diltiazem

Summary

Summary: A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. It is also teratogenic.

Top Publications

  1. ncbi Landiolol, an ultra-short-acting β₁-blocker, more effectively terminates atrial fibrillation than diltiazem after open heart surgery: prospective, multicenter, randomized, open-label study (JL-KNIGHT study)
    Atsuhiro Sakamoto
    Department of Anesthesiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Circ J 76:1097-101. 2012
  2. ncbi Achromatopsia-associated mutation in the human cone photoreceptor cyclic nucleotide-gated channel CNGB3 subunit alters the ligand sensitivity and pore properties of heteromeric channels
    Changhong Peng
    Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology and Program in Neuroscience, Washington State University, Pullman, Washington 99164 6520, USA
    J Biol Chem 278:34533-40. 2003
  3. ncbi A new subunit of the cyclic nucleotide-gated cation channel in retinal rods
    T Y Chen
    Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, Maryland 21205
    Nature 362:764-7. 1993
  4. ncbi Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea
    YoungHee Kim
    School of Public Health, Seoul National University, Seoul, Republic of Korea
    Environ Int 33:370-5. 2007
  5. ncbi Effects of simvastatin on the pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, after oral and intravenous administration in rats: possible role of P-glycoprotein and CYP3A4 inhibition by simvastatin
    Dong Hyun Choi
    College of Medicine, Chosun University, Gwangju 501 759, Korea
    Pharmacol Rep 63:1574-82. 2011
  6. pmc Binding sites for bilobalide, diltiazem, ginkgolide, and picrotoxinin at the 5-HT3 receptor
    A J Thompson
    Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
    Mol Pharmacol 80:183-90. 2011
  7. ncbi The neuroprotective and anti-inflammatory effects of diltiazem in spinal cord ischaemia-reperfusion injury
    I Fansa
    Department of Cardiovascular Surgery, Faculty of Medicine, Mustafa Kemal University, Antakya Hatay, Turkey
    J Int Med Res 37:520-33. 2009
  8. ncbi Clinical benefits versus shortcomings of diltiazem once-daily in the chronotherapy of cardiovascular diseases
    Ugochukwu Ezeugo
    University of Alabama at Birmingham, Division of Preventive Medicine, Department of Internal Medicine, 1717 11th Avenue South, MT638, Birmingham, AL 35205, USA
    Expert Opin Pharmacother 10:485-91. 2009
  9. ncbi Inhibitory action of diltiazem on voltage-gated calcium channels in cone photoreceptors
    Jason Hart
    Neuroscience Research Group, University of Calgary, Calgary, Alta, Canada
    Exp Eye Res 76:597-604. 2003
  10. ncbi Absence of photoreceptor rescue with D-cis-diltiazem in the rd mouse
    Basil S Pawlyk
    Berman Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 43:1912-5. 2002

Detail Information

Publications319 found, 100 shown here

  1. ncbi Landiolol, an ultra-short-acting β₁-blocker, more effectively terminates atrial fibrillation than diltiazem after open heart surgery: prospective, multicenter, randomized, open-label study (JL-KNIGHT study)
    Atsuhiro Sakamoto
    Department of Anesthesiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Circ J 76:1097-101. 2012
    ..The aim of the present study was to investigate whether landiolol was effective for both rate control and conversion to normal sinus rhythm (NSR)...
  2. ncbi Achromatopsia-associated mutation in the human cone photoreceptor cyclic nucleotide-gated channel CNGB3 subunit alters the ligand sensitivity and pore properties of heteromeric channels
    Changhong Peng
    Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology and Program in Neuroscience, Washington State University, Pullman, Washington 99164 6520, USA
    J Biol Chem 278:34533-40. 2003
    ..of the channel, including decreased single channel conductance and decreased sensitivity to block by l-cis-diltiazem. Overall, these results suggest that the functional properties of cone CNG channels may be altered in patients ..
  3. ncbi A new subunit of the cyclic nucleotide-gated cation channel in retinal rods
    T Y Chen
    Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, Maryland 21205
    Nature 362:764-7. 1993
    ..The hetero-oligomeric channel is also highly sensitive to the blocker L-cis-diltiazem, like the native channel. This new protein thus seems to be another subunit of the native rod channel...
  4. ncbi Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea
    YoungHee Kim
    School of Public Health, Seoul National University, Seoul, Republic of Korea
    Environ Int 33:370-5. 2007
    ..the four most abundantly used pharmaceuticals in Korea, namely acetaminophen, carbamazepine, cimetidine, and diltiazem, and six sulfonamide related antibiotics, including sulfamethoxazole, sulfachlorpyridazine, sulfathiazole, ..
  5. ncbi Effects of simvastatin on the pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, after oral and intravenous administration in rats: possible role of P-glycoprotein and CYP3A4 inhibition by simvastatin
    Dong Hyun Choi
    College of Medicine, Chosun University, Gwangju 501 759, Korea
    Pharmacol Rep 63:1574-82. 2011
    ..of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, simvastatin, on the pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats...
  6. pmc Binding sites for bilobalide, diltiazem, ginkgolide, and picrotoxinin at the 5-HT3 receptor
    A J Thompson
    Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
    Mol Pharmacol 80:183-90. 2011
    Bilobalide (BB), ginkgolide B (GB), diltiazem (DTZ), and picrotoxinin (PXN) are 5-hydroxytryptamine type 3 (5-HT(3)) receptor antagonists in which the principal sites of action are in the channel...
  7. ncbi The neuroprotective and anti-inflammatory effects of diltiazem in spinal cord ischaemia-reperfusion injury
    I Fansa
    Department of Cardiovascular Surgery, Faculty of Medicine, Mustafa Kemal University, Antakya Hatay, Turkey
    J Int Med Res 37:520-33. 2009
    The protective effects of diltiazem were examined in a rabbit model of spinal cord ischaemia-reperfusion induced by infrarenal aortic occlusion for 30 min...
  8. ncbi Clinical benefits versus shortcomings of diltiazem once-daily in the chronotherapy of cardiovascular diseases
    Ugochukwu Ezeugo
    University of Alabama at Birmingham, Division of Preventive Medicine, Department of Internal Medicine, 1717 11th Avenue South, MT638, Birmingham, AL 35205, USA
    Expert Opin Pharmacother 10:485-91. 2009
    ..The introduction of chronotherapy (that is improving a drugs therapeutic efficacy by paralleling the drugs plasma levels to circadian rhythms) has recently become a focus of interest...
  9. ncbi Inhibitory action of diltiazem on voltage-gated calcium channels in cone photoreceptors
    Jason Hart
    Neuroscience Research Group, University of Calgary, Calgary, Alta, Canada
    Exp Eye Res 76:597-604. 2003
    The benzothiazepine, diltiazem, is commonly used as an inhibitor of vascular L-type Ca channels, and is a clinically important anti-anginal and antihypertensive medication...
  10. ncbi Absence of photoreceptor rescue with D-cis-diltiazem in the rd mouse
    Basil S Pawlyk
    Berman Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 43:1912-5. 2002
    Because of a previous report suggesting that D-cis-diltiazem slows retinal degeneration in rd mice, this study was undertaken to examine the effect of D-cis-diltiazem on photoreceptor structure and function in this line of mice.
  11. ncbi Calcium channel blocker D-cis-diltiazem does not slow retinal degeneration in the PDE6B mutant rcd1 canine model of retinitis pigmentosa
    S E Pearce-Kelling
    Baker Institute, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Mol Vis 7:42-7. 2001
    PURPOSE: D-cis-diltiazem, a calcium channel blocker, has been reported to enhance photoreceptor survival in the rd mouse, a model of retinitis pigmentosa (RP) resulting from mutation of the PDE6B gene...
  12. ncbi Diltiazem reduces retinal neovascularization in a mouse model of oxygen induced retinopathy
    R D Higgins
    Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007, USA
    Curr Eye Res 18:20-7. 1999
    To assess the effect of diltiazem, a calcium channel blocking agent, on oxygen induced retinopathy (OIR) in a mouse model using neovascular nuclei quantitation and a quantitative scoring system based on examining fluorescein perfused ..
  13. pmc The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model
    Christopher Semsarian
    Department of Genetics, Howard Hughes Medical Institute and Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    J Clin Invest 109:1013-20. 2002
    ..Early administration of the L-type Ca(2+) channel inhibitor diltiazem restores normal levels of these sarcoplasmic reticular proteins and prevents the development of pathology in ..
  14. ncbi Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse
    M Frasson
    Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine, médicale A, BP 426, 1 Place de l Hopital, Universite Louis Pasteur, 67091 Strasbourg, France
    Nat Med 5:1183-7. 1999
    ..We report that D-cis-diltiazem, a calcium-channel blocker that also acts at light-sensitive cGMP-gated channels, rescued photoreceptors and ..
  15. ncbi Subunit configuration of heteromeric cone cyclic nucleotide-gated channels
    Changhong Peng
    Department of Veterinary and Comparative Anatomy, Washington State University, P O Box 646520, Pullman, WA 99164, USA
    Neuron 42:401-10. 2004
    ..Together, these data support a preferred subunit arrangement for cone CNG channels (B3-B3-A3-A3) that is distinct from the 3A:1B configuration of rod channels...
  16. ncbi Physiologically based mechanistic modelling to predict complex drug-drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut - the effect of diltiazem on the time
    Karen Rowland Yeo
    Simcyp Limited, Blades Enterprise Centre, John Street, Sheffield S2 4SU, UK
    Eur J Pharm Sci 39:298-309. 2010
    To predict the magnitude of metabolic drug-drug interaction (mDDI) between triazolam and diltiazem and its primary metabolite N-desmethyldiltiazem (MA).
  17. ncbi Diltiazem poisoning treated with hyperinsulinemic euglycemia therapy and intravenous lipid emulsion
    Virginie Montiel
    Department of Intensive Care, Cliniques St Luc, 10 Avenue Hippocrate, Brussels, Belgium
    Eur J Emerg Med 18:121-3. 2011
    ..An 18-year-old healthy woman was admitted 8 h after the voluntary ingestion of sustained-release diltiazem (3600 mg), with severe hypotension refractory to fluid therapy, calcium salts, and high-dose norepinephrine (6...
  18. ncbi Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina
    A Gerstner
    Institut fur Pharmakologie und Toxikologie der Technischen Universitat Munchen, 80802 Munchen, Germany
    J Neurosci 20:1324-32. 2000
    ..weakened the outward rectification in the presence of extracellular Ca(2+), increased the sensitivity for L-cis diltiazem, and enhanced the cAMP efficacy of the channel...
  19. ncbi Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial
    Bernard R Chaitman
    Department of Medicine, Division of Cardiology, St Louis University School of Medicine, St Louis, MO, USA
    JAMA 291:309-16. 2004
    ....
  20. ncbi Noscapine and diltiazem augment taxol and radiation-induced S-phase arrest and clonogenic death of C6 glioma in vitro
    Meric A Altinoz
    Golden Horn Halic University, Capa, Istanbul 34390, Turkey
    Surg Neurol 65:478-84; discussion 485. 2006
    ..Noscapine is an opioid antitussive, which acts anti cancer via blocking microtubule dynamics. Diltiazem is a calcium channel-blocking cardiac antiarrythmic, which also blocks tumor growth and P-glycoprotein.
  21. ncbi Development of oral controlled-release tablet formulations based on diltiazem-carrageenan complex
    M C Bonferoni
    Department of Pharmaceutical Chemistry, University of Pavia, Pavia, Italy
    Pharm Dev Technol 9:155-62. 2004
    b>Diltiazem HCl and lambda carrageenan react in distilled water to give a slightly soluble interaction product...
  22. ncbi The effect on heart rate of combining single-dose fingolimod with steady-state atenolol or diltiazem in healthy subjects
    John M Kovarik
    Novartis Pharma, Building WSJ 210 423, 4002, Basel, Switzerland
    Eur J Clin Pharmacol 64:457-63. 2008
    ..The authors determined the effect of combining a single dose of fingolimod with steady-state atenolol or diltiazem on heart rate and mean arterial pressure.
  23. ncbi Intravenous lipid emulsion therapy for sustained release diltiazem poisoning: a case report
    Ben J Wilson
    Department of Medicine, University of Calgary, Calgary, Alberta
    J Popul Ther Clin Pharmacol 19:e218-22. 2012
    We present a case of refractory cardiogenic shock secondary to sustained release diltiazem poisoning.  Intravenous lipid emulsion therapy was initiated approximately 13 hours after ingestion...
  24. ncbi Modulation of drug release rate of diltiazem-HCl from hydrogel matrices of succinic acid-treated ispaghula husk
    M C Gohel
    Department of Pharmaceutical Technology, L M College of Pharmacy, Navrangpura, Ahmedabad, India
    Pharm Dev Technol 5:375-81. 2000
    The feasibility of using succinic acid-treated ispaghula husk in matrix-based tablets of diltiazem-HCl was investigated. The sample prepared using 4:1 weight ratio of ispaghula husk to succinic acid showed improved swelling and gelling...
  25. ncbi Pharmacokinetic-pharmacodynamic modeling of diltiazem in spontaneously hypertensive rats: a microdialysis study
    Facundo M Bertera
    Department of Pharmacology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, C1113AAD Buenos Aires, Argentina
    J Pharmacol Toxicol Methods 56:290-9. 2007
    ..work was to study the applicability of a modified E(max) pharmacodynamic model for the pharmacokinetic-pharmacodynamic (PK-PD) modeling of diltiazem in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto (WKY) rats.
  26. ncbi Critical care management of verapamil and diltiazem overdose with a focus on vasopressors: a 25-year experience at a single center
    Michael Levine
    Department of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, AZ, USA
    Ann Emerg Med 62:252-8. 2013
    Verapamil or diltiazem overdose can cause severe morbidity and death, and there exist limited human data describing management and outcome of a large number of such patients...
  27. ncbi Systematic review of the use of topical diltiazem compared with glyceryltrinitrate for the nonoperative management of chronic anal fissure
    M S Sajid
    Department of Colorectal Surgery, Worthing Hospital, Worthing, UK
    Colorectal Dis 15:19-26. 2013
    The study analyzed clinical trials investigating the effectiveness of diltiazem (DTZ) and glyceryltrinitrate (GTN) for the nonsurgical management of chronic anal fissure (CAF).
  28. ncbi Multivariate statistical approach to optimizing sustained-release tablet formulations containing diltiazem hydrochloride as a model highly water-soluble drug
    Shingo Kikuchi
    Department of Pharmaceutics, Hoshi University, Tokyo 142 8501, Japan
    Int J Pharm 386:149-55. 2010
    A multivariate statistical technique was applied to designing a tablet for the sustained release over 24h of diltiazem hydrochloride, a model highly water-soluble drug...
  29. ncbi Lessons learnt in the pharmacokinetic analysis of the effect of haemoperfusion for acute overdose with sustained-release diltiazem
    D M Roberts
    Burns, Trauma and Critical Care Research Centre, University of Queensland, Butterfield Street, Herston, Australia
    Anaesthesia 63:714-8. 2008
    The effect of charcoal haemoperfusion on the pharmacokinetics of diltiazem is described in a patient with severe clinical toxicity following acute overdose...
  30. ncbi Lipid emulsion therapy in cardiodepressive syndrome after diltiazem overdose--case report
    Cristina Bologa
    Internal Medicine Department, II Internal Medical Clinic, Sf Spiridon Clinical Emergency Hospital, Gr T Popa University of Medicine and Pharmacy, Iasi, Romania
    Am J Emerg Med 31:1154.e3-4. 2013
    We present a case of diltiazem overdose in which the patient ingested 5.6 g in an apparent suicide attempt. She was admitted in the emergency department 2 hours postingestion with cardiodepressive syndrome...
  31. ncbi Is vitamin C superior to diltiazem for radial artery vasodilation in patients awaiting coronary artery bypass grafting?
    George E Drossos
    Department of Cardiothoracic Surgery, University of Ioannina School of Medicine, Ioannina, Greece
    J Thorac Cardiovasc Surg 125:330-5. 2003
    ..the vasodilating effects of vitamin C on the radial arteries of healthy subjects and to assess whether vitamin C is superior in this regard to diltiazem, a commonly used vasodilator in coronary artery bypass using radial conduits.
  32. ncbi Treatment of stable angina with low dose diltiazem in combination with the metabolic agent trimetazidine
    S C Manchanda
    Department of Cardiology, All India Institute of Medical Sciences, Ansari Nagar, 110 029, New Delhi, India
    Int J Cardiol 88:83-9. 2003
    ..This study investigates the efficacy and acceptability of low dose diltiazem in combination with trimetazidine for the treatment of stable angina.
  33. ncbi Postoperative outcome of patients undergoing lung resection presenting with new-onset atrial fibrillation managed by amiodarone or diltiazem
    Antonio Bobbio
    Department of Surgical Science, Unit of Thoracic Surgery, University of Parma, Parma, Italy
    Eur J Cardiothorac Surg 31:70-4. 2007
    ..The postoperative course of AF was also evaluated in relation to either amiodarone or diltiazem employed as anti-arrhythmic agents.
  34. ncbi Third-degree AV block from extended-release diltiazem ingestion in a nine-month-old
    Brandon K Wills
    Department of Emergency Medicine, Madigan Army Medical Center, Tacoma, Washington 98431, USA
    J Emerg Med 38:328-31. 2010
    ..A 9-month-old girl was found playing with tablets of extended-release diltiazem 120 mg...
  35. ncbi A prospective, randomized, double-blind study comparing the efficacy of diltiazem, glyceryl trinitrate, and lidocaine for the treatment of anal fissure in children
    Muazez Cevik
    Cocuk Cerrahisi Anabilim Dali, Harran Universitesi Tip Fakultesi, Morfoloji Binasi, Yenisehir Kampusu, 63300, Sanliurfa, Turkey
    Pediatr Surg Int 28:411-6. 2012
    ..Although adult patients with AF have been treated successfully using diltiazem, it has not been studied in children...
  36. ncbi Effect of combined dopamine and diltiazem on renal function after cardiac surgery
    Senol Yavuz
    Department of Cardiovascular Surgery, Bursa Yuksek Ihtisas Teaching and Research Hospital, Bursa, Turkey
    Med Sci Monit 8:PI45-50. 2002
    In order to evaluate the effect of the combined use of dopamine and diltiazem on renal function in patients undergoing coronary artery bypass grafting (CABG), we conducted a prospective randomized study.
  37. ncbi Discovery of novel and cardioselective diltiazem-like calcium channel blockers via virtual screening
    Emanuele Carosati
    Dipartimento di Chimica, Universita degli Studi di Perugia, Via Elce di Sotto 10, 06123 Perugia, Italia
    J Med Chem 51:5552-65. 2008
    ..L-type calcium channels (LTCCs), ligand-based virtual screening was applied with a specific interest toward the diltiazem binding site. Roughly 50000 commercially available compounds served as a database for screening...
  38. ncbi Fascioscapulohumeral muscular dystrophy: a progressive degenerative disease that responds to diltiazem
    D L Lefkowitz
    Department of Medical Microbiology and Immunology, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    Med Hypotheses 65:716-21. 2005
    ..The present investigators have noted that some individuals with FSHD benefit from a regimen of diltiazem, a Ca2+ channel blocker...
  39. ncbi Effects of diltiazem retard on ambulatory blood pressure and heart rate variability in patients with essential hypertension
    Y Kawano
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
    Blood Press Monit 5:181-5. 2000
    ..Dihydropyridine calcium antagonists increase heart rate due to reflex activation of the sympathetic nervous system, although these effects are less obvious for long-acting agents...
  40. pmc Effects of diltiazem and propafenone on the inactivation and recovery kinetics of fKv1.4 channel currents expressed in Xenopus oocytes
    Dong Zhang
    Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China
    Acta Pharmacol Sin 32:465-77. 2011
    To investigate the effects of diltiazem, an L-type calcium channel blocker, and propafenone, a sodium channel blocker, on the inactivation and recovery kinetics of fKv1...
  41. ncbi An investigation of pulsatile release tablets with ethylcellulose and Eudragit L as film coating materials and cross-linked polyvinylpyrrolidone in the core tablets
    T Y Fan
    Department of Pharmacy, Peking University School of Pharmaceutical Sciences, 100083, Beijing, China
    J Control Release 77:245-51. 2001
    ..The release of diltiazem hydrochloride (DIL) as a model drug in the core tablets was investigated in vitro...
  42. ncbi Effect of different durations and formulations of diltiazem on the single-dose pharmacokinetics of midazolam: how long do we go?
    Evan J Friedman
    Merck and Co, Inc, Whitehouse Station, New Jersey, USA
    J Clin Pharmacol 51:1561-70. 2011
    ..b>Diltiazem interaction studies assess a given compound's sensitivity to moderate CYP3A inhibition...
  43. ncbi A combination of nonionic surfactants and iontophoresis to enhance the transdermal drug delivery of ondansetron HCl and diltiazem HCl
    Sérgio M C Silva
    Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, Coimbra, Portugal
    Eur J Pharm Biopharm 80:663-73. 2012
    ..as skin permeation enhancers in the transdermal drug delivery of two drugs: ondansetron hydrochloride and diltiazem hydrochloride, formulated as hydrogels. The enhancers are used alone, or in combination with iontophoresis (0...
  44. ncbi Diltiazem overdose: a role for high-dose insulin
    Neil Abeysinghe
    Department of Anaesthesia, The Shrewsbury and Telford Hospital NHS Trust, Princess Royal Hospital, Apley Castle, Telford TF1 6TF, UK
    Emerg Med J 27:802-3. 2010
    ..This case supports the use of rescue hyperinsulinaemic euglycaemia in patients with an overdose of calcium channel blockers who remain hypotensive despite standard pharmacological measures...
  45. ncbi A comparison of the effects of diltiazem and glyceryl trinitrate ointment in the treatment of chronic anal fissure: a randomized clinical trial
    U K Shrivastava
    Department of Surgery, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, 110095, India
    Surg Today 37:482-5. 2007
    ..In recent years, various medical therapies have been used for the treatment of chronic anal fissure without fear of incontinence...
  46. ncbi Effect of glycyrrhizic acid on protein binding of diltiazem, verapamil, and nifedipine
    Kyoung Jin Lee
    Locus Pharmaceuticals, Inc, Blue Bell, PA, USA
    Arch Pharm Res 27:978-83. 2004
    The effects of glycyrrhizic acid (GLZ) on protein binding of diltiazem, verapamil, and nifedipine were investigated...
  47. ncbi The use of diltiazem for treating rapid atrial fibrillation in the out-of-hospital setting
    H E Wang
    Department of Emergency Medicine, Christiana Care Health System, Newark, DE, USA
    Ann Emerg Med 37:38-45. 2001
    We sought to evaluate the use of intravenous diltiazem for treatment of rapid atrial fibrillation or flutter (RAF) in the out-of-hospital setting.
  48. ncbi Development of controlled-release buccoadhesive hydrophilic matrices of diltiazem hydrochloride: optimization of bioadhesion, dissolution, and diffusion parameters
    Bhupinder Singh
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Drug Dev Ind Pharm 28:431-42. 2002
    ..b>Diltiazem hydrochloride (DLZ) is also reported to have low oral bioavailability due to an extensive hepatic first-pass ..
  49. ncbi Effects of diltiazem on in vitro cardiovascular actions of crude venom obtained from Okinawan box-jellyfish (Habu-kurage), Chiropsalmus quadrigatus
    M Sakanashi
    Anaesth Intensive Care 30:570-7. 2002
    ..These increases in contractions were significantly inhibited by diltiazem and did not show tachyphylaxis...
  50. ncbi Development and release mechanism of diltiazem HCl prolonged release matrix tablets
    Harikrishna Boyapally
    Pharmaceutical Sciences, Greenwich University, Medway Campus, Chatham Maritime, Kent, UK
    Drug Deliv 16:67-74. 2009
    A coated matrix tablet formulation has been used to develop controlled release diltiazem HCl (DIL) tablets. The developed drug delivery system provided prolonged drug release rates over a defined period of time...
  51. ncbi Effect of diltiazem on retention and retrieval of memory in young and aged mice
    A Arzi
    Physiology Research Center, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran
    Pak J Biol Sci 13:1042-6. 2010
    b>Diltiazem (DTZ) is widely used in the prophylaxis of hypertension and treatment of angina...
  52. ncbi Evaluation of novel starch acetate-diltiazem controlled release tablets in healthy human volunteers
    Ossi Korhonen
    Department of Pharmaceutics, University of Kuopio, FIN 70211 Kuopio, Finland
    J Control Release 95:515-20. 2004
    ..Three starch acetate tablet formulations with different in vitro release rates for diltiazem (fast, moderate and slow) were developed...
  53. ncbi Use of coated microtubular halloysite for the sustained release of diltiazem hydrochloride and propranolol hydrochloride
    S R Levis
    Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, Trinity College, University of Dublin, Dublin 2, Ireland
    Int J Pharm 253:145-57. 2003
    Halloysite is a naturally occurring microtubular aluminosilicate mineral. The highly water soluble cationic drug, diltiazem HCl, was shown to bind to the polyanionic surfaces of the material to achieve a slight sustained release effect ..
  54. ncbi Influence of centrally administered diltiazem on behavioural responses, clinical symptoms, reticulo-ruminal contractions and plasma catecholamine level after experimentally induced duodenal distension in sheep
    B F Kania
    Experimental and Clinical Physio Pharmacological Laboratory, Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159, 02 776 Warsaw, Poland
    Res Vet Sci 90:291-7. 2011
    ..Present study examined the role of VGCC blocker - diltiazem administered icv (0.25, 0.5, 1.0 and/or 2...
  55. ncbi Diltiazem attenuates oxidative stress in diabetic rats
    Muragundla Anjaneyulu
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Ren Fail 27:335-44. 2005
    ..The present study was thus designed to examine the effect of a nondihydropyridine calcium channel blocker, diltiazem, on renal function, oxidative stress, and nitric oxide (NO) release in streptozotocin (STZ)-induced diabetic ..
  56. ncbi Effects of resveratrol on the pharmacokinetics of diltiazem and its major metabolite, desacetyldiltiazem, in rats
    Soon Pyo Hong
    College of Medicine, Chosun University, Gwangju, Republic of Korea
    Cardiovasc Ther 26:269-75. 2008
    ..purpose of this study was to investigate the effects of resveratrol, an antioxidant, on the pharmacokinetics of diltiazem and its active metabolite, desacetyldiltiazem, in rats...
  57. ncbi [Nephrotoxicity of tacrolimus and preventive effect of diltiazem: experiment with rats]
    Ye Hui Chen
    Department of Urology, First Municipal People s Hospital of Guangzhou, Guangzhou 510180, China
    Zhonghua Yi Xue Za Zhi 89:704-8. 2009
    To study the nephrotoxicity tacrolimus (FK506) at the therapeutic dose the preventive effect of diltiazem (Dil), a calcium antagonist against the FK506-induced pathological changes.
  58. ncbi Enhanced oral exposure of diltiazem by the concomitant use of naringin in rats
    Jun Shik Choi
    College of Pharmacy, Chosun University, 375 Su suk Dong, Dong Gu, Gwangju, Republic of Korea
    Int J Pharm 305:122-8. 2005
    The present study aims to investigate the effect of naringin, a flavonoid, on the pharmacokinetics of diltiazem and its active metabolite, desacetyldiltiazem, in rats...
  59. ncbi Diltiazem did not induce gingival overgrowth in rats. A clinical, histological and histometric analysis
    Fernanda de Oliveira Bello Corrêa
    Department of Diagnosis and Surgery, School of Dentistry of Araraquara, Sao Paulo State University
    Braz Oral Res 19:163-8. 2005
    ..However, there are few studies in humans or animals that evaluated the effect of diltiazem on gingival tissues...
  60. ncbi Effect of the calcium channel blockers nifedipine and diltiazem on pentylenetetrazole kindling-provoked amnesia in rats
    M G Genkova-Papazova
    Laboratory of CNS Pharmacology, Institute of Physiology, Bulgarian Academy of Sciences, Acad G Bonchev Str, bl 23, 1113, Sofia, Bulgaria
    Eur Neuropsychopharmacol 11:91-6. 2001
    ..we examined the effect of post-training administered calcium channel blockers nifedipine (10 and 40 mg/kg) and diltiazem (10 and 30 mg/kg) on amnesia induced by PTZ kindling in shuttle-box- and step-down-trained rats...
  61. ncbi Calcium chloride before i.v. diltiazem in the management of atrial fibrillation
    Tom Kolkebeck
    959th Surgical Operations Squadron, Wilford Hall Medical Center, San Antonio, Texas, USA
    J Emerg Med 26:395-400. 2004
    b>Diltiazem is commonly used to treat atrial fibrillation or flutter (AFF) with rapid ventricular response (RVR)...
  62. pmc Effects of KRN2391, nicorandil and diltiazem on the changes in the electrocardiogram caused by endothelin-1 in anaesthetized rats
    K Harada
    Pharmaceutical Research Laboratory, Kirin Brewery Co Ltd, Gunma, Japan
    Br J Pharmacol 109:679-84. 1993
    ..caused by endothelin-1 (ET-1) was studied in anaesthetized rats and compared with the effects of nicorandil and diltiazem. In addition, the effect of KRN2391 on the action potential of guinea-pig papillary muscle was studied. 2...
  63. ncbi Diltiazem in acute myocardial infarction treated with thrombolytic agents: a randomised placebo-controlled trial. Incomplete Infarction Trial of European Research Collaborators Evaluating Prognosis post-Thrombolysis (INTERCEPT)
    W E Boden
    Veterans Affairs Medical Center, Syracuse, New York, USA
    Lancet 355:1751-6. 2000
    b>Diltiazem reduces non-fatal reinfarction and refractory ischaemia after non-Q-wave myocardial infarction, an acute coronary syndrome similar to the incomplete infarction that occurs after successful reperfusion...
  64. ncbi Calcium antagonists, diltiazem and nifedipine, protect broilers against low temperature-induced pulmonary hypertension and pulmonary vascular remodeling
    Ying Yang
    College of Animal Science and Technology, China Agricultural University, Beijing, China
    Anim Sci J 81:494-500. 2010
    This study was designed to determine whether calcium antagonists, diltiazem and nifedipine, can depress low temperature-induced pulmonary hypertension (PH) in broilers (also known as ascites) and to characterize their efficacy on ..
  65. ncbi Acute cardiovascular effects of diltiazem in anesthetized dogs with induced atrial fibrillation
    M Miyamoto
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210-1092, USA
    J Vet Intern Med 15:559-63. 2001
    ..In a previous study, we determined the dosage of intravenously administered diltiazem necessary to reduce ventricular response (VR), cardiac output (CO), and mean systemic arterial pressure (P(Ao)) ..
  66. ncbi Pharmacokinetic interaction between fluvastatin and diltiazem in rats
    Jun Shik Choi
    College of Pharmacy, Chosun University, 375 Seosuk dong, Dong Gu, Gwangju, Korea
    Biopharm Drug Dispos 27:437-41. 2006
    The present study aimed to investigate the effect of fluvastatin on the pharmacokinetics of diltiazem in rats...
  67. ncbi The effect of oral diltiazem on airway reactivity to methacholine and exercise in subjects with mild intermittent asthma
    E Harman
    Department of Pharmacy Practice, College of Pharmacy, University of Florida, Gainesville 32610
    Am Rev Respir Dis 136:1179-82. 1987
    The effect of increasing doses of oral diltiazem on airway reactivity to methacholine was evaluated in 10 volunteers with mild asthma...
  68. ncbi Effect of atorvastatin on the pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats
    Soon Pyo Hong
    College of Medicine, Chosun University, Gwangju 501 759, Korea
    Arch Pharm Res 30:90-5. 2007
    ..study was to investigate the effect of atorvastatin, HMG-CoA reductase inhibitor, on the pharmacokinetics of diltiazem and its active metabolite, desacetyldiltiazem, in rats...
  69. ncbi Inhibition of MDR1 activity and induction of apoptosis by analogues of nifedipine and diltiazem: an in vitro analysis
    Maurizio Viale
    Istituto Nazionale per la Ricerca sul Cancro, S C Terapia Immunologica, L go R Benzi 10, 16132, Genova, Italy
    Invest New Drugs 29:98-109. 2011
    ..Moreover, together with compound 3 (the diltiazem-like 8-(4-chlorophenyl)-5-methyl-8-[(2Z)-pent-2-en-1-yloxy]-8H-[1,2,4]oxadiazolo[3,4-c][1,4]thiazin-3-one) we ..
  70. pmc Comparison of the effectiveness of intravenous diltiazem and metoprolol in the management of rapid ventricular rate in atrial fibrillation
    C Demircan
    Uludag University Medical Faculty Hospital, Bursa, Turkey
    Emerg Med J 22:411-4. 2005
    To compare the effectiveness of intravenous (IV) diltiazem and metoprolol in the management of rapid ventricular rate in atrial fibrillation (AF).
  71. ncbi In vivo performance of controlled release pellets of diltiazem HCl
    - Nisarur-ur-Rahman
    Department of Pharmacy, Islamia University, Bahawalpur, Pakistan
    Pak J Pharm Sci 18:44-8. 2005
    The test formulation of controlled release diltiazem pellets was evaluated in vivo, in comparison with Herbesser SR. Six healthy volunteers participated in the study, conducted according to a randomized, two-way crossover study design...
  72. pmc Development and in vitro evaluation of an oral floating matrix tablet formulation of diltiazem hydrochloride
    Manoj N Gambhire
    Department of Pharmaceutics, Bharati Vidyapeeth s College of Pharmacy, C B D, Navi Mumbai 400 614, Maharashtra, India
    AAPS PharmSciTech 8:E73. 2007
    The purpose of this research was to prepare a floating drug delivery system of diltiazem hydrochloride (DTZ). Floating matrix tablets of DTZ were developed to prolong gastric residence time and increase its bioavailability...
  73. ncbi Prehospital pharmacology: diltiazem
    Benjamin Zachar
    Albert Einstein Medical Center, Philadelphia, PA, USA
    Emerg Med Serv 35:53-7. 2006
  74. ncbi Effect of diltiazem and methylene blue on human sperm motility, viability and cervical mucus penetration: potential use as vas irrigants at the time of vasectomy
    Barbara L Wood
    Sperm Biology and Contraceptive Research Laboratory, CONRAD Program, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Contraception 67:241-5. 2003
    ..b>Diltiazem, an anti-arrhythmic drug, and methylene blue, an agent commonly used in vasography, showed the most promising ..
  75. ncbi Hydrocolloid carriers with filler inclusion for diltiazem hydrochloride release
    A Gal
    Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Faculty of Agricultural, Food and Environmental Quality Sciences, Rehovot, 76100, Israel
    J Pharm Sci 96:168-78. 2007
    ..Release profiles of diltiazem hydrochloride from different carriers were obtained during immersion in dissolution medium...
  76. ncbi Studies on interactions between functional foods or dietary supplements and medicines. I. Effects of Ginkgo biloba leaf extract on the pharmacokinetics of diltiazem in rats
    Noriaki Ohnishi
    Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto, Japan
    Biol Pharm Bull 26:1315-20. 2003
    ..leaf extract (GBE), one of the most widely used herbal dietary supplements in Japan, on the pharmacokinetics of diltiazem (DTZ), a typical probe of cytochrome P450 (CYP) 3A, were examined in rats...
  77. ncbi Effect of hydrophilic polymers on the release of diltiazem hydrochloride from elementary osmotic pumps
    D Prabakaran
    Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dr Harisingh Gour University, Sagar, MP 470 003, Sagar, India
    Int J Pharm 259:173-9. 2003
    b>Diltiazem hydrochloride (DLTZ) is a freely water-soluble drug, because of its higher aqueous solubility, the suitability of the drug with elementary osmotic pumps is restricted...
  78. ncbi Stereoselective behavior of the functional diltiazem analogue 1-[(4-chlorophenyl)sulfonyl]-2-(2-thienyl)pyrrolidine, a new L-type calcium channel blocker
    Emanuele Carosati
    Dipartimento di Chimica, Universita degli Studi di Perugia, 06123 Perugia, Italy
    J Med Chem 52:6637-48. 2009
    ..a recently described blocker of cardiovascular L-type calcium channels that binds to the diltiazem site...
  79. ncbi Facilitatory effects of diltiazem on dopamine release in the central nervous system. Focus on interactions with D2 autoreceptors and guanosine triphosphate binding proteins
    K Tsuda
    Neurochemistry Research Laboratories, New York University Medical Center, NY
    Am J Hypertens 5:642-7. 1992
    The purpose of the present study was to investigate the effects of a Ca antagonist (diltiazem) on dopamine release in the central nervous system...
  80. ncbi Excessive activation of cyclic nucleotide-gated channels contributes to neuronal degeneration of photoreceptors
    Géraldine Vallazza-Deschamps
    Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine, INSERM U 592, Universite Pierre et Marie Curie, Bâtiment Kourilsky 6ème étage, 75571 Paris Cedex 12, France
    Eur J Neurosci 22:1013-22. 2005
    ..assess the role of cGMP-gated channels in this cGMP toxicity, the Ca(2+) channel blockers verapamil and L- and D-diltiazem, which block cGMP-gated channels with different efficacies, were applied to in vitro animal models of ..
  81. ncbi Comparison of response to serotonin of radial artery grafts and internal mammary grafts to native coronary arteries and the effect of diltiazem
    G Sperti
    Institute of Cardiology and Cardiac Surgery, and the Department of Anesthesia, Catholic University, Rome, Italy
    Am J Cardiol 83:592-6, A8. 1999
    ..of serotonin in 22 consecutive patients 1 year after the operation, subsequently evaluating the effect of diltiazem in 9 patients...
  82. ncbi Effects of diltiazem compared with nicardipine on diaphragmatic fatigability in vivo
    Y Fujii
    Eur J Anaesthesiol 20:575-6. 2003
  83. ncbi Protection of Swiss albino mice against whole-body gamma irradiation by diltiazem
    V Nunia
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302 004, India
    Br J Radiol 80:77-84. 2007
    The aim of the present study was to evaluate the radioprotective effect of diltiazem (DTZ) on Swiss albino mice exposed to gamma radiation...
  84. pmc Effects of itraconazole and diltiazem on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein
    Mikiko Shimizu
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, and Department of Pharmacy, Hirosaki University Hospital, Japan
    Br J Clin Pharmacol 61:538-44. 2006
    ..Our objective was to evaluate the possible effects of two P-glycoprotein inhibitors, itraconazole and diltiazem, on the pharmacokinetics of fexofenadine, a putative probe of P-glycoprotein activity in vivo, and compare the ..
  85. ncbi Differential myolysis of myocardium and skeletal muscle in hamsters with dilated cardiomyopathy: beneficial protective effect of diltiazem
    Yosuke Kato
    Pathophysiological Laboratory Sciences, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Circ J 70:1497-502. 2006
    ....
  86. ncbi Calcium channel blocker (diltiazem) inhibits apoptosis of vascular smooth muscle cell exposed to high glucose concentration through lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) pathway
    Achmad Rudijanto
    Department of Internal Medicine, Faculty of Medicine Brawijaya University dr Syaiful Anwar Hospital, Jl Veteran, Malang 65145, Indonesia
    Acta Med Indones 42:59-65. 2010
    to examine the role of diltiazem in the prevention of VSMC apoptosis exposed to high glucose through inhibition of LOX-1 expression.
  87. ncbi Case report: delirium due to a diltiazem-fentanyl CYP3A4 drug interaction
    Tomer T Levin
    Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Gen Hosp Psychiatry 32:648.e9-648.e10. 2010
    Fentanyl and diltiazem are frequently used medications. Diltiazem inhibits cytochrome P450 3A4 isoenzymes. This can suppress fentanyl metabolism.
  88. ncbi Pharmacokinetic and pharmacodynamic interactions between diltiazem and methylprednisolone in healthy volunteers
    Brent M Booker
    Department of Pharmaceutical Sciences, State University of New York at Buffalo, 14260, USA
    Clin Pharmacol Ther 72:370-82. 2002
    The pharmacokinetics and pharmacodynamics after administration of methylprednisolone alone, diltiazem alone, and both drugs jointly were assessed in healthy volunteers.
  89. ncbi The long-term results of diltiazem treatment for anal fissure
    G F Nash
    Poole Hospital, Dorset, UK
    Int J Clin Pract 60:1411-3. 2006
    The effects of diltiazem treatment on symptoms of chronic anal fissures and their long-term outcome were investigated...
  90. ncbi Differences in protective profiles of diltiazem isomers in ischemic and reperfused guinea pig hearts
    Ryuichi Sato
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
    Eur J Pharmacol 434:125-31. 2002
    The effects of L-cis and D-cis diltiazem on the extracellular potassium concentration ([K(+)]e), pH and cardiac function were compared in ischemic guinea pig hearts...
  91. ncbi Effect of calcium channel antagonist diltiazem and calcium ionophore A23187 on cyclosporine A-induced apoptosis of renal tubular cells
    Chi Hung Cheng
    Section of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan
    FEBS Lett 516:191-6. 2002
    ..In this study, we have used Madin-Darby canine kidney tubular cells as a model to examine the effect of diltiazem, a calcium channel antagonist, on CsA-induced apoptosis...
  92. ncbi Topical diltiazem ointment in the treatment of chronic anal fissure
    J S Knight
    Department of Colorectal Surgery, Royal Berkshire and Battle Hospitals, Oxford Road, Reading RG30 1AG, UK
    Br J Surg 88:553-6. 2001
    ..In this study the use of topical 2 per cent diltiazem ointment has been investigated as an alternative method of chemical sphincterotomy...
  93. ncbi Semiphysiologically based pharmacokinetic models for the inhibition of midazolam clearance by diltiazem and its major metabolite
    Xin Zhang
    Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Purdue University, Indianapolis, Indiana, USA
    Drug Metab Dispos 37:1587-97. 2009
    Prediction of the extent and time course of drug-drug interactions (DDIs) between the mechanism-based inhibitor diltiazem (DTZ) and the CYP3A4 substrate midazolam (MDZ) is confounded by time- and concentration-dependent clearance of the ..
  94. ncbi Transfer of high sensitivity for benzothiazepines from L-type to class A (BI) calcium channels
    S Hering
    Institut fur Biochemische Pharmakologie, University of Innsbruck, Peter Mayr Strasse 1, A 6020 Innsbruck, Austria
    J Biol Chem 271:24471-5. 1996
    To investigate the molecular basis of the calcium channel block by diltiazem, we transferred amino acids of the highly sensitive and stereoselective L-type (alpha1S or alpha1C) to a weakly sensitive, nonstereoselective class A (alpha1A) ..
  95. ncbi Molecular determinants of Ca2+ potentiation of diltiazem block and Ca2+-dependent inactivation in the pore region of cav1.2
    Nejmi Dilmac
    Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana, USA
    Mol Pharmacol 64:491-501. 2003
    b>Diltiazem block of Cav1.2 is frequency-dependent and potentiated by Ca2+. We examined the molecular determinants of these characteristics using mutations that affect Ca2+ interactions with Cav1.2. Mutant and wild-type (WT) Cav1...
  96. ncbi Effect of diltiazem on kidney function during laparoscopic surgery
    Ji Young Kim
    Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea
    Surg Endosc 23:1785-90. 2009
    ..This study was designed to investigate the effect of diltiazem on acute kidney injury during positive pneumoperitoneum in patients undergoing laparoscopic surgery.
  97. ncbi Molecular determinants of diltiazem block in domains IIIS6 and IVS6 of L-type Ca(2+) channels
    G H Hockerman
    Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, USA
    Mol Pharmacol 58:1264-70. 2000
    The benzothiazepine diltiazem blocks ionic current through L-type Ca(2+) channels, as do the dihydropyridines (DHPs) and phenylalkylamines (PAs), but it has unique properties that distinguish it from these other drug classes...
  98. ncbi Cardiovascular and pharmacokinetic interactions between nicorandil and adjunctive propranolol, atenolol or diltiazem in conscious dogs
    S J Humphrey
    Pharmacology Department, Pharmacia and Upjohn, Inc, Kalamazoo, Michigan, USA
    Methods Find Exp Clin Pharmacol 20:779-91. 1998
    ..beta-adrenergic receptor antagonists propranolol (PRO) and atenolol (ATN) and with the calcium channel blocker diltiazem (DTZ) to determine their cardiovascular and pharmacokinetic interactions...
  99. ncbi pH-dependent block of the L-type Ca2+ channel current by diltiazem in human mesenteric arterial myocytes
    S V Smirnov
    Department of Pharmacology, The Guy s, King s and St Thomas Schools of Medicine, St Thomas Campus, King s College, London, UK
    Eur J Pharmacol 360:81-90. 1998
    Inhibition of the L-type Ca2+ channel current (IBa) by diltiazem was characterised in human mesenteric arterial myocytes. External (pHo) and internal (pHi) pH was varied to alter the proportion of drug in charged and neutral forms...
  100. ncbi A prospective randomized trial of diltiazem and glyceryltrinitrate ointment in the treatment of chronic anal fissure
    K Bielecki
    Department Surgery, Medical Centre for Postgraduate Education, Orlowski Hospital, 231 Czerniakowska str 00 416, Warsaw, Poland
    Colorectal Dis 5:256-7. 2003
    The aim of this study was to compare prospectively diltiazem with GTN ointment in the treatment of anal fissure.
  101. ncbi New colorimetric methods for the determination of trazodone HCl, famotidine, and diltiazem HCl in their pharmaceutical dosage forms
    Magda M Ayad
    Analytical Chemical Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
    Anal Bioanal Chem 376:710-4. 2003
    ..and simple spectrophotometric methods are developed for the determination of trazodone HCl, famotidine, and diltiazem HCl in pure and pharmaceutical preparations...

Research Grants55

  1. Pilot and definitive studies to evaluate Insertional Mutagenesis
    LU TAYLOR; Fiscal Year: 2012
    ..of QT interval prolongation using six drugs (Sotalol, Terfenedine, Bepridil, Loratadine, Lovastatin, and Diltiazem). . If successful, definitive studies will be extended to examine the sensitivity and specificity of the assay...
  2. Studies to Evaluate the Toxicological Potential of Test Articles
    LU TAYLOR; Fiscal Year: 2010
    ..of QT interval prolongation using six drugs (Sotalol, Terfenedine, Bepridil, Loratadine, Lovastatin, and Diltiazem). . If successful, definitive studies will be extended to examine the sensitivity and specificity of the assay...
  3. The Role of Cav1.2 L-type Ca2+ Channels in Cocaine-Induced Reinstatement
    Anjali M Rajadhyaksha; Fiscal Year: 2013
    ..Using the reinstatement of cocaine CPP model, we find that the LTCC antagonist, diltiazem delivered directly into the NAc blocks cocaine-induced reinstatement of cocaine CPP...
  4. CALCIUM AND CONTROL OF RENIN SECRETION
    John Fray; Fiscal Year: 1990
    ..isoproterenol and forskolin, angiotensin II, and ADH, organic Ca-channel blockers (nitrendipine, verapamil, diltiazem, and D-600), and ANP. 2) To study the mode of action of Free Calcium on the renin secretory process...
  5. CALCIUM CHANNEL BLOCKERS--KINETICS, ACTION & METABOLISM
    STEPHEN BAI; Fiscal Year: 1992
    ..The three major agents of this class of drugs are verapamil, nifedipine and diltiazem. The disposition and metabolism of these drugs is not fully clear...
  6. SEROTONIN AND EICOSANOID INTERACTION IN LUNG VASOMOTION
    WENDELL HOFMAN; Fiscal Year: 1992
    ..or receptor-operated channels (ROC) by employing Ca++ channel antagonist specific for either a VOC (verapamil, diltiazem, nitrendipine) or ROC (nitroprusside, nitroglycerin) and VOC patentiators (BAY K 8644)...
  7. EFFECT OF AGING ON CALCIUM BLOCKER KINETICS/DYNAMICS
    JANICE SCHWARTZ; Fiscal Year: 1993
    ..Racemic verapamil elimination is prolonged in healthy elderly while elimination of diltiazem as a single isomer does not differ markedly in elderly vs younger hypertensives...
  8. NOVEL DRUGS TO TREAT URINARY INCONTINENCE
    JAN CHEN; Fiscal Year: 2009
    ..Contrary to other calcium antagonists such as nifedipine and diltiazem, TBDT inhibits bladder contraction but affects neither heart functions nor blood pressure...
  9. PH SENSITIVE COMPLEX HYDROGEL FOR PROTEIN DRUG RELEASE
    NIKOLAOS PEPPAS; Fiscal Year: 2001
    ..Additionally, these gels can be used as carriers of drugs including oxprenolol, proxyphilline, diltiazem and bleomycin, drugs that present a range of ionization characteristics and solubility parameters, The formation ..
  10. OPSIN CGMP-ACTIVATED SINGLE CHANNEL ACTIVITY
    JAMES CLACK; Fiscal Year: 1991
    ..The effect of L-cis-Diltiazem upon channel activity will be studied...
  11. ROLE OF NUCLEUS ACCUMBENS CA2+ FLUX IN COCAINE REWARD
    WILLIAM CARLEZON; Fiscal Year: 2000
    ..25 mg/kg, IP) with intra-NASh microinjections of an L-type Ca2+ channel antagonist (diltiazem) or an activator (BAY k 8644) during drug conditioning sessions...
  12. Function of L-Type Ca2+ Channels in B-Lymphocytes
    Anne Laure Perraud; Fiscal Year: 2009
    ..Statement: L-type Ca2+ channels are important therapeutic targets of a class of drugs that include verapamil and diltiazem, which are commonly used to treat conditions such as hypertension in patients...
  13. REGULATION OF MEMBRANE MEDIATED MUSCLE DEGENERATION
    Syamal Bhattacharya; Fiscal Year: 1992
    ..the mechanism(s) of EICA at the cellular and subcellular levels, and (3) to evaluate the effects of ATP-MgCl2, Diltiazem (DTZM), and their combination in the regulation of EICA in DH...
  14. CALCIUM & CALCIUM ANTAGONISM IN SMOOTH & CARDIAC MUSCLE
    David Triggle; Fiscal Year: 1991
    The Ca2+ channel drugs, including the clinically available verapamil, nifedipine and diltiazem, enjoy prominent use both as therapeutic agents in the control of number of cardiovascular disorders, but also as molecular probes with which ..
  15. RECEPTORS FOR CALCIUM CHANNEL INHIBITORS
    PAL VAGHY; Fiscal Year: 1992
    ..subunit. This is a 1,4- dihydropyridine and phenylalkylamine binding polypeptide. Diltiazem (benzothiazepine) binding to this polypeptide has not been demonstrated...
  16. MECHANISMS OF OCCLUSION IN A STENOSED CORONARY ARTERY
    CLAUDE BENEDICT; Fiscal Year: 1991
    ..Selected agents (aspirin, LY53857, dazoxiben, aminophylline, PGE1, SQ29548, heparin, diltiazem) will be used singly or in combination to inhibit specific mechanisms that lead to platelet aggregation and ..
  17. NEW ASYMMETRIC PROCESSES FOR USE IN ORGANIC SYNTHESIS
    K Sharpless; Fiscal Year: 1999
    ..g. beta-lactams, diltiazem, brassinolide, antibiotic AT-125, cianidanol, etc.)...
  18. CA2 CHANNELS--CHARACTERIZATION OF DRUG BINDING SITES
    MICHAEL PIASCIK; Fiscal Year: 1990
    ..employ a series of calcium entry blockers in the intact rabbit aorta and ligand binding studies with tritiated diltiazem and desmethoxyverapamil in smooth muscle membranes to characterize the different types of drug binding sites ..
  19. Calcium Channel Gating: It Matters How You Splice It.
    William Horne; Fiscal Year: 2006
    ..The alpha1 subunits serve as targets for several classes of therapeutic agents, including antiarrhythmics (diltiazem, L-type antagonist) and analgesics (ziconotide, N-type antagonist from a marine snail), and for a host of ..
  20. Diagnostic and Treatment Strategies for Preclinical HCM
    Carolyn Ho; Fiscal Year: 2009
    ..Second, a pilot interventional trial will be performed to assess the tolerability and efficacy of diltiazem treatment of this preclinical population in improving parameters of diastolic function and to serve as the basis ..
  21. PATHOGENESIS AND PREVENTION OF VALVE CALCIFICATION
    Hiroaki Harasaki; Fiscal Year: 1991
    ..One particular calcium entry blocker, Diltiazem, is proposed to be tested in prevention of calcification in orthotopically implanted bioprosthetic valves in ..
  22. Mechanisms of Cell Death in Cardiomyopathy
    TUAN KUO; Fiscal Year: 2004
    ..Intervention of cardiomyopathy will be carried out by diltiazem treatment, and heart tissue or mitochondria examined for the prevention of lesion development and for the ..
  23. Retinal Oxygenation in Diabetic Retinopathy
    BRUCE BERKOWITZ; Fiscal Year: 2004
    ..The results of these studies could lead to the development of a non-invasive real time method for the early evaluation of diabetic retinopathy and its treatment. ..
  24. Manganese-enhanced MRI Studies of Retinal Neovascularization
    BRUCE BERKOWITZ; Fiscal Year: 2008
    ..The novel methods in this application will also contribute to the advancement of functional MRI for the study of retinal diseases. [unreadable] [unreadable] [unreadable]..
  25. MR STUDIES OF EXPERIMENTAL RETINOPATHY OF PREMATURITY
    BRUCE BERKOWITZ; Fiscal Year: 2001
    ..This work may have broad impact beyond ROP since abnormal blood vessel growth is a common pathobiologic event for other blinding disorders, such as diabetic retinopathy. ..
  26. Conference on Childhood, Culture, and Neurodevelopment
    Mark Barad; Fiscal Year: 2008
    ..abstract_text> ..
  27. Novel GABA Actions on the Developing Brain
    Joseph Nunez; Fiscal Year: 2008
    ..I intend to pursue this research in a laboratory of my own. ..
  28. Chondrocyte S100/Calgranulins and RAGE in Osteoarthritis
    Robert Terkeltaub; Fiscal Year: 2009
    ..Completion of the work will reveal new potential targets for therapeutic intervention in OA by disconnecting inflammation from deleterious alteration of chondrocyte differentiation and function. ..
  29. Genetics of Chronic Kidney Disease
    Stephen T Turner; Fiscal Year: 2010
    ..abstract_text> ..
  30. Low-Level Prenatal Lead Exposure and Retinal Toxicity
    Donald Fox; Fiscal Year: 2009
    ....
  31. Disulfiram for Cocaine Abuse in Metadone - Patients
    Alison Oliveto; Fiscal Year: 2010
    ..The prognostic relevance of other factors (e.g., sex, discounting behavior) will also be examined. ..
  32. Genetics of Microangiopathic Brain Injury
    Stephen T Turner; Fiscal Year: 2010
    ..abstract_text> ..
  33. Opioid Antagonist Discrimination: A Model of Withdrawal
    Alison Oliveto; Fiscal Year: 2011
    ..order to do the following: 1) explore the efficacy of CCBs by testing the proto-typic L-type agents (nifedipine, diltiazem, verapamil) as well as the N-type CCB gabapentin;2) explore the efficacy of D-cycloserine at higher doses and ..
  34. Bioinformatics for Protein Microarrays
    Richard Zangar; Fiscal Year: 2009
    ....
  35. ANK and Joint Ankylosis in Spondylitis
    Robert Terkeltaub; Fiscal Year: 2008
    ..These studies will identify novel targets for enthesopathic bone fusion in spondyloarthritis. ..
  36. Cytokine and MAP Kinase Involvement in Neuropathic Pain
    Linda Sorkin; Fiscal Year: 2008
    ..This approach has the potential for avoiding some of the problems that occur with complete inhibition of p38 function. ..
  37. REGULATION OF XENOBIOTIC-METABOLIZING CYP3A
    Richard Zangar; Fiscal Year: 2002
    ....
  38. HYPOXIA AND ET-1 EFFECT ON PA SMC EFFECT ON CHANNELS
    David Rodman; Fiscal Year: 2002
    ....
  39. BENZODIAZEPINE USE AND RISK OF DISABILITY IN THE ELDERLY
    Shelly Gray; Fiscal Year: 2003
    ....
  40. ADVENTITIAL RESPONSE TO VASCULAR INJURY: ESTROGEN
    Suzanne Oparil; Fiscal Year: 2003
    ..These fundamental mechanistic studies will establish more rational strategies for therapeutic intervention in vascular diseases, including the basis for future gene therapy. ..
  41. DETERMINANTS OF PROCEDURE USE IN MYOCARDIAL INFARCTION
    James Jollis; Fiscal Year: 2003
    ..We will also examine "which rate is right?" by comparing adjusted outcomes (mortality, resource use, and costs), and by comparing procedure use to approaches based on medical evidence. ..
  42. MECHANISMS AND FUNCTIONS OF ASTROCYTE CALCIUM SIGNALING
    Andrew Charles; Fiscal Year: 2004
    ....
  43. Rodent models of anxiety disorder treatment
    Mark Barad; Fiscal Year: 2004
    ..abstract_text> ..
  44. Ca permeable non-NMDAr: New spinal sensitization pathway
    Linda Sorkin; Fiscal Year: 2005
    ..We propose to investigate the effects of Ca-permeable non-NMDAr activation on ERK and CREB phosphorylation (using Western blots and immunohistochemistry), expression of c-fos and development of hyperalgesia. ..
  45. PTHRP 1 to 173 IN CHONDROCYTES
    Robert Terkeltaub; Fiscal Year: 2005
    ..Completion of these studies will indicate not only how PTHrP 1-173 can modulate OA, but also how functional properties of the PTHrP 1-173 C-terminal 140-173 domain can be harnessed to promote cartilage repair. ..
  46. Annual Meeting of the American Pain Society
    Linda Sorkin; Fiscal Year: 2005
    ..Abstracts will be judged on scientific merit and published in The Journal of Pain. We believe that these awards will encourage meeting attendance by trainees. ..
  47. Behavioral Effects of GHB in Healthy Volunteers
    ALISON OLIVETO BEAUDOIN; Fiscal Year: 2003
    ..This study will also potentially establish a standard methodology to characterize systematically the behavioral effects of GHB in humans. ..
  48. GENETIC EPIDEMIOLOGY OF RESPONSES TO ANTIHYPERTENSIVES
    Stephen Turner; Fiscal Year: 2006
    ....
  49. Anthipertensive PharmacoGenomics
    Stephen Turner; Fiscal Year: 2006
    ..abstract_text> ..
  50. Translating Extinction of Fear to Anxiety Disorder Treatment
    Mark Barad; Fiscal Year: 2006
    ..These experiments should help establish the translational validity of the extinction model for anxiety disorder treatment and also may yield potential improvements in current anxiety disorder treatments. ..
  51. Proton as co-transmitter of neuronal signaling
    Martin Morad; Fiscal Year: 2006
    ..abstract_text> ..
  52. Growth Hormone and Rosiglitazone for Visceral Adoposity
    Marshall Glesby; Fiscal Year: 2007
    ..If the results are as predicted, then combination therapy with rhGH and rosiglitazone may prove to be a highly effective treatment for visceral adiposity in HIV-infected patients. ..
  53. Estrogen Modulates Injury-Induced Inflammation
    Suzanne Oparil; Fiscal Year: 2007
    ..These fundamental mechanistic studies will enhance our understanding of the pathobiology of vascular disease, particularly as it occurs in aging women, and will provide the basis for development of novel therapeutic strategies. ..
  54. NOS GENE TRANSFER IN PULMONARY HYPERTENSION
    David Rodman; Fiscal Year: 2002
    ....