..
  28. MOLECULAR MODE OF ACTION OF BACTERIAL ENTEROTOXINS
    JOHNNY PETERSON; Fiscal Year: 1999
    ..Antimetabolites (e.g., actinomycin D and cycloheximide) and nonsteroidal anti-inflammatory drugs (e.g., indomethacin) block both CT- induced secretion and eicosanoid synthesis...
  29. STRETCH CHANGES IN THE RABBIT CERVIX BY PROSTAGLANDIN
    John Conrad; Fiscal Year: 1980
    ..the in vitro addition of the prostaglandins PGE2 PGF2 alpha, PGE1, PGF 2 alpha 16,16 dimethyl ester, urea and indomethacin. We hope to use the non-pregnant and pregnant rabbit as a model in the pursuit of chemical agents that can be ..
  30. OVARIAN STEROIDS AND CALCIUM HOMEOSTASIS
    NEIL BRESLAU; Fiscal Year: 1991
    ..hypoestrogenism on Ca homeostasis, and test the ability of medroxyprogesterone acetate, calcitonin or indomethacin to block bone resorption and/or improve intestinal Ca absorption...
  31. INDOMETHACIN FOR ADJUVANT TOCOLYSIS
    George Macones; Fiscal Year: 2004
    ..In this setting, the most common strategy in the United States is to add indomethacin as adjuvant therapy. Unfortunately, there are no data to support that this strategy will improve outcome...
  32. MYOMETRIAL GAP JUNCTION MODULATION IN PRETERM LABOR
    WILLIAM LARSEN; Fiscal Year: 1990
    ..labor including the ovariectomized rat, and in animals injected with estradiol, RU 486, prostaglandins and indomethacin. Finally, biopsies of preterm and term, non-contracting and contracting human myometrium will be analyzed to ..
  33. PRESERVATION OF THE ISCHEMIC/REPERFUSED MYOCARDIUM
    Michael Hess; Fiscal Year: 1990
    ..scavengers of free radicals (Coenzyme Q-10 and Alpha-tocopherol) or inhibitors of free radical generation (indomethacin and ibuprofen for the cyclooxygenase system and allopurinol for the xanthine oxidase system) will protect ..
  34. H+ NEUTRALIZATION AND C1- HOMEOSTASIS IN GASTRIC MUCOSA
    David Soybel; Fiscal Year: 2002
    ..Third, we will evaluate the effects of ulcerogens such as aspirin or indomethacin on activity and expression of basolateral Cl- transport systems in both surface cells and oxyntic cells...
  35. MOLECULAR MECHANISMS OF ASPIRIN IN CANCER PREVENTION
    Zigang Dong; Fiscal Year: 2001
    ..For Specific Air 2, we will use indomethacin and other NSAIDs, which do not inhibit AP-1 activity and are potent prostaglandin H synthase inhibitors to test ..
  36. STRUCTURE AND MECHANISM OF PROSTAGLANDIN H2 SYNTHASE
    PATRICK LOLL; Fiscal Year: 2002
    ..process is inhibited by nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, naproxen, and indomethacin. The specific aims of the project are: (1) exploration of active site plasticity: structures of PGHS complexed ..
  37. Krabbe disease: Combined therapies for the central and peripheral nervous systems
    David A Wenger; Fiscal Year: 2010
    ..Initially these drugs will include minocycline and Indomethacin. These drugs have been successful in reducing demyelination and in providing neuroprotection in other ..
  38. PREVENTION OF HYPEREMIA & HEMORRHAGE IN NEWBORN BRAIN
    Jan Goddard Finegold; Fiscal Year: 1991
    ..flow measurement plus ultrastructural techniques to evaluate the suggested prophylactic agents phenobarbital, indomethacin, (prostaglandin synthesis inhibitor) atropine, hypocarbia, and two oxygen radical scavengers (vitamin E and ..
  39. INHIBITION OF 3A HSD BY ANTI-INFLAMMATORY DRUGS
    TREVOR PENNING; Fiscal Year: 1991
    ..Methods which permit the placement of bromoacetylating agents in a positional manner around NSAIDS (indomethacin and meclofenamate) and SAIDS are being developed...
  40. Mouse Models for Celiac Disease
    Detlef Schuppan; Fiscal Year: 2007
    ..Oral exposure to gluten and further challenge with indomethacin and/or cytokine modulation is expected to generate models that mimick human cd...
  41. DIHYDRODIOL DEHYDROGENASE & PAH DETOXIFICATION
    TREVOR PENNING; Fiscal Year: 1992
    ..hepatoma cell line (H-4II-e) contains dihydrodiol dehydrogenase that is exquisitely sensitive to inhibition by indomethacin and 6- medroxyprogesterone acetate...
  42. LIPOXYGENASE PRODUCTS IN ACUTE RESPIRATORY FAILURE
    Neil Olson; Fiscal Year: 1992
    ..2) To determine the role of cyclooxygenase products by specific blockade of cyclooxygenase (indomethacin) and thromboxane synthetase (dazoxiben) pathways, thromboxane A2 (TXA2) receptors (SQ 29,548), and by infusion ..
  43. ANTI-INFLAMMATORY THERAPIES NEUROTOXICALLY INDUCED PD
    Ole Isacson; Fiscal Year: 2004
    ..Based on several studies, they hypothesize that a cyclooxygenase (COX) 1 and 2 inhibitor (indomethacin [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1-H-indole-3-acetic acid]) can decrease inflammatory reactions caused ..
  44. Exercise Training and Myocardial K-ATP Channel Function
    RUSSELL MOORE; Fiscal Year: 2007
    ..b>Indomethacin and L-NAME will be used in studies to determine the cellular basis for the hyperemia that was exhibited during ..
  45. INDOMETHACIN FOR ADJUVANT TOCOLYSIS
    George Macones; Fiscal Year: 2005
    ..Research Plan: To use a randomized clinical trial to test the hypothesis that indomethacin, when used for adjuvant tocolysis in preterm labor (i.e...
  46. EARLY DETECTION: HETEROTOPIC OSSIFICATION IN CNS INJURY
    James Mountz; Fiscal Year: 2001
    ..Development of HO can be retarded by indomethacin and disodium etidronate...
  47. PROSTAGLANDIN BIOSYNTHESIS IN LUNG MACROPHAGES
    Wei Hsueh; Fiscal Year: 1980
    ..Inhibition of PG synthesis by indomethacin did not inhibit lysosomal enzyme release, suggesting that PGs are not controlling factors for lysosomal enzyme ..
  48. TRIGGER MECHANISMS OF RECURRENT HERPES KERATITIS
    Joel Sugar; Fiscal Year: 1980
    ..The following agents will be investigated in this model: indomethacin, a prostaglandin synthetase inhibitor both topically and systemically; epinenephrine, topically and ..
  49. Reducing Drug Name Confusion with Better Search Software
    KING LUP LIU; Fiscal Year: 2005
    ..3. To incorporate the merging algorithms into a web-accessible, user-friendly search engine that can be used to support decision making during the drug name approval process. ..
  50. VASOACTIVE DRUGS AND NEONATAL CEREBROVASCULAR REACTIVITY
    DANILYN ANGELES; Fiscal Year: 2004
    ..with her knowledge of basic science strategies to examine the effects of vasoactive pharmaceuticals such as indomethacin, dopamine and dobutamine on neonatal cerebrovascular reactivity...
  51. Biliary and Intestinal Cell Models of Drug Toxicity
    MARY KANZ; Fiscal Year: 2004
    ..Bile from rats treated with the NSAID indomethacin has been reported to injure a rat intestinal cell line in vitro...
  52. LIPID DIET EFFECTS ON COLON TUMOR GROWTH AND METASTASES
    SELWYN BROITMAN; Fiscal Year: 1991
    ..Effects of EFA, EPA, and indomethacin on prostaglandin synthesis and lipid profiles of tumors and tissues is assessed...
  53. PPAR GAMMA AGONISTS FOR THE PREVENTION OF COLON CANCER
    Michael Wargovich; Fiscal Year: 2002
    ..We will test troglitazone, pioglitazone, rosiglitazone, BRL 49653 and the anti-inflammatory NSAIDs, indomethacin and ibuprofen...
  54. PHOSPHOLIPID DERIVED SIGNALS IN COLON EPITHELIAL GROWTH
    FREDERICK DERUBERTIS; Fiscal Year: 1992
    ..By contrast, indomethacin treatment has been reported to suppress tumorigenesis in response to colon carcinogens...
  55. VITAMIN E DEFICIENCY AND FUNCTIONAL STATES OF MEMBRANES
    Abbas Kitabchi; Fiscal Year: 1980
    ..Furthermore, prostaglandin inhibitors such as indomethacin will be used to measure steroidogenesis as well as formation of immunoreactive prostaglandin E1...
  56. Indomethacin and p38 Regulating AP-1 In Heat Shock
    Jacob Locke; Fiscal Year: 2004
    ..cell line, HA-1; (3) OC-14 cells are resistant to the cytotoxicity from hyperthermic radiosensitization; (4) indomethacin inhibits both the increase in AP-1 DNA-binding activity and the resistance to hyperthermic radiosensitization ..
  57. The role of E-cadherin in photocarcinogenesis
    Sabine M Brouxhon; Fiscal Year: 2010
    ..Moreover, since we recently demonstrated that inhibition of PGE2 synthesis by indomethacin in vitro, targeted deletion of EP2 in primary mouse keratinocyte (PMK) cultures or deletion of the EP2 receptor ..
  58. IN VIVO SKELETAL RESPONSE TO MECHANICAL STIMULATION
    Diane Cullen; Fiscal Year: 1999
    ..estrogen-related bone loss, on the bone forming response to mechanical loading, (4) to test the effect of indomethacin, a prostaglandin inhibitor, on the bone formation response to moderate and high bending forces, and (5) to ..
  59. Mentored Patient-Oriented Research Career Development Award
    Naim Maalouf; Fiscal Year: 2009
    ..We will test the ability of indomethacin to reverse the hypercalciuria induced by the LCHP diet, by altering PGE2 production...
  60. Interactions of LPA and prostaglandins in implantation
    Jerold Chun; Fiscal Year: 2010
    ..the phenotype of LPA3- deficient female mice is remarkably similar to that seen in pregnant rats treated with indomethacin or mice deficient for cytosolic phospholipase A2a (cPLA2a), suggesting,a link between prostaglandins (PGs) and ..
  61. IN VIVO MECHANICAL LOADING EARLY RESPONSE GENES
    Diane Cullen; Fiscal Year: 2000
    ..hypotheses to be tested are: (1) in vivo loading changes mRNA levels of up to 7 early response genes that are indomethacin-sensitive and bone-specific; (2) these gene responses are first detectable at 30 minutes after the initial load,..
  62. Preserving Neurogenesis and Cognition with NSAID'S
    Theo Palmer; Fiscal Year: 2006
    ..can be sheltered from these effects by oral administration of the non-steroidal anti-inflammatory drug (NSAID) indomethacin. Pilot studies show that hippocampal function is also normalized by indomethacin and the ease with which ..
  63. CYCLOOXYGENASE-2 AND ALCOHOLIC LIVER DISEASE
    Amin Nanji; Fiscal Year: 2003
    ..A specific Cox-2 inhibitor and a non-specific Cox inhibitor (indomethacin) will be administered to rats fed ethanol intragastrically and their effects on the development of pathological ..
  64. PHYSICIAN SCIENTIST AWARD
    Jeffrey Kern; Fiscal Year: 1990
    ..will evaluate commonly used immunomodulatory drugs (dexamethasone and cyclosporin A), cyclooxygenase (indomethacin) and lipoxygenase (U60) inhibition of arachidonic metabolism...
  65. Inflammatory Modulation of Neural Stem Cell Function
    Theo Palmer; Fiscal Year: 2009
    ..shown that neuroinflammation alone is a potent inhibitor of neurogenesis and that inflammatory blockade with indomethacin, a common non-steroidal anti-inflammatory drug, restores neurogenesis following endotoxin-induced inflammation ..