penicillins

Summary

Summary: A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)

Top Publications

  1. pmc Two components of a velvet-like complex control hyphal morphogenesis, conidiophore development, and penicillin biosynthesis in Penicillium chrysogenum
    Birgit Hoff
    Christian Doppler Laboratory for Fungal Biotechnology, Lehrstuhl für Allgemeine und Molekulare Botanik, Ruhr Universitat Bochum, Universitatsstrasse 150, 44780 Bochum, Germany
    Eukaryot Cell 9:1236-50. 2010
  2. ncbi The effect of penicillin on Chlamydia trachomatis DNA replication
    Paul R Lambden
    Molecular Microbiology Group, University of Southampton Medical School, MP814, Southampton General Hospital, Hampshire SO16 6YD, UK
    Microbiology 152:2573-8. 2006
  3. pmc The human milk protein-lipid complex HAMLET sensitizes bacterial pathogens to traditional antimicrobial agents
    Laura R Marks
    Department of Microbiology and Immunology, University at Buffalo, State University of New York, Buffalo, New York, United States of America
    PLoS ONE 7:e43514. 2012
  4. ncbi Increased penicillin nonsusceptibility of nonvaccine-serotype invasive pneumococci other than serotypes 19A and 6A in post-7-valent conjugate vaccine era
    Robert E Gertz
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 201:770-5. 2010
  5. ncbi Identification of the novel penicillin biosynthesis gene aatB of Aspergillus nidulans and its putative evolutionary relationship to this fungal secondary metabolism gene cluster
    Petra Spröte
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, 07745 Jena, Germany
    Mol Microbiol 70:445-61. 2008
  6. ncbi Fungal secondary metabolism - from biochemistry to genomics
    Nancy P Keller
    University of Wisconsin Madison, Department of Plant Pathology, 882 Russell Labs, 1630 Linden Drive, Madison, Wisconsin 53706, USA
    Nat Rev Microbiol 3:937-47. 2005
  7. ncbi Rationale for revised penicillin susceptibility breakpoints versus Streptococcus pneumoniae: coping with antimicrobial susceptibility in an era of resistance
    Melvin P Weinstein
    Department of Medicine, University of Medicine and Dentistry, New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08901 1109, USA
    Clin Infect Dis 48:1596-600. 2009
  8. pmc Cell wall monoglycine cross-bridges and methicillin hypersusceptibility in a femAB null mutant of methicillin-resistant Staphylococcus aureus
    A M Stranden
    Institute of Medical Microbiology, University of Zurich, Switzerland
    J Bacteriol 179:9-16. 1997
  9. pmc Penicillin for acute sore throat: randomised double blind trial of seven days versus three days treatment or placebo in adults
    S Zwart
    Julius Center for General Practice and Patient Oriented Research, University Medical Center Utrecht, 3584 CG Utrecht, Netherlands
    BMJ 320:150-4. 2000
  10. ncbi Penicillins for treatment of pneumococcal pneumonia: does in vitro resistance really matter?
    Lance R Peterson
    Evanston Northwestern Healthcare Research Institute, Division of Microbiology, Department of Pathology and Laboratory Medicine, Northwestern University, Evanston, IL, USA
    Clin Infect Dis 42:224-33. 2006

Detail Information

Publications272 found, 100 shown here

  1. pmc Two components of a velvet-like complex control hyphal morphogenesis, conidiophore development, and penicillin biosynthesis in Penicillium chrysogenum
    Birgit Hoff
    Christian Doppler Laboratory for Fungal Biotechnology, Lehrstuhl für Allgemeine und Molekulare Botanik, Ruhr Universitat Bochum, Universitatsstrasse 150, 44780 Bochum, Germany
    Eukaryot Cell 9:1236-50. 2010
    ..chrysogenum, with structurally conserved components that have distinct developmental roles, illustrating the functional plasticity of these regulators in genera other than Aspergillus...
  2. ncbi The effect of penicillin on Chlamydia trachomatis DNA replication
    Paul R Lambden
    Molecular Microbiology Group, University of Southampton Medical School, MP814, Southampton General Hospital, Hampshire SO16 6YD, UK
    Microbiology 152:2573-8. 2006
    ..In these RBs, the DNA continued to replicate well beyond the end of the normal developmental cycle. At 60 h p.i. each aberrant RB contained a minimum of 16 chromosomal copies...
  3. pmc The human milk protein-lipid complex HAMLET sensitizes bacterial pathogens to traditional antimicrobial agents
    Laura R Marks
    Department of Microbiology and Immunology, University at Buffalo, State University of New York, Buffalo, New York, United States of America
    PLoS ONE 7:e43514. 2012
    ..In this study we show that sublethal concentrations of HAMLET potentiate the effect of common antibiotics (penicillins, macrolides, and aminoglycosides) against pneumococci...
  4. ncbi Increased penicillin nonsusceptibility of nonvaccine-serotype invasive pneumococci other than serotypes 19A and 6A in post-7-valent conjugate vaccine era
    Robert E Gertz
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 201:770-5. 2010
    ....
  5. ncbi Identification of the novel penicillin biosynthesis gene aatB of Aspergillus nidulans and its putative evolutionary relationship to this fungal secondary metabolism gene cluster
    Petra Spröte
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, 07745 Jena, Germany
    Mol Microbiol 70:445-61. 2008
    ..Our findings suggest that aatB is a paralogue of aatA. They extend the model of evolution of the penicillin biosynthesis gene cluster by recruitment of a biosynthesis gene and its cis-regulatory sites upon gene duplication...
  6. ncbi Fungal secondary metabolism - from biochemistry to genomics
    Nancy P Keller
    University of Wisconsin Madison, Department of Plant Pathology, 882 Russell Labs, 1630 Linden Drive, Madison, Wisconsin 53706, USA
    Nat Rev Microbiol 3:937-47. 2005
    ....
  7. ncbi Rationale for revised penicillin susceptibility breakpoints versus Streptococcus pneumoniae: coping with antimicrobial susceptibility in an era of resistance
    Melvin P Weinstein
    Department of Medicine, University of Medicine and Dentistry, New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08901 1109, USA
    Clin Infect Dis 48:1596-600. 2009
    ..Clinicians, once again, should feel comfortable prescribing penicillin for pneumococcal pneumonia and other pneumococcal infections outside the central nervous system...
  8. pmc Cell wall monoglycine cross-bridges and methicillin hypersusceptibility in a femAB null mutant of methicillin-resistant Staphylococcus aureus
    A M Stranden
    Institute of Medical Microbiology, University of Zurich, Switzerland
    J Bacteriol 179:9-16. 1997
    ..Moreover, it can be deduced that addition of the first glycine must occur by a femAB-independent mechanism...
  9. pmc Penicillin for acute sore throat: randomised double blind trial of seven days versus three days treatment or placebo in adults
    S Zwart
    Julius Center for General Practice and Patient Oriented Research, University Medical Center Utrecht, 3584 CG Utrecht, Netherlands
    BMJ 320:150-4. 2000
    ..To assess whether treatment with penicillin for three days and the traditional treatment for seven days were equally as effective at accelerating resolution of symptoms in patients with sore throat compared with placebo...
  10. ncbi Penicillins for treatment of pneumococcal pneumonia: does in vitro resistance really matter?
    Lance R Peterson
    Evanston Northwestern Healthcare Research Institute, Division of Microbiology, Department of Pathology and Laboratory Medicine, Northwestern University, Evanston, IL, USA
    Clin Infect Dis 42:224-33. 2006
    ..In particular, resistance of Streptococcus pneumoniae to beta-lactam antibiotic therapy has assumed a prominent role in the evolution of guidelines for the initial treatment of respiratory tract infection...
  11. ncbi The enzymes of β-lactam biosynthesis
    Refaat B Hamed
    University of Oxford, Department of Chemistry, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK
    Nat Prod Rep 30:21-107. 2013
    ..Most, but not all, β-lactams including penicillins, cephalosporins, and clavulanic acid are produced via fermentation or via modification of fermented ..
  12. ncbi The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum
    Katarina Kosalkova
    Instituto de Biotecnologia, Leon, Spain
    Biochimie 91:214-25. 2009
    ..These results evidence that PcLaeA not only controls some secondary metabolism gene clusters, but also asexual differentiation in P. chrysogenum...
  13. ncbi Recent advances in the biosynthesis of penicillins, cephalosporins and clavams and its regulation
    Gulay Ozcengiz
    Middle East Technical University, Dumlupinar Bulv, 06800 Ankara, Turkey
    Biotechnol Adv 31:287-311. 2013
    ..Sales of these remarkable compounds have reached over $20 billion dollars per year. They include penicillins, cephalosporins, cefoxitin, monobactams, clavulanic acid and carbapenems...
  14. ncbi BOLD signal increase preceeds EEG spike activity--a dynamic penicillin induced focal epilepsy in deep anesthesia
    Minna Mäkiranta
    Department of Diagnostic Radiology, University of Oulu, Kajaanintie 50, 90220 Oulu, Finland
    Neuroimage 27:715-24. 2005
    ..This experimental model contains potential for development and testing different localization methods and revealing the characteristic time sequence of epileptic activity with fMRI during deep anesthesia...
  15. ncbi Antibiotics for leptospirosis
    David M Brett-Major
    U S Military Tropical Medicine, Navy Medicine Manpower, Personnel, Training and Education Command NAVMED MPT and E, Bethesda, MD, USA
    Cochrane Database Syst Rev 2:CD008264. 2012
    ..Case attack rates are as high as 1:4 to 2:5 persons in exposed populations. In some settings mortality has exceeded 10% of infected people. The benefit of antibiotic therapy in the disease has been unclear...
  16. pmc Penicillin induced persistence in Chlamydia trachomatis: high quality time lapse video analysis of the developmental cycle
    Rachel J Skilton
    Molecular Microbiology Group, University of Southampton Medical School, Southampton General Hospital, Southampton, UK
    PLoS ONE 4:e7723. 2009
    ..We have applied video microscopy and quantitative DNA assays to the chlamydial developmental cycle to assess the effects of penicillin treatment and establish a framework for investigating penicillin induced chlamydial persistence...
  17. ncbi Evolution of Streptococcus pneumoniae serotypes and penicillin susceptibility in Latin America, Sireva-Vigía Group, 1993 to 1999. PAHO Sireva-Vigía Study Group. Pan American Health Organization
    J L Di Fabio
    Division of Vaccines and Immunization, Pan American Health Organization, Washington, DC, USA
    Pediatr Infect Dis J 20:959-67. 2001
    ....
  18. ncbi Invasive pneumococcal disease in children aged <5 years admitted to 3 urban hospitals in Ibadan, Nigeria
    A G Falade
    Department of Pediatrics, University College Hospital and College of Medicine, University of Ibadan, Ibadan, Nigeria
    Clin Infect Dis 48:S190-6. 2009
    ..pneumoniae...
  19. ncbi Host adaptation of bovine Staphylococcus aureus seems associated with bacteriological cure after lactational antimicrobial treatment
    B H P van den Borne
    Faculty of Veterinary Medicine, Utrecht University, Yalelaan 7, 3584 CL Utrecht, The Netherlands
    J Dairy Sci 93:2550-8. 2010
    ..For diagnostic purposes, a simple and fast alternative to multilocus sequence typing of Staph. aureus to determine host adaptation may be valuable...
  20. pmc Autophagy deficiency promotes beta-lactam production in Penicillium chrysogenum
    Magdalena Bartoszewska
    Molecular Cell Biology, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Appl Environ Microbiol 77:1413-22. 2011
    ..This phenomenon is associated with an increase in the enzyme levels of the PEN biosynthetic pathway and enhanced production levels of this antibacterial compound...
  21. pmc Molecular and structural analysis of mosaic variants of penicillin-binding protein 2 conferring decreased susceptibility to expanded-spectrum cephalosporins in Neisseria gonorrhoeae: role of epistatic mutations
    Joshua Tomberg
    Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599 7365, USA
    Biochemistry 49:8062-70. 2010
    ..4 μg/mL) and cefixime (1.2 μg/mL) to levels above their respective break points. The proposed structural mechanisms of these mutations are discussed in light of the recently published structure of PBP 2...
  22. pmc Complementation of the essential peptidoglycan transpeptidase function of penicillin-binding protein 2 (PBP2) by the drug resistance protein PBP2A in Staphylococcus aureus
    M G Pinho
    Laboratory of Microbiology, The Rockefeller University, New York, New York 10021, USA
    J Bacteriol 183:6525-31. 2001
    ..Several lines of evidence indicate that the essential function of PBP2 that can be compensated for by PBP2A is the transpeptidase activity. This provides direct genetic evidence that PBP2A has transpeptidase activity...
  23. pmc BOCILLIN FL, a sensitive and commercially available reagent for detection of penicillin-binding proteins
    G Zhao
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285 0438, USA
    Antimicrob Agents Chemother 43:1124-8. 1999
    ..Finally, this method also allowed us to compare relative affinities of a PBP2x protein for different beta-lactam antibiotics with the aid of fluorescence polarization technology and to monitor a PBP2x protein during purification...
  24. pmc Contribution of peroxisomes to penicillin biosynthesis in Aspergillus nidulans
    Petra Spröte
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, Jena, Germany
    Eukaryot Cell 8:421-3. 2009
    ..This is in contrast to the effects of IAT mislocalization in Penicillium chrysogenum...
  25. pmc Synergy of daptomycin with oxacillin and other beta-lactams against methicillin-resistant Staphylococcus aureus
    Kenneth H Rand
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida 32610, USA
    Antimicrob Agents Chemother 48:2871-5. 2004
    ..The combination of daptomycin and beta-lactams may be useful for the treatment of MRSA infection, but further studies are needed to elucidate the mechanisms and to determine the in vivo efficacy of the combination...
  26. ncbi Mechanisms of action of corilagin and tellimagrandin I that remarkably potentiate the activity of beta-lactams against methicillin-resistant Staphylococcus aureus
    Sumiko Shiota
    Department of Pathogenic Microbiology, School of Pharmacy, Shujitsu University, Okayama, Japan
    Microbiol Immunol 48:67-73. 2004
    ..Corilagin or tellimagrandin I suppressed the activity of beta-lactamase to some extent...
  27. pmc Serotype distribution and penicillin resistance of Streptococcus pneumoniae isolates from middle ear fluids of pediatric patients with acute otitis media in Japan
    Muneki Hotomi
    Department of Otolaryngology, Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama Shi, Wakayama 640 8501, Japan
    J Clin Microbiol 46:3808-10. 2008
    ..Serotypes 19F and 23F occurred most frequently among PRSP strains. The 7-valent pneumococcal conjugate vaccine (PCV) showed better coverage of PRSP strains (87.0%). The 7-valent PCV may reduce the prevalence of PRSP in Japan...
  28. ncbi Effectiveness of clinical guidelines for the presumptive treatment of streptococcal pharyngitis in Egyptian children
    M C Steinhoff
    Department of International Health, School of Hygiene and Public Health, Baltimore MD, USA
    Lancet 350:918-21. 1997
    ..We evaluated the WHO Acute Respiratory Infection guideline in a large urban paediatric clinic in Egypt...
  29. pmc Crystal structures of penicillin-binding protein 2 from penicillin-susceptible and -resistant strains of Neisseria gonorrhoeae reveal an unexpectedly subtle mechanism for antibiotic resistance
    Ailsa J Powell
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 284:1202-12. 2009
    ....
  30. ncbi The 2.4-A crystal structure of the penicillin-resistant penicillin-binding protein PBP5fm from Enterococcus faecium in complex with benzylpenicillin
    E Sauvage
    Centre d Ingénierie des Protéines, Universite de Liege, Institut de Physique, Belgium
    Cell Mol Life Sci 59:1223-32. 2002
    ..Moreover, the insertion of a serine after residue 466 in the most resistant strains underlines even more the determining role of this loop in the recognition of the substrates...
  31. ncbi Different growth rates of Chlamydia trachomatis biovars reflect pathotype
    Isao Miyairi
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Infect Dis 194:350-7. 2006
    ..Despite small genomic differences, Chlamydia trachomatis biovars exhibit diverse disease manifestations and different growth rates in vivo and in cell culture models...
  32. pmc Evolution of clonal and susceptibility profiles of serotype 19A Streptococcus pneumoniae among invasive isolates from children in Spain, 1990 to 2008
    David Tarrago
    National Center of Microbiology, Servicio de Microbiología Diagnóstica, Instituto de Salud Carlos III, Majadahonda Pozuelo Km 2, 28220 Majadahonda, Madrid, Spain
    Antimicrob Agents Chemother 55:2297-302. 2011
    ..The rapid expansion of serotype 19A and STs related to antibiotic resistance indicates that vaccines covering serotype 19A present advantages in countering invasive disease...
  33. ncbi Penicillium chrysogenum Pex14/17p--a novel component of the peroxisomal membrane that is important for penicillin production
    Lukasz Opaliński
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands
    FEBS J 277:3203-18. 2010
    ..Possibly, this compensates for the fact that P. chrysogenum lacks an authenthic Pex17p. We also show that, in P. chrysogenum, Pex14/17p plays a role in making the penicillin biosynthesis process more efficient...
  34. ncbi Intracellular metabolite determination in the presence of extracellular abundance: Application to the penicillin biosynthesis pathway in Penicillium chrysogenum
    Rutger D Douma
    Department of Biotechnology, Delft University of Technology, Kluyver Centre for Genomics of Industrial Fermentation, BC Delft, The Netherlands
    Biotechnol Bioeng 107:105-15. 2010
    ....
  35. pmc Population snapshot of Streptococcus pneumoniae serotype 19A isolates before and after introduction of seven-valent pneumococcal Vaccination for French children
    Farah Mahjoub-Messai
    Service de Microbiologie, Hôpital Robert Debré APHP, 75019 Paris, France
    J Clin Microbiol 47:837-40. 2009
    ..By applying multilocus sequence typing to 144 serotype 19A isolates collected before and after beginning PCV7 vaccination, we detected clonal expansion of the preexisting penicillin-intermediate sequence type 276...
  36. pmc New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria
    Samo Turk
    Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
    PLoS ONE 6:e19418. 2011
    ..To address this problem we focused our attention to discovery of novel noncovalent inhibitors of PBPs...
  37. ncbi Development of the semi-synthetic penicillins and cephalosporins
    J M T Hamilton-Miller
    Department of Medical Microbiology, Royal Free and University College Medical School, London, UK
    Int J Antimicrob Agents 31:189-92. 2008
    Semi-synthetic penicillins and cephalosporins both derive from their respective chemical nuclei, 6-aminopenicillanic acid (6-APA) and 7-aminocephalosporanic acid (7-ACA)...
  38. pmc A peptidoglycan fragment triggers β-lactam resistance in Bacillus licheniformis
    Ana Amoroso
    Centre d Ingénierie des Protéines, Institut de Chimie B6a, Sart Tilman, Belgium
    PLoS Pathog 8:e1002571. 2012
    ..The new model proposed confirms and emphasizes the role of peptidoglycan degradation fragments in bacterial cell regulation...
  39. pmc In vitro activity of ceftaroline against clinical isolates of Streptococcus pneumoniae recovered in 43 U.S. medical centers during 2010-2011
    Gary V Doern
    Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Antimicrob Agents Chemother 56:3406-8. 2012
    ..Among the isolates characterized in this investigation, 38.9% were found to be nonsusceptible to penicillin (oral penicillin breakpoints) and 9.1% were nonsusceptible to ceftriaxone (nonmeningitis breakpoints)...
  40. pmc Phenotypic and molecular analysis of penicillin-nonsusceptible Streptococcus pneumoniae isolates in Poland
    Ewa Sadowy
    Department of Molecular Microbiology, National Institute of Public Health, ul Chełmska 30 34, 00 725 Warsaw, Poland
    Antimicrob Agents Chemother 51:40-7. 2007
    ..The spread of Spain(9V)-3 and its related clone of serotype 14/ST143 has remarkably contributed to the recent increase in penicillin resistance in pneumococci in the country...
  41. ncbi Penicillin skin testing in advance of need: multiyear follow-up in 568 test result-negative subjects exposed to oral penicillins
    Eric Macy
    Departments of Allergy and Research and Evaluation, Kaiser Permanente Southern California, and the Department of Allergy and Immunology, University of California at San Diego, Calif, USA
    J Allergy Clin Immunol 111:1111-5. 2003
    ....
  42. ncbi Diagnosis and management of adults with pharyngitis. A cost-effectiveness analysis
    Joan M Neuner
    Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Ann Intern Med 139:113-22. 2003
    ..However, little is known about the effectiveness or cost-effectiveness of various strategies for managing pharyngitis caused by group A beta-hemolytic streptococcus (GAS) in U.S. adults...
  43. ncbi The complex clinical picture of beta-lactam hypersensitivity: penicillins, cephalosporins, monobactams, carbapenems, and clavams
    Maria J Torres
    Allergy Service, Plaza del Hospital Civil, Pabellón 5 Sótano, Carlos Haya Hospital, Pabellon C, Malaga 29009, Spain
    Med Clin North Am 94:805-20, xii. 2010
    ..The natural history of IgE-mediated reactions indicates that the count of specific IgE antibodies decreases over time and that results of diagnostic tests can become negative...
  44. ncbi Regulation of inducible AmpC beta-lactamase expression among Enterobacteriaceae
    N D Hanson
    Center for Research in Anti Infectives and Biotechnology, Departments of Pediatrics and Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Curr Pharm Des 5:881-94. 1999
    ..In doing so, the genes and gene products required for the process of AmpC induction are described. In addition, we review the data addressing cell wall recycling as it relates to AmpC induction...
  45. ncbi Effects of antibiotics and steroid on middle ear mucosa in rats with experimental acute otitis media
    S N Park
    Department of Otolaryngology-Head and Neck Surgery, Kangnam St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Seocho-gu, Seoul, South Korea
    Acta Otolaryngol 121:808-12. 2001
    ....
  46. pmc Sensitivity of amoxicillin-resistant Helicobacter pylori to other penicillins
    M P Dore
    Department of Medicine, VA Medical Center, and Baylor College of Medicine, Houston, Texas 77030, USA
    Antimicrob Agents Chemother 43:1803-4. 1999
    The sensitivities to penicillins and to a penicillin and beta-lactamase inhibitor combination agent were determined for Helicobacter pylori strains that were sensitive, moderately resistant, or highly resistant to amoxicillin...
  47. ncbi Frequent resistance of clinical group B streptococci isolates to clindamycin and erythromycin
    M D Pearlman
    Department of Obstetrics and Gynecology, The University of Michigan Health System, Ann Arbor 48109 0276, USA
    Obstet Gynecol 92:258-61. 1998
    ..To determine both the frequency of reported penicillin allergy in parturients and the frequency of resistance in vitro of clinical isolates of group B streptococci to clindamycin and erythromycin...
  48. pmc Penicillin for acute sore throat in children: randomised, double blind trial
    Sjoerd Zwart
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Stratenum 6 131, PO Box 85060, 3508 AB Utrecht, Netherlands
    BMJ 327:1324. 2003
    ..To assess the effectiveness of penicillin for three days and treatment for seven days compared with placebo in resolving symptoms in children with sore throat...
  49. ncbi Core promoters of the penicillin biosynthesis genes and quantitative RT-PCR analysis of these genes in high and low production strain of Penicillium chrysogenum
    R Smidák
    Institute of Molecular Biology, Slovak Academy of Sciences, 845 51, Bratislava 45, Slovak Republic
    Folia Microbiol (Praha) 55:126-32. 2010
    ....
  50. ncbi Specific serum IgE levels and FcepsilonRIbeta genetic polymorphism in patients with penicillins allergy
    H L Qiao
    Department of Clinical Pharmacology, School of Medicine, Zhengzhou University, Zhengzhou, China
    Allergy 59:1326-32. 2004
    ..The objective of this investigation is to elucidate the underlying mechanism of penicillins allergy and improve the diagnostic methods.
  51. ncbi Potential transition state analogue inhibitors for the penicillin-binding proteins
    Aleksandr Pechenov
    Division of Pharmaceutical Sciences, University of Missouri Kansas City, 5005 Rockhill Road, Kansas City, Missouri 64110, USA
    Biochemistry 42:579-88. 2003
    ....
  52. ncbi Penicillin at the late stage of leptospirosis: a randomized controlled trial
    Everaldo Costa
    Escola Bahiana de Medicina e Saude Publica, Salvador, BA, Brasil
    Rev Inst Med Trop Sao Paulo 45:141-5. 2003
    ..Therefore, more attention should be directed to prevention and earlier initiation of the treatment of leptospirosis...
  53. ncbi Substrate specificity of penicillin acylase from Streptomyces lavendulae
    Raquel Torres-Guzmán
    Departamento de Bioquimica y Biologia Molecular, Universidad Complutense, Madrid, 28040, Spain
    Biochem Biophys Res Commun 291:593-7. 2002
    ..The enzyme hydrolyses phenoxymethyl penicillin (penicillin V) and other penicillins with aliphatic acyl-chains such as penicillin F, dihydroF, and K...
  54. ncbi Industrial production of beta-lactam antibiotics
    R P Elander
    Biotechnology Consultant, 318 Gravilla Street, La Jolla, CA 92037 6006, USA
    Appl Microbiol Biotechnol 61:385-92. 2003
    ..Today, the beta-lactam antibiotics, particularly penicillins and cephalosporins, represent the world's major biotechnology products with worldwide dosage form sales of ..
  55. ncbi Longer-duration uses of tetracyclines and penicillins in U.S. food-producing animals: Indications and microbiologic effects
    Jeremy J Mathers
    Alpharma, LLC, Chicago Heights, IL 60411 USA
    Environ Int 37:991-1004. 2011
    ..and analyze regulatory categories for longer duration of use (defined as ≥ 7 day) tetracyclines (TCs) and penicillins (PNs) approved for U.S...
  56. ncbi The use of cephalosporins in penicillin-allergic patients: a literature review
    James D Campagna
    Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Emerg Med 42:612-20. 2012
    ..The practice of avoiding cephalosporin administration to penicillin-allergic patients persists despite the low rate of cross reactions between both groups of antibiotics...
  57. ncbi An open, randomized, controlled trial of penicillin, doxycycline, and cefotaxime for patients with severe leptospirosis
    Yupin Suputtamongkol
    Department of Medicine, Faculty of Medicine at Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 39:1417-24. 2004
    ..Although leptospirosis generally is susceptible to antibiotics, there is no consensus regarding the optimal treatment for severe leptospirosis...
  58. ncbi Antibiotic susceptibility and molecular epidemiology of nasopharyngeal pneumococci from Spanish children
    D Sanchez-Tatay
    Fundación Reina Mercedes, Hospital Universitario Virgen del Rocio, Sevilla
    Clin Microbiol Infect 14:797-801. 2008
    ....
  59. pmc Nonlinear biosynthetic gene cluster dose effect on penicillin production by Penicillium chrysogenum
    Jeroen G Nijland
    Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, Zernike Institute for Advanced Materials, Centre for Synthetic Biology, and Kluyver Centre for Genomics of Industrial Fermentation, University of Groningen, Kerklaan 30, 9751 NN Haren, Netherlands
    Appl Environ Microbiol 76:7109-15. 2010
    ..These results suggest that at a high penicillin production level, productivity is limited by the peroxisomal acyltransferase import activity and/or the availability of coenzyme A (CoA)-activated side chains...
  60. ncbi Evaluation of penicillin therapy in patients with leptospirosis and acute renal failure
    E F Daher
    Departamento de Medicina Clinica, Hospital Universitario Walter Cantidio, Faculdade de Medicina, Universidade Federal do Ceara, Fortaleza, CE, Brasil
    Rev Inst Med Trop Sao Paulo 42:327-32. 2000
    ..Dialytic treatment indication and mortality were similar between group T and nT. In conclusion, penicillin therapy did not provide better clinical outcome in patients with leptospirosis and ARF...
  61. ncbi Reactivity of penicillin-binding proteins with peptidoglycan-mimetic beta-lactams: what's wrong with these enzymes?
    Helen R Josephine
    Department of Chemistry, Wesleyan University, Middletown, Connecticut 06459, USA
    Biochemistry 45:15873-83. 2006
    ..these experiments is expanded in the present paper where we describe the synthesis of a series of beta-lactams (penicillins and cephalosporins) containing peptidoglycan-mimetic side chains and the kinetics of their inhibition of a ..
  62. ncbi The perfect penicillin? Inhibition of a bacterial DD-peptidase by peptidoglycan-mimetic beta-lactams
    Helen R Josephine
    Department of Chemistry, Wesleyan University, Lawn Avenue, Middletown, CT 06459, USA
    J Am Chem Soc 126:8122-3. 2004
    ..This result has interesting implications for beta-lactam design...
  63. ncbi A characteristic time sequence of epileptic activity in EEG during dynamic penicillin-induced focal epilepsy--a preliminary study
    Minna J Silfverhuth
    WellTech Oulu Institute, University of Oulu, Department of Electrical and Information Engineering, Linnanmaa, University of Oulu, Oulu, Finland
    Seizure 20:513-9. 2011
    ..Morphological evolution does not appear to follow a clear continuum; rather, intermingled and variable spike or multispike waveforms generally lead to stabilised activity of high-amplitude monophasic spikes...
  64. pmc Reproductive performance, udder health, and antibiotic resistance in mastitis bacteria isolated from Norwegian Red cows in conventional and organic farming
    Randi T Garmo
    Norwegian School of Veterinary Science, Department of Production Animal Clinical Sciences, NO 0033 Oslo, Norway
    Acta Vet Scand 52:11. 2010
    ....
  65. ncbi IgE-mediated hypersensitivity to cephalosporins: cross-reactivity and tolerability of penicillins, monobactams, and carbapenems
    Antonino Romano
    Allergy Unit, Complesso Integrato Columbus, Rome, Italy
    J Allergy Clin Immunol 126:994-9. 2010
    There have been few studies regarding the cross-reactivity and tolerability of penicillins, aztreonam, and carbapenems in large samples of subjects with cephalosporin allergy.
  66. ncbi Role of beta-lactam carboxyl group on binding of penicillins and cephalosporins to class C beta-lactamases
    Cristina Fenollar-Ferrer
    Departament de Quimica, Universitat de les Illes Balears, Palma de Mallorca, Spain
    Proteins 51:442-52. 2003
    ..based on the AMBER force field, to examine the molecular differentiation mechanisms between cephalosporins and penicillins in beta-lactamases...
  67. ncbi Dynamic gene expression regulation model for growth and penicillin production in Penicillium chrysogenum
    Rutger D Douma
    Department of Biotechnology, Delft University of Technology, Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, 2628 BC Delft, The Netherlands
    Biotechnol Bioeng 106:608-18. 2010
    ....
  68. ncbi Pneumococcal meningitis in the intensive care unit: prognostic factors of clinical outcome in a series of 80 cases
    Marc Auburtin
    Medical Intensive Care Unit, Microbiology Laboratory, Hospital Bichat Claude Bernard, 46 rue Henri Huchard, Paris, France
    Am J Respir Crit Care Med 165:713-7. 2002
    ..pneumoniae meningitis, hyperventilation should be used with caution. Nonsusceptibility to penicillin G is not associated with a worse outcome. High-dose corticosteroids may be beneficial in the most severely ill patients...
  69. pmc Peroxisomes are required for efficient penicillin biosynthesis in Penicillium chrysogenum
    Wiebe H Meijer
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kluyver Centre for Genomics of Industrial Fermentation, P O Box 14, 9750 AA Haren, The Netherlands
    Appl Environ Microbiol 76:5702-9. 2010
    ..We observed that the organelle proliferation machinery requires the dynamin-like protein Dnm1...
  70. ncbi Matching the proteome to the genome: the microbody of penicillin-producing Penicillium chrysogenum cells
    Jan A K W Kiel
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, AA Haren, The Netherlands
    Funct Integr Genomics 9:167-84. 2009
    ..We show that this protein indeed localizes to P. chrysogenum microbodies...
  71. ncbi A metabolome study of the steady-state relation between central metabolism, amino acid biosynthesis and penicillin production in Penicillium chrysogenum
    Uly Nasution
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Metab Eng 10:10-23. 2008
    ....
  72. ncbi Has the licensing of respiratory quinolones for adults and the 7-valent pneumococcal conjugate vaccine (PCV-7) for children had herd effects with respect to antimicrobial non-susceptibility in invasive Streptococcus pneumoniae?
    A Fenoll
    Spanish National Reference Pneumococcal Laboratory, Instituto de Salud Carlos III, Ctra Majadahonda Pozuelo km 2, 28220 Majadahonda, Madrid, Spain
    J Antimicrob Chemother 62:1430-3. 2008
    ....
  73. ncbi Syphilitic uveitis: a review of clinical manifestations and treatment outcomes of syphilitic uveitis in human immunodeficiency virus-positive and negative patients
    Bhagya Chathri Amaratunge
    Royal Victorian Eye and Ear Hospital, East Melbourne, Australia
    Clin Experiment Ophthalmol 38:68-74. 2010
    ..Most received appropriate therapy with a low relapse rate, which was not related to the type of therapy...
  74. ncbi Resistant penicillin-binding proteins
    R Hakenbeck
    Institut fur Mikrobiologie, Universitat Kaiserslautern, Germany
    Cell Mol Life Sci 54:332-40. 1998
    ..Enterococci have a natural low susceptibility to beta-lactams related to the presence of an intrinsic low-affinity PBP. Highly resistant enterococcal strains overexpress this PBP and/or reduce its affinity...
  75. ncbi In vivo transport of the intermediates of the penicillin biosynthetic pathway in tailored strains of Penicillium chrysogenum
    Carlos García-Estrada
    Instituto de Biotecnologia INBIOTEC, Parque Cientifico de Leon, Av Real, 1, 24006, Leon, Spain
    Appl Microbiol Biotechnol 76:169-82. 2007
    ..The P. chrysogenum membrane permeability to exogenous benzylpenicillin was tested in the npe10 strain. Penicillin is absorbed by the cells by an unknown mechanism, but its intracellular concentration is kept low...
  76. ncbi Ceftriaxone compared with sodium penicillin g for treatment of severe leptospirosis
    Thanachai Panaphut
    Department of Medicine, Khon Kaen Hospital, Khon Kaen, Thailand
    Clin Infect Dis 36:1507-13. 2003
    ..Once-daily administration and the extended spectrum of ceftriaxone against bacteria provide additional benefits over intravenous penicillin...
  77. ncbi Reexamining syphilis: an update on epidemiology, clinical manifestations, and management
    Molly E Kent
    Department of Pharmacy, University of Maryland Medical Center, Baltimore, MD, USA
    Ann Pharmacother 42:226-36. 2008
    ..To review the epidemiology, clinical features, diagnosis, and treatment of syphilis...
  78. pmc Epidemiology of invasive meningococcal disease with decreased susceptibility to penicillin in Ontario, Canada, 2000 to 2006
    Elizabeth M Brown
    Ontario Agency for Health Protection and Promotion, Public Health Laboratories, 81 Resources Road, Toronto, Ontario, Canada M9P 3T1
    Antimicrob Agents Chemother 54:1016-21. 2010
    ..In contrast to trends of the 1990s, the incidence of IMD with DSP was stable in Ontario between 2000 and 2006. In Ontario, the serogroup rather than the penicillin MIC is the microbiological parameter most predictive of mortality...
  79. pmc Proteome analysis of the penicillin producer Penicillium chrysogenum: characterization of protein changes during the industrial strain improvement
    Mohammad Saeid Jami
    Area de Microbiologia, Departamento de Biologia Molecular, Universidad de Leon, Campus de Vegazana s n, 24071 Leon, Spain
    Mol Cell Proteomics 9:1182-98. 2010
    ..These results provide useful information to improve the production of many other bioactive secondary metabolites...
  80. pmc Outbreak of cefozopran (penicillin, oral cephems, and aztreonam)-resistant Neisseria gonorrhoeae in Japan
    T Muratani
    Department of Urology, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu, Japan
    Antimicrob Agents Chemother 45:3603-6. 2001
    ..Restriction fragment length polymorphism DNA typing revealed that the outbreak of cefozopran-resistant isolates in Kitakyushu, Japan, occurred as a result of clonal spread...
  81. ncbi Disruption of phacA, an Aspergillus nidulans gene encoding a novel cytochrome P450 monooxygenase catalyzing phenylacetate 2-hydroxylation, results in penicillin overproduction
    J M Mingot
    Departamento de Microbiologia Molecular, Centro de Investigaciones Biológicas del Consejo Superior de Investigaciones Científicas, Velazquez 144, Madrid, 28006, Spain
    J Biol Chem 274:14545-50. 1999
    ....
  82. ncbi Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutations
    A Dessen
    Laboratoire de Cristallographie Macromoléculaire, Institut de Biologie Structurale Jean Pierre Ebel CNRS Commissariat à l Energie Atomique, 41, rue Jules Horowitz, 38027 Grenoble, France
    J Biol Chem 276:45106-12. 2001
    Penicillin-binding proteins (PBPs) are the main targets for beta-lactam antibiotics, such as penicillins and cephalosporins, in a wide range of bacterial species...
  83. ncbi Fluorescent Bocillins: synthesis and application in the detection of penicillin-binding proteins
    K R Gee
    Molecular Probes, Inc, Eugene, OR 97402, USA
    Electrophoresis 22:960-5. 2001
    ..These reagents allow for facile detection of 2-4 ng of purified PBP with the aid of a fluorescent scanner...
  84. ncbi Is there cross-reactivity between penicillins and cephalosporins?
    Andrea J Apter
    Division of Pulmonary, Allergy Critical Care Medicine, Department of Medicine, Philadelphia, PA, USA
    Am J Med 119:354.e11-9. 2006
    ..We sought to determine the risk of an allergic reaction to a cephalosporin exposure in those with prior penicillin reactions...
  85. ncbi Overproduction of a single protein, Pc-Pex11p, results in 2-fold enhanced penicillin production by Penicillium chrysogenum
    Jan A K W Kiel
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, PO Box 14, NL 9750 AA Haren, The Netherlands
    Fungal Genet Biol 42:154-64. 2005
    ..Our results suggest that the stimulating effect of enhanced organelle numbers may reflect an increase in the fluxes of penicillin and/or its precursors across the now much enlarged microbody membrane...
  86. ncbi Antimicrobial susceptibilities of amoxycillin-non-susceptible and susceptible isolates among penicillin-non-susceptible Streptococcus pneumoniae
    E Perez-Trallero
    Department of Microbiology, Hospital Donostia, San Sebastian, Spain
    Clin Microbiol Infect 13:937-40. 2007
    ..Spain(14)-5 was the most problematic clone in terms of antibiotic resistance...
  87. pmc Correlation of oxacillin MIC with mecA gene carriage in coagulase-negative staphylococci
    Z Hussain
    London Health Sciences Centre, The University of Western Ontario, London, Ontario, Canada
    J Clin Microbiol 38:752-4. 2000
    ..6%) as methicillin resistant. The results of this study indicate that the new oxacillin breakpoint accurately identifies strains of CoNS with mecA but is not specific for strains of certain species of CoNS without mecA...
  88. pmc The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition
    Nuno Mendonça
    Antibiotic Resistance Unit, Department of Infectious Diseases, National Institute of Health Dr Ricardo Jorge Av Padre Cruz, 1649 016 Lisbon, Portugal
    Antimicrob Agents Chemother 52:1806-11. 2008
    ..SHV-72 had high catalytic efficiency against penicillins (k(cat)/K(m), 35 to 287 microM(-1) x s(-1)) and no activity against oxyimino beta-lactams...
  89. ncbi Ceftazidime-hydrolysing β-lactamase OXA-145 with impaired hydrolysis of penicillins in Pseudomonas aeruginosa
    Didier Hocquet
    Centre National de Référence de Résistance aux Antibiotiques, Laboratoire associé Pseudomonas aeruginosa, Centre Hospitalier Universitaire, Besancon, France
    J Antimicrob Chemother 66:1745-50. 2011
    ..The genetic environment of bla(OXA-145) and the biochemical properties of OXA-145 are reported. We also assessed the impact of the Leu-165 deletion on the hydrolysis spectrum of the ancestor OXA-10...
  90. ncbi Confirmatory assay for the simultaneous detection of penicillins and cephalosporins in milk using liquid chromatography/tandem mass spectrometry
    E Daeseleire
    Ministry of Small Enterprises, Traders and Agriculture, Agricultural Research Centre Ghent, Animal Product Quality and Transformation Technology, Brusselsesteenweg 370, 9090 Melle, Belgium
    Rapid Commun Mass Spectrom 14:1404-9. 2000
    ..liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for the detection of residues of penicillins and cephalosporins in milk has been developed...
  91. ncbi Incremental increase in fitness cost with increased beta -lactam resistance in pneumococci evaluated by competition in an infant rat nasal colonization model
    Krzysztof Trzcinski
    Department of Epidemiology and Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Infect Dis 193:1296-303. 2006
    ....
  92. ncbi Streamlining methodology for the multiresidue analysis of beta-lactam antibiotics in bovine kidney using liquid chromatography-tandem mass spectrometry
    Katerina Mastovska
    US Department of Agriculture, Agricultural Research Service, Eastern Regional Research Center, 600 East Mermaid Lane, Wyndmoor, PA 19038, USA
    J Chromatogr A 1202:118-23. 2008
    ..In this way, a blank solvent is injected after each sample, but these in-between injections contribute minimally to the overall sample throughput...
  93. ncbi Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children
    Marina Atanaskovic-Markovic
    Department of Allergology and Pulmonology, University Children s Hospital, Belgrade, Serbia and Montenegro
    Pediatr Allergy Immunol 16:341-7. 2005
    b>Penicillins and cephalosporins are the most important betalactams inducing IgE-mediated reactions...
  94. pmc A replica of Alexander Fleming's Nobel medal
    H W Gallagher
    The Ulster Community and Hospitals Trust, Upper Newtownards Road, Dundonald, Belfast
    Ulster Med J 75:153-4. 2006
  95. ncbi Imipenem in patients with immediate hypersensitivity to penicillins
    Antonino Romano
    N Engl J Med 354:2835-7. 2006
  96. ncbi High percentages of resistance to tetracycline and penicillin and reduced susceptibility to azithromycin characterize the majority of strain types of Neisseria gonorrhoeae isolates in Cuba, 1995-1998
    Jorge Sosa
    Instituto de Medicina Tropical Pedro Kouri, Havana, Cuba
    Sex Transm Dis 30:443-8. 2003
    ..The Gonococcal Antimicrobial Surveillance Program (GASP) in Cuba was established as part of a larger regional GASP program to facilitate the collection and reporting of antimicrobial susceptibility data for N gonorrhoeae isolates...
  97. ncbi Immediate allergic reactions to cephalosporins: evaluation of cross-reactivity with a panel of penicillins and cephalosporins
    Cristina Antunez
    Research Laboratory for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
    J Allergy Clin Immunol 117:404-10. 2006
    ..The problem of studying cross-reactivity in subjects primarily sensitized to cephalosporins and potentially allergic to penicillins has not been sufficiently addressed.
  98. pmc Outer membrane porin M35 of Moraxella catarrhalis mediates susceptibility to aminopenicillins
    Marion Jetter
    Institute for Infectious Diseases, University of Bern, CH 3010 Bern, Switzerland
    BMC Microbiol 9:188. 2009
    ..catarrhalis...
  99. ncbi Benzylpenicillin skin testing is still important in diagnosing immediate hypersensitivity reactions to penicillins
    A Romano
    Department of Internal Medicine and Geriatrics, UCSC Allergy Unit, Complesso Integrato Columbus, Rome, Italy
    Allergy 64:249-53. 2009
    ....
  100. ncbi Confirmatory and quantitative analysis of beta-lactam antibiotics in bovine kidney tissue by dispersive solid-phase extraction and liquid chromatography-tandem mass spectrometry
    Clifton K Fagerquist
    Western Regional Research Center, Agricultural Research Service, U S Department of Agriculture, Albany, California 94710, USA
    Anal Chem 77:1473-82. 2005
    ....
  101. ncbi Diagnostic evaluation of a large group of patients with immediate allergy to penicillins: the role of skin testing
    M J Torres
    Research Unit for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
    Allergy 56:850-6. 2001
    ..METHODS: Patients with a history of immediate allergic reactions to penicillins were studied with: skin tests with major and minor determinants of benzylpenicillin (BPO/MDM), amoxicillin, and ..

Research Grants72

  1. Cellular &Inflammatory Pathways in Ashtma &Allergic Diseases: From IgE to Cells
    LAWRENCE BARRY SCHWARTZ; Fiscal Year: 2012
    ..Understanding more precisely the characteristics of and the mechanism(s) behind desensitization will enable physicians to better utilize this approach to reduce mast cell/basophil-mediated contributions to asthma and allergic diseases. ..
  2. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    ....
  3. Development of a Novel PolC Inhibitor as a Gram-Positive Antibiotic
    THALE CROSS JARVIS; Fiscal Year: 2013
    ..This project represents a compelling opportunity to combat the rising tide of antibiotic-resistant infections, providing a much-needed public health benefit. ..
  4. Functional Consequence of Macrolide Resistance Mutations in T. pallidum
    Sheila A Lukehart; Fiscal Year: 2012
    ..If these mutations are found to be common and are shown to cause treatment failure, physicians will be advised not to use azithromycin for treating patients with syphilis. ..
  5. Cell wall synthesis enzymes and beta-lactam resistance in Enterococcus faecium
    Louis B Rice; Fiscal Year: 2013
    ..They will also enhance our understanding of cell wall synthesis mechanisms in Gram-positive cocci and reveal promising new targets for antibacterial therapy. ..
  6. Gonococcal Mechanisms to Evade Host Defenses
    WILLIAM MAURICE SHAFER; Fiscal Year: 2013
    ..With more female veterans using the Medical Service as their primary mode of care, it is likely that VA Medical Centers will experience the health care costs associated with invasive gonococcal infections. ..
  7. Control of bacterial morphology and differentiation
    Yves V Brun; Fiscal Year: 2013
    ..Insights gained from these studies can be used to design strategies to inhibit growth, prevent key morphological changes, or alter important protein localization pathways in pathogens, thereby improving our ability to control them. ..
  8. Peptidoglycan Biogenesis in Escherichia Coli
    Thomas G Bernhardt; Fiscal Year: 2013
    ....
  9. Preserving beta-lactam utility against pathogens producing all classes of beta-la
    LUIGI XERRI; Fiscal Year: 2012
    ..b-Lactam antibiotics, including penicillins, cephalosporins, monobactams and carbapenems, are the most widely used antibiotic class in the U.S...
  10. Overcoming Membrane Transporters to Improve CNS Drug Therapy
    Robert S B Clark; Fiscal Year: 2013
    ....
  11. Novel Mechanisms of Beta-lactam Resistance in Staph Aureus
    Henry F Chambers; Fiscal Year: 2013
    ..Recombinant GdpP also will be purified and analyzed by x-ray crystallography to identify its critical structural properties. Achieving these aims will increase knowledge of ?-lactam antibiotic effects and mechanisms of resistance. ..
  12. Peptidoglycan synthesis during sporulation
    Jonathan Dworkin; Fiscal Year: 2012
    ..We expect that new understanding of this process will lead to the development of new antibiotics. ..
  13. B-lactam mediated SOS response and expression of resistance in clinical MRSA
    Adriana E Rosato; Fiscal Year: 2013
    ....
  14. Elucidation of Antisickling Molecules in a Botanical with Antisickling Activity
    Robert Swift; Fiscal Year: 2013
    ..The active fractions will be further fractionated, the compounds in the sub-fractions identified using mass spectroscopy and NMR, and in vivo activity confirmed in 100% human Hb S transgenic mice. ..
  15. Duration of Intrapartum Antibiotic Prophylaxis for Group B Streptococcus
    Jessica L Illuzzi; Fiscal Year: 2010
    ..b>Penicillins enter the fetal bloodstream within minutes of administration to the mother and have been found to rapidly reach ..
  16. Supramolecular Complexes That Mediate Pneumococcal PG Biosynthesis and Virulence
    Malcolm E Winkler; Fiscal Year: 2012
    ....
  17. First Clinical Trial of an Anti-Sickling Botanical Drug for Sickle Cell Dise
    Robert Swift; Fiscal Year: 2013
    ....
  18. STAPHYLOCOCCAL METHICILLIN RESISTANCE LOCUS
    Gordon Archer; Fiscal Year: 2009
    ..Elucidation of these pathways may provide new targets for chemotherapy and new strategies for treatment. ..
  19. Molecular Targets in Peptidoglycan Synthesis
    Christopher Davies; Fiscal Year: 2013
    ..To understand the functional role of AmiC in peptidoglycan breakdown, but also to pave the way for drug discovery against its two active sites, we will obtain essential structural and biochemical information for AmiC. ..
  20. Systematic Phenotypic Analysis of the Gram-positive Envelope
    Jason M Peters; Fiscal Year: 2013
    ..subtilis. The discoveries made in this study will likely extend to important Gram-positive human pathogens, as well as human commensals in the gut microbiome. ..
  21. Molecular analysis of oriT-independent transfer in the gonococcal R-plasmids
    LUIS TORRES-BAUZA; Fiscal Year: 2012
    ..This research will help to design innovative methods to control the horizontal transmission of resistance plasmids among bacteria. ..
  22. NMR studies of heterocyclization and epimerization in yersiniabactin synthesis
    DOMINIQUE PASCAL FRUEH; Fiscal Year: 2013
    ....
  23. Developing a rapid agglutination assay for MRSA.
    NILES PATRICK DONEGAN; Fiscal Year: 2012
    ..aureus. Successful conclusion of clinical studies will justify an application to the FDA-CLIA for approval of the diagnostic kit. ..
  24. Preserving beta-lactam utility vs pathogens producing any class of beta-lactamase
    LUIGI XERRI; Fiscal Year: 2013
    ..NDM-1 hydrolyzes all subclasses of [unreadable]-lactams (penicillins, cephalosporins and carbapenems) with the exception of monobactams (e.g., Aztreonam)...
  25. GONOCOCCAL INFECTION AND GENE EXPRESSION IN FEMALE MICE
    Ann E Jerse; Fiscal Year: 2013
    ..Finally, phosphorothiorate- modified antisense oligo-deoxynucleotides (PS-ODNs) that target the mtrC transcript will be tested as a potential therapy for increasing Gc susceptibility to APs, antibiotics, and PMN killing. ..
  26. STAPHYLOCOCCAL METHICILLIN RESISTANCE LOCUS
    GORDON LEE ARCHER; Fiscal Year: 2013
    ..In addition, it will investigate conditions that promote the loss of this gene that may suggest strategies for reducing the hospital prevalence of MRSA. ..
  27. Molecular Analysis of Tuberculosis Immunity
    WILLIAM ROBERT JACOBS; Fiscal Year: 2013
    ..Project 4 (J. Blanchard, Pl) will explore the enzymological basis for resistance to penicillins, and refine a novel therapy that employs meropenums and beta-lactamase inhibitors that is potentially highly ..
  28. Cranberry: Interactions with Anti-infectious Agents
    Gail Anderson; Fiscal Year: 2005
    ..pathogens in UTI are typically responsive to trimethoprim-sulfamethoxazole, quinolones, and the beta-lactams (penicillins, cephalosporins)...
  29. Lumbar Puncture and Syphilis Outcome
    Christina M Marra; Fiscal Year: 2013
    ..Hypothesis: the No LP group, which includes undiagnosed and untreated NS patients, will have less improvement in cognition and function after therapy than the LP group. ..
  30. Novel Compounds Targeting Bacterial PBPs
    LUIGI XERRI; Fiscal Year: 2013
    ..Such new products could serve as a critical advance in the search for new treatments for serious multi-resistant bacterial infections in the nosocomial and community settings. ..
  31. Obstetric Pharmacology Research Units Network Center at UTMB-Galveston
    Gary D Hankins; Fiscal Year: 2013
    ....
  32. Bacterial cell wall synthesis, shape and septation
    Kevin D Young; Fiscal Year: 2013
    ..The work will also serve as a model for similar morphological investigations in other organisms. ..
  33. BETA LACTAMASE MUTATIONS IN ANTIBIOTIC RESISTANCE
    Timothy Palzkill; Fiscal Year: 2013
    ..The ?-lactam antibiotics, such as the penicillins and cephalosporins, are among the most often used antimicrobials...
  34. Identification small molecule inhibitors of the bacterial morphogenetic complex
    JAMES GOBER; Fiscal Year: 2009
    ....
  35. High-Spin Iron(IV)-oxo Complexes-True Mimics of Enzymatic Non-Heme Iron
    AIDAN RICHARD MCDONALD; Fiscal Year: 2010
    ..Ultimately this will allow us to more efficiently develop medicines to treat certain illnesses, and for the 'clean'natural removal of toxins from the environment. ..
  36. Modulation of Virulence Determinants Contributing to Gonococcal Pathogenesis
    Daniel Williams; Fiscal Year: 2010
    ....
  37. GONOCOCCAL INFECTION AND GENE EXPRESSION IN FEMALE MICE
    ANN JERSE; Fiscal Year: 2009
    ..Finally, phosphorothiorate-modified antisense oligodeoxynucleotides (PS-ODNs) that target the mtrC transcript will be tested as a potential therapy for increasing Gc susceptibility to APs, antibiotics, and PMN killing. ..
  38. Therapeutics for Drug-Resistant Bacteria: Pseudouridimycins
    Richard H Ebright; Fiscal Year: 2013
    ..Analogs of high promise will be evaluated for antibacterial efficacy in small-animal models of infection, and analogs of highest promise will be evaluated for bioavailability, pharmacokinetics, safety, and ability to scale synthesis. ..
  39. Redesign of the Carbapenem Scaffold
    Bret M Benton; Fiscal Year: 2012
    ..In general, carbapenemases have extremely broad substrate specificity, hydrolyzing penicillins, cephalosporins, carbapenems, and often even monobactams...
  40. Accessing Natural Products from Silent Biosynthetic Pathways
    ROBERT HENRY CICHEWICZ; Fiscal Year: 2012
    ..g., penicillins, echinocandins, cyclosporins, ergot alkaloids, and statins)...
  41. Developing and Testing a Novel Geometric Model of Protein Adaptation
    DANIEL MICHAEL WEINREICH; Fiscal Year: 2013
    ..abstract_text> ..
  42. Role of Signal Transduction in Resistance to Cell-Wall Antimicrobials in MRSA
    ROBERT S contact DAUM; Fiscal Year: 2010
    ..new antimicrobials to treat MRSA isolates that are resistant to all available ss-lactam antibiotics including penicillins and cephalosporins...
  43. Yogurt beverages as a vehicle to deliver high dose probiotics
    Daniel J Merenstein; Fiscal Year: 2013
    ..abstract_text> ..
  44. Novel Mechanisms of Beta-lactam Resistance in Staph Aureus
    Binh An Diep; Fiscal Year: 2012
    ..The overall goal of the proposed research is to define the molecular basis for mecA-independent resistance to ?-lactams, which could lead to a better understanding of ?-lactam antibiotic effects and identification of novel drug targets. ..
  45. BIOSYNTHESIS OF BETA-LACTAM ANTIBIOTICS
    CRAIG ARTHUR TOWNSEND; Fiscal Year: 2013
    ..abstract_text> ..
  46. LpxC inhibitors as a novel class of antibiotics against N. gonorrhoeae
    Pei Zhou; Fiscal Year: 2013
    ..Successful completion of this proposal has the potential to develop a new class of antibiotics that target an unexploited essential pathway in Gram-negative bacteria. ..
  47. Novel Metallo-beta-lactamase Inhibitors
    LUIGI XERRI; Fiscal Year: 2012
    ..e. penicillins, cephalosporins, carbapenems) both in hospital and community settings1,5,6...
  48. SNPs in Handling of Small Pox Antivirals and Other Drugs
    Sanjay Nigam; Fiscal Year: 2009
    At physiological pH, many drugs (eg. penicillins, NSAIDs, methotrexate, thiazides) exist as organic anions and are eliminated via the kidney proximal tubule through multispecific renal organic anion transporters (especially OAT1 and OAT3)..
  49. Overcoming O2 limitations: Reaction of Oxygenases with in situ generated O2
    BENNETT RICHARD STREIT; Fiscal Year: 2013
    ..Through the work of this proposal we will undoubtedly shine light onto the workings of these enzymatic systems thus giving important clues into the role of Fe-oxo species in these reactions of significant biological importance. ..
  50. Biosynthesis of Antifungal Lipopeptides from Filamentous Fungi
    Yi Tang; Fiscal Year: 2013
    ....
  51. PREVENTION OF ULCER HEMORRHAGE BY H PYLORI ERADICATION
    Dennis Jensen; Fiscal Year: 2000
    ....
  52. Immune Dysregulation in HIT
    Gowthami M Arepally; Fiscal Year: 2010
    ..It is expected that these studies will lead to insights into strategies that prevent or modulate immune complications from this life-threatening thrombotic disorder. ..
  53. ArmR: a novel drug target and mediator of antibiotic resistance
    David S Weiss; Fiscal Year: 2013
    ..We hypothesize that inhibition of ArmR would reverse the resistance to polymyxins, preserving their utility in the clinic, and also sensitize the bacteria to innate host defenses. ..
  54. Development of Protein-Based Beta-lactam Antibiotic Resistance Diagnostics
    Timothy Palzkill; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): ?-lactam antibiotics such as the penicillins and cephalosporins are the most often used antibiotics and account for more than 60% of total world consumption of antimicrobials...
  55. Roles of Mast Cells in Inflammatory Pain
    Devavani Chatterjea; Fiscal Year: 2010
    ..Resolving the potential role/s for mast cells in nociception will enhance our understanding of pain processes and provide knowledge about a novel aspect of mast cell physiology. ..
  56. Inducible Antibiotic Resistance in Methicillin-Resistant Staphylococcus Aureus
    Shahriar Mobashery; Fiscal Year: 2013
    ..Furthermore, we propose to study antibiotic resistance mechanisms that arise by alterations in the allosteric site. ..
  57. BETA LACTAMASE MUTATIONS IN ANTIBIOTIC RESISTANCE
    Timothy Palzkill; Fiscal Year: 2010
    ..of this phenomenon is the development of resistance to p-lactam antibiotics, p-lactam antibiotics, such as the penicillins and cephalosporins, are among the most frequently used antimicrobialagents...
  58. Mechanistic studies on peptidoglycan tailoring that mediate biofilm stability
    MATTHEW DENNIS LEBAR; Fiscal Year: 2013
    ..Demonstrating biofilm regulation by PBPs will allow for the development of new strategies toward treatment of biofilm related infections. ..
  59. Elucidating beta-lactamase functional mechanisms via evolutionary conservation
    Dennis R Livesay; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Penicillins and chemically related molecules are our most abundant and common used class of antibiotics, which are characterized by a conserved 4-atom [unreadable]-lactam ring...
  60. Mechanistic studies and inhibition strategies for antibiotic resistance
    Focco van den Akker; Fiscal Year: 2010
    ..in large part due to the bacterial expression of beta-lactamases that degrade beta-lactam antibiotics including penicillins, cephalosporins, and the "last resort" carbapenem antibiotics...
  61. Cell-Wall Recycling and Antibiotic Resistance
    Shahriar Mobashery; Fiscal Year: 2013
    ....
  62. Structure, Function and Inhibition of Beta-lactamases
    Brian K Shoichet; Fiscal Year: 2013
    ..A second is to exploit this information to discover novel inhibitors to escape the current cycle of incremental antibiotic modification followed by rapid resistance response. ..
  63. Impact of Antibiotics and Vaccines on the in vivo Evolution of S. pneumoniae
    Garth D Ehrlich; Fiscal Year: 2010
    ..WGS will be used to test if the emergence of these strains from minority to majority status in the nasopharynx and from colonizers to disease causing strains [unreadable] is accompanied by changes in genetic makeup ..
  64. Defining the bacterial factors that modulate sensitivity to B-lactam in CA-MRSA
    AMBROSE LIN YAU CHEUNG; Fiscal Year: 2010
    ..There are genes in CA-MRSA involved in this oxacillin sensitivity upon deletion of the pbp4 gene. Our goal is to identify and characterize these genes that confer oxacillin sensitivity. ..
  65. PENICILLIN RESPONSE GENES IN DRUG-RESISTANT PNEUMOCOCCI
    Alexander Tomasz; Fiscal Year: 1999
    ..The studies should also allow novel insights into as yet unexplored areas of the molecular biology and genetics of cell wall synthesis in pneumococci and other bacteria. ..
  66. REACTIVITY MODELS FOR ISOPENICILLIN N SYNTHETASE
    PATRICIA SHAPLEY; Fiscal Year: 1992
    Beta-Lactam antibiotics, including the penicillins, cephalosporins and monobactams, are very important in the treatment of bacterial infections...
  67. METHICILLIN RESISTANCE OF STAPHYLOCOCCUS AUREUS
    Henry Chambers; Fiscal Year: 1993
    ..Factors controlling expression of methicillin resistance and mechanisms responsible for penicillin effects may be better understood as a result of these studies...
  68. REGULATION OF BETA-LACTAMASE IN STAPHYLOCOCCUS AUREUS
    Corinne Hackbarth; Fiscal Year: 2000
    ..aureus beta-lactamase regulatory system using construction of uninducible and constitutive mutants. ..
  69. Genetic Basis of Virulence of Community MRSA Clone USA300
    Henry F Chambers; Fiscal Year: 2010
    ..By knocking each of these genes out and testing for loss of virulence, we hope to learn which genes code for virulence. Once these genes are identified, strategies to block their effects may be developed. ..
  70. Pilot study of Newborn screening for hemoglobinopathies in South Gujarat India
    Lakshmanan Krishnamurti; Fiscal Year: 2009
    ....
  71. H. INFLUENZAE: PENICILLIN BINDING PROTEINS & CELL WALL
    Paul Mendelman; Fiscal Year: 1991
    ....
  72. PENICILLIN INTERACTIVE PROTEINS OF STAPHYLOCOCCUS AUREUS
    Henry Chambers; Fiscal Year: 2003
    ..They are multiple drug resistant, but ineffectiveness of penicillins and beta-lactam antibiotics is the real problem, as these are drug of choice to treat staphylococcal infections...