thiamine

Summary

Summary: 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.

Top Publications

  1. ncbi nmt1 of fission yeast. A highly transcribed gene completely repressed by thiamine
    K Maundrell
    Sclavo Research Centre, Siena, Italy
    J Biol Chem 265:10857-64. 1990
  2. ncbi Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetes
    N Karachalias
    Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex, UK
    Diabetologia 53:1506-16. 2010
  3. pmc Vitamin B1 functions as an activator of plant disease resistance
    Il Pyung Ahn
    School of Agricultural Biotechnology and Center for Agricultural Biomaterials, Seoul National University, Seoul 151 742, Korea
    Plant Physiol 138:1505-15. 2005
  4. pmc Genome-wide association analysis identifies a mutation in the thiamine transporter 2 (SLC19A3) gene associated with Alaskan Husky encephalopathy
    Karen M Vernau
    University of California Davis, Davis, California, United States of America
    PLoS ONE 8:e57195. 2013
  5. ncbi The potential role of thiamine (vitamin B1) in diabetic complications
    Paul J Thornalley
    Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex CO4 3SQ, United Kingdom
    Curr Diabetes Rev 1:287-98. 2005
  6. ncbi Thiamine in plants: aspects of its metabolism and functions
    Aymeric Goyer
    Department of Botany and Plant Pathology, Oregon State University, Hermiston, OR 97838, USA
    Phytochemistry 71:1615-24. 2010
  7. ncbi Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study
    H Stracke
    Medical Clinic und Policlinic III, University Hospital Giessen and Marburg, Location Giessen, Germany
    Exp Clin Endocrinol Diabetes 116:600-5. 2008
  8. ncbi Antioxidant properties of thiamine
    P I Lukienko
    Laboratory of Biochemical Pharmacology, Institute of Biochemistry, Belarussian Academy of Sciences, Minsk
    Bull Exp Biol Med 130:874-6. 2000
  9. pmc Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase
    Abhishek Chatterjee
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
    Nature 478:542-6. 2011
  10. pmc Thiamine status in humans and content of phosphorylated thiamine derivatives in biopsies and cultured cells
    Marjorie Gangolf
    GIGA Neurosciences, University of Liege, Liege, Belgium
    PLoS ONE 5:e13616. 2010

Research Grants

Detail Information

Publications363 found, 100 shown here

  1. ncbi nmt1 of fission yeast. A highly transcribed gene completely repressed by thiamine
    K Maundrell
    Sclavo Research Centre, Siena, Italy
    J Biol Chem 265:10857-64. 1990
    ..By contrast, in minimal medium supplemented with thiamine at a concentration of 0.5 microM or greater the transcript is undetectable...
  2. ncbi Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetes
    N Karachalias
    Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex, UK
    Diabetologia 53:1506-16. 2010
    The aim of this study was to quantify protein damage by glycation, oxidation and nitration in a rat model of diabetes at the sites of development of microvascular complications, including the effects of thiamine and benfotiamine therapy.
  3. pmc Vitamin B1 functions as an activator of plant disease resistance
    Il Pyung Ahn
    School of Agricultural Biotechnology and Center for Agricultural Biomaterials, Seoul National University, Seoul 151 742, Korea
    Plant Physiol 138:1505-15. 2005
    Vitamin B(1) (thiamine) is an essential nutrient for humans. Vitamin B(1) deficiency causes beriberi, which disturbs the central nervous and circulatory systems...
  4. pmc Genome-wide association analysis identifies a mutation in the thiamine transporter 2 (SLC19A3) gene associated with Alaskan Husky encephalopathy
    Karen M Vernau
    University of California Davis, Davis, California, United States of America
    PLoS ONE 8:e57195. 2013
    ..SLC19A3 was identified as a positional candidate gene. This gene controls the uptake of thiamine in the CNS via expression of the thiamine transporter protein THTR2...
  5. ncbi The potential role of thiamine (vitamin B1) in diabetic complications
    Paul J Thornalley
    Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex CO4 3SQ, United Kingdom
    Curr Diabetes Rev 1:287-98. 2005
    ..This pathway is impaired in experimental and clinical diabetes by mild thiamine deficiency...
  6. ncbi Thiamine in plants: aspects of its metabolism and functions
    Aymeric Goyer
    Department of Botany and Plant Pathology, Oregon State University, Hermiston, OR 97838, USA
    Phytochemistry 71:1615-24. 2010
    b>Thiamine diphosphate (vitamin B(1)) plays a fundamental role as an enzymatic cofactor in universal metabolic pathways including glycolysis, the pentose phosphate pathway, and the tricarboxylic acid cycle...
  7. ncbi Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study
    H Stracke
    Medical Clinic und Policlinic III, University Hospital Giessen and Marburg, Location Giessen, Germany
    Exp Clin Endocrinol Diabetes 116:600-5. 2008
    ..Efficacy and safety of benfotiamine in treatment of diabetic polyneuropathy...
  8. ncbi Antioxidant properties of thiamine
    P I Lukienko
    Laboratory of Biochemical Pharmacology, Institute of Biochemistry, Belarussian Academy of Sciences, Minsk
    Bull Exp Biol Med 130:874-6. 2000
    b>Thiamine (10(-4)-10(-6)M) inhibits lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro. Thiamine interacts with free radicals and hydroperoxides and is oxidized to thiochrome and thiamine disulfide...
  9. pmc Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase
    Abhishek Chatterjee
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
    Nature 478:542-6. 2011
    b>Thiamine pyrophosphate 1 is an essential cofactor in all living systems. Its biosynthesis involves the separate syntheses of the pyrimidine 2 and thiazole 3 precursors, which are then coupled...
  10. pmc Thiamine status in humans and content of phosphorylated thiamine derivatives in biopsies and cultured cells
    Marjorie Gangolf
    GIGA Neurosciences, University of Liege, Liege, Belgium
    PLoS ONE 5:e13616. 2010
    b>Thiamine (vitamin B1) is an essential molecule for all life forms because thiamine diphosphate (ThDP) is an indispensable cofactor for oxidative energy metabolism...
  11. pmc Vitamin B1-induced priming is dependent on hydrogen peroxide and the NPR1 gene in Arabidopsis
    Il Pyung Ahn
    National Institute of Agricultural Biotechnology, Suwon 441 100, Korea
    Plant Physiol 143:838-48. 2007
    b>Thiamine confers systemic acquired resistance (SAR) on susceptible plants through priming, leading to rapid counterattack against pathogen invasion and perturbation of disease progress...
  12. pmc Molecular characterization of the thi3 gene involved in thiamine biosynthesis in Zea mays: cDNA sequence and enzymatic and structural properties of the recombinant bifunctional protein with 4-amino-5-hydroxymethyl-2-methylpyrimidine (phosphate) kinase and
    Maria Rapala-Kozik
    Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Biochem J 408:149-59. 2007
    A thiamine biosynthesis gene, thi3, from maize Zea mays has been identified through cloning and sequencing of cDNA and heterologous overexpression of the encoded protein, THI3, in Escherichia coli...
  13. ncbi Postpartum thiamine deficiency in a Karen displaced population
    R McGready
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Am J Clin Nutr 74:808-13. 2001
    ..OBJECTIVE: This study aimed to document thiamine status in the peripartum period to examine the current supplementation program and the correlation between the ..
  14. ncbi Outbreak of beriberi in a prison in Côte d'Ivoire
    Laurence Ahoua
    Epicentre, 42 boulevard Richard Lenoir, Paris 75011, France
    Food Nutr Bull 28:283-90. 2007
    ..A beriberi outbreak occurred in the Maison d'Arrêt et de Correction d'Abidjan (MACA), a detention center in Abidjan, Côte d'Ivoire, between October 2002 and April 2003...
  15. pmc Thiamin confers enhanced tolerance to oxidative stress in Arabidopsis
    Meral Tunc-Ozdemir
    Department of Biochemistry and Molecular Biology, University of Nevada, Reno, Nevada 89557, USA
    Plant Physiol 151:421-32. 2009
    ..Taken together, our studies suggest that thiamin and TPP function as important stress-response molecules that alleviate oxidative stress during different abiotic stress conditions...
  16. pmc Thiamine biosynthesis in algae is regulated by riboswitches
    Martin T Croft
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, United Kingdom
    Proc Natl Acad Sci U S A 104:20770-5. 2007
    In bacteria, many genes involved in the biosynthesis of cofactors such as thiamine pyrophosphate (TPP) are regulated by ribo switches, regions in the 5' end of mRNAs to which the cofactor binds, thereby affecting translation and/or ..
  17. pmc High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease
    P J Thornalley
    Department of Biological Sciences, University of Essex, Colchester, Essex, UK
    Diabetologia 50:2164-70. 2007
    To assess thiamine status by analysis of plasma, erythrocytes and urine in type 1 and type 2 diabetic patients and links to markers of vascular dysfunction.
  18. ncbi The structural and biochemical foundations of thiamin biosynthesis
    Christopher T Jurgenson
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Annu Rev Biochem 78:569-603. 2009
    ..Thiamin can also be transported into the cell and can be salvaged through several routes. In addition, two thiamin degrading enzymes have been characterized, one of which is linked to a novel salvage pathway...
  19. ncbi Thiamin diphosphate in biological chemistry: new aspects of thiamin metabolism, especially triphosphate derivatives acting other than as cofactors
    Lucien Bettendorff
    GIGA Neurosciences, University of Liege, Belgium
    FEBS J 276:2917-25. 2009
    ..coli, but the mechanism of ThTP synthesis remains elusive. The data reviewed here illustrate the complexity of thiamin biochemistry, which is not restricted to the cofactor role of ThDP...
  20. pmc A putative thiamine transport protein is a receptor for feline leukemia virus subgroup A
    Ramon Mendoza
    Program in Molecular and Cellular Biology, University of Washington, Seattle, USA
    J Virol 80:3378-85. 2006
    ..The feline cDNA shares approximately 93% amino acid sequence identity with the human thiamine transport protein 1 (THTR1)...
  21. ncbi Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression
    Wade Winkler
    Department of Molecular, Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, Connecticut 06520 8103, USA
    Nature 419:952-6. 2002
    ..We report here that mRNAs encoding enzymes involved in thiamine (vitamin B(1)) biosynthesis in Escherichia coli can bind thiamine or its pyrophosphate derivative without the ..
  22. pmc Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily
    Abhishek Chatterjee
    Department of Chemistry and Chemical Biology, 120 Baker Laboratory, Cornell University, Ithaca, New York 14853 1301, USA
    Nat Chem Biol 4:758-65. 2008
    ..a complex rearrangement of 5-aminoimidazole ribonucleotide (AIR) to form HMP-P, the pyrimidine moiety of thiamine phosphate...
  23. ncbi Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitro
    Ursula Schmid
    Institute of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    Diabetes Metab Res Rev 24:371-7. 2008
    ..Owing to a reduced activity of the enzyme transketolase, which requires diphosphorylated thiamine (vitamin B(1)) as cofactor, an accumulation of those deleterious glucose metabolites especially in diabetic ..
  24. ncbi Dietary and socio-economic factors associated with beriberi in breastfed Lao infants
    Douangdao Soukaloun
    Department of Pediatrics, Mahosot Hospital, Vientiane, Lao PDR
    Ann Trop Paediatr 23:181-6. 2003
    ..signs of sepsis, hypovolaemia or cardiac abnormalities, with rapid clinical improvement following parenteral thiamine. Subjects were matched by age and diet to 43 breast-feeding healthy control infants...
  25. ncbi Thiamine pyrophosphate: an essential cofactor for the alpha-oxidation in mammals--implications for thiamine deficiencies?
    M Sniekers
    Departement Moleculaire Celbiologie, Afdeling Farmacologie, Faculteit Geneeskunde, Katholieke Universiteit Leuven, O and N1, Herestraat 49, Box 601, 3000, Leuven, Belgium
    Cell Mol Life Sci 63:1553-63. 2006
    The identification of 2-hydroxyphytanoyl-CoA lyase (2-HPCL), a thiamine pyrophosphate (TPP)-dependent peroxisomal enzyme involved in the alpha-oxidation of phytanic acid and of 2-hydroxy straight chain fatty acids, pointed towards a role ..
  26. ncbi Thiamine-responsive megaloblastic anemia syndrome: a disorder of high-affinity thiamine transport
    E J Neufeld
    Division of Hematology, Children s Hospital, Boston, Massachusetts 02115, USA
    Blood Cells Mol Dis 27:135-8. 2001
    b>Thiamine-responsive megaloblastic anemia (TRMA) syndrome (OMIM No. 249270) comprises a distinctive triad of clinical features: megaloblastic anemia with ringed sideroblasts, diabetes mellitus, and progressive sensorineural deafness...
  27. ncbi Effects of high glucose and thiamine on the balance between matrix metalloproteinases and their tissue inhibitors in vascular cells
    Sonia Tarallo
    Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy
    Acta Diabetol 47:105-11. 2010
    ..We reported on reduced pericyte adhesion to high glucose-conditioned ECM and correction by thiamine. We aimed at verifying the effects of thiamine and benfotiamine on MMP-2, MMP-9 and TIMP expression and activity ..
  28. ncbi The relationship between plasma and red cell concentrations of vitamins thiamine diphosphate, flavin adenine dinucleotide and pyridoxal 5-phosphate following elective knee arthroplasty
    Andrew Gray
    Department of Orthopaedics, Royal Infirmary, Glasgow G31 2ER, UK
    Clin Nutr 23:1080-3. 2004
    ..The aim of the study was to examine the relationship between plasma and intra-cellular B-vitamins following the systemic inflammatory response of surgery...
  29. ncbi The gene mutated in thiamine-responsive anaemia with diabetes and deafness (TRMA) encodes a functional thiamine transporter
    J C Fleming
    Division of Hematology, Children s Hospital, Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 22:305-8. 1999
    b>Thiamine-responsive megaloblastic anaemia with diabetes and deafness (TRMA; MIM 249270) is an autosomal recessive disease thought to be due to a defect in thiamine (vitamin B1) transport...
  30. ncbi Increasing consumption of breakfast cereal improves thiamine status in overweight/obese women following a hypocaloric diet
    Rosa M Ortega
    Departamento de Nutricion, Facultad de Farmacia, Universidad Complutense, Madrid, Spain
    Int J Food Sci Nutr 60:69-79. 2009
    The aim of this study was to analyse the thiamine status in a group of young, overweight/obese women and to analyse the changes in this status produced by two weight-control programmes based on approximating the diet to the theoretical ..
  31. ncbi Disulfide-mediated apoptosis of human T-lymphotrophc virus type-I (HTLV-I)-infected cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis
    Yoshihiro Nishiura
    First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    Antivir Ther 14:533-42. 2009
    ..spastic paraparesis (HAM/TSP) using a compound that contained a disulfide moiety, prosultiamine, which is a homologue of allithiamine originally synthesized by allicin and thiamine-thiol, for the targeting of HTLV-I-infected cells.
  32. ncbi Thiamine deficiency in cultured neuroblastoma cells: effect on mitochondrial function and peripheral benzodiazepine receptors
    L Bettendorff
    Laboratory of Neurochemistry, University of Liege, Belgium
    J Neurochem 64:2013-21. 1995
    When neuroblastoma cells were transferred to a medium of low (6 nM) thiamine concentration, a 16-fold decrease in total intracellular thiamine content occurred within 8 days...
  33. pmc Biotin-responsive basal ganglia disease should be renamed biotin-thiamine-responsive basal ganglia disease: a retrospective review of the clinical, radiological and molecular findings of 18 new cases
    Majid Alfadhel
    Division of Genetics, Department of Pediatrics, King Abdulaziz Medical City, Riyadh, Saudi Arabia
    Orphanet J Rare Dis 8:83. 2013
    ..It is characterized by sub acute encephalopathy with confusion, seizure, dysarthria and dystonia following a history of febrile illness. If left untreated with biotin, the disease can progress to severe quadriparesis and even death...
  34. pmc Metabolic flux in both the purine mononucleotide and histidine biosynthetic pathways can influence synthesis of the hydroxymethyl pyrimidine moiety of thiamine in Salmonella enterica
    Shara Allen
    Department of Bacteriology, University of Wisconsin Madison, Madison 53706, USA
    J Bacteriol 184:6130-7. 2002
    Together, the biosyntheses of histidine, purines, and thiamine pyrophosphate (TPP) contain examples of convergent, divergent, and regulatory pathway integration...
  35. ncbi Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular disease
    G L J Page
    Academic Department of Diabetes and Endocrinology, Queen Alexandra Hospital, Portsmouth, UK
    Int J Clin Pract 65:684-90. 2011
    ..b>Thiamine is an essential cofactor in carbohydrate metabolism and individuals with diabetes are thiamine deficient...
  36. ncbi Modulation of cellular redox status by thiamine-activated NADPH oxidase confers Arabidopsis resistance to Sclerotinia sclerotiorum
    Jun Zhou
    MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, PR China
    J Exp Bot 64:3261-72. 2013
    ..Here, it was shown that the cellular redox status can be modulated by thiamine to protect Arabidopsis thaliana against Sclerotinia at the early stages of infection...
  37. pmc Relative contribution of THTR-1 and THTR-2 in thiamin uptake by pancreatic acinar cells: studies utilizing Slc19a2 and Slc19a3 knockout mouse models
    Veedamali S Subramanian
    Department of Medicine, University of California, Irvine, USA
    Am J Physiol Gastrointest Liver Physiol 302:G572-8. 2012
    ..These findings demonstrate, for the first time, that both mTHTR-1 and mTHTR-2 are involved in carrier-mediated thiamin uptake by pancreatic acinar cells...
  38. pmc A wide spectrum of clinical and brain MRI findings in patients with SLC19A3 mutations
    Kenichiro Yamada
    Department of Genetics, Institute for Developmental Research, Aichi Human Service Center, Aichi, Japan
    BMC Med Genet 11:171. 2010
    ..Homozygous or compound heterozygous mutations in SLC19A3 cause two distinct clinical phenotypes, biotin-responsive basal ganglia disease and Wernicke's-like encephalopathy. Biotin and/or thiamin are effective therapies for both diseases...
  39. ncbi Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors
    Allen A Thomas
    Array BioPharma Inc, 3200 Walnut Street, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 18:2206-10. 2008
    ..In a pharmacodynamic study, nude mice with xenografted HCT-116 tumors were dosed with 1 ('N3'-pyridyl thiamine'; 3-(6-methyl-2-amino-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium chloride hydrochloride), an ..
  40. ncbi Diabetic acido-ketosis revealing thiamine-responsive megaloblastic anemia
    O Bouyahia
    Service de Medecine infantile A, Hopital d Enfants de Tunis, Jebari, 1007 Bab Saadoun, Tunisia
    Ann Endocrinol (Paris) 70:477-9. 2009
    b>Thiamine-responsive megaloblastic anemia (TRMA) is a rare autosomal recessive disorder characterized by megaloblastic anemia, diabetes mellitus and progressive sensorineural deafness...
  41. ncbi Effect of high dose thiamine on the levels of urinary protein biomarkers in diabetes mellitus type 2
    Samreen Riaz
    School of Biological Sciences, University of the Punjab, Lahore, Pakistan
    J Pharm Biomed Anal 54:817-25. 2011
    ..Effect of high dose thiamine has also been observed on the levels of these marker proteins...
  42. ncbi Non-charged thiamine analogs as inhibitors of enzyme transketolase
    Allen A Thomas
    Array BioPharma Inc, 3200 Walnut Street, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 18:509-12. 2008
    Inhibition of the thiamine-utilizing enzyme transketolase (TK) has been linked with diminished tumor cell proliferation...
  43. ncbi Daily intake of thiamine correlates with the circulating level of endothelial progenitor cells and the endothelial function in patients with type II diabetes
    Ching Yuen Wong
    Cardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Mol Nutr Food Res 52:1421-7. 2008
    ..intake, other dietary vitamin intake, use of antihypertensives, and lipid lowering agents, a higher intake of thiamine was significantly associated with a higher level of circulating CD34(+)/KDR(+) EPC (beta = 0.49, p = 0...
  44. ncbi Effect of thiamine administration on metabolic profile, cytokines and inflammatory markers in drug-naïve patients with type 2 diabetes
    Manuel González-Ortiz
    Cardiovascular Research Unit, Physiology Department, Health Science University Center, University of Guadalajara, Guadalajara, Colonia Independencia, Mexico
    Eur J Nutr 50:145-9. 2011
    To evaluate the effect of thiamine administration on metabolic profile, cytokines and inflammatory markers in drug-naïve patients with type 2 diabetes mellitus (T2DM).
  45. ncbi Pyruvate dehydrogenase complex deficiency: four neurological phenotypes with differing pathogenesis
    Christine Barnerias
    Neuropaediatric Unit, Necker Hospital, AP HP, Paris, France
    Dev Med Child Neurol 52:e1-9. 2010
    ..To describe the phenotype and genotype of pyruvate dehydrogenase complex (PDHc) deficiency...
  46. ncbi Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats
    H Stracke
    Center of Internal Medicine, Department of Endocrinology and Metabolism, University of Giessen, Rodthohl 6, D 35385 Giessen, Germany
    Exp Clin Endocrinol Diabetes 109:330-6. 2001
    In rats with streptozotocin (STZ) induced diabetes the effect of (watersoluble) thiamine nitrate and of (lipidsoluble) benfotiamine on peripheral nerve function (motor nerve conduction velocity) as well as on the formation of advanced ..
  47. ncbi Thiamine (vitamin B1) improves endothelium-dependent vasodilatation in the presence of hyperglycemia
    Subodh Arora
    Department of Surgery, George Washington University Medical Center, Washington, DC, USA
    Ann Vasc Surg 20:653-8. 2006
    ..b>Thiamine is a coenzyme important in intracellular glucose metabolism...
  48. ncbi Benfotiamine relieves inflammatory and neuropathic pain in rats
    Gabriela M Sánchez-Ramírez
    Departamento de Farmacobiologia, Centro de Investigación y de Estudios Avanzados Coapa, Calzada de los Tenorios 235, Colonia Granjas Coapa, DF, Mexico
    Eur J Pharmacol 530:48-53. 2006
    ..Results indicate that oral administration of benfotiamine is able to reduce tactile allodynia from different origin in the rat and they suggest the use of this drug to reduce inflammatory and neuropathic pain in humans...
  49. pmc apbA, a new genetic locus involved in thiamine biosynthesis in Salmonella typhimurium
    D M Downs
    Department of Bacteriology, University of Wisconsin, Madison 53706
    J Bacteriol 176:4858-64. 1994
    In Salmonella typhimurium, the synthesis of the pyrimidine moiety of thiamine can occur by utilization of the first five steps in de novo purine biosynthesis or independently of the pur genes through the alternative pyrimidine ..
  50. ncbi Thiamine induced resistance to Plasmopara viticola in grapevine and elicited host-defense responses, including HR like-cell death
    Hatem Boubakri
    Laboratoire de Physiologie Moléculaire des Plantes, Centre de Biotechnologie de Borj Cedria, 2050 Hammam Lif, Tunisia
    Plant Physiol Biochem 57:120-33. 2012
    Recently, thiamine (VitaminB1) has been shown to induce resistance against Pseudomonas syringae in Arabidopsis plants through priming of defense responses...
  51. pmc The upregulation of thiamine (vitamin B1) biosynthesis in Arabidopsis thaliana seedlings under salt and osmotic stress conditions is mediated by abscisic acid at the early stages of this stress response
    Maria Rapala-Kozik
    Department of Analytical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    BMC Plant Biol 12:2. 2012
    Recent reports suggest that vitamin B1 (thiamine) participates in the processes underlying plant adaptations to certain types of abiotic and biotic stress, mainly oxidative stress...
  52. ncbi Kinetics of thiamin and thiamin phosphate esters in human blood, plasma and urine after 50 mg intravenously or orally
    C M Tallaksen
    Medical Department, Aker University Hospital, Norway
    Eur J Clin Pharmacol 44:73-8. 1993
    ..The relative bioavailability of thiamin was 5.3%. A moderate amount of the administered thiamin was stored in blood. Other body tissues must play an important part, therefore, in the distribution of thiamin...
  53. ncbi Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy
    Lukáš Pácal
    Department of Pathophysiology, Masaryk University, Brno, Czech Republic
    Nephrol Dial Transplant 26:1229-36. 2011
    ..We hypothesized that thiamine status (plasma and erythrocyte levels of thiamine and its esters) together with genetic variability in key PPP ..
  54. ncbi Transport of high concentration of thiamin, riboflavin and pyridoxine across intestinal epithelial cells Caco-2
    Magdalena Zielińska-Dawidziak
    Department of Biotechnology and Food Microbiology, University of Life Sciences in Poznan
    J Nutr Sci Vitaminol (Tokyo) 54:423-9. 2008
    ..At high vitamin concentration the transepithelial flux of vitamins in both directions was similar, which proves the mechanism of passive transport...
  55. ncbi Thiamine suppresses thermal hyperalgesia, inhibits hyperexcitability, and lessens alterations of sodium currents in injured, dorsal root ganglion neurons in rats
    Xue Song Song
    Department of Neurobiology, Parker University Research Institute, Dallas, Texas 75229, USA
    Anesthesiology 110:387-400. 2009
    ..that may support the clinical utility of B vitamins in chronic pain treatment, this study investigated effects of thiamine (B1) on the excitability and Na currents of dorsal root ganglion (DRG) neurons that have been altered by nerve ..
  56. ncbi Biotin-responsive basal ganglia disease-linked mutations inhibit thiamine transport via hTHTR2: biotin is not a substrate for hTHTR2
    Veedamali S Subramanian
    Dept of Medicine, University of California, Irvine, USA
    Am J Physiol Cell Physiol 291:C851-9. 2006
    The water-soluble micronutrient thiamine is required for normal tissue growth and development in humans...
  57. pmc Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives
    Marie Laure Volvert
    Center for Cellular and Molecular Neurobiology, University of Liege, Avenue de l Hopital, 1, 4000 Liege, Belgium
    BMC Pharmacol 8:10. 2008
    Lipid-soluble thiamine precursors have a much higher bioavailability than genuine thiamine and therefore are more suitable for therapeutic purposes...
  58. ncbi Thiamine prevents obesity and obesity-associated metabolic disorders in OLETF rats
    Takao Tanaka
    Laboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan
    J Nutr Sci Vitaminol (Tokyo) 56:335-46. 2010
    We previously found that thiamine mitigates metabolic disorders in spontaneously hypertensive rats, harboring defects in glucose and fatty acid metabolism...
  59. ncbi Determination of the genetic, molecular, and biochemical basis of the Arabidopsis thaliana thiamin auxotroph th1
    Imad Ajjawi
    Department of Biochemistry and Molecular Biology, University of Nevada, Reno, NV 89557, USA
    Arch Biochem Biophys 459:107-14. 2007
    ..Studies were also performed to identify the chloroplast as the specific subcellular locale of the Arabidopsis HMPPK/TMPPase...
  60. pmc Signs of preclinical Wernicke's encephalopathy and thiamine levels as predictors of neuropsychological deficits in alcoholism without Korsakoff's syndrome
    Anne Lise Pitel
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Neuropsychopharmacology 36:580-8. 2011
    ..Whole blood thiamine was also measured in 22 of the comparison group and 28 alcoholics...
  61. ncbi Thiamin pyrophosphokinase is required for thiamin cofactor activation in Arabidopsis
    Imad Ajjawi
    Department of Biochemistry and Molecular Biology, University of Nevada, Reno, NV 89557, USA
    Plant Mol Biol 65:151-62. 2007
    ..These results suggest that TPK activity provides the sole mechanism by which exogenous and de novo derived thiamin is converted to the enzyme cofactor TPP...
  62. ncbi The multifaceted therapeutic potential of benfotiamine
    Pitchai Balakumar
    Department of Pharmacology, SB College of Pharmacy, Sivakasi 626130, India
    Pharmacol Res 61:482-8. 2010
    b>Thiamine, known as vitamin B(1), plays an essential role in energy metabolism. Benfotiamine (S-benzoylthiamine O-monophoshate) is a synthetic S-acyl derivative of thiamine...
  63. ncbi Effect of cysteine, methionine, ascorbic acid and thiamine on arsenic-induced oxidative stress and biochemical alterations in rats
    D Nandi
    Environmental Medicine Laboratory, Division of Medicine, Indian Veterinary Research Institute, Izatnagar, India
    Toxicology 211:26-35. 2005
    ..ameliorative potential of certain amino acids like cysteine, methionine and vitamins like ascorbic acid and thiamine on some of the parameters indicative of oxidative stress in liver, kidney and blood and of hepatic and renal ..
  64. ncbi Molecular characterization of a thiJ-like gene in Chinese cabbage
    Kyung Jin Oh
    Division of Life Sciences, College of Natural Sciences, Chungbuk National University, Cheongju 360 763, Korea
    J Biochem Mol Biol 37:343-50. 2004
    ..Examination of the tissue-specific expression revealed that the induction of the cabbage gene expression by BTH occurs in the leaf, stem, and floral tissues but not in the root...
  65. ncbi The genes and enzymes involved in the biosynthesis of thiamin and thiamin diphosphate in yeasts
    Ewa Kowalska
    Department of Analytical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387, Krakow, Poland
    Cell Mol Biol Lett 13:271-82. 2008
    ....
  66. ncbi Thiamine deficiency in critically ill patients with sepsis
    Michael W Donnino
    Department of Emergency Medicine and Internal Medicine, Division of Pulmonary Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Crit Care 25:576-81. 2010
    The objective of the study was to determine the prevalence of absolute thiamine deficiency (TD) in critically ill patients with sepsis and to examine the association between thiamine levels and lactic acidosis.
  67. ncbi Thiamine reverses hyperglycemia-induced dysfunction in cultured endothelial cells
    E Ascher
    Division of Vascular Surgery, Maimonides Medical Center, Brooklyn, NY 11219, USA
    Surgery 130:851-8. 2001
    ..This study investigates whether thiamine, an important coenzyme in intracellular glucose metabolism, improves endothelial cell migration and decreases von ..
  68. pmc Thiamine-responsive megaloblastic anemia: identification of novel compound heterozygotes and mutation update
    Anke K Bergmann
    Division of Hematology and Oncology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    J Pediatr 155:888-892.e1. 2009
    To determine causative mutations and clinical status of 7 previously unreported kindreds with TRMA syndrome, (thiamine-responsive megaloblastic anemia, online Mendelian inheritance in man, no...
  69. pmc A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy
    Alaa Alkhalaf
    Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Diabetes Care 33:1598-601. 2010
    ..To investigate the effect of benfotiamine on urinary albumin excretion (UAE) and the tubular damage marker kidney injury molecule-1 (KIM-1) in patients with type 2 diabetes and nephropathy...
  70. ncbi High-dose thiamine therapy counters dyslipidemia and advanced glycation of plasma protein in streptozotocin-induced diabetic rats
    Nikolaos Karachalias
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
    Ann N Y Acad Sci 1043:777-83. 2005
    ..STZ) diabetic rat experimental model of diabetes on insulin maintenance therapy exhibits dyslipidemia, mild thiamine deficiency, and increased plasma protein advanced glycation end products (AGEs)...
  71. ncbi Down-regulation of thiamine transporter THTR2 gene expression in breast cancer and its association with resistance to apoptosis
    Shuqian Liu
    Department of Pediatrics, University of Kentucky, Lexington, KY 40536, USA
    Mol Cancer Res 1:665-73. 2003
    The recent molecular identification of two thiamine transporters, SLC19A2 (THTR1) and SLC19A3 (THTR2), has provided the opportunity to study thiamine transporter gene expression in human malignancies...
  72. ncbi Thiamine withdrawal can lead to diabetic ketoacidosis in thiamine responsive megaloblastic anemia: report of two siblings
    Selim Kurtoglu
    Division of Paediatric Endocrinology and Metabolism, Department of Paediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey
    J Pediatr Endocrinol Metab 21:393-7. 2008
    b>Thiamine responsive megaloblastic anemia syndrome (TRMA), an autosomal recessive disorder caused by the deficiency of thiamine transporter protein, is the association of diabetes mellitus, anemia and deafness...
  73. ncbi Identification of a mouse thiamine transporter gene as a direct transcriptional target for p53
    P K Lo
    Institute of Biochemistry, National Yang Ming University, Shih Pai, Taipei 112, Taiwan
    J Biol Chem 276:37186-93. 2001
    ..Sequence analysis of the full-length cDNA revealed its identity as the mouse homologue of the human thiamine transporter 1 (THTR-1). Induction of the mouse THTR-1 (mTHTR-1) mRNA was detectable as early as 1 h at 32...
  74. ncbi Brain uptake of thiamine-coated nanoparticles
    Paul R Lockman
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University HSC, Amarillo, TX 79106 1712, USA
    J Control Release 93:271-82. 2003
    ..To further these studies and to specifically target brain, we have incorporated thiamine as a surface ligand on the nanoparticles...
  75. ncbi Thiamine-responsive megaloblastic anemia syndrome: long term follow-up
    Caterina Borgna-Pignatti
    Department of Clinical and Experimental Medicine Pediatrics, University of Ferrara, Ferrara, Italy
    J Pediatr 155:295-7. 2009
    b>Thiamine-responsive megaloblastic anemia is a rare autosomal recessive disorder whose main symptoms are anemia, diabetes mellitus, and sensorineural deafness...
  76. ncbi SLC19: the folate/thiamine transporter family
    Vadivel Ganapathy
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, GA 30912 2100, Augusta, USA
    Pflugers Arch 447:641-6. 2004
    ..family are expressed ubiquitously and mediate the transport of two important water-soluble vitamins, folate and thiamine. The concentrative transport of substrates mediated by the members of this gene family is energized by ..
  77. ncbi Outbreak of beriberi in the state of Maranhão, Brazil: revisiting the mycotoxin aetiologic hypothesis
    Helena Cristina Alves Vieira Lima
    Brazilian Field Epidemiology Training Program, Secretariat of Health Surveillance, Ministry of Health, Brasilia
    Trop Doct 40:95-7. 2010
    Beriberi is caused by thiamine deficiency. Early 20th century epidemics in Japan were attributed to rice contaminated by citreoviridin mycotoxin...
  78. ncbi Prodrug thiamine analogs as inhibitors of the enzyme transketolase
    Yvan Le Huerou
    Array BioPharma Inc, 3200 Walnut Street, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 18:505-8. 2008
    ..Compound 5a ('N3'-pyridyl thiamine'; 3-(6-methyl-2-amino-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium chloride hydrochloride), an ..
  79. ncbi Thiamine and benfotiamine prevent apoptosis induced by high glucose-conditioned extracellular matrix in human retinal pericytes
    Elena Beltramo
    Laboratory of Diabetic Retinopathy, Department of Internal Medicine, University of Turin, Torino, Italy
    Diabetes Metab Res Rev 25:647-56. 2009
    ..Since human and bovine pericytes may behave differently in conditions mimicking the diabetic milieu, we verified the behaviour of human retinal pericytes cultured on HG-conditioned ECM...
  80. ncbi Bioadhesive capacity and immunoadjuvant properties of thiamine-coated nanoparticles
    Hesham H Salman
    Department of Pharmaceutical Technology, University of Navarra, 31008 Pamplona, Spain
    Vaccine 25:8123-32. 2007
    ..b>Thiamine was used as specific ligand-nanoparticle conjugate (TNP) to target specific sites within the gastrointestinal ..
  81. ncbi Epilepsy in children with infantile thiamine deficiency
    A Fattal-Valevski
    Pediatric Neurology Unit, Dana Children s Hospital, Sourasky Medical Center, 6 Weitzman St, Tel Aviv, 64239, Israel
    Neurology 73:828-33. 2009
    To report the follow-up findings of 7 children with severe epilepsy as a result of thiamine deficiency in infancy caused by a defective soy-based formula.
  82. ncbi Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness
    V Labay
    Department of Genetics, Tamkin Human Molecular Genetics Research Facility, Technion Israel Institute of Technology, Bruce Rappaport Faculty of Medicine, Haifa
    Nat Genet 22:300-4. 1999
    b>Thiamine-responsive megaloblastic anaemia (TRMA), also known as Rogers syndrome, is an early onset, autosomal recessive disorder defined by the occurrence of megaloblastic anaemia, diabetes mellitus and sensorineural deafness, responding ..
  83. ncbi Biotin-responsive basal ganglia disease in ethnic Europeans with novel SLC19A3 mutations
    Rabab Debs
    Federation of Nervous System Diseases, Assistance Publique Hopitaux de Paris, Hopital de la Salpetriere, Universite Pierre et Marie Curie, Paris Cedex 13, France
    Arch Neurol 67:126-30. 2010
    ..To report the first 2 European cases of biotin-responsive basal ganglia disease and novel SLC19A3 mutations...
  84. pmc Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegans
    Liesbeth de Jong
    Department of Biology, McGill University, Montreal, Quebec H3A 1B1, Canada
    Genetics 168:845-54. 2004
    b>Thiamine (vitamin B1) is required in the diet of animals, and thiamine deficiency leads to diseases such as beri-beri and the Wernicke-Korsakoff syndrome...
  85. pmc Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol
    G A Sprenger
    Institut für Biotechnologie 1 des Forschungszentrums Jülich, Germany
    Proc Natl Acad Sci U S A 94:12857-62. 1997
    ....
  86. ncbi Functional characterization of the thi1 promoter region from Arabidopsis thaliana
    Denise Teixeira Ribeiro
    Depto de Botanica, Instituto de Biociencias, Universidade de Sao Paulo, Rua do Matao, 277, 05508 900 Sao Paulo, SP, Brazil
    J Exp Bot 56:1797-804. 2005
    The Arabidopsis thaliana THI1 protein is involved in thiamine biosynthesis and is targeted to both chloroplasts and mitochondria by N-terminal control regions...
  87. pmc Vitamin B1 biosynthesis in plants requires the essential iron sulfur cluster protein, THIC
    Maja Raschke
    ETH Zurich, Institute of Plant Sciences, 8092 Zurich, Switzerland
    Proc Natl Acad Sci U S A 104:19637-42. 2007
    ..The results suggest that vitamin B1 biosynthesis in plants is in fact more similar to prokaryotic counterparts and that the THIC protein is likely to be the key regulatory protein in the pathway...
  88. ncbi Concomitant determination of thiamin and its phosphate esters in human blood and serum by high-performance liquid chromatography
    C M Tallaksen
    Department of Medicine, Aker University Hospital, Oslo, Norway
    J Chromatogr 564:127-36. 1991
    ..The eluent consists of acetonitrile and phosphate buffer, in the ratios 90:10 (v/v) for the elution of thiamine and 60:40 (v/v) for the phosphate esters. The four compounds are eluted within 15 min...
  89. ncbi Thiamine transporter gene expression and exogenous thiamine modulate the expression of genes involved in drug and prostaglandin metabolism in breast cancer cells
    Shuqian Liu
    Department of Pediatrics, College of Medicine, University of Kentucky, Lexington, Kentucky, USA
    Mol Cancer Res 2:477-87. 2004
    In previous studies, we have shown that RNA levels of the thiamine transporter THTR2 were down-regulated in breast cancer tumors in comparison with normal tissues and that THTR2-mediated increases in thiamine uptake activity contributed ..
  90. ncbi Thiamin biosynthesis in Escherichia coli. Identification of ThiS thiocarboxylate as the immediate sulfur donor in the thiazole formation
    S V Taylor
    Department of Chemistry, Cornell University, Baker Laboratory, Ithaca, New York 14853, USA
    J Biol Chem 273:16555-60. 1998
    ..ThiF catalyzes the adenylation by ATP of the carboxyl-terminal glycine of ThiS. This reaction is likely to be involved in the activation of ThiS for sulfur transfer from cysteine or from a cysteine-derived sulfur donor...
  91. ncbi Structural and mechanistic studies on ThiO, a glycine oxidase essential for thiamin biosynthesis in Bacillus subtilis
    Ethan C Settembre
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
    Biochemistry 42:2971-81. 2003
    ..The ThiO structure, as well as the observation that N-cyclopropylglycine is a good substrate, supports a hydride transfer mechanism for the enzyme. A mechanistic proposal for the role of ThiO in thiazole biosynthesis is also described...
  92. ncbi Thi1, a thiamine biosynthetic gene in Arabidopsis thaliana, complements bacterial defects in DNA repair
    C R Machado
    Depto de Biologia, Universidade de Sao Paulo, Brazil
    Plant Mol Biol 31:585-93. 1996
    ..to a stress related gene from two species of Fusarium (sti35) and to genes whose products participate in the thiamine biosynthesis pathway, THI4, from Saccharomyces cerevisiae and nmt2 from Schizosaccharomyces pombe...
  93. ncbi Prevention of incipient diabetic cardiomyopathy by high-dose thiamine
    Yuka Kohda
    Laboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan
    J Toxicol Sci 33:459-72. 2008
    ..The hexosamine biosynthesis pathway has been implicated in signaling for fibrosis by the kidney. Thiamine (vitamin B(1)) is an indispensable coenzyme and required at intracellular glucose metabolism...
  94. ncbi The effect of thiamine supplementation on tumour proliferation. A metabolic control analysis study
    B Comin-Anduix
    Department of Biochemistry and Molecular Biology, IDIBAPS, University of Barcelona, Spain
    Eur J Biochem 268:4177-82. 2001
    b>Thiamine deficiency frequently occurs in patients with advanced cancer and therefore thiamine supplementation is used as nutritional support...
  95. ncbi Thiamine-responsive megaloblastic anemia: early diagnosis may be effective in preventing deafness
    Hasan Onal
    Department of Pediatrics, Bakirköy Training Hospital, Istanbul, Turkey
    Turk J Pediatr 51:301-4. 2009
    b>Thiamine-responsive megaloblastic anemia syndrome is an autosomal recessive disorder characterized by diabetes mellitus, megaloblastic anemia and sensorineural hearing loss...
  96. pmc Both thiamine uptake and biosynthesis of thiamine precursors are required for intracellular replication of Listeria monocytogenes
    Kristina Schauer
    Zentralinstitut für Ernährungs und Lebensmittelforschung, Abteilung Mikrobiologie, Technische Universitat Munchen, Weihenstephaner Berg, Freising, Germany
    J Bacteriol 191:2218-27. 2009
    b>Thiamine pyrophosphate is an essential cofactor involved in central metabolism and amino acid biosynthesis and is derived from thiamine (vitamin B(1))...
  97. ncbi The mechanism of action of bacimethrin, a naturally occurring thiamin antimetabolite
    J J Reddick
    Department of Chemistry and Chemical Biology, Cornell University, Baker Laboratory, Ithaca, NY 14853, USA
    Bioorg Med Chem Lett 11:2245-8. 2001
    ..Bacimethrin does not cause repression of the genes coding for the thiamin biosynthetic enzymes...
  98. ncbi thiBPQ encodes an ABC transporter required for transport of thiamine and thiamine pyrophosphate in Salmonella typhimurium
    E Webb
    Department of Bacteriology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Biol Chem 273:8946-50. 1998
    In Salmonella typhimurium, thiamine pyrophosphate (TPP) is a required cofactor for several enzymes in central metabolism...
  99. pmc The structure and ligand binding properties of the B. subtilis YkoF gene product, a member of a novel family of thiamin/HMP-binding proteins
    Yancho Devedjiev
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville 22908 0736, USA
    J Mol Biol 343:395-406. 2004
    ..Calorimetric data confirmed that YkoF binds two thiamin molecules with varying affinities and a thiamine-YkoF complex was obtained by co-crystallization. The atomic model of the complex was refined using data to 2...
  100. pmc Deletion of SLC19A2, the high affinity thiamine transporter, causes selective inner hair cell loss and an auditory neuropathy phenotype
    M C Liberman
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    J Assoc Res Otolaryngol 7:211-7. 2006
    Mutations in the gene coding for the high-affinity thiamine transporter Slc19a2 underlie the clinical syndrome known as thiamine-responsive megaloblastic anemia (TRMA) characterized by anemia, diabetes, and sensorineural hearing loss...
  101. ncbi Age-related vulnerability to diencephalic amnesia produced by thiamine deficiency: the role of time of insult
    Shane R Pitkin
    Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, Binghamton, NY 13905, USA
    Behav Brain Res 148:93-105. 2004
    ..A rodent model of Wernicke-Korsakoff Syndrome (WKS), acute pyrithiamine-induced thiamine deficiency (PTD), produces diencephalic damage and impairments of memory similar to what is seen in WKS patients...

Research Grants62

  1. Trophic interactions in developing and adult inner ear
    Gabriel Corfas; Fiscal Year: 2013
    ..we evaluate inner hair cell contributions to long-term neuronal maintenance using mice lacking the high-affinity thiamine transporter such that dietary thiamine restriction leads to widespread and selective loss of inner hair cells, ..
  2. Thiamine Deficiency and Acquired Auditory Neuropathy
    M Charles Liberman; Fiscal Year: 2013
    ..Two recent observations from our laboratory suggest that thiamine deficiency may be a key to the genesis of selective IHC loss, and therefore to acquired AN, in both prematurity ..
  3. Mechanism/Regulation of Intestinal Thiamin Uptake
    Hamid M Said; Fiscal Year: 2013
    ..abstract_text> ..
  4. Role of Astrocyte Injury in Neuroprotection
    Martin A Philbert; Fiscal Year: 2012
    ..diseases including Alzheimer's and Parkinson's disease and in energy deprivation syndromes such as thiamine deficiency and antimetabolite poisoning...
  5. Thiamine as a Metabolic Resuscitator in Septic Shock
    Michael William Donnino; Fiscal Year: 2012
    ..Vitamin B1 (thiamine) is a co-factor for pyruvate dehydrogenase, an essential enzyme for aerobic metabolism...
  6. REGULATION OF METHIONINE METABOLISM IN BACILLUS SUBTILIS
    Tina M Henkin; Fiscal Year: 2013
    ..riboswitch RNAs, the S box and the SMK box, with additional efforts on the lysine-binding L box, the thiamine pyrophosphate-binding Thi box, and RNA thermosensors that respond to changes in temperature...
  7. Memory, Thiamine Levels, and Brain Structure in Heart Failure
    MARY ANN WOO; Fiscal Year: 2010
    ..in HF, with neural damage and symptoms (short-term memory loss, depression) similar to those seen in persons with thiamine deficiency...
  8. Mechanisms of Pancreatic Thiamin Uptake:Effect of Alcohol
    Hamid M Said; Fiscal Year: 2013
    ....
  9. Pyruvate Dehydrogenase E1: Structure-Function Studies
    William F Furey; Fiscal Year: 2012
    ..The overall objective of this research is to extend our knowledge of structure-function relationships in thiamine diphosphate dependent a-keto acid decarboxylases, a large and ubiquitous class of enzymes of critical importance ..
  10. Effect of Thiamine on Pyruvate Dehydrogenase Activity in Septic Shock
    Michael William Donnino; Fiscal Year: 2013
    ..Vitamin B1 (thiamine) is a co-factor for pyruvate dehydrogenase, an essential enzyme for aerobic metabolism...
  11. Structural Studies of Enzymes of Thiamin Biosynthesis
    Steven E Ealick; Fiscal Year: 2013
    ..The research has implications for the commercial production of thiamin using fermentation, and for the development of antimicrobial agents that target thiamin biosynthesis. ..
  12. NAD Biosynthesis and the Regulation of Sirtuins
    JEFFREY SCOTT SMITH; Fiscal Year: 2012
    ..We have also recently identified thiamine biosynthesis as a metabolic pathway controlled by the Sir2 and Hst1 Sirtuins in response to changes in NAD and ..
  13. Adaptive Regulation of Vitamin B1 Transport
    Jason A Zastre; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vitamin B1 (thiamine) is a critical enzyme cofactor within the glycolytic metabolism network that is fundamentally required to sustain the bioenergetic and anabolic needs of all cells...
  14. Hyperpolarized 13C Markers of Diabetic Nephropathy and Treatment Response
    Zhen Jane Wang; Fiscal Year: 2013
    ..factor erythroid 2-related factor 2 (Nrf2) pathway activator (Sulforaphane), and a transketolase activator (Thiamine) using the HP probes, with particular attention to the agents'targeted effects on oxidative stress and ..
  15. The mechanistic enzymology of thiamin biosynthesis
    Tadhg P Begley; Fiscal Year: 2013
    ..18F-thiamin has potential use, as an imaging agent, in basic human biology and in tumor rifitfictinn. . '...
  16. Patient-Oriented Research in Pediatric Hematology
    Ellis J Neufeld; Fiscal Year: 2010
    ..The first aim/project is to further characterize the rare human disorder, thiamine-responsive megaloblastic anemia, due to defects in the gene for high-affinity thiamine transporter, SLC19A2...
  17. Bioactivity and Vitamins in Flash-heated Breastmilk
    Caroline Chantry; Fiscal Year: 2005
    ..aliquots of heated and unheated milk we will measure and compare: a) concentrations of vitamins A, ascorbic acid, thiamine, riboflavin, pyridoxine, folate and B12, known to be relatively heat-sensitive; b) concentration and ..
  18. HISTAMINE, IL-1 & NITRIC OXIDE IN WERNICKE LESIONS
    PHILIP LANGLAIS; Fiscal Year: 2002
    b>Thiamine deficiency-induced pathologic damage in humans is associated with Wernicke's encephalopathy (WE), Korsakoffs syndrome, and mixed sensory motor neuropathy. The prevalence of WE ranges from 1.7-2...
  19. SPECTROSCOPIC STUDIES OF ENZYME/SUBSTRATE COMPLEXES
    George Reed; Fiscal Year: 2007
    ..b>Thiamine-pyrophosphate (TPP), the cofactor form of thiamine, is essential in carbohydrate metabolism...
  20. Biology of lipoamide dehydrogenase and 2-hydroxy-3-oxoadipate synthase in Mtb
    Carl F Nathan; Fiscal Year: 2013
    ..Tet-regulated allele have developed a novel strategy to synthesize HOAS inhibitors from an analog of the cofactor thiamine diphosphate...
  21. Carbene-Catalyzed Reactions with Vinyl Sulfones
    ROXANNE L ATIENZA; Fiscal Year: 2012
    ..origin and inspiration of an NHC as a catalyst is in the human body's biological systems, where Nature uses thiamine, an NHC, to generate acetyl CoA, an important building block for polyketides...
  22. VITAMIN DELIVERY BY PLACENTA
    Richard Rose; Fiscal Year: 1990
    ..Efforts will be directed at understanding the transfer of nicotinic acid, Riboflavin, pantothenic acid, thiamine, ascorbic acid and the product of ascorbic acid oxidation, dehydroascorbic acid...
  23. BIOSYNTHESIS OF VITAMIN B1 AND VITAMIN B6
    IAN SPENSER; Fiscal Year: 2000
    ..It is the long term objective of the study to identify the step in each pathway which is blocked in human tissues, thereby making the compounds Vitamins. ..
  24. Carbohydrate Metabolic Pathways
    Faramarz Ismail Beigi; Fiscal Year: 2007
    ..4) To test whether thiamine's prevention of experimental diabetic complications is by shunting glycolytic intermediates from pathways of ..
  25. GENETIC MECHANISMS OF ALCOHOLIC ORGANIC BRAIN DISEASE
    Peter Martin; Fiscal Year: 1992
    ..Although the relative contributions of ethanol neurotoxicity and thiamine deficiency (a frequent complication of alcoholism) in the pathogenesis of alcoholic organic brain disorders ..
  26. MOLECULAR BASIS AND ENZYMOLOGY OF MICROBIAL BIOSYNTHESIS
    F Tabita; Fiscal Year: 2003
    ..For example, TK is required fro thiamine metabolism in all cells and alteration of its functional properties leads to severe pathologies including ..
  27. NEUROBIOLOGICAL MECHANISMS OF DIENCEPHALIC AMNESIA
    Robert Mair; Fiscal Year: 2002
    ..The previous 10-years of this project have shown that in a rodent model of thiamine-deficiency amnesia (similar to Korsakoff's), the critical lesions occurred in the intralaminar nuclei (ILn) of ..
  28. Epigenetic Contributiuns to Delirium in Mechanically Ventilated ICU Patients
    MARY ELIZABETH LOUGH; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): PURPOSE: This study will examine the association between delirium and thiamine levels, plus environmental and genetic pre-disposition to thiamine deficiency in intensive care unit (ICU) patients who ..
  29. MECHANISMS OF ENZYMIC AND NONENZYMIC THIAMIN REACTIONS
    Michael Washabaugh; Fiscal Year: 1993
    ..Using isotopic probes, it will be determined whether the C alpha-carbanion has a significant lifetime on PDC...
  30. BIOMETALS, OXIDATIVE STRESS, AND AB AMYLOIDOSIS
    Xudong Huang; Fiscal Year: 2005
    ..impact of dietary metal supplementation with Fe, Cu and Zn, as well as oxidative stress induced by the dietary thiamine deficiency, upon Abeta amyloid pathology and non-amyloid pathology using APP2576 mice; (ii) to evaluate effects ..
  31. Pathophysiology of thiamine-responsive anemia syndrome
    Ellis Neufeld; Fiscal Year: 2006
    The goal of this proposal is to determine the pathophysiology of the autosomal recessive disorder. Thiamine-Responsive Megaloblastic Anemia (TRMA)...
  32. BRAIN MR SPECTROSCOPIC STUDIES OF THIAMINE DEFICIENCY
    Haakil Lee; Fiscal Year: 2000
    b>Thiamine deficiency (TD), a frequent complication of alcoholism or other disorders that interfere with normal ingestion of food, may result in brain damage...
  33. MOLEC GENETIC & BIOCHEM INVESTIGATION OF THIAMINE TRANS
    CHARLES SINGLETON; Fiscal Year: 2000
    DESCRIPTION: Thiamine deficiency [TD], a frequent complication of alcoholism, contributes significantly to the development of damage in various organ systems, including the brain, of alcoholics and malnourished individuals...
  34. BIOSYNTHESIS AND INTERCONVERSION OF PURINES
    JOSEPH GOTS; Fiscal Year: 1980
    ..alterations of the reactions, to determine the interplay of purine biosynthesis with that of vitamins such as thiamine and folate cofactors...
  35. PHYSIOLOGICAL FUNCTIONS AND METABOLISM OF THIAMINE
    CLARK GUBLER; Fiscal Year: 1980
    It is proposed to study the biochemical and functional changes in various tissues of rats made thiamine-deficient by thiamine deprivation and treatment by thiamine antagonists and by various types of stress...
  36. Mouse Models of Vitamin Transport Defects
    Judith Fleming; Fiscal Year: 2004
    ..member of the vitamin transporter family that includes the reduced folate carrier, SLC 19A1 and the high-affinity thiamine transporter, SLC19A2...
  37. THIAMINE DEFICIENCY, MEMORY, AND BRAIN GLUCOSE UPTAKE
    Frank Sharp; Fiscal Year: 1980
    ..b>Thiamine is known to be an important coenzyme in normal brain glucose oxidation...
  38. NEUROTROPHINS AND AN ANIMAL MODEL OF FIBROMYALGIA
    ALICE LARSON; Fiscal Year: 2003
    ..substance P (SP) and are regulated by nerve growth factor (NGF), while others are characterized by the enzyme thiamine monophosphatase (TMPase) and are supported by glial derived neurotrophic factor (GDNF)...
  39. Molecular Characterization of the SLC19A2 Promoter
    JACK REIDLING; Fiscal Year: 2005
    Dietary thiamine is an essential nutrient for humans. The uptake of thiamine in the intestine has been well studied but the molecular mechanism and regulation of the uptake process is not well understood...
  40. Measuring Metabolites using Riboswitch reports
    Ronald Breaker; Fiscal Year: 2006
    ..are widely distributed in bacteria and respond to such central molecules as glucosamine-6-phosphate (glcN6P) and thiamine pyrophosphate (TPP)...
  41. ETHANOL EFFECTS ON VITAMIN TRANSPORT/MITOGENIC SIGNALING
    George Henderson; Fiscal Year: 1993
    ..Specific aims are 1) to establish the mechanisms of thiamine (B1) and vitamin B6 transport by the term human placenta, 2) to determine the effect of ethanol on these and 30 ..
  42. PATHOGENESIS & TREATMENT OF ALCOHOL-INDUCED DISEASES
    Charles Lieber; Fiscal Year: 1980
    ..Interaction of alcohol and liver disease with thiamine metabolism will be evaluated including the possible consequences on the central nervous system...
  43. HYDROXAMIC ACID PRODUCTION IN MICROBIAL ECOSYSTEMS
    Michael Corbett; Fiscal Year: 1980
    ..nitroso compounds are partially converted into aromatic hydroxamic acids by means of the action of certain thiamine dependent enzymes...
  44. BIOCHEMICAL LENS DAMAGE AND CATARACT RISK FACTORS
    Giovanni Maraini; Fiscal Year: 1990
    ..Factors under investigation include epithelial enzymes, evaluation of thiamine and riboflavin status, sugar alcohols, water and ion content...
  45. 500 MHZ NMR SPECTROMETER FOR STRUCTURAL BIOLOGY
    Robert Oswald; Fiscal Year: 2000
    ..Other projects focus on mechanisms of enzyme catalysis and inhibition, including thiamine sarcoma virus protease mutant (Vogt, Nicholson)...
  46. Cell Biology of Human Thiamine Transporters
    VEEDAMALI SUBRAMANIAN; Fiscal Year: 2005
    b>Thiamine (vitamin B1) is an important nutrient that is essential for human health...
  47. THE ROLE OF GLYOXYLIC ACID IN DISEASE
    RONALD BROSEMER; Fiscal Year: 1980
    The role of thiamine in the etiology of human diseases is being investigated...
  48. BIOSYNTHESIS OF VITAMIN B1 (THIAMINE)
    EDWARD BELLION; Fiscal Year: 1980
    The research project concerns the mechanism of biosynthesis of vitamin B1 (thiamine) in bacteria...
  49. ENZYMATIC AND NON-ENZYMATIC DESTRUCTION OF THIAMINE
    JOHN ZOLTEWICZ; Fiscal Year: 1980
    ..This work with model substrates may provide information which may lead to an understanding of the mechanism of action of thiaminase I. ..
  50. Electrophysiologic Measurements in Diabetic Neuropathy
    Joseph Arezzo; Fiscal Year: 2007
    ..an ARI and lipid soluble thiamine derivative)...
  51. The Role of Acetylcholine Dysfunction in Diencephalic Amnesia
    Lisa M Savage; Fiscal Year: 2010
    ..Such experiments are critical to understanding the role of acetylcholine dysfunction in amnesia and thus the development of pharmacotherapeutics. ..
  52. Mechanism/regulation of human intestinal thiamin uptake
    HAMID SAID; Fiscal Year: 2008
    ..This should ultimately assist us in the designing of effective strategies to optimize thiamin body homeostasis in conditions associated with thiamin deficiency and sub-optimal levels. ..
  53. C elegans:a model to study intestinal water-soluble vitamins transport in vivo
    HAMID SAID; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  54. Mitochondiral enzymes/oxidative stress in Alzheimer's
    Gary Gibson; Fiscal Year: 2004
    ..These models will also provide systems to test the efficacy of approaches to limit or reverse the changes in mitochondria. ..
  55. AGE/NUTRITION/GENES IN MODELS OF PSYCHIATRIC DISORDERS
    Gary Gibson; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Thiamine (vitamin B1) deficiency (TD) produces a mild, chronic impairment of oxidative metabolism that models the diminished metabolism and reduced activities of the thiamine-dependent ..
  56. SIGNAL TRANSDUCTION SYSTEMS IN ALZHEIMERS DISEASE
    Gary Gibson; Fiscal Year: 2003
    ..abstract_text> ..