penicillin g

Summary

Summary: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.

Top Publications

  1. ncbi Antimicrobial susceptibilities of 40 isolates of Bacillus anthracis isolated in Turkey
    Duygu Esel
    Department of Microbiology, Faculty of Medicine, Erciyes University, 38039 Kayseri, Turkey
    Int J Antimicrob Agents 22:70-2. 2003
  2. ncbi Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum
    Marco A van den Berg
    DSM Anti Infectives, PO Box 425, 2600 AK Delft, The Netherlands
    Nat Biotechnol 26:1161-8. 2008
  3. ncbi Comparison of phenotypic and genotypic detection of penicillin G resistance of Staphylococcus aureus isolated from bovine intramammary infection
    M Haveri
    Department of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Helsinki, P O Box 57, FIN 00014 Helsinki, Finland
    Vet Microbiol 106:97-102. 2005
  4. ncbi Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family
    I Tamai
    Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, 920 0934, Japan
    Biochem Biophys Res Commun 273:251-60. 2000
  5. pmc Resolving phenylalanine metabolism sheds light on natural synthesis of penicillin G in Penicillium chrysogenum
    Tânia Veiga
    Industrial Microbiology Section, Department of Biotechnology, Delft University of Technology, Julianalaan 67, Delft, The Netherlands
    Eukaryot Cell 11:238-49. 2012
  6. pmc Impact of velvet complex on transcriptome and penicillin G production in glucose-limited chemostat cultures of a β-lactam high-producing Penicillium chrysogenum strain
    Tânia Veiga
    Department of Biotechnology, Delft University of Technology, Delft, The Netherlands
    OMICS 16:320-33. 2012
  7. ncbi An investigation into the role of surfactants in controlling particle size of polymeric nanocapsules containing penicillin-G in double emulsion
    Sepideh Khoee
    Polymer Chemistry Department, School of Science, University of Tehran, P O Box 14155 6455, Tehran, Iran
    Eur J Med Chem 44:2392-9. 2009
  8. pmc Exploring and dissecting genome-wide gene expression responses of Penicillium chrysogenum to phenylacetic acid consumption and penicillinG production
    Diana M Harris
    Department of Biotechnology, Delft University of Technology, Delft, The Netherlands
    BMC Genomics 10:75. 2009
  9. pmc Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks
    Anouk E Muller
    Medical Centre Haaglanden MCH, Department of Obstetrics and Gynecology, Lijnbaan 32, 2512 VA, The Hague, The Netherlands
    Antimicrob Agents Chemother 51:3720-5. 2007
  10. pmc Bacterial resistance to penicillin G by decreased affinity of penicillin-binding proteins: a mathematical model
    L Temime
    Institut National de la Sante et de la Recherche Medicale, Unité 444, Paris, France
    Emerg Infect Dis 9:411-7. 2003

Detail Information

Publications226 found, 100 shown here

  1. ncbi Antimicrobial susceptibilities of 40 isolates of Bacillus anthracis isolated in Turkey
    Duygu Esel
    Department of Microbiology, Faculty of Medicine, Erciyes University, 38039 Kayseri, Turkey
    Int J Antimicrob Agents 22:70-2. 2003
    Forty clinical isolates of Bacillus anthracis were studied. The MIC(90) values of penicillin G, doxycycline, ciprofloxacin, gatifloxacin, and levofloxacin were 0.016, 0.03, 0.06, 0.06 and 0.12 mg/l, respectively...
  2. ncbi Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum
    Marco A van den Berg
    DSM Anti Infectives, PO Box 425, 2600 AK Delft, The Netherlands
    Nat Biotechnol 26:1161-8. 2008
    ....
  3. ncbi Comparison of phenotypic and genotypic detection of penicillin G resistance of Staphylococcus aureus isolated from bovine intramammary infection
    M Haveri
    Department of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Helsinki, P O Box 57, FIN 00014 Helsinki, Finland
    Vet Microbiol 106:97-102. 2005
    Resistance of Staphylococcus aureus to penicillin G is common among isolates from bovine mastitis. We determined phenotypic resistance to penicillin G for 151 S...
  4. ncbi Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family
    I Tamai
    Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, 920 0934, Japan
    Biochem Biophys Res Commun 273:251-60. 2000
    ..OATP-B, -C, -D and -E exhibited transport activity for [(3)H]estrone-3-sulfate as a common substrate. OATP-C has a high transport activity with broad substrate specificity...
  5. pmc Resolving phenylalanine metabolism sheds light on natural synthesis of penicillin G in Penicillium chrysogenum
    Tânia Veiga
    Industrial Microbiology Section, Department of Biotechnology, Delft University of Technology, Julianalaan 67, Delft, The Netherlands
    Eukaryot Cell 11:238-49. 2012
    The industrial production of penicillin G by Penicillium chrysogenum requires the supplementation of the growth medium with the side chain precursor phenylacetate. The growth of P...
  6. pmc Impact of velvet complex on transcriptome and penicillin G production in glucose-limited chemostat cultures of a β-lactam high-producing Penicillium chrysogenum strain
    Tânia Veiga
    Department of Biotechnology, Delft University of Technology, Delft, The Netherlands
    OMICS 16:320-33. 2012
    ..The correct PcvelA and PclaeA deletion strains revealed a small reduction of penicillin G productivity relative to the reference strain, which is a much smaller reduction than previously reported for ..
  7. ncbi An investigation into the role of surfactants in controlling particle size of polymeric nanocapsules containing penicillin-G in double emulsion
    Sepideh Khoee
    Polymer Chemistry Department, School of Science, University of Tehran, P O Box 14155 6455, Tehran, Iran
    Eur J Med Chem 44:2392-9. 2009
    ..Under optimum formulation conditions, the encapsulation of penicillin-G can reach up to 60% and the burst release can also fall below 45%. In this case, the fact that the nanocapsules have only 130 nm diameter will be important...
  8. pmc Exploring and dissecting genome-wide gene expression responses of Penicillium chrysogenum to phenylacetic acid consumption and penicillinG production
    Diana M Harris
    Department of Biotechnology, Delft University of Technology, Delft, The Netherlands
    BMC Genomics 10:75. 2009
    ..The recent sequencing of Penicillium chrysogenum strain Wisconsin1255-54 and the availability of genomics tools such as DNA-microarray offer new perspective...
  9. pmc Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks
    Anouk E Muller
    Medical Centre Haaglanden MCH, Department of Obstetrics and Gynecology, Lijnbaan 32, 2512 VA, The Hague, The Netherlands
    Antimicrob Agents Chemother 51:3720-5. 2007
    The pharmacokinetics of penicillin G were studied in 20 preterm neonates with a gestational age of less than 32 weeks on day 3 of life by using a population approach performed with the nonlinear mixed effects modeling program NONMEM...
  10. pmc Bacterial resistance to penicillin G by decreased affinity of penicillin-binding proteins: a mathematical model
    L Temime
    Institut National de la Sante et de la Recherche Medicale, Unité 444, Paris, France
    Emerg Infect Dis 9:411-7. 2003
    Streptococcus pneumoniae and Neisseria meningitidis have very similar mechanisms of resistance to penicillin G. Although penicillin resistance is now common in S. pneumoniae, it is still rare in N. meningitidis...
  11. pmc Organic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin G
    Adam L VanWert
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Renal Physiol 293:F1332-41. 2007
    ..Therefore, this investigation was designed to elucidate the in vivo role of Oat3 in the disposition of penicillin G and prototypical substrates using an Oat3 knockout mouse model...
  12. ncbi Effects of penicillin G on morphology and certain physiological parameters of Lactobacillus acidophilus ATCC 4356
    M Khaleghi
    Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran
    J Microbiol Biotechnol 21:822-9. 2011
    ..Therefore, this study investigated the effects of penicillin G (0.015, 0.03, and 0...
  13. pmc Duration of intrapartum prophylaxis and concentration of penicillin G in fetal serum at delivery
    Emma L Barber
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
    Obstet Gynecol 112:265-70. 2008
    Intrapartum penicillin G prophylaxis aims to prevent early-onset group B streptococci (GBS) sepsis by interrupting vertical transmission...
  14. ncbi Analysis of gene expression in penicillin G induced persistence of Chlamydia pneumoniae
    M Di Pietro
    Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy
    J Biol Regul Homeost Agents 26:277-84. 2012
    ..associated with the development of Chlamydial persistence in a cell culture system in the presence of penicillin G. Chlamydia-infected HEp 2 cells were incubated with or without penicillin G for up to 72 hours...
  15. ncbi Promethazine renders Escherichia coli susceptible to penicillin G: real-time measurement of bacterial susceptibility by fluoro-luminometry
    Janne Lehtinen
    Department of Biochemistry and Food Chemistry, University of Turku, Arcanum, Vatselankatu 2, Turku 20014, Finland
    Int J Antimicrob Agents 30:44-51. 2007
    Gram-negative bacteria are resistant to many hydrophobic antibiotics (such as penicillin G) owing to the highly hydrophilic saccharide part of lipopolysaccharide in the cell membrane, whilst most hydrophilic antibiotics (such as ..
  16. pmc Comparison of oral amoxicillin and intravenous benzyl penicillin for community acquired pneumonia in children (PIVOT trial): a multicentre pragmatic randomised controlled equivalence trial
    Maria Atkinson
    Division of Child Health, University of Nottingham, University Hospital Queen s Medical Centre, Nottingham, UK
    Thorax 62:1102-6. 2007
    ..To ascertain whether therapeutic equivalence exists for the treatment of paediatric community acquired pneumonia by the oral and intravenous (IV) routes...
  17. ncbi Quantitative PCR study on the mode of action of oligosaccharide elicitors on penicillin G production by Penicillium chrysogenum
    R Nair
    Applied Biotechnology Research Group, Department of Molecular and Applied Biosciences, University of Westminster, London, UK
    J Appl Microbiol 107:1131-9. 2009
    To investigate the effects of single and multiple additions of the oligosaccharide elicitors, obtained from alginate and locust bean gum, on penicillin G production and the transcript level of penicillin G biosynthetic genes.
  18. ncbi Ceftriaxone compared with sodium penicillin g for treatment of severe leptospirosis
    Thanachai Panaphut
    Department of Medicine, Khon Kaen Hospital, Khon Kaen, Thailand
    Clin Infect Dis 36:1507-13. 2003
    ..was conducted from July 2000 through December 2001 to compare the clinical efficacies of ceftriaxone and sodium penicillin G for the treatment of severe leptospirosis...
  19. ncbi Tobramycin once versus three times daily, given with penicillin G, to febrile neutropenic cancer patients in Norway: a prospective, randomized, multicentre trial
    Dag Torfoss
    Cancer Clinic, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    J Antimicrob Chemother 59:711-7. 2007
    b>Penicillin G with an aminoglycoside is the standard initial empirical treatment in febrile neutropenia in Norway...
  20. ncbi Replacement of asparagine with arginine at the extracellular end of the second transmembrane (M2) region of insect GABA receptors increases sensitivity to penicillin G
    Alastair M Hosie
    Department of Pharmacology, University College, Gower St, London WC1E 6BT, UK
    Invert Neurosci 6:75-9. 2006
    ..The A301S mutation that confers resistance to dieldrin did not significantly affect the antagonism by PCG...
  21. pmc Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis
    Muhamed Kheir Taha
    Neisseria Unit, Institut Pasteur, 28 rue du Dr Roux, Paris, France
    Antimicrob Agents Chemother 51:2784-92. 2007
    Clinical isolates of Neisseria meningitidis with reduced susceptibility to penicillin G (intermediate isolates, Pen(I)) harbor alterations in the penA gene encoding the penicillin binding protein 2 (PBP2)...
  22. ncbi Correlation between alterations of the penicillin-binding protein 2 and modifications of the peptidoglycan structure in Neisseria meningitidis with reduced susceptibility to penicillin G
    Aude Antignac
    Unité des Neisseria and Centre National de Référence des Méningocoques, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 278:31529-35. 2003
    Reduced susceptibility to penicillin G in Neisseria meningitidis is directly correlated with alterations in the penA gene, which encodes the penicillin-binding protein 2 (PBP2)...
  23. ncbi Determination of penicillin G and its degradation products in a penicillin production wastewater treatment plant and the receiving river
    Dong Li
    State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Water Res 42:307-17. 2008
    To investigate the fate of penicillin G (PEN G) in the wastewater from a PEN G production facility and the receiving river, an analytical method was developed for the simultaneous detection of PEN G and five degradation products using ..
  24. ncbi Evaluation of penicillin G potassium troches in the treatment of minor recurrent aphthous ulceration in a Chinese cohort: a randomized, double-blinded, placebo and no-treatment-controlled, multicenter clinical trial
    Yu Zhou
    State Key Laboratory of Oral Disease, West China College of Stomatology, Sichuan University, Sichuan, China
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:561-6. 2010
    The aim of this study was to explore the effectiveness and safety of topical application of 50 mg penicillin G potassium troches in the treatment of minor recurrent aphthous ulcerations (MiRAU) in a Chinese cohort.
  25. ncbi A new biocatalyst: Penicillin G acylase immobilized in sol-gel micro-particles with magnetic properties
    Susana M S A Bernardino
    ESTM Escola Superior de Turismo e Tecnologia do Mar, Instituto Politécnico de Leiria, Peniche, Portugal
    Biotechnol J 4:695-702. 2009
    The present work focuses on the development and basic characterization of a new magnetic biocatalyst, namely penicillin G acylase (PGA), immobilized in sol-gel matrices with magnetic properties, ultimately aimed for application in ..
  26. ncbi Direct extraction of penicillin G and derivatives from aqueous samples using a stoichiometrically imprinted polymer
    Javier L Urraca
    Department of Analytical Chemistry, Faculty of Chemistry, Universidad Complutense de Madrid, E 28040 Madrid, Spain
    Anal Chem 79:695-701. 2007
    A molecularly imprinted polymer (MIP) prepared using penicillin G procaine salt as the template (PENGp) and a stoichiometric quantity of urea-based functional monomer to target the single oxyanionic species in the template molecule has ..
  27. ncbi Chloramphenicol versus benzylpenicillin and gentamicin for the treatment of severe pneumonia in children in Papua New Guinea: a randomised trial
    Trevor Duke
    Department of Paediatrics, Goroka Base Hospital, PO Box 392, Goroka, Papua New Guinea
    Lancet 359:474-80. 2002
    ..We aimed to establish whether the combination of benzylpenicillin and gentamicin or chloramphenicol would be better as first-line treatment in children with severe pneumonia in Papua New Guinea...
  28. ncbi Microbiological and chemical detection of incurred penicillin G, oxytetracycline, enrofloxacin and ciprofloxacin residues in bovine and porcine tissues
    A L Myllyniemi
    Department of Food Microbiology, National Veterinary and Food Research Institute, P O Box 368 Hämeentie 57, 00231 Helsinki, Finland anna liisa
    Food Addit Contam 17:991-1000. 2000
    Incurred penicillin G, oxytetracycline, enrofloxacin and ciprofloxacin residues in bovine and porcine muscle and kidney samples were analysed by microbiological and chemical methods, the former using Bacillus subtilis BGA as a test ..
  29. ncbi Reduction of antibiotic use in the community reduces the rate of colonization with penicillin G-nonsusceptible Streptococcus pneumoniae
    Didier Guillemot
    Centre de Resource en Biostatistiques, Epidémiologie et Pharmacoépidemiologie, Institut Pasteur, Unit 657, INSERM, France
    Clin Infect Dis 41:930-8. 2005
    There is a lack of evidence documenting the impact of optimized antibiotic use on the rates of colonization with penicillin G-nonsusceptible Streptococcus pneumoniae (PNSP) in children...
  30. pmc Formate as an auxiliary substrate for glucose-limited cultivation of Penicillium chrysogenum: impact on penicillin G production and biomass yield
    Diana M Harris
    Delft University of Technology, Department of Biotechnology, Julianalaan 67, Delft, The Netherlands
    Appl Environ Microbiol 73:5020-5. 2007
    ..The present study has investigated whether penicillin G yields on glucose can be enhanced by cofeeding of an auxiliary substrate that acts as an energy source but not ..
  31. ncbi Cytosolic NADPH metabolism in penicillin-G producing and non-producing chemostat cultures of Penicillium chrysogenum
    Roelco J Kleijn
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Metab Eng 9:112-23. 2007
    ..chrysogenum was obtained by comparing the PPP fluxes from the gluconate-tracer experiment to oxidative PPP fluxes derived via metabolic flux analysis, using different assumptions for the stoichiometry of NADPH consumption and production...
  32. ncbi Uptake of phenylacetic acid by two strains of Penicillium chrysogenum
    S H Eriksen
    Department of General Microbiology, Institute of Molecular Biology, University of Copenhagen, Solvgade 83H, DK 1307 K, Copenhagen, Denmark
    Biotechnol Bioeng 60:310-6. 1998
    ..chrysogenum Wisconsin 54-1255. At high concentrations of phenylacetic acid, contribution to uptake by this carrier is minor in comparison to simple diffusion and therefore, of no importance in the industrial production of penicillin...
  33. ncbi Application of metabolic flux analysis for the identification of metabolic bottlenecks in the biosynthesis of penicillin-G
    W M van Gulik
    Delft University of Technology, Kluyver Laboratory for Biotechnology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Biotechnol Bioeng 68:602-18. 2000
    ..This clearly shows that, in penicillin fermentation, possible limitations in primary metabolism reside in the supply/regeneration of cofactors (NADPH) rather than in the supply of carbon precursors...
  34. ncbi A process to produce penicillin G acylase by surface-adhesion fermentation using Mucor griseocyanus to obtain 6-aminopenicillanic acid by penicillin G hydrolysis
    José Luis Martínez-Hernández
    Department of Biotechnology, Chemistry School, Universidad Autonoma de Coahuila, Blvd Venustiano Carranza, Col República, PO Box 252, 25000 Saltillo, Coahuila, Mexico
    Appl Biochem Biotechnol 160:2045-53. 2010
    The production of extracellular and mycelia-associated penicillin G acylase (maPGA) with Mucor griseocyanus H/55.1.1 by surface-adhesion fermentation using Opuntia imbricata, a cactus, as a natural immobilization support was studied...
  35. ncbi Experiences with an identification and quantification program for inhibitor-positive milk samples
    Claudia Kress
    Dairy Sciences, Institute of Veterinary Food Science, Justus Liebig University, Ludwigstr 21, 35390 Giessen, Germany
    Anal Chim Acta 586:275-9. 2007
    ..b>Penicillin G (mostly together with benzylpenicilloyl metabolites) could be identified in 74.6% of all samples...
  36. ncbi Galbanic acid from Ferula szowitsiana enhanced the antibacterial activity of penicillin G and cephalexin against Staphylococcus aureus
    Ahmad Reza Shahverdi
    Department of Pharmaceutical Biotechnology and Medicinal Plant Research Center, Faculty of Pharmacy, Medical Sciences University of Tehran, Tehran 1417614411, Iran
    Biol Pharm Bull 30:1805-7. 2007
    ..this study the enhancement effect of Ferula szowitsiana roots' acetone extract on the antibacterial activity of penicillin G and cephalexin was evaluated against Staphylococcus aureus...
  37. ncbi Synthesis and screening of a molecularly imprinted polymer library targeted for penicillin G
    Josefine Cederfur
    Biomedical Polymer Technology, Section for Cell and Matrix Biology, Department of Cell and Molecular Biology, Biomedical Center, Lund University, SE 221 84 Lund, Sweden
    J Comb Chem 5:67-72. 2003
    ..imprinted polymers (MIPs) was synthesized by radical bulk polymerization using the beta-lactam antibiotic penicillin G as the template...
  38. ncbi Penicillin G-resistant viridans group streptococcal endocarditis and interpretation of the American Heart Association's Guidelines for the Treatment of Infective Endocarditis
    Shigeki Fujitani
    University of California Los Angeles UCLA Affiliated Infectious Diseases Fellowship Training Program, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Clin Infect Dis 46:1064-6. 2008
    ....
  39. ncbi In vitro selection of mutants of Streptococcus pneumoniae resistant to macrolides and linezolid: relationship with susceptibility to penicillin G or macrolides
    H Carsenti-Dellamonica
    Infectious Disease Department, Archet Hospital, route Saint Antoine de Ginestiere, Nice 06202, France
    J Antimicrob Chemother 56:633-42. 2005
    ..To evaluate the rate of acquisition of resistance to linezolid and macrolides in Streptococcus pneumoniae isolates with different levels of susceptibility to penicillin and erythromycin...
  40. ncbi Post-traumatic Streptococcus salivarius meningitis in a child
    Mehmet Arif Aladag
    Department of Neurosurgery, Medical School, Inonu University, Malatya, Turkey
    Pediatr Int 49:112-4. 2007
  41. ncbi Penicillin degradation catalysed by Zn(II) ions in methanol
    Pilar Gutiérrez Navarro
    Department of Physical Chemistry, Faculty of Pharmacy, University of Granada, Granada E 18071, Spain
    Int J Biol Macromol 33:159-66. 2003
    ..of a single intermediate substrate-metal complex (SM), whereas the degradations of amoxicillin, ampicillin and penicillin G occur with the initial formation of two complexes with different stoichiometry, SM and S(2)M, both in ..
  42. ncbi Neisseria meningitidis strains isolated from invasive infections in France (1999-2002): phenotypes and antibiotic susceptibility patterns
    Aude Antignac
    Unité des Neisseria and Centre National de Référence des Méningocoques, Institut Pasteur, Paris, France
    Clin Infect Dis 37:912-20. 2003
    ..Such strains were heterogeneous and accounted for approximately 30% of isolates during this period, warranting continued surveillance of this phenomenon...
  43. ncbi Antimicrobial drug susceptibility of Staphylococcus aureus strains isolated from bovine and ovine mammary glands
    A Pengov
    Institute for Microbiology, Faculty of Veterinary Medicine, 1000 Ljubljana, Gerbiceva 60, Slovenia
    J Dairy Sci 86:3157-63. 2003
    ..Analyzing the results of the MIC endpoints and the zone diameter values, very major errors, according to the error rate bounded method of Metzler and DeHaan, occurred at an error rate of 3.3% for penicillin and 3.8% for ampicillin...
  44. pmc Activity of telithromycin against penicillin-resistant Streptococcus pneumoniae isolates recovered from French children with invasive and noninvasive infections
    Edouard Bingen
    Service de Microbiologie, Hopital Robert Debre, Paris, France
    Antimicrob Agents Chemother 47:2345-7. 2003
    We compared the activities of telithromycin, erythromycin, azithromycin, josamycin, penicillin G, amoxicillin, cefpodoxime, and ceftriaxone against invasive and noninvasive non-penicillin-susceptible Streptococcus pneumoniae isolates ..
  45. ncbi Group A streptococcal pharyngitis and penicillin G
    Gene H Stollerman
    Clin Infect Dis 44:763; author reply 763-4. 2007
  46. ncbi [Survey of nasopharyngeal carriage of Haemophilus influenzae and Streptococcus pneumoniae in infants at day care centers]
    Koichi Hashida
    Department of Otorhinolaryngology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu
    Nihon Jibiinkoka Gakkai Kaiho 109:821-9. 2006
    ..Further prospective studies are needed to determine upper respiratory tract infection in infants at day care centers and to evaluate carriage, epidemiology, and the drug-resistance rates of these pathogens...
  47. ncbi Oral streptococcal strains isolated from odontogenic infections and their susceptibility to antibiotics
    Gabriela Bancescu
    Department of Medical Microbiology, University of Medicine and Pharmacy C Davila Bucharest School of Dental Medicine
    Rev Med Chir Soc Med Nat Iasi 110:1012-5. 2006
    ..at species level using the Rapid ID 32 STREP system and their susceptibility was testing by the Etest, against: penicillin G, ampicillin, erythromycin, clindamycin and tetracycline...
  48. ncbi [Antibiotic sensitivity of Streptococcus pneumoniae in Tunisia: results of a multicenter study (1998-1999)]
    Faouzia Mahjoubi-Rhimi
    Laboratoire de Microbiologie, Hopital d Enfants de Tunis
    Tunis Med 81:167-71. 2003
    ..No vancomycin resistant strain was found. The acquire resistance rates of Streptococcus pneumoniae in Tunisia are worrying, essentially for penicillin and erythomycin. Amoxicillin and cefotaxime have conserved a good activity...
  49. ncbi Leuconostoc species-associated endocarditis
    Jessica A Starr
    Auburn University Harrison School of Pharmacy, Birmingham, Alabama, USA
    Pharmacotherapy 27:766-70. 2007
    ..The patient received an aortic valve replacement and was treated with penicillin G and gentamicin; he experienced no further complications.
  50. ncbi Antimicrobial susceptibility of community-acquired respiratory tract pathogens in North America in 1999-2000: findings of the PROTEKT surveillance study
    Daryl Hoban
    Health Sciences Centre, Winnipeg, Manitoba, Canada
    Diagn Microbiol Infect Dis 45:251-9. 2003
    ..Overall, 21.3% of pneumococci (n = 687) were penicillin G-resistant (Canada, 10.3%; USA, 32.6%). Corresponding rates of erythromycin resistance were 16.3% and 31.5%...
  51. ncbi Postantibiotic and sub-MIC effects of benzylpenicillin against Streptococcus pneumoniae with different susceptibilities for penicillin
    Inga Odenholt
    Antibiotic Research Unit, Department of Infectious Diseases and Clinical Microbiology, University Hospital, Uppsala, Sweden
    Chemotherapy 49:287-93. 2003
    ..The purpose of the study was to examine whether penicillin-susceptible and nonsusceptible strains of Streptococcus pneumoniae exhibited different pharmacodynamic responses to benzylpenicillin...
  52. pmc Total variation in the penA gene of Neisseria meningitidis: correlation between susceptibility to beta-lactam antibiotics and penA gene heterogeneity
    Sara Thulin
    National Reference Laboratory for Pathogenic Neisseria, Department of Clinical Microbiology, Orebro University Hospital, Orebro, Sweden
    Antimicrob Agents Chemother 50:3317-24. 2006
    ..Good correlation between elevated MICs and the presence of penA mosaic structures was found especially for penicillin G and ampicillin. The Pen(i) isolates comprised an MIC of >0...
  53. ncbi Presence of a mutation in ponA1 of Neisseria gonorrhoeae in numerous clinical samples resistant to various beta-lactams and other, structurally unrelated, antimicrobials
    Katsumi Shigemura
    Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Infect Chemother 11:226-30. 2005
    ..gonorrhoeae strains. We measured the MICs of penicillin G, other beta-lactams, and other kinds of antimicrobials against 53 clinical N...
  54. ncbi Antimicrobial resistance of Staphylococcus aureus and oral streptococci strains from high-risk endocarditis patients
    Francisco Carlos Groppo
    Department of Physiological Sciences, Dentistry School of Piracicaba, UNICAMP, Brazil
    Gen Dent 53:410-3. 2005
    ..Of the Staphylcoccus aureus strains, 50% were resistant to ampicillin, 53.3% to amoxicillin, 60.0% to penicillin G, 13.3% to amoxicillin/clavulanate, 20.0% to azithromycin, 27.6% to clarithromycin, 23.3% to erythromycin, 3...
  55. ncbi Antimicrobial susceptibility patterns of Haemophilus influenzae and Streptococcus pneumoniae isolates in a Beirut general university hospital between 2000 and 2004
    Z Daoud
    University of Balamand and Clinical Microbiology Laboratory of the Saint George University Hospital, Beirut, Lebanon
    Clin Microbiol Infect 12:86-90. 2006
    ..Only 40.6-50% of S. pneumoniae isolates were susceptible to penicillin G. Susceptibility to clindamycin and erythromycin decreased from 94.1% and 89...
  56. ncbi Serotype distribution and antibiotic susceptibility of invasive Streptococcus pneumoniae disease isolates from children in Turkey, 2001-2004
    Isik Yalcin
    Department of Paediatrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Eur J Pediatr 165:654-7. 2006
  57. ncbi A rapid screening method for detecting active compounds against erythromycin-resistant bacterial strains of Finnish origin
    K Kreander
    Drug Discovery and Development Technology Center, Faculty of Pharmacy, University of Helsinki, Finland
    Folia Microbiol (Praha) 50:487-93. 2005
    ..The described method is a rapid, homogeneous, cost-effective and easy-to-perform system for screening of new potential antimicrobial agents in drug discovery...
  58. ncbi [Sensitivity to penicillin G of isolates of pneumococci meningitis and therapeutic implication in CHU of Treichville, Abidjan]
    V Edoh
    Laboratoire de Bacteriologie virologie, CHU de Treichville, BP V03 Abidjan, Cote d lvoire
    Bull Soc Pathol Exot 98:9-10. 2005
    To determine the frequency of pneumococci meningitis with reduced sensitivity to penicillin G isolated from cerebrospinal fluid, 539 strains were studied between 1996 to 2000...
  59. ncbi Anti-microbial susceptibility of Streptococcus spp. isolated from bovine mastitis in Argentina
    G Denamiel
    Microbiologia, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Chorroain 280 1427 Buenos Aires, Argentina
    J Vet Med B Infect Dis Vet Public Health 52:125-8. 2005
    The in vitro susceptibility to penicillin G, erythromycin and clindamycin was determined by the disc diffusion test and by E-test for a total of 47 streptococcal strains (three Streptococcus uberis, 36 Streptococcus agalactiae, eight ..
  60. ncbi Subclinical mastitis and antimicrobial susceptibility of Staphylococcus caprae and Staphylococcus epidermidis isolated from two Italian goat herds
    P Moroni
    Department of Animal Pathology, Hygiene, and Veterinary Public Health, University of Milan, Milan 20133, Italy
    J Dairy Sci 88:1694-704. 2005
    ..Amoxicillin and the combination of amoxicillin and clavulanic acid were only slightly less effective. Tetracycline (62.5 microg/mL) and tilmicosin (500 microg/mL) were the least effective treatments for SEPI and SCAP, respectively...
  61. ncbi Mechanisms of macrolide resistance in clinical pneumococcal isolates in a university hospital, Ankara, Turkey
    B Sener
    Hacettepe University Medical Faculty, Dept of Microbiology and Clinical Microbiology, 06100 Ankara, Turkey
    J Chemother 17:31-5. 2005
    ..The minimum inhibitory concentrations (MICs) of penicillin G, erythromycin A and clindamycin were determined by the agar dilution method according to NCCLS guidelines...
  62. pmc Relationship between the original multiply resistant South African isolates of Streptococcus pneumoniae from 1977 to 1978 and contemporary international resistant clones
    Ralf Rene Reinert
    Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital, RWTH, Pauwelsstrasse 30, Aachen, Germany
    J Clin Microbiol 43:6035-41. 2005
    High-level penicillin G-resistant as well as multidrug-resistant Streptococcus pneumoniae isolates were first described in South Africa in 1977...
  63. ncbi [Activity of ertapenem and 19 other antimicrobial agents against beta-lactam-resistant Streptococcus pneumoniae and Haemophilus influenzae respiratory tract isolates]
    Jose Luis Gómez-Garcés
    Servicio de Microbiologia, Hospital de Mostoles, Instituto Madrileño de la Salud, Rio Jucar s n, 28935 Móstoles, Madrid, Spain
    Enferm Infecc Microbiol Clin 23:67-70. 2005
    ..Although, clinically indicated for the treatment of the polymicrobial abdominal infection, other uses are possible, due to the broad spectrum of action of this antimicrobial agent...
  64. ncbi Antibiotic resistance testing of the total implant-associated micro-flora and its pure isolates
    J Karbach
    Department for Oral Surgery, Johannes Gutenberg University Mainz, Mainz, Germany
    Eur J Med Res 12:120-8. 2007
    ..The aim of the present study was to examine antibiotic resistant strains among the implant-associated microorganisms in vitro, first as mixed cultures and again as pure isolates for resistance to one of five antibiotics...
  65. ncbi Antibiotic resistance in Staphylococci isolated from the vaginas of captive female Leontopithecus (Callitrichidae-Primates)
    Walter Lilenbaum
    Department of Microbiology and Parasitology, Universidade Federal Fluminense, Niteroi RJ, Brazil
    Am J Primatol 68:825-31. 2006
    ..from 25 adult lion tamarins, processed to isolate Staphylococcus species, and tested for susceptibility to penicillin G, gentamicin, chloramphenicol, tetracycline, trimethoprim-sulfamethoxazole, streptomycin, ampicillin, and ..
  66. pmc Characterization of Bacillus anthracis-like bacteria isolated from wild great apes from Cote d'Ivoire and Cameroon
    Silke R Klee
    Robert Koch Institut, Centre for Biological Safety 2, Nordufer 20, 13353 Berlin, Germany
    J Bacteriol 188:5333-44. 2006
    ..the following criteria: motility, resistance to the gamma phage, and, for isolates from Cameroon, resistance to penicillin G. A capsule was expressed not only after induction by CO(2) and bicarbonate but also under normal growth ..
  67. ncbi [Moraxella catarrhalis in chronic and relapsing respiratory tract infections in children]
    I K Volkov
    Antibiot Khimioter 49:43-7. 2004
    ..In such patients the bronchoobstructive syndrome was more frequent (46.6%). High frequency of the affection of the upper respiratory tracts in the examined children was stated (62.1%)...
  68. ncbi [Sensitivity surveillance of Streptococcus pneumoniae isolates for several antibiotics in Gifu prefecture (2004)]
    - Working Group of Tokai Anti-biogram study group
    Research Laboratories of Toyama Chemical Co, Ltd
    Jpn J Antibiot 59:137-51. 2006
    ..13 microg/mL for flomoxef, 6.25 microg/mL for cefdinir and cefotiam, 12.5 microg/mL for norfloxacin and minocycline, 25 microg/mL for cefixime, and 100 microg/mL for clarithromycin...
  69. ncbi In vitro antimicrobial and resistance-modifying activities of aqueous crude khat extracts against oral microorganisms
    Nezar Al-hebshi
    Laboratory of Oral Microbiology, Department of Oral Sciences Oral Microbiology, Faculty of Dentistry, University of Bergen, Armauer Hansens Hus, N 5021 Bergen, Norway
    Arch Oral Biol 51:183-8. 2006
    ..To assess antimicrobial activities of aqueous crude khat (Catha edulis) extracts against a panel of oral microorganisms and to test their ability to modify bacterial resistance to tetracycline and penicillin in vitro...
  70. ncbi High-level gentamicin-resistant isolates of oral streptococci and Aerococcus from blood specimens
    Intetsu Kobayashi
    Chemotherapy Division, Mitsubishi Kagaku Bio Clinical Laboratories, Inc, 3 30 1 Shimura, Itabashi ku, Tokyo 174 8555, Japan
    J Infect Chemother 9:21-4. 2003
    ..faecalis, whereas no polymerase chain reaction (PCR) products were obtained in the other two isolates that were tested. The mechanism of gentamicin resistance in these two isolates is unknown...
  71. ncbi Primary actinomycotic endocarditis: a case report and literature review
    Anupop Jitmuang
    Internal Medicine Unit, Nan Hospital, Nan, Thailand
    J Med Assoc Thai 91:931-6. 2008
    ..However the optimal duration of therapy is still unknown. Prognosis is good with early detection and proper management...
  72. pmc Sequencing of Neisseria meningitidis penA gene: the key to success in defining penicillin G breakpoints
    Luisa Arreaza
    Reference Laboratory for Meningococci, National Center of Microbiology, Institute of Health Carlos III, Madrid, Spain
    Antimicrob Agents Chemother 48:358-9. 2004
    Testing of susceptibility to penicillin G by E-test and sequencing of an internal fragment of the penA gene were done for 43 meningococcal strains. Those strains for which the MIC was >/=0.094 micro g/ml showed mosaic alleles, so 0...
  73. pmc Method for estimation of low outer membrane permeability to beta-lactam antibiotics
    Bernard Lakaye
    Laboratoire d Enzymologie and Centre d Ingénierie des Protéines, Universite de Liege, Institut de Chimie, B 4000 Liege, Belgium
    Antimicrob Agents Chemother 46:2901-7. 2002
    ..2 x 10(-9) cm/s). Using these values, the MICs for a beta-lactamase-overproducing strain of E. cloacae were successfully predicted, demonstrating the validity of the method...
  74. ncbi Acute otitis media caused by Streptococcus pneumoniae in children's hospitals between 1994 and 1997
    E R Wald
    University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, PA, USA
    Pediatr Infect Dis J 20:34-9. 2001
    ..Previous antibiotic use remains the most predictive factor for the recovery of isolates resistant to penicillin and ceftriaxone...
  75. ncbi Sensitivity of Borrelia burgdorferi strains isolated in the Czech Republic
    D Janovska
    Centre of Preventive Medicine, Department of Epidemiology, 3rd Medical Faculty, Charles University, Prague, Czech Republic
    Cent Eur J Public Health 9:38-40. 2001
    ..of 5 strains of Borrelia burgdorferi sensu lato, isolated from patients in the Czech Republic, to penicillin G, ceftriaxone, cefotaxime, doxycycline and amoxycillin combined with clavulanic acid by broth macrodilution ..
  76. ncbi Multiple actinomyces brain abscesses: case report
    M S Tsai
    Institute of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan
    J Clin Neurosci 8:183-6. 2001
    ..Using proper therapy to control infection and intracranial pressure is important. A lon g term follow up with frequent computerised tomography evaluation has been conducted and the patient outcome has been successful recovery...
  77. ncbi Practice guidelines for the diagnosis and management of group A streptococcal pharyngitis. Infectious Diseases Society of America
    Alan L Bisno
    Department of Medicine, University of Miami School of Medicine and Veterans Affairs Medical Center, Miami, FL 33125, USA
    Clin Infect Dis 35:113-25. 2002
  78. ncbi [A case of penicillin-resistant pneumococcal meningitis and antibiotic susceptibility of Streptococcus pneumoniae isolated from children]
    K Himi
    Department of Pediatrics, Chiba University School of Medicine
    Kansenshogaku Zasshi 64:725-33. 1990
    ..Minimal inhibitory concentration (MIC) of penicillin G or S. pneumoniae isolated from cerebrospinal fluid and blood was 0.6 micrograms/ml...
  79. ncbi Usefulness of betalactam therapy for community-acquired pneumonia in the era of drug-resistant Streptococcus pneumoniae: a randomized study of amoxicillin-clavulanate and ceftriaxone
    B Roson
    Infectious Disease, Ciutat Sanitària i Universi aria de Bellvitge, University of Barcelona, L Hospitalet de Llobregat, Spain
    Microb Drug Resist 7:85-96. 2001
    ..The use of appropriate betalactams in patients with penumococcal pneumonia and in the overall CAP population, is reliable at the current level of resistance...
  80. pmc Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa
    X Z Li
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Antimicrob Agents Chemother 39:1948-53. 1995
    ..These results support the notion that these proteins contribute to the intrinsic resistance of P. aeruginosa through the multidrug active efflux process...
  81. ncbi [Borrelia burgdorferi Group: in-vitro antibiotic sensitivity]
    Jens Peter Henneberg
    Department of Dermatology, Ludwig Maximilians University, Munchen, Germany
    Orv Hetil 143:1195-8. 2002
    ..Analyses of the antibiotic susceptibility patterns of borreliae may help to understand the causes of such treatment failures and to develop new therapeutic regimens...
  82. ncbi Reducing infections among women undergoing cesarean section in Colombia by means of continuous quality improvement methods
    M Weinberg
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Intern Med 161:2357-65. 2001
    ..04). CONCLUSION: Simple quality improvement methods can be used to optimize obstetric services and improve outcomes of care in resource-limited settings...
  83. pmc [Standardization of the Neisseria meningitidis antibiogram. Detection of strains relatively resistant to penicillin]
    P Nicolas
    , France
    Bull World Health Organ 76:393-400. 1998
    ..Based on our results and literature data on pharmacokinetics, we propose critical concentrations for these various antibiotics as well as critical diameters for chloramphenicol and rifampicin discs...
  84. ncbi [Distribution and characteristics of Bacillus bacteria associated with hydrobionts and the waters of the Peter the Great Bay, Sea of Japan]
    I A Beleneva
    Mikrobiologiia 77:558-65. 2008
    ..In the Bacillus strains obtained, DNase, RNase, phosphatase, elastolytic, chitinase, and agarolytic activity was detected. Bacilli strains with hydrolytic activity occurred in invertebrates more often than in seawater...
  85. ncbi [Anthrax in the era of biowarfare]
    Philippe Bossi
    Service de maladies infectieuses et tropicales Groupe hospitalier Pitié Salpêtrière, Paris
    Presse Med 32:167-73. 2003
    ..The cutaneous and digestive forms are also possible...
  86. ncbi The efficacy of an antibiotic protocol for community-acquired pneumonia
    C J Dobbin
    Royal Prince Alfred Hospital, Sydney, NSW
    Med J Aust 174:333-7. 2001
    ..Treating a patient according to the protocol saved an average of $77.44 in drug costs. CONCLUSION: One year after implementation, our protocol for treating CAP is proving efficacious, although levels of adherence could improve...
  87. ncbi Fulminant liver failure in a child with invasive group A streptococcal infection
    M N Biesel-Desthieux
    Department of Pediatrics and Pediatric Surgery, University Hospital of Geneva, 1211 Geneva 14, Switzerland
    Eur J Pediatr 162:245-7. 2003
    ..On antibiotics, he recovered rapidly without liver transplantation...
  88. ncbi Susceptibility of strains of Streptococcus agalactiae to macrolides and lincosamides, phenotype patterns and resistance genes
    B Aracil
    Servicio de Microbiologia, Hospital de Mostoles, Mostoles, Madrid Servicio, Spain
    Clin Microbiol Infect 8:745-8. 2002
    ..We therefore studied the susceptibility of clinical isolates of S. agalactiae to penicillin G, erythromycin, azithromycin and clindamycin using National Committee for Clinical Laboratory Standards ..
  89. ncbi [Prevalence of antimicrobial resistance among clinical isolates of Streptococcus pneumoniae in a children's hospital]
    A Nakamura
    Division of Infectious Diseases, Chiba Children's Hospital
    Kansenshogaku Zasshi 71:421-9. 1997
    ..Close surveillance of pneumococcal antimicrobial susceptibility including panipenem is necessary...
  90. ncbi Comparative in vitro activity of penicillin G, levofloxacin, moxifloxacin, telithromycin, pristinamycin, quinupristin-dalfopristin and linezolid against ofloxacin-intermediate and -resistant Streptococcus pneumoniae
    I Fredenucci
    Laboratoire de Microbiologie, Centre Hospitalier Lyon Sud, 165 Chemin du Grand Revoyet, 69310 Pierre Benite, France
    Clin Microbiol Infect 8:680-3. 2002
    ..out on 1158 strains of Streptococcus pneumoniae in order to investigate the in vitro bacteriostatic activity of penicillin G, levofloxacin, moxifloxacin, telithromycin, linezolid, pristinamycin and quinupristin-dalfopristin against ..
  91. ncbi Natural antibiotic susceptibility of Proteus spp., with special reference to P. mirabilis and P. penneri strains
    I Stock
    Rheinische Friedrich Wilhelm Universität Bonn, Institut fur Medizinische Mikrobiologie und Immunologie, Pharmazeutische Mikrobiologie, Bonn, Germany
    J Chemother 15:12-26. 2003
    ..P. mirabilis and P. penneri were naturally resistant to penicillin G, oxacillin, all tested macrolides, lincosamides, streptogramins, glycopeptides, rifampicin and fusidic acid...
  92. ncbi Laboratory detection methods for methicillin resistance in coagulase negative Staphylococcus isolated from ophthalmic infections
    Adália Dias Dourado Oliveira
    Departamento de Oftalmologia, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
    Arq Bras Oftalmol 70:667-75. 2007
    ....
  93. ncbi [Identification of anaerobic bacteria isolated from various clinical specimens and determination of antibiotic susceptibilities]
    Metin Dogan
    Karaman Devlet Hastanesi, Mikrobiyoloji Laboratuvari, Karaman
    Mikrobiyol Bul 44:211-9. 2010
    ..b>Penicillin G, clindamycin, cefoxitin, metronidazole, piperacillin/tazobactam and imipenem susceptibility tests were ..
  94. pmc In vitro activity of gemifloxacin (SB 265805) against anaerobes
    E J Goldstein
    R M Alden Research Laboratory, Santa Monica University of California at Los Angeles Medical Center, Santa Monica, California 90404, USA
    Antimicrob Agents Chemother 43:2231-5. 1999
    ..tested included trovafloxacin, levofloxacin, grepafloxacin, sparfloxacin, sitafloxacin (DU-6859a), penicillin G, amoxicillin clavulanate, imipenem, cefoxitin, clindamycin, and metronidazole...
  95. ncbi Tolerability of aztreonam in patients with IgE-mediated hypersensitivity to beta-lactams
    G Patriarca
    Allergy Unit, Policlinico Gemelli, Catholic University of the Sacred Heart, Largo Gemelli 8, Rome, Italy
    Int J Immunopathol Pharmacol 21:375-9. 2008
    ..mixture, semisynthetic penicillins, cephalosporins, aztreonam and imipenem; detection of specific IgE to penicillin G, penicillin V, ampicillin, amoxicillin, cefaclor and ceftriaxone...
  96. ncbi Comparison of antimicrobial in vitro activities against Streptococcus pneumoniae independent of MIC susceptibility breakpoints using MIC frequency distribution curves, scattergrams and linear regression analyses
    R J Fass
    Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA
    J Antimicrob Chemother 48:609-15. 2001
    ..In this study, MICs of penicillin G, ampicillin/sulbactam, ceftriaxone, cefuroxime, erythromycin, tetracycline, trimethoprim/sulfamethoxazole, ..
  97. ncbi Streamlining methodology for the multiresidue analysis of beta-lactam antibiotics in bovine kidney using liquid chromatography-tandem mass spectrometry
    Katerina Mastovska
    US Department of Agriculture, Agricultural Research Service, Eastern Regional Research Center, 600 East Mermaid Lane, Wyndmoor, PA 19038, USA
    J Chromatogr A 1202:118-23. 2008
    ..desfuroylceftiofur cysteine disulfide (DCCD), deacetylcephapirin, dicloxacillin, nafcillin, oxacillin, and penicillin G) in bovine kidney has been further streamlined...
  98. ncbi Antimicrobial resistance of Streptococcus pneumoniae isolated from healthy children in day-care centers: results of a multicenter study in Russia
    L S Stratchounski
    Smolensk State Medical Academy, Russia
    Pediatr Infect Dis J 19:196-200. 2000
    ..healthy children attending day-care centers in Moscow, Smolensk and Yartsevo, Russia, and in vitro activity of penicillin G, amoxicillin/clavulanate, cefaclor, erythromycin, roxithromycin, clarithromycin and trimethoprim-..
  99. ncbi Therapeutic options for pneumococcal pneumonia in Turkey
    Serkan Oncu
    Department of Infectious Diseases and Clinical Microbiology, Adnan Menderes University Medical Faculty, Aydin, Turkey
    Clin Ther 27:674-83. 2005
    ..Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality worldwide. Streptococcus pneumoniae continues to be the most important causative agent in CAP...
  100. ncbi Kinetics of beta-lactam interactions with penicillin-susceptible and -resistant penicillin-binding protein 2x proteins from Streptococcus pneumoniae. Involvement of acylation and deacylation in beta-lactam resistance
    W P Lu
    Anti infective Research, Procter and Gamble Pharmaceuticals, Health Care Research Center, Mason, Ohio 45040, USA
    J Biol Chem 276:31494-501. 2001
    ..These data indicate that the deacylation step also plays a role, which is much more important than previously thought, in PBP2x(R) resistance to beta-lactams...
  101. pmc Molecular epidemiology of clinical and carrier strains of methicillin resistant Staphylococcus aureus (MRSA) in the hospital settings of north India
    Javid A Dar
    Microbiology Division, Institute of Ophthalmology, J, N, Medical College, Aligarh Muslim University, Aligarh, India
    Ann Clin Microbiol Antimicrob 5:22. 2006
    ....

Research Grants19

  1. Functional Consequence of Macrolide Resistance Mutations in T. pallidum
    Sheila A Lukehart; Fiscal Year: 2012
    ..Benzathine penicillin G, used to treat syphilis for the past 50 years, has many disadvantages, including pain at injection sites, the ..
  2. Duration of Intrapartum Antibiotic Prophylaxis for Group B Streptococcus
    Jessica L Illuzzi; Fiscal Year: 2010
    ..Current protocols from the US Centers for Disease Control and Prevention recommend that intrapartum penicillin G prophylaxis be administered at least 4 hours prior to delivery...
  3. Lumbar Puncture and Syphilis Outcome
    Christina M Marra; Fiscal Year: 2013
    ..Treponema pallidum invades the central nervous system (CNS) early in disease, and benzathine penicillin G (BPG), the recommended treatment for uncomplicated syphilis, does not achieve treponemacidal CSF drug levels...
  4. NEW METHODS IN SOLID STATE CRYOENZYMOLOGY
    Jeremy Evans; Fiscal Year: 1990
    ..Initial studies will focus on small molecules (e.g. penicillin G) examined by solid-state NMR spectroscopy under a wide range of conditions...
  5. Enteropathogenic and Toxigenic E.coli Interactions
    JOHN CRANE; Fiscal Year: 2004
    ..abstract_text> ..
  6. Host Cell Killing by EPEC: Central Role in Pathogenesis
    JOHN CRANE; Fiscal Year: 2005
    ..coli (RDEC-1) and rabbit EPEC (REPEC). ..
  7. Trafficking/signaling of P2Y receptors in polarized epithelial cells
    Robert A Nicholas; Fiscal Year: 2011
    ..Our studies will provide novel and important information on the cellular mechanisms of P2Y receptor targeting and the regulation of P2Y receptor signaling activity in epithelial cells. ..
  8. Effect of Zinc in Enteropathogenic E. coli Infection
    JOHN CRANE; Fiscal Year: 2006
    ..abstract_text> ..
  9. GABAa receptor regulation and trafficking in C. elegans
    Bruce Bamber; Fiscal Year: 2003
    ..Because cellular processes are generally well-conserved between C. elegans and humans, insights from these studies could lead to improved treatments for anxiety disorders based on modulating GABAA receptor abundance at synapses. ..
  10. Mechanisms of antibiotic action in Neisseria gonorrhoeae.
    Robert A Nicholas; Fiscal Year: 2010
    ..Together, these projects utilize genetic, biochemical, biophysical, and proteomics approaches to generate new insights into the mechanisms of antibiotic action in N. gonorrhoeae. ..
  11. In Situ Detection of Host-Spirochete Interaction by Iso*
    Ruth Montgomery; Fiscal Year: 2002
    ..burgdorferi. In summary, this proposal employs a novel and powerful technique to address several possible mechanisms of spirochetal evasion of the immune system. ..
  12. REGULATION OF SECRETION FROM HUMAN BASOPHILS
    Donald MacGlashan; Fiscal Year: 2009
    ..A population of subjects will be examined for this relationship. ..
  13. Chemopreventive Activity of Selenium-Derivatives of Celecoxib in Melanoma
    KUMBLE SANDEEP PRABHU; Fiscal Year: 2008
    ..Studies proposed here will be needed to adequately support the specific aims of a large grant application. [unreadable] [unreadable] [unreadable]..
  14. Mechanism of Vector Saliva Inhibition of Innate Immunity
    Ruth Montgomery; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  15. A Zeiss LSM 510 Confocal Microscope for Medical Research
    Ruth Montgomery; Fiscal Year: 2004
    ..Thus this confocal microscope would be the basis of a core facility to assure that these investigators will have adequate access to state-of-the-art imaging techniques. ..
  16. Population-based Surveillance for Zoonotic Influenza A
    Gregory Gray; Fiscal Year: 2005
    ..We are particularly well suited to conduct this work as we have extensive experience conducting both epidemiological and laboratory-based studies of respiratory pathogens. ..
  17. Human Metapneumovirus in High Risk Populations
    Gregory Gray; Fiscal Year: 2005
    ..These data will facilitate the development of more comprehensive epidemiological studies, and guide future intervention studies in reducing HMPV morbidity. ..
  18. MODELS FOR TESTING CANDIDATE TOPICAL MICROBICIDES FOR CYTOTOXICITY AND ACTIVITY A
    Mary Lampe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..