Summary: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.

Top Publications

  1. ncbi Comparison of midazolam sedation with or without fentanyl in cataract surgery
    O Yalcin Cok
    Department of Anesthesiology and Reanimation, Baskent University, Faculty of Medicine, Ankara, Turkey
    Acta Anaesthesiol Belg 59:27-32. 2008
  2. ncbi Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial
    Richard R Riker
    University of Vermont College of Medicine, USA
    JAMA 301:489-99. 2009
  3. ncbi Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials
    Stephan M Jakob
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern, Bern, Switzerland
    JAMA 307:1151-60. 2012
  4. pmc Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness
    Fabio Ferrarelli
    Department of Psychiatry and Anesthesiology, University of Wisconsin, Madison, WI 53719, USA
    Proc Natl Acad Sci U S A 107:2681-6. 2010
  5. pmc Pharmacokinetic assessment of a five-probe cocktail for CYPs 1A2, 2C9, 2C19, 2D6 and 3A
    Sandrine Turpault
    Global Metabolism and Pharmacokinetics, Sanofi Aventis, Malvern, PA, USA
    Br J Clin Pharmacol 68:928-35. 2009
  6. ncbi Propofol sedation for upper gastrointestinal endoscopy in patients with liver cirrhosis as an alternative to midazolam to avoid acute deterioration of minimal encephalopathy: a randomized, controlled study
    Andrea Riphaus
    Department of Internal Medicine I, Gastroenterology and Interventional Endoscopy, Hospital Siloah, Hannover, Germany
    Scand J Gastroenterol 44:1244-51. 2009
  7. ncbi Treatment of refractory status epilepticus with pentobarbital, propofol, or midazolam: a systematic review
    Jan Claassen
    Department of Neurology, Division of Critical Care Neurology, and The Comprehensive Epilepsy Center, Neurological Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Epilepsia 43:146-53. 2002
  8. ncbi Pharmacokinetic interactions of almorexant with midazolam and simvastatin, two CYP3A4 model substrates, in healthy male subjects
    Matthias Hoch
    Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123 Allschwil, Switzerland
    Eur J Clin Pharmacol 69:523-32. 2013
  9. ncbi Sub-clinical hepatic encephalopathy in cirrhotic patients is not aggravated by sedation with propofol compared to midazolam: a randomized controlled study
    Iyad Khamaysi
    Department of Gastroenterology, Rambam Medical Center, Haifa, Israel
    J Hepatol 54:72-7. 2011
  10. ncbi Stochastic prediction of CYP3A-mediated inhibition of midazolam clearance by ketoconazole
    Jenny Y Chien
    Department of Drug Disposition, Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Drug Metab Dispos 34:1208-19. 2006

Detail Information

Publications357 found, 100 shown here

  1. ncbi Comparison of midazolam sedation with or without fentanyl in cataract surgery
    O Yalcin Cok
    Department of Anesthesiology and Reanimation, Baskent University, Faculty of Medicine, Ankara, Turkey
    Acta Anaesthesiol Belg 59:27-32. 2008
    We compared the effect of midazolam sedation with or without fentanyl on the hemodynamic parameters, sedation, and pain and satisfaction profile in cataract surgery...
  2. ncbi Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial
    Richard R Riker
    University of Vermont College of Medicine, USA
    JAMA 301:489-99. 2009
    ..Gamma-aminobutyric acid receptor agonist medications are the most commonly used sedatives for intensive care unit (ICU) patients, yet preliminary evidence indicates that the alpha(2) agonist dexmedetomidine may have distinct advantages...
  3. ncbi Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials
    Stephan M Jakob
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern, Bern, Switzerland
    JAMA 307:1151-60. 2012
    Long-term sedation with midazolam or propofol in intensive care units (ICUs) has serious adverse effects...
  4. pmc Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness
    Fabio Ferrarelli
    Department of Psychiatry and Anesthesiology, University of Wisconsin, Madison, WI 53719, USA
    Proc Natl Acad Sci U S A 107:2681-6. 2010
    ..this hypothesis by comparing EEG responses to TMS during wakefulness and LOC induced by the benzodiazepine midazolam. Unlike spontaneous sleep states, a subject's level of vigilance can be monitored repeatedly during ..
  5. pmc Pharmacokinetic assessment of a five-probe cocktail for CYPs 1A2, 2C9, 2C19, 2D6 and 3A
    Sandrine Turpault
    Global Metabolism and Pharmacokinetics, Sanofi Aventis, Malvern, PA, USA
    Br J Clin Pharmacol 68:928-35. 2009
  6. ncbi Propofol sedation for upper gastrointestinal endoscopy in patients with liver cirrhosis as an alternative to midazolam to avoid acute deterioration of minimal encephalopathy: a randomized, controlled study
    Andrea Riphaus
    Department of Internal Medicine I, Gastroenterology and Interventional Endoscopy, Hospital Siloah, Hannover, Germany
    Scand J Gastroenterol 44:1244-51. 2009
    b>Midazolam sedation for upper gastrointestinal (GI) endoscopy exacerbates minimal hepatic encephalopathy (HE) in patients with liver cirrhosis, therefore an alternative drug regimen for these patients is warranted...
  7. ncbi Treatment of refractory status epilepticus with pentobarbital, propofol, or midazolam: a systematic review
    Jan Claassen
    Department of Neurology, Division of Critical Care Neurology, and The Comprehensive Epilepsy Center, Neurological Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Epilepsia 43:146-53. 2002
    ..This systematic review compares the efficacy of midazolam (MDL), propofol (PRO), and pentobarbital (PTB) for terminating seizures and improving outcome in RSE patients.
  8. ncbi Pharmacokinetic interactions of almorexant with midazolam and simvastatin, two CYP3A4 model substrates, in healthy male subjects
    Matthias Hoch
    Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123 Allschwil, Switzerland
    Eur J Clin Pharmacol 69:523-32. 2013
    ..Therefore, a study was conducted to investigate the effects of multiple-dose almorexant on the pharmacokinetics of midazolam and simvastatin, two CYP3A4 model substrates.
  9. ncbi Sub-clinical hepatic encephalopathy in cirrhotic patients is not aggravated by sedation with propofol compared to midazolam: a randomized controlled study
    Iyad Khamaysi
    Department of Gastroenterology, Rambam Medical Center, Haifa, Israel
    J Hepatol 54:72-7. 2011
    ..The aim of this study is to determine whether the use of propofol, for upper endoscopy in patients with cirrhosis, precipitates sub-clinical HE...
  10. ncbi Stochastic prediction of CYP3A-mediated inhibition of midazolam clearance by ketoconazole
    Jenny Y Chien
    Department of Drug Disposition, Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Drug Metab Dispos 34:1208-19. 2006
    ..A physiologically based PK model was developed to predict the inhibition of CYP3A by ketoconazole (KTZ), using midazolam (MDZ) as the substrate...
  11. ncbi Clinically relevant concentrations of propofol but not midazolam alter in vitro dendritic development of isolated gamma-aminobutyric acid-positive interneurons
    Laszlo Vutskits
    Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University Hospital of Geneva, Switzerland
    Anesthesiology 102:970-6. 2005
    ..The authors addressed this issue by evaluating the effect of propofol on dendritic growth and arbor expansion of developing gamma-aminobutyric acid-positive (GABAergic) interneurons...
  12. ncbi Propofol infusion versus intermittent meperidine and midazolam injection for conscious sedation in ERCP
    Pradermchai Kongkam
    Division of Gastroenterology, Department of Internal Medicine, Chulalongkorn University, Bangkok, Thailand
    J Gastrointestin Liver Dis 17:291-7. 2008
    ..This study was conducted to compare satisfaction, recovery score, and recovery/safety profiles for ERCP sedation between continuous infusion of propofol and conventional sedation...
  13. ncbi Intrathecal midazolam I: a cohort study investigating safety
    Adam P Tucker
    Department of Anaesthesia, Monash Medical Centre, Monash University, 246 Clayton Road, Victoria 3168, Australia
    Anesth Analg 98:1512-20, table of contents. 2004
    Despite conflicting evidence regarding the safety of intrathecal midazolam from animal investigations, its clinical use is increasing...
  14. ncbi Long-term sedation in intensive care unit: a randomized comparison between inhaled sevoflurane and intravenous propofol or midazolam
    Malcie Mesnil
    Department of Anesthesiology and Critical Care Lapeyronie DAR A, Montpellier I University and Montpellier University Lapeyronie Hospital, Institut National de la Sante et de la Recherche Medicale INSERM, Equipe soutenue par la Région et l Inserm ERI 25, route de Ganges, 34295 Montpellier, Cedex 5, France
    Intensive Care Med 37:933-41. 2011
    To evaluate efficacy and adverse events related to inhaled sevoflurane for long-term sedation compared with standard intravenous (i.v.) sedation with propofol or midazolam.
  15. ncbi Intranasal midazolam for prolonged convulsive seizures
    N O Kutlu
    Department of Pediatrics, Inonu University, Turgut Ozal Medical Center, Malatya, Turkey
    Brain Dev 22:359-61. 2000
    In order to determine the efficiency of intranasal midazolam in prolonged convulsive episodes, we conducted a prospective study in children with various types of seizures...
  16. ncbi Intranasal midazolam vs rectal diazepam for the home treatment of acute seizures in pediatric patients with epilepsy
    Maija Holsti
    Department of Pediatrics, University of Utah, 295 Chipeta Way, Salt Lake City, UT 84108, USA
    Arch Pediatr Adolesc Med 164:747-53. 2010
    To compare intranasal midazolam, using a Mucosal Atomization Device (IN-MMAD), with rectal diazepam (RD) for the home treatment of seizures in children with epilepsy.
  17. ncbi Use of intrathecal midazolam to improve perioperative analgesia: a meta-analysis
    K M Ho
    Intensive Care Unit, Royal Perth Hospital, Perth, Western Australia, Australia
    Anaesth Intensive Care 36:365-73. 2008
    Intrathecal midazolam binds with gamma aminobutyric acid-A receptors in the spinal cord leading to an analgesic effect...
  18. ncbi Analgesic efficacy of two doses of intrathecal midazolam with bupivacaine in patients undergoing cesarean delivery
    Smita Prakash
    Department of Anesthesia and Intensive Care, Vardhman Mahavir Medical College and Safdarjang Hospital, New Delhi, India
    Reg Anesth Pain Med 31:221-6. 2006
    In this prospective, randomized, double-blind, placebo-controlled study, we investigated the postoperative analgesic efficacy of 2 doses of intrathecal midazolam as an adjunct to bupivacaine for spinal anesthesia.
  19. ncbi Efficacy of buccal midazolam compared to intravenous diazepam in controlling convulsions in children: a randomized controlled trial
    Bibek Talukdar
    Department of Pediatrics, Maulana Azad Medical College and Asssociated Chacha Nehru Bal Chikitsalaya CNBC, Delhi 110031, India
    Brain Dev 31:744-9. 2009
    A study was done to examine the efficacy of buccal midazolam in controlling convulsion in children by comparing it with intravenous diazepam, a standard mode of treating convulsions...
  20. ncbi Disruptive effect of midazolam on fear memory reconsolidation: decisive influence of reactivation time span and memory age
    Silvia G Bustos
    Departamento de Farmacologia, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Haya de la Torre y Medina Allende, Cordoba, Argentina
    Neuropsychopharmacology 34:446-57. 2009
    ..memory was reactivated by exposure to the associated context for different periods of time that were followed by midazolam (MDZ) administration. We also studied MDZ amnesic effect after reactivating fear memories of several ages...
  21. ncbi Preoperative intravenous midazolam: benefits beyond anxiolysis
    Kevin P Bauer
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Clin Anesth 16:177-83. 2004
    To evaluate the effect of midazolam on the global perioperative experience, including patient satisfaction, postoperative nausea and vomiting, postoperative pain, and perioperative anxiety and amnesia.
  22. ncbi Intrathecal midazolam increases the analgesic effects of spinal blockade with bupivacaine in patients undergoing haemorrhoidectomy
    M H Kim
    Department of Anaesthesiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Br J Anaesth 86:77-9. 2001
    In the present double-blind study we aimed to evaluate the postoperative analgesic effects of intrathecal midazolam with bupivacaine following haemorrhoidectomy...
  23. ncbi Propofol alone titrated to deep sedation versus propofol in combination with opioids and/or benzodiazepines and titrated to moderate sedation for colonoscopy
    Megan E VanNatta
    Department of Medicine, Division of Gastroenterology, Indiana University School of Medicine, Indianapolis Indiana 46202, USA
    Am J Gastroenterol 101:2209-17. 2006
    ..Propofol in combination with opioids and/or benzodiazepines can be titrated to moderate sedation, which might be safer...
  24. ncbi Midazolam vs ondansetron for preventing postoperative nausea and vomiting: a randomised controlled trial
    Y Lee
    Buddhist Tzu Chi Medical Center, Tzu Chi University School of Medicine, No 707 Sec 3 Jhong Yang Rd, Hualien, Taiwan, ROC
    Anaesthesia 62:18-22. 2007
    We compared the prophylactic anti-emetic efficacy of midazolam and ondansetron in 90 patients scheduled for minor gynaecological (hysteroscopy) or urological (ureteroscopy) procedures planned to last 1-2 h under sevoflurane anaesthesia ..
  25. ncbi Midazolam reverses salicylate-induced changes in brain-derived neurotrophic factor and arg3.1 expression: implications for tinnitus perception and auditory plasticity
    Rama Panford-Walsh
    Department of Otorhinolaryngology, Universitat Tubingen, Tubingen, Germany
    Mol Pharmacol 74:595-604. 2008
    ..Local application of the GABA(A) receptor modulator midazolam resulted in the reversal not only of salicylate-induced changes in cochlear BDNF expression, but also in ..
  26. ncbi Comparison of the cardiorespiratory effects of medetomidine-butorphanol-ketamine and medetomidine-butorphanol-midazolam in patas monkeys (Erythrocebus patas)
    Gladys Kalema-Zikusoka
    Environmental Medicine Consortium, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
    J Zoo Wildl Med 34:47-52. 2003
    ..0 mg/kg. i.m.), and seven were injected with the same dosages of medetomidine and butorphanol plus midazolam (0.3 mg/kg, i.m.)...
  27. ncbi Effect of telaprevir on the pharmacokinetics of midazolam and digoxin
    Varun Garg
    Vertex Pharmaceuticals Incorporated, Cambridge, MA 02139 4242, USA
    J Clin Pharmacol 52:1566-73. 2012
    In this open-label study, 24 healthy volunteers received a single intravenous (IV) dose of 0.5 mg of midazolam on day 1 and a single oral dose each of 2 mg of midazolam and 0.5 mg of digoxin on day 3...
  28. pmc ESRD impairs nonrenal clearance of fexofenadine but not midazolam
    Thomas D Nolin
    Department of Pharmacy and Therapeutics, and Center for Clinical Pharmaceutical Research, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania 15261, USA
    J Am Soc Nephrol 20:2269-76. 2009
    ..We used midazolam and fexofenadine to assess CYP3A (intestinal and hepatic) and drug transport, respectively, in patients with ..
  29. ncbi The different effects of midazolam and propofol sedation on dynamic cerebral autoregulation
    Yojiro Ogawa
    Department of Social Medicine, Division of Hygiene, Nihon University School of Medicine, Tokyo, Japan
    Anesth Analg 111:1279-84. 2010
    Although midazolam and propofol reduce cerebral blood flow (CBF) similarly, they generate different effects on the autonomic nervous system and endothelium-induced relaxation...
  30. ncbi Adaptive time-frequency parametrization in pharmaco EEG
    Piotr J Durka
    Laboratory of Medical Physics, Institute of Experimental Physics, Warsaw University, ul Hoza 69, 00 681 Warszawa, Poland
    J Neurosci Methods 117:65-71. 2002
    ..These advantages are illustrated using a double-blind test of the influence of zolpidem and midazolam on sleep EEG, and the results are compared with the traditional approach...
  31. ncbi Supraspinal anesthesia: behavioral and electroencephalographic effects of intracerebroventricularly infused pentobarbital, propofol, fentanyl, and midazolam
    Izabela Jugovac
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Anesthesiology 105:764-78. 2006
    ..The authors aimed to produce progressively increasing anesthetic depths, indicated by electro-encephalographic synchronization and behavioral change...
  32. pmc The impact of a standardised intramuscular sedation protocol for acute behavioural disturbance in the emergency department
    Leonie A Calver
    Discipline of Clinical Pharmacology, University of Newcastle, New South Wales, Australia
    BMC Emerg Med 10:14. 2010
    ..Acute behavioural disturbance (ABD) is an increasing problem in emergency departments. This study aimed to determine the impact of a structured intramuscular (IM) sedation protocol on the duration of ABD in the emergency department...
  33. ncbi Dexmedetomidine versus midazolam for the sedation of patients with non-invasive ventilation failure
    Zhao Huang
    Department of Intensive Care Unit, Guangzhou First Municipal People s Hospital Affiliated to Guangzhou Medical College, PR China
    Intern Med 51:2299-305. 2012
    To compare the efficacy and safety of sedation with dexmedetomidine vs. midazolam for patients with acute cardiogenic pulmonary edema and hypoxemia during the treatment of non-invasive ventilation (NIV).
  34. ncbi Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study
    Peter V Sackey
    Section of Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm, Sweden
    Crit Care Med 36:801-6. 2008
    To compare memories from the intensive care unit (ICU) and short- and long-term psychological morbidity in patients after sedation with intravenous midazolam or inhaled isoflurane.
  35. ncbi Evaluation of butorphanol, medetomidine and midazolam as a reversible narcotic combination in free-ranging African lions (Panthera leo)
    Sandra Wenger
    Clinic for Zoo Animals, Exotic Pets and Wildlife, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    Vet Anaesth Analg 37:491-500. 2010
    To evaluate the effects of the combination butorphanol, medetomidine and midazolam (BMM) and its reversibility in lions.
  36. pmc Anesthetic effects of a mixture of medetomidine, midazolam and butorphanol in two strains of mice
    Yumiko Kirihara
    Department of Experimental Animals, Center for Integrated Research in Science, Shimane University, 89 1 Enya cho, Izumo, Shimane 693 8501, Japan
    Exp Anim 62:173-80. 2013
    ..These results indicate that the mixture of Med., Mid., and But. can be a useful and effective anesthesia for the BALB/c and C57BL/6J strains of inbred mice as well as outbred ICR mice. ..
  37. ncbi Nurse-administered propofol versus midazolam and meperidine for upper endoscopy in cirrhotic patients
    Brian R Weston
    Division of Gastroenterology and Hepatology, Indiana University Medical Center, Indianapolis, Indiana 46202, USA
    Am J Gastroenterol 98:2440-7. 2003
    ..Propofol is currently under evaluation as an alternative to the combination of midazolam and meperidine for sedation during endoscopic procedures...
  38. ncbi Effects of aprepitant on cytochrome P450 3A4 activity using midazolam as a probe
    Anup K Majumdar
    Merck Research Laboratories, West Point, PA 19422, USA
    Clin Pharmacol Ther 74:150-6. 2003
    ..The effect of aprepitant on in vivo CYP3A4 activity in humans with oral midazolam used as a sensitive probe of CYP3A4 activity was evaluated in this study.
  39. ncbi Defective activity of recombinant cytochromes P450 3A4.2 and 3A4.16 in oxidation of midazolam, nifedipine, and testosterone
    Mitsue Miyazaki
    Department of Clinical Pharmacology, Gunma University Graduate School of Medicine, Showa machi 3 39 22, Maebashi 371 8511, Gunma, Japan
    Drug Metab Dispos 36:2287-91. 2008
    ..b>Midazolam (MDZ), testosterone (TST), and nifedipine (NIF) were used to assess the catalytic activities of the CYP3A4 wild ..
  40. ncbi Oral melatonin, dexmedetomidine, and midazolam for prevention of postoperative agitation in children
    Dilek Ozcengiz
    Department of Anesthesiology, Medical Faculty, Cukurova University, Balcali, Adana, Turkey
    J Anesth 25:184-8. 2011
    ..The aim of this study was to compare early agitation characteristics of oral melatonin, dexmedetomidine, and midazolam premedication in children who were given sevoflurane anesthesia for esophageal dilatation.
  41. ncbi Adverse events during monitored anesthesia care for GI endoscopy: an 8-year experience
    Massimo Agostoni
    Department of Anesthesiology, Vita Salute University of Milan, IRCCS H San Raffaele, Milan, Italy
    Gastrointest Endosc 74:266-75. 2011
    ..The importance of sedation during endoscopy is well established. There is no consensus about the best techniques for sedation, which specialist should perform it, and in which location...
  42. ncbi Sorafenib and sunitinib, two anticancer drugs, inhibit CYP3A4-mediated and activate CY3A5-mediated midazolam 1'-hydroxylation
    Minako Sugiyama
    Department of Medical Oncology, International Medical Center Comprehensive Cancer Center, Saitama Medical University, Hidaka, Japan
    Drug Metab Dispos 39:757-62. 2011
    ..The effects of sorafenib and sunitinib on midazolam 1'-hydroxylation catalyzed by human CYP3A4 or CYP3A5 were investigated...
  43. ncbi Pharmacokinetics of oral dexamethasone and midazolam when administered with single-dose intravenous 150 mg fosaprepitant in healthy adult subjects
    Thomas C Marbury
    Orlando Clinical Research Center, Orlando, FL 32809, USA
    J Clin Pharmacol 51:1712-20. 2011
    ..Part 2 of the study evaluated the drug interaction between fosaprepitant 150 mg and oral midazolam (2 mg on days 1 and 4). Thirteen subjects were enrolled in part 1 and 10 in part 2...
  44. ncbi A comparison of midazolam nasal spray and diazepam rectal solution for the residential treatment of seizure exacerbations
    Gerrit Jan de Haan
    SEIN Epilepsy Institute in The Netherlands Foundation Heemstede, The Netherlands
    Epilepsia 51:478-82. 2010
    ..if an alternative route of administration of a benzodiazepine was equally effective, we compared a novel midazolam HCl concentrated nasal spray (MDZ-n) with diazepam rectal solution (DZP-r) in the treatment of prolonged ..
  45. pmc Midazolam versus diazepam for the treatment of status epilepticus in children and young adults: a meta-analysis
    Jason McMullan
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA
    Acad Emerg Med 17:575-82. 2010
    Rapid treatment of status epilepticus (SE) is associated with better outcomes. Diazepam and midazolam are commonly used, but the optimal agent and administration route is unclear.
  46. ncbi Induction of anaesthesia with either midazolam or propofol in rabbits premedicated with fentanyl/fluanisone
    M A Martinez
    Department of Clinical Veterinary Science, University of Bristol, Langford
    Vet Rec 164:803-6. 2009
    ..1 ml/kg fentanyl/fluanisone and then randomly allocated to be anaesthetised with either midazolam or propofol. Anaesthesia was then maintained with isoflurane...
  47. ncbi A simplified analytical method for a phenotyping cocktail of major CYP450 biotransformation routes
    Mallorie Clement Jerdi
    Clinical Pharmacology and Toxicology, Geneva University Hospitals, 24, Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    J Pharm Biomed Anal 35:1203-12. 2004
    ..approach including five probe substances, namely caffeine, flurbiprofen, omeprazole, dextromethorphan and midazolam. All substances were administered simultaneously and a single plasma sample was obtained 2h after the ..
  48. ncbi Remifentanil vs. meperidine for patient-controlled analgesia during colonoscopy: a randomized double-blind trial
    Lorella Fanti
    Department of Gastroenterology, Vita Salute University of Milano, IRCCS H San Raffaele, Milano, Italy
    Am J Gastroenterol 104:1119-24. 2009
    The aim was to compare patients' and endoscopists' satisfaction in terms of efficacy and safety of remifentanil patient-controlled analgesia (PCA) during colonoscopy with that of a combination of midazolam and meperidine.
  49. ncbi Intranasal midazolam vs rectal diazepam in acute childhood seizures
    Madhumita Bhattacharyya
    Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Pediatr Neurol 34:355-9. 2006
    ..seizure episodes in 46 children were randomly assigned to receive treatment with rectal diazepam and intranasal midazolam with doses of 0.3 mg/kg body weight and 0.2 mg/kg body weight, respectively...
  50. ncbi Gastroenterologist-administered propofol versus meperidine and midazolam for advanced upper endoscopy: a prospective, randomized trial
    John J Vargo
    Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Gastroenterology 123:8-16. 2002
    ..has been no prospective, randomized comparison of gastroenterologist-administered propofol to meperidine and midazolam for endoscopic retrograde cholangiopancreatography and endoscopic ultrasonography...
  51. ncbi Effects of intrathecal midazolam in spinal anaesthesia: a prospective randomised case control study
    B K Shadangi
    Department of Anaesthesiology, All India Institute of Medical Scences, Ansari Nagar, New Delhi 110029, India
    Singapore Med J 52:432-5. 2011
    Subarachnoid block with local anaesthetics and adjuvants has been extensively used for surgery. Intrathecal midazolam produces antinociception and potentiates the effect of local anaesthetics...
  52. ncbi Genotype-phenotype associations of cytochrome P450 3A4 and 3A5 polymorphism with midazolam clearance in vivo
    Ping He
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    Clin Pharmacol Ther 77:373-87. 2005
    ..A single oral dose of midazolam was administered to 26 healthy subjects. The variability in midazolam oral clearance was 11-fold...
  53. pmc Ketamine and midazolam sedation for pediatric gastrointestinal endoscopy in the Arab world
    Mohamad Iqbal S Miqdady
    Pediatric Department, Medical School, Jordan University of Science and Technology, Irbid 3030, Jordan
    World J Gastroenterol 17:3630-5. 2011
    To evaluate the safety and effectiveness of intravenous ketamine-midazolam sedation during pediatric endoscopy in the Arab world.
  54. ncbi Effect of intravenous midazolam premedication on postoperative nausea and vomiting after cholecystectomy
    Seied Morteza Heidari
    Department of Anesthesia, Isfahan University of Medical Sciences, Isfahan, Iran
    Acta Anaesthesiol Taiwan 42:77-80. 2004
    ..However PONV continues to be a common postoperative complication. Midazolam premedication in pediatric patients has been reported to reduce the incidence of PONV...
  55. ncbi The analgesic and sedative effects of intrathecal midazolam in perianal surgery
    A Yegin
    Akdeniz University Medical Faculty, Department of Anaesthesiology, Antalya, Turkey
    Eur J Anaesthesiol 21:658-62. 2004
    Our purpose was to evaluate the analgesic and sedative effects of intrathecal midazolam when added to spinal bupivacaine in patients undergoing perianal surgery under spinal anaesthesia.
  56. ncbi Low dose intravenous midazolam for prevention of PONV, in lower abdominal surgery--preoperative vs intraoperative administration
    Mohammad Reza Safavi
    Department of Anesthesiology and Intensive Care Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
    Middle East J Anaesthesiol 20:75-81. 2009
    The aim of the present study was to compare anti-emetic efficacy of low dose midazolam premedication (35 microg/kg) 15 minutes before induction of anesthesia with midazolam (35 microg/kg) administered intravenously 30 min before ..
  57. ncbi Analgesic effects of systemic midazolam: comparison with intrathecal administration
    Tomoki Nishiyama
    Department of Anesthesiology, The Univesity of Tokyo, Japan
    Can J Anaesth 53:1004-9. 2006
    b>Midazolam has antinociceptive effects when administered intrathecally, while its effects associated with systemic administration remain controversial...
  58. ncbi The midazolam-induced paradox phenomenon is reversible by flumazenil. Epidemiology, patient characteristics and review of the literature
    A A Weinbroum
    Post Anesthesia Care Unit, Tel Aviv Sourasky Medical Center, 6 Weizman St, Tel Aviv 64239, Israel
    Eur J Anaesthesiol 18:789-97. 2001
    b>Midazolam may occasionally precipitate hostility and violence instead of tranquility...
  59. ncbi Deep sedation occurs frequently during elective endoscopy with meperidine and midazolam
    Sandeep Patel
    Section of Endoscopy, Department of Gastroenterology and Hepatology, The Cleveland Clinic Foundation, Cleveland, Ohio 44118, USA
    Am J Gastroenterol 100:2689-95. 2005
    ..The aims of this study were to prospectively evaluate the incidence and risk factors of deep sedation during elective endoscopy with meperidine and midazolam intended to maintain a level of moderate sedation.
  60. ncbi Use of intranasal midazolam to treat acute seizures in paediatric community settings
    M G Harbord
    Department of Paediatrics and Child Health, Flinders Medical Centre, Adelaide, South Australia 5042, Australia
    J Paediatr Child Health 40:556-8. 2004
    To evaluate the acceptability of intranasal midazolam (INM) in acute seizure management in the community.
  61. ncbi Midazolam: an effective antiemetic after cardiac surgery--a clinical trial
    Orathy Patangi Sanjay
    DNB, Department of Anesthesiology, St John s Medical College Hospital, Bangalore 560034, Karnataka, India
    Anesth Analg 99:339-43, table of contents. 2004
    ..To assess the antiemetic property of midazolam, we undertook this double-blinded, randomized trial in 200 patients undergoing cardiac surgery involving ..
  62. pmc Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest
    Philip E Empey
    Department of Pharmacy and Therapeutics, School of Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 40:1221-8. 2012
    ..objectives were to determine the effect of mild hypothermia on the in vivo pharmacokinetics of fentanyl and midazolam, two clinically relevant cytochrome P450 3A substrates, after cardiac arrest and to investigate the mechanisms ..
  63. ncbi Intranasal midazolam therapy for pediatric status epilepticus
    Timothy R Wolfe
    Department of Emergency Medicine, Jordan Valley Hospital, West Jordan, UT 84088, USA
    Am J Emerg Med 24:343-6. 2006
    ..Intranasal midazolam, which delivers antiepileptic medication directly to the blood and cerebrospinal fluid via the nasal mucosa, is ..
  64. ncbi Comparison of propofol/fentanyl versus ketamine/midazolam for brief orthopedic procedural sedation in a pediatric emergency department
    Sandip A Godambe
    Division of Pediatric Emergency Medicine, LeBonheur Children s Medical Center, Memphis, Tennessee, USA
    Pediatrics 112:116-23. 2003
    To compare the effectiveness of 2 medication regimens, propofol/fentanyl (P/F) and ketamine/midazolam (K/M), for brief orthopedic emergency department procedural sedation...
  65. ncbi Prehospital intranasal midazolam for the treatment of pediatric seizures
    Maija Holsti
    Division of Pediatric Emergency Medicine, Department of Pediatrics, Primary Children s Medical Center University of Utah, Salt Lake City, UT 84158, USA
    Pediatr Emerg Care 23:148-53. 2007
    The local emergency medical services (EMS) council implemented a new pediatric treatment protocol using a Mucosal Atomization Device (MAD) to deliver intranasal (IN) midazolam for seizure activity.
  66. pmc Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis
    Kazuhiro Tokuda
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:16788-95. 2010
    ..In rat hippocampal slices, we compared midazolam, an anesthetic BDZ, with clonazepam, an anticonvulsant/anxiolytic BDZ that activates CBRs selectively...
  67. ncbi Safe and effective sedation in endoscopic submucosal dissection for early gastric cancer: a randomized comparison between propofol continuous infusion and intermittent midazolam injection
    Shinsuke Kiriyama
    Department of Endoscopy, National Cancer Center Hospital, Tokyo, Japan
    J Gastroenterol 45:831-7. 2010
    ..The aim of this study was to compare the safety profiles and recovery scores propofol continuous infusion and intermittent midazolam (MDZ) injection as sedation for ESD.
  68. pmc The efficacy of the COMFORT scale in assessing optimal sedation in critically ill children requiring mechanical ventilation
    Hyun Seung Jin
    Department of Pediatrics, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea
    J Korean Med Sci 22:693-7. 2007
    ..7 cases). The total duration of sedation (8.0 days vs. 11.5 days) also tended to decrease. These findings suggest that application of protocol-based sedation with the COMPORT scale may benefit children requiring mechanical ventilation...
  69. ncbi The effects of the SLCO2B1 c.1457C > T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans
    Junko Imanaga
    Department of Clinical Pharmacology and Therapeutics, Oita University Faculty of Medicine, Oita, Japan
    Pharmacogenet Genomics 21:84-93. 2011
    The objective was to determine the effects of the SLCO2B1 c.1457C> T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans.
  70. ncbi Intrathecal midazolam added to bupivacaine improves the duration and quality of spinal anaesthesia
    N Bharti
    Department of Anaesthesiology and Intensive Care, All India Institute of Medical Sciences, New Delhi, India
    Acta Anaesthesiol Scand 47:1101-5. 2003
    The antinociceptive action of intrathecal midazolam is well documented. In this prospective study, we investigated the addition of midazolam to intrathecal bupivacaine on the duration and quality of spinal blockade.
  71. ncbi Reemergence of stroke deficits with midazolam challenge
    Ronald M Lazar
    Department of Neurology, Columbia University College of Physicians and Surgeons, Columbia Presbyterian Medical Center, New York, NY, USA
    Stroke 33:283-5. 2002
    ..a step toward assessing whether neurotransmitter systems underlie poststroke clinical improvement, we selected midazolam, a gamma-aminobutyric acid(A) (GABA(A)) agonist, for systemic administration to measure general or stroke-..
  72. ncbi Nasal midazolam effects on childhood acute seizures
    T Fisgin
    Department of Pediatric Hematology, Dr Sami Ulus Child Health and Disease Center, Ankara, Turkey
    J Child Neurol 15:833-5. 2000
    ..Sami Ulus Child Health and Disease Center, were included in this study. Midazolam (5 mg/mL) 0.2 mg/kg was administered intranasally in 30 seconds by an injector...
  73. ncbi Is intranasal midazolam an effective rescue medication in adolescents and adults with severe epilepsy?
    M Scheepers
    Heathfield, 30 Denmark Road, Gloucester, GL1 3HZ, UK
    Seizure 9:417-22. 2000
    The aim of this study was to determine whether intranasal midazolam is a safe and effective rescue medication in adolescent and adult patients with severe epilepsy...
  74. ncbi Early cognitive impairment after sedation for colonoscopy: the effect of adding midazolam and/or fentanyl to propofol
    Usha Padmanabhan
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia
    Anesth Analg 109:1448-55. 2009
    ..We sought to determine if the use of propofol alone results in less cognitive impairment at discharge than the use of propofol plus midazolam and/or fentanyl in patients presenting for elective outpatient colonoscopy.
  75. ncbi Functional magnetic resonance imaging (fMRI) in children sedated with propofol or midazolam
    Marco Gemma
    Anesthesia and Intensive Care Unit, Head and Neck Department, Vita Salute University, San Raffaele Scientific Institute, Milan, Italy
    J Neurosurg Anesthesiol 21:253-8. 2009
    ..This study compares the effect of propofol and midazolam on the fMRI auditory activation pattern in children...
  76. ncbi Olfactory fear conditioning paradigm in rats: effects of midazolam, propranolol or scopolamine
    Juliana A V Kroon
    Departamento de Farmacologia, CCB, Universidade Federal de Santa Catarina, Florianopolis, SC 88040 900, Brazil
    Neurobiol Learn Mem 91:32-40. 2009
    ..the study of fear-induced behavior and whether compounds used in humans for emotional-related disorders such as midazolam, propranolol, or scopolamine, applied during the different stages of fear conditioning (acquisition, ..
  77. ncbi Comparative study of the antiemetic efficacy of ondansetron, propofol and midazolam in the early postoperative period
    H Unlugenc
    Cukurova University, Faculty of Medicine, Department of Anaesthesiology, Adana, Turkey
    Eur J Anaesthesiol 20:668-73. 2003
    To compare the antiemetic efficacy of ondansetron with two different hypnotic drugs (propofol 15 mg, midazolam 1 and 2 mg) for the treatment of established postoperative nausea and vomiting (PONV).
  78. ncbi Cerebral microdialysis effects of propofol versus midazolam in severe traumatic brain injury
    Michèle Tanguy
    Département d anesthésie réanimation 1, Hopital de Pontchaillou, Cedex, France
    J Neurotrauma 29:1105-10. 2012
    ..The objective was to compare the effects of propofol to midazolam on cerebral biomarkers at the acute phase of severe TBI patients...
  79. ncbi Anticonvulsant treatment of sarin-induced seizures with nasal midazolam: an electrographic, behavioral, and histological study in freely moving rats
    E Gilat
    Department of Pharmacology, Israel Institute for Biological Research, Ness Ziona, 74100 Israel
    Toxicol Appl Pharmacol 209:74-85. 2005
    ..Effective management of these seizures is critical for minimization of brain damage. Nasal application of midazolam (1...
  80. ncbi Ritonavir greatly impairs CYP3A activity in HIV infection with chronic viral hepatitis
    Tamsin A Knox
    Nutrition Infection Division, Department of Public Health and Family Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
    J Acquir Immune Defic Syndr 49:358-68. 2008
    ..Ritonavir is a powerful inhibitor of cytochrome P450 3A (CYP3A) that metabolizes many antiretrovirals. We examined the effect of ritonavir and of chronic viral hepatitis (CVH) status on CYP3A activity...
  81. ncbi Sedation for endoscopy: the safe use of propofol by general practitioner sedationists
    Anthony C Clarke
    Mugga Wara and Brindabella Endoscopy Centres, Canberra, ACT
    Med J Aust 176:158-61. 2002
    ..To determine the incidence of adverse events related to an endoscopy sedation regimen that included propofol, delivered by general practitioner (GP) sedationists...
  82. ncbi Comparison of intranasal midazolam with intravenous diazepam for treating acute seizures in children
    T Mahmoudian
    Department of Child Neurology, Medical University of Isfahan, Isfahan, Iran
    Epilepsy Behav 5:253-5. 2004
    b>Midazolam, a water-soluble benzodiazepine, is usually given intravenously in status epilepticus...
  83. ncbi Patient-controlled analgesia and sedation with alfentanyl versus fentanyl for colonoscopy: a randomized double blind study
    Burhanettin Usta
    Department of Anesthesiology, Fatih University School of Medicine, Ankara, Turkey
    J Clin Gastroenterol 45:e72-5. 2011
  84. ncbi Does midazolam alter the clinical effects of intravenous ketamine sedation in children? A double-blind, randomized, controlled, emergency department trial
    J E Wathen
    Department of Pediatrics, Section of Emergency Medicine, University of Colorado Health Sciences Center The Children s Hospital, Denver, CO, USA
    Ann Emerg Med 36:579-88. 2000
    ..conducted to investigate the frequency and severity of adverse effects, specifically emergence phenomena, experienced by patients receiving intravenous ketamine with or without midazolam for sedation in a pediatric emergency department.
  85. ncbi Oral ketamine/midazolam is superior to intramuscular meperidine, promethazine, and chlorpromazine for pediatric cardiac catheterization
    S M Auden
    Departments of Anesthesiology, Pediatrics, and Family and Community Medicine of the University of Louisville and Kosair Children s Hospital, Louisville, KY 40202, USA
    Anesth Analg 90:299-305. 2000
    ..We compared this IM combination to oral (PO) ketamine/midazolam in children having cardiac catheterization...
  86. ncbi Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study
    M F Hebert
    Department of Pharmacy, University of Washington, Seattle, Washington, USA
    Clin Pharmacol Ther 84:248-53. 2008
    ..evaluate the effects of pregnancy on CYP3A and P-glycoprotein (P-gp) activities, as measured by disposition of midazolam and digoxin, respectively. Thirteen women received digoxin (0.25 mg p.o.) and midazolam (2 mg p.o...
  87. ncbi Double-blind randomized controlled trial to determine extent of amnesia with midazolam given immediately before general anaesthesia
    R Bulach
    Department of Anaesthesia and Pain Management, Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia
    Br J Anaesth 94:300-5. 2005
    Anterograde, but not retrograde, amnesia has been demonstrated following midazolam administration. However, there have been no studies investigating whether or not immediate retrograde amnesia can be produced with midazolam.
  88. ncbi Bispectral analysis measures sedation and memory effects of propofol, midazolam, isoflurane, and alfentanil in healthy volunteers
    P S Glass
    Department of Anesthesiology, Duke University, Durham, North Carolina 27710, USA
    Anesthesiology 86:836-47. 1997
    ..This study was designed to evaluate this relation for four commonly used anesthetic drugs: propofol, midazolam, isoflurane, and alfentanil.
  89. ncbi Neural correlates of cat odor-induced anxiety in rats: region-specific effects of the benzodiazepine midazolam
    Iain S McGregor
    School of Psychology, University of Sydney, Sydney, New South Wales 2006, Australia
    J Neurosci 24:4134-44. 2004
    ..Rats received either midazolam (0.75 mg/kg, s.c...
  90. ncbi Reconsolidation of a morphine place preference: impact of the strength and age of memory on disruption by propranolol and midazolam
    M J F Robinson
    Department of Psychology, McGill University, 1205 Dr Penfield Ave, Montreal, Quebec, Canada
    Behav Brain Res 213:201-7. 2010
    ..reactivated drug-free, and immediately afterwards animals received an injection of propranolol (10mg/kg, SC), midazolam (1mg/kg, IP), both amnestic agents combined, or saline...
  91. ncbi Changes in respiratory pattern and arterial blood gases during sedation with propofol or midazolam in spinal anesthesia
    M Yamakage
    Department of Anesthesiology, Sapporo Medical University, School of Medicine, Hokkaido, Japan
    J Clin Anesth 11:375-9. 1999
    To investigate changes in respiratory pattern and arterial blood gases during sedation with propofol or midazolam in spinal anesthesia.
  92. ncbi Midazolam challenge reinduces neurological deficits after transient ischemic attack
    Ronald M Lazar
    From the Columbia University College of Physicians and Surgeons, Columbia Presbyterian Medical Center, New York, NY, USA
    Stroke 34:794-6. 2003
    ..Having previously shown that an experimental challenge with the GABAA agonist midazolam in recovered stroke patients can reinduce the acute clinical state, we determined whether TIA patients would ..
  93. ncbi Short-term effects of intravenous benzodiazepines on autonomic neurocardiac regulation in humans: a comparison between midazolam, diazepam, and lorazepam
    Marcus W Agelink
    Department of Neurocardiology, Institute of Biological Psychiatry and Neuroscience, Evangelical Clinics Gelsenkirchen, Ruhr University of Bochum, Germany
    Crit Care Med 30:997-1006. 2002
    To evaluate the effects of intravenously applied diazepam, lorazepam, and midazolam on autonomic neurocardiac regulation assessed by standardized measurements of heart rate variability.
  94. ncbi Randomized, controlled, cross-over clinical trial comparing intravenous midazolam sedation with nitrous oxide sedation in children undergoing dental extractions
    K E Wilson
    Department of Sedation, Newcastle Dental School and Hospital, Framlington Place, Newcastle upon Tyne NE2 4BW, UK
    Br J Anaesth 91:850-6. 2003
    ..A study was therefore designed to investigate the use of midazolam, for i.v. sedation in paediatric dental patients.
  95. ncbi The comparative dose-response effects of melatonin and midazolam for premedication of adult patients: a double-blinded, placebo-controlled study
    M Naguib
    Departments of Anesthesia, University of Iowa College of Medicine, Iowa City 52242 1009, USA
    Anesth Analg 91:473-9. 2000
    ..placebo-controlled study to compare the perioperative effects of different doses of melatonin and midazolam. Doses of 0.05, 0.1, or 0...
  96. ncbi Pharmacological properties of GABAA receptors containing gamma1 subunits
    S Khom
    Department of Pharmacology and Toxicology, University of Vienna, Austria
    Mol Pharmacol 69:640-9. 2006
    ..Triazolam, clotiazepam, midazolam, 2-(4-methoxyphenyl)-2,3,5,6,7,8,9,10-octahydro-cyclohepta-(b)pyrazolo[4,3-d]pyridin-3-one (CGS 20625), 2-(4-..
  97. ncbi Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism
    Yvonne S Lin
    Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, USA
    Mol Pharmacol 62:162-72. 2002
    ..Overall, CYP3A5 protein content accounted for 31% of the variability in hepatic midazolam hydroxylation activity...
  98. ncbi A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial
    Thomas Strøm
    Department of Anesthesia and Intensive Care Medicine, Odense University Hospital, University of Southern Denmark, Denmark
    Lancet 375:475-80. 2010
    ..We aimed to establish whether duration of mechanical ventilation could be reduced with a protocol of no sedation versus daily interruption of sedation...
  99. ncbi Randomized controlled trial of intramuscular droperidol versus midazolam for violence and acute behavioral disturbance: the DORM study
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, New South Wales, Australia
    Ann Emerg Med 56:392-401.e1. 2010
    We determine whether droperidol, midazolam, or the combination is more effective for intramuscular sedation in violent and acute behavioral disturbance in the emergency department (ED).
  100. ncbi Use of dexmedetomidine in the pediatric intensive care unit
    Marcia L Buck
    Department of Pharmacy Services, University of Virginia Children s Hospital, Charlottesville, Virginia 22908, USA
    Pharmacotherapy 28:51-7. 2008
    ..To determine the safety, effectiveness, and dosing of dexmedetomidine in intensive care infants and children who require sedation, and the rationale for patient selection...
  101. ncbi Influence of solute carriers on the pharmacokinetics of CYP3A4 probes
    R M Franke
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Clin Pharmacol Ther 84:704-9. 2008
    ..There was no significant correlation between the erythromycin breath test (ERMBT) parameters and midazolam clearance in 30 cancer patients (R(2) < 0.01), regardless of their CYP3A5 genotype status...

Research Grants72

  1. Maternal obesity depresses essential fatty acid transport in the placenta
    PERRIE F O'TIERNEY-GINN; Fiscal Year: 2012
    ..The proposed studies will help us understand how obesity during pregnancy alters the placental transfer of nutrients from mother to child and how this impacts neonatal nutrition. ..
  2. Maternal obesity depresses essential fatty acid transport in the placenta
    PERRIE F O'TIERNEY-GINN; Fiscal Year: 2013
    ..abstract_text> ..
  3. Intranasal CNS delivery of drugs against organophosphorous threat agents
    ..atropine to antagonize the action of excess acetylcholine formed at muscarinic receptors and 3) diazepam or midazolam to allosterically potentiate the action of inhibitory neurotransmitter -amino butyric acid (GABA) at GABAA ..
  4. Effectiveness and Safety of Antithrombotic Strategies after Joint Replacement
    Elaine Hylek; Fiscal Year: 2013
    ..The public health significance is enormous given the projected need for joint replacement in this patient population. ..
  5. Interventions Targeting Inflammation for Chemotherapy-Related Cognitive Problems
    MICHELLE C JANELSINS; Fiscal Year: 2013
    ..Janelsins'successful transition to an independent, R01- funded, clinical and translational investigator, and ultimately reduce the public health burden from CRCI. ..
  6. Regulation of Cytokinesis and Tumor Formation by RhoA
    ANN LOUISE MILLER; Fiscal Year: 2013
    ..Finally, I will test whether cytokinesis failure induced by other Rho zone regulators, especially those that are up- or down-regulated or mutated in human tumors, promotes tumor formation. ..
  7. Rational polytherapy in the treatment of cholinergic seizures
    Claude G Wasterlain; Fiscal Year: 2013
    ..We propose to explore combinations of the following drugs: 1/ Midazolam, a GABAA receptor agonist which is easily delivered intra-muscularly...
  8. New York-Presbyterian NETT Consortium
    Stephan A Mayer; Fiscal Year: 2011
    ..of therapeutic hypothermia after cardiac arrest, the Merci'clot retriever for acute ischemic stroke, midazolam infusion for refractory status epilepticus, and clinical trials evaluating neuroprotective agents for acute ..
  9. PGRMC1: A Regulator of CYP3A Activity
    Erin G Schuetz; Fiscal Year: 2010
    ..by showing, among 530 human livers, a significant correlation between CYP3A4 mediated metabolism of both midazolam and testosterone and PGRMC1 mRNA expression, and a PGRMC1 associated genotype...
  10. Genetic Architecture of Rheumatoid Arthritis in African-Americans
    MARIA IOANA DANILA; Fiscal Year: 2013
    ..This project will greatly improve our understanding of the genetic influences on the RA risk and outcome and will provide essential training for Dr. Danila'development as an independent investigator. ..
  11. Emerging Infectious Diseases Training Program
    Kathleen A McDonough; Fiscal Year: 2013
    ..This application proposes to train pre- and postdoctoral scientists to combat such threats to the nation's public health. ..
  12. Caloric restriction and Alzheimers ABeta clearance pathway
    Berislav V Zlokovic; Fiscal Year: 2013
    ..We expect the proposal will establish a long-standing collaboration between the Zlokovic group and the LMIC site/PI's group. ..
  13. Training Program in Stem Cell and Regenerative Developmental Biology
    ..Career training opportunities in the form of group discussions and individual access are also presented. ..
  14. Sleep Intervention During Acute Lung Injury
    Sairam Parthasarathy; Fiscal Year: 2013
    ..strategies: central 12 adrenergic sedative-analgesic (dexmedetomidine) versus a conventional sedation strategy (midazolam and fentanyl) in a randomized, double blind, cross-over study...
  15. Design of New Therapeutic Agents to Treat Schizophrenia
    James M Cook; Fiscal Year: 2013
    ..The proposed work is significant because it represents the first step in a continuum of research to develop the first therapies for impaired cognitive function and negative symptoms of schizophrenia patients. ..
  16. Center for Health Insurance Reform, Cardiovascular Outcomes, and Disparities
    Nancy R Kressin; Fiscal Year: 2013
    Michael F McNitt-Gray; Fiscal Year: 2013
    ..It has the programmatic infrastructure in place for the program, it continues to innovate both in research and in teaching and most important, it has a dedicated and outstanding faculty. ..
  18. Multidisciplinary approaches to tumor immunology
    Kelvin P Lee; Fiscal Year: 2013
  19. Effects of general vs. regional anesthesia on infant neurodevelopment and apnea
    Mary Ellen McCann; Fiscal Year: 2013
    ..Studies in animal models provide compelling evidence that commonly used agents (e.g., isoflurane, midazolam, nitrous oxide) enhance neuronal cell death in the immature brain, in some studies at doses lower than those ..
  20. Mentored Research on Improving Alcohol Brief Interventions in MedicalSettings
    JENNIFER ELIN HETTEMA; Fiscal Year: 2013
    ..The proposed research, along with my training plan, will contribute to my training goals of gaining mixed-methods Stage I research skills and experience in medical culture and research. ..
  21. Virology of the Central Nervous System
    John H Elder; Fiscal Year: 2010
    ..Appointments will be for a minimum of two years, with three years the norm. ..
  22. Transdisciplinary Training for Predoctoral Behavioral Scientists
    Melbourne F Hovell; Fiscal Year: 2012
    ..This training program will equip behavioral scientists with the biological/biomedical background necessary to work collaboratively with biomedical investigators to prevent and control disease in populations. ..
  23. Characterization of a Novel Selective Cytochrome P450 3A5 Substrate
    MICHAEL DARIN CAMERON; Fiscal Year: 2013
    ..of almost every approved compound is generated using a CYP3A assay measuring testosterone hydroxylation or midazolam hydroxylation by pooled human liver microsomes...
  24. Oxidized-LDL, LOX-1 and angiogenesis
    Jawahar L Mehta; Fiscal Year: 2013
    ..Information gained from this study may also have relevance in the development of cancers which are dependent of neovasculature for their growth. ..
    Michael A Froelich; Fiscal Year: 2010
    ..fashion, using established psychometric methods, the dose-dependent effect of two GABA-acting (propofol and midazolam) and one alpha-2-receptor agonist (dexmedetomidine) sedative drugs on the sensory-discriminative and the hedonic ..
  26. State University of New York (SUNY) Downstate NETT Clinical Site Hub
    STEVEN RICHARD LEVINE; Fiscal Year: 2013
  27. Impact of Hypothermia on Midazolam and Morphine Pharmacokinetics
    Athena F Zuppa; Fiscal Year: 2013
    ..Thus, our overarching hypothesis is that morphine and midazolam disposition will be affected by temperature management even when accounting for potentially confounding ..
    Graeme Mardon; Fiscal Year: 2012
    ..This program is designed to train new investigators with the appropriate knowledge and skills to make such contributions...
  29. Drugs of Abuse and Memory Span
    JOSEPH MARK GALIZIO; Fiscal Year: 2012
    ..have amnestic effects on olfactory memory using the span procedure including benzodiazepines (chlordiazepoxide, midazolam), NMDA antagonists (dizocilpine, ketamine), opiates (morphine), psychostimulants (methylphenidate, ..
  30. Predoctoral Training Program in Human Genetics
    David Valle; Fiscal Year: 2013
    ..The success of our graduates, who obtain postdoctoral positions in top laboratories and go on to productive academic careers in top universities, strongly supports this conclusion. ..
  31. Biomedical-Behavioral Interface: Prevention and Developmental Sciences Training
    Ronald J Prinz; Fiscal Year: 2013
  32. Transplant Social Worker Support for Live Kidney Donation in African Americans
    LEIGH E BOULWARE; Fiscal Year: 2013
    ..The proposed study leverages our multidisciplinary team's substantial prior experience studying culturally sensitive interventions to overcome barriers to LDKT among African Americans. ..
  33. Postdoctoral Research Training in Eating Disorders
    Cynthia M Bulik; Fiscal Year: 2013
    ..Our trainees will continue their track record of successful proposals to NIH and other funding bodies to become established independent investigators and elevate eating disorders to the next level of scientific sophistication. ..
  34. UK NETT Clinical Site Hub
    ROGER LOYD HUMPHRIES; Fiscal Year: 2013
    ..more than 50 subjects in the Phase 111 clinical trials undertaken within the NETT Network, to include RAMPART (midazolam v. lorazepam in status epilepticus), ALIAS Part 2 (albumin v...
  35. Interdisciplinary Training in Systems and Developmental Biology and Birth Defects
    Ethylin Wang Jabs; Fiscal Year: 2013
    ..This proposed training will undoubtedly produce future scientists ready for the new frontier of systems and developmental biology. ..
  36. Veterinarian Training in Laboratory Animal Medicine
    Craig L Franklin; Fiscal Year: 2013
    ..On completion of the training program, trainees will have acquired the necessary skills to become successful laboratory animal veterinarians, leaders in their field and invaluable contributors to biomedical research. ..
    Ramaswamy Govindan; Fiscal Year: 2013
  38. Garlic Metabolism and Cytochrome P450 Modulation
    Danny Shen; Fiscal Year: 2007
    ..caffeine (1A2), buproprion (2B6), chlorzoxazone (2E1), tolbutamide (2C9), omeprazole (2C19), metoprolol (2D6), midazolam (3A4/5), and digoxin (Pgp), will be administered to a panel of healthy human volunteers at various times during ..
  39. Transplant Surgery Scientist Training Program
    Michael M Abecassis; Fiscal Year: 2013
    ..Both tracks are required to take coursework in the responsible conduct of research. Both tracks uniquely prepare trainees to perform innovative, state-of-the-art research in transplant-related fields. ..
  40. Ontogeny of Voriconazole Pharmaockinetics and Metabolism
    Michael N Neely; Fiscal Year: 2013
    ..of the IV voriconazole dose prior to the PK sampling, we will also give single IV microdoses of esomeprazole, midazolam, and ranitidine as a cocktail to probe CYP2C19, CYP3A4, and FOM3 activity, respectively...
  41. White matter degeneration: biomarkers in preclinical Alzheimer's Disease
  42. Cancer Nanotechnology in Imaging and Radiotherapy
    Gayle E Woloschak; Fiscal Year: 2013
    ..of Radiology and of Radiation &Cellular Oncology at the University of Chicago. The program will have strong links to Northwestern's Center for Cancer Nanotechnology Excellence. ..
  43. Prostanoid Modulators that Reduce Brain Injury After Seizures
    Raymond J Dingledine; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Current medical countermeasures to nerve gas exposure such as midazolam and atropine are of doubtful general utility for civilian populations because they must be administered within minutes of an ..
    JULIETTE T LECOMTE; Fiscal Year: 2013
  45. Characterization of Toxicity with Spinal Opiates
    Tony L Yaksh; Fiscal Year: 2010
    ..Hypothesis 4. Clonidine (alpha2 agonist) and midazolam (benzodiazepine) suppress MC activation and this will diminish granuloma formation...
  46. Replacement of GC Mass Spectrometer
    Michael J Thomas; Fiscal Year: 2010
    ..Replacing our GC/MS with a new instrument having added capabilities will enhance the timely completion of NIH-funded research. ..
  47. CRCNS:Dissecting brain-computer interfaces:a manifold &feedback-control approach
    BYRON MING SHI YU; Fiscal Year: 2013
    ..abstract_text> ..
  48. Molecular and Applied Nutrition Training Program
    Richard S Eisenstein; Fiscal Year: 2013
    ..With renewed NIH support, the MANTP will continue to grow and refine its mission to provide the US scientific community with expertly trained PhD and MD nutritional scientists. ..
  49. Ketamine vs Midazolam: Testing Rapid Relief of Suicide Risk in Depression
    Michael F Grunebaum; Fiscal Year: 2013
    ..a rigorous clinical trial in suicidal depressed patients to test random assignment to IV infusion of ketamine or midazolam control followed by open continuation treatment with antidepressant medication plus supportive case management...
  50. Immunology of Infectious Disease
    JoAnne L Flynn; Fiscal Year: 2013
    ..Two post-doctoral slots, at a level of 1-3 years post-degree, per year are requested. ..
  51. The Functional Anatomy of Adolescent ADHD: Defining Markers of Recovery
    Katerina Velanova; Fiscal Year: 2012
  52. Training in Burn and Trauma Research
    RONALD GARY TOMPKINS; Fiscal Year: 2013
  53. Integrated, Interdisciplinary, Inter-university PHD Program Computational Biology
    Panagiotis V Benos; Fiscal Year: 2013
    ..In addition to training the specific supported students, the program will aid in the development of novel teaching materials and practices of benefit to other training programs in computational biology. ..
  54. Optimization of IV Ketamine for Treatment Resistant Major Depression
    Sanjay J Mathew; Fiscal Year: 2012
    ..a single IV infusion of ketamine has superior antidepressant efficacy compared to an active control agent (IV midazolam) in patients with TRD...
    James E Schwob; Fiscal Year: 2013
    ..Our Program has graduated 68 trainees since its inception and 33 are currently enrolled. Five additional trainees are slated to matriculate this June. We are requesting funding for 12 positions in this application. ..
  56. Expert Memory: Superior Encoding, Enhanced Retrieval, and Refined Perception
    TIMOTHY E CURRAN; Fiscal Year: 2013
    ..Finally, the drug midazolam will be used to simulate anterograde amnesia to gain a better understanding of how amnesia affects expert memory ..
  57. Tumor NMR Images are Affected by Anesthetic
    Natarajan Raghunand; Fiscal Year: 2006
    ..pentobarbital, and isoflurane, and one customized injectable anesthetic protocol: etomidate/fentanyl/midazolam. These investigations will be accomplished in SCID mice bearing HT-29 colon carcinoma xenografts...
  58. Drug Metabolism and Chronic Liver Disease
    Robert Branch; Fiscal Year: 2005
    ..Part 2: Semi-simultaneous oral:intravenous administration with midazolam to measure intestinal and hepatic contributions to CYP3A metabolism and Part 3: oral administration of ..
  59. Training Program in Viral Replication
    Laimonis A Laimins; Fiscal Year: 2013
    ..This is the goal ofthe current Viral Replication Training Program (VRTG) at Northwestern...
  60. Herb-Opioid Interactions
    Danny Shen; Fiscal Year: 2003
    ..and hepatic CYP3A4 through intravenous and oral administrations of a CYP3A-specific, in vivo catalytic probe -midazolam. The fentanyl arm of the study will 1) assess the effects of SJW on the brain uptake and efflux kinetics of ..
    Bruce Barton; Fiscal Year: 2001
    ..5 percent of neonates during NICU care or invasive procedures. A pilot randomized trial of morphine, midazolam, or placebo therapy in 69 preterm neonates showed reduced behavioral responses to pain and evidence of decreased ..
  62. The Effect of Glutamatergic Modulation on Cocaine Self-Administration
    Elias Dakwar; Fiscal Year: 2013
    ..We predict that, compared to midazolam, ketamine will significantly reduce the number of cocaine choices during the choice session...
    STEVEN SHEDLOFSKY; Fiscal Year: 2003
    ..P450 activities will be determined using the drug probes chlorzoxazone for CYP2EI and midazolam for CYP3A4. Theophylline will be used for CYP1A2...
  64. Interdisciplinary Training in Kidney-Related Research
    Anupam Agarwal; Fiscal Year: 2013
    ..Fellows completing the program will be competitive candidates for academic research careers. ..
  65. Mentored Patient-Oriented Research Career Development Aw
    Kelly Young; Fiscal Year: 2004
    ..of the long-term effects of painful experiences; and 4) to test a pharmacological (intramuscular ketamine and midazolam) and a behavioral (blowing on a party blower) intervention for reducing the pain and stress response...
    William E Carson; Fiscal Year: 2013
    ..Since the last renewal, four trainees from under-represented groups were recruited to this training program. ..
    Ferenc Gyulai; Fiscal Year: 2004
    ..antagonist, proves to be insensitive to increasing doses of muscimol, the binding of the benzodiazepine agonist midazolam will be used as a probe for GABAA-R function by measuring the displacement of 11C-FMZ by midazolam...
  68. FMRI Study of the Effects of DBS in Primary Generalized Dystonia (K23)
    Benjamin L Walter; Fiscal Year: 2010
    ..This information may be useful for the treatment of other neurologic and psychiatric disorders for which DBS is now being explored. ..
  69. Impact of Pharmacology on Duration of Ventilation in Patients with Resp Failure
    Athena F Zuppa; Fiscal Year: 2012
    ..Thus our hypothesis is that midazolam and morphine drug exposure and response will be affected by both non-heritable (e.g...
  70. Training in Biomedical Informatics at Columbia University
    GEORGE M HRIPCSAK; Fiscal Year: 2013
    ..The faculty, research staff, and students form a critical mass for providing a provocative environment for the seminars, journal clubs, and discussions. ..
    Stephen Hall; Fiscal Year: 1999
    ..intestinal availability, intestinal intrinsic clearance, hepatic availability and hepatic intrinsic clearance of midazolam will be quantified in young and elderly, male and female human volunteers...
    RICHARD MEISCH; Fiscal Year: 1999
    ..Thus, a training or acquisition procedure is necessary. With midazolam a fading procedure was used whereby increasing amounts of drug were added to an ethanol solution (that was ..