methicillin

Summary

Summary: One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.

Top Publications

  1. pmc Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus
    M C Enright
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, Oxford University, Oxford OX1 3FY
    J Clin Microbiol 38:1008-15. 2000
  2. ncbi Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?
    Jovanka M Voyich
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Infect Dis 194:1761-70. 2006
  3. ncbi The evolution of Staphylococcus aureus
    Ruud H Deurenberg
    Department of Medical Microbiology, University Hospital Maastricht, P Debyelaan 25, 6229 HX Maastricht, The Netherlands
    Infect Genet Evol 8:747-63. 2008
  4. pmc Methicillin-resistant Staphylococcus aureus containing mecC in Swedish dairy cows
    Helle Ericsson Unnerstad
    Department of Animal Health and Antimicrobial Strategies, National Veterinary Institute, Uppsala, SE 751 89, Sweden
    Acta Vet Scand 55:6. 2013
  5. pmc Methicillin-resistant and -susceptible Staphylococcus aureus sequence type 398 in pigs and humans
    Alex van Belkum
    University Medical Center Rotterdam, Rotterdam, The Netherlands
    Emerg Infect Dis 14:479-83. 2008
  6. ncbi SCCmec in staphylococci: genes on the move
    Anne Merethe Hanssen
    Department of Microbiology and Virology, Institute of Medical Biology, University of Tromso, Tromso, Norway
    FEMS Immunol Med Microbiol 46:8-20. 2006
  7. ncbi Review on methicillin-resistant Staphylococcus pseudintermedius
    Engeline van Duijkeren
    Faculty of Veterinary Medicine, Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands
    J Antimicrob Chemother 66:2705-14. 2011
  8. ncbi Three different neutrophil subsets exhibited in mice with different susceptibilities to infection by methicillin-resistant Staphylococcus aureus
    Yasuhiro Tsuda
    Division of Infectious Diseases, Department of Internal Medicine, The University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555, USA
    Immunity 21:215-26. 2004
  9. ncbi Global distribution and evolution of Panton-Valentine leukocidin-positive methicillin-susceptible Staphylococcus aureus, 1981-2007
    Jean Philippe Rasigade
    Universite Lyon 1, Centre National de Référence des Staphylocoques, and Institut National de la Santé et de la Recherche Médicale U851, Institut Fédératif de Recherche 128, Lyon, France
    J Infect Dis 201:1589-97. 2010
  10. pmc Role of ArlRS in autolysis in methicillin-sensitive and methicillin-resistant Staphylococcus aureus strains
    Guido Memmi
    Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire, USA
    J Bacteriol 194:759-67. 2012

Detail Information

Publications318 found, 100 shown here

  1. pmc Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus
    M C Enright
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, Oxford University, Oxford OX1 3FY
    J Clin Microbiol 38:1008-15. 2000
    ..All 22 isolates with the most prevalent allelic profile were methicillin-resistant S...
  2. ncbi Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?
    Jovanka M Voyich
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Infect Dis 194:1761-70. 2006
    b>Methicillin-resistant Staphylococcus aureus (MRSA) remains a major problem in hospitals, and it is now spreading in the community...
  3. ncbi The evolution of Staphylococcus aureus
    Ruud H Deurenberg
    Department of Medical Microbiology, University Hospital Maastricht, P Debyelaan 25, 6229 HX Maastricht, The Netherlands
    Infect Genet Evol 8:747-63. 2008
    ..The adaptive power of S. aureus to antibiotics leaded, in the early 1960s, to the emergence of methicillin-resistant S. aureus (MRSA)...
  4. pmc Methicillin-resistant Staphylococcus aureus containing mecC in Swedish dairy cows
    Helle Ericsson Unnerstad
    Department of Animal Health and Antimicrobial Strategies, National Veterinary Institute, Uppsala, SE 751 89, Sweden
    Acta Vet Scand 55:6. 2013
    Hitherto, methicillin-resistant Staphylococcus aureus (MRSA) has not been detected in Swedish cattle...
  5. pmc Methicillin-resistant and -susceptible Staphylococcus aureus sequence type 398 in pigs and humans
    Alex van Belkum
    University Medical Center Rotterdam, Rotterdam, The Netherlands
    Emerg Infect Dis 14:479-83. 2008
    b>Methicillin-resistant Staphylococcus aureus sequence type 398 (ST398 MRSA) was identified in Dutch pigs and pig farmers. ST398 methicillin-susceptible S. aureus circulates among humans at low frequency (0...
  6. ncbi SCCmec in staphylococci: genes on the move
    Anne Merethe Hanssen
    Department of Microbiology and Virology, Institute of Medical Biology, University of Tromso, Tromso, Norway
    FEMS Immunol Med Microbiol 46:8-20. 2006
    ..cassette chromosome (SCC) elements are, so far, the only vectors described for the mecA gene encoding methicillin resistance in staphylococci...
  7. ncbi Review on methicillin-resistant Staphylococcus pseudintermedius
    Engeline van Duijkeren
    Faculty of Veterinary Medicine, Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands
    J Antimicrob Chemother 66:2705-14. 2011
    ..Since 2006 there has been a significant emergence of methicillin-resistant S. pseudintermedius (MRSP) mainly due to clonal spread...
  8. ncbi Three different neutrophil subsets exhibited in mice with different susceptibilities to infection by methicillin-resistant Staphylococcus aureus
    Yasuhiro Tsuda
    Division of Infectious Diseases, Department of Internal Medicine, The University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555, USA
    Immunity 21:215-26. 2004
    ..PMN-I was obtained from MRSA (methicillin-resistant Staphylococcus aureus)-resistant hosts, while MRSA-sensitive hosts were a source of PMN-II...
  9. ncbi Global distribution and evolution of Panton-Valentine leukocidin-positive methicillin-susceptible Staphylococcus aureus, 1981-2007
    Jean Philippe Rasigade
    Universite Lyon 1, Centre National de Référence des Staphylocoques, and Institut National de la Santé et de la Recherche Médicale U851, Institut Fédératif de Recherche 128, Lyon, France
    J Infect Dis 201:1589-97. 2010
    Panton-Valentine leukocidin (PVL)-positive methicillin-susceptible Staphylococcus aureus and methicillin-resistant S. aureus (MSSA and MRSA, respectively) are both associated with severe infections, such as necrotizing pneumonia...
  10. pmc Role of ArlRS in autolysis in methicillin-sensitive and methicillin-resistant Staphylococcus aureus strains
    Guido Memmi
    Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire, USA
    J Bacteriol 194:759-67. 2012
    ..including ArlRS, a two component regulatory system that has been shown to negatively regulate autolysis in methicillin-sensitive Staphylococcus aureus (MSSA) strains...
  11. ncbi Epidemiology of methicillin-susceptible Staphylococcus aureus lineages in five major African towns: high prevalence of Panton-Valentine leukocidin genes
    S Breurec
    Institut Pasteur, Dakar, Senegal
    Clin Microbiol Infect 17:633-9. 2011
    The epidemiology of methicillin-susceptible Staphylococcus aureus (MSSA) in Africa is poorly documented. From January 2007 to March 2008, 555 S...
  12. pmc Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2
    Patricia Bernal
    School of Pharmacy, University of London, London WC1N 1AX, United Kingdom
    J Biol Chem 285:24055-65. 2010
    Epicatechin gallate (ECg) sensitizes methicillin-resistant Staphylococcus aureus (MRSA) to oxacillin and other beta-lactam agents; it also reduces the secretion of virulence-associated proteins, prevents biofilm formation, and induces ..
  13. pmc Is methicillin-resistant Staphylococcus aureus replacing methicillin-susceptible S. aureus?
    Elizabeth Mostofsky
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    J Antimicrob Chemother 66:2199-214. 2011
    Despite extensive research on the emergence of and treatments for methicillin-resistant Staphylococcus aureus (MRSA), prior studies have not rigorously evaluated the impact of methicillin resistance on the overall incidence of S...
  14. pmc Natural population dynamics and expansion of pathogenic clones of Staphylococcus aureus
    Damian C Melles
    University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, room L 313, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Clin Invest 114:1732-40. 2004
    ..3% of all carriage isolates. Coanalysis of invasive S. aureus strains and epidemic methicillin-resistant S. aureus (MRSA) revealed that all major clusters contained invasive and multiresistant isolates...
  15. ncbi Methicillin-susceptible, non-multiresistant methicillin-resistant and multiresistant methicillin-resistant Staphylococcus aureus infections: a clinical, epidemiological and microbiological comparative study
    W J Munckhof
    Infection Management Service, Princess Alexandra Hospital, Ipswich Rd, Woolloongabba, Brisbane, Queensland, Australia 4102
    Eur J Clin Microbiol Infect Dis 27:355-64. 2008
    Non-multiresistant methicillin-resistant Staphylococcus aureus (nmMRSA) infections are emerging worldwide and are often community-associated...
  16. pmc Incidence, risk factors, and outcomes of Panton-Valentine leukocidin-positive methicillin-susceptible Staphylococcus aureus infections in Auckland, New Zealand
    S Muttaiyah
    Department of Microbiology, Auckland City Hospital, Grafton, Auckland, New Zealand
    J Clin Microbiol 48:3470-4. 2010
    Panton-Valentine leukocidin (PVL) has been linked to invasive community-acquired methicillin-resistant Staphylococcus aureus infections...
  17. pmc Novel multiplex PCR assay for characterization and concomitant subtyping of staphylococcal cassette chromosome mec types I to V in methicillin-resistant Staphylococcus aureus
    Kunyan Zhang
    Centre for Antimicrobial Resistance, Calgary Health Region Calgary Laboratory Services University of Calgary, Calgary, Alberta, Canada T2L 2K8
    J Clin Microbiol 43:5026-33. 2005
    ..cassette chromosome mec (SCCmec) typing is essential for understanding the molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA)...
  18. ncbi Increasing role of Staphylococcus aureus and community-acquired methicillin-resistant Staphylococcus aureus infections in the United States: a 10-year trend of replacement and expansion
    Robertino M Mera
    Research Statistics Unit, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Microb Drug Resist 17:321-8. 2011
    There is the need to properly characterize the temporal trend of U.S. Staphylococcus aureus infections, including methicillin-resistant S. aureus (MRSA) and community-acquired (CA) MRSA in inpatient and outpatient settings.
  19. ncbi Improving methicillin-resistant Staphylococcus aureus surveillance and reporting in intensive care units
    Susan S Huang
    Brigham and Women s Hospital, Channing Laboratory and Infection Control Department, Harvard Medical School, and Harvard Pilgrim Health Care, Boston, MA 02115, USA
    J Infect Dis 195:330-8. 2007
    Routine culturing of patients in intensive care units (ICUs) for methicillin-resistant Staphylococcus aureus (MRSA) identifies unrecognized carriers and facilitates timely isolation...
  20. ncbi The basis for resistance to beta-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus
    Cosimo Fuda
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Biol Chem 279:40802-6. 2004
    ..The strains of S. aureus that have acquired the mecA gene for PBP2a are designated as methicillin-resistant S. aureus (MRSA)...
  21. pmc Occurrence and characterization of methicillin-resistant staphylococci from bovine mastitis milk samples in Finland
    Veera Gindonis
    Faculty of Veterinary Medicine, Department of Production Animal Medicine, University of Helsinki, Koetilantie 7, 00014 Helsinki, Finland
    Acta Vet Scand 55:61. 2013
    b>Methicillin-resistant staphylococci (MRS) are increasingly being isolated in bovine mastitis...
  22. ncbi Are there differences in hospital cost between patients with nosocomial methicillin-resistant Staphylococcus aureus bloodstream infection and those with methicillin-susceptible S. aureus bloodstream infection?
    Debby Ben-David
    Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    Infect Control Hosp Epidemiol 30:453-60. 2009
    To examine the impact of methicillin resistance on in-hospital mortality, length of stay, and hospital cost after the onset of nosocomial Staphylococcus aureus bloodstream infection (BSI).
  23. pmc Methicillin-susceptible Staphylococcus aureus as a predominantly healthcare-associated pathogen: a possible reversal of roles?
    Michael Z David
    Department of Pediatrics, The University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 6:e18217. 2011
    b>Methicillin-resistant Staphylococcus aureus (MRSA) strains have become common causes of skin and soft tissue infections (SSTI) among previously healthy people, a role of methicillin-susceptible (MSSA) isolates before the mid-1990s...
  24. pmc Methicillin-resistant Staphylococcus aureus in poultry
    Davy Persoons
    Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    Emerg Infect Dis 15:452-3. 2009
    b>Methicillin-resistant Staphylococcus aureus (MRSA) has been detected in several species and animal-derived products. To determine whether MRSA is present in poultry, we sampled 50 laying hens and 75 broiler chickens...
  25. ncbi Zinc resistance of Staphylococcus aureus of animal origin is strongly associated with methicillin resistance
    Lina M Cavaco
    Research Group for Antimicrobial Resistance and Molecular Epidemiology, National Food Institute, Technical University of Denmark, Copenhagen, Denmark
    Vet Microbiol 150:344-8. 2011
    This study was conducted to determine the occurrence of zinc and copper resistances in methicillin-resistant Staphylococcus aureus (MRSA) from swine and veal calves in a global strain collection...
  26. ncbi Increased mortality associated with methicillin-resistant Staphylococcus aureus (MRSA) infection in the intensive care unit: results from the EPIC II study
    Håkan Hanberger
    Division of Infectious Diseases, Institution of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Int J Antimicrob Agents 38:331-5. 2011
    ..46 (95% CI 1.03-2.06) (P=0.03). In ICU patients, MRSA infection is therefore independently associated with an almost 50% higher likelihood of hospital death compared with MSSA infection...
  27. pmc In vitro activities of daptomycin-, vancomycin-, and teicoplanin-loaded polymethylmethacrylate against methicillin-susceptible, methicillin-resistant, and vancomycin-intermediate strains of Staphylococcus aureus
    Yuhan Chang
    Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Antimicrob Agents Chemother 55:5480-4. 2011
    ..of polymethylmethacrylate (PMMA) bone cements loaded with daptomycin, vancomycin, and teicoplanin against methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-..
  28. pmc Methicillin-resistant Staphylococcus aureus (MRSA) detected at four U.S. wastewater treatment plants
    Rachel E Rosenberg Goldstein
    Maryland Institute for Applied Environmental Health, University of Maryland School of Public Health, College Park, Maryland 20742, USA
    Environ Health Perspect 120:1551-8. 2012
    The incidence of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections is increasing in the United States, and it is possible that municipal wastewater could be a reservoir of this microorganism...
  29. pmc Methicillin-susceptible ST398 Staphylococcus aureus responsible for bloodstream infections: an emerging human-adapted subclone?
    Anne Sophie Valentin-Domelier
    Service de Bacteriologie et Hygiene, Hopital Trousseau, Centre Hospitalier Universitaire, Tours, France
    PLoS ONE 6:e28369. 2011
    ..0.014 in 2010). ST398 BSI isolates differed from the pig-borne multiresistant clone: 17/18 BSI isolates were methicillin susceptible and none was of t011, t034 or t108 pig-borne spa-types...
  30. pmc Evolution and molecular characterization of methicillin-resistant Staphylococcus aureus epidemic and sporadic clones in Cordoba, Argentina
    Claudia Sola
    Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Argentina
    J Clin Microbiol 44:192-200. 2006
    Since 1999, a new, epidemic, methicillin-resistant Staphylococcus aureus (MRSA) strain, named the "Cordobes clone," has emerged in Argentina and coexists with the pandemic Brazilian clone...
  31. ncbi High-resolution melting analysis of the spa locus reveals significant diversity within sequence type 93 methicillin-resistant Staphylococcus aureus from northern Australia
    S Y C Tong
    Menzies School of Health Research, Institute of Advanced Studies, Charles Darwin University, Darwin, NT, Australia
    Clin Microbiol Infect 15:1126-31. 2009
    ..The data support a very early acquisition, or multiple independent acquisitions, of SCCmec by ST93 methicillin-susceptible S. aureus (MSSA), and the coexistence of MSSA and methicillin-resistant S...
  32. ncbi Multiplex PCR strategy for subtyping the staphylococcal cassette chromosome mec type IV in methicillin-resistant Staphylococcus aureus: 'SCCmec IV multiplex'
    Catarina Milheiriço
    Laboratory of Molecular Genetics, Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal
    J Antimicrob Chemother 60:42-8. 2007
    To develop and validate a new multiplex PCR strategy for subtyping SCCmec type IV methicillin-resistant Staphylococcus aureus (MRSA) strains-SCCmec IV multiplex PCR.
  33. ncbi Evolution of methicillin-resistant Staphylococcus aureus clones in Latin America
    Eduardo Rodríguez-Noriega
    Hospital Civil de Guadalajara, Fray Antonio Alcalde, Instituto de Patología Infecciosa y Experimental, Centro Universitario Ciencias de la Salud, Universidad de Guadalajara, Jalisco, Mexico
    Int J Infect Dis 14:e560-6. 2010
    b>Methicillin-resistant Staphylococcus aureus (MRSA) is a prominent nosocomial bacterial pathogen, associated with significant morbidity and mortality. The global incidence is increasing, and Latin America is no exception...
  34. pmc Secreted virulence factor comparison between methicillin-resistant and methicillin-sensitive Staphylococcus aureus, and its relevance to atopic dermatitis
    Patrick M Schlievert
    Department of Microbiology, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    J Allergy Clin Immunol 125:39-49. 2010
    Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains have emerged as serious health threats in the last 15 years...
  35. pmc Fitness cost of staphylococcal cassette chromosome mec in methicillin-resistant Staphylococcus aureus by way of continuous culture
    Sui Mae Lee
    Department of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, P O Box 56, Dunedin, New Zealand
    Antimicrob Agents Chemother 51:1497-9. 2007
    ..Type I showed increased glucose consumption and ATP demand per gram of cells synthesized and decreased cell yield compared to those of the parent strain. In contrast, type IV SCCmec elements had no adverse energetic effect...
  36. ncbi Increasing prevalence of methicillin-resistant Staphylococcus aureus infection in California jails
    Erica S Pan
    Department of Pediatrics, San Francisco General Hospital, San Francisco, California 94110, USA
    Clin Infect Dis 37:1384-8. 2003
    ..from patients who were inmates of the San Francisco County jail system showed an increase in the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) from 29%, in 1997, to 74%, in 2002; 91% of the MRSA isolates carried ..
  37. ncbi Meticillin-resistant Staphylococcus aureus
    John M Boyce
    Infectious Diseases Section, Hospital of Saint Raphael, New Haven, CT, USA
    Lancet Infect Dis 5:653-63. 2005
  38. pmc Functional characterization of the sigmaB-dependent yabJ-spoVG operon in Staphylococcus aureus: role in methicillin and glycopeptide resistance
    Bettina Schulthess
    Institute of Medical Microbiology, University of Zurich, Gloriastr 32, 8006 Zurich, Switzerland
    Antimicrob Agents Chemother 53:1832-9. 2009
    ..determinants and global regulators; promotes capsule production; and increases the resistance levels of methicillin-resistant S. aureus (MRSA) and glycopeptide-intermediate-resistant S. aureus (GISA) strains...
  39. ncbi Molecular epidemiology of invasive methicillin-susceptible Staphylococcus aureus strains circulating at a Swiss University Hospital
    L Fenner
    Microbiology Laboratory, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
    Eur J Clin Microbiol Infect Dis 27:623-6. 2008
    In contrast to methicillin-resistant Staphylococcus aureus, little is known of the distribution of spa types among methicillin-susceptible S. aureus (MSSA)...
  40. ncbi Susceptibility of methicillin-resistant staphylococci to oregano essential oil, carvacrol and thymol
    Antonia Nostro
    Dipartimento Farmaco Biologico, Sezione Microbiologia, Facolta di Farmacia, Universita di Messina, Villaggio Annunziata, 98168 Messina, Italy
    FEMS Microbiol Lett 230:191-5. 2004
    The aim of this study was to evaluate the susceptibility of methicillin-susceptible and methicillin-resistant staphylococci (MSS, MRS) to oregano essential oil, carvacrol and thymol. The commercial aerial parts of Origanum vulgare L...
  41. ncbi Comparative analysis of antibiotic and antimicrobial biocide susceptibility data in clinical isolates of methicillin-sensitive Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa between 1989 and 2000
    R J W Lambert
    R2 Scientific, Sharnbrook, Bedfordshire, UK
    J Appl Microbiol 97:699-711. 2004
    ..To analyse population minimum inhibitory concentrations (MICs) data from clinical strains of Staphylococcus aureus and Pseudomonas aeruginosa for changes over a 10-year period and to look for correlations between the antimicrobials tested...
  42. pmc VraT/YvqF is required for methicillin resistance and activation of the VraSR regulon in Staphylococcus aureus
    Susan Boyle-Vavra
    Department of Pediatrics, University of Chicago, Chicago, Illinois, USA
    Antimicrob Agents Chemother 57:83-95. 2013
    Staphylococcus aureus infections caused by strains that are resistant to all forms of penicillin, so-called methicillin-resistant S. aureus (MRSA) strains, have become common...
  43. pmc Identification of the novel dfrK-carrying transposon Tn559 in a porcine methicillin-susceptible Staphylococcus aureus ST398 strain
    Kristina Kadlec
    Institute of Farm Animal Genetics, Friedrich Loeffler Institut FLI, Höltystr 10, 31535 Neustadt Mariensee, Germany
    Antimicrob Agents Chemother 54:3475-7. 2010
    ..to be part of the novel Tn554-related transposon Tn559 integrated in the chromosomal radC gene of a porcine methicillin-susceptible Staphylococcus aureus ST398 strain...
  44. ncbi Factors associated with methicillin-resistant versus methicillin-susceptible Staphylococcus pseudintermedius infection in dogs
    J Scott Weese
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    J Am Vet Med Assoc 240:1450-5. 2012
    To compare methicillin-resistant Staphylococcus pseudintermedius (MRSP) and methicillin-susceptible S pseudintermedius (MSSP) infections in dogs.
  45. ncbi Methicillin-resistant Staphylococcus aureus (MRSA) ST398 in pig farms and multispecies farms
    M Verhegghe
    Food Safety Research Group, Technology and Food Science Unit, Institute for Agricultural and Fisheries Research ILVO, Melle, Belgium
    Zoonoses Public Health 60:366-74. 2013
    During the last few years, methicillin-resistant Staphylococcus aureus (MRSA) ST398 has been isolated frequently from livestock, especially from pigs and to a lesser extent from cattle and poultry...
  46. pmc Rapid screening and identification of methicillin-resistant Staphylococcus aureus from clinical samples by selective-broth and real-time PCR assay
    Hong Fang
    Department of Clinical Bacteriology, Huddinge University Hospital, SE 141 86 Stockholm, Sweden
    J Clin Microbiol 41:2894-9. 2003
    A screening method for methicillin-resistant Staphylococcus aureus (MRSA) by using selective broth and real-time PCR (broth-PCR) was developed and evaluated...
  47. ncbi Selective lethal photosensitization of methicillin-resistant Staphylococcus aureus using an IgG-tin (IV) chlorin e6 conjugate
    Michelle L Embleton
    Department of Microbiology and Cellular Microbiology Research Group, Eastman Dental Institute for Oral Health Care Sciences, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    J Antimicrob Chemother 50:857-64. 2002
    The growing resistance of methicillin-resistant Staphylococcus aureus (MRSA) to conventional antimicrobial agents necessitates the development of alternative approaches to preventing and treating infections...
  48. ncbi Phenotypic and genotypic characteristics of methicillin/oxacillin-resistant Staphylococcus intermedius isolated from clinical specimens during routine veterinary microbiological examinations
    I E M El Zubeir
    Department of Dairy Production, Faculty of Animal Production, University of Khartoum, Khartoum North 13314, Sudan
    Vet Microbiol 121:170-6. 2007
    b>Methicillin/oxacillin resistance of 10 S. intermedius strains was investigated by conventional and molecular methods...
  49. pmc Cell wall monoglycine cross-bridges and methicillin hypersusceptibility in a femAB null mutant of methicillin-resistant Staphylococcus aureus
    A M Stranden
    Institute of Medical Microbiology, University of Zurich, Switzerland
    J Bacteriol 179:9-16. 1997
    ..Allele replacement of the femAB operon with the tetracycline resistance determinant tetK in a methicillin-resistant Staphylococcus aureus strain resulted in impaired growth, methicillin hypersusceptibility, and ..
  50. ncbi Methicillin-resistant Staphylococcus aureus strains in Buenos Aires teaching hospitals: replacement of the multidrug resistant South American clone by another susceptible to rifampin, minocycline and trimethoprim-sulfamethoxazole
    N Gardella
    Catedra de Microbiologia, Facultad de Farmacia y Bioquimica, UBA, Junin 956 1113 Ciudad Autónoma de Buenos Aires, Argentina
    Rev Argent Microbiol 37:156-60. 2005
    The aim of this study was to characterize methicillin-resistant Staphylococcus aureus (MRSA) isolates recovered from different infectious sites of hospitalized patients at two university hospitals...
  51. ncbi Comparison of mecA polymerase chain reaction with phenotypic methods for the detection of methicillin-resistant Staphylococcus aureus
    M M Baddour
    Microbiology and Immunology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt
    Curr Microbiol 55:473-9. 2007
    In the present study, several conventional methods to detect methicillin-resistant Staphylococcus aureus (MRSA) were compared with polymerase chain reaction (PCR) detection of mecA gene-positive isolates...
  52. pmc In vivo pharmacodynamics of torezolid phosphate (TR-701), a new oxazolidinone antibiotic, against methicillin-susceptible and methicillin-resistant Staphylococcus aureus strains in a mouse thigh infection model
    Arnold Louie
    Emerging Infections and Pharmacodynamics Laboratory, Ordway Research Institute, Albany, New York 12208, USA
    Antimicrob Agents Chemother 55:3453-60. 2011
    ..the oxazolidinone TR-700 which demonstrates potent in vitro activity against Gram-positive bacteria, including methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA)...
  53. ncbi Enterocolitis caused by methicillin-resistant Staphylococcus aureus: molecular characterization of respiratory and digestive tract isolates
    H Watanabe
    Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    Microbiol Immunol 45:629-34. 2001
    We investigated the mechanism of outbreak of enterocolitis caused by methicillin-resistant Staphylococcus aureus (MRSA)...
  54. ncbi Characteristics of methicillin resistant Staphylococcus aureus isolated from chicken meat and hospitalized dogs in Korea and their epidemiological relatedness
    Nam Hoon Kwon
    Department of Microbiology, College of Veterinary Medicine, Seoul National University, Sillim dong, Gwanak Gu, Seoul, Republic of Korea
    Vet Microbiol 117:304-12. 2006
    b>Methicillin resistant Staphylococcus aureus (MRSA) is one of the most important pathogens in human and veterinary hospitals. The isolation of MRSA from animals and foodstuffs has been reported with an increased incidence...
  55. ncbi Predictors and outcomes for pregnant women with vaginal-rectal carriage of community-associated methicillin-resistant Staphylococcus aureus
    Katherine T Chen
    Department of Obstetrics and Gynecology, Columbia University, New York, New York 10032, USA
    Am J Perinatol 24:235-40. 2007
    ..to determine the predictors and outcomes of pregnant women with vaginal-rectal carriage of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA)...
  56. pmc The epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in Germany
    Robin Köck
    Institut fur Hygiene, Universitatsklinikum Munster, Germany
    Dtsch Arztebl Int 108:761-7. 2011
    For decades, methicillin-resistant Staphylococcus aureus (MRSA) has been a major cause of infection in hospitals and nursing homes (health care-associated MRSA, HA-MRSA)...
  57. pmc Emergence of community-associated methicillin-resistant Staphylococcus aureus carriage in children in Cambodia
    Emma K Nickerson
    Mahidol Oxford Tropical Medicine Research Unit, and Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 84:313-7. 2011
    We previously described the first reported isolation of methicillin-resistant Staphylococcus aureus (MRSA) (a case series of pediatric community-associated MRSA infections) in Cambodia...
  58. ncbi Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus
    Thaís Moreira Osório
    Laboratório de Antibióticos, Universidade Federal de Santa Catarina UFSC, Campus Trindade, CEP 88040 900 Florianópolis, SC, Brazil
    Bioorg Med Chem Lett 22:225-30. 2012
    ..dihydrochalcones, hydrazones and oxadiazoles were tested against Staphylococcus aureus ATCC 25923 and methicillin-resistant S...
  59. ncbi Methicillin resistance of staphylococci isolated from the skin of dogs with pyoderma
    Stephen A Kania
    Department of Comparative Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Am J Vet Res 65:1265-8. 2004
    To determine the methicillin-resistant profile of staphylococcal isolates from the skin of dogs with pyoderma.
  60. pmc Molecular analysis of repeated methicillin-resistant Staphylococcus aureus infections in children
    Chih Jung Chen
    Divisions of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital and Chang Gung Memorial Hospital, Taoyuan, Taiwan
    PLoS ONE 5:e14431. 2010
    b>Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen that causes severe morbidity and mortality in hospitalized patients...
  61. pmc Population studies of methicillin-resistant and -sensitive Staphylococcus aureus strains reveal a lack of variability in the agrD gene, encoding a staphylococcal autoinducer peptide
    W Van Leeuwen
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Bacteriol 182:5721-9. 2000
    ..A major proportion of the S. aureus strains belong to agr group 1, whereas only 6% of the methicillin-susceptible S. aureus strains and 5% of the methicillin-resistant S...
  62. pmc Frequency of panton-valentine leukocidin-producing methicillin-sensitive Staphylococcus strains in patients with complicated skin and soft tissue infection in bronx, new york
    Anna Kaltsas
    Albert Einstein College of Medicine, Department of Medicine, Infectious Disease Division, 1300 Morris Park Ave, UL 1223, Bronx, NY 10461, USA
    J Clin Microbiol 49:2992-5. 2011
    lukF-PV was present in 36% of skin and soft tissue infection (SSTI)-derived methicillin-susceptible Staphylococcus aureus (MSSA) strains and comprised six distinct clones, which contained fewer enterotoxin genes than strains without lukF-..
  63. ncbi Comparison of both clinical features and mortality risk associated with bacteremia due to community-acquired methicillin-resistant Staphylococcus aureus and methicillin-susceptible S. aureus
    Jiun Ling Wang
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Clin Infect Dis 46:799-806. 2008
    The majority of research about community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infection has focused on skin and soft-tissue infections...
  64. pmc Epidemic methicillin-susceptible Staphylococcus aureus lineages are the main cause of infections at an Iranian university hospital
    Seyed Asghar Havaei
    Isfahan University of Medical Sciences, Isfahan, Iran
    J Clin Microbiol 49:3990-3. 2011
    The majority of Staphylococcus aureus infections from Isfahan, Iran, were caused by epidemic methicillin-susceptible S. aureus (MSSA) lineages, sequence type 8 (ST8), ST22, ST30, and ST6. The predominant methicillin-resistant S...
  65. ncbi Vancomycin-intermediate Staphylococcus aureus with phenotypic susceptibility to methicillin in a patient with recurrent bacteremia
    Timothy S Naimi
    Acute Disease Epidemiology Section and Division of Public Health Laboratories, Minnesota Department of Health, Minneapolis, MN, USA
    Clin Infect Dis 36:1609-12. 2003
    ..All isolates were mecA positive and were indistinguishable by pulsed-field gel electrophoresis. The evolving susceptibility patterns of this strain highlight the challenges of detecting and treating VISA infections...
  66. ncbi No decrease in clindamycin susceptibility despite increased use of clindamycin for pediatric community-associated methicillin-resistant Staphylococcus aureus skin infections
    Jillian M Szczesiul
    Department of Pharmacy, The Johns Hopkins Hospital, The Johns Hopkins University, Baltimore, MD, USA
    Pediatr Infect Dis J 26:852-4. 2007
    A previous study at our institution revealed 98% of methicillin-resistant Staphylococcus aureus (MRSA) isolates were susceptible to clindamycin; however, beta-lactams were then the predominant empiric treatment...
  67. pmc contribution of genetically restricted, methicillin-susceptible strains to the ongoing epidemic of community-acquired Staphylococcus aureus infections
    Rachel C Orscheln
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Infect Dis 49:536-42. 2009
    ..current worldwide epidemic of community-acquired Staphylococcus aureus infections, attention has focused on the role of methicillin-resistant strains. We characterize methicillin-susceptible strains that also contribute to this epidemic.
  68. pmc Molecular epidemiology of methicillin-resistant and methicillin-susceptible Staphylococcus aureus isolated from the eye
    Christine K Hesje
    Bausch and Lomb, Inc, Rochester, New York, USA
    Curr Eye Res 36:94-102. 2011
    b>Methicillin-resistant Staphylococcus aureus (MRSA) strains are commonly classified as hospital-acquired (HA) or community-acquired (CA)...
  69. ncbi Contamination of room door handles by methicillin-sensitive/methicillin-resistant Staphylococcus aureus
    S Oie
    Department of Pharmacy, Yamaguchi University Hospital, 1 1 1 Minamikogushi, Ube 755 8505, Japan
    J Hosp Infect 51:140-3. 2002
    ..Door handles in 53 (27.0%) of 196 rooms were contaminated by methicillin-sensitive Staphylococcus aureus (MSSA) and/or methicillin-resistant Staphylococcus aureus (MRSA); MSSA was ..
  70. pmc Development and evaluation of a chromogenic agar medium for methicillin-resistant Staphylococcus aureus
    John D Perry
    Department of Microbiology, Freeman Hospital, Newcastle upon Tyne, Tyne and Wear, United Kingdom
    J Clin Microbiol 42:4519-23. 2004
    ..and evaluation of MRSA ID, a new chromogenic agar medium for the specific isolation and identification of methicillin-resistant Staphylococcus aureus (MRSA). We used S...
  71. pmc Changes in the nasal colonization with methicillin-resistant Staphylococcus aureus in children: 2004-2009
    Wen Tsung Lo
    Department of Pediatrics, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    PLoS ONE 5:e15791. 2010
    ..This study compared the annual prevalence and microbiological characteristics of methicillin-resistant S. aureus (MRSA) nasal colonization in Taiwanese children from 2004 through 2009...
  72. ncbi Effect of certain bioactive plant extracts on clinical isolates of beta-lactamase producing methicillin resistant Staphylococcus aureus
    Farrukh Aqil
    Department of Agricultural Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, Aligarh 202002 India
    J Basic Microbiol 45:106-14. 2005
    ..activity, were investigated for their ability to inhibit clinical isolates of beta-lactamase producing methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S. aureus (MSSA)...
  73. ncbi High prevalence of methicillin resistant Staphylococcus aureus in pigs
    A J De Neeling
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Vet Microbiol 122:366-72. 2007
    Recently methicillin resistant Staphylococcus aureus (MRSA) was isolated from pigs and pig farmers in The Netherlands...
  74. pmc Epidemiology and susceptibility of 3,051 Staphylococcus aureus isolates from 25 university hospitals participating in the European SENTRY study
    A C Fluit
    Eijkman Winkler Institute for Microbiology, University Medical Center, Utrecht, The Netherlands
    J Clin Microbiol 39:3727-32. 2001
    A total of 3,051 methicillin-susceptible Staphylococcus aureus (MSSA) isolates and methicillin-resistant S. aureus (MRSA) isolates in Europe were compared...
  75. pmc Multiplex PCR for the detection of genes encoding aminoglycoside modifying enzymes and methicillin resistance among Staphylococcus species
    Su Mi Choi
    Department of Internal Medicine, St Mary s Hospital, College of Medicine, University of Korea, Seoul, Korea
    J Korean Med Sci 18:631-6. 2003
    ..genes encoding the most clinically relevant amino-glycoside modifying enzymes (AME), and simultaneously, the methicillin resistant gene, mecA, in Staphylococcus species. Clinical isolates of 45 S...
  76. pmc Validation of pulsed-field gel electrophoresis and spa typing for long-term, nationwide epidemiological surveillance studies of Staphylococcus aureus infections
    M Hallin
    Department of Microbiology, Hopital Erasme, 1070 Brussels, Belgium
    J Clin Microbiol 45:127-33. 2007
    ..fragments has been used by the Belgian Reference Laboratory for Staphylococci for national hospital surveys of methicillin-resistant Staphylococcus aureus since 1992...
  77. ncbi Prevalence of the genes encoding aminoglycoside-modifying enzymes and methicillin resistance among clinical isolates of Staphylococcus aureus in Tehran, Iran
    Abbas Yadegar
    Department of Bacteriology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
    Microb Drug Resist 15:109-13. 2009
    ..encoding the most clinically prevalent aminoglycoside-modifying enzymes, and simultaneous detection of the methicillin resistance gene, mecA, in Staphylococcus aureus isolates. A total of 100 S...
  78. pmc Epidemiology and outcomes of community-associated methicillin-resistant Staphylococcus aureus infection
    S L Davis
    Henry Ford Hospital, Detroit, MI, USA
    J Clin Microbiol 45:1705-11. 2007
    Over a 2-year period (2003 to 2005) patients with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and community-acquired methicillin-susceptible Staphylococcus aureus (CA-MSSA) infections were prospectively ..
  79. ncbi Costs and outcomes among hemodialysis-dependent patients with methicillin-resistant or methicillin-susceptible Staphylococcus aureus bacteremia
    Shelby D Reed
    Center for Clinical and Genetic Economics, USA
    Infect Control Hosp Epidemiol 26:175-83. 2005
    Comorbid conditions have complicated previous analyses of the consequences of methicillin resistance for costs and outcomes of Staphylococcus aureus bacteremia. We compared costs and outcomes of methicillin resistance in patients with S...
  80. ncbi Molecular characteristics of community-acquired methicillin-resistant Staphylococcus aureus in Hokkaido, northern main island of Japan: identification of sequence types 6 and 59 Panton-Valentine leucocidin-positive community-acquired methicillin-resistant
    Mitsuyo Kawaguchiya
    Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan
    Microb Drug Resist 17:241-50. 2011
    Prevalence and molecular characteristics of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) were studied in Hokkaido, the main northern island of Japan. Among the 1,015 S...
  81. pmc Nasal colonization of and clonal transmission of methicillin-susceptible Staphylococcus aureus among Chinese military volunteers
    Fen Qu
    Clinical Diagnostic Center, 302nd Hospital of the People s Liberation Army, Beijing 100039, China
    J Clin Microbiol 48:64-9. 2010
    ..A total of 209 S. aureus isolates were recovered, of which all were methicillin susceptible. Independent factors associated with methicillin-susceptible S...
  82. pmc Regulation of the expression of cell wall stress stimulon member gene msrA1 in methicillin-susceptible or -resistant Staphylococcus aureus
    Roger Pechous
    Microbiology Group, Department of Biological Sciences, Illinois State University, Normal, Illinois 61790 4120, USA
    Antimicrob Agents Chemother 48:3057-63. 2004
    ..In the present study we show that msrA1 induction by oxacillin is common to all methicillin-susceptible strains studied but did not occur in two homogeneous and two heterogeneous methicillin-resistant ..
  83. ncbi Evolution of an inducible penicillin-target protein in methicillin-resistant Staphylococcus aureus by gene fusion
    M D Song
    FEBS Lett 221:167-71. 1987
    ..low affinity to penicillin and most other beta-lactam antibiotics has been widely found in highly beta-lactam(methicillin)-resistant Staphylococcus aureus (MRSA)...
  84. ncbi On the transcriptional regulation of methicillin resistance: MecI repressor in complex with its operator
    Raquel García-Castellanos
    Institut de Biologia Molecular de Barcelona, CID CSIC C Jordi Girona, 18 26, 08034 Barcelona, Spain
    J Biol Chem 279:17888-96. 2004
    ..Most hospital-onset infections are associated with methicillin-resistant Staphylococcus aureus (MRSA) strains that have acquired multiple drug resistance to beta-lactam ..
  85. pmc Recombination between ccrC genes in a type V (5C2&5) staphylococcal cassette chromosome mec (SCCmec) of Staphylococcus aureus ST398 leads to conversion from methicillin resistance to methicillin susceptibility in vivo
    Monika A Chlebowicz
    Department of Medical Microbiology, University Medical Center Groningen, Hanzeplein 1, P O Box 30001, 9700 RB Groningen, The Netherlands
    Antimicrob Agents Chemother 54:783-91. 2010
    Various types of the staphylococcal cassette chromosome mec (SCCmec) are known to confer methicillin resistance on the human pathogen Staphylococcus aureus. Such cassettes are not always stably maintained...
  86. pmc Combination of multiplex PCRs for staphylococcal cassette chromosome mec type assignment: rapid identification system for mec, ccr, and major differences in junkyard regions
    Yoko Kondo
    Department of Infection Control Science, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Antimicrob Agents Chemother 51:264-74. 2007
    ..in combination with genotyping of the Staphylococcus aureus chromosome, has become essential for defining methicillin-resistant S. aureus (MRSA) clones in epidemiological studies...
  87. ncbi The epidemiology of and risk factors for invasive Staphylococcus aureus infections in western Sweden
    Gunnar Jacobsson
    From the Department of Infectious Diseases, Research and Development Centre, Skaraborg Hospital, Skovde, Sweden
    Scand J Infect Dis 39:6-13. 2007
    ..One- quarter of the patients had no history of fever, and one-third of the bacteraemia patients had normal white blood cell count (<10 x 10(9)/l) at presentation. All cases were of MSSA (methicillin-sensitive Staphylococcus aureus).
  88. ncbi Value of performing active surveillance cultures on intensive care unit discharge for detection of methicillin-resistant Staphylococcus aureus
    Jon P Furuno
    Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Infect Control Hosp Epidemiol 28:666-70. 2007
    To quantify the value of performing active surveillance cultures for detection of methicillin-resistant Staphylococcus aureus (MRSA) on intensive care unit (ICU) discharge.
  89. pmc Prevalence and genetic relatedness of methicillin-susceptible Staphylococcus aureus isolates detected by the Xpert MRSA nasal assay
    Sophie S Arbefeville
    Department of Clinical Pathology, Cleveland Clinic, 9500 Euclid Avenue, L40, Cleveland, OH 44195, USA
    J Clin Microbiol 49:2996-9. 2011
    b>Methicillin-susceptible Staphylococcus aureus (MSSA) isolates lacking mecA yet testing positive on the Xpert MRSA assay were recovered from culture for 7.7% of 248 Xpert-positive nasal samples...
  90. ncbi Periprosthetic joint infection: the economic impact of methicillin-resistant infections
    Javad Parvizi
    Rothman Institute of Orthopedics at Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Arthroplasty 25:103-7. 2010
    ..Significantly higher cost of care for treatment of infections due to methicillin-resistant organisms were seen at a mean of $107,264 per case compared to $68,053 for treating PJI caused by ..
  91. ncbi Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus
    H Muroi
    Department of Environmental Science, Policy and Management, University of California, Berkeley 94720 3112, USA
    J Appl Bacteriol 80:387-94. 1996
    The inhibitory and bactericidal activities of anacardic acid and totarol, alone and in combination with methicillin, were investigated against methicillin-resistant Staphylococcus aureus (MRSA)...
  92. pmc Risk factors for hospital-acquired methicillin-resistant Staphylococcus aureus bacteraemia: a case-control study
    D Carnicer-Pont
    National Public Health Service for Wales, Communicable Disease Surveillance Centre, Abton House, Cardiff, UK
    Epidemiol Infect 134:1167-73. 2006
    ..in an acute district general hospital to identify risk factors for hospital-acquired bacteraemia caused by methicillin-resistant Staphylococcus aureus (MRSA)...
  93. ncbi Replacement of methicillin-resistant Staphylococcus aureus clones in Hungary over time: a 10-year surveillance study
    T Conceição
    Laboratorio de Genetica Molecular, Instituto de Tecnologia Química e Biológica da Universidade Nova de Lisboa, Oeiras, Portugal
    Clin Microbiol Infect 13:971-9. 2007
    The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in Hungary has been increasing and is now close to 20% among invasive isolates of S. aureus...
  94. pmc In vitro activities of LTX-109, a synthetic antimicrobial peptide, against methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, daptomycin-nonsusceptible, and linezolid-nonsusceptible Staphylococcus aureus
    Louis D Saravolatz
    St John Hospital and Medical Center, Detroit, Michigan, USA
    Antimicrob Agents Chemother 56:4478-82. 2012
    LTX-109 and eight other antimicrobial agents were evaluated against 155 methicillin-resistant Staphylococcus aureus (MRSA) isolates, including strains resistant to vancomycin and strains with decreased susceptibility to daptomycin and ..
  95. pmc Efficacy of linezolid in treatment of experimental endocarditis caused by methicillin-resistant Staphylococcus aureus
    C F Dailey
    Pharmacology, Pharmacia, Kalamazoo, Michigan 49001, USA
    Antimicrob Agents Chemother 45:2304-8. 2001
    The efficacies of orally (p.o.) dosed linezolid and intravenously (i.v.) dosed vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) in rabbits with experimental aortic-valve endocarditis were investigated...
  96. pmc Vancomycin resistance among methicillin resistant Staphylococcus aureus isolates from intensive care units of tertiary care hospitals in Hyderabad
    Venubabu Thati
    Department of P G Studies and Research in Microbiology, Gulbarga University, Gulbarga, India
    Indian J Med Res 134:704-8. 2011
    Multidrug resistant methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of nosocomial and community acquired infections and is on the rise...
  97. pmc Involvement of methicillin-susceptible Staphylococcus aureus related to sequence type 25 and harboring pvl genes in a case of carotid cavernous fistula after community-associated sepsis
    Paulo V Damasco
    Hospital Pedro Ernesto, State University of Rio de Janeiro, a and Instituto de Microbiologia Paulo de Góes, Federal University of Rio de Janeiro, b Rio de Janeiro, Brazil
    J Clin Microbiol 50:196-8. 2012
    ..We describe a case of carotid cavernous fistula after bacteremia in a 12-year-old male, caused by a methicillin-susceptible S. aureus isolate carrying the pvl, fnbA, and ebpS genes and related to sequence type 25 (ST25)...
  98. ncbi Mechanistic basis for the action of new cephalosporin antibiotics effective against methicillin- and vancomycin-resistant Staphylococcus aureus
    Cosimo Fuda
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    J Biol Chem 281:10035-41. 2006
    Emergence of methicillin-resistant Staphylococcus aureus (MRSA) has created challenges in treatment of nosocomial infections...
  99. ncbi Validation of multiplex PCR strategy for simultaneous detection and identification of methicillin resistant Staphylococcus aureus
    S Rallapalli
    Department of Biotechnology, Indian Institute of Technology Madras, Chennai, India
    Indian J Med Microbiol 26:361-4. 2008
    Multiplex polymerase chain reaction (PCR) strategy is described for rapid identification of clinically relevant methicillin resistant Staphylococcus aureus (MRSA) that targets mecA and coagulase genes...
  100. ncbi Lysostaphin is effective in treating methicillin-resistant Staphylococcus aureus endophthalmitis in the rabbit
    J J Dajcs
    Department of Microbiology, Immunology, and Parasitology, Ehime University School of Medicine, Japan
    Curr Eye Res 22:451-7. 2001
    PURPOSE: To determine the effectiveness of lysostaphin treatment of experimental endophthalmitis caused by methicillin-resistant Staphylococcus aureus (MRSA)...
  101. pmc Continuous versus intermittent infusion of oxacillin for treatment of infective endocarditis caused by methicillin-susceptible Staphylococcus aureus
    Darrel W Hughes
    Department of Pharmacy Services, University Health System, San Antonio, TX 78229, USA
    Antimicrob Agents Chemother 53:2014-9. 2009
    ..outcomes between CI oxacillin and intermittent-infusion (II) oxacillin in the treatment of IE caused by methicillin-susceptible Staphylococcus aureus (MSSA)...

Research Grants75

  1. Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: Preclinic
    Yasmin Wadia; Fiscal Year: 2013
    ..Can be used in a contaminated environment : Sterilizes contaminated wounds of drug- resistant super bugs like Methicillin-Resistant Staphylococcus aureus (MRSA), Streptococcus pyogenes and Pseudomonas aeruginosa...
  2. Novel Bioconjugate Vaccines to Prevent Staphylococcus aureus Infection
    JEAN CLAIRE LEE; Fiscal Year: 2013
    ..Because S. aureus cannot always be controlled by antibiotics and methicillin-resistant isolates are becoming increasingly prevalent in the community, a S. aureus vaccine is sorely needed...
  3. Investigation of Occupational Exposure to and Infection by MRSA in Rural Iowa
    Tara Smith; Fiscal Year: 2012
    ..Research Plan A recent report has documented the clinical impact of methicillin-resistant Staphylococcus aureus (MRSA), suggesting that MRSA caused over 94,000 invasive infections and more ..
  4. Optimization of Neoglycoside Antibiotics for Nosocomial Pathogens and Select Agen
    Arnold Louie; Fiscal Year: 2013
    ..markedly improved activity against a wide variety of multi-resistant Gram-negative bacilli and also against Methicillin-Resistant Staphylococcus aureus (MRSA)...
  5. Vaccine Assembly from Surface Proteins of Staphylococcus Aureus
    Olaf Schneewind; Fiscal Year: 2013
    ..S. aureus strains exhibiting multiple antibiotic resistances, methicillin-resistant S. aureus (MRSA), are isolated in up to 60% of community and 80% of hospital infections. 4...
  6. Carbohydrate-based Antiinfective Agents
    Chi Huey Wong; Fiscal Year: 2013
    ..efforts have primed TGase for long-awaited antibiotic development against dangerous gram-positive strains of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE)...
  7. Development of a Novel PolC Inhibitor as a Gram-Positive Antibiotic
    THALE CROSS JARVIS; Fiscal Year: 2013
    ..These agents exhibit broad-spectrum activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP), Streptococcus ..
  8. Lactoferrin for Immunomodulation of Systemic Inflammatory Response Syndrome
    Marian L Kruzel; Fiscal Year: 2011
    ..The systemic events associated with lactoferrin mediation will also be investigated using methicillin-resistant Staphylococcus aureus bacteria (MRSA) infection, which is troublesome in hospital-associated (..
  9. Defining evolutionary trajectories: Molecular adaptation to antibiotic resistance
    ADIL YOUSIF SHAMOO; Fiscal Year: 2012
    ..Data from 2004 show that despite the best efforts of the medical community, methicillin resisistant Staphylococcus aureus (MRSA) were found in over 60% and vancomycin resistant Enterococci (VRE) in ..
  10. Rapid, Highly Multiplexed and Sensitive Blood Test for Drug-resistant Bacteria
    ARMIN H REITMAIR; Fiscal Year: 2010
    ..faecium, and Shewanella oneidensis as positive control;resistance-specific for methicillin, vancomycin A, and vancomycin B) in purified DNA derived from MSSA, MRSA, VRSA, MSSE, MRSE, VSEfaecalis, vanA ..
  11. National surveillance of emerging MDR in pediatric Enterobacteriaceae infections
    Danielle M Zerr; Fiscal Year: 2013
    ..has been directed at understanding the epidemiology of resistance in Gram-positive organisms, especially methicillin-resistant Staphylococcus aureus, much less is known about the epidemiology of multi-drug resistance in Gram-..
  12. Chicago Community-Acquired Pneumonia Consortium
    Richard G Wunderink; Fiscal Year: 2010
    ..Concern regarding the increase in frequency of community-acquired methicillin- resistant S...
  13. Using PET isotopes to identify drug targets and to diagnose infectious diseases
    Peter J Tonge; Fiscal Year: 2010
    ..The initial focus will be on pathogens such as Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus, however the approach has general applicability...
  14. Host defense against Staphylococcus aureus skin infections
    Lloyd S Miller; Fiscal Year: 2010
    ..These strains include methicillin-resistant S...
  15. Role of Staphylococcus aureus alpha-hemolysin in disease
    Juliane Bubeck Wardenburg; Fiscal Year: 2013
    ..Current epidemic strains harbor genes encoding for resistance to methicillin (MRSA), rendering the once highly potent class of 2-lactam antimicrobials obsolete as therapeutic agents...
  16. Development of Inhaled Vancomycin for Treatment of MRSA Infections in CF
    Taneli Jouhikainen; Fiscal Year: 2012
    ..is developing a novel inhaled dry-powder form of vancomycin (AEROVANC) for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infection, initially in cystic fibrosis (CF) patients and subsequently ..
  17. Boosting Innate Immunity Through HIF to Treat Antibiotic-Resistant Infections
    ROBERT ALAN SHALWITZ; Fiscal Year: 2013
    ..boost HIF-1 in human phagocytes and cause them to kill pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) with efficiency comparable to classical antibiotic therapy...
  18. Oxidative Burst in Influenza and MRSA Co-infection
    Keer Sun; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Influenza-complicated methicillin-resistant S. aureus (MRSA) infection has emerged as a leading cause of death during recent influenza pandemics and epidemics...
  19. Biomarker Screening of Essential Putative Glycoprotease Inhibitor
    Yinduo Ji; Fiscal Year: 2012
    ..provided by applicant): Given the well-known pathogenicity of Staphylococcus aureus, the emergence of methicillin-resistant S. aureus (MRSA) and vancomycin-resistant S...
  20. Pathogensis of Bacterial corneal infection
    Gerald B Pier; Fiscal Year: 2013
    ..For S. aureus, the recent dramatic increase in methicillin-resistant S...
  21. Innovative technologies to effectively treat Multi-drug resistant and/or biofilm-
    Jie Wen; Fiscal Year: 2010
    ..the emergence of multi-drug resistant bacteria (MDR) such as Acinetobacter baumannii, Klebsiella pneumoniae, methicillin-resistant Staphylococcus aureus, and multi-drug resistant Pseudomonas aeruginosa...
  22. Superantigen-Induced Vascular Injury and DIC
    JACK J HAWIGER; Fiscal Year: 2011
    ..Community- acquired Methicillin-Resistant Staphylococcus aureus (CA-MRSA) is responsible for Acute Lung Injury (ALI) associated with ..
  23. Synergy between TLR2 and IL-22R in airway epithelial cells during MRSA challenge
    Jeremy P McAleer; Fiscal Year: 2013
    ..aureus colonizes the nasal passages in 20-50 percent of people, and community-acquired pneumonia caused by methicillin-resistant S. aureus (MRSA) is increasing...
  24. Anti-Autolysin Passive Immunity for MRSA Osteomyelitis
    JOHN LINFORTH DAISS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Recently methicillin resistant Staphylococcus aureus (MRSA) has surpased HIV as the most deadly pathogen in the United States, accounting for over 100,000 deaths per year...
  25. Barcoded Magnetic Beads for Rapid Tests of MRSA and Respiratory Viral Panels
    WINSTON Z HO; Fiscal Year: 2010
    ..The human and financial impact of Methicillin-resistant Staphylococcus aureus (MRSA) is high. MRSA now accounts for greater than 60% of hospital-acquired S...
  26. Impact of the Nasal Microbiome on S. aureus Colonization and Infection
    Mary Bessesen; Fiscal Year: 2013
    ..The attributable mortality associated with methicillin sensitive S. aureus bloodstream infection is 19% and this rises to 33% if S...
  27. Prevalance of Community-Acquired MRSA in Live Pigs and thier Human Handlers
    LYNDA UJU ODOFIN; Fiscal Year: 2010
    ..by applicant): There is now growing evidence that livestock may be involved in spread of community-associated Methicillin Resistant Staphylococcus aureus (CA-MRSA);recent studies from Europe and Canada report a new strain (ST 398) ..
  28. Chicago Prevention and Intervention Epicenter (Chicago PIE)
    ROBERT ALAN WEINSTEIN; Fiscal Year: 2013
    ..First, multi-drug resistant organisms (MDROs) - methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant gram-negative bacilli - and Clostridium ..
  29. Identification of genes essential for survival of hypervirulent Kleb. pneumoniae
    Thomas A Russo; Fiscal Year: 2012
    ..and MDR in hvKP has the potential to create a "post-antibiotic" scenario;similar to what was feared with methicillin resistant Staphylococcus aureus (MRSA) but was never realized...
  30. Broad-Spectrum Antimicrobials Targeting the D-Alanine Pathway
    KAREN G ANTHONY; Fiscal Year: 2013
    ..the spectrum of activity of these agents against Bacillus anthracis, the causative agent of anthrax, and methicillin-resistant Staphylococcus aureus (MRSA), the causative agent of life threatening bacteremia...
  31. Synethic protein and peptide assemblies as novel adjuvants and vaccines
    Joel H Collier; Fiscal Year: 2012
    ..full-length proteins, and to test them as a protective modality for clinically important community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). Antibodies (Abs) against the S...
  32. Epitope-specific vaccines targeting the alpha toxin of Staphylococcus aureus
    KEMP BAILEY CEASE; Fiscal Year: 2013
    ..In particular, methicillin-resistant S...
  33. Quorum sensing-dependent interactions with biofilms and innate immunity defenses
    Alexander R Horswill; Fiscal Year: 2012
    ..aim, we will also compare the transition mechanisms of laboratory strains with the community-associated methicillin resistant strains (CA-MRSA), in order to gain insight into the contribution of quorum-sensing to the ..
  34. The Role of SaeR/S During Staphylococcus aureus Skin Infections
    Jovanka M Voyich; Fiscal Year: 2012
    ..A recent report identified methicillin-resistant S...
  35. Chicago Community-Acquired Pneumonia Consortium II
    Richard G Wunderink; Fiscal Year: 2013
    ..We will also address concern regarding an increased incidence of community-acquired methicillin-resistant S. aureus (CA-MRSA) pneumonia...
  36. Antimicrobial Lipids within the Oral Cavity
    PHILIP WESLEY WERTZ; Fiscal Year: 2010
    ..of ethanol and is capable of killing an isolate of Staphylococcus aureus that is resistant to both methicillin and mupirocin...
  37. A Modulator of Innate Immunity for Preventing Hospital-Acquired Infections
    James D Thacker; Fiscal Year: 2010
    ..in large part to the alarming rate at which pathogens are acquiring resistance to antibiotics, such as methicillin-resistant Staphylococcus aureus (MRSA)...
  38. Bacterial fermentation in skin microbiome as probiotics (Bfismp) against S. aureu
    Chun Ming Huang; Fiscal Year: 2013
    ..In this proposal, we will use the bacterial fermentation in skin microbiome as probiotics (Bfismp) against methicillin-resistant Staphylococcus aureus (MRSA)...
  39. Engineering Soluble T Cell Receptors to Treat Exotoxin Induced Pulmonary Disease
    DAIVA MARIA MATTIS; Fiscal Year: 2013
    ..have shown that these exotoxins contribute directly to severe lung infection caused by Community- Associated Methicillin-Resistant S. Aureus (CA-MRSA)...
  40. Hemostatic-antibiotic Combination for Prevention of MRSA Surgical Site Infections
    Timothy C Fisher; Fiscal Year: 2010
    ..period to reduce the probability of against infection of the wound or the bone (osteomyelitis) by methicillin- resistant Staphylococci (e.g., MRSA or MRSE), as an adjunct to systemic antibiotic prophylaxis...
  41. Nitric Oxide-Releasing Wound Dressing for Preventing Chronic Wound Infections
    NATHAN ALLAN STASKO; Fiscal Year: 2012
    ..of diabetic foot ulcers is further complicated by the presence of multidrug resistant pathogens like MRSA methicillin resistant Staphylococcus aureus) and Pseudomonas aeruginosa...
  42. Rapid Novel Molecular Detection of Methicillin-Resistant Staphylococcus aureus
    ELENA ANATOLIEVNA USACHEVA; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Methicillin-resistant Staphylococcus aureus (MRSA) is the causative agent of a wide diversity of diseases ranging from benign skin infection to life-threatening diseases such as endocarditis, ..
  43. Molecular Engineering of Humanized Anti-Staphlococcal Lytic Enzymes
    Karl E Griswold; Fiscal Year: 2012
    ..aureus infections and ~50% of those acquired in the community are now methicillin-resistant (MRSA). The increasing incidence of multidrug-resistance in S...
  44. Novel Mechanisms of Beta-lactam Resistance in Staph Aureus
    Henry F Chambers; Fiscal Year: 2013
    ..This new type of resistance was identified during experiments in which methicillin- susceptible S...
  45. B-lactam mediated SOS response and expression of resistance in clinical MRSA
    Adriana E Rosato; Fiscal Year: 2013
    ..have shown that the morbidity and mortality in infections due to MRSA are considerably higher than in MSSA (methicillin susceptible Staphylococcus aureus) infections, mainly because of an inadequate initial antimicrobial therapy...
  46. Role of the Staphylococcus aureus SaeR/S Regulatory System in Neutrophil Evasion
    Jovanka M Voyich; Fiscal Year: 2013
    ..Recently, there has been an increase in the incidence of community-associated methicillin-resistant S...
  47. Discovering New Anti-Infective Agents from Lysobacter
    Liangcheng Du; Fiscal Year: 2013
    ..WAP-8294A are a complex of at least 20 cyclic lipodepsipeptides with a potent activity against Methicillin-Resistant Staphylococcus aureus (MRSA, ED5014 times more active than vancomycin, a "last resort" antibiotic)...
  48. Contact Network Epidemiology of Influenza and Other Nosocomial Infections
    ALBERTO MARIA contact SEGRE; Fiscal Year: 2010
    ..to simulate diffusion of commonly-occurring hospital-acquired infections, and, more specifically, influenza and methicillin-resistant Staphylococcus aureus (MRSA)...
  49. Targeted Infection Prevention (TIP) Program in Nursing Homes
    Lona Mody; Fiscal Year: 2013
    ..Many of these infections are caused by multiple drug resistant organisms (MDROs) including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and multidrug resistant Gram-..
  50. Catalytic Antibodies To Staphylococcus Aureus: Identification and Characterizatio
    Eric L Brown; Fiscal Year: 2010
    ..Of growing concern are the steadily growing numbers of community-acquired methicillin-resistant S. aureus (CA-MRSA) infections in young, otherwise healthy people...
  51. Prevention of Nosocomial Infections and Cost-Effectiveness Refined (P-NICER)
    Patricia W Stone; Fiscal Year: 2012
    ..This work represents a significant contribution to the field. However, with increased HAIs caused by methicillin resistant Staphylococcus aureus (MRSA) and Clostridium difficile (C...
  52. Apolipoprotein B and Control of S. aureus Quorum Sensing
    PAMELA RANEL HALL; Fiscal Year: 2013
    ..Particularly problematic are methicillin resistant S...
  53. Influenza A Inhibits TH17 Host Defense Against Bacterial Pneumonia
    John F Alcorn; Fiscal Year: 2013
    ..Incidence and severity of S. aureus pneumonia is increasing worldwide due to the emergence of methicillin-resistant (MRSA) strains...
  54. Project CLEAR - Changing Lives by Eradicating Antibiotic Resistance
    Susan S Huang; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Methicillin-resistant Staphylococcus aureus (MRSA) are highly antibiotic resistant bacteria that either colonize or infect 1.8 million hospitalized patients in the United States each year...
  55. Connecticut Emerging Infections Program
    MATTHEW LEWIS CARTTER; Fiscal Year: 2011
    ..by Streptococcus pnetononiae, Haemophihts influenzae, Neisseria menhTgitidis, groups A and B streptococci, methicillin-resistant Staphylococcus attreus, and performs prevention and control projects;2) FoodNet: statewide ..
  56. Etiology of microvascular changes in Gram-positive sepsis: mechanisms and therape
    Perenlei Enkhbaatar; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Methicillin-resistant Staphylococcus aureus (MRSA) infection has become a serious health problem both in the community and in hospitals. ~20,000 people die annually in the U.S...
  57. Targeting Staphylococcus aureus Virulence
    Hattie D Gresham; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Methicillin resistant Staphylococcus aureus (MRSA) has emerged as a major public health threat and the expansion worldwide of a single clone (USA300) associated with life threatening infections even ..
  58. Novel Methodology for Rapid Antibiotic Susceptibiility Testing in S. aureus
    Alexis F Sauer Budge; Fiscal Year: 2010
    ..We propose to use the model system of Staphylococcus aureus, both methicillin-susceptible and methicillin- resistant strains...
  59. Conjunctival Goblet Cell NLRP3 Inflammasome in Ocular Surface Bacterial Infection
    Darlene A Dartt; Fiscal Year: 2013
    ..If untreated, corneal infections in particular can be sight threatening In addition, the emergence of methicillin-resistant S. aureus makes development of new approaches to control ocular surface infections an immediate goal...
  60. STAPHYLOCOCCAL METHICILLIN RESISTANCE LOCUS
    Gordon Archer; Fiscal Year: 2009
    Project Summary Methicillin-resistant Staphylococcus aureus (MRSA) are the most common and lethal causes of infections of hospitalized patients and, over the past decade, have appeared in the community as an increasingly common cause of ..
  61. Bacterial Quorum Sensing as Target for Anti-Infective Immunotherapy
    Bin Zhou; Fiscal Year: 2013
    ..With the emergence of more highly antibiotic-resistant bacterial strains ("superbugs"), most notably methicillin-resistant S. aureus (MRSA) and P...
  62. Structure and Cell-Wall Targeting of the Staphylolytic Enzyme Lysostaphin
    KEITH GRISCOM INMAN; Fiscal Year: 2010
    ..The enzyme lysostaphin kills virtually all strains of S. aureus, including methicillin-resistant S. aureus (MRSA)...
  63. HTS assay and configuration for inhibitors of the UDP-Mur formation pathway
    Michael McNeil; Fiscal Year: 2009
    ..In addition, new inhibitors of PG synthesis are needed for eubacteria in general, such a methicillin resistant Staphylococcus aureus and bioterrorist agents including Burkholderia pseudomallei and Yersinia pestis...
  64. Defining the bacterial factors that modulate sensitivity to B-lactam in CA-MRSA
    AMBROSE LIN YAU CHEUNG; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Recent cases of infections caused by community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) strains in healthy individuals have raised concerns worldwide...
  65. METHICILLIN RESISTANCE OF STAPHYLOCOCCUS AUREUS
    Henry Chambers; Fiscal Year: 1993
    The objective of the proposed research is to identify the components and their interrelationships controlling methicillin resistance in Staphylococcus aureus...
  66. Statewide Implementation of Guidelines to Control MRSA
    Loreen Herwaldt; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Methicillin (oxacillin)-resistant Staphylococcus aureus (MRSA) is by far the most common resistant bacterial pathogen...
  67. High-Throughput Identification of RNA polymerase inhibitors in vivo
    Robert Landick; Fiscal Year: 2006
    ..b>Methicillin-resistant Staphylococcus aureus (MRSA) is already spreading rapidly outside hospitals in the US and globally, ..
  68. Genetic Basis of Virulence of Community MRSA Clone USA300
    Henry F Chambers; Fiscal Year: 2010
    ..It can cause rapidly fatal infections. A highly virulent clone of methicillin resistant S. aureus (MRSA), USA300, is epidemic in communities in the United States...
  69. REGULATION OF BETA-LACTAMASE IN STAPHYLOCOCCUS AUREUS
    Corinne Hackbarth; Fiscal Year: 2000
    ..Broader resistance to methicillin and all other beta-lactam antibiotics is mediated by PBP2a and is prevalent in many hospitals...
  70. Detection of Antibiotic Resistance Genes in Bacterial Agents of Hospital-Acquired
    Andrew Levin; Fiscal Year: 2009
    ..resistance, including resistance to [unreadable]-lactams and fluoroquinolones in Gram-negative bacteria, and to methicillin and vancomycin in Gram-positive bacteria...
  71. ORGANIC NANOTUBES DESIGN AND BIOLOGICAL APPLICATIONS
    M Ghadiri; Fiscal Year: 2009
    ..against multidrug-resistant bacterial infections including vancomycin-resistant Enterococcus faecalis (VRE) and methicillin-resistant Staphylococcus aureus (MRSA)...
  72. PENICILLIN INTERACTIVE PROTEINS OF STAPHYLOCOCCUS AUREUS
    Henry Chambers; Fiscal Year: 2003
    b>Methicillin-resistant strains of Staphylococcus aureus are a major clinical problem...
  73. Etiology, Epidemiology, and Clinical Outcomes of Health Care Associated Pneumonia
    Karl Madaras Kelly; Fiscal Year: 2009
    ..therapy such as guideline similar therapy (GTS)];2) identify risk factors for MDR bacteria including Methicillin-Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa, compared to non-MDR bacteria and develop ..
  74. Proline uptake in staphylococcus aureus pathogenesis
    WILLIAM SCHWAN; Fiscal Year: 2002
    ..penicillin and up to fifty percent of all strains isolated from patients in hospitals are resistant to methicillin. Recent outbreaks of community-acquired S...
  75. STAPHYLOCOCCAL VANCOMYCIN AND METHICILLIN RESISTANCE
    BRIAN WILKINSON; Fiscal Year: 2001
    ..Most hospital strains of S. aureus are now methicillin-resistant (MRSA), and such strains are typically resistant to multiple other antibiotics...