phenobarbital

Summary

Summary: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory GAMMA-AMINOBUTYRIC ACID subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.

Top Publications

  1. ncbi Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling
    Shingo Mutoh
    Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Sci Signal 6:ra31. 2013
  2. ncbi The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice
    Yukio Yamamoto
    Laboratories of Reproductive and Developmental Toxicology and Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, Research TrianglePark, NC, USA
    Cancer Res 64:7197-200. 2004
  3. ncbi A comparison of Drosophila melanogaster detoxification gene induction responses for six insecticides, caffeine and phenobarbital
    Lee Willoughby
    Centre for Environmental Stress and Adaptation Research CESAR, Department of Genetics, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010, Australia
    Insect Biochem Mol Biol 36:934-42. 2006
  4. ncbi Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors
    H Aydinlik
    , , Wilhelmstr. 56, , Germany
    Oncogene 20:7812-6. 2001
  5. ncbi P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats
    Heidrun Potschka
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Bunteweg 17, D 30559, Hannover, Germany
    Neurosci Lett 327:173-6. 2002
  6. ncbi Cell shape, cell-cell contact, cell-extracellular matrix contact and cell polarity are all required for the maximum induction of CYP2B1 and CYP2B2 gene expression by phenobarbital in adult rat cultured hepatocytes
    Hiroaki Oda
    Laboratory of Nutritional Biochemistry, Department of Applied Molecular Biosciences, Nagoya University, Nagoya 464 8601, Japan
    Biochem Pharmacol 75:1209-17. 2008
  7. ncbi Comparison of phenobarbital with bromide as a first-choice antiepileptic drug for treatment of epilepsy in dogs
    Dawn Merton Boothe
    Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    J Am Vet Med Assoc 240:1073-83. 2012
  8. pmc β-Catenin loss in hepatocytes promotes hepatocellular cancer after diethylnitrosamine and phenobarbital administration to mice
    Prince Kwaku Awuah
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e39771. 2012
  9. ncbi Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21(WAF1/Cip1), cyclin D1 and Ogg1
    Anna Kinoshita
    First Department of Pathology, Osaka City University Medical School, Abeno Ku, Asahi machi 1 4 3, Osaka 545 8585, Japan
    Carcinogenesis 23:341-9. 2002
  10. pmc Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver
    John P Thomson
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK
    Nucleic Acids Res 41:5639-54. 2013

Detail Information

Publications339 found, 100 shown here

  1. ncbi Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling
    Shingo Mutoh
    Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Sci Signal 6:ra31. 2013
    b>Phenobarbital is a central nervous system depressant that also indirectly activates nuclear receptor constitutive active androstane receptor (CAR), which promotes drug and energy metabolism, as well as cell growth (and death), in the ..
  2. ncbi The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice
    Yukio Yamamoto
    Laboratories of Reproductive and Developmental Toxicology and Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, Research TrianglePark, NC, USA
    Cancer Res 64:7197-200. 2004
    Hepatocellular carcinoma (HCC) is known to progress through a step often called tumor promotion. Phenobarbital (PB) is the prototype of nongenotoxic cacinogens that promote HCC in rodents...
  3. ncbi A comparison of Drosophila melanogaster detoxification gene induction responses for six insecticides, caffeine and phenobarbital
    Lee Willoughby
    Centre for Environmental Stress and Adaptation Research CESAR, Department of Genetics, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010, Australia
    Insect Biochem Mol Biol 36:934-42. 2006
    ..in contrast to induction responses we observed for the natural plant compound caffeine and the barbituate drug phenobarbital, both of which highly induced a number of P450 and GST genes under the same short exposure regime...
  4. ncbi Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors
    H Aydinlik
    , , Wilhelmstr. 56, , Germany
    Oncogene 20:7812-6. 2001
    ..b>Phenobarbital (PB) is an antiepileptic drug which promotes hepatocarcinogenesis in rodents when administered subsequent to ..
  5. ncbi P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats
    Heidrun Potschka
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Bunteweg 17, D 30559, Hannover, Germany
    Neurosci Lett 327:173-6. 2002
    ..In the present study, the effect of PGP inhibition by verapamil on brain access of the AEDs phenobarbital, lamotrigine, and felbamate was investigated by in vivo microdialysis in rats...
  6. ncbi Cell shape, cell-cell contact, cell-extracellular matrix contact and cell polarity are all required for the maximum induction of CYP2B1 and CYP2B2 gene expression by phenobarbital in adult rat cultured hepatocytes
    Hiroaki Oda
    Laboratory of Nutritional Biochemistry, Department of Applied Molecular Biosciences, Nagoya University, Nagoya 464 8601, Japan
    Biochem Pharmacol 75:1209-17. 2008
    The effect of cell shape, cell density, contact with extracellular matrix and cell polarity on the phenobarbital (PB)-induced gene expression of CYP2B1 and CYP2B2 (CYP2B1/2B2) in adult rat hepatocytes was investigated...
  7. ncbi Comparison of phenobarbital with bromide as a first-choice antiepileptic drug for treatment of epilepsy in dogs
    Dawn Merton Boothe
    Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    J Am Vet Med Assoc 240:1073-83. 2012
    To compare efficacy and safety of treatment with phenobarbital or bromide as the first-choice antiepileptic drug (AED) in dogs.
  8. pmc β-Catenin loss in hepatocytes promotes hepatocellular cancer after diethylnitrosamine and phenobarbital administration to mice
    Prince Kwaku Awuah
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e39771. 2012
    ..Administration of phenobarbital (PB) containing water (0...
  9. ncbi Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21(WAF1/Cip1), cyclin D1 and Ogg1
    Anna Kinoshita
    First Department of Pathology, Osaka City University Medical School, Abeno Ku, Asahi machi 1 4 3, Osaka 545 8585, Japan
    Carcinogenesis 23:341-9. 2002
    ..and alteration to cellular proliferation and apoptosis in the rat liver were investigated during 2 weeks of phenobarbital (PB) administration at a dose of 0.05%...
  10. pmc Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver
    John P Thomson
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK
    Nucleic Acids Res 41:5639-54. 2013
    ..with short (1 day) and prolonged (7, 28 and 91 days) exposure to the rodent liver non-genotoxic carcinogen, phenobarbital (PB)...
  11. ncbi Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital
    Sandra Loeppen
    Institut fur Toxikologie, Universitat Tubingen, Germany
    Cancer Res 62:5685-8. 2002
    b>Phenobarbital (PB) is an antiepileptic drug that promotes hepatocarcinogenesis in rodents when administered subsequent to an initiating carcinogen like N-nitrosodiethylamine (DEN)...
  12. ncbi The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
    T Sueyoshi
    Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 274:6043-6. 1999
    The endogenous CYP2B6 gene becomes phenobarbital (PB) inducible in androstenol-treated HepG2 cells either transiently or stably transfected with a nuclear receptor CAR expression vector...
  13. pmc Antiepileptic drugs and apoptotic neurodegeneration in the developing brain
    Petra Bittigau
    Department of Pediatric Neurology, Children s Hospital, Charite Virchow Clinics, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Proc Natl Acad Sci U S A 99:15089-94. 2002
    ..The cause of unwanted effects of therapy with AEDs is unknown. Here we reveal that phenytoin, phenobarbital, diazepam, clonazepam, vigabatrin, and valproate cause apoptotic neurodegeneration in the developing rat brain ..
  14. pmc Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures
    Joseph Glykys
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02144, USA
    Neuron 63:657-72. 2009
    ..Uncoupling increases after treatment with Phenobarbital, which enhances the GABA(A) receptor (GABA(A)R) conductance...
  15. ncbi Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy
    Claudia Brandt
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, D 30559 Hannover, Germany
    J Neurosci 30:8602-12. 2010
    ..The antiepileptic drug phenobarbital, either alone or in combination, was used for comparison...
  16. ncbi Inducibility of the Drosophila melanogaster cytochrome P450 gene, CYP6A2, by phenobarbital in insecticide susceptible or resistant strains
    A Brun
    Laboratoire de Biologie des Invertébrés, Institut National de la Recherche, Antibes, France
    Insect Biochem Mol Biol 26:697-703. 1996
    ..the expression of this cytochrome P450 gene in the Canton(s) strain (wild type) to be under the control of phenobarbital. In adults treated with phenobarbital, this gene is transcribed in the midgut, the pericuticular fat bodies ..
  17. ncbi Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes
    P Honkakoski
    Pharmacogenectics Section, Laboratory of Reproductive and Development Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 271:9746-53. 1996
    The mouse phenobarbital (PB)-inducible Cyp2b10 gene promoter has been isolated and sequenced, and control of its expression has been characterized...
  18. pmc Treatment with phenobarbital and monitoring of epileptic patients in rural Mali
    K Nimaga
    Sante Sud, Bamako, Mali
    Bull World Health Organ 80:532-7. 2002
    To assess the efficacy of phenobarbital treatment for epileptic patients in rural Mali.
  19. pmc A physiological role of AMP-activated protein kinase in phenobarbital-mediated constitutive androstane receptor activation and CYP2B induction
    Sawako Shindo
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa, Tokyo 142 8555, Japan
    Biochem J 401:735-41. 2007
    ..It has been reported recently that AMPK (AMP-activated protein kinase) is involved in phenobarbital-mediated CYP2B induction in a particular culture system...
  20. ncbi Mimicry in primary rat hepatocyte cultures of the in vivo perivenous induction by phenobarbital of cytochrome P-450 2B1 mRNA: role of epidermal growth factor and perivenous oxygen tension
    T Kietzmann
    Institut fur Biochemie und Molekulare Zellbiologie, Gottingen, Germany
    Mol Pharmacol 56:46-53. 1999
    Treatment of male rats with phenobarbital (PB) results in a perivenous and mid-zonal pattern of cytochrome P-450 (CYP)2B1 mRNA expression within the liver acinus. The mechanism of this zonated induction is still poorly understood...
  21. ncbi Availability and costs of antiepileptic drugs and quality of phenobarbital in Vientiane municipality, Lao PDR
    Peter Odermatt
    Institut de la Francophonie pour la Médecine Tropicale, Vientiane, Lao PDR
    Neuroepidemiology 28:169-74. 2007
    ..This study investigated the availability and costs of antiepileptic drugs (AEDs), and the quality of phenobarbital in Vientiane Municipality, Lao PDR.
  22. ncbi Phenobarbital response elements of cytochrome P450 genes and nuclear receptors
    T Sueyoshi
    Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Annu Rev Pharmacol Toxicol 41:123-43. 2001
    b>Phenobarbital (PB) response elements are composed of various nuclear receptor (NR)-binding sites...
  23. ncbi Role for mitogen-activated protein kinases in phenobarbital-induced expression of cytochrome P450 2B in primary cultures of rat hepatocytes
    Florence Joannard
    INSERM UMR 620, Faculte de Pharmacie, Universite Rennes 1, 2 av Prof Léon Bernard, 35043 Rennes Cedex, France
    Toxicol Lett 161:61-72. 2006
    b>Phenobarbital (PB) alters expression of numerous hepatic genes, including genes of cytochrome P450 2B1 and 2B2 (CYP2B). However, the intracellular mechanisms remain to be fully elucidated...
  24. ncbi Striking differences in individual anticonvulsant response to phenobarbital in rats with spontaneous seizures after status epilepticus
    Claudia Brandt
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Epilepsia 45:1488-97. 2004
    ..In the present study, we used a post-status epilepticus model of TLE to examine whether rats with spontaneous recurrent seizures (SRSs) differ in their individual responses to phenobarbital (PB).
  25. ncbi Modulation of mouse and human phenobarbital-responsive enhancer module by nuclear receptors
    Janne Mäkinen
    Department of Pharmaceutics, University of Kuopio, Kuopio, Finland
    Mol Pharmacol 62:366-78. 2002
    ..CAR) regulates mouse and human CYP2B genes through binding to the direct repeat-4 (DR4) motifs present in the phenobarbital-responsive enhancer module (PBREM)...
  26. pmc Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3)
    Shingo Mutoh
    Laboratories of Reproductive and Developmental Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 284:34785-92. 2009
    ..using an anti-phospho-threonine 38 peptide antibody has, in fact, demonstrated that the classic CAR activator phenobarbital dephosphorylates the corresponding threonine 48 of mouse CAR in the cytoplasm of mouse liver and translocates ..
  27. ncbi Pregabalin as an adjunct to phenobarbital, potassium bromide, or a combination of phenobarbital and potassium bromide for treatment of dogs with suspected idiopathic epilepsy
    Curtis W Dewey
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Am Vet Med Assoc 235:1442-9. 2009
    To assess tolerability and short-term efficacy of oral administration of pregabalin as an adjunct to phenobarbital, potassium bromide, or a combination of phenobarbital and potassium bromide for treatment of dogs with poorly controlled ..
  28. ncbi Comparison of the in vitro mutagenicity and metabolism of dimethylnitrosamine and benzo[a]pyrene in tissues from inbred mice treated with phenobarbital, 3-methylcholanthrene or polychlorinated biphenyls
    J J Hutton
    Mutat Res 66:75-94. 1979
    ..of strains CF1, AKR/J, AU/SsJ, DBA/2J, SWR/J, A/J, C3H/HeJ, and C57BL/6J were either untreated or received phenobarbital (PB), 3-methylcholanthrene (MC) or polychlorinated biphenyls (AR) to induce drug-metabolizing enzymes...
  29. ncbi Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen), and phenobarbital in human volunteers
    Graham Lappin
    Xceleron Ltd, The Biocentre, Innovation Way, York YO10 5NY, UK
    Eur J Pharm Sci 43:141-50. 2011
    ..PK) following a therapeutic dose of clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen) and phenobarbital, both within the study and by reference to the existing literature on these compounds and to explore the ..
  30. ncbi Tumor formation in liver of conditional β-catenin-deficient mice exposed to a diethylnitrosamine/phenobarbital tumor promotion regimen
    Benjamin Rignall
    Department of Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Tubingen, Germany
    Carcinogenesis 32:52-7. 2011
    The antiepileptic drug phenobarbital (PB) is a potent tumor promoter in mouse liver, where it stimulates the selective outgrowth of tumor populations harboring activating mutations in Ctnnb1, encoding β-catenin...
  31. ncbi Pharmacokinetics and clinical efficacy of phenobarbital in asphyxiated newborns treated with hypothermia: a thermopharmacological approach
    M P H van den Broek
    Division of Laboratory Medicine and Pharmacy, Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Pharmacokinet 51:671-9. 2012
    ..We studied the effect of therapeutic hypothermia on the pharmacokinetics of phenobarbital in asphyxiated neonates, and the clinical efficacy and the effect of phenobarbital on the continuous amplitude-..
  32. pmc Neonatal exposure to phenobarbital potentiates schizophrenia-like behavioral outcomes in the rat
    S K Bhardwaj
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Neuropharmacology 62:2337-45. 2012
    ..However, because early-life seizures are commonly treated with antiepileptic drugs (AEDs) such as phenobarbital, the possibility that drug treatment may affect later-life psychiatric outcomes needs to be evaluated...
  33. ncbi Activation of beta-catenin provides proliferative and invasive advantages in c-myc/TGF-alpha hepatocarcinogenesis promoted by phenobarbital
    Diego F Calvisi
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4262, USA
    Carcinogenesis 25:901-8. 2004
    Previously, we have found that phenobarbital (PB) enhanced cell survival and facilitated tumor growth in our c-myc/transforming growth factor (TGF)-alpha transgenic mouse model of liver cancer...
  34. pmc Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B
    Yukio Yamamoto
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 5:e10121. 2010
    b>Phenobarbital (PB) is the most well-known among numerous non-genotoxic carcinogens that cause the development of hepatocellular carcinoma (HCC)...
  35. ncbi Phenobarbital/Lamotrigine coadministration-induced blood dyscrasia in a patient with epilepsy
    Antonio Siniscalchi
    Neurology Division, Annunziata Hospital, Cosenza, Italy
    Ann Pharmacother 44:2031-4. 2010
    To report on a patient with epilepsy who developed leukopenia and thrombocytopenia during phenobarbital/lamotrigine treatment.
  36. ncbi Differential induction of glutathione S-transferase subunits by phenobarbital, 3-methylcholanthrene and ethoxyquin in rat liver and kidney
    M Derbel
    Laboratory of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University, Japan
    Biochim Biophys Acta 1158:175-80. 1993
    The inducibility of Glutathione S-transferase (GST) in male Sprague-Dawley rats, treated with phenobarbital (PB), 3-methyl-cholanthrene (MC) and ethoxyquin (ETQ), was examined in detail...
  37. pmc Phenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice
    Harri Lempiäinen
    Investigative Toxicology, Preclinical Safety, Translational Sciences, Novartis Institutes for BioMedical Research, Basel, Switzerland
    PLoS ONE 6:e18216. 2011
    ..Here, we evaluate the sensitivity and specificity of genome-wide epigenomic and transcriptomic profiling in phenobarbital (PB)-treated B6C3F1 mice, a well-characterized rodent model of non-genotoxic liver carcinogenesis...
  38. ncbi Genome-wide analysis of phenobarbital-inducible genes in Drosophila melanogaster
    W Sun
    Department of Entomology, Purdue University, West Lafayette, IN 47907 1158, USA
    Insect Mol Biol 15:455-64. 2006
    An oligoarray analysis was conducted to determine the differential expression of genes due to phenobarbital exposure in Drosophila melanogaster (w(1118) strain) third instar larvae...
  39. ncbi The effects of carbamazepine, valproic acid and phenobarbital on the oxidative and antioxidative balance in epileptic children
    Ali Aycicek
    Sanliurfa Children s Hospital, Sanliurfa, Turkey
    Eur Neurol 57:65-9. 2007
    ..We studied the effect of antiepileptic monotherapy on serum level of total antioxidant capacity, lipid hydroperoxide, total peroxide, oxidative stress index, and individual serum antioxidants such as albumin, bilirubin and uric acid...
  40. ncbi Effects of lamotrigine alone and in combination with MK-801, phenobarbital, or phenytoin on cell death in the neonatal rat brain
    Irina Katz
    Departments of Pediatrics, Georgetown University, Washington, DC 20057, USA
    J Pharmacol Exp Ther 322:494-500. 2007
    ..This study evaluated lamotrigine alone or in combination with phenobarbital, phenytoin, or the glutamate antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine ..
  41. ncbi Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment
    Hao Xiong
    Division of Drug Delivery and Disposition, School of Pharmacy, CB 7360, Beard Hall, University of North Carolina, Chapel Hill, North Carolina 27599 7360, USA
    Drug Metab Dispos 30:962-9. 2002
    Previous studies have demonstrated that phenobarbital (PB) significantly impairs the biliary excretion of acetaminophen glucuronide (AG) in rats...
  42. ncbi Neuronal chloride accumulation and excitatory GABA underlie aggravation of neonatal epileptiform activities by phenobarbital
    Romain Nardou
    INSERM U 901, Marseille, 13009, France
    Brain 134:987-1002. 2011
    b>Phenobarbital produces its anti-epileptic actions by increasing the inhibitory drive of γ-aminobutyric acid...
  43. ncbi Bumetanide enhances phenobarbital efficacy in a neonatal seizure model
    Volodymyr I Dzhala
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 63:222-35. 2008
    ..to a greater seizure propensity and poor electroencephalographic response to GABAergic anticonvulsants such as phenobarbital and benzodiazepines...
  44. ncbi Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo
    Jillian Ross
    CXR Biosciences Ltd, 2 James Lindsay Place, Dundee DD1 5JJ, UK
    Toxicol Sci 116:452-66. 2010
    Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia. Increased cell proliferation is implicated in the mechanism of tumor induction...
  45. ncbi Enhanced biosynthetic gene expressions and production of ganoderic acids in static liquid culture of Ganoderma lucidum under phenobarbital induction
    Cui Xia Liang
    Molecular Biochemical Engineering Group, Key Laboratory of Microbial Metabolism Ministry of Education, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai, 200240, China
    Appl Microbiol Biotechnol 86:1367-74. 2010
    ..In this work, the addition of phenobarbital, a P450 inducer, was used to enhance the production of total and individual ganoderic acids in a two-stage ..
  46. ncbi Phenobarbital compared with phenytoin for the treatment of neonatal seizures
    M J Painter
    Department of Pediatrics and Neurology, University of Pittsburgh, Children s Hospital of Pittsburgh, PA 15213, USA
    N Engl J Med 341:485-9. 1999
    Seizures occur in 1 to 2 percent of neonates admitted to an intensive care unit. The treatment is usually with either phenobarbital or phenytoin, but the efficacy of the two drugs has not been compared directly.
  47. pmc Phenobarbital augments hypothermic neuroprotection
    John D Barks
    Departments of Pediatrics and Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Pediatr Res 67:532-7. 2010
    ..We hypothesized that early administration of the anticonvulsant phenobarbital after cerebral hypoxia ischemia could enhance the neuroprotective efficacy of delayed-onset hypothermia...
  48. ncbi Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis
    Jennifer M Phillips
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 96:72-82. 2007
    ..mechanism that plays a key role in the carcinogenesis process, and the nongenotoxic rodent hepatocarcinogen phenobarbital (PB) alters the methylation status of DNA in mouse liver...
  49. ncbi The Drosophila cytochrome P450 gene Cyp6a2: structure, localization, heterologous expression, and induction by phenobarbital
    B C Dunkov
    Department of Entomology, University of Arizona, Tucson 85721 0036, USA
    DNA Cell Biol 16:1345-56. 1997
    ..b>Phenobarbital treatment of flies leads to a rapid increase in the level of CYP6A2 mRNA and to an increased production of the ..
  50. ncbi Phenobarbital for the treatment of epilepsy in the 21st century: a critical review
    Patrick Kwan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Epilepsia 45:1141-9. 2004
    Summary: Phenobarbital (PB) is the most widely used antiepileptic drug (AED) in the developing world and remains a popular choice in many industrialized countries...
  51. pmc The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors
    Jennifer M Phillips
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 110:319-33. 2009
    ..is to elucidate progressive changes, in expression and methylation status, of genes which play key roles in phenobarbital (PB)-induced liver tumorigenesis, with an emphasis on their potential to affect signaling through critical ..
  52. ncbi Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid
    Christian Hocht
    Catedra de Farmacologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, C1113AAD Buenos Aires, Argentina
    Neurosci Lett 453:54-7. 2009
    ..The aim of the present work was to assess the involvement of P-glycoprotein in carbamazepine and phenobarbital hippocampal pharmacokinetics in an experimental model of epilepsy, induced by repetitive MP administration...
  53. ncbi Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor
    Yuping Chen
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 308:495-501. 2004
    ..Several studies have reported that certain drugs such as rifampicin and phenobarbital induce CYP2C9, but the molecular basis for this induction remains unknown...
  54. ncbi Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital
    Kouichi Yoshinari
    Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    FEBS Lett 548:17-20. 2003
    The nuclear receptor CAR, a phenobarbital (PB)-responsive transcription factor, translocates into the nucleus of hepatocytes after PB induction...
  55. pmc A KCNQ channel opener for experimental neonatal seizures and status epilepticus
    YogendraSinh H Raol
    Division of Neurology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Ann Neurol 65:326-36. 2009
    ..This study tests the hypothesis that selective openers of KCNQ channels may be effective for treatment of neonatal seizures...
  56. ncbi Generation-dependent encapsulation/electrostatic attachment of phenobarbital molecules by poly(amidoamine) dendrimers: Evidence from 2D-NOESY investigations
    Yiyun Cheng
    Laboratory of Functional Membranes, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China
    Eur J Med Chem 44:2219-23. 2009
    The interactions of phenobarbital with different generations of amine-terminated poly(amidoamine) (PAMAM) dendrimers were investigated by using two dimensional-nuclear Overhauser effect spectroscopic (2D-NOESY) investigations...
  57. ncbi Involvement of phenobarbital and SKF 525A in the hepatotoxicity of antifungal drugs itraconazole and fluconazole in rats
    N Somchit
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
    Drug Chem Toxicol 29:237-53. 2006
    ..The purpose of this study was to investigate the role of phenobarbital (PB), an inducer of cytochrome P450 (CYP), and SKF 525A, an inhibitor of CYP, in the mechanism of ..
  58. ncbi Phenobarbital induces progressive patterns of GC-rich and gene-specific altered DNA methylation in the liver of tumor-prone B6C3F1 mice
    Ammie N Bachman
    Department of Pharmacology and Toxicology and Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 91:393-405. 2006
    Altered DNA methylation contributes to tumorigenesis by affecting gene expression in a heritable fashion. Phenobarbital (PB) is a nongenotoxic rodent carcinogen which induces global hypomethylation and regions of hypermethylation in ..
  59. ncbi Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells
    Carine B Lambert
    INSERM U620 and Université de Rennes 1, 35043 Rennes, France
    Toxicol Appl Pharmacol 234:345-60. 2009
    b>Phenobarbital (PB) induces or represses a wide spectrum of genes in rodent liver. Much less is known about its effects in human liver...
  60. pmc Side effects of phenobarbital and carbamazepine in childhood epilepsy: randomised controlled trial
    Selina H Banu
    Child Development and Neurology Unit, Dhaka Shishu Children s Hospital, Bangladesh Institute of Child Health, Sher E Bangla Nagar, Dhaka 1207, Bangladesh
    BMJ 334:1207. 2007
    To compare the behavioural side effects associated with two commonly used antiepilepsy drugs-phenobarbital and carbamazepine-in children in Bangladesh.
  61. pmc Inhibitory effect of vanadium on rat liver carcinogenesis initiated with diethylnitrosamine and promoted by phenobarbital
    A Bishayee
    Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India
    Br J Cancer 71:1214-20. 1995
    ..by a single intraperitoneal injection of diethylnitrosamine (DENA; 200 mg kg-1) followed by promotion with phenobarbital (0.05%) in the diet. Supplementary vanadium (0.5 p.p.m...
  62. ncbi Clinical pharmacokinetics of phenobarbital in neonates
    D J Touw
    Department of Pharmacy, Vrije Universiteit Medical Centre, De Boelelaan 1117, NL 1081 HV, Amsterdam, The Netherlands
    Eur J Pharm Sci 12:111-6. 2000
    ..and clinical pharmacokinetic data collected from term and preterm neonates who were treated with intravenous phenobarbital have been analysed to evaluate the role of patient characteristics in pharmacokinetic parameters...
  63. ncbi Differential display in rat livers treated for 13 weeks with phenobarbital implicates a role for metabolic and oxidative stress in nongenotoxic carcinogenicity
    Mollisa M Elrick
    Pfizer Corporation, Worldwide Safety Sciences, St Louis, Missouri 63167, USA
    Toxicol Pathol 33:118-26. 2005
    Hepatic enzyme inducers such as phenobarbital are often nongenotoxic rodent hepatocarcinogens. Currently, nongenotoxic hepatocarcinogens can only be definitively identified through costly and extensive long-term, repeat-dose studies (e.g...
  64. ncbi Antiepileptic drug-resistant rats differ from drug-responsive rats in hippocampal neurodegeneration and GABA(A) receptor ligand binding in a model of temporal lobe epilepsy
    Holger A Volk
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Hannover, Germany
    Neurobiol Dis 21:633-46. 2006
    ..these seizures was recorded by continuous video/EEG monitoring before, during, and after daily treatment with phenobarbital, which was given at maximum tolerated doses for 2 weeks...
  65. ncbi Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model
    Monika Dudra-Jastrzebska
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Seizure 18:607-14. 2009
    ..levetiracetam (LEV) and the conventional antiepileptic drugs (AEDs) clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced clonic seizures in mice by use of ..
  66. ncbi Phenobarbital responsiveness as a uniquely sensitive indicator of hepatocyte differentiation status: requirement of dexamethasone and extracellular matrix in establishing the functional integrity of cultured primary rat hepatocytes
    Jaspreet S Sidhu
    Department of Environmental Health, University of Washington, Seattle, WA 98105, USA
    Exp Cell Res 292:252-64. 2004
    ..extracellular matrix (ECM) coordinate cell differentiation and transcriptional responsiveness to the inducer, phenobarbital (PB)...
  67. ncbi Efficacy of clonidine versus phenobarbital in reducing neonatal morphine sulfate therapy days for neonatal abstinence syndrome. A prospective randomized clinical trial
    B Surran
    1 Division of Newborn Medicine, Baystate Children s Hospital, Springfield, MA, USA 2 Department of Neurology, Boston Medical Center, Boston, MA, USA
    J Perinatol 33:954-9. 2013
    To compare the efficacy of clonidine versus phenobarbital in reducing morphine sulfate treatment days for neonatal abstinence syndrome (NAS).
  68. ncbi Sequence of a chicken phenobarbital-inducible cytochrome P450 cDNA: regulation of two P450 mRNAs transcribed from different genes
    A J Hansen
    Department of Biochemistry, University of Adelaide, South Australia
    DNA 8:179-91. 1989
    The nucleic acid and derived amino acid sequences of a chicken phenobarbital-inducible cytochrome P450 cDNA clone, pCHP7, are presented...
  69. ncbi Differential inhibitory effects of thiopental, thiamylal and phenobarbital on both voltage-gated calcium channels and NMDA receptors in rat hippocampal slices
    R Z Zhan
    Department of Anaesthesiology, Niigata University School of Medicine, Japan
    Br J Anaesth 81:932-9. 1998
    ..We have compared the effects of thiopental, thiamylal and phenobarbital on both voltage-gated calcium channels (VGCC) and N-methyl-D-aspartate (NMDA) receptors in rat hippocampal ..
  70. ncbi Functional analysis of the cis-acting elements responsible for the induction of the Cyp6a8 and Cyp6g1 genes of Drosophila melanogaster by DDT, phenobarbital and caffeine
    R Morra
    Department of Biology, Emory University, Atlanta, GA, USA
    Insect Mol Biol 19:121-30. 2010
    Many Drosophila cytochrome P450 or Cyp genes are induced by caffeine and phenobarbital (PB)...
  71. pmc Hormone receptor-like in 96 and Broad-Complex modulate phenobarbital induced transcription of cytochrome P450 CYP6D1 in Drosophila S2 cells
    G G H Lin
    Department of Entomology, Comstock Hall, Cornell University, Ithaca, NY 14853, USA
    Insect Mol Biol 20:87-95. 2011
    b>Phenobarbital (PB) is a prototypical inducer for studies of xenobiotic responses in animals...
  72. ncbi Dupuytren's contracture as result of prolonged administration of phenobarbital
    M Tripoli
    Reconstructive and Plastic Surgery, Dipartimento di Discipline Chirurgiche ed Oncologiche, Palermo University, Italy
    Eur Rev Med Pharmacol Sci 15:299-302. 2011
    ..In literature, there are different opinions regarding the phenobarbital, a common antiepileptic drug, and its effective role in the genesis and development of Dupuytren's disease...
  73. ncbi P-glycoprotein-mediated efflux of phenobarbital at the blood-brain barrier evidence from transport experiments in vitro
    Zhi Hong Yang
    Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    Epilepsy Res 78:40-9. 2008
    The purpose of the present studies was to investigate characteristics of phenobarbital (PB) transport across the blood-brain barrier (BBB). Cultured rat brain microvascular endothelial cells (rBMECs) were used as an in vitro BBB model...
  74. pmc The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver
    Yoshihiro Konno
    Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Drug Metab Dispos 38:1177-82. 2010
    ..We have now found that CYP2C55 is induced by phenobarbital (PB) and pregnenolone 16alpha-carbonitrile (PCN) in both mouse kidney and liver...
  75. ncbi Midazolam in neonatal seizures with no response to phenobarbital
    J R Castro Conde
    Neonatology Service, University Hospital of the Canary Islands, Ofra s n, La Laguna 28230, Spain
    Neurology 64:876-9. 2005
    ..ESz persisted in 17 of 32 neonates receiving phenobarbital/phenytoin (13 had a poor outcome, 4 died)...
  76. ncbi Side effects of phenobarbital in epilepsy: a systematic review
    Ling Li Zhang
    Department of Pharmacy, West China Second University Hospital, China
    Epileptic Disord 13:349-65. 2011
    In recent years, phenobarbital, as an antiepileptic drug, has become less popular based on adverse events, especially cognitive and behavioural side effects...
  77. ncbi EEG wavelet analyses of the striatum-substantia nigra pars reticulata-superior colliculus circuitry: audiogenic seizures and anticonvulsant drug administration in Wistar audiogenic rats (War strain)
    Franco Rossetti
    Physiology Department, Ribeirao Preto School of Medicine, University of Sao Paulo, Avenida Bandeirantes 3900, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
    Epilepsy Res 72:192-208. 2006
    ..and electroencephalographic (EEG) data were collected from WARs under no treatment or injection with systemic (phenobarbital) or intracerebral (intranigral) drugs (muscimol and phenobarbital)...
  78. ncbi In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoprotein
    Chunbo Zhang
    School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Life Sci 86:899-905. 2010
    ..We evaluated AEDs as P-gp substrates using cell monolayers...
  79. ncbi HPLC assay of acetylsalicylic acid, paracetamol, caffeine and phenobarbital in tablets
    J T Franeta
    Department of Pharmaceutical Chemistry and Drug Analysis, Faculty of Pharmacy, Belgrade, Serbia, Yugoslavia
    Farmaco 57:709-13. 2002
    ..paper present a HPLC method for simultaneous determination of acetylsalicylic acid, paracetamol, caffeine and phenobarbital in tablets, using chromatographic system consisting a Bio Rad 18 01 solvent pump, Rheodine 71 25 injector and ..
  80. ncbi Transcriptional activation of PPARalpha by phenobarbital in the absence of CAR and PXR
    Viola Tamasi
    Genome Scale Biology, Biozentrum, University of Basel, Basel, Switzerland
    Mol Pharm 6:1573-81. 2009
    ..nuclear receptors CAR (constitutive androstane receptor) and PXR (pregnane X receptor) mediate the effects of phenobarbital on gene transcription...
  81. ncbi Effects of phenobarbital and multiple-dose corticosteroids on developmental outcome at age 7 years
    James A Thorp
    Regional Perinatal Center, Sacred Heart Women s Hospital, Pensacola, Florida 32513, USA
    Obstet Gynecol 101:363-73. 2003
    To determine the effects of phenobarbital and repeated antenatal steroid use on the primary outcome (intelligence and achievement) and secondary outcomes (behavior and head circumference) at age 7 years.
  82. ncbi [Pigmented hepatocellular adenoma of the liver caused by long-term use of phenobarbital]
    A Ferko
    Katedra válecné chirurgie, Vojenská lékarská akademie Jana Evangelisty Purkynĕ v Hradci Králové
    Rozhl Chir 82:192-5. 2003
    ..The authors discuss the possible development of adenomas of the liver as a result of long-term use of phenobarbital. As a basis they use experimental observations where this drug acts as a strong promotor of DNA synthesis and ..
  83. ncbi Quality of phenobarbital solid-dosage forms in the urban community of Nouakchott (Mauritania)
    Marie Laure Laroche
    Institute of Neuroepidemiology and Tropical Neurology EA 3174, Faculty of Medicine, Limoges, France
    Epilepsia 46:1293-6. 2005
    ..The aim of this study was to describe the proportion of poor-quality phenobarbital (PB) solid-dosage forms and evaluate the factors associated with its quality in Nouakchott (Mauritania).
  84. ncbi Bumetanide augments the neuroprotective efficacy of phenobarbital plus hypothermia in a neonatal hypoxia-ischemia model
    YiQing Liu
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA
    Pediatr Res 71:559-65. 2012
    ..a clinically available diuretic, inhibits this chloride transporter and augments the antiepileptic effects of phenobarbital (PB) in neonatal rodents...
  85. ncbi Microdialysis sampling of carbamazepine, phenytoin and phenobarbital in subcutaneous extracellular fluid and subdural cerebrospinal fluid in humans: an in vitro and in vivo study of adsorption to the sampling device
    Martin Lindberger
    Department of Neurology, Karolinska Institute, Huddinge University Hospital, S 14186 Huddinge, Sweden
    Pharmacol Toxicol 91:158-65. 2002
    ..to the sampling equipment during microdialysis would influence the results for carbamazepine, phenytoin and phenobarbital. In vitro experiments with microdialysis catheters and separate parts of catheters were performed to estimate ..
  86. ncbi The antiepileptic drugs phenobarbital and carbamazepine reduce transport of methotrexate in rat choroid plexus by down-regulation of the reduced folate carrier
    Sandra Halwachs
    Institute of Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, An den Tierkliniken 15, University of Leipzig, 04103 Leipzig, Germany
    Mol Pharmacol 80:621-9. 2011
    ..MTX neurotoxicity usually manifests as seizures requiring therapy with antiepileptic drugs (AEDs) such as phenobarbital (PB)...
  87. ncbi Characterization of drug-specific T cells in phenobarbital-induced eruption
    Hideo Hashizume
    Department of Dermatology, Hamamatsu University School of Medicine, 1 20 1 Handa yama, Hamamatsu 431 3192, Japan
    J Immunol 168:5359-68. 2002
    b>Phenobarbital has a high potential to elicit adverse reactions including severe skin eruptions and systemic involvements among the worldwide-prescribed drugs...
  88. ncbi Multiple organ toxicity, including hypochromic anemia, following repeated dose oral administration of phenobarbital (PB) in rats
    Sayuri Kojima
    The Institute of Environmental Toxicology, Joso shi, Ibaraki, Japan
    J Toxicol Sci 34:527-39. 2009
    A 4-week repeated dose oral toxicity study of phenobarbital (PB) sodium was conducted in F344 rats of both sexes at PB doses of 0.8, 8, and 80 mg/kg/day to fully elucidate its general toxicity including hematological changes...
  89. ncbi Acute exposure to caffeine decreases the anticonvulsant action of ethosuximide, but not that of clonazepam, phenobarbital and valproate against pentetrazole-induced seizures in mice
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 58:652-9. 2006
    ..anticonvulsant action of four conventional antiepileptic drugs (AEDs: clonazepam - CZP, ethosuximide - ETS, phenobarbital - PB and valproate - VPA) against pentetrazole (PTZ)-induced clonic seizures in mice...
  90. ncbi Induction of cytochrome P450 isozymes by phenobarbital in pregnant rat and fetal livers and placenta
    Noriko Ejiri
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Exp Mol Pathol 78:150-5. 2005
    ..in the expression of CYP proteins in the pregnant rat and fetal livers and placenta after treatment with phenobarbital (PB), one of the antiepileptic drugs which is well known to induce several phase I and phase II drug ..
  91. ncbi Validation of (-)-N-3-benzyl-phenobarbital as a selective inhibitor of CYP2C19 in human liver microsomes
    Xiaoxin Cai
    Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Drug Metab Dispos 32:584-6. 2004
    N-3-Benzyl-phenobarbital (NBPB) was reported to be a potent and selective inhibitor of CYP2C19...
  92. ncbi Transcriptional activation of cytochrome P450 CYP2C45 by drugs is mediated by the chicken xenobiotic receptor (CXR) interacting with a phenobarbital response enhancer unit
    Manuel Baader
    Department of Pharmacology Neurobiology, Biozentrum of the University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    J Biol Chem 277:15647-53. 2002
    ..6 kb of its 5'-flanking region. Exposure of LMH cells to phenobarbital or metyrapone led to a 95- or 210-fold increase in CYP2C45 mRNA and a 140- or 290-fold increase in reporter ..
  93. ncbi Induction of hepatic cytochrome P-450 by phenobarbital in semi-aquatic frog (Rana pipiens)
    M A Khan
    Department of Biological Sciences, University of Illinois at Chicago 60607 7060, USA
    Biochem Biophys Res Commun 244:737-44. 1998
    ..It is hypothesized that the evolution of true terrestrialness, and not the evolution of air-breathing lungs alone, is required for the transcriptional activation of CYPIIB gene by PB...
  94. ncbi Chromatin assembly enhances binding to the CYP2B1 phenobarbital-responsive unit (PBRU) of nuclear factor-1, which binds simultaneously with constitutive androstane receptor (CAR)/retinoid X receptor (RXR) and enhances CAR/RXR-mediated activation of the PB
    J Kim
    Departments of Molecular and Integrative Physiology and Cell and Structural Biology, College of Medicine, University of Illinois at Urbana-Champaign, 61801, USA
    J Biol Chem 276:7559-67. 2001
    b>Phenobarbital induction of CYP2B genes is mediated by a complex phenobarbital-responsive enhancer (PBRU), which contains a binding site for nuclear factor-1 (NF-1) flanked by two DR-4 nuclear receptor (NR) binding sites for a heterodimer ..
  95. ncbi A randomized, triple-blind, placebo-controlled trial of prophylactic oral phenobarbital to reduce the need for phototherapy in G6PD-deficient neonates
    Srinivas Murki
    Division of Neonatology, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J Perinatol 25:325-30. 2005
    ..The role of enzyme inducers, like phenobarbital, in G6PD deficiency is unclear...
  96. ncbi Effect of the co-administration of phenobarbital, quercetin and mancozeb on nitrosomethylurea-induced pancreatic tumors in rats
    M A Valentich
    2 a Cátedra de Biología Celular, Histología y Embriología, Instituto de Biologia Celular, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    Food Chem Toxicol 44:2101-5. 2006
    ..This work studies the effect of oral administration of phenobarbital (PB) on this model of pancreatic carcinogenesis...
  97. ncbi Phenobarbital for neonatal seizures in hypoxic ischemic encephalopathy: a pharmacokinetic study during whole body hypothermia
    Luca Filippi
    Neonatal Intensive Care Unit, Department of Perinatal Medicine, A Meyer University Children s Hospital, Florence, Italy
    Epilepsia 52:794-801. 2011
    ..b>Phenobarbital is widely used to treat neonatal seizures, but it is unknown whether its pharmacokinetics is affected by ..
  98. ncbi Neonatal N-(-2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) treatment modifies the vulnerability to phenobarbital- and ethanol-evoked sedative-hypnotic effects in adult rats
    Aleksandra Bortel
    Department of Pharmacology, Medical University of Silesia, H Jordana 38, PL 41 808 Zabrze, Poland
    Pharmacol Rep 60:331-8. 2008
    ..weeks, loss of the righting reflex (LORR) was used as an index to study the acute sedative-hypnotic effects of phenobarbital (100 mg/kg ip) and ethanol (4 g/kg ip, 25% v/v)...
  99. ncbi A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line
    C Handschin
    Department of Pharmacology Neurobiology, Biozentrum of the University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Biol Chem 275:13362-9. 2000
    b>Phenobarbital-responsive DNA elements were identified in the 5'-flanking region of the chicken CYP2H1 gene by in reporter gene assays in a chicken hepatoma cell line (leghorn male hepatoma (LMH))...
  100. ncbi Congenital abnormalities of 88 children born to mothers who attempted suicide with phenobarbital during pregnany: the use of a disaster epidemiological model for the evaluation of drug teratogenicity
    Gábor Timmermann
    Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
    Pharmacoepidemiol Drug Saf 18:815-25. 2009
    To study the effect of large doses of phenobarbital used for a suicide attempt during pregnancy for fetuses to estimate the teratogenic potential of phenobarbital.
  101. ncbi Werner's syndrome helicase participates in transcription of phenobarbital-inducible CYP2B genes in rat and mouse liver
    Antoine Amaury Lachaud
    Centre de recherche en cancérologie de l Université Laval, L Hôtel Dieu de Québec, CHUQ, Quebec, Canada
    Biochem Pharmacol 79:463-70. 2010
    ..The rat CYP2B2 gene and its closely related mouse homolog, Cyp2b10, are both strongly induced in liver by phenobarbital. We found that there is phenobarbital-dependent recruitment of WRN to the promoter of the CYP2B2 gene as ..

Research Grants71

  1. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  2. Nanoparticle Coupled Antioxidants for Respiratory Illness in Veterans
    RODNEY JON SCHLOSSER; Fiscal Year: 2013
    ..We will use a murine model of allergic fungal rhinosinusitis with exacerbation by smoke or DEP exposure to determine the efficacy of antiMUC1-SOD/CAT-NPs. ..
  3. Hydrodynamic forces modulate renal tubular function
    Rajeev Rohatgi; Fiscal Year: 2012
    ....
  4. Molecular Basis of E. coli Adhesins in Bladder Disorders
    Scott J Hultgren; Fiscal Year: 2013
    ....
  5. Understanding Pain of Gastrointestinal Origin in Women that Serve in OEF/OIF
    Beverley Greenwood-Van Meerveld; Fiscal Year: 2013
    ..Moreover, we will examine whether rats exposed to ELS show altered behavioral responses to chronic stress in adulthood compared to age-matched controls ..
  6. Improved Adventitial Sirolimus Therapy for Peripheral Artery Restenosis
    KIRK SEWARD; Fiscal Year: 2010
    ....
  7. Colitis Induced by immune responses to luminal bacteria-mouse
    Ryan B Sartor; Fiscal Year: 2012
    ....
  8. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    John R Grider; Fiscal Year: 2013
    ..The results would open a new field of study and point the way to new avenues of investigation for pharmacological agents to treat diarrhea and/or constipation. ..
  9. Dietary Risk for Colon Cancer in the Mouse
    Leonard H Augenlicht; Fiscal Year: 2013
    ..abstract_text> ..
  10. MECHANISMS OF GASTROINTESTINAL GROWTH AND TRANSFORMATION
    Juanita L Merchant; Fiscal Year: 2013
    ..Collectively, these studies will establish a link between ZBP-89 and pATMS1981, in the biosynthesis and function of 5HT in response to luminal butyrate. ..
  11. Control of Drug Delivery to the CNS: Modulating P-glycoprotein Activity
    William A Banks; Fiscal Year: 2013
    ..abstract_text> ..
  12. EPICARDIAL ADIPOSE TISSUE, OBESITY AND INFLAMMATION IN ATHEROSCLEROSIS
    Devendra K Agrawal; Fiscal Year: 2013
    ..The proposed studies will provide conceptual support of our hypothesis and position us to translate our investigation into a clinical study in obese patients with coronary artery disease. ..
  13. Evaluation of novel FoxM1 inhibitors against liver cancer
    Andrei L Gartel; Fiscal Year: 2012
    ..to test the anticancer properties of the thiazole antibiotics we will use a Diethylnitrosamine (DEN)/Phenobarbital (PB) liver tumor induction protocol in male mice and a new ARF-/- Rosa-26 FoxM1b TG mouse model of aggressive ..
  14. Effect of bisphenol A exposure on mammary stem cell function and transformation
    Luzhe Sun; Fiscal Year: 2013
    ....
  15. Role of Integrins in Bladder Urothelium
    Warren G Hill; Fiscal Year: 2013
    ..This project will provide new knowledge of the mechanisms by which the bladder senses filling and responds and in so doing may suggest new therapeutic options for bladder disease. ..
  16. Redox regulation of intestinal T cells
    ALAN DAVID LEVINE; Fiscal Year: 2010
    ..We can then target this molecule for 'correction'and in the future determine whether this type of treatment is an effective therapy for mucosal infections, vaccine development, or mucosal autoimmune-like diseases. ..
  17. Probiotic-Induced Elimination of Oxalate to treat Hyperoxaluria
    Marguerite Hatch; Fiscal Year: 2013
    ..abstract_text> ..
  18. Drug Transport at the Blood-Testis Barrier
    Nathan J Cherrington; Fiscal Year: 2013
    ....
  19. Transcriptional Networks Regulating Luminal Environment in the Epididymis
    Ann Harris; Fiscal Year: 2013
    ..Through modulation of this environment we may also be able to inhibit normal sperm maturation and thereby develop novel methods of birth control. ..
  20. Role of Neutrophil-Platelet Interactions in Vascular Occlusive Disorders
    Nauder Faraday; Fiscal Year: 2010
    ....
  21. Route of Nutrition and Enteric Nervous System Effects on Innate Mucosal Defense
    Kenneth A Kudsk; Fiscal Year: 2013
    ..We expect these studies will provide advances in our understanding of mucosal defenses and be highly relevant to critically injured and critically ill Veterans. ..
  22. Developmental Physiology of Ciliated Epithelia
    CHRISTOPHER ROBERT KINTNER; Fiscal Year: 2012
    ....
  23. Central Mechanisms Modulating Visceral Sensitivity
    Beverley Greenwood-Van Meerveld; Fiscal Year: 2013
    ..Our findings may identify targets for the development of novel therapeutic strategies directed at the brain, to improve the treatment or even reduce the risk for the development of anxiety-linked visceral pain in Veterans. ..
  24. Calcium-sensing receptor signaling in the regulation of colonic epithelial cells
    JUAN ENRIQUE ROZENGURT; Fiscal Year: 2012
    ..The completion of the proposed studies will provide a robust intellectual framework for targeting the colonic CaSR in the chemoprevention of CRC in US veterans as well as in the US population at large. ..
  25. Mammary Gland Morphogenesis and Breast Cancer
    Ian G Macara; Fiscal Year: 2013
    ..We have developed methods that facilitate the rapid analysis of gene function in mammary gland development and cancer. We will use these methods to identify new cancer genes, and to understand how breast cancers develop and metastasize. ..
  26. Regulation of Intestinal Epithelial Tight Junction Barrier
    Thomas Y Ma; Fiscal Year: 2011
    ..The purpose of this grant application is to elucidate the pathogenic mechanisms involved in bacterial antigen induced disruption of intestinal barrier (or development of leaky gut). ..
  27. Targeted epigenetic therapy of triple-negative breast cancer
    Samuel Waxman; Fiscal Year: 2013
    ..Successful SID decoy development offers other therapeutic options for triple negative breast cancer and also novel drugable targets. ..
  28. Extracellular Replication of Listeria in Vivo
    Christopher H Contag; Fiscal Year: 2010
    ..We propose to use molecular imaging techniques to learn how this bacterium colonizes the gallbladder, constituting the only current animal model of the human carrier state of typhoid fever. ..
  29. Keratin Biology and Disease Aspects in Simple Epithelia
    Bishr Omary; Fiscal Year: 2013
    ..Our ultimate goal is to better understand the function of keratins and their human disease relevance in digestive organs, and to provide fundamental knowledge on how the keratins family regulates normal digestive organ physiology. ..
  30. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    JOHN GRIDER; Fiscal Year: 2009
    ..abstract_text> ..
  31. Blood Pressure Regulation: Novel Roles for the Kidney
    Pablo A Ortiz; Fiscal Year: 2013
    ..Thus it will accelerate acquisition of knowledge of the novel mechanisms by which the kidney regulates blood pressure, and may provide new targets for anti-hypertensive drugs. ..
  32. Effects of apoptotic epithelial cell engulfment on mucosal inflammation
    Peter B Ernst; Fiscal Year: 2010
    ..This new information may have therapeutic applications for the prevention or treatment of digestive diseases triggered by infection including inflammatory bowel diseases and infectious diarrhea. ..
  33. Mechanisms of abnormal enterochromaffin cell secretion in Crohn's disease
    Mark S Kidd; Fiscal Year: 2012
    ..In addition, it may provide the potential for novel therapeutic targets in Crohn's disease and possibly other forms of inflammatory bowel disease. ..
  34. Regulation of colitis by orphan nuclear receptor Nur77
    Dezheng Zhao; Fiscal Year: 2013
    ..Our studies have high impact by linking Nur77 to IBD pathogenesis and indicate vascular components of inflammation that could serve as therapeutic targets. ..
  35. Molecular Profiles and Lifestyle Factors in Breast Cancer Prognosis
    Bette J Caan; Fiscal Year: 2013
    ..This population-based cohort is uniquely positioned to address several important gaps in our knowledge about cancer survivorship. ..
  36. V-ATPase H+ PUMP REGULATION IN FUEL ENERGY SELECTION
    Karlett J Parra; Fiscal Year: 2013
    ..As pathophysiology of the glucose-fatty acid cycle results in metabolic disorders including diabetes and chronic kidney disease, our studies will also contribute towards their understanding. ..
  37. MECHANISMS OF ARTERIAL GRAFT HEALING
    Alexander W Clowes; Fiscal Year: 2013
    ....
  38. CD36 and Intestinal Fat Absorption
    Nada A Abumrad; Fiscal Year: 2013
    ..We should learn whether targeting intestinal CD36 may be beneficial in disorders like obesity, insulin resistance and gallstone formation. ..
  39. Development and Functional Analysis of Components of the Zebrafish Serotonin Sign
    Kenneth N Wallace; Fiscal Year: 2012
    ..Genetic defects identified in this research will contribute to understanding these conditions. ..
  40. Cholecystokinin - Role in postprandial gastric motility
    Helen E Raybould; Fiscal Year: 2013
    ....
  41. Milk oligosaccharides, bifidobacteria and intestinal epithelium.
    Maciej Chichlowski; Fiscal Year: 2011
    ....
  42. Regulation of Genomic Instability in Early Breast Cancer
    Thea D Tlsty; Fiscal Year: 2013
    ..abstract_text> ..
  43. Specific Contribution of a New IG Isotype (IGT) in Teleost Fish Immune Responses
    J Oriol Sunyer; Fiscal Year: 2013
    ..Therefore, a better knowledge of the fish immune system is essential to the development of new therapeutic agents and vaccines to prevent fish diseases. ..
  44. BIOCHEMISTRY AND PHYSIOLOGY OF PEPTIDE AMIDATION
    ELIZABETH ANNE EIPPER; Fiscal Year: 2013
    ..Both enzymatic activities of PAM have been extensively studied and their enzymology and biology, along with the biological consequences of inadequate ability to perform peptide amidation, form the basis of this work. ..
  45. VITAMIN D AND IMMUNOMODULATION IN CORONARY ARTERY DISEASE
    Devendra K Agrawal; Fiscal Year: 2013
    ....
  46. In vivo mechanisms of methamphetamine-induced neuronal necrosis
    Denson G Fujikawa; Fiscal Year: 2013
    ..a calpain substrate, to document calpain I activation;(5) parentera administration of diazepam and phenobarbital after METH administration to stop electrographic seizures, which we predict will also provide neuroprotection ..
  47. Effects of gastric bypass on the gut microbiota and energy balance
    Alice Liou; Fiscal Year: 2012
    ....
  48. Axial Flow Effects in Proximal Tubule
    TONG WANG WANG; Fiscal Year: 2012
    ..Possible benefits include identification of target molecules, which may be blocked or modified in order to modulate sodium reabsorption by the kidney. ..
  49. Microbial Invasion of the Intestine at the Cell Extrusion Zone of the Villus Tip
    Manuel R Amieva; Fiscal Year: 2012
    ..We propose to study a new paradigm that explains how Listeria monocytogenes, and perhaps also other invasive enteropathogens, breach the intestinal barrier. ..
  50. Intercellular networks and luminal acidification in the male reproductive tract
    Sylvie Breton; Fiscal Year: 2013
    ..Data generated here will provide novel insights into the male reproductive tract in particular, as well as the physiology of acid/base transporting epithelia in general. ..
  51. A her-2/neu Pulsed DC1 Vaccine for Patients with DCIS
    BRIAN JOSEPH CZERNIECKI; Fiscal Year: 2012
    ..It is anticipated that the production of chemokines and cytokines by DC1 will lead to accelerated accumulation of specific and non-specific effectors in the area of DCIS and further clinical responses. ..
  52. Molecular Mechanisms Regulating Intestinal Homeostasis
    Vincent W Yang; Fiscal Year: 2013
    ....
  53. Calcium Regulation in Airway Smooth Muscle
    Gary C Sieck; Fiscal Year: 2013
    ..These studies will the foundation for better understanding of airway diseases, and potential development of new therapeutic targets. ..
  54. Aldehydes in Alcohol-Induced Organ Injury
    Zhanxiang Zhou; Fiscal Year: 2013
    ..Effects of ALDH2-recombinant L. acidophilus, zinc and resveratrol on aldehyde clearance and alcohol-induced organ injury will be determined. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page ..
  55. Gut L-Histidine Metabolism and Histamine Signaling in Colonic Neoplasia
    James Versalovic; Fiscal Year: 2013
    ..These studies may point the way towards an improved understanding of how diet and the microbiome affect cancer risk in human populations. ..
  56. Embryonic Development of the Mammalian Epididymis
    Barry T Hinton; Fiscal Year: 2013
    ..Specifically they will provide an understanding as to how the regulation of growth of the epididymis during development is important clinically. ..
  57. Novel Roles of Intracrine Angiotensin II in Proximal Tubule Cells
    Jia Zhuo; Fiscal Year: 2009
    ..These studies will provide new insights into important roles of intracellular or intracrine Ang II in the regulation of salt and fluid transport in proximal tubules of the kidney and in the pathogenesis of hypertension. ..
  58. A Novel Brachytherapy Agent for GBM
    FRANK CALZONE; Fiscal Year: 2013
    ..We have assembled a unique team of experts including: a neurosurgeon, disintegrin/integrin specialist, molecular biologist, radiation oncologist, medical physicist, animal model specialist and biostatistician. ..
  59. Mechanisms of Fatty Acid Metabolism in Prostate Differentiation and Disease
    DOUGLAS WILLIAM STRAND; Fiscal Year: 2013
    ..Based on preliminary data, it is expected that prostate insulin insensitivity increases PDK4 levels and fatty acid flux, leading to hyperplasia, inflammation and resistance to therapy in BPH. ..
  60. 3-Dimensional modeling of basal cell function in pseudostratified epithelia
    Sylvie Breton; Fiscal Year: 2013
    ..abstract_text> ..
  61. Role of Human Intestinal Microbiota on Success of Surgical Weight Loss Procedures
    BRUCE EDWARD RITTMANN; Fiscal Year: 2013
    ..The ultimate goal is to find microorganisms that help weight loss following bariatric surgery. ..
  62. A Luminal Vascular Coating to Prevent Intimal Hyperplasia Following Creation of a
    Kate Stuart; Fiscal Year: 2013
    ..Successful completion of this project will lead to a potential novel therapy to reduce the incidence of failure in vascular access for hemodialysis patients ..
  63. ENDOTHELIAL INJURY AND CYTOPROTECTION
    JACK HAWIGER; Fiscal Year: 1993
    ....
  64. Novel minimally invasive assessment of gastrointestinal inflammation in food alle
    Glenn Furuta; Fiscal Year: 2009
    ....
  65. Mucus Penetrating Nanoparticles for Vaginal Drug Delivery
    Justin Hanes; Fiscal Year: 2009
    ..If successful, this project could lead to the development of sustained drug delivery systems that are more convenient, and more effective, for preventing and treating diseases than methods now available. ..
  66. Apical Chloride/Bicarbonate Exchangers in Small Intestine and Kidney
    Manoocher Soleimani; Fiscal Year: 2009
    ..abstract_text> ..
  67. BACTERIAL INDUCED COLITIS IN HLA-B27 RATS
    LEVINUS DIELEMAN; Fiscal Year: 2002
    ..This expertise will foster the development of an independent investigator with skills in both clinical and basic science. ..
  68. Fractional flow reserve measurement based on coronary angiographic images
    SABEE Y MOLLOI; Fiscal Year: 2010
    ..This quantification technique could be used to measure fractional flow reserve in patients undergoing standard coronary arteriography. ..
  69. COMPARISON OF RAT & TROUT HEPATIC P450 INDUCTION
    JOHN LECH; Fiscal Year: 1993
    The broad, long-term objective in this proposal is to gain insight into the mechanism by which phenobarbital and phenobarbital-type (e.g...
  70. REGULATION OF AUTOREACTIVE T CELLS IN IL10 KNOCKOUT MICE
    Peter Ernst; Fiscal Year: 1999
    ..Clarifying the role of these cytokines controlling auto-reactive T cells will define the pathogenesis of colitis and identify therapeutic strategies that can be applied to these intestinal diseases. ..
  71. BRAIN PHOSPHOINOSITIDES AND BARBITURATES
    DIWAKAR DESHMUKH; Fiscal Year: 1993
    ..of anesthetics and anticonvulsants is not yet clarified although the most useful of anticonvulsant drugs, phenobarbital, has been in use for 75 years...