pyrimethamine

Summary

Summary: One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.

Top Publications

  1. ncbi Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials
    John J Aponte
    Barcelona Centre for International Health Research, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Lancet 374:1533-42. 2009
  2. ncbi Intermittent preventive therapy for malaria during pregnancy using 2 vs 3 or more doses of sulfadoxine-pyrimethamine and risk of low birth weight in Africa: systematic review and meta-analysis
    Kassoum Kayentao
    Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    JAMA 309:594-604. 2013
  3. pmc Coverage of malaria protection in pregnant women in sub-Saharan Africa: a synthesis and analysis of national survey data
    Anna Maria van Eijk
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK
    Lancet Infect Dis 11:190-207. 2011
  4. ncbi Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi
    James G Kublin
    Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 187:1870-5. 2003
  5. ncbi Intercontinental spread of pyrimethamine-resistant malaria
    Cally Roper
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Science 305:1124. 2004
  6. pmc Options for the delivery of intermittent preventive treatment for malaria to children: a community randomised trial
    Margaret Kweku
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 4:e7256. 2009
  7. pmc Molecular markers of resistance to sulphadoxine-pyrimethamine one year after implementation of intermittent preventive treatment of malaria in infants in Mali
    Alassane Dicko
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, PO Box 1805 Bamako, Mali
    Malar J 9:9. 2010
  8. pmc Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Burkina Faso: a randomised, double-blind, placebo-controlled trial
    Amadou T Konate
    Centre National de Recherche et de Formation sur Paludisme, Ouagadougou, Burkina Faso
    PLoS Med 8:e1000408. 2011
  9. pmc Chloroquine resistance before and after its withdrawal in Kenya
    Leah Mwai
    Kenya Medical Research Institute Wellcome Trust Collaborative Research Programme, Kilifi, Kenya
    Malar J 8:106. 2009
  10. pmc High resistance of Plasmodium falciparum to sulphadoxine/pyrimethamine in northern Tanzania and the emergence of dhps resistance mutation at Codon 581
    Samwel Gesase
    National Institute for Medical Research, Tanga Centre, Tanga, Tanzania
    PLoS ONE 4:e4569. 2009

Detail Information

Publications323 found, 100 shown here

  1. ncbi Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials
    John J Aponte
    Barcelona Centre for International Health Research, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Lancet 374:1533-42. 2009
    Intermittent preventive treatment (IPT) is a promising strategy for malaria control in infants. We undertook a pooled analysis of the safety and efficacy of IPT in infants (IPTi) with sulfadoxine-pyrimethamine in Africa.
  2. ncbi Intermittent preventive therapy for malaria during pregnancy using 2 vs 3 or more doses of sulfadoxine-pyrimethamine and risk of low birth weight in Africa: systematic review and meta-analysis
    Kassoum Kayentao
    Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    JAMA 309:594-604. 2013
    Intermittent preventive therapy with sulfadoxine-pyrimethamine to control malaria during pregnancy is used in 37 countries in sub-Saharan Africa, and 31 of those countries use the standard 2-dose regimen...
  3. pmc Coverage of malaria protection in pregnant women in sub-Saharan Africa: a synthesis and analysis of national survey data
    Anna Maria van Eijk
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK
    Lancet Infect Dis 11:190-207. 2011
    Insecticide-treated nets and intermittent preventive treatment with sulfadoxine-pyrimethamine are recommended for the control of malaria during pregnancy in endemic areas in Africa, but there has been no analysis of coverage data at a ..
  4. ncbi Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi
    James G Kublin
    Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 187:1870-5. 2003
    In 1993, Malawi became the first African country to replace chloroquine with sulfadoxine-pyrimethamine nationwide in response to high rates of chloroquine-resistant falciparum malaria...
  5. ncbi Intercontinental spread of pyrimethamine-resistant malaria
    Cally Roper
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Science 305:1124. 2004
    Here we present molecular evidence demonstrating that malaria parasites bearing high-level pyrimethamine resistance originally arrived in Africa from southeast Asia...
  6. pmc Options for the delivery of intermittent preventive treatment for malaria to children: a community randomised trial
    Margaret Kweku
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 4:e7256. 2009
    ..We have evaluated the coverage of IPTc that can be achieved by two different delivery systems in Ghana...
  7. pmc Molecular markers of resistance to sulphadoxine-pyrimethamine one year after implementation of intermittent preventive treatment of malaria in infants in Mali
    Alassane Dicko
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, PO Box 1805 Bamako, Mali
    Malar J 9:9. 2010
    Intermittent preventive treatment in infants (IPTi) with sulphadoxine-pyrimethamine (SP) given during routine vaccinations is efficacious in preventing malaria disease and shows no interaction with the vaccines...
  8. pmc Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Burkina Faso: a randomised, double-blind, placebo-controlled trial
    Amadou T Konate
    Centre National de Recherche et de Formation sur Paludisme, Ouagadougou, Burkina Faso
    PLoS Med 8:e1000408. 2011
    ....
  9. pmc Chloroquine resistance before and after its withdrawal in Kenya
    Leah Mwai
    Kenya Medical Research Institute Wellcome Trust Collaborative Research Programme, Kilifi, Kenya
    Malar J 8:106. 2009
    ..Changes to those that occurred in the dihydrofolate reductase gene (dhfr) that confers resistance to the replacement drug, pyrimethamine/sulphadoxine were also compared.
  10. pmc High resistance of Plasmodium falciparum to sulphadoxine/pyrimethamine in northern Tanzania and the emergence of dhps resistance mutation at Codon 581
    Samwel Gesase
    National Institute for Medical Research, Tanga Centre, Tanga, Tanzania
    PLoS ONE 4:e4569. 2009
    Sulphadoxine-pyrimethamine (SP) a widely used treatment for uncomplicated malaria and recommended for intermittent preventive treatment of malaria in pregnancy, is being investigated for intermittent preventive treatment of malaria in ..
  11. pmc Impact of intermittent preventive treatment with sulphadoxine-pyrimethamine targeting the transmission season on the incidence of clinical malaria in children in Mali
    Alassane Dicko
    Malaria Research and Training Center, Departments of Epidemiology of Parasitic Diseases, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, P O Box 1805, Bamako, Mali
    Malar J 7:123. 2008
    ..However in most areas malaria morbidity and mortality remain high in older children...
  12. pmc A randomized placebo-controlled trial of intermittent preventive treatment in pregnant women in the context of insecticide treated nets delivered through the antenatal clinic
    Clara Menendez
    Barcelona Center for International Health Research CRESIB and Department of Pathology Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 3:e1934. 2008
    ..Current recommendations to prevent malaria in African pregnant women rely on insecticide treated nets (ITNs) and intermittent preventive treatment (IPTp). However, there is no information on the safety and efficacy of their combined use...
  13. pmc Drug coverage in treatment of malaria and the consequences for resistance evolution--evidence from the use of sulphadoxine/pyrimethamine
    Allen L Malisa
    Department of Biological Sciences, Faculty of Science, Sokoine University of Agriculture, SUA, PO Box 3038, Morogoro, Tanzania
    Malar J 9:190. 2010
    ..These models show that where the basis of resistance is multigenic, the effects of selection can be moderated by high recombination rates, which disrupt the associations between co-selected resistance genes...
  14. pmc Intermittent treatment to prevent pregnancy malaria does not confer benefit in an area of widespread drug resistance
    Whitney E Harrington
    Malaria Program, Seattle Biomedical Research Institute, Seattle, Washington, USA
    Clin Infect Dis 53:224-30. 2011
    Millions of African women receive sulfadoxine-pyrimethamine (SP) as intermittent preventive treatment during pregnancy (IPTp) to avoid poor outcomes that result from malaria...
  15. pmc Intermittent preventive treatment of malaria during pregnancy: a qualitative study of knowledge, attitudes and practices of district health managers, antenatal care staff and pregnant women in Korogwe District, North-Eastern Tanzania
    Godfrey Mubyazi
    National Institute for Medical Research, Ubwari Research Station, P O Box 81, Muheza, Tanzania
    Malar J 4:31. 2005
    ..This study assesses the knowledge, attitudes and practices of these groups in relation to malaria control with emphasis on IPTp services...
  16. ncbi Return of chloroquine antimalarial efficacy in Malawi
    Miriam K Laufer
    University of Maryland School of Medicine, Baltimore, MD 21201, USA
    N Engl J Med 355:1959-66. 2006
    ..1993, Malawi became the first country in Africa to replace chloroquine with the combination of sulfadoxine and pyrimethamine for the treatment of malaria. At that time, the clinical efficacy of chloroquine was less than 50%...
  17. pmc Competitive facilitation of drug-resistant Plasmodium falciparum malaria parasites in pregnant women who receive preventive treatment
    W E Harrington
    Seattle Biomedical Research Institute, 307 Westlake Avenue N, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 106:9027-32. 2009
    ..However, parasites resistant to the IPTp drug sulfadoxine-pyrimethamine (SP) have emerged worldwide, and infections with mixed resistant and susceptible parasites are exacerbated by ..
  18. ncbi Efficacy, safety, and selection of molecular markers of drug resistance by two ACTs in Mali
    Abdoulaye A Djimde
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto Stomatology, University of Bamako, Bamako, Mali
    Am J Trop Med Hyg 78:455-61. 2008
    ..the efficacy and safety of artesunate (AS) + amodiaquine (AQ, 3 days) versus AS (3 days) + sulfadoxine-pyrimethamine (SP, single dose) versus AS monotherapy (5 days) in Southern Mali...
  19. ncbi Reaching the Abuja target for intermittent preventive treatment of malaria in pregnancy in African women: a review of progress and operational challenges
    Jenny Hill
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK
    Trop Med Int Health 11:409-18. 2006
    ....
  20. ncbi Prevalence of molecular markers of Plasmodium falciparum resistance to sulfadoxine-pyrimethamine during the intermittent preventive treatment in infants coupled with the expanded program immunization in Senegal
    Babacar Faye
    Department of Parasitology, Faculty of de Medicine, Cheikh Anta Diop University of Dakar, Dakar, Senegal
    Parasitol Res 109:133-8. 2011
    Several studies have shown the efficacy of the intermittent preventive treatment (IPT) using sulfadoxine-pyrimethamine (SP) coupled with the expanded program of immunization (EPI) in infants...
  21. ncbi Effectiveness of intermittent preventive treatment with sulfadoxine-pyrimethamine during pregnancy on maternal and birth outcomes in Machinga district, Malawi
    Julie Gutman
    Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia 30322, USA
    J Infect Dis 208:907-16. 2013
    ..Despite increasing prevalence of malarial parasite resistance to sulfadoxine-pyrimethamine (SP), SP continues to be recommended for intermittent preventive treatment in pregnancy (IPTp).
  22. pmc Intermittent screening and treatment versus intermittent preventive treatment of malaria in pregnancy: a randomised controlled non-inferiority trial
    Harry Tagbor
    Department of Community Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
    PLoS ONE 5:e14425. 2010
    ..treatment of malaria in pregnancy (IPTp) may be compromised by the spread of resistance to sulphadoxine/pyrimethamine (SP) across Africa...
  23. pmc Drug resistance maps to guide intermittent preventive treatment of malaria in African infants
    Inbarani Naidoo
    London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    Parasitology 138:1469-79. 2011
    Intermittent preventive treatment of infants (IPTi) with sulphadoxine pyrimethamine (SP) is recommended as an additional malaria control intervention in high transmission areas of sub-Saharan Africa, provided its protective efficacy is ..
  24. pmc Stepwise acquisition of pyrimethamine resistance in the malaria parasite
    Elena R Lozovsky
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 106:12025-30. 2009
    The spread of high-level pyrimethamine resistance in Africa threatens to curtail the therapeutic lifetime of antifolate antimalarials...
  25. pmc The cost-effectiveness of intermittent preventive treatment for malaria in infants in Sub-Saharan Africa
    Lesong Conteh
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 5:e10313. 2010
    ..To date, there have been limited data on the cost-effectiveness of this strategy using sulfadoxine pyrimethamine (SP) and no published data on cost-effectiveness using other antimalarials.
  26. pmc Intermittent preventive treatment with sulphadoxine-pyrimethamine is effective in preventing maternal and placental malaria in Ibadan, south-western Nigeria
    Catherine O Falade
    Department of Clinical Pharmacology, University College Hospital, Ibadan, Nigeria
    Malar J 6:88. 2007
    Intermittent preventive treatment with sulphadoxine-pyrimethamine (IPT-SP) is currently the recommended regimen for prevention of malaria in pregnancy in endemic areas...
  27. pmc Effectiveness of antenatal clinics to deliver intermittent preventive treatment and insecticide treated nets for the control of malaria in pregnancy in Kenya
    Jenny Hill
    Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS ONE 8:e64913. 2013
    ..strategy for sub-Saharan Africa of intermittent-preventive-treatment (IPTp) with two doses of sulphadoxine-pyrimethamine (SP) and insecticide-treated-nets (ITNs) in pregnancy is low...
  28. pmc Prevalence of resistance associated polymorphisms in Plasmodium falciparum field isolates from southern Pakistan
    Najia Karim Ghanchi
    Malaria Research Lab, Infectious Diseases Unit, Department of Medicine, Karolinska University Hospital Karolinska Institutet, Retziusväg 10, Stockholm, Sweden
    Malar J 10:18. 2011
    ..The aim of this study was, therefore, to determine the prevalence of P. falciparum resistance associated polymorphisms in field isolates from southern Pakistan...
  29. pmc Temporal trends of sulphadoxine-pyrimethamine (SP) drug-resistance molecular markers in Plasmodium falciparum parasites from pregnant women in western Kenya
    Nnaemeka C Iriemenam
    Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA 30329 4018, USA
    Malar J 11:134. 2012
    Resistance to sulphadoxine-pyrimethamine (SP) in Plasmodium falciparum parasites is associated with mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes and has spread worldwide...
  30. pmc Evidence of selective sweeps in genes conferring resistance to chloroquine and pyrimethamine in Plasmodium falciparum isolates in India
    Tonya Mixson-Hayden
    Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, 4770 Buford Highway, MS F 12, Chamblee, GA 30341, USA
    Antimicrob Agents Chemother 54:997-1006. 2010
    ..to a lesser degree, in dhfr, indicating high levels of resistance to chloroquine and evolving resistance to pyrimethamine. Microsatellites surrounding pfcrt indicate that the resistant genotypes (SVMNT) were most similar to those ..
  31. pmc Antenatal receipt of sulfadoxine-pyrimethamine does not exacerbate pregnancy-associated malaria despite the expansion of drug-resistant Plasmodium falciparum: clinical outcomes from the QuEERPAM study
    Steve M Taylor
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, 27599, USA
    Clin Infect Dis 55:42-50. 2012
    Antenatal intermittent preventive therapy with 2 doses of sulfadoxine-pyrimethamine (IPTp-SP) is the mainstay of efforts in sub-Saharan Africa to prevent pregnancy-associated malaria (PAM)...
  32. pmc In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa
    Christin Sisowath
    Infectious Diseases Unit, Department of Medicine and Karolinska Institutet, Stockholm, Sweden
    J Infect Dis 199:750-7. 2009
    ..Identification of drug-specific parasite determinants that contribute to treatment failures will provide important tools for the detection and surveillance of AL resistance...
  33. pmc Pharmacokinetic properties of sulfadoxine-pyrimethamine in pregnant women
    Harin A Karunajeewa
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Antimicrob Agents Chemother 53:4368-76. 2009
    To determine the pharmacokinetic disposition of sulfadoxine (SDOX) and pyrimethamine (PYR) when administered as intermittent presumptive treatment during pregnancy (IPTp) for malaria, 30 Papua New Guinean women in the second or third ..
  34. ncbi A trial of combination antimalarial therapies in children from Papua New Guinea
    Harin A Karunajeewa
    School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia
    N Engl J Med 359:2545-57. 2008
    ..Malaria control is difficult where there is intense year-round transmission of multiple plasmodium species, such as in Papua New Guinea...
  35. pmc Two strategies for the delivery of IPTc in an area of seasonal malaria transmission in the Gambia: a randomised controlled trial
    Kalifa A Bojang
    Medical Research Council Laboratories, Banjul, The Gambia
    PLoS Med 8:e1000409. 2011
    ..In rural areas, RCH trekking teams provide most of the health care to children under the age of 5 years in the Infant Welfare Clinic, and provide antenatal care for pregnant women...
  36. pmc Cost effectiveness of seasonal intermittent preventive treatment using amodiaquine & artesunate or sulphadoxine-pyrimethamine in Ghanaian children
    Lesong Conteh
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 5:e12223. 2010
    ..It is important to determine the costs associated with IPTc delivery via community based volunteers and also the potential savings to health care providers and caretakers due to malaria episodes averted as a consequence of IPTc...
  37. ncbi A selective sweep driven by pyrimethamine treatment in southeast asian malaria parasites
    Shalini Nair
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Mol Biol Evol 20:1526-36. 2003
    ..falciparum. Point mutations in dhfr are known to be responsible for resistance to the antimalarial drug pyrimethamine, and resistance to this drug has spread rapidly in Southeast (SE) Asia after its introduction in 1970s...
  38. pmc Plasmodium falciparum gametocyte carriage in asymptomatic children in western Kenya
    J Teun Bousema
    Department of Medical Microbiology, University Medical Centre, Nijmegen, The Netherlands
    Malar J 3:18. 2004
    ..This study identified factors that influence gametocytaemia in asymptomatic children in the absence and presence of pyrimethamine-sulphadoxine (SP) antimalarial treatment.
  39. pmc Knowledge of malaria influences the use of insecticide treated nets but not intermittent presumptive treatment by pregnant women in Tanzania
    Rhoida Y Nganda
    Kilimanjaro Christian Medical Centre, PO Box 3010, Moshi, Tanzania
    Malar J 3:42. 2004
    ..has recently adopted a policy of intermittent presumptive treatment for pregnant women using sulphadoxine-pyrimethamine (IPTp-SP)...
  40. ncbi Pharmacokinetics of sulfadoxine and pyrimethamine in intermittent preventive treatment of malaria in pregnancy
    M M Nyunt
    Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Clin Pharmacol Ther 87:226-34. 2010
    ..In order to minimize the burden, sulfadoxine-pyrimethamine (SP) is widely used in Africa as an intermittent preventive treatment of malaria in pregnancy (IPTp)...
  41. ncbi Use of antenatal care services and intermittent preventive treatment for malaria among pregnant women in Blantyre District, Malawi
    Timothy H Holtz
    Malaria Epidemiology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Trop Med Int Health 9:77-82. 2004
    ..We performed a cluster sample survey to study the use of sulfadoxine-pyrimethamine (SP) for IPT among recently pregnant women in February 2000 in Blantyre District, Malawi...
  42. ncbi (Sub)microscopic Plasmodium falciparum gametocytaemia in Kenyan children after treatment with sulphadoxine-pyrimethamine monotherapy or in combination with artesunate
    Petra Schneider
    Radboud University Nijmegen Medical Centre, Medical Microbiology 268, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Int J Parasitol 36:403-8. 2006
    ..falciparum malaria after treatment with sulphadoxine-pyrimethamine (SP) or a combination of SP and artesunate (SP+AS), in a 28-days drug efficacy study...
  43. pmc A trial of the efficacy, safety and impact on drug resistance of four drug regimens for seasonal intermittent preventive treatment for malaria in Senegalese children
    Cheikh Sokhna
    Institut de Recherche pour le Developpement, Dakar, Senegal
    PLoS ONE 3:e1471. 2008
    ..A trial of seasonal intermittent preventive treatment (IPT) with sulfadoxine-pyrimethamine (SP) and a single dose of artesunate (AS) showed an 86% reduction in the incidence of malaria in Senegal but ..
  44. pmc Association of genetic mutations in Plasmodium vivax dhfr with resistance to sulfadoxine-pyrimethamine: geographical and clinical correlates
    M Imwong
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 45:3122-7. 2001
    ..0001). The dhfr PCR products of P. vivax from 32 Thai patients treated with the antifolate sulfadoxine-pyrimethamine (S-P) were investigated. All samples showed either double (53%) or triple (47%) mutations...
  45. pmc Validity of self-reported use of sulphadoxine-pyrimethamine intermittent presumptive treatment during pregnancy (IPTp): a cross-sectional study
    Fatuma Namusoke
    Department of Biochemistry, Makerere University, Kampala, Uganda
    Malar J 11:310. 2012
    ..The WHO recommends use of sulphadoxine-pyrimethamine (SP) for intermittent preventive treatment of malaria during pregnancy (IPTp) in endemic areas...
  46. ncbi Following the path of most resistance: dhps K540E dispersal in African Plasmodium falciparum
    Inbarani Naidoo
    London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    Trends Parasitol 26:447-56. 2010
    ..By contrast, resistance to sulphadoxine-pyrimethamine (SPR) has emerged during an era of molecular surveillance, and the changing prevalence of SPR conferred by ..
  47. pmc Selection of pfdhfr/pfdhps alleles and declining artesunate/sulphadoxine-pyrimethamine efficacy against Plasmodium falciparum eight years after deployment in eastern Sudan
    Nahla B Gadalla
    Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 12:255. 2013
    Artesunate/sulphadoxine-pyrimethamine (AS/SP) has been the first-line treatment for falciparum malaria in Sudan since 2004. The impact of this combination on anti-malarial resistance-associated molecular markers has not been investigated...
  48. ncbi Efficacy of intermittent preventive treatment with sulfadoxine-pyrimethamine on placental parasitemia in pregnant women in midwestern Nigeria
    Michael E Aziken
    Department of Obstetrics and Gynecology, University of Benin Teaching Hospital, Benin City, Edo State, Nigeria
    Int J Gynaecol Obstet 112:30-3. 2011
    To assess the effect of intermittent preventive treatment with sulfadoxine and pyrimethamine (IPT-SP) on placental parasitemia and maternal and perinatal outcome.
  49. ncbi Intermittent treatment for the prevention of malaria during pregnancy in Benin: a randomized, open-label equivalence trial comparing sulfadoxine-pyrimethamine with mefloquine
    Valérie Briand
    Institut de Recherche pour le Developpement, santé de la mère et de l enfant en milieu tropical, Faculte de Pharmacie, 4 avenue de l Observatoire, Paris Cedex 06, France
    J Infect Dis 200:991-1001. 2009
    In the context of the increasing resistance to sulfadoxine-pyrimethamine (SP), we evaluated the efficacy of mefloquine (MQ) for intermittent preventive treatment during pregnancy (IPTp).
  50. pmc Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi
    David J Bell
    Tropical and Infectious Diseases Unit, Royal Liverpool University Hospital, Liverpool L7 8XP, UK
    Malar J 8:204. 2009
    Sulphadoxine-pyrimethamine (SP) is the only single dose therapy for uncomplicated malaria, but there is widespread resistance...
  51. pmc Placental malaria among HIV-infected and uninfected women receiving anti-folates in a high transmission area of Uganda
    Patrick M Newman
    School of Medicine, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94131, USA
    Malar J 8:254. 2009
    ..daily trimethoprim-sulphamethoxazole (TS) and HIV-uninfected women to receive intermittent sulphadoxine-pyrimethamine (SP)...
  52. ncbi No rebound of morbidity following intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in Gabon
    Martin P Grobusch
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
    J Infect Dis 200:1658-61. 2009
    In the context of a trial studying intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in Lambaréné, Gabon, children aged 18-30 months were followed up after having received their last dose at an age of 15 ..
  53. ncbi Therapeutic efficacy of chloroquine in Plasmodium vivax from areas with different epidemiological patterns in India and their Pvdhfr gene mutation pattern
    Neena Valecha
    Malaria Research Centre ICMR, 22 Sham Nath Marg, Delhi 110 054, India
    Trans R Soc Trop Med Hyg 100:831-7. 2006
    ..Although P. vivax has been reported to be inherently resistant to sulfonamide and pyrimethamine, Indian isolates exhibited only double mutations in dhfr in vitro.
  54. pmc Hitchhiking and selective sweeps of Plasmodium falciparum sulfadoxine and pyrimethamine resistance alleles in a population from central Africa
    Andrea M McCollum
    Program in Population Biology, Ecology, and Evolution, Emory University, Atlanta, Georgia, USA
    Antimicrob Agents Chemother 52:4089-97. 2008
    Sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum is encoded by a number of mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhps) genes...
  55. ncbi Antifolates can have a role in the treatment of Plasmodium vivax
    Vivian N Hawkins
    Department of Genome Sciences, University of Washington, Box 355065, Seattle, WA 98195, USA
    Trends Parasitol 23:213-22. 2007
    ..vivax is a serious health concern in many regions and is sometimes inadvertently treated with sulfadoxine-pyrimethamine (SP)...
  56. pmc Seasonal intermittent preventive treatment for the prevention of anaemia and malaria in Ghanaian children: a randomized, placebo controlled trial
    Margaret Kweku
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 3:e4000. 2008
    ..We have investigated the effect of intermittent preventive treatment with sulphadoxine-pyrimethamine or artesunate plus amodiaquine on anaemia and malaria in children in an area of intense, prolonged, seasonal ..
  57. ncbi Randomized trial of 2-dose versus monthly sulfadoxine-pyrimethamine intermittent preventive treatment for malaria in HIV-positive and HIV-negative pregnant women in Malawi
    Scott J Filler
    Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 194:286-93. 2006
    Intermittent preventive treatment during pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) decreases placental malaria parasitemia and associated maternal anemia, premature delivery, and low birth weight...
  58. pmc Determinants of use of intermittent preventive treatment of malaria in pregnancy: Jinja, Uganda
    Laura R Sangaré
    Department of Global Health, University of Washington, Seattle, Washington, USA
    PLoS ONE 5:e15066. 2010
    ..means of preventing malaria during pregnancy is intermittent preventive therapy (IPTp) with sulfadoxine/pyrimethamine (SP)...
  59. pmc Selection strength and hitchhiking around two anti-malarial resistance genes
    Denae Nash
    Southwest Foundation for Biomedical Research SFBR, San Antonio, TX 78245, USA
    Proc Biol Sci 272:1153-61. 2005
    ..mutation in pfcrt conferring resistance to chloroquine (CQ) and 2-4 mutations in dhfr conferring resistance to pyrimethamine. By contrast, we found both wild-type and resistant alleles at both genes in Laos...
  60. ncbi The effect of health care worker training on the use of intermittent preventive treatment for malaria in pregnancy in rural western Kenya
    P O Ouma
    Kenya Medical Research Institute, Centre for Vector Biology and Control Research, Kisumu, Kenya
    Trop Med Int Health 12:953-61. 2007
    In 1998, Kenya adopted intermittent preventive treatment (IPTp) with sulphadoxine-pyrimethamine (SP) for malaria prevention during pregnancy...
  61. pmc Individual, facility and policy level influences on national coverage estimates for intermittent preventive treatment of malaria in pregnancy in Tanzania
    Tanya Marchant
    Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 7:260. 2008
    ..This investigation measured coverage of IPTp at national level in Tanzania and examined the role of individual, facility, and policy level influences on achieved coverage...
  62. pmc Therapeutic response of multidrug-resistant Plasmodium falciparum and P. vivax to chloroquine and sulfadoxine-pyrimethamine in southern Papua, Indonesia
    A Ratcliff
    International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia
    Trans R Soc Trop Med Hyg 101:351-9. 2007
    ..resistance in southern Papua, Indonesia, we assessed the therapeutic efficacy of chloroquine plus sulfadoxine-pyrimethamine (CQ+SP) for Plasmodium falciparum infections as well as CQ monotherapy for P. vivax infections...
  63. pmc Plasmodium falciparum isolates in India exhibit a progressive increase in mutations associated with sulfadoxine-pyrimethamine resistance
    Anwar Ahmed
    Department of Biotechnology, All India Institute of Medical Sciences, New Delhi 110029 Malaria Research Centre, 22 Sham Nath Marg, New Delhi 110054, India
    Antimicrob Agents Chemother 48:879-89. 2004
    The combination of sulfadoxine-pyrimethamine (SP) is used as a second line of therapy for the treatment of uncomplicated chloroquine-resistant Plasmodium falciparum malaria...
  64. pmc Duration of protection against clinical malaria provided by three regimens of intermittent preventive treatment in Tanzanian infants
    Matthew Cairns
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 5:e9467. 2010
    ..Understanding the mechanism is essential for development of replacements for sulfadoxine-pyrimethamine (SP) where it is no longer effective...
  65. pmc Cost-effectiveness of malaria intermittent preventive treatment in infants (IPTi) in Mozambique and the United Republic of Tanzania
    Guy Hutton
    Swiss Tropical Institute, Basel, Switzerland
    Bull World Health Organ 87:123-9. 2009
    To estimate the cost-effectiveness of malaria intermittent preventive treatment in infants (IPTi) using sulfadoxine-pyrimethamine (SP).
  66. pmc In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation
    Steven M Kiara
    Kenya Medical Research Institute KEMRI Wellcome Trust Collaborative Research Program, P O Box 230, 80108 Kilifi, Kenya
    Antimicrob Agents Chemother 53:3793-8. 2009
    We have analyzed the activities of the antifolates pyrimethamine (PM), chlorcycloguanil (CCG), WR99210, trimethoprim (TMP), methotrexate (MTX), and trimetrexate (TMX) against Kenyan Plasmodium falciparum isolates adapted in vitro for ..
  67. ncbi Two-dose versus monthly intermittent preventive treatment of malaria with sulfadoxine-pyrimethamine in HIV-seropositive pregnant Zambian women
    Davidson H Hamer
    Center for International Health and Development, Boston University School of Public Health, Boston, MA 02118, USA
    J Infect Dis 196:1585-94. 2007
    ..However, the optimal dosing regimen in settings in which human immunodeficiency virus (HIV) is highly prevalent among pregnant women remains controversial...
  68. pmc Access and barriers to measures targeted to prevent malaria in pregnancy in rural Kenya
    Priscilla W Gikandi
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Research Programme, Nairobi, Kenya
    Trop Med Int Health 13:208-17. 2008
    ..pregnant women from using insecticide-treated nets (ITN) and intermittent presumptive treatment (IPT) with sulphadoxine-pyrimethamine (SP) 5 years after the launch of the national malaria strategy promoting these measures in Kenya.
  69. ncbi Ethnographic study of factors influencing compliance to intermittent preventive treatment of malaria during pregnancy among Yao women in rural Malawi
    Annika Launiala
    School of Public Health, FIN 33014 University of Tampere, Tampere, Finland
    Trans R Soc Trop Med Hyg 101:980-9. 2007
    ..This study discovered several factors affecting IPT. These were: unclear messages about IPT with sulfadoxine-pyrimethamine (SP) from nurses; timing of SP-1; periodic shortages of SP; women's limited understanding of IPT-SP; tendency ..
  70. pmc Randomized trial of piperaquine with sulfadoxine-pyrimethamine or dihydroartemisinin for malaria intermittent preventive treatment in children
    Badara Cisse
    Department of Parasitology and Mycology, Universite Cheikh Anta Diop, Dakar, Senegal
    PLoS ONE 4:e7164. 2009
    ..trial to determine whether piperaquine in combination with either dihydroartemisin (DHA) or sulfadoxine-pyrimethamine (SP) is as effective, and better tolerated, than SP plus amodiaquine (AQ), when used for intermittent ..
  71. pmc Efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria: revisiting molecular markers in an area of emerging AQ and SP resistance in Mali
    Mamadou Tekete
    Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Malaria Research and Training Center, Bamako, Mali
    Malar J 8:34. 2009
    To update the National Malaria Control Programme of Mali on the efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria.
  72. ncbi Selection of antifolate-resistant Plasmodium falciparum by sulfadoxine-pyrimethamine treatment and infectivity to Anopheles mosquitoes
    Fabian Mendez
    Escuela de Salud Publica, Universidad del Valle, Cali, Colombia
    Am J Trop Med Hyg 77:438-43. 2007
    ..DHFR) and dihydropteroate synthase (DHPS) in Plasmodium falciparum are selected by treatment with sulfadoxine pyrimethamine (SP)...
  73. ncbi Parasitological and clinical efficacy of standard treatment regimens against Plasmodium falciparum, P. vivax and P. malariae in Papua New Guinea
    Blaise Genton
    Swiss Tropical Institute, Basel, Switzerland
    P N G Med J 48:141-50. 2005
    ..treatment failure (TF) and parasite resistance to amodiaquine (AQ), chloroquine (CQ) and quinine+sulfadoxine/pyrimethamine (Q+SP) for malaria in a rural health centre of the East Sepik Province...
  74. ncbi Intermittent preventive treatment of malaria in pregnancy: at the crossroads of public health policy
    R Matthew Chico
    Department of Disease Control, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 16:774-85. 2011
    The intermittent preventive treatment of malaria in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) has been a key component of the focused antenatal care package for nearly a decade, reducing the burden of low birthweight ..
  75. ncbi The efficacy of sulfadoxine-pyrimethamine alone and in combination with chloroquine for malaria treatment in rural Eastern Sudan: the interrelation between resistance, age and gametocytogenesis
    Ishraga E A-Elbasit
    Malaria Research Centre, Department of Biochemistry, University of Khartoum, Khartoum, Sudan
    Trop Med Int Health 11:604-12. 2006
    ..To compare the efficacy of sulfadoxine-pyremethamine (SP)+chloroquine (CQ) combination treatment against falciparum malaria with SP treatment alone...
  76. pmc The evolution of pyrimethamine resistant dhfr in Plasmodium falciparum of south-eastern Tanzania: comparing selection under SP alone vs SP+artesunate combination
    Allen L Malisa
    Sokoine University of Agriculture, Department of Biological Sciences, Faculty of Science, Box 3038, Morogoro, Tanzania
    Malar J 10:317. 2011
    Sulphadoxine-pyrimethamine (SP) resistance is now widespread throughout east and southern Africa and artemisinin compounds in combination with synthetic drugs (ACT) are recommended as replacement treatments by the World Health ..
  77. ncbi Intermittent preventive treatment of malaria in pregnancy (IPTp): do frequent antenatal care visits ensure access and compliance to IPTp in Ugandan rural communities?
    Richard Ndyomugyenyi
    Malaria Control Programme, Ministry of Health, P O Box 7272, Kampala, Uganda
    Trans R Soc Trop Med Hyg 104:536-40. 2010
    ..ANC) visits and coverage of intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP), and barriers to IPTp-SP access were examined...
  78. pmc In vitro susceptibility of various genotypic strains of Toxoplasma gondii to pyrimethamine, sulfadiazine, and atovaquone
    Pascale Meneceur
    Laboratory of Parasitology EA 3520, University Denis Diderot, 15 rue de l Ecole de Medecine, 75250 Paris Cedex 06, France
    Antimicrob Agents Chemother 52:1269-77. 2008
    Sulfadiazine, pyrimethamine, and atovaquone are widely used for the treatment of severe toxoplasmosis. Their in vitro activities have been almost exclusively demonstrated on laboratory strains belonging to genotype I...
  79. pmc Rural Gambian women's reliance on health workers to deliver sulphadoxine-pyrimethamine as recommended intermittent preventive treatment for malaria in pregnancy
    Loretta Brabin
    Academic Unit of Obstetrics and Gynaecology, University of Manchester, Manchester M13 OJH, UK
    Malar J 8:25. 2009
    The use of most anti-malarial medications is restricted during pregnancy, but two doses of sulphadoxine-pyrimethamine are recommended after the first trimester as intermittent preventive treatment in pregnancy (IPTp)...
  80. ncbi HIV and placental infection modulate the appearance of drug-resistant Plasmodium falciparum in pregnant women who receive intermittent preventive treatment
    Clara Menendez
    Barcelona Centre for International Health Research, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Clin Infect Dis 52:41-8. 2011
    Factors involved in the development of resistance to sulphadoxine-pyrimethamine (SP) by Plasmodium falciparum, particularly in the context of intermittent preventive treatment during pregnancy (IPTp), are not well known...
  81. ncbi High prevalence of the 437G mutation associated with sulfadoxine resistance among Plasmodium falciparum clinical isolates from Iran, three years after the introduction of sulfadoxine-pyrimethamine
    Sedigheh Zakeri
    Malaria and Vector Research Group, Biotechnology Research Center, Pasteur Institute of Iran, Pasteur Avenue, Tehran, Iran
    Int J Infect Dis 14:e123-8. 2010
    ..was to determine the frequency of dhfr and dhps resistance-associated haplotypes in Plasmodium falciparum isolates, three years after the introduction of sulfadoxine-pyrimethamine (SP) as the first-line antimalarial treatment in Iran.
  82. pmc Malaria prevention with IPTp during pregnancy reduces neonatal mortality
    Clara Menendez
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 5:e9438. 2010
    ..Malaria in pregnancy may affect neonatal survival, though no strong evidence exists to support this association...
  83. pmc Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 7:249. 2008
    ..The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity...
  84. pmc Patterns of case management and chemoprevention for malaria-in-pregnancy by public and private sector health providers in Enugu state, Nigeria
    Ogochukwu C Onwujekwe
    Department of Pharmacy, University of Nigeria Teaching Hospital, Ituku Ozalla, Enugu State, Nigeria
    BMC Res Notes 5:211. 2012
    ..Information is required on how to improve its prevention and treatment from both the providers' and consumers' perspectives...
  85. ncbi Prospective randomized trial of trimethoprim/sulfamethoxazole versus pyrimethamine and sulfadiazine in the treatment of ocular toxoplasmosis
    Masoud Soheilian
    Ocular Inflammatory and Uveitis Service, Department of Ophthalmology, and Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Ophthalmology 112:1876-82. 2005
    To compare the efficacy of the classic treatment of ocular toxoplasmosis (pyrimethamine, sulfadiazine, and prednisolone) with a regimen consisting of trimethoprim/sulfamethoxazole (co-trimoxazole) plus prednisolone.
  86. ncbi Plasmodium vivax: prevalence of mutations associated with sulfadoxine-pyrimethamine resistance in Plasmodium vivax clinical isolates from Pakistan
    Sedigheh Zakeri
    Malaria and Vector Research Group, Biotechnology Research Center, Pasteur Institute of Iran, Pasteur Avenue, PO BOX 1316943551, Tehran, Iran
    Exp Parasitol 127:167-72. 2011
    ..study was to investigate the frequency of SNPs-haplotypes of dhfr and dhps genes associated to sulfadoxine-pyrimethamine (SP) resistance in Plasmodium vivax clinical isolates circulating in a malaria endemic area, Pakistan...
  87. ncbi Frequency distribution of antimalarial drug-resistant alleles among isolates of Plasmodium falciparum in Bangui, Central African Republic
    Didier Menard
    Pasteur Institute of Bangui, Bangui, Central African Republic
    Am J Trop Med Hyg 74:205-10. 2006
    ..frequency distribution of mutant alleles of genes associated with resistance to chloroquine and sulfadoxine-pyrimethamine in Plasmodium falciparum isolates in Bangui, Central African Republic. Mutant alleles of the P...
  88. pmc Use of antenatal care, maternity services, intermittent presumptive treatment and insecticide treated bed nets by pregnant women in Luwero district, Uganda
    Mpungu S Kiwuwa
    Clinical Epidemiology Unit, Faculty of Medicine, Makerere University, Uganda
    Malar J 7:44. 2008
    ..of insecticide-treated nets (ITNs) and introduction of intermittent preventive treatment with sulphadoxine-pyrimethamine for pregnant women (IPTp-SP) as a national policy in 2000...
  89. pmc Markers of sulfadoxine-pyrimethamine-resistant Plasmodium falciparum in placenta and circulation of pregnant women
    Frank P Mockenhaupt
    Institute of Tropical Medicine and International Health, Spandauer Damm 130, 14050 Berlin, Germany
    Antimicrob Agents Chemother 51:332-4. 2007
    ..of Plasmodium falciparum in pregnancy may impair the usefulness of molecular markers of sulfadoxine-pyrimethamine resistance...
  90. pmc Differences in selective pressure on dhps and dhfr drug resistant mutations in western Kenya
    Andrea M McCollum
    Program in Population Biology, Ecology, and Evolution, Emory University, Atlanta, GA, USA
    Malar J 11:77. 2012
    ..This study describes the dynamics of strong selection for mutations conferring resistance against sulphadoxine-pyrimethamine (SP), a combination therapy, in western Kenya between 1992 and 1999, just before SP became first-line therapy (..
  91. pmc Bottlenecks for high coverage of intermittent preventive treatment in pregnancy: the case of adolescent pregnancies in rural Burkina Faso
    Koen Peeters Grietens
    Prince Leopold Institute for Tropical Medicine, Antwerp, Belgium
    PLoS ONE 5:e12013. 2010
    ....
  92. ncbi Randomized trial of intravitreal clindamycin and dexamethasone versus pyrimethamine, sulfadiazine, and prednisolone in treatment of ocular toxoplasmosis
    Masoud Soheilian
    Department of Ophthalmology and Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti Medical University, Tehran, Iran
    Ophthalmology 118:134-41. 2011
    ..To compare the efficacy of intravitreal injection of clindamycin and dexamethasone with classic treatment for ocular toxoplasmosis...
  93. pmc Field evaluation of the intermittent preventive treatment of malaria during pregnancy (IPTp) in Benin: evolution of the coverage rate since its implementation
    Tania C D A d'Almeida
    Faculté des Sciences de Santé, Cotonou, Benin
    Parasit Vectors 4:108. 2011
    ..of compliance problems and drug resistance, was replaced by intermittent preventive treatment with sulfadoxine-pyrimethamine (ITPp-SP) with two single doses taken after 16 weeks of amenorrhea, at least 4 weeks apart...
  94. pmc The fitness of drug-resistant malaria parasites in a rodent model: multiplicity of infection
    S Huijben
    Department of Biology, Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA 16802, USA
    J Evol Biol 24:2410-22. 2011
    ..This would greatly simplify the computational problems of adequately capturing within-host ecology in models of drug resistance evolution in malaria...
  95. ncbi Mother-to-child transmission of HIV-1: association with malaria prevention, anaemia and placental malaria
    D Naniche
    Barcelona Center for International Health Research CRESIB, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    HIV Med 9:757-64. 2008
    ..Prevention of malaria in pregnancy could thus potentially affect MTCT of HIV. We studied the impact of intermittent preventive treatment during pregnancy (IPTp) on HIV-1 MTCT in southern Mozambique...
  96. pmc Primaquine clears submicroscopic Plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunate
    Seif Shekalaghe
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 2:e1023. 2007
    P. falciparum gametocytes may persist after treatment with sulphadoxine-pyrimethamine (SP) plus artesunate (AS) and contribute considerably to malaria transmission...
  97. ncbi A shared Asian origin of the triple-mutant dhfr allele in Plasmodium falciparum from sites across Africa
    Oumou Maïga
    Universite Paris Descartes, Paris, France
    J Infect Dis 196:165-72. 2007
    Usefulness of sulfadoxine-pyrimethamine as first-line therapy for uncomplicated Plasmodium falciparum malaria and intermittent preventive treatment in pregnancy throughout sub-Saharan Africa is compromised by the spread of dhfr alleles ..
  98. pmc Placental malaria and low birth weight in pregnant women living in a rural area of Burkina Faso following the use of three preventive treatment regimens
    Alfred B Tiono
    Centre National de Recherche et de Formation sur le Paludisme, Ministere de la Sante, Ouagadougou, Burkina Faso
    Malar J 8:224. 2009
    ..It compares the efficacy of two IPT regimens, using chloroquine (CQ) or sulphadoxine/pyrimethamine (SP), with the classical chemoprophylaxis regimen using CQ in reducing the adverse outcomes of malaria ..
  99. pmc Novel point mutations in the dihydrofolate reductase gene of Plasmodium vivax: evidence for sequential selection by drug pressure
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, National Science and Technology Development Agency, Bangkok, Thailand
    Antimicrob Agents Chemother 47:1514-21. 2003
    ..Highly mutated genes carry the S-->T rather than the S-->N mutation at residue 117. Mutations at residues 57 and 61 then occur, followed by a fifth mutation at residue 13...
  100. pmc A trial of intermittent preventive treatment and home-based management of malaria in a rural area of The Gambia
    Sanie Sesay
    Medical Research Council Laboratories, Banjul, The Gambia
    Malar J 10:2. 2011
    ..The potential benefits of combining IPT in children (IPTc) with home management of malaria (HMM) was investigated...
  101. pmc Randomized controlled trial of fosmidomycin-clindamycin versus sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria
    Sunny Oyakhirome
    Institute for Tropical Medicine, Department for Parasitology, University of Tubingen, Wilhelmstrasse 27, Tubingen, Germany
    Antimicrob Agents Chemother 51:1869-71. 2007
    ..therapy given every 12 h for 3 days was compared with a standard single oral dose of sulfadoxine-pyrimethamine. The two treatments showed comparably good tolerabilities and had an identical high degree of efficacy of 94% ..

Research Grants61

  1. TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2003
    ..TS shares its mechanism of action with pyrimethamine-sulfadoxine (PS) and other antifolate drugs used to treat malaria, which is responsible for an estimated 2...
  2. Molecular epidemiology of drug resistance and population genetic structure of Pla
    Fangli Lu; Fiscal Year: 2013
    ..Sulfadoxine-pyrimethamine (SP) targets the dhfr and dhps genes of P...
  3. Development of a Chloroquine Replacement Drug
    MICHAEL KEVIN RISCOE; Fiscal Year: 2010
    ..to multiple drugs including: the quinolines - chloroquine, quinine, and mefloquine;the antifolates - pyrimethamine and sulfadoxine;and the anti-respiratory combination of atovaquone and proguanil...
  4. Institutional Collaboration between LSTM and CDC and Prevention on Malaria(U01)
    FEIKO OLAF TER KUILE; Fiscal Year: 2013
    ..central coordination of a multi-country observational study in Africa to determine the effect of sulfadoxine-pyrimethamine (SP) resistance on intermittent preventive treatment in pregnancy (IPTp) effectiveness, and two studies in ..
  5. Optimization of pyrimidinyl prodrugs (PYPs) for malaria chemotherapy
    PRADIPSINH RATHOD; Fiscal Year: 2009
    ..quantitative in vitro studies of safety versus potency suggest that PYP1, as is, has comparable selectivity to pyrimethamine. It can be even better with some improved pharmacokinetics and controlled drug release...
  6. Inflammation, Anemia and Respiratory Distress in Mothers and Infants with Malaria
    WHITNEY ELIZABETH HARRINGTON; Fiscal Year: 2011
    ..pregnant women in Africa receive intermittent presumptive treatment (IPTp) with the antimalarial sulfadoxine-pyrimethamine (SP) each year to prevent P...
  7. PfSPZ Challenge with Chemoprophylaxis: Phase 1 Trial to Assess Liver Stage Drug
    STEPHEN LEV HOFFMAN; Fiscal Year: 2013
    ..1) the pilot trial phase will determine the optimal timing after PfSPZ inoculation to administer the drug pyrimethamine that is approved by FDA for prophylaxis and treatment of susceptible P...
  8. Research Activities in Support of Malaria Prevention and Control in Uganda (PMI)
    MOSES ROBERT KAMYA; Fiscal Year: 2013
    ..2) We will perform a clinical trial to measure the in vivo efficacy of sulfadoxine-pyrimethamine (SP) for the clearance of asymptomatic parasitemia in pregnant women as a means of evaluating the ..
  9. Genome Surveillance for drug resistant malaria
    Dyann F Wirth; Fiscal Year: 2010
    ..the great utility of smaller scale studies by others that identified the genes responsible for chloroquine and pyrimethamine resistance...
  10. CRYPTOSPORIDIUM DHFR AS A CHEMOTHERAPEUTIC TARGET
    Richard Nelson; Fiscal Year: 1992
    ..However, DHFR also varies greatly among protozoa and the available inhibitors (pyrimethamine, trimethoprim, proguanil) bind poorly to some protozoan DHFRs (Leishmania, Trypanosoma, and Eimeria) and very ..
  11. IMPACT OF TS PROPHYLAXIS ON ANTIFOLATE RESISTANT MALARIA
    James Kublin; Fiscal Year: 2000
    ..TS shares its mechanism of action with pyrimethamine-sulfadoxine (PS) and other antifolate drugs used to treat malaria...
  12. LIPOPHILIC ANTIFOLATES AND AIDS OPPORTUNISTIC INFECTIONS
    Andre Rosowsky; Fiscal Year: 2004
    ..high potency of trimetrexate (TMQ) and piritrexim (PTX) with the species selectivity of trimethoprim (TMP) and pyrimethamine (PM) against Pc, Tg, or Cp dihydrofolate reductase (DHFR) versus rodent or human DHFR...
  13. Preventing Pregnancy Malaria: Maternal-Infant Outcomes
    Michal Fried; Fiscal Year: 2009
    ..In the studies proposed here, three new IPTp regimens (chlorproguanil-dapsone (LapDap);mefloquine;sulfadoxine-pyrimethamine (SP) + azithromycin) will be compared to the currently recommended regimen (SP alone) for their efficacy and ..
  14. SP resistance markers & falciparum malaria transmission
    Fabian Mendez; Fiscal Year: 2004
    ..However, resistance to the combination antifolate drug sulfadoxine-pyrimethamine (SP) has remained low in Colombia in contrast to high rates of SP failure elsewhere in the region...
  15. A Phase l Study of Pyrimethamine in patients with GM-2 Gangliosidosis
    Bijan Almassian; Fiscal Year: 2007
    ..unreadable] [unreadable] In 2006, ExSAR applied for orphan drug designation from the FDA for pyrimethamine for the treatment of patients affected with late-onset GM2-gangliosidosis...
  16. Synthesis and Evaluation of Novel Antimalarial Agents
    Shuren Zhu; Fiscal Year: 2005
    ..falciparum malaria parasite clones: W2 (susceptible to mefloquine but resistant to chloroquine, sulfadoxine, pyrimethamine, and quinine) and D6 (resistant to mefloquine but susceptible to chloroquine, sulfadoxine, pyrimethamine and ..
  17. Molecular epidemiology of sulfadoxine-pyrimethamine
    Thomas Egwang; Fiscal Year: 2006
    ..The government interim drug policy recommends the use of the combination therapy chloroquine and sulfadoxine-pyrimethamine (CQ/SP) as the first line treatment for uncomplicated malaria...
  18. Prevalence and fitness of drug resistant minority variant mutations in Plasmodium
    Steven Meshnick; Fiscal Year: 2009
    ..Pfcrt76 and dhfr164 fitness will be measured in paired enrollment and recrudescent samples from sulfadoxine-pyrimethamine (SP)- treated patients in Malawi and chloroquine-treated patients in Madagascar...
  19. CLINICAL AND MOLECULAR STUDIES OF DRUG-RESISTANT MALARIA
    MATTHEW DORSEY; Fiscal Year: 2005
    ..2) To evaluate molecular markers of sulfadoxine-pyrimethamine and chloroquine resistance as predictors of clinical treatment outcomes...
  20. Determinants of Drug Resistant Malaria in Nigeria
    Dyann Wirth; Fiscal Year: 2006
    ..falciparum in Nigerian isolates. We also propose to use molecular markers of chloroquine and sulfadoxine-pyrimethamine resistance as a surveillance tool for monitoring changes in the efficacy of these drugs over time in Nigeria...
  21. ANTICOCCIDIAL DRUGS AND DRUG RESISTANCE IN TOXPLASMOSIS
    ELMER PFEFFERKORN; Fiscal Year: 1991
    ..The currently available chemotherapy with pyrimethamine plus a sulfa drug does not always prevent death...
  22. Preclinical Development of PS-26 - an Oxybiguanide
    David Jacobus; Fiscal Year: 2003
    ..Inhibitors of the enzyme dihydrofolate reductase (DHFR) like pyrimethamine have been excellent antimalarials, but point mutations in the target gene compromised its effectiveness...
  23. IMMUNE RESPONSES TO P FALCIPARUM IN HIGHLAND KENYA
    Chandy John; Fiscal Year: 2002
    ..All study subjects will be treated with quinine and sulfadoxime/pyrimethamine, and time to reinfection and level of parasitemia at the time of reinfection will be correlated with duration ..
  24. DRUGS FOR TREATMENT OF PNEUMOCYSTIS CARINII
    James Smith; Fiscal Year: 1993
    ..Pentamidine is an effective chemotherapeutic agent but is highly toxic. Various combinations and analogs of pyrimethamine and sulfadiazine have been used with varying degrees of success...
  25. Population Genetics of Malaria Parasites in African Highlands
    Guiyun Yan; Fiscal Year: 2007
    ..dihydrofolate reductase (DHFR) gene mutations known to confer resistance to antimalarial drug sulfadoxine-pyrimethamine. The proposed research will determine if highland malaria parasites are less diverse than lowland parasites, ..
  26. Randomized, controlled trial of daily trimethoprim-sulfamethoxazole or weekly chl
    CHRISTOPHER PLOWE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  27. DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2002
    ..of in vivo resistance of Plasmodium falciparum malaria to chloroquine and to the combination antifolate drug pyrimethamine-sulfadoxine (PS) is a major threat to public health in Africa...
  28. TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2007
    ..TS shares its mechanism of action with sulfadoxine-pyrimethamine (SP) and other antifolate drugs used to treat malaria...
  29. A randomized, controlled clinical trial of chloroquine as chemoprophylaxis versus
    MIRIAM LAUFER; Fiscal Year: 2008
    ..its efficacy both for preventing infection and treating disease and the antifolate combination sulfadoxine-pyrimethamine (SP) took its place...
  30. Molecular epidemiology of drug resistant malaria
    MIRIAM LAUFER; Fiscal Year: 2008
    ..provided by applicant): In 1993, Malawi was the first country to switch from choloroquine to sulfadoxine-pyrimethamine (SP) as first line anti-malarial therapy due to unacceptably high failure rates with chloroquine...
  31. TREATMENT OF CONGENITAL TOXOPLASMOSIS
    Rima L McLeod; Fiscal Year: 2010
    ..motor, ocular and audiologic outcome will be determined following treatment with one of two dosages of pyrimethamine plus sulfadiazine during the first year of life...
  32. NOVEL APICOMPLEXAN METABOLISM AND ORGANELLE TRANSIT
    Rima McLeod; Fiscal Year: 2005
    ..gondii, its gene regulation, organelle targeting and better characterization of possible novel antimicrobial agent targets in the shikimate pathway and its branches. ..
  33. Drug resistant malaria clinical and laboratory studies
    Sarah Staedke; Fiscal Year: 2005
    ....
  34. Structural Studies of AIDS-Responsive Drugs
    Vivian Cody; Fiscal Year: 2010
    ..These results will help guide the design of species selective inhibitors. Mutagenesis studies will be carried out to test these possibilitiesin the structure-based correlations to help design novel pjDHFRinhibitors. ..
  35. HIV & STI Transmission Dynamics along Transport Routes Linking the Americas
    KIMBERLY BROUWER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  36. Single Agents with Designed Combination Chemotherapy Potential
    Aleem Gangjee; Fiscal Year: 2010
    ..abstract_text> ..
  37. DRUG RESISTANCE IN MALARIA
    CAROL SIBLEY; Fiscal Year: 2002
    ..When completed their experiments will provide a detailed understanding of the mutations that modify function of the Pf-DHFR and Pf-DHPS enzymes or sensitivity of the enzymes to antifolate drugs. ..
  38. Plainning malaria training in Zambia
    Thomas Eisele; Fiscal Year: 2009
    ..Tailoring a sustainable program using appropriate technology and a framework of collaboration in support of PMI activities will greatly increase the likelihood of controlling, and perhaps eventually eliminating, malaria in Zambia. ..
  39. Antitumor Antimitotics That Reverse Tumor Resistance
    Aleem Gangjee; Fiscal Year: 2010
    ..The study will also further define the mechanism of action of the novel series and could afford agents for clinical use. ..
  40. Alpha Folate Receptor Mediated GARFTase Inhibitors as Selective Antitumor Agents
    Aleem Gangjee; Fiscal Year: 2010
    ....
  41. Novel, P. jirovecii Specific Antipneumocystis Agents
    Aleem Gangjee; Fiscal Year: 2009
    ..These agents could be used alone or in combination to treat PCP thus providing novel agents against a new target. ..
  42. Host Polymorphisms and Uncomplicated Malaria
    Sunil Parikh; Fiscal Year: 2008
    ..Parikh will be able to utilize modern molecular epidemiology techniques to investigate human genetic factors underlying susceptibility to malaria and he will be well equipped for a career in academic research. ..
  43. Third Generation Antiopportunistic Agents
    Aleem Gangjee; Fiscal Year: 2003
    ..Screening against tuberculosis (NIAID) and tumor cells in culture (NCI) is also proposed. ..
  44. NOVEL NONINDUCIBLE THYMIDYLATE SYNTHASE INHIBITORS
    Aleem Gangjee; Fiscal Year: 2004
    ....
  45. YEAST MODELS OF DRUG-RESISTANT PNEUMOCYSTIS CARINII
    Steven Meshnick; Fiscal Year: 2004
    ..Ultimately, it is hoped that the results of this study will facilitate the rational use of antipneumocystis drugs. ..
  46. Bladder Cancer and Urinary Schistosomiasis in Ghana
    Clive Shiff; Fiscal Year: 2004
    ..abstract_text> ..
  47. MALARIA AND HIV IN PREGNANT WOMEN IN MALAWI
    Steven Meshnick; Fiscal Year: 2005
    ..The results of this study will have important implications for designing public health program s for antenatal care in African and should promote our understanding of the pathogenesis of MTCT. ..
  48. Routes of Transmission of HIV in Malawian Mothers
    Steven Meshnick; Fiscal Year: 2006
    ..Thus, the results of this project will suggest a comprehensive model of the vector, the route, and the maternal factors associated with HIV vertical transmission. ..
  49. MOLECULAR EVOLUTION OF P. FALCIPARUM AND P VIVAX
    Ananias Escalante; Fiscal Year: 2003
    ....
  50. Congenital and neonatal malaria in Mali
    Abdoulaye Djimde; Fiscal Year: 2006
    ..research grant ..
  51. Novel Single, Dual and Multitargeted Inhibitors of RTKs
    Aleem Gangjee; Fiscal Year: 2007
    ..abstract_text> ..
  52. Antifolates as Antimalarial Drugs
    CAROL SIBLEY; Fiscal Year: 2007
    ..inhibitors is selected can extend the useful therapeutic life of currently available antifolate drugs like pyrimethamine. More important, these studies have also shown that a third generation antifolate, WR99210, holds great ..
  53. co-Trimoxazole in Zambian Infants (TZI)
    CHRISTOPHER GILL; Fiscal Year: 2007
    ..the cessation of TMP-SMZ prophylaxis? 3) Will TMP-SMZ exposure increase rates of resistance to sulfadoxine-pyrimethamine, a leading antimalarial that is cross-tolerant with TMP-SMZ? These questions will be answered by comparing ..
  54. Burden of Malaria in Pregnancy in India
    Davidson Hamer; Fiscal Year: 2007
    ..The information generated by the study will also be instrumental in the development of new programs for preventing and mitigating the impact of MIP in India. [unreadable] [unreadable] [unreadable]..
  55. GENETIC DISSECTION OF TOXOPLASMA GONDII
    David Roos; Fiscal Year: 2008
    ..and similar mutants isolated in the lab will be screened for differences in sensitivity to combined pyrimethamine/sulfonamide treatment (in addition to sensitivity to pyrimethamine or sulfa alone), and examined for possible ..
  56. Halogenated Xanthones as Antimalarial Agents
    Michael Riscoe; Fiscal Year: 2006
    ..Since heme is an immutable biomolecule, it is difficult to envision any simple mutation that could lead to resistance. ..
  57. Molecular Epidemiology of Primary CMV Infection
    RAVIT BOGER; Fiscal Year: 2008
    ..This application will improve our understanding of acute CMV infection and will open new research directions in vaccine development. . [unreadable] [unreadable] [unreadable] [unreadable]..
  58. STRUCTURE BASED ANALOGS AS ANTIOPPORTUNISTIC AGENTS
    Aleem Gangjee; Fiscal Year: 2001
    ..The analogues synthesized will also be submitted for screening against tuberculosis (NIAID) parasitic diseases (WHO) and tumor cells in culture (NCI). ..