hydrochlorothiazide

Summary

Summary: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It has been used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.

Top Publications

  1. ncbi Differential effects between a calcium channel blocker and a diuretic when used in combination with angiotensin II receptor blocker on central aortic pressure in hypertensive patients
    Yoshio Matsui
    Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, 3311 1 Yakushiji, Shimotsuke, Tochigi, Japan
    Hypertension 54:716-23. 2009
  2. ncbi Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients
    Kenneth Jamerson
    Division of Cardiovascular Medicine, University of Michigan Health System, 24 Frank Lloyd Wright Dr, Lobby M, Ann Arbor, MI 48106, USA
    N Engl J Med 359:2417-28. 2008
  3. ncbi Principal results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trial
    Henry R Black
    Rush Medical College of Rush University, Chicago, IL 60612, USA
    JAMA 289:2073-82. 2003
  4. ncbi Beneficial effects of eplerenone versus hydrochlorothiazide on coronary circulatory function in patients with diabetes mellitus
    Hylton V Joffe
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 92:2552-8. 2007
  5. ncbi Combination of amlodipine plus angiotensin receptor blocker or diuretics in high-risk hypertensive patients: a 96-week efficacy and safety study
    Liyuan Ma
    Department of Evidence Based Medicine, Cardiovascular Institute, Beijing, China
    Am J Cardiovasc Drugs 12:137-42. 2012
  6. ncbi The influence of cardiovascular and antiinflammatory drugs on thiazide-induced hemodynamic and saluretic effects
    H Knauf
    Department of Medicine 1, St Berward Krankenhaus, Hildesheim, Germany
    Eur J Clin Pharmacol 62:885-92. 2006
  7. pmc Pharmacogenomics of antihypertensive drugs: rationale and design of the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) study
    Julie A Johnson
    University of Florida College of Pharmacy and Center for Pharmacogenomics, Gainesville, USA
    Am Heart J 157:442-9. 2009
  8. ncbi Efficacy and tolerability of initial therapy with single-pill combination telmisartan/hydrochlorothiazide 80/25 mg in patients with grade 2 or 3 hypertension: a multinational, randomized, double-blind, active-controlled trial
    Dingliang L Zhu
    Shanghai Ruijin Hospital, Shanghai Institute of Hypertension, 197 Ruijin 2nd Road, Shanghai, China
    Clin Ther 34:1613-24. 2012
  9. pmc Spironolactone and hydrochlorothiazide exert antioxidant effects and reduce vascular matrix metalloproteinase-2 activity and expression in a model of renovascular hypertension
    C S Ceron
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Br J Pharmacol 160:77-87. 2010
  10. ncbi The efficacy and safety of low- and high-dose fixed combinations of irbesartan/hydrochlorothiazide in patients with uncontrolled systolic blood pressure on monotherapy: the INCLUSIVE trial
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    J Clin Hypertens (Greenwich) 7:578-86. 2005

Detail Information

Publications338 found, 100 shown here

  1. ncbi Differential effects between a calcium channel blocker and a diuretic when used in combination with angiotensin II receptor blocker on central aortic pressure in hypertensive patients
    Yoshio Matsui
    Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, 3311 1 Yakushiji, Shimotsuke, Tochigi, Japan
    Hypertension 54:716-23. 2009
    ..received olmesartan monotherapy for 12 weeks, followed by additional use of azelnidipine (n=103) or hydrochlorothiazide (n=104) for 24 weeks after randomization...
  2. ncbi Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients
    Kenneth Jamerson
    Division of Cardiovascular Medicine, University of Michigan Health System, 24 Frank Lloyd Wright Dr, Lobby M, Ann Arbor, MI 48106, USA
    N Engl J Med 359:2417-28. 2008
    ....
  3. ncbi Principal results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trial
    Henry R Black
    Rush Medical College of Rush University, Chicago, IL 60612, USA
    JAMA 289:2073-82. 2003
    ..Hypertensive patients are often given a calcium antagonist to reduce cardiovascular disease risk, but the benefit compared with other drug classes is controversial...
  4. ncbi Beneficial effects of eplerenone versus hydrochlorothiazide on coronary circulatory function in patients with diabetes mellitus
    Hylton V Joffe
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 92:2552-8. 2007
    ..Aldosterone causes cardiovascular injury and is not suppressed by chronic angiotensin converting enzyme (ACE) inhibitor therapy...
  5. ncbi Combination of amlodipine plus angiotensin receptor blocker or diuretics in high-risk hypertensive patients: a 96-week efficacy and safety study
    Liyuan Ma
    Department of Evidence Based Medicine, Cardiovascular Institute, Beijing, China
    Am J Cardiovasc Drugs 12:137-42. 2012
    ..the long-term efficacy and safety of two antihypertensive regimens, amlodipine plus telmisartan and amlodipine plus amiloride/hydrochlorothiazide, in patients with essential hypertension and at least one cardiovascular risk factor.
  6. ncbi The influence of cardiovascular and antiinflammatory drugs on thiazide-induced hemodynamic and saluretic effects
    H Knauf
    Department of Medicine 1, St Berward Krankenhaus, Hildesheim, Germany
    Eur J Clin Pharmacol 62:885-92. 2006
    ..Cardiovascular and antiinflammatory therapeutics may interfere with TGF and thereby influence the effect of thiazides once co-administration is clinically indicated...
  7. pmc Pharmacogenomics of antihypertensive drugs: rationale and design of the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) study
    Julie A Johnson
    University of Florida College of Pharmacy and Center for Pharmacogenomics, Gainesville, USA
    Am Heart J 157:442-9. 2009
    ..Selection of antihypertensive therapy is often empiric, and use of genetic information to guide drug therapy selection holds future promise...
  8. ncbi Efficacy and tolerability of initial therapy with single-pill combination telmisartan/hydrochlorothiazide 80/25 mg in patients with grade 2 or 3 hypertension: a multinational, randomized, double-blind, active-controlled trial
    Dingliang L Zhu
    Shanghai Ruijin Hospital, Shanghai Institute of Hypertension, 197 Ruijin 2nd Road, Shanghai, China
    Clin Ther 34:1613-24. 2012
    ..Patients with grade 2 or 3 hypertension may require high-dose combination therapy to achieve blood pressure (BP) targets in a timely manner...
  9. pmc Spironolactone and hydrochlorothiazide exert antioxidant effects and reduce vascular matrix metalloproteinase-2 activity and expression in a model of renovascular hypertension
    C S Ceron
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Br J Pharmacol 160:77-87. 2010
    ..We examined whether treatment with spironolactone (SPRL), hydrochlorothiazide (HCTZ) or both drugs together modified hypertension-induced changes in arterial blood pressure, aortic ..
  10. ncbi The efficacy and safety of low- and high-dose fixed combinations of irbesartan/hydrochlorothiazide in patients with uncontrolled systolic blood pressure on monotherapy: the INCLUSIVE trial
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    J Clin Hypertens (Greenwich) 7:578-86. 2005
    This multicenter, prospective, open-label, single-arm study determined the efficacy and safety of irbesartan/hydrochlorothiazide (HCTZ) fixed combinations in patients (n=1005), aged 18 years and older, with uncontrolled systolic blood ..
  11. pmc Efficacy and safety of fixed combinations of irbesartan/hydrochlorothiazide in hypertensive women: the inclusive trial
    Elizabeth O Ofili
    Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    J Womens Health (Larchmt) 17:931-8. 2008
    This post hoc analysis of the Irbesartan/Hydrochlorothiazide Blood Pressure Reductions in Diverse Patient Populations (INCLUSIVE) trial evaluated the efficacy and safety of irbesartan/hydrochlorothiazide (HCTZ) in a diverse population of ..
  12. ncbi A titrate-to-goal study of switching patients uncontrolled on antihypertensive monotherapy to fixed-dose combinations of amlodipine and olmesartan medoxomil ± hydrochlorothiazide
    Matthew R Weir
    University of Maryland School of Medicine, Baltimore, MD, USA
    J Clin Hypertens (Greenwich) 13:404-12. 2011
    ..Patients were subsequently uptitrated every 4 weeks to AML/OM+hydrochlorothiazide (HCTZ) 10/40+12.5 mg and 10/40+25 mg to achieve BP <125/75 mm Hg...
  13. pmc Long-term efficacy of a combination of amlodipine and olmesartan medoxomil ± hydrochlorothiazide in patients with hypertension stratified by age, race and diabetes status: a substudy of the COACH trial
    S Oparil
    Division of Cardiovascular Diseases, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294 0007, USA
    J Hum Hypertens 24:831-8. 2010
    ..safety of the combination of amlodipine (AML) + olmesartan medoxomil (OM), with and without the addition of hydrochlorothiazide (HCTZ), were investigated in patients aged ≥65 and <65 years, Blacks and non-Blacks and patients with ..
  14. ncbi Baseline characteristics in the Avoiding Cardiovascular events through Combination therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial: a hypertensive population at high cardiovascular risk
    Michael A Weber
    SUNY Downstate Medical College, 420 Lexington Avenue, Brooklyn, NY 10170, USA
    Blood Press 16:13-9. 2007
    ..non-fatal cardiovascular endpoints of two forms of antihypertensive combination therapy: benazepril plus hydrochlorothiazide and amlodipine plus benazepril in hypertensive patients at high cardiovascular risk...
  15. ncbi Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial
    Stevo Julius
    University of Michigan, Ann Arbor, USA
    Lancet 363:2022-31. 2004
    ....
  16. ncbi A pilot double-blind randomised placebo-controlled trial of the effects of fixed-dose combination therapy ('polypill') on cardiovascular risk factors
    F Malekzadeh
    Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Int J Clin Pract 64:1220-7. 2010
    ..Our objective was to investigate the effects and tolerability of fixed-dose combination therapy on blood pressure and LDL in adults without elevated blood pressure or lipid levels...
  17. ncbi Aliskiren reduces blood pressure and suppresses plasma renin activity in combination with a thiazide diuretic, an angiotensin-converting enzyme inhibitor, or an angiotensin receptor blocker
    Eoin O'Brien
    Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Hypertension 49:276-84. 2007
    ..measurement, aliskiren was administered to patients with mild-to-moderate hypertension in combination with hydrochlorothiazide (n=23), ramipril (n=21), or irbesartan (n=23)...
  18. ncbi The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial
    Hans Lithell
    Department of Public Health and Caring Sciences, Sections of Geriatrics Clinical Hypertension Research and Family Medicine, University of Uppsala, Uppsala, Sweden
    J Hypertens 21:875-86. 2003
    ..The prognostic benefits of blood pressure lowering treatment in elderly hypertensive patients were established more than a decade ago, but are less clear in those with mildly to moderately elevated blood pressure...
  19. ncbi Irbesartan/hydrochlorothiazide for the treatment of isolated systolic hypertension: a subgroup analysis of the INCLUSIVE trial
    Steven G Chrysant
    Oklahoma Cardiovascular and Hypertension Center and the University of Oklahoma School of Medicine, 5850 W Wilshire Blvd, Oklahoma City, OK 73132, USA
    J Natl Med Assoc 101:300-7. 2009
    This post hoc analysis of the Irbesartan/Hydrochlorothiazide (HCTZ) Blood Pressure Reductions in Diverse Patient Populations (INCLUSIVE) trial evaluated the efficacy and safety of fixed-dose irbesartan/HCTZ in patients with isolated ..
  20. ncbi Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction
    A Monroy
    Molecular Physiology Unit, Instituto Nacional de la Nutrición Salvador Zubirán and Instituto de Investigaciones Biomédicas, National University of Mexico, Tlalpan 14000 Mexico City, Mexico
    Am J Physiol Renal Physiol 279:F161-9. 2000
    ..Both ion binding sites alter thiazide-mediated inhibition of transport, indicating that the thiazide-binding site is either shared or modified by both Na(+) and Cl(-)...
  21. ncbi Azilsartan medoxomil plus chlorthalidone reduces blood pressure more effectively than olmesartan plus hydrochlorothiazide in stage 2 systolic hypertension
    William C Cushman
    University of Tennessee College of Medicine, Memphis, TN, USA
    Hypertension 60:310-8. 2012
    ..combination of the angiotensin II receptor blocker olmesartan medoxomil plus the thiazide diuretic hydrochlorothiazide force titrated to 40/25 mg...
  22. ncbi Telmisartan/Hydrochlorothiazide: a review of its use as fixed-dose combinations in essential hypertension
    Greg L Plosker
    Wolters Kluwer Health Adis, Auckland, New Zealand
    Drugs 68:1877-99. 2008
    Fixed-dose combinations of telmisartan and hydrochlorothiazide (HCTZ) [Micardis Plus, Micardis HCT, PritorPlus] are available in many countries for the treatment of patients with essential hypertension...
  23. ncbi Safety and benefits of a tablet combining losartan and hydrochlorothiazide in Japanese diabetic patients with hypertension
    Kenichiro Kinouchi
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 32:1143-7. 2009
    This study was conducted to determine the effects of a tablet combining losartan/hydrochlorothiazide (L/HCTZ) in comparison with losartan alone in Japanese diabetic patients with hypertension...
  24. ncbi Triple therapy with olmesartan medoxomil, amlodipine besylate, and hydrochlorothiazide in adult patients with hypertension: The TRINITY multicenter, randomized, double-blind, 12-week, parallel-group study
    Suzanne Oparil
    University of Alabama at Birmingham, 35294 0007, USA
    Clin Ther 32:1252-69. 2010
    ..Patients with hypertension may require a combination of > or =2 antihypertensive agents to achieve blood pressure (BP) control...
  25. ncbi Predictors of antihypertensive response to a standard dose of hydrochlorothiazide for essential hypertension
    Arlene B Chapman
    Renal Division, Department of Medicine, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Kidney Int 61:1047-55. 2002
    ..system (RAAS) have been associated with variation in blood pressure response to hydrochlorothiazide, whether these characteristics make additive contributions to predicting response has not been established...
  26. ncbi Differential effects of strict blood pressure lowering by losartan/hydrochlorothiazide combination therapy and high-dose amlodipine monotherapy on microalbuminuria: the ALPHABET study
    Motoki Fukutomi
    Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan
    J Am Soc Hypertens 6:73-82. 2012
    We investigated the effects of losartan/hydrochlorothiazide (HCTZ) fixed combination therapy and high-dose amlodipine monotherapy on BP measurements and target organ protection...
  27. ncbi Chemometric resolution of a mixture containing hydrochlorothiazide and amiloride by absorption and derivative spectrophotometry
    Erdal Dinc
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Ankara, 06100 Tandogan, Ankara, Turkey
    J Pharm Biomed Anal 29:371-9. 2002
    ..PLSR) were applied to the absorption and derivative spectrophotometric determinations of amiloride and hydrochlorothiazide in a pharmaceutical preparation...
  28. ncbi Pharmaceutical composition of hydrochlorothiazide:β-cyclo-dextrin: preparation by three different methods, physico-chemical characterization and in vivo diuretic activity evaluation
    Maria Arlete Silva Pires
    Departamento de Quimica, ICEx, Universidade Federal de Minas Gerais, Avenida Pres Antônio Carlos 6627, 31270 901 Belo Horizonte, Brazil
    Molecules 16:4482-99. 2011
    b>Hydrochlorothiazide is a common diuretic antihypertensive drug of the thiazide family. Its poor aqueous solubility is one of the reasons for its limited bioavailability after oral administration...
  29. ncbi One-year effectiveness and safety of open-label losartan/hydrochlorothiazide combination therapy in Japanese patients with hypertension uncontrolled with ARBs or ACE inhibitors
    Toshihiro Kita
    Faculty of Medicine, Department of Internal Medicine, Division of Circulatory and Body Fluid Regulation, University of Miyazaki, Miyazaki, Japan
    Hypertens Res 33:320-5. 2010
    The long-term antihypertensive efficacy and safety of losartan/hydrochlorothiazide (HCTZ) combinations have not been appropriately evaluated in Japan...
  30. ncbi Half a century of hydrochlorothiazide: facts, fads, fiction, and follies
    Franz H Messerli
    Division of Cardiology, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Med 124:896-9. 2011
    b>Hydrochlorothiazide (HCTZ) has become by far the most commonly prescribed antihypertensive drug in the US. In 2008, 47.8 million prescriptions were written for HCTZ alone and 87.1 million prescriptions for HCTZ combinations...
  31. ncbi Effectiveness of nebivolol and hydrochlorothiazide association on blood pressure, glucose, and lipid metabolism in hypertensive patients
    Giuseppe Marazzi
    IRCCS San Raffaele Pisana, Via della Pisana, 235 00163 Roma, Italy
    Adv Ther 27:655-64. 2010
    ..The aim of the study was to evaluate the efficacy of nebivolol alone and in association with hydrochlorothiazide (HCT) in reducing BP in hypertensive patients with new-onset, mild-to-moderate hypertension, and to assess ..
  32. pmc Adding thiazide to a renin-angiotensin blocker improves left ventricular relaxation and improves heart failure in patients with hypertension
    Hiroshi Ito
    Department of Cardiovascular Medicine, Okayama University, Graduate School of Medicine, Okayama, Japan
    Hypertens Res 35:93-9. 2012
    ..In this study, we investigated the effect of changing an ACEi or ARB to a combination of losartan and hydrochlorothiazide (HCTZ) on left ventricular (LV) preload and relaxation in patients with hypertension and diastolic ..
  33. ncbi Rationale and design of the Newer Versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) trial
    Augustine N Odili
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Blood Press 20:256-66. 2011
    ....
  34. pmc 24-Hour ambulatory blood pressure control with triple-therapy amlodipine, valsartan and hydrochlorothiazide in patients with moderate to severe hypertension
    Y Lacourciere
    Hypertension Research Unit, Centre Hospitalier Universitaire de Quebec, Quebec, Canada
    J Hum Hypertens 25:615-22. 2011
    To determine the effectiveness and safety of once-daily combination therapy with amlodipine, valsartan and hydrochlorothiazide for reducing ambulatory blood pressure (ABP) in patients with moderate to severe hypertension, a multicenter, ..
  35. ncbi Effects of high dose olmesartan medoxomil plus hydrochlorothiazide on blood pressure control in patients with grade 2 and grade 3 hypertension
    L C Rump
    Department of Internal Medicine Nephrology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    J Hum Hypertens 25:565-74. 2011
    ..Adding hydrochlorothiazide (HCTZ) to OM increases efficacy, but has not been evaluated in patients inadequately controlled by OM 40 mg...
  36. ncbi Blood pressure-lowering and antiproteinuric effect of switching from high-dose angiotensin receptor blockers to normal-dose telmisartan and low-dose hydrochlorothiazide in hypertensive patients with chronic kidney disease
    M Abe
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Itabashi ku, Tokyo, Japan
    Int J Clin Pharmacol Ther 48:206-13. 2010
    ..patients with mild to moderate chronic kidney disease (CKD) after switching from the high-dose angiotensin receptor blockers (ARBs) to a combination of normal-dose telmisartan (40 mg) and low-dose hydrochlorothiazide (HCTZ; 12.5 mg).
  37. pmc Comparison of office, ambulatory, and home blood pressure antihypertensive response to atenolol and hydrochlorthiazide
    Amber L Beitelshees
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    J Clin Hypertens (Greenwich) 12:14-21. 2010
    ..sought to compare office BP (OBP), home BP (HBP), and ambulatory BP (ABP) for measuring responses to hydrochlorothiazide (HCTZ), atenolol, and their combination...
  38. ncbi Efficacy and duration of benazepril plus amlodipine or hydrochlorothiazide on 24-hour ambulatory systolic blood pressure control
    Kenneth A Jamerson
    Division of Cardiovascular Medicine, Ann Arbor, MI 48106, USA
    Hypertension 57:174-9. 2011
    The combination of benazepril plus amlodipine was shown to be more effective than benazepril plus hydrochlorothiazide in reducing cardiovascular events in the Avoiding Cardiovascular Events through Combination Therapy in Patients Living ..
  39. ncbi A thiazide test for the diagnosis of renal tubular hypokalemic disorders
    Giacomo Colussi
    Unité Operative Nefrologia, Ospedale di Circolo e Fondazione Macchi, Varese, Italy
    Clin J Am Soc Nephrol 2:454-60. 2007
    ..with genetically proven GS or BS diagnostic sensibility and specificity of a diuretic test with oral hydrochlorothiazide (HCT test)...
  40. ncbi Hydrochlorothiazide versus chlorthalidone in the management of hypertension
    Kimberly M Neff
    New Mexico VA Health Care System, Albuquerque, NM, USA
    Cardiol Rev 18:51-6. 2010
    ..Although there are several thiazide diuretics currently available, hydrochlorothiazide (HCTZ) continues to be the most popular thiazide used for treating high blood pressure...
  41. pmc Irbesartan/HCTZ fixed combinations in patients of different racial/ethnic groups with uncontrolled systolic blood pressure on monotherapy
    Elizabeth O Ofili
    Clinical Research Center, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Natl Med Assoc 98:618-26. 2006
    The IrbesartaN/hydroChlorothiazide (HCTZ) bLood pressUre reductionS In diVErse patient populations (INCLUSIVE) trial was a multicenter, prospective, open-label, single-arm study evaluating the efficacy and safety of irbesartan/HCTZ fixed ..
  42. ncbi Reasons for not intensifying antihypertensive treatment (RIAT): a primary care antihypertensive intervention study
    Paolo Ferrari
    Department of Nephrology, Fremantle Hospital, Perth, Australia
    J Hypertens 22:1221-9. 2004
    ....
  43. ncbi Thiazide diuretics exacerbate fructose-induced metabolic syndrome
    Sirirat Reungjui
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida, USA
    J Am Soc Nephrol 18:2724-31. 2007
    ..Addition of potassium supplements and allopurinol with thiazides might be helpful in the management of metabolic syndrome...
  44. ncbi Long-term safety, tolerability and efficacy of aliskiren in combination with valsartan in patients with hypertension: a 6-month interim analysis
    Steven G Chrysant
    University of Oklahoma, Oklahoma City, OK 73132, USA
    Curr Med Res Opin 24:1039-47. 2008
    ..Here we report the results of a pre-planned 6-month interim analysis of a long-term, open-label study examining the safety, tolerability and efficacy of the aliskiren/valsartan 300/320-mg combination in patients with hypertension...
  45. ncbi Impact of angiotensin receptor blockade in combination with hydrochlorothiazide 25 mg in 2121 patients with stage 1-2 hypertension
    W B White
    Division of Hypertension and Clinical Pharmacology, Pat and Jim Calhoun Cardiology Center, University of Connecticut School of Medicine, Farmington, CT 06030, USA
    J Hum Hypertens 23:817-25. 2009
    The antihypertensive effects of telmisartan 80 mg versus valsartan 160 mg, both combined with hydrochlorothiazide (HCTZ) 25 mg, were assessed in a pooled analysis from two large trials with identical study designs in patients with stage ..
  46. pmc Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan
    Liffert Vogt
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
    J Am Soc Nephrol 19:999-1007. 2008
    ..placebo-controlled trial to determine the separate and combined effects of a low-sodium diet and hydrochlorothiazide (HCT) on proteinuria and BP was performed...
  47. ncbi A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial
    Carl J Pepine
    Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville 32610, USA
    JAMA 290:2805-16. 2003
    ..Despite evidence of efficacy of antihypertensive agents in treating hypertensive patients, safety and efficacy of antihypertensive agents for coronary artery disease (CAD) have been discerned only from subgroup analyses in large trials...
  48. pmc The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension
    Ewout J Hoorn
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, Oregon, USA
    Nat Med 17:1304-9. 2011
    ..Moreover, hydrochlorothiazide, an NCC-blocking drug, reversed tacrolimus-induced hypertension...
  49. ncbi Chlorthalidone reduces cardiovascular events compared with hydrochlorothiazide: a retrospective cohort analysis
    Michael P Dorsch
    University of Michigan Health System, B2D301 SPC 5008, 1500 East Medical Center Dr, Ann Arbor, MI 48109 5008, USA
    Hypertension 57:689-94. 2011
    There is significant controversy around whether chlorthalidone (CTD) is superior to hydrochlorothiazide (HCTZ) in hypertension management...
  50. ncbi Analysis of binary mixtures of losartan potassium and hydrochlorothiazide by using high performance liquid chromatography, ratio derivative spectrophotometric and compensation technique
    N Erk
    Faculty of Pharmacy, Department of Analytical Chemistry, University of Ankara, Turkey
    J Pharm Biomed Anal 24:603-11. 2001
    ..two spectrophotometric methods have been described for resolving binary mixture of losartan potassium and hydrochlorothiazide in the pharmaceutical formulations...
  51. ncbi WNK1 kinase polymorphism and blood pressure response to a thiazide diuretic
    Stephen T Turner
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN, USA
    Hypertension 46:758-65. 2005
    ..9 years of age; 50% blacks; 47% women) were treated with hydrochlorothiazide for 4 weeks (25 mg daily, orally) to determine office BP responses...
  52. ncbi Blood pressure-lowering efficacy of amiloride versus enalapril as add-on drugs in patients with uncontrolled blood pressure receiving hydrochlorothiazide
    Patrícia Guerrero
    Graduate Study Program in Health Sciences Cardiology, Universidade Federal do Rio Grande do Sul UFRGS, Brazil
    Clin Exp Hypertens 30:553-64. 2008
    ..In a double-blind randomized clinical trial, 82 patients with uncontrolled BP, receiving hydrochlorothiazide 25 mg daily, were selected to receive amiloride 2.5-5 mg/day (n = 39) or enalapril 10-20 mg/day (n = 43)...
  53. ncbi [Effect of candesartan cilexetil with hydrochlorothiazide on blood pressure and ST-segment depression in patients with arterial hypertension]
    S Uen
    Abteilung für Hypertonie und Angiologie, Medizinische Universitäts Poliklinik der Universität Bonn
    Dtsch Med Wochenschr 132:81-6. 2007
    To examine the effect of candesartan cilexetil with hydrochlorothiazide (6 mg and 12...
  54. ncbi Multidrug resistance-associated protein 4 is involved in the urinary excretion of hydrochlorothiazide and furosemide
    Maki Hasegawa
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
    J Am Soc Nephrol 18:37-45. 2007
    ..Significant ATP-dependent uptake of hydrochlorothiazide (HCT) and furosemide was observed in membrane vesicles that expressed multidrug resistance-associated ..
  55. ncbi Effects of losartan versus hydrochlorothiazide on indices of endothelial damage/dysfunction, angiogenesis and tissue factor in essential hypertension
    Natali Ay Chung
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Blood Press 13:183-9. 2004
    ..We hypothesized that the treatment of essential hypertension with the angiotensin II receptor antagonist, losartan, would affect endothelial damage/dysfunction, angiogenesis and coagulation, when compared to treatment with a diuretic...
  56. ncbi Safety and tolerability of fixed-dose irbesartan/hydrochlorothiazide for rapid control of severe hypertension
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    Clin Exp Hypertens 31:572-84. 2009
    This prospective, double-blind, multicenter trial compared the safety and tolerability of irbesartan/hydrochlorothiazide (HCTZ) fixed-dose combination therapy with irbesartan monotherapy in patients with severe hypertension (seated ..
  57. ncbi Irbesartan/Hydrochlorothiazide : in moderate to severe hypertension
    Jamie D Croxtall
    Wolters Kluwer Health Adis, Auckland, New Zealand
    Drugs 68:1465-72. 2008
    The fixed-dose combination of irbesartan/hydrochlorothiazide (HCTZ) is approved in the US for use as initial therapy in patients who are likely to need multiple agents to achieve their blood pressure (BP) goals...
  58. pmc Clinical efficacy and safety of olmesartan/hydrochlorothiazide combination therapy in patients with essential hypertension
    Luis M Ruilope
    Unidad de Hipertension, Hospital 12 de Octubre, Madrid, Spain
    Vasc Health Risk Manag 4:1237-48. 2008
    ..Combining an angiotensin II receptor blocker (ARB) with hydrochlorothiazide (HCTZ) has been shown in clinical studies to increase the antihypertensive efficacy of both agents compared ..
  59. ncbi Fixed-dose manidipine/delapril versus losartan/hydrochlorothiazide in hypertensive patients with type 2 diabetes and microalbuminuria
    Osvaldo Kohlmann
    Kidney and Hypertension Hospital, Federal University of Sao Paulo, Rua Leandro Dupret 365, Sao Paulo, 04025 011, Brazil
    Adv Ther 26:313-24. 2009
    ..The present study aimed to examine the effects of a fixed-dose combination of antihypertensives on blood pressure and microalbuminuria...
  60. ncbi Cost-effectiveness of irbesartan/hydrochlorothiazide in patients with hypertension: an economic evaluation for Sweden
    M Ekman
    1i3 Innovus, Stockholm, Sweden
    J Hum Hypertens 22:845-55. 2008
    ..The purpose of this study was to assess the cost-effectiveness of irbesartan in combination with hydrochlorothiazide (HCTZ) in Swedish health-care setting by predicting clinical events and life years based upon observed ..
  61. pmc Office and ambulatory blood pressure control with a fixed-dose combination of candesartan and hydrochlorothiazide in previously uncontrolled hypertensive patients: results of CHILI CU Soon
    Thomas Mengden
    Kerckhoff Klinik GmbH, Bad Nauheim, Germany
    Vasc Health Risk Manag 7:761-9. 2011
    Fixed-dose combinations of candesartan 32 mg and hydrochlorothiazide (HCTZ) have been shown to be effective in clinical trials...
  62. ncbi Comparison of a fixed-dose combination of 40 mg telmisartan plus 12.5 mg hydrochlorothiazide with 40 mg telmisartan in the control of mild to moderate hypertension
    Yves Lacourciere
    Hypertension Research Unit, Center Hospitalier Universitaire de Québec, Quebec
    Am J Ther 9:111-7. 2002
    ..5 mg of the diuretic hydrochlorothiazide (HCTZ) was superior to 40 mg telmisartan in patients with mild to moderate hypertension who failed to ..
  63. ncbi The effects of telmisartan alone or with hydrochlorothiazide on morning and 24-h ambulatory BP control: results from a practice-based study (SURGE 2)
    Gianfranco Parati
    Department of Health Sciences, University of Milano Bicocca, Milan, Italy
    Hypertens Res 36:322-7. 2013
    ..practice-based study evaluated the effects of telmisartan 40 or 80 mg alone or in combination with hydrochlorothiazide (HCTZ) 12...
  64. pmc Moderate versus intensive treatment of hypertension using amlodipine/valsartan and with the addition of hydrochlorothiazide for patients uncontrolled on angiotensin receptor blocker monotherapy: results in racial/ethnic subgroups
    Elizabeth O Ofili
    Morehouse School of Medicine, Atlanta, Georgia, USA
    J Am Soc Hypertens 5:249-58. 2011
    ..b>Hydrochlorothiazide (HCTZ) 12...
  65. ncbi Efficacy, safety, and tolerability of valsartan/hydrochlorothiazide in Asian patients with essential hypertension
    Wen Ter Lai
    Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Adv Ther 28:427-38. 2011
    ..We performed the first multinational observational study of valsartan/hydrochlorothiazide (HCTZ) single pill combination in Asia to determine the efficacy, safety, and tolerability in hypertensive ..
  66. ncbi Hypertension associated polymorphisms in WNK1/WNK4 are not associated with hydrochlorothiazide response
    Yunfeng Han
    Department of Geriatrics, the Military General Hospital of Beijing PLA, Beijing, China
    Clin Biochem 44:1045-9. 2011
    ..Our purpose was to investigate whether with-no-K[Lys] kinase (WNK) 1 and WNK4 genetic polymorphisms are associated with both hypertension and diuretics response...
  67. ncbi Treating systolic hypertension in the very elderly with valsartan-hydrochlorothiazide vs. either monotherapy: ValVET primary results
    Joseph L Izzo
    State University of New York at Buffalo, Buffalo, NY, USA
    J Clin Hypertens (Greenwich) 13:722-30. 2011
    This 16-week trial investigated the efficacy and safety of single-pill valsartan/hydrochlorothiazide (HCTZ) vs. the individual components in patients 70 years and older with systolic hypertension...
  68. ncbi Effects of nebivolol or irbesartan in combination with hydrochlorothiazide on vascular functions in newly-diagnosed hypertensive patients: the NINFE (Nebivololo, Irbesartan Nella Funzione Endoteliale) study
    Cristiana Vitale
    Department of Medical Sciences, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Pisana, Rome, Italy
    Int J Cardiol 155:279-84. 2012
    ..study was to test the hypothesis of non-inferiority of nebivolol to irbesartan, both in association with hydrochlorothiazide, on endothelial function, arterial stiffness and central hemodynamic parameters in patients with arterial ..
  69. pmc Blood pressure responses and metabolic effects of hydrochlorothiazide and atenolol
    Steven M Smith
    Department of Clinical Pharmacy, University of Colorado School of Pharmacy, Aurora, Colorado, USA
    Am J Hypertens 25:359-65. 2012
    ..We aimed to determine whether AMEs are correlated with BP response in uncomplicated hypertensives...
  70. ncbi Efficacy and safety of a single-pill fixed-dose combination of high-dose telmisartan/hydrochlorothiazide in patients with uncontrolled hypertension
    Yuhei Shiga
    Department of Cardiology, Fukuoka University School of Medicine, Japan
    J Renin Angiotensin Aldosterone Syst 13:394-400. 2012
    ..angiotensin II type 1 receptor blockers (ARBs) or Preminent® (medium-dose of losartan (50 mg/day)/hydrochlorothiazide (HCTZ) (12.5 mg/day))...
  71. ncbi [Effects of valsartan combined with amlodipine or hydrochlorothiazide regimen on blood pressure variation in elderly hypertensive patients]
    Ze bing Wu
    Department of Geriatrics, Anhui Medical University, Hefei, China
    Zhonghua Xin Xue Guan Bing Za Zhi 40:8-13. 2012
    To compare the effects of valsartan combined with amlodipine or hydrochlorothiazide regimen on blood pressure variation and plasma nitric oxide (NO) and endothelin (ET) in elderly hypertensive patients.
  72. ncbi Efficacy of olmesartan medoxomil and hydrochlorothiazide fixed-dose combination therapy in patients aged 65 years and older with stage 1 and 2 hypertension or isolated systolic hypertension
    F Wilford Germino
    Department of Internal Medicine, Orland Primary Care Specialists, Orland Park, IL 60467, USA
    Am J Cardiovasc Drugs 12:325-33. 2012
    ..A combination antihypertensive therapy regimen may be required to reach recommended BP goals in older patients...
  73. ncbi Development and validation of a liquid chromatographic/electrospray ionization mass spectrometric method for the determination of benazepril, benazeprilat and hydrochlorothiazide in human plasma
    Ariadni Vonaparti
    University of Athens, School of Pharmacy, Division of Pharmaceutical Chemistry, Panepistimiopolis, Zografou 157 71, Athens, Greece
    J Mass Spectrom 41:593-605. 2006
    A new method was developed and fully validated for the quantitation of benazepril, benazeprilat and hydrochlorothiazide in human plasma. Sample pretreatment was achieved by solid-phase extraction (SPE) using Oasis HLB cartridges...
  74. ncbi Triple combination therapy to improve blood pressure control: experience with olmesartan-amlodipine-hydrochlorothiazide therapy
    Giuliano Tocci
    IRCCS Neuromed, Pozzilli, Italy
    Expert Opin Pharmacother 13:2687-97. 2012
    ....
  75. ncbi Comparative efficacy of irbesartan/ hydrochlorothiazide and valsartan/hydrochlorothiazide combination in lowering blood pressure: a retrospective observational study in Oman
    K A Al Balushi
    Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, Oman
    Med Princ Pract 22:265-9. 2013
    To compare blood pressure (BP) control in patients receiving irbesartan/hydrochlorothiazide (HCTZ) and valsartan/HCTZ at a tertiary care university hospital in Oman.
  76. ncbi Physicochemical properties of liposomes incorporating hydrochlorothiazide and chlorothiazide
    D G Fatouros
    Laboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, University of Patras, Rio 26500, Patras, Greece
    J Drug Target 9:61-74. 2001
    ..liposomes (MLV) consisting of phosphatidylcholine (PC) and incorporating chlorothiazide (CT) or hydrochlorothiazide (HCT), were prepared and characterized...
  77. ncbi Cardiac cellular actions of hydrochlorothiazide
    L Galan
    Laboratorio de Electrofisiologia, Instituto de Cardiologia y Cirugia Cardiovascular, La Habana, Cuba Laboratorio de Fisiología Cardiovascular, Instituto de Fisiologia, Universidad Autonoma de Puebla, Puebla, Mexico
    Fundam Clin Pharmacol 15:9-17. 2001
    In long term treatment, thiazide diuretics such as hydrochlorothiazide (HCTZ) lower blood pressure by decreasing peripheral resistance rather than by their diuretic effect...
  78. ncbi In vivo evaluation of hydrochlorothiazide liquisolid tablets in beagle dogs
    K A Khaled
    Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, 11451, Riyadh, Saudi Arabia
    Int J Pharm 222:1-6. 2001
    This study was carried out to evaluate the absorption characteristics of experimentally developed hydrochlorothiazide liquisolid tablets using six male beagle dogs. Comparison with reference commercial tablets was made...
  79. ncbi Titration of HCTZ to 50 mg daily in individuals with stage 2 systolic hypertension pretreated with an angiotensin receptor blocker
    Joseph L Izzo
    Department of Medicine, State University of New York at Buffalo, Buffalo, NY 14215, USA
    J Clin Hypertens (Greenwich) 9:45-8. 2007
    The authors studied the combination of hydrochlorothiazide (HCTZ) 50 mg/d plus olmesartan medoxomil (OM) 40 mg/d in stage 2 systolic hypertension during an extension phase of an open-label 12-week dose titration study...
  80. ncbi Effects of long-term lercanidipine or hydrochlorothiazide administration on hypertension-related vascular structural changes
    Guido Grassi
    Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita Milano Bicocca, Ospedale San Gerardo, Monza, Milan, Italy
    Blood Press 15:268-74. 2006
    ..of the highly vasoselective calcium-channel blocker lercanidipine (10 mg/day) or the diuretic compound hydrochlorothiazide (25 mg/day) on hypertension-related vascular alterations...
  81. ncbi Losartan-hydrochlorothiazide association promotes lasting blood pressure normalization and completely arrests long-term renal injury in the 5/6 ablation model
    Clarice Kazue Fujihara
    Renal Division, Department of Clinical Medicine, Faculty of Medical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Am J Physiol Renal Physiol 292:F1810-8. 2007
    ..We investigated the effect of hydrochlorothiazide (H), alone or combined with losartan (L), in the 5/6 renal ablation model (Nx)...
  82. ncbi Antihypertensive efficacy and tolerability of irbesartan/hydrochlorothiazide in hypertensive patients stratified by body mass index and type 2 diabetes mellitus status: a post hoc subgroup analysis of the Irbesartan/HCTZ Blood Pressure Reductions in Diver
    Andrew J Lewin
    National Research Institute, 2010 Wilshire Boulevard, Suite 302, Los Angeles, CA 90057, USA
    Clin Ther 30:2354-65. 2008
    ..The BMI subgroup data were also analyzed according to the presence or absence of type 2 diabetes mellitus (T2DM) at baseline...
  83. ncbi Chlorthalidone compared with hydrochlorothiazide in reducing cardiovascular events: systematic review and network meta-analyses
    George C Roush
    Department of Medicine, St Vincent s Medical Center, 2800 Main St, Bridgeport, CT 06606, USA
    Hypertension 59:1110-7. 2012
    b>Hydrochlorothiazide (HCTZ) is widely used for hypertension, and prescriptions for HCTZ outnumber those for chlorthalidone (CTDN) by >20-fold in 2 recent surveys. Some have recently expressed a preference for CTDN...
  84. ncbi Efficacy and safety of triple-combination therapy with olmesartan, amlodipine, and hydrochlorothiazide in study participants with hypertension and diabetes: a subpopulation analysis of the TRINITY study
    Steven G Chrysant
    Oklahoma Cardiovascular and Hypertension Center and University of Oklahoma College of Medicine, Oklahoma City, OK, USA
    J Am Soc Hypertens 6:132-41. 2012
    ..This prespecified subgroup analysis from the TRIple Therapy with Olmesartan Medoxomil, Amlodipine, and Hydrochlorothiazide in HyperteNsIve PatienTs StudY assessed the efficacy and safety of triple-combination treatment (olmesartan ..
  85. ncbi Use of the factorial design and quadratic response surface models to evaluate the fosinopril and hydrochlorothiazide combination therapy in hypertension
    J L Pool
    Section on Hypertension and Clinical Pharmacology, Baylor College of Medicine, Houston, Texas, USA
    Am J Hypertens 10:117-23. 1997
    ..study the efficacy of 17 different doses of fosinopril (Fos), a phosphinic acid derived ACE inhibitor, and hydrochlorothiazide (HCTZ) in 550 patients with mild to moderate hypertension...
  86. ncbi Efficacy of amlodipine/olmesartan ± hydrochlorothiazide in patients uncontrolled on prior calcium channel blocker or angiotensin II receptor blocker monotherapy
    Joel Neutel
    Department of Clinical Pharmacology, Orange County Research Center, Tustin, CA 92780, USA
    Adv Ther 29:508-23. 2012
    ..and safety of initiating patients on a regimen of fixed-dose amlodipine (AML)/olmesartan medoxomil (OM) ± hydrochlorothiazide (HCTZ) who were uncontrolled on prior monotherapy with a calcium channel blocker (CCB) or angiotensin II ..
  87. ncbi Efficacy and safety of triple antihypertensive therapy with the olmesartan/amlodipine/hydrochlorothiazide combination
    Massimo Volpe
    Division of Cardiology, Department of Clinical and Molecular Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    Clin Drug Investig 32:649-64. 2012
    ....
  88. ncbi A randomized trial of furosemide vs hydrochlorothiazide in patients with chronic renal failure and hypertension
    Bertrand Dussol
    Service de Néphrologie Hémodialyse Transplantation, Hopital de la Conception, 147 Bd Baille, 13385 Marseille Cedex 5, France
    Nephrol Dial Transplant 20:349-53. 2005
    ..However, the adaptive changes in the distal nephron and the short half-life of these drugs may decrease their long-term efficacy. Thiazides are not believed to be efficient in advanced renal failure, but this is debated...
  89. pmc Lack of association between polymorphisms in STK39, a putative thiazide response gene, and blood pressure response to hydrochlorothiazide
    Julio D Duarte
    Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida College of Pharmacy, Gainesville, Florida 32610, USA
    Pharmacogenet Genomics 20:516-9. 2010
    ..One hundred and ninety-five 'good' and 194 'poor' responders to hydrochlorothiazide (HCTZ) were genotyped for approximately 100 single nucleotide polymorphisms (SNPs) within 5000 bases of ..
  90. ncbi Effects of valsartan/hydrochlorothiazide and amlodipine on ambulatory blood pressure and plasma norepinephrine levels in high-risk hypertensive patients
    Ettore Malacco
    L Sacco Hospital, University of Milan, Milan, Italy
    Adv Ther 21:149-61. 2004
    The efficacy and tolerability of the combination of valsartan and hydrochlorothiazide (HCTZ) were compared with that of amlodipine in reducing ambulatory blood pressure and plasma norepinephrine levels in patients with mild to moderate ..
  91. ncbi Racial differences in response to acute dosing with hydrochlorothiazide
    E Ripley
    Division of Nephrology, Medical College of Virginia Commonwealth University, Richmond, USA
    Am J Hypertens 13:157-64. 2000
    ..This study examined the pharmacokinetic (PK), pharmacodynamic, and neurohumoral effects of hydrochlorothiazide (HCTZ) administration in a matched group of 9 black and 9 white hypertensive patients (mean +/- SD for ..
  92. ncbi Safety and tolerability of eprosartan in combination with hydrochlorothiazide
    Michael Bohm
    Medical University and Poliklinik, Homburg, Germany
    Drug Saf 25:599-611. 2002
    ..Indeed, the combination of eprosartan and the thiazide diuretic hydrochlorothiazide has been shown to be effective in further reducing blood pressure in patients not optimally responding to ..
  93. pmc Acute-onset bilateral myopia and ciliochoroidal effusion induced by hydrochlorothiazide
    Young Rae Roh
    Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
    Korean J Ophthalmol 25:214-7. 2011
    The authors experienced two cases of hydrochlorothiazide (HCTZ)-induced acute-onset bilateral myopia and shallowing of the anterior chambers...
  94. ncbi Comparison of the efficacy and safety of single-pill fixed-dose combinations of losartan/hydrochlorothiazide and valsartan/hydrochlorothiazide in patients with hypertension (SALT-VAT study)
    Yuhei Shiga
    Department of Cardiology, Fukuoka University School of Medicine, Japan
    Intern Med 50:2477-83. 2011
    ..We analyzed the efficacy and safety of Preminent(®) [losartan (50 mg/day)/HCTZ (12.5 mg/day)] compared to CodioMD(®) [valsartan (80 mg/day)/HCTZ (6.25 mg/day)]...
  95. ncbi A comparison of the efficacy and safety of irbesartan/hydrochlorothiazide combination therapy with irbesartan monotherapy in the treatment of moderate or severe hypertension in diabetic and obese hypertensive patients: a post-hoc analysis review
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    Postgrad Med 123:126-34. 2011
    ..or untreated moderate or severe hypertension, the efficacy and safety of treatment with irbesartan/hydrochlorothiazide (HCTZ) and irbesartan was assessed in 2 separate analyses: patients with diabetes (n=143) and by obesity ..
  96. ncbi Effectiveness of add-on low-dose diuretics in combination therapy for hypertension: losartan/hydrochlorothiazide vs. candesartan/amlodipine
    Tatsuo Shimosawa
    Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Hypertens Res 30:831-7. 2007
    ..In this randomized 4-month study, the efficacy and safety were compared between an ARB/diuretics (losartan/hydrochlorothiazide [HCTZ]) combination and the most prescribed combination, ARB/calcium channel blocker (candesartan/..
  97. ncbi Simultaneous spectrophotometric determination of valsartan and hydrochlorothiazide by H-point standard addition method and partial least squares regression
    Karunanidhi Santhana Lakshmi
    Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM University, Kattankulathur 603 203, India
    Acta Pharm 61:37-50. 2011
    Simultaneous determination of valsartan and hydrochlorothiazide by the H-point standard additions method (HPSAM) and partial least squares (PLS) calibration is described...
  98. ncbi Aliskiren alone or in combination with hydrochlorothiazide in patients with the lower ranges of stage 2 hypertension: The ACQUIRE randomized double-blind study
    Henry R Black
    New York University School of Medicine, New York, NY, USA
    J Clin Hypertens (Greenwich) 12:917-26. 2010
    ..After a 2- to 4-week washout period, 688 patients were randomized to once-daily aliskiren/hydrochlorothiazide (HCT) 150/12.5mg or aliskiren 150mg for 1 week and then double the doses for 11 weeks. Baseline BP was 167...
  99. ncbi Variability in response to antihypertensive drugs
    Barry J Materson
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    Am J Med 120:S10-20. 2007
    ..It is also helpful when designing treatment protocols for individual patients with hypertension and in assessing their response to therapy...
  100. pmc Olmesartan/amlodipine/hydrochlorothiazide in participants with hypertension and diabetes, chronic kidney disease, or chronic cardiovascular disease: a subanalysis of the multicenter, randomized, double-blind, parallel-group TRINITY study
    Dean J Kereiakes
    The Christ Hospital Heart and Vascular Center at the Christ Hospital, Cincinnati, OH, USA
    Cardiovasc Diabetol 11:134. 2012
    ..Patients with hypertension and cardiovascular disease (CVD), diabetes, or chronic kidney disease (CKD) usually require two or more antihypertensive agents to achieve blood pressure (BP) goals...
  101. ncbi A multicenter, randomized double-blind study of valsartan/hydrochlorothiazide combination versus amlodipine in patients with mild to moderate hypertension
    P Palatini
    Dipartimento di Medicina Clinica e Sperimentale, Universita di Padova, Padova, Italy
    J Hypertens 19:1691-6. 2001
    To compare the antihypertensive efficacy and tolerability of a once-daily fixed valsartan/hydrochlorothiazide (HCTZ) combination and amlodipine in subjects with mild-to-moderate hypertension.

Research Grants57

  1. The Relationship Between STK39, Salt Sensitivity, and HCTZ-induced BP Response
    YEN PEI CHRISTY CHANG; Fiscal Year: 2010
    ..intravenous NaCl loading protocol followed by a dose-dependent pharmacologic BP lowering intervention with hydrochlorothiazide, a commonly prescribed thiazide diuretic...
  2. Transcriptional Regulation of Natriuetic Sensitivity in Diabetes Mellitus
    PATIENCE O OBIH; Fiscal Year: 2012
    ..that deletion of PPAR1 gene caused a defective Na-Cl cotransporter (NCC) activity as evidenced by a reduced hydrochlorothiazide-sensitive sodium excretion...
  3. Metabolomics Network for Drug Response Phenotype
    RIMA F KADDURAH DAOUK; Fiscal Year: 2010
    ..mechanisms of variation in response to commonly used cardiovascular drugs: antihypertensives (atenolol and hydrochlorothiazide ) and antiplatelet therapies (clopidogrel and aspirin)...
  4. Hypertension, angiotensin receptor blockers, cognition: effects and mechanisms
    Ihab M Hajjar; Fiscal Year: 2013
    ..test the feasibility, safety and effect size of candesartan, an angiotensin receptor blocker, compared to hydrochlorothiazide and lisinopril, in individuals with hypertension and mild cognitive impairment characterized by executive ..
  5. Aldosterone and Diabetic Cardiovascular Disease: Research and Mentoring Progam
    GAIL KURR ADLER; Fiscal Year: 2013
    ..with the MR antagonist eplerenone improves coronary circulatory function as compared to treatment with hydrochlorothiazide (HCTZ) in subjects with diabetes receiving angiotensin-converting enzyme (ACE) inhibition therapy...
  6. Multivariate Analysis of Candidate Blood Pressure Response Genes in Hypertensives
    Andrei Rodin; Fiscal Year: 2010
    ..apply "pathway", or "systems biology", data analysis methods to the association study of BP response to a hydrochlorothiazide in 585 hypertensive individuals...
  7. DIURETICS, HYPERTENSION, AND ARRHYTHMIAS CLINICAL TRIAL
    Stephen Hulley; Fiscal Year: 1990
    ..MRFIT) revealed an unexpected subgroup finding: an association between diuretic treatment (especially with hydrochlorothiazide) and an increased rate of sudden death in hypertensive men with resting ECG abnormalities...
  8. Genetics of Chronic Kidney Disease
    Stephen T Turner; Fiscal Year: 2010
    ..abstract_text> ..
  9. Genetics of Microangiopathic Brain Injury
    Stephen T Turner; Fiscal Year: 2010
    ..abstract_text> ..
  10. Anthipertensive PharmacoGenomics
    Stephen Turner; Fiscal Year: 2006
    ..abstract_text> ..
  11. GENETIC EPIDEMIOLOGY OF RESPONSES TO ANTIHYPERTENSIVES
    Stephen Turner; Fiscal Year: 2006
    ....
  12. AASK Cohort Study
    George Bakris; Fiscal Year: 2007
    ..Such results might eventually lead to new strategies that delay or prevent ESRD. ..
  13. ADVENTITIAL RESPONSE TO VASCULAR INJURY: ESTROGEN
    Suzanne Oparil; Fiscal Year: 2003
    ..These fundamental mechanistic studies will establish more rational strategies for therapeutic intervention in vascular diseases, including the basis for future gene therapy. ..
  14. Estrogen Modulates Injury-Induced Inflammation
    Suzanne Oparil; Fiscal Year: 2007
    ..These fundamental mechanistic studies will enhance our understanding of the pathobiology of vascular disease, particularly as it occurs in aging women, and will provide the basis for development of novel therapeutic strategies. ..
  15. Lipoproteins, HIV, and Antiretroviral Therapy in SMART
    Daniel Duprez; Fiscal Year: 2008
    ..This proposal will produce additional information that will enhance their disease-free survival rate. (End of Abstract) [unreadable] [unreadable] [unreadable]..
  16. ANG II AND IGF-1 INTERACTION IN CARDIOVASCULAR TISSUE
    James Sowers; Fiscal Year: 2003
    ..Thus, the proposed investigation will explore the role of PI3-kinase in mediating the cardiovascular interactions of AngII/IGF-1 after both short-term in vitro Ang II exposure and longer-term in vivo Ang II tissue excess. ..
  17. Angiotensin II Mediates Early Changes in Diabetic Kidney
    Helmy Siragy; Fiscal Year: 2007
    ..The proposed studies will help understand the mechanisms that are involved in diabetic the development of new therapeutic modalities to prevent or slowdown the development ..
  18. Beta-adrenoceptor genetic polymorphisms and obesity
    Julie Johnson; Fiscal Year: 2002
    ..Additionally, genotyping individuals early in age may help to identify those at increased risk of obesity prior to them becoming obese so that they may take appropriate preventive measures. ..
  19. Beta-receptors and cardiovascular pharmacogenomics
    Julie Johnson; Fiscal Year: 2006
    ..abstract_text> ..
  20. AASK Cohort Study
    Kenneth Jamerson; Fiscal Year: 2008
    ..Ultimately, data from the AASK Cohort Study should enhance our understanding of the determine the progression of kidney disease. Such results might eventually lead to new ESRD. ..
  21. BISPHOSPHONATE BONE QUALITY IN WOMEN WITH BREAST CANCER
    Susan Ott; Fiscal Year: 2009
    ..Results of the study will provide valuable information about skeletal effects of high-dose bisphosphonates in humans. ..
  22. Cardiovascular Effects of lyengar Yoga
    Raymond Townsend; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  23. BETA-ADRENERGIC RECEPTOR POLYMORPHISMS AND HYPERTENSION
    Julie Johnson; Fiscal Year: 2003
    ..the BAR genotype significantly impacts the BP response to B-blockers could lead to improved patient outcomes, as patients could be genotyped prior to institution of B-blocker therapy, thus avoiding this therapy in those likely to respond ..
  24. AT2 Receptor Modulates Renal Angiotensin II Levels
    Helmy Siragy; Fiscal Year: 2005
    ..Data obtained from this proposal will lead to increased understanding of the pathophysiology of hypertension and development of novel therapies for its management. ..
  25. DIETARY SALT INTAKE AND THE METABOLIC EFFECTS OF INSULIN
    Raymond Townsend; Fiscal Year: 2003
    ..If increased salt intake improves insulin sensitivity this should prompt a re-evaluation of the benefits of recommending a lower sodium intake in normotensive people. ..
  26. Oxidative Stress and Genetics of Prehypertension
    Shawna Nesbitt; Fiscal Year: 2004
    ..abstract_text> ..
  27. Hypertension Pharmacogenetics
    Julie Johnson; Fiscal Year: 2006
    ..This hypothesis will be tested for all four study drugs: atenolol, verapamil, hydrochlorothiazide and trandolapril...
  28. THROMBOTIC, INFLAMMATORY & GENE MARKERS OF CVD IN WOMEN
    Paul Ridker; Fiscal Year: 2002
    ....
  29. Symposium for Molecular and Therapeutic Insights in PKD
    Arlene Chapman; Fiscal Year: 2002
    ..Day 5 will be devoted to autosomal recessive kidney diseases and the last half day will be devoted to potential therapeutic strategies in cystic disorders of the kidney. ..
  30. Blood Pressure and Stimulant Medications in Children
    Jonathan Sorof; Fiscal Year: 2003
    ..If so, physicians who prescribe these medications must increased awareness of the need to monitor blood pressure carefully in these children. ..
  31. End-Organ Injury in Hypertensive Children
    Jonathan Sorof; Fiscal Year: 2003
    ..The proposed studies will add significantly to our ability to practice evidence-based medicine regarding the evaluation and management of hypertensive children. ..
  32. Intrarenal Augmentation of Angiotensinogen by Ang II
    Hiroyuki Kobori; Fiscal Year: 2010
    ..abstract_text> ..
  33. Androgens and Cardiovascular Risk in African Americans
    Bonita Falkner; Fiscal Year: 2005
    ..The results of this project can contribute to the development of prevention and earlier intervention strategies, including more specific therapeutic targets, for this high-risk minority population. ..
  34. Inflammation and Injury in Obesity Hypertension in African American Adolescents
    Bonita Falkner; Fiscal Year: 2010
    ..abstract_text> ..
  35. SECONDARY PREVENTION TRIAL OF VENOUS THROMBOSIS
    Paul Ridker; Fiscal Year: 2002
    ....
  36. EPIDEMIOLOGY OF BRAIN ABNORMALITIES IN FEBRILE SEIZURES
    Dale Hesdorffer; Fiscal Year: 2002
    ..Answers to these questions may improve the clinical management of subgroups of children at risk for long-term disability so that future at-risk children can benefit from early interventions. ..
  37. PPARGAMMA AND AII IN GLOMERULOSCLEROSIS
    Willa Hsueh; Fiscal Year: 2002
    ..abstract_text> ..
  38. EFFECT OF A COMPUTER BASED REMINDER SYSTEM ON CARDIOVASC
    Robert Phillips; Fiscal Year: 2002
    ..abstract_text> ..
  39. BIRTH WEIGHT EFFECT ON BLOOD PRESSURE IN LATE CHILDHOOD
    Bonita Falkner; Fiscal Year: 2001
    ..Alternatively, if post-natal/childhood parameters are the major determinants of later BP, then efforts should focus on effective preventive strategies in childhood, such as obesity. ..
  40. GENETICS OF SALT SENSITIVITY IN AFRICAN AMERICANS
    Jackson Wright; Fiscal Year: 2004
    ..To this end, careful analytic attention will be paid to the development of improved phenotype definition, as well as to the consideration of gene-gene and gene-environment interaction. ..
  41. Physiology and genetics of food procurement in rodents
    Neil Rowland; Fiscal Year: 2008
    ..The proposed studies will be the first to address the issue of behavioral change induced by anorectics under such conditions of simulated economic costs. [unreadable] [unreadable] [unreadable]..
  42. Gender & orthostatic intolerance: mechanisms and therapy
    Qi Fu; Fiscal Year: 2008
    ..The combination of advanced training in patient-oriented research and in-depth study of an important clinical problem will prepare me well for a career as an independent investigator. ..
  43. Pre-ESRD Syndrome in High Risk African American Adults
    ELIZABETH RIPLEY; Fiscal Year: 2006
    ..Improving treatment and outcomes in patients with renal failure are also of interest...
  44. Mechanisms of CVD and Endothelial Dysfunction in Obesity
    Willa Hsueh; Fiscal Year: 2006
    ..Early intervention is critical if we are to prevent these two major diseases, which may, indeed, be the same disease. ..
  45. NHLBI FAMILY BLOOD PRESSURE PROGRAM (GENOA)
    Stephen Turner; Fiscal Year: 2004
    ..The resulting synthesis of ideas and amassed data permits rigorous hypothesis testing not otherwise possible and will hasten understanding of the previously elusive genetic variation responsible for disease risk. ..
  46. Training CAM Clinical Investigators
    Richard Grimm; Fiscal Year: 2006
    ..Dr. Richard Grimm is Program Director. The Program will produce a highly trained cadre of clinical investigators with the knowledge and experience to becoming leading researchers in CAM. ..
  47. Web-Based Project Tracking to Enhance IRB Operations
    Henry Black; Fiscal Year: 2003
    ..abstract_text> ..
  48. MASTERS OF SCIENCE IN CLINICAL RESEARCH
    Henry Black; Fiscal Year: 2004
    ..Their success will be followed yearly by the Program Director of the Clinical Research Curriculum Award ..
  49. TGF-Beta, Glucose and Nephropathy in African Americans
    Bonita Falkner; Fiscal Year: 2007
    ..abstract_text> ..
  50. ANGIOTENSIN II AND MITOGEN ACTIVATED PROTEIN KINASE
    Willa Hsueh; Fiscal Year: 2003
    ..5) Investigate the mechanism of transcription at regulation of PAI-1 by hyperglycemia AngII, insulin and the MAPK inhibitor in cultured rat cardiac fibroblasts. ..
  51. TRAINING A NEW GENERATION OF CAM CLINICAL INVESTIGATORS
    Richard Grimm; Fiscal Year: 2006
    ..abstract_text> ..
  52. Family Blood Pressure Program (GenNet Network)
    Alan Weder; Fiscal Year: 2007
    ..unreadable] (End of Abstract) [unreadable] [unreadable]..
  53. Cue dependency with intravenous nutrients and nicotine
    Neil Rowland; Fiscal Year: 2007
    ..These studies may help to develop ways in conditioned preferences can be manipulated to prevent or treat certain addictive disorders, including overeating. [unreadable] [unreadable] [unreadable]..
  54. HARVARD OLDER AMERICANS INDEPENDENCE CENTER
    Lewis Lipsitz; Fiscal Year: 2006
    ..abstract_text> ..
  55. Angll and PPARy/LXR in Atherosclerosis
    Willa Hsueh; Fiscal Year: 2008
    ..4) Determine whether PPARgamma ligands or LXRaalpha ligands can induce regression of established atherosclerosis. ..
  56. HRCA/HARVARD RESEARCH NURSING HOME
    Lewis Lipsitz; Fiscal Year: 2008
    ..Our institutional commitments, longstanding collaboration among investigators, track record of productivity, administrative structure, and proven leadership all assure that this program will achieve its stated goals. ..