trimethoprim sulfamethoxazole combination

Summary

Summary: This drug combination has proved to be an effective therapeutic agent with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.

Top Publications

  1. ncbi Co-trimoxazole as prophylaxis against opportunistic infections in HIV-infected Zambian children (CHAP): a double-blind randomised placebo-controlled trial
    C Chintu
    University Teaching Hospital, Lusaka, Zambia
    Lancet 364:1865-71. 2004
  2. ncbi The role of horizontal gene transfer in the spread of trimethoprim-sulfamethoxazole resistance among uropathogenic Escherichia coli in Europe and Canada
    Matthew T Blahna
    Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor, 48109, USA
    J Antimicrob Chemother 57:666-72. 2006
  3. ncbi Widespread distribution of urinary tract infections caused by a multidrug-resistant Escherichia coli clonal group
    A R Manges
    Division of Epidemiology and Public Health Biology, School of Public Health, University of California at Berkeley, 94720, USA
    N Engl J Med 345:1007-13. 2001
  4. ncbi A disseminated multidrug-resistant clonal group of uropathogenic Escherichia coli in pyelonephritis
    James R Johnson
    Medical Service, Minneapolis VA Medical Center and Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    Lancet 359:2249-51. 2002
  5. ncbi Initiating co-trimoxazole prophylaxis in HIV-infected patients in Africa: an evaluation of the provisional WHO/UNAIDS recommendations
    M Badri
    Infectious Diseases Clinical Research Unit, Lung Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    AIDS 15:1143-8. 2001
  6. ncbi Effect of cotrimoxazole prophylaxis taken by human immunodeficiency virus (HIV)-infected persons on the selection of sulfadoxine-pyrimethamine-resistant malaria parasites among HIV-uninfected household members
    Samuel S Malamba
    Centers for Disease Control and Prevention Uganda, Global AIDS Program, National Center for HIV, STD and TB Prevention, Entebbe, Uganda
    Am J Trop Med Hyg 75:375-80. 2006
  7. pmc Class 1 integrons increase trimethoprim-sulfamethoxazole MICs against epidemiologically unrelated Stenotrophomonas maltophilia isolates
    Raquel Barbolla
    Departamento de Microbiologia, Parasitologia e Inmunologia, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Antimicrob Agents Chemother 48:666-9. 2004
  8. ncbi Multidrug-resistant Escherichia coli clonal groups causing community-acquired pyelonephritis
    Amee R Manges
    Division of Epidemiology, School of Public Health, University of California at Berkeley, 94720, USA
    Clin Infect Dis 38:329-34. 2004
  9. ncbi Randomized trial of 2-dose versus monthly sulfadoxine-pyrimethamine intermittent preventive treatment for malaria in HIV-positive and HIV-negative pregnant women in Malawi
    Scott J Filler
    Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 194:286-93. 2006
  10. pmc Role of co-trimoxazole prophylaxis in reducing mortality in HIV infected adults being treated for tuberculosis: randomised clinical trial
    Andrew J Nunn
    Medical Research Council Clinical Trials Unit, London NW1 2DA
    BMJ 337:a257. 2008

Detail Information

Publications272 found, 100 shown here

  1. ncbi Co-trimoxazole as prophylaxis against opportunistic infections in HIV-infected Zambian children (CHAP): a double-blind randomised placebo-controlled trial
    C Chintu
    University Teaching Hospital, Lusaka, Zambia
    Lancet 364:1865-71. 2004
    ..We aimed to assess the efficacy of daily co-trimoxazole in such an area...
  2. ncbi The role of horizontal gene transfer in the spread of trimethoprim-sulfamethoxazole resistance among uropathogenic Escherichia coli in Europe and Canada
    Matthew T Blahna
    Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor, 48109, USA
    J Antimicrob Chemother 57:666-72. 2006
    ....
  3. ncbi Widespread distribution of urinary tract infections caused by a multidrug-resistant Escherichia coli clonal group
    A R Manges
    Division of Epidemiology and Public Health Biology, School of Public Health, University of California at Berkeley, 94720, USA
    N Engl J Med 345:1007-13. 2001
    ..coli strains with resistance to trimethoprim-sulfamethoxazole. The widespread distribution and high prevalence of E. coli clonal group A has major public health implications...
  4. ncbi A disseminated multidrug-resistant clonal group of uropathogenic Escherichia coli in pyelonephritis
    James R Johnson
    Medical Service, Minneapolis VA Medical Center and Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    Lancet 359:2249-51. 2002
    ..Thus, CGA is broadly disseminated and contributes to co-trimoxazole resistance in pyelonephritis as well as in cystitis...
  5. ncbi Initiating co-trimoxazole prophylaxis in HIV-infected patients in Africa: an evaluation of the provisional WHO/UNAIDS recommendations
    M Badri
    Infectious Diseases Clinical Research Unit, Lung Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    AIDS 15:1143-8. 2001
    ..Further studies are needed to assess the optimal time of commencement of prophylaxis, as widespread co-trimoxazole use will lead to increasing antimicrobial resistance to other major pathogens in Africa...
  6. ncbi Effect of cotrimoxazole prophylaxis taken by human immunodeficiency virus (HIV)-infected persons on the selection of sulfadoxine-pyrimethamine-resistant malaria parasites among HIV-uninfected household members
    Samuel S Malamba
    Centers for Disease Control and Prevention Uganda, Global AIDS Program, National Center for HIV, STD and TB Prevention, Entebbe, Uganda
    Am J Trop Med Hyg 75:375-80. 2006
    ....
  7. pmc Class 1 integrons increase trimethoprim-sulfamethoxazole MICs against epidemiologically unrelated Stenotrophomonas maltophilia isolates
    Raquel Barbolla
    Departamento de Microbiologia, Parasitologia e Inmunologia, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Antimicrob Agents Chemother 48:666-9. 2004
    ..These results support not only the higher spread of class 1 integrons compared to other mechanisms but also the potential limitation of using trimethoprim-sulfamethoxazole for therapy of severe S. maltophilia infections...
  8. ncbi Multidrug-resistant Escherichia coli clonal groups causing community-acquired pyelonephritis
    Amee R Manges
    Division of Epidemiology, School of Public Health, University of California at Berkeley, 94720, USA
    Clin Infect Dis 38:329-34. 2004
    ..coli strains had unique fingerprints (P<.001). The prevalence of antimicrobial-resistant pyelonephritis in a community may be affected by a limited number of E. coli clonal groups...
  9. ncbi Randomized trial of 2-dose versus monthly sulfadoxine-pyrimethamine intermittent preventive treatment for malaria in HIV-positive and HIV-negative pregnant women in Malawi
    Scott J Filler
    Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 194:286-93. 2006
    ..However, the optimal regimen in the setting of a high prevalence of human immunodeficiency virus (HIV) infection remains unclear...
  10. pmc Role of co-trimoxazole prophylaxis in reducing mortality in HIV infected adults being treated for tuberculosis: randomised clinical trial
    Andrew J Nunn
    Medical Research Council Clinical Trials Unit, London NW1 2DA
    BMJ 337:a257. 2008
    ..To assess the impact of prophylactic oral co-trimoxazole in reducing mortality in HIV positive Zambian adults being treated for pulmonary tuberculosis...
  11. pmc Impact of trimethoprim-sulfamethoxazole prophylaxis on falciparum malaria infection and disease
    Mahamadou A Thera
    Bandiagara Malaria Project, Malaria Research and Training Center, University of Bamako, Mali
    J Infect Dis 192:1823-9. 2005
    ..CONCLUSIONS. In this setting of low antifolate resistance, TS was highly effective in preventing falciparum malaria infection and disease and did not appear to select for SP-resistant parasites...
  12. ncbi Topical bactrim versus trimethoprim and sulfonamide against nocardia keratitis
    L H Lee
    Department of Ophthalmology, Westchester Medical Center, New York Medical College, Valhalla 10595, USA
    Cornea 20:179-82. 2001
    ..Recently, topical trimethoprim and sulfamethoxazole (Bactrim) has been suggested as treatment. This study compares the in vitro efficacy against Nocardia asteroides of Bactrim and various ratios of trimethoprim and a sulfonamide...
  13. ncbi Early chemoprophylaxis with trimethoprim-sulphamethoxazole for HIV-1-infected adults in Abidjan, Côte d'Ivoire: a randomised trial. Cotrimo-CI Study Group
    X Anglaret
    Centre de Diagnostic et de Recherches sur le SIDA, CHU de Treichville, Abidan, Cote d Ivoire
    Lancet 353:1463-8. 1999
    ....
  14. ncbi Antibiotic susceptibility of Burkholderia pseudomallei from tropical northern Australia and implications for therapy of melioidosis
    A W Jenney
    Infectious Diseases Unit, Royal Darwin Hospital, Darwin, NT 0810, Australia
    Int J Antimicrob Agents 17:109-13. 2001
    ....
  15. ncbi Q fever during pregnancy: diagnosis, treatment, and follow-up
    Didier Raoult
    Unite des Rickettsies, Universite de la Mediterranee, Faculte de Medecine, CNRS UMR 6020, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    Arch Intern Med 162:701-4. 2002
    ..Q fever, caused by Coxiella burnetii, may result in abortions, premature deliveries, and stillbirths in infected pregnant women...
  16. ncbi Effect of co-trimoxazole prophylaxis on morbidity, mortality, CD4-cell count, and viral load in HIV infection in rural Uganda
    Jonathan Mermin
    CDC Uganda, Global AIDS Program, National Center for HIV, STD and TB Prevention, National Center for Infectious Diseases Centers for Disease Control and Prevention, Atlanta, GA, USA
    Lancet 364:1428-34. 2004
    ..We assessed the effect of such prophylaxis on morbidity, mortality, CD4-cell count, and viral load among people with HIV infection living in rural Uganda, an area with high rates of bacterial resistance to co-trimoxazole...
  17. ncbi Lower early mortality rates among patients receiving antiretroviral treatment at clinics offering cotrimoxazole prophylaxis in Malawi
    David Lowrance
    HIV AIDS Care and Treatment Branch, Global AIDS Program, Us centers for Disease Control and Prevention CDC, Atlanta, GA, USA
    J Acquir Immune Defic Syndr 46:56-61. 2007
    ..To determine whether Malawi antiretroviral treatment (ART) clinics providing cotrimoxazole (CTX) prophylaxis had lower early mortality rates compared with clinics not providing CTX...
  18. ncbi Trimethoprim-sulfamethoxazole revisited
    Philip A Masters
    Division of General Internal Medicine, The Pennsylvania State University College of Medicine, 500 University Dr, Suite 4100, Hershey, PA 17033, USA
    Arch Intern Med 163:402-10. 2003
    ..In addition, trimethoprim-sulfamethoxazole continues to be the drug of choice for several clinical indications...
  19. ncbi Prevalence of antimicrobial resistance among urinary tract pathogens isolated from female outpatients across the US in 1999
    J A Karlowsky
    MRL, Suite 200, 13665 Dulles Technology Drive, Herndon, VA 20171, USA
    Int J Antimicrob Agents 18:121-7. 2001
    ..As resistance among uropathogens reaches clinically significant levels in many areas, continued regional surveillance is essential to ensure the provision of effective empiric therapy for urinary tract infections...
  20. pmc Cotrimoxazole prophylaxis reduces mortality in human immunodeficiency virus-positive tuberculosis patients in Karonga District, Malawi
    Frank B D Mwaungulu
    Karonga Prevention Study, Karonga, Malawi
    Bull World Health Organ 82:354-63. 2004
    ..To estimate the impact of cotrimoxazole prophylaxis on the survival of human immunodeficiency virus (HIV)-positive tuberculosis (TB) patients...
  21. ncbi Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity
    M Pirmohamed
    Department of Pharmacology and Terapeutics, The University of Liverpool, UK
    Pharmacogenetics 10:705-13. 2000
    ..Our results show that genetic polymorphisms in drug metabolizing enzymes are unlikely to be major predisposing factors in determining individual susceptibility to co-trimoxazole hypersensitivity in HIV-positive patients...
  22. ncbi Efficacy of trimethoprim-sulphamethoxazole prophylaxis to decrease morbidity and mortality in HIV-1-infected patients with tuberculosis in Abidjan, Côte d'Ivoire: a randomised controlled trial
    S Z Wiktor
    Projet RETRO CI, Abidjan, Cote d Ivoire
    Lancet 353:1469-75. 1999
    ..We assessed the safety and efficacy of trimethoprim-sulphamethoxazole 800 mg/160 mg (co-trimoxazole) prophylaxis in prevention of such infections and in decrease of morbidity and mortality...
  23. ncbi Efficacy and safety of two dosages of cotrimoxazole as preventive treatment for HIV-infected Malawian adults with new smear-positive tuberculosis
    Martin J Boeree
    Department of Medicine, University of Malawi, College of Medicine, Blantyre, Malawi
    Trop Med Int Health 10:723-33. 2005
    ..To assess the efficacy and safety of two different dosages of cotrimoxazole (CTX) in prophylaxis in HIV-positive new smear-positive pulmonary tuberculosis (TB) patients in Blantyre, Malawi...
  24. ncbi Effects of trimethoprim-sulfamethoxazole and insecticide-treated bednets on malaria among HIV-infected Ugandan children
    Moses R Kamya
    Makerere University Medical School, Kampala, Uganda
    AIDS 21:2059-66. 2007
    ..The efficacy of TMP/SMX may be diminished where antifolate resistance to malaria is high. We evaluated the efficacy of these interventions for malaria prevention among Ugandan children...
  25. ncbi Managing Q fever during pregnancy: the benefits of long-term cotrimoxazole therapy
    Xavier Carcopino
    Service de Gynecologie Obstetrique, Hopital Nord, Chemin des Bourrely, France
    Clin Infect Dis 45:548-55. 2007
    ..During pregnancy, it may result in obstetric complications, such as spontaneous abortion, intrauterine growth retardation, intrauterine fetal death, and premature delivery. Pregnant women are exposed to the risk of chronic Q fever...
  26. ncbi [Wegener's granulomatosis]
    Christian Pagnoux
    Service de Medecine Interne, Centre de référence national maladies rares, vascularites nécrosantes et sclérodermies, Hopital Cochin, AP HP, université Paris V René Descartes, Paris, France
    Presse Med 36:860-74. 2007
    ..Today, however, they are reserved for refractory cases...
  27. ncbi Trimethoprim-sulphamethoxazole for the treatment of Wegener's granulomatosis
    R A DeRemee
    Rheumatology (Oxford) 42:396; author reply 396-7. 2003
  28. ncbi Efficacy and safety of ciprofloxacin oral suspension versus trimethoprim-sulfamethoxazole oral suspension for treatment of older women with acute urinary tract infection
    I H Gomolin
    Gurwin Jewish Geriatric Center, Commack, New York 11725, USA
    J Am Geriatr Soc 49:1606-13. 2001
    ..Furthermore, CIP suspension was associated with significantly lower rates of adverse events and premature discontinuations compared with TMP/SMX suspension...
  29. ncbi Effectiveness of cotrimoxazole prophylaxis on mortality in adults with tuberculosis in rural South Africa
    Kate Grimwade
    Hlabisa Hospital, KwaZulu Natal, South Africa
    AIDS 19:163-8. 2005
    ..Adults with dual tuberculosis (TB) and HIV infection have a poor outcome. Studies in West Africa suggest that cotrimoxazole prophylaxis may reduce this mortality...
  30. ncbi Evaluation of suspected urinary tract infection in ambulatory women: a cost-utility analysis of office-based strategies
    H C Barry
    Department of Family Practice, Michigan State University, East Lansing 48824 1313, USA
    J Fam Pract 44:49-60. 1997
    ..Several office-based management strategies are considered: empiric therapy, use of dipstick analysis, use of complete urinalysis, and several strategies using office or laboratory cultures...
  31. ncbi Efficacy of trimethoprim-sulfamethoxazole for the prevention of bacterial infections in a randomized prophylaxis trial of patients with advanced HIV infection
    A Gregory DiRienzo
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    AIDS Res Hum Retroviruses 18:89-94. 2002
    ....
  32. ncbi A randomized trial of the discontinuation of primary and secondary prophylaxis against Pneumocystis carinii pneumonia after highly active antiretroviral therapy in patients with HIV infection. Grupo de Estudio del SIDA 04/98
    J C Lopez Bernaldo de Quiros
    Hospital Universitario Gregorio Maranon, Madrid, Spain
    N Engl J Med 344:159-67. 2001
    ..carinii pneumonia. However, it is not clear whether prophylaxis can be safely discontinued after CD4 cell counts increase in response to highly active antiretroviral therapy...
  33. ncbi Rapid emergence of resistance to penicillin and trimethoprim-sulphamethoxazole in invasive Streptococcus pneumoniae in Zimbabwe
    Lovemore Gwanzura
    Department of Medical Laboratory Science, University of Zimbabwe Medical School, PO Box A178 Avondale, Harare, Zimbabwe
    Int J Antimicrob Agents 21:557-61. 2003
    ..Resistance to TMP-SMX was common, with more than 50% isolates from HIV positive and HIV negative patients having reduced susceptibility to this antibiotic combination...
  34. ncbi Adverse reactions of nitrofurantoin, trimethoprim and sulfamethoxazole in children
    Edward Karpman
    Department of Urology, University of California Davis Children s Hospital and School of Medicine, Sacramento, California 95817, USA
    J Urol 172:448-53. 2004
    ..We present a concise and relevant review on the use and adverse reactions of nitrofurantoin, trimethoprim and sulfamethoxazole in children...
  35. ncbi Increasing resistance to fluoroquinolones in escherichia coli from urinary tract infections in the netherlands
    W Goettsch
    National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    J Antimicrob Chemother 46:223-8. 2000
    ..coli from UTI may stem from increased prescription of fluoroquinolones for UTI. Resistance of E. coli to these agents is likely to increase further as fluoroquinolone use increases in future...
  36. pmc Antimicrobial sensitivity in enterobacteria from AIDS patients, Zambia
    James Mwansa
    School of Medicine, University of Zambia, University Teaching Hospital, Lusaka, Zambia
    Emerg Infect Dis 8:92-3. 2002
    ..Vaccine samples tested by nonmilitary laboratories were negative for viable mycoplasma and mycoplasma DNA and did not support its survival. Mycoplasma contamination of anthrax vaccine should not be considered a possible cause of illness...
  37. ncbi Comparison of ciprofloxacin (7 days) and trimethoprim-sulfamethoxazole (14 days) for acute uncomplicated pyelonephritis pyelonephritis in women: a randomized trial
    D A Talan
    Department of Medicine, Olive View UCLA Medical Center, University of California, Los Angeles 91342, USA
    JAMA 283:1583-90. 2000
    ..The optimal antimicrobial regimen and treatment duration for acute uncomplicated pyelonephritis are unknown...
  38. ncbi Quinolone resistance in female outpatient urinary tract isolates of Escherichia coli: age-related differences
    M Gobernado
    Department of Microbiology, University Hospital La Fe, Valencia, Spain
    Rev Esp Quimioter 20:206-10. 2007
    ..Being older than 65 years of age was associated with higher resistance rates to ciprofloxacin (29%). These results should be considered when recommending empirical therapy for acute cystitis in women...
  39. pmc Tuberculosis and trimethoprim-sulfamethoxazole
    Pierre Forgacs
    Department of Infectious Diseases and Research, Lahey Clinic, 41 Mall Rd, Burlington, MA 01805, USA
    Antimicrob Agents Chemother 53:4789-93. 2009
    ..We feel that a clinical trial looking at the effectiveness of TMP-SMX as an antituberculous drug is worthwhile...
  40. pmc HIV-associated TB in An Giang Province, Vietnam, 2001-2004: epidemiology and TB treatment outcomes
    Trinh Thanh Thuy
    Global AIDS Program, U S Centers for Disease Control and Prevention, Hanoi, Vietnam
    PLoS ONE 2:e507. 2007
    ..To help guide policy in Vietnam, we studied the epidemiology of HIV-associated TB in one province and examined factors associated with outcomes, including the impact of CTX use...
  41. ncbi Emergence of trimethoprim-sulfamethoxazole resistance in the AIDS era
    J N Martin
    Center for AIDS Prevention Studies and Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
    J Infect Dis 180:1809-18. 1999
    ..A rapid increase in the use of prophylactic TMP-SMX in HIV disease was also observed during this time in San Francisco and is likely responsible for the increase in TMP-SMX resistance...
  42. ncbi Congenital brucellosis: a rare cause of respiratory distress in neonates
    Kosmas Sarafidis
    1st Department of Neonatology, Aristotle University, Hippokration General Hospital, Thessaloniki, Greece
    Am J Perinatol 24:409-12. 2007
    ..The neonate was successfully treated with trimethoprim-sulfamethoxazole, rifampicin, and gentamicin...
  43. ncbi Effect of cotrimoxazole on causes of death, hospital admissions and antibiotic use in HIV-infected children
    Veronica Mulenga
    University Teaching Hospital, Lusaka, Zambia
    AIDS 21:77-84. 2007
    ..Cotrimoxazole prophylaxis reduces morbidity and mortality in HIV-1-infected children, but mechanisms for these benefits are unclear...
  44. pmc Monitoring the scale-up of antiretroviral therapy programmes: methods to estimate coverage
    J Ties Boerma
    The World Health Organization, Geneva, Switzerland
    Bull World Health Organ 84:145-50. 2006
    ..The mid-2005 estimate of 970,000 people receiving ART in low- and middle-income countries (with an uncertainty range 840,000-1,100,000) corresponds to a coverage of 15% of people in need of treatment...
  45. ncbi Conventional and molecular epidemiology of trimethoprim-sulfamethoxazole resistance among urinary Escherichia coli isolates
    William J Burman
    Department of Public Health, Denver Health and Hospital Authority, Colorado 80204, USA
    Am J Med 115:358-64. 2003
    ..We evaluated the epidemiology of trimethoprim-sulfamethoxazole-resistant E. coli in a large, public health care system in Denver, Colorado...
  46. pmc Risk factors for trimethoprim-sulfamethoxazole resistance in patients with acute uncomplicated cystitis
    Richard Colgan
    Department of Family Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Antimicrob Agents Chemother 52:846-51. 2008
    ..TMP-SMX r isolates were more likely to belong to CGA. Knowledge of these risk factors for TMP-SMX resistance could facilitate the accurate selection of empirical therapy...
  47. ncbi Trimethoprim-sulfamethoxazole induced rash and fatal hematologic disorders
    Zeliha Kocak
    Infectious Diseases and Clinical Microbiology Department, Ministry of Health Ankara Research and Training Hospital, Ankara, Turkey
    J Infect 52:e49-52. 2006
    ..We want to underline that although the TMP-SMX combination is usually well tolerated it can also lead to fatal complications...
  48. ncbi Routinely available cotrimoxazole prophylaxis and occurrence of respiratory and diarrhoeal morbidity in infants born to HIV-infected mothers in South Africa
    A Coutsoudis
    Department of Paediatrics and Child Health, University of KwaZulu Natal, Durban, South Africa
    S Afr Med J 95:339-45. 2005
    ..To examine the influence of cotrimoxazole (CTM) prophylaxis on incidence of lower respiratory tract infections (LRTIs) and diarrhoea...
  49. ncbi Comparison of the efficacy of two months of treatment with co-trimoxazole plus doxycycline vs. co-trimoxazole plus rifampin in brucellosis
    Mohammad Reza Hasanjani Roushan
    Department of Infectious Diseases, Yahyanejad Hospital, Babol Medical University, Iran
    Swiss Med Wkly 134:564-8. 2004
    ..To compare the efficacy of two different regimens in treatment of brucellosis...
  50. ncbi Cotrimoxazole prophylaxis and malaria in Africa: Have the important questions been answered?
    Miriam K Laufer
    Am J Trop Med Hyg 75:373-4. 2006
  51. ncbi Prophylaxis of opportunistic infections in HIV-infected adults in sub-Saharan Africa: opportunities and obstacles
    Veronique Bortolotti
    AIDS 16:1309-17. 2002
  52. ncbi Effect of co-trimoxazole prophylaxis, antiretroviral therapy, and insecticide-treated bednets on the frequency of malaria in HIV-1-infected adults in Uganda: a prospective cohort study
    Jonathan Mermin
    CDC Uganda, Global AIDS Program, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention CDC, Entebbe, Uganda
    Lancet 367:1256-61. 2006
    ....
  53. ncbi Mortality in HIV-infected Ugandan adults receiving antiretroviral treatment and survival of their HIV-uninfected children: a prospective cohort study
    Jonathan Mermin
    Centers for Disease Control and Prevention Uganda, Global AIDS Program, National Center for HIV, Viral Hepatitis, Sexually Transmitted Disease, and Tuberculosis Prevention, Centers for Disease Control and Prevention, Entebbe, Uganda
    Lancet 371:752-9. 2008
    ..We therefore assessed the effect of a home-based ART programme in Uganda on mortality, hospital admissions, and orphanhood in people with HIV-1 and their household members...
  54. ncbi Primary prevention with cotrimoxazole for HIV-1-infected adults: results of the pilot study in Dakar, Senegal
    M Maynart
    INSERM U88, Paris, France
    J Acquir Immune Defic Syndr 26:130-6. 2001
    ..To assess the efficacy and tolerance of chemoprophylaxis with cotrimoxazole compared with placebo among HIV-1-infected adults...
  55. ncbi High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda
    Anne F Gasasira
    Department of Internal Medicine, Makerere University, Mulago Hospital, Kampala, Uganda
    Clin Infect Dis 46:985-91. 2008
    ..Artemisinin-based combination therapies are rapidly being adopted for the treatment of malaria in Africa; however, there are limited data on their safety and efficacy among human immunodeficiency virus (HIV)-infected populations...
  56. ncbi The impact of daily cotrimoxazole prophylaxis and antiretroviral therapy on mortality and hospital admissions in HIV-infected Zambian children
    A Sarah Walker
    MRC Clinical Trials Unit, London, United Kingdom
    Clin Infect Dis 44:1361-7. 2007
    ..Data on the population effectiveness of cotrimoxazole prophylaxis and antiretroviral therapy (ART) in human immunodeficiency virus (HIV)-infected African children are few...
  57. ncbi Integrons and gene cassettes in clinical isolates of co-trimoxazole-resistant Gram-negative bacteria
    M Grape
    Microbiology and Tumor Biology Center MTC, Clinical Microbiology, Karolinska Institute, Karolinska Hospital L2 02, Stockholm SE 171 76, Sweden
    Clin Microbiol Infect 11:185-92. 2005
    ..Resistance to co-trimoxazole and many other antibiotics was thus not accounted for fully by the presence of integrons in these isolates...
  58. ncbi A randomized, pilot trial comparing full versus escalating dose regimens for the desensitization of AIDS patients allergic to sulfonamides
    Andrea Straatmann
    Federal University of Bahia, Infectology Foundation of Bahia, Salvador, BA, Brazil
    Braz J Infect Dis 6:276-80. 2002
    ..However, the use of sulfonamides is often associated with the development of allergic reactions, provoking the substitution of the drug (by another that may be less effective); alternatively attempts are made to desensitize the patient...
  59. ncbi Antibiotic combinations significantly more active than monotherapy in an in vitro infection model of Stenotrophomonas maltophilia
    Sheryl A Zelenitsky
    Faculty of Pharmacy, University of Manitoba, Winnepeg, MB, Canada R3T 2N2
    Diagn Microbiol Infect Dis 51:39-43. 2005
    ..These preclinical data support further investigation of antibiotic combinations in the management of serious S. maltophilia infections...
  60. ncbi Acquired sulphonamide resistance genes in faecal Escherichia coli from healthy children in Bolivia and Peru
    Beronica Infante
    Microbiology and Tumor Biology Centre MTC, Clinical Microbiology, Karolinska Institute, SE 17176 Stockholm, Sweden
    Int J Antimicrob Agents 25:308-12. 2005
    ..In conclusion, the high prevalence of sul-genes in this material of faecal commensal E. coli isolates points to a potential role of the faecal flora in the emergence and spread of antimicrobial resistance...
  61. ncbi Voluntary counselling, HIV testing and adjunctive cotrimoxazole reduces mortality in tuberculosis patients in Thyolo, Malawi
    Rony Zachariah
    Medecins Sans Frontieres Luxembourg, Blantyre, Malawi
    AIDS 17:1053-61. 2003
    ....
  62. ncbi Urinary tract infections and a multidrug-resistant Escherichia coli clonal group
    Elaine O Petrof
    N Engl J Med 346:535-6. 2002
  63. ncbi The impact of HIV infection and trimethoprim-sulphamethoxazole prophylaxis on bacterial isolates from children with community-acquired pneumonia in South Africa
    Heather J Zar
    School of Child and Adolescent Health, Red Cross War Memorial Children s Hospital, University of Cape Town, South Africa
    J Trop Pediatr 49:78-83. 2003
    ..17 of 79 (22 per cent), p = 0.009]. The rising prevalence of HIV infection and the use of TMP-SMX prophylaxis may alter the spectrum of colonizing and pathogenic bacteria in children in developing countries...
  64. ncbi Trimethoprim-sulfamethoxazole activity and pharmacodynamics against glycopeptide-intermediate Staphylococcus aureus
    Sandy J Close
    Infectious Disease Research Laboratory, College of Pharmacy, University of Toledo, Ohio 43606, USA
    Pharmacotherapy 22:983-9. 2002
    ..To determine the activity of trimethoprim-sulfamethoxazole (TMP-SMX) against glycopeptide-intermediate Staphylococcus aureus (GISA)...
  65. pmc Emergence of vancomycin-intermediate Staphylococcus aureus and S. sciuri, Greece
    Athanassios Tsakris
    Emerg Infect Dis 8:536-7. 2002
  66. ncbi Pneumocystis pneumonia
    F J L Robberts
    Department of Medical Microbiology, Tygerberg Hospital, University of Stellenbosch, PO Box 19063, Tygerberg, 7505
    SADJ 57:451-3. 2002
    ..Sulphonamide resistance has been reported elsewhere, and is due to point mutations at codons 55 and 57 of the dihydropteroate synthase gene. Strain typing is useful for molecular epidemiological purposes...
  67. pmc Reconsidering empirical cotrimoxazole prophylaxis for infants exposed to HIV infection
    Christopher J Gill
    Department of International Health, Center for International Health and Development, Boston University School of Public Health, Boston, MA, USA
    Bull World Health Organ 82:290-7. 2004
    ..From a critical analysis of the literature, we offer a conceptual model demonstrating how, under certain circumstances, a policy of mass cotrimoxazole prophylaxis may be counterproductive...
  68. ncbi Pneumocystis jiroveci pneumonia
    Andrew M Luks
    Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, Washington, USA
    Respir Care 52:59-63. 2007
  69. ncbi Does cotrimoxazole prophylaxis for the prevention of HIV-associated opportunistic infections select for resistant pathogens in Kenyan adults?
    Mary J Hamel
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Am J Trop Med Hyg 79:320-30. 2008
    ..005). Daily cotrimoxazole prevented malaria and reduced incidence of antifolate-resistant P. falciparum but contributed to increased pneumococcus and commensal Escherichia coli resistance...
  70. ncbi Antibiotics in older adults
    María C Rodríguez-Julbe
    Infectious Diseases Program, San Juan Veterans Affairs Medical Center and the Department of Medicine, University Hospital, Medical Sciences Campus, University of Puerto Rico, San Juan P R
    P R Health Sci J 23:25-33. 2004
    ..Other trimetroprin-sulfame-thoxazole, the newer macrolides (azithromycin and clarithromycin) as well as the aminoglycosides, vancomycin, clindamycin, metroridazole. The indications and contraindications are presented and reviewed...
  71. ncbi Increase in prevalence of Pneumocystis carinii mutations in patients with AIDS and P. carinii pneumonia, in the United States and China
    Powel H Kazanjian
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
    J Infect Dis 189:1684-7. 2004
    ..01). In China, 7% of patients had DHPS mutations; none received sulfa-drug prophylaxis. The prevalence of P. carinii DHPS mutations has markedly increased in the United States but remains low in China...
  72. pmc Detection of Pneumocystis carinii and characterization of mutations associated with sulfa resistance in bronchoalveolar lavage samples from human immunodeficiency virus-infected subjects
    Anna Zingale
    Infectious Diseases Division Clinical Molecular Biology, San Raffaele Scientific Institute, Milan, Italy
    J Clin Microbiol 41:2709-12. 2003
    ..Mutations were identified in 28 out of 70 (40%) PCR-positive specimens and were significantly more common in patients exposed to sulfa drugs (21 out of 29 [72.4%]) than in those not exposed to sulfa drugs (4 out of 35 [11.4%])...
  73. ncbi Empirical treatment of acute cystitis in women
    Lindsay E Nicolle
    Department of Internal Medicine, Health Sciences Centre, University of Manitoba, 820 Sherbrook Street, Room GG443, Winnipeg, Manitoba, Canada R3A 1R9
    Int J Antimicrob Agents 22:1-6. 2003
    ..Fosfomycin trometamol as a single dose has cure rates of 75-85%. All these agents are effective, but a compromise in efficacy or duration of therapy compared with current 3-day regimens may have to be considered...
  74. ncbi Multistate evaluation of invasive pneumococcal diseases in adults with human immunodeficiency virus infection: serotype and antimicrobial resistance patterns in the United States
    A M Fry
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 188:643-52. 2003
    ..HIV/AIDS was not an independent risk factor for TMP-SMZ nonsusceptibility. Vulnerability to certain serotypes among adults with HIV/AIDS may have implications in prevention strategies...
  75. ncbi Recurrence of Pneumocystis carinii pneumonia in an HIV-infected patient: apparent selective immune reconstitution after initiation of antiretroviral therapy
    K Crothers
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA
    HIV Med 4:346-9. 2003
    ....
  76. ncbi First report of pulmonary Nocardia otitidiscaviarum infection in an immunocompetent patient from Turkey
    O Dikensoy
    Department of Pulmonary Disease, School of Medicine, Gaziantep University, Gaziantep, Turkey
    Int J Clin Pract 58:210-3. 2004
    ..This is the first report of pulmonary N. otitidiscaviarum infection in an immune-competent patient from Turkey...
  77. ncbi Comparison of dio-bacit, bacitracin-trimethoprim/ sulphamethoxazole and latex agglutination in the diagnosis of Group A beta-hemolytic streptococci
    Mustafa Altindis
    Department of Microbiology and Clinical Microbiology, Kocatepe University Faculty of Medicine, Afyon, Turkey
    Yonsei Med J 45:56-60. 2004
    ..0% and 96.9%, respectively. Dio-Bacit plates provide an easy and very useful way to identify GAS within one day, saving time, labor, and money for routine diagnostic microbiology laboratories...
  78. pmc Cotrimoxazole prophylaxis for infants exposed to HIV infection
    Stephen M Graham
    Department of Paediatrics, College of Medicine University of Malawi
    Bull World Health Organ 82:297-8. 2004
  79. ncbi Febrile urinary tract infection in children: ampicillin and trimethoprim insufficient as empirical mono-therapy
    Martina Prelog
    Department of Pediatrics, Innsbruck Medical University, Innsbruck, Austria
    Pediatr Nephrol 23:597-602. 2008
    ..coli cultures from patients with VUR (37.8%) than from those without VUR (25.8%). Treatment with TMP, SXT and AMP alone appeared to be insufficient in many cases because of high resistance rates of E. coli and other uropathogens...
  80. ncbi Study of clinical profile and antibiotic response in typhoid fever
    M N Chowta
    Department of Medicine, Kasturba Medical College, Mangalore 575 002, India
    Indian J Med Microbiol 23:125-7. 2005
    ..Indiscriminate use of drugs in typhoid fever should be discouraged. Appropriate antibiotic as indicated by sensitivity tests should be employed to prevent the development of resistant strains of S. typhi...
  81. ncbi [A clinical analysis of 22 cases of Pneumocystis pneumonia in acquired immunodeficiency syndrome]
    Huan Ling Wang
    Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
    Zhonghua Nei Ke Za Zhi 44:652-5. 2005
    ..To investigate the clinical characteristics, therapeutical approaches and outcome of Pneumocystis pneumonia (PCP) in patients with AIDS...
  82. ncbi Predictive biomarkers for drug-resistant Acinetobacter baumannii isolates with bla(TEM-1), AmpC-type bla and integrase 1 genotypes
    Chang Hua Chen
    Division of Infectious Diseases, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan
    J Microbiol Immunol Infect 39:372-9. 2006
    ..We tested whether antibiotic susceptibilities of drug-resistant Acinetobacter baumannii isolates could be used to predict the clinically important genotypes bla(TEM-1), AmpC-type bla, and integrase 1 gene (IntI1)...
  83. ncbi Cervicofacial nocardiosis in an immunocompetent child
    T Sathish Kumar
    Department of Child Health Unit II, Christian Medical College, Vellore, India
    Acta Paediatr 94:1342-3. 2005
    ..This child did not have any predisposing risk factors for this infection and responded well to treatment with co-trimoxazole and chloramphenicol. She is doing well on follow-up...
  84. ncbi Effectiveness and cost effectiveness of early and late prevention of HIV/AIDS progression with antiretrovirals or antibiotics in Southern African adults
    M O Bachmann
    School of Medicine, University of East Anglia, UK
    AIDS Care 18:109-20. 2006
    ..Cost-effectiveness estimates were sensitive to discounting and assumed treatment costs but were less sensitive to assumed treatment effectiveness...
  85. ncbi Oral trimethoprim-sulphamethoxazole levels in stable HIV-infected children
    Heather J Zar
    School of Child and Adolescent Health, Red Cross War Memorial Children s Hospital, Cape Town
    S Afr Med J 96:627-9. 2006
    ..However, oral therapy is desirable as the intravenous route is costly, time-consuming, more difficult to administer and carries a risk of needlestick injury...
  86. ncbi Phylogenetic background and carriage of pathogenicity island-like domains in relation to antibiotic resistance profiles among Escherichia coli urosepsis isolates
    Véronique Houdouin
    Laboratoire d études de génétique bactérienne dans les infections de l enfant EA3105, Université Denis Diderot Paris 7 AP HP, Hopital Robert Debre, Service de Microbiologie, 75019 Paris, France
    J Antimicrob Chemother 58:748-51. 2006
    ..Nalidixic acid resistance was associated with a lower prevalence of sfa/foc, K1 antigen, pathogenicity island II(J96)-like domains, subgroup B2/I and a shift towards group A...
  87. ncbi Disclosure of HIV status and adherence to daily drug regimens among HIV-infected children in Uganda
    Winnie Bikaako-Kajura
    CDC Uganda, Global AIDS Program, Kampala, Uganda
    AIDS Behav 10:S85-93. 2006
    ....
  88. ncbi Discontinuation of secondary prophylaxis for Pneumocystis pneumonia in human immunodeficiency virus-infected children treated with highly active antiretroviral therapy
    Susanna Esposito
    Institute of Pediatrics, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, University of Milan, Milan, Italy
    Pediatr Infect Dis J 24:1117-20. 2005
    ....
  89. pmc Antimicrobial susceptibility of invasive Streptococcus pneumoniae isolates in Portugal over an 11-year period
    Ricardo Dias
    Antibiotic Resistance Unit, Centre of Bacteriology, National Institute of Health Dr Ricardo Jorge, Lisbon, Portugal
    Antimicrob Agents Chemother 50:2098-105. 2006
    ..The use of penicillin to treat empirical invasive pneumococci infections may need to be reconsidered...
  90. pmc Open-label randomized trial of oral trimethoprim-sulfamethoxazole, doxycycline, and chloramphenicol compared with trimethoprim-sulfamethoxazole and doxycycline for maintenance therapy of melioidosis
    Wipada Chaowagul
    Medical Department, Sappasithiprasong Hospital, Ubon Ratchathani, Thailand
    Antimicrob Agents Chemother 49:4020-5. 2005
    ..7-fold increase of relapse or death. A combination of TMP-SMX and doxycycline is as effective as and better tolerated than the conventional four-drug regimen for the oral treatment phase of melioidosis...
  91. ncbi A community-based study of the incidence of trimethoprim-sulfamethoxazole-preventable infections in Malawian adults living with HIV
    Joep J G van Oosterhout
    Department of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi
    J Acquir Immune Defic Syndr 39:626-31. 2005
    ..These should also assess benefit in patients receiving antiretroviral therapy...
  92. ncbi A background and critical analysis of the treatment of pneumocystis carinii pneumonia (PCP) in HIV/AIDS
    Brett Mitchell
    North Glamorgan NHS Trust, United Kingdom
    Aust Nurs J 14:20-3. 2007
  93. ncbi Cases from the Osler Medical Service at Johns Hopkins University. Diagnosis: P. carinii pneumonia and primary pulmonary sporotrichosis
    Julie Aurore Losman
    Am J Med 117:353-6. 2004
    ..Induced sputum was negative for Pneumocystis carinii, fungi, or acid-fast bacilli. A bronchoalveolar lavage was performed. What is the diagnosis?..
  94. ncbi [Treatment of a septic shock due to multiresistant Acinetobacter baumannii with tigecycline in combination]
    T Leclerc
    Service d Anesthesie Reanimation, HIA Percy, 101, avenue H Barbusse, 92141 Clamart Cedex, France
    Ann Fr Anesth Reanim 26:1056-8. 2007
    ..This case shows that combined antimicrobial therapy including tigecycline can be relevant in some severe pulmonary infections due to multiresistant A. baumannii...
  95. ncbi [The use of sulfonamides and sulfonamide/trimethoprim combinations as animal feed drugs for pigs in Schleswig-Holstein]
    Susanne Broll
    WHO Collaborating Centre for Research and Training in Veterinary Public Health an der Tierärztlichen Hochschule Hannover
    Berl Munch Tierarztl Wochenschr 117:392-7. 2004
    ..There were large deviations to the rules of good clinical practise for the use of antibiotics. The applied dosage was often lower than suggested in the literature...
  96. ncbi Household contacts were key factor for children's colonization with resistant Escherichia coli in community setting
    Susanne Lietzau
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    J Clin Epidemiol 60:1149-55. 2007
    ..coli) can lead to life-threatening situations. Epidemiological data on the prevalence and major determinants of carriage of antibiotic resistant E. coli among children in the community setting are sparse...
  97. ncbi Elimination of a community-acquired methicillin-resistant Staphylococcus aureus infection in a nurse with atopic dermatitis
    Alexander Roesch
    Department of Dermatology, University of Regensburg, Franz Josef Strauss Allee 11, D 91053 Regensburg, Germany
    Arch Dermatol 141:1520-2. 2005
  98. pmc The independent effect of highly active antiretroviral therapy on severe opportunistic disease incidence and mortality in HIV-infected adults in Côte d'Ivoire
    Elena Losina
    Department of Biostatistics and Epidemiology, Boston University School of Public Health, Boston, MA, USA
    Antivir Ther 12:543-51. 2007
    ..Studies in developed countries have shown highly active antiretroviral therapy (HAART) decreases incidence of severe opportunistic diseases (ODs) in HIV-infected patients beyond that which is expected from changes in CD4+ T-cell count...
  99. ncbi Pneumocystis carinii pneumonia in Hong Kong: a 10 year retrospective study
    M Hui
    Department of Microbiology, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR
    J Med Microbiol 55:85-8. 2006
    ..The mortality of PCP was high despite appropriate treatment. Chemoprophylaxis should be considered in populations at risk...
  100. ncbi Inhibition of bacterial adhesion by subinhibitory concentrations of antibiotics
    K C Vidya
    Department of Microbiology, Kasturba Medical College, Manipal, India
    Indian J Med Microbiol 23:102-5. 2005
    ..coli is adhesion. There is accumulating evidence that through subinhibitory concentrations (sub-MICs) of many antibiotics do not kill bacteria, they are able to interfere with some important aspects of bacterial cell function...
  101. ncbi Antimicrobial resistance patterns of Campylobacter from feedlot cattle*
    M D Englen
    USDA ARS, Bacterial Epidemiology and Antimicrobial Resistance Research Unit, Richard B Russell Agricultural Research Center, Athens, GA 30605 2720, USA
    J Appl Microbiol 99:285-91. 2005
    ..This study examined 448 Campylobacter strains isolated in 1999 and 2000 from US feedlot cattle for resistance to 12 antimicrobials...

Research Grants62

  1. Molecular Basis of E. coli Adhesins in Bladder Disorders
    Scott J Hultgren; Fiscal Year: 2013
    ....
  2. Membrane Protein Trafficking in Photoreceptors
    Wolfgang Baehr; Fiscal Year: 2013
    ..Transport of membrane proteins, particularly post-Golgi transport and intraflagellar transport through the cilium, are complex and insufficiently understood in disease etiology. ..
  3. Pneumocystis jirovecii Targeted Antiopportunistic Agents
    Aleem Gangjee; Fiscal Year: 2013
    ..jirovecii) rather than a surrogate (P. carinii). The study should identify potential compounds for clinical evaluation against PCP and resistant PCP to be used alone or in combination. ..
  4. An Integrated Diagnostic System for Rapid Antimicrobial Susceptibility Testing
    VINCENT JEN JR GAU; Fiscal Year: 2013
    ..A separate Milestones and Timeline section is included at the end of the Research Strategy. ..
  5. Patient-Oriented Research and Mentoring in Pneumocystis
    Laurence Huang; Fiscal Year: 2010
    ..The development of rapid, non-invasive tests that can diagnosis PCP and TB effectively would be significant advances. ..
  6. HIV Testing and Educating Male Partners to Improve Maternal and Infant Outcomes
    Carey Farquhar; Fiscal Year: 2013
    ....
  7. Epidemic CA-MRSA: Molecular Epidemiology and Immunology
    Robert S Daum; Fiscal Year: 2013
    ..It is hoped that new information will guide novel therapeutic and preventive strategies to combat CA-MRSA infection. ..
  8. Cranberry: Interactions with Anti-infectious Agents
    Gail Anderson; Fiscal Year: 2005
    ..abstract_text> ..
  9. Mechanisms of risk for sulfoniamide hypersensitivity
    Lauren A Trepanier; Fiscal Year: 2013
    ..The ultimate goal is to improve the safety of this inexpensive antimicrobial for both the general population and for HIV-infected patients. ..
  10. Differences in infecting and colonizing Enterobacteriaceae from short-course vs s
    Scott J Weissman; Fiscal Year: 2013
    ..coli or K. pneumoniae, these findings would make a significant impact on prescribing behavior, toward reducing pediatric antibiotic exposure and thus the selection for resistance. ..
  11. Small molecule inhibitors of bacterial iron acquisition systems
    Harry L Mobley; Fiscal Year: 2013
    ..This knowledge will provide us with alternate therapeutic agents beyond existing antibiotics and potential vaccines to prevent this public health scourge in women with recurrent UTI and those susceptible to their first UTI. ..
  12. Membrane-targeting calcium sensors in vision
    James B Ames; Fiscal Year: 2013
    ..4) at the rod synapse to understand the Ca2+-dependent regulatory mechanism of ion channels linked to retinal diseases. ..
  13. Clinical trial of trimethoprim-sulfamethoxazole or chloroquine in adults on ART
    Miriam K Laufer; Fiscal Year: 2013
    ....
  14. Effects of Daily Cotrimoxazole on Malaria in HIV Exposed, Uninfected Infants
    JONATHAN JAMES JULIANO; Fiscal Year: 2013
    ..This research will add to the limited body of evidence on CPT in HIV-exposed uninfected infants, and will have direct implications for Malawi's national well-child, malaria, and HIV programs. ..
  15. MPS1 kinase in the Spindle Pole Cycle
    Mark Winey; Fiscal Year: 2013
    ..In summary, our completed yeast SPB phosphoproteome allows us to move beyond the mapping of specific phosphorylation sites to the more complex questions of how phospho-regulation acts in centrosome assembly, structure and function. ..
  16. "Studies to examine Centrin's role in DNA repair"
    Kiran Madura; Fiscal Year: 2010
    ..However, the function of Rad4 is not well understood, and its characterization is the focus of this application. ..
  17. Tetrahymena Basal Body Duplication
    Mark Winey; Fiscal Year: 2013
    ..The proposed research program will elucidate key components and mechanisms for the early stages of basal body and centriole assembly, and for exchange of proteins that may contribute to maintaining the integrity of these structures. ..
  18. The role of Centrins 1 and 2 at Tetrahymena thermophila basal bodies.
    Tyson Vonderfecht; Fiscal Year: 2012
    ..The studies described here will add to our understanding of the molecular pathways for basal body assembly and will significantly contribute to our knowledge of this important, basic biological structure. ..
  19. Short Breastfeeding and Cotrimoxazole among HIV-Exposed Infants in Botswana
    Roger L Shapiro; Fiscal Year: 2013
    ..HAART and CTX will be available from the Botswana Government for all qualifying HIV-infected women and infants. ..
  20. RIVUR Study
    Tej K Mattoo; Fiscal Year: 2012
    ..abstract_text> ..
  21. TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2003
    ....
  22. Improving Drug Adherence Among Adolescents in Uganda using SMS Reminders
    Sebastian Linnemayr; Fiscal Year: 2013
    ..The third aim is to synthesize lessons learned and discuss them with the clinics and other key stakeholders. A cost-effectiveness analysis of one- versus two-way messages will also be performed as part of this aim. ..
  23. Randomized Intervention for Vesico-Ureteral Reflux (RIVUR) Trial
    Ming Hsien Wang; Fiscal Year: 2012
    ..As of October 2009, 370 children have been recruited into the study and are being followed for 2 years. The primary aim of the extension is to complete recruitment and follow-up of the study cohort. ..
  24. IMPACT OF TS PROPHYLAXIS ON ANTIFOLATE RESISTANT MALARIA
    James Kublin; Fiscal Year: 2000
    ..At the end of the training period Dr. Kublin will be well-positioned to develop an independent research program in international health. ..
  25. Pharmacogenetics of sulfamethoxazole in HIV/AIDS patients
    Danxin Wang; Fiscal Year: 2009
    ....
  26. CENTROSOME DEFECTS AS CAUSES OF MALE INFERTILITY
    Gerald Schatten; Fiscal Year: 1999
    ....
  27. Novel, P. jirovecii Specific Antipneumocystis Agents
    Aleem Gangjee; Fiscal Year: 2009
    ..These agents could be used alone or in combination to treat PCP thus providing novel agents against a new target. ..
  28. TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  29. REACTIONS TO TRIMETHOPRIM-SULFAMETHOXAZOLE IN AIDS
    Manuel Lopez; Fiscal Year: 1990
    ..In addition, the results will provide a better understanding of altered immune responses in AIDS patients...
  30. METABOLIC BASIS OF SULFONAMIDE TOXICITY IN AIDS PATIENTS
    CRAIG SVENSSON; Fiscal Year: 1999
    ..The hypothesis that the association between in vitro cytotoxicity and in vivo hypersensitivity is due to the development of neoantigens which, in turn, elicit an immune response will be tested. ..
  31. S-Adenosylmethionine and Pneumocystis treatment
    Salim Merali; Fiscal Year: 2009
    ..Completion of these Aims will lay the groundwork for developing the nicotine or nicotine analogues as sole or adjunctive therapy for PCP. ..
  32. PNEUMOCYSTIS CARINII IN CONTINOUS AXENIC CULTURE
    ALLEN CLARKSON JR; Fiscal Year: 2001
    ..An attempt will be made to correlate drug sensitivity, gene sequence and patient response to determine if there is resistance to this drug combination in human P. carinii. ..
  33. CHITIN SYNTHESIS IN PNEUMOCYSTIS
    Michael Horst; Fiscal Year: 1990
    ..From a diagnostic point of view, there are no definitive histochemical or immunostaining tests for chitin. Thus, a fast, sensitive method for detection of P. carinii infections may prove useful in the diagnosis of the disease...
  34. Institutional Collaboration Between Liverpool STM & CDC on Malaria
    Feiko ter Kuile; Fiscal Year: 2009
    ..The secretariat will be based at the LSTM. ..
  35. Rebound Malaria Following Trimethoprim-Sulfamethoxazole Prophylaxis in Children
    Taylor Sandison; Fiscal Year: 2010
    ..This study will help clarify the full effect of TS prophylaxis in HIV-exposed children and the implications of mass chemoprophylaxis. ..
  36. MARROW SUPPRESSION FROM A LENTIVIRUS
    JANIS ABKOWITZ; Fiscal Year: 1993
    ..In addition, as FTLV does not infect human cells or cell lines, these studies involve less biohazard than cell culture studies with blood or marrow from AIDS patients...
  37. GENETICS OF CENTRIN AND THE SPINDLE POLE BODY IN YEAST
    Mark Rose; Fiscal Year: 2003
    ..The MTOC proteins identified here may be important targets for anti-mitotic drugs for the treatment of cancer and fungal infections. ..
  38. BIOLOGY AND TREATMENT OF AIDS LYMPHOMAS
    Richard Fisher; Fiscal Year: 1993
    ....
  39. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    KATHLEEN GALINDO; Fiscal Year: 2006
    ..An EMS mutagenesis screen will be performed to attain mutations in Centrin genes in vivo. Defining the functions of Centrosomin and Centrin will contribute to our understanding of centrosome function. ..
  40. MASS SPECTROMETER FOR BIOMEDICAL RESEARCH
    Michael Gross; Fiscal Year: 2007
    ..In addition, it will have broad impact by providing nationwide mass spectrometry service for researchers whose MS requirements are sufficiently simple that they do not require collaborative efforts. [unreadable] [unreadable] [unreadable]..
  41. Randomized, controlled trial of daily trimethoprim-sulfamethoxazole or weekly chl
    CHRISTOPHER PLOWE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  42. Resistant E.coli in Humans and Poultry
    James Johnson; Fiscal Year: 2005
    ..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
  43. MULTIDISCIPLINARY BASIC RESEARCH TRAINING IN CANCER
    JEFFREY SALISBURY; Fiscal Year: 2002
    ..Separate facilities are available for animal housing, engineering, and classroom and lecture space. ..
  44. Centrosome Amplification in Human Breast Cancer
    JEFFREY SALISBURY; Fiscal Year: 2006
    ..The study of centrosome behavior is of fundamental importance to our understanding of the origin of malignant tumors and may reveal new targets for intervention or prevention of the development of breast cancer. ..
  45. co-Trimoxazole in Zambian Infants (TZI)
    CHRISTOPHER GILL; Fiscal Year: 2007
    ..abstract_text> ..
  46. Eighth International Workshops on Opportunistic Protists
    Melanie Cushion; Fiscal Year: 2003
    ..Mead's and Cushion's ancestors include native Americans; Marciano-Cabral is Hispanic; Kaneshiro has Pacific-Asian ancestry; Lindsay, Weiss are white. Lindsay is a physically handicapped individual. ..
  47. New Approaches for Development of PcP Therapy
    Melanie Cushion; Fiscal Year: 2006
    ..Finally, they will select the most efficacious combinations of agents and evaluate their effects on gene expression again using the macroarray approach. ..
  48. PNEUMOCYSTIS GENOME PROJECT
    Melanie Cushion; Fiscal Year: 2004
    ..Thus, there is but a single aim to this proposal: 1. To finish sequencing the genome of pneumocystis carinii and provide a completed assembly. ..
  49. Molecular Epidemiology of Human P. carinii Pneumonia
    Laurence Huang; Fiscal Year: 2006
    ..abstract_text> ..
  50. TRANSMISSION OF PNEUMOCYSTIS INFECTION
    Melanie Cushion; Fiscal Year: 2001
    ..These studies will result in a clearer understanding of the biology leading to infection with Pc and will provide a rational basis for clinical management and therapeutic intervention. ..
  51. Cranberry and Prevention of UTI A Comprehensive Approach
    Kalpana Gupta; Fiscal Year: 2007
    ....
  52. H2O2-PRODUCING LACTOBACILLI AND POSTMENOPAUSAL UTI
    Kalpana Gupta; Fiscal Year: 2005
    ....
  53. Chronic Prostatitis Collaborative Research Network CPCRN
    J Nickel; Fiscal Year: 2007
    ..Nickel as PI has the experience, expertise and the proven ability to design, implement and enroll patients with CPPS in clinical studies and will be a valuable partner in the proposed CPCRN and UCPPSCG. ..
  54. Genomic Instability and Etiology of Estrogen Oncogenesis
    Jonathan Li; Fiscal Year: 2007
    ..abstract_text> ..
  55. Novel Methods to Access Brain Function in HIV-1
    Christina Marra; Fiscal Year: 2003
    ..abstract_text> ..
  56. IMPDH as a Drug Target in Cryptosporidium
    Boris Striepen; Fiscal Year: 2008
    ..This work will provide urgently needed molecular reagents to understand the biology of nutrient uptake and drug resistance in this unique parasite. [unreadable] [unreadable] [unreadable]..
  57. RESPIRATORY DISEASES/BSI STUDY
    Shahin Lockman; Fiscal Year: 2004
    ....
  58. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Saiman; Fiscal Year: 2009
    ..Carefully conducted observational studies and clinically relevant in vitro antimicrobial susceptibility testing, hold the greatest promise to improve the treatment of patients infected with mutidrug-resistant organisms. ..