Genomes and Genes
Summary: One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.
Publications323 found, 100 shown here
- Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trialsJohn J Aponte
Barcelona Centre for International Health Research, Hospital Clinic, University of Barcelona, Barcelona, Spain
Lancet 374:1533-42. 2009Intermittent preventive treatment (IPT) is a promising strategy for malaria control in infants. We undertook a pooled analysis of the safety and efficacy of IPT in infants (IPTi) with sulfadoxine-pyrimethamine in Africa.
- Intermittent preventive therapy for malaria during pregnancy using 2 vs 3 or more doses of sulfadoxine-pyrimethamine and risk of low birth weight in Africa: systematic review and meta-analysisKassoum Kayentao
Liverpool School of Tropical Medicine, Liverpool, United Kingdom
JAMA 309:594-604. 2013Intermittent preventive therapy with sulfadoxine-pyrimethamine to control malaria during pregnancy is used in 37 countries in sub-Saharan Africa, and 31 of those countries use the standard 2-dose regimen...
- Coverage of malaria protection in pregnant women in sub-Saharan Africa: a synthesis and analysis of national survey dataAnna Maria van Eijk
Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK
Lancet Infect Dis 11:190-207. 2011Insecticide-treated nets and intermittent preventive treatment with sulfadoxine-pyrimethamine are recommended for the control of malaria during pregnancy in endemic areas in Africa, but there has been no analysis of coverage data at a ..
- Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in MalawiJames G Kublin
Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
J Infect Dis 187:1870-5. 2003In 1993, Malawi became the first African country to replace chloroquine with sulfadoxine-pyrimethamine nationwide in response to high rates of chloroquine-resistant falciparum malaria...
- Intercontinental spread of pyrimethamine-resistant malariaCally Roper
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Science 305:1124. 2004Here we present molecular evidence demonstrating that malaria parasites bearing high-level pyrimethamine resistance originally arrived in Africa from southeast Asia...
- Options for the delivery of intermittent preventive treatment for malaria to children: a community randomised trialMargaret Kweku
London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS ONE 4:e7256. 2009..We have evaluated the coverage of IPTc that can be achieved by two different delivery systems in Ghana...
- Molecular markers of resistance to sulphadoxine-pyrimethamine one year after implementation of intermittent preventive treatment of malaria in infants in MaliAlassane Dicko
Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, PO Box 1805 Bamako, Mali
Malar J 9:9. 2010Intermittent preventive treatment in infants (IPTi) with sulphadoxine-pyrimethamine (SP) given during routine vaccinations is efficacious in preventing malaria disease and shows no interaction with the vaccines...
- Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Burkina Faso: a randomised, double-blind, placebo-controlled trialAmadou T Konate
Centre National de Recherche et de Formation sur Paludisme, Ouagadougou, Burkina Faso
PLoS Med 8:e1000408. 2011....
- Chloroquine resistance before and after its withdrawal in KenyaLeah Mwai
Kenya Medical Research Institute Wellcome Trust Collaborative Research Programme, Kilifi, Kenya
Malar J 8:106. 2009..Changes to those that occurred in the dihydrofolate reductase gene (dhfr) that confers resistance to the replacement drug, pyrimethamine/sulphadoxine were also compared.
- High resistance of Plasmodium falciparum to sulphadoxine/pyrimethamine in northern Tanzania and the emergence of dhps resistance mutation at Codon 581Samwel Gesase
National Institute for Medical Research, Tanga Centre, Tanga, Tanzania
PLoS ONE 4:e4569. 2009Sulphadoxine-pyrimethamine (SP) a widely used treatment for uncomplicated malaria and recommended for intermittent preventive treatment of malaria in pregnancy, is being investigated for intermittent preventive treatment of malaria in ..
- Impact of intermittent preventive treatment with sulphadoxine-pyrimethamine targeting the transmission season on the incidence of clinical malaria in children in MaliAlassane Dicko
Malaria Research and Training Center, Departments of Epidemiology of Parasitic Diseases, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, P O Box 1805, Bamako, Mali
Malar J 7:123. 2008..However in most areas malaria morbidity and mortality remain high in older children...
- A randomized placebo-controlled trial of intermittent preventive treatment in pregnant women in the context of insecticide treated nets delivered through the antenatal clinicClara Menendez
Barcelona Center for International Health Research CRESIB and Department of Pathology Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
PLoS ONE 3:e1934. 2008..Current recommendations to prevent malaria in African pregnant women rely on insecticide treated nets (ITNs) and intermittent preventive treatment (IPTp). However, there is no information on the safety and efficacy of their combined use...
- Drug coverage in treatment of malaria and the consequences for resistance evolution--evidence from the use of sulphadoxine/pyrimethamineAllen L Malisa
Department of Biological Sciences, Faculty of Science, Sokoine University of Agriculture, SUA, PO Box 3038, Morogoro, Tanzania
Malar J 9:190. 2010..These models show that where the basis of resistance is multigenic, the effects of selection can be moderated by high recombination rates, which disrupt the associations between co-selected resistance genes...
- Intermittent treatment to prevent pregnancy malaria does not confer benefit in an area of widespread drug resistanceWhitney E Harrington
Malaria Program, Seattle Biomedical Research Institute, Seattle, Washington, USA
Clin Infect Dis 53:224-30. 2011Millions of African women receive sulfadoxine-pyrimethamine (SP) as intermittent preventive treatment during pregnancy (IPTp) to avoid poor outcomes that result from malaria...
- Intermittent preventive treatment of malaria during pregnancy: a qualitative study of knowledge, attitudes and practices of district health managers, antenatal care staff and pregnant women in Korogwe District, North-Eastern TanzaniaGodfrey Mubyazi
National Institute for Medical Research, Ubwari Research Station, P O Box 81, Muheza, Tanzania
Malar J 4:31. 2005..This study assesses the knowledge, attitudes and practices of these groups in relation to malaria control with emphasis on IPTp services...
- Return of chloroquine antimalarial efficacy in MalawiMiriam K Laufer
University of Maryland School of Medicine, Baltimore, MD 21201, USA
N Engl J Med 355:1959-66. 2006..1993, Malawi became the first country in Africa to replace chloroquine with the combination of sulfadoxine and pyrimethamine for the treatment of malaria. At that time, the clinical efficacy of chloroquine was less than 50%...
- Competitive facilitation of drug-resistant Plasmodium falciparum malaria parasites in pregnant women who receive preventive treatmentW E Harrington
Seattle Biomedical Research Institute, 307 Westlake Avenue N, Seattle, WA 98109, USA
Proc Natl Acad Sci U S A 106:9027-32. 2009..However, parasites resistant to the IPTp drug sulfadoxine-pyrimethamine (SP) have emerged worldwide, and infections with mixed resistant and susceptible parasites are exacerbated by ..
- Efficacy, safety, and selection of molecular markers of drug resistance by two ACTs in MaliAbdoulaye A Djimde
Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto Stomatology, University of Bamako, Bamako, Mali
Am J Trop Med Hyg 78:455-61. 2008..the efficacy and safety of artesunate (AS) + amodiaquine (AQ, 3 days) versus AS (3 days) + sulfadoxine-pyrimethamine (SP, single dose) versus AS monotherapy (5 days) in Southern Mali...
- Reaching the Abuja target for intermittent preventive treatment of malaria in pregnancy in African women: a review of progress and operational challengesJenny Hill
Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK
Trop Med Int Health 11:409-18. 2006....
- Prevalence of molecular markers of Plasmodium falciparum resistance to sulfadoxine-pyrimethamine during the intermittent preventive treatment in infants coupled with the expanded program immunization in SenegalBabacar Faye
Department of Parasitology, Faculty of de Medicine, Cheikh Anta Diop University of Dakar, Dakar, Senegal
Parasitol Res 109:133-8. 2011Several studies have shown the efficacy of the intermittent preventive treatment (IPT) using sulfadoxine-pyrimethamine (SP) coupled with the expanded program of immunization (EPI) in infants...
- Effectiveness of intermittent preventive treatment with sulfadoxine-pyrimethamine during pregnancy on maternal and birth outcomes in Machinga district, MalawiJulie Gutman
Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia 30322, USA
J Infect Dis 208:907-16. 2013..Despite increasing prevalence of malarial parasite resistance to sulfadoxine-pyrimethamine (SP), SP continues to be recommended for intermittent preventive treatment in pregnancy (IPTp).
- Intermittent screening and treatment versus intermittent preventive treatment of malaria in pregnancy: a randomised controlled non-inferiority trialHarry Tagbor
Department of Community Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
PLoS ONE 5:e14425. 2010..treatment of malaria in pregnancy (IPTp) may be compromised by the spread of resistance to sulphadoxine/pyrimethamine (SP) across Africa...
- Drug resistance maps to guide intermittent preventive treatment of malaria in African infantsInbarani Naidoo
London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
Parasitology 138:1469-79. 2011Intermittent preventive treatment of infants (IPTi) with sulphadoxine pyrimethamine (SP) is recommended as an additional malaria control intervention in high transmission areas of sub-Saharan Africa, provided its protective efficacy is ..
- Stepwise acquisition of pyrimethamine resistance in the malaria parasiteElena R Lozovsky
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 106:12025-30. 2009The spread of high-level pyrimethamine resistance in Africa threatens to curtail the therapeutic lifetime of antifolate antimalarials...
- The cost-effectiveness of intermittent preventive treatment for malaria in infants in Sub-Saharan AfricaLesong Conteh
Swiss Tropical and Public Health Institute, Basel, Switzerland
PLoS ONE 5:e10313. 2010..To date, there have been limited data on the cost-effectiveness of this strategy using sulfadoxine pyrimethamine (SP) and no published data on cost-effectiveness using other antimalarials.
- Intermittent preventive treatment with sulphadoxine-pyrimethamine is effective in preventing maternal and placental malaria in Ibadan, south-western NigeriaCatherine O Falade
Department of Clinical Pharmacology, University College Hospital, Ibadan, Nigeria
Malar J 6:88. 2007Intermittent preventive treatment with sulphadoxine-pyrimethamine (IPT-SP) is currently the recommended regimen for prevention of malaria in pregnancy in endemic areas...
- Effectiveness of antenatal clinics to deliver intermittent preventive treatment and insecticide treated nets for the control of malaria in pregnancy in KenyaJenny Hill
Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
PLoS ONE 8:e64913. 2013..strategy for sub-Saharan Africa of intermittent-preventive-treatment (IPTp) with two doses of sulphadoxine-pyrimethamine (SP) and insecticide-treated-nets (ITNs) in pregnancy is low...
- Prevalence of resistance associated polymorphisms in Plasmodium falciparum field isolates from southern PakistanNajia Karim Ghanchi
Malaria Research Lab, Infectious Diseases Unit, Department of Medicine, Karolinska University Hospital Karolinska Institutet, Retziusväg 10, Stockholm, Sweden
Malar J 10:18. 2011..The aim of this study was, therefore, to determine the prevalence of P. falciparum resistance associated polymorphisms in field isolates from southern Pakistan...
- Temporal trends of sulphadoxine-pyrimethamine (SP) drug-resistance molecular markers in Plasmodium falciparum parasites from pregnant women in western KenyaNnaemeka C Iriemenam
Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA 30329 4018, USA
Malar J 11:134. 2012Resistance to sulphadoxine-pyrimethamine (SP) in Plasmodium falciparum parasites is associated with mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes and has spread worldwide...
- Evidence of selective sweeps in genes conferring resistance to chloroquine and pyrimethamine in Plasmodium falciparum isolates in IndiaTonya Mixson-Hayden
Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, 4770 Buford Highway, MS F 12, Chamblee, GA 30341, USA
Antimicrob Agents Chemother 54:997-1006. 2010..to a lesser degree, in dhfr, indicating high levels of resistance to chloroquine and evolving resistance to pyrimethamine. Microsatellites surrounding pfcrt indicate that the resistant genotypes (SVMNT) were most similar to those ..
- Antenatal receipt of sulfadoxine-pyrimethamine does not exacerbate pregnancy-associated malaria despite the expansion of drug-resistant Plasmodium falciparum: clinical outcomes from the QuEERPAM studySteve M Taylor
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, 27599, USA
Clin Infect Dis 55:42-50. 2012Antenatal intermittent preventive therapy with 2 doses of sulfadoxine-pyrimethamine (IPTp-SP) is the mainstay of efforts in sub-Saharan Africa to prevent pregnancy-associated malaria (PAM)...
- In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in AfricaChristin Sisowath
Infectious Diseases Unit, Department of Medicine and Karolinska Institutet, Stockholm, Sweden
J Infect Dis 199:750-7. 2009..Identification of drug-specific parasite determinants that contribute to treatment failures will provide important tools for the detection and surveillance of AL resistance...
- Pharmacokinetic properties of sulfadoxine-pyrimethamine in pregnant womenHarin A Karunajeewa
School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
Antimicrob Agents Chemother 53:4368-76. 2009To determine the pharmacokinetic disposition of sulfadoxine (SDOX) and pyrimethamine (PYR) when administered as intermittent presumptive treatment during pregnancy (IPTp) for malaria, 30 Papua New Guinean women in the second or third ..
- A trial of combination antimalarial therapies in children from Papua New GuineaHarin A Karunajeewa
School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia
N Engl J Med 359:2545-57. 2008..Malaria control is difficult where there is intense year-round transmission of multiple plasmodium species, such as in Papua New Guinea...
- Two strategies for the delivery of IPTc in an area of seasonal malaria transmission in the Gambia: a randomised controlled trialKalifa A Bojang
Medical Research Council Laboratories, Banjul, The Gambia
PLoS Med 8:e1000409. 2011..In rural areas, RCH trekking teams provide most of the health care to children under the age of 5 years in the Infant Welfare Clinic, and provide antenatal care for pregnant women...
- Cost effectiveness of seasonal intermittent preventive treatment using amodiaquine & artesunate or sulphadoxine-pyrimethamine in Ghanaian childrenLesong Conteh
London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS ONE 5:e12223. 2010..It is important to determine the costs associated with IPTc delivery via community based volunteers and also the potential savings to health care providers and caretakers due to malaria episodes averted as a consequence of IPTc...
- A selective sweep driven by pyrimethamine treatment in southeast asian malaria parasitesShalini Nair
Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
Mol Biol Evol 20:1526-36. 2003..falciparum. Point mutations in dhfr are known to be responsible for resistance to the antimalarial drug pyrimethamine, and resistance to this drug has spread rapidly in Southeast (SE) Asia after its introduction in 1970s...
- Plasmodium falciparum gametocyte carriage in asymptomatic children in western KenyaJ Teun Bousema
Department of Medical Microbiology, University Medical Centre, Nijmegen, The Netherlands
Malar J 3:18. 2004..This study identified factors that influence gametocytaemia in asymptomatic children in the absence and presence of pyrimethamine-sulphadoxine (SP) antimalarial treatment.
- Knowledge of malaria influences the use of insecticide treated nets but not intermittent presumptive treatment by pregnant women in TanzaniaRhoida Y Nganda
Kilimanjaro Christian Medical Centre, PO Box 3010, Moshi, Tanzania
Malar J 3:42. 2004..has recently adopted a policy of intermittent presumptive treatment for pregnant women using sulphadoxine-pyrimethamine (IPTp-SP)...
- Pharmacokinetics of sulfadoxine and pyrimethamine in intermittent preventive treatment of malaria in pregnancyM M Nyunt
Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Clin Pharmacol Ther 87:226-34. 2010..In order to minimize the burden, sulfadoxine-pyrimethamine (SP) is widely used in Africa as an intermittent preventive treatment of malaria in pregnancy (IPTp)...
- Use of antenatal care services and intermittent preventive treatment for malaria among pregnant women in Blantyre District, MalawiTimothy H Holtz
Malaria Epidemiology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Trop Med Int Health 9:77-82. 2004..We performed a cluster sample survey to study the use of sulfadoxine-pyrimethamine (SP) for IPT among recently pregnant women in February 2000 in Blantyre District, Malawi...
- (Sub)microscopic Plasmodium falciparum gametocytaemia in Kenyan children after treatment with sulphadoxine-pyrimethamine monotherapy or in combination with artesunatePetra Schneider
Radboud University Nijmegen Medical Centre, Medical Microbiology 268, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
Int J Parasitol 36:403-8. 2006..falciparum malaria after treatment with sulphadoxine-pyrimethamine (SP) or a combination of SP and artesunate (SP+AS), in a 28-days drug efficacy study...
- A trial of the efficacy, safety and impact on drug resistance of four drug regimens for seasonal intermittent preventive treatment for malaria in Senegalese childrenCheikh Sokhna
Institut de Recherche pour le Developpement, Dakar, Senegal
PLoS ONE 3:e1471. 2008..A trial of seasonal intermittent preventive treatment (IPT) with sulfadoxine-pyrimethamine (SP) and a single dose of artesunate (AS) showed an 86% reduction in the incidence of malaria in Senegal but ..
- Association of genetic mutations in Plasmodium vivax dhfr with resistance to sulfadoxine-pyrimethamine: geographical and clinical correlatesM Imwong
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Antimicrob Agents Chemother 45:3122-7. 2001..0001). The dhfr PCR products of P. vivax from 32 Thai patients treated with the antifolate sulfadoxine-pyrimethamine (S-P) were investigated. All samples showed either double (53%) or triple (47%) mutations...
- Validity of self-reported use of sulphadoxine-pyrimethamine intermittent presumptive treatment during pregnancy (IPTp): a cross-sectional studyFatuma Namusoke
Department of Biochemistry, Makerere University, Kampala, Uganda
Malar J 11:310. 2012..The WHO recommends use of sulphadoxine-pyrimethamine (SP) for intermittent preventive treatment of malaria during pregnancy (IPTp) in endemic areas...
- Following the path of most resistance: dhps K540E dispersal in African Plasmodium falciparumInbarani Naidoo
London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
Trends Parasitol 26:447-56. 2010..By contrast, resistance to sulphadoxine-pyrimethamine (SPR) has emerged during an era of molecular surveillance, and the changing prevalence of SPR conferred by ..
- Selection of pfdhfr/pfdhps alleles and declining artesunate/sulphadoxine-pyrimethamine efficacy against Plasmodium falciparum eight years after deployment in eastern SudanNahla B Gadalla
Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, UK
Malar J 12:255. 2013Artesunate/sulphadoxine-pyrimethamine (AS/SP) has been the first-line treatment for falciparum malaria in Sudan since 2004. The impact of this combination on anti-malarial resistance-associated molecular markers has not been investigated...
- Efficacy of intermittent preventive treatment with sulfadoxine-pyrimethamine on placental parasitemia in pregnant women in midwestern NigeriaMichael E Aziken
Department of Obstetrics and Gynecology, University of Benin Teaching Hospital, Benin City, Edo State, Nigeria
Int J Gynaecol Obstet 112:30-3. 2011To assess the effect of intermittent preventive treatment with sulfadoxine and pyrimethamine (IPT-SP) on placental parasitemia and maternal and perinatal outcome.
- Intermittent treatment for the prevention of malaria during pregnancy in Benin: a randomized, open-label equivalence trial comparing sulfadoxine-pyrimethamine with mefloquineValérie Briand
Institut de Recherche pour le Developpement, santé de la mère et de l enfant en milieu tropical, Faculte de Pharmacie, 4 avenue de l Observatoire, Paris Cedex 06, France
J Infect Dis 200:991-1001. 2009In the context of the increasing resistance to sulfadoxine-pyrimethamine (SP), we evaluated the efficacy of mefloquine (MQ) for intermittent preventive treatment during pregnancy (IPTp).
- Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in MalawiDavid J Bell
Tropical and Infectious Diseases Unit, Royal Liverpool University Hospital, Liverpool L7 8XP, UK
Malar J 8:204. 2009Sulphadoxine-pyrimethamine (SP) is the only single dose therapy for uncomplicated malaria, but there is widespread resistance...
- Placental malaria among HIV-infected and uninfected women receiving anti-folates in a high transmission area of UgandaPatrick M Newman
School of Medicine, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94131, USA
Malar J 8:254. 2009..daily trimethoprim-sulphamethoxazole (TS) and HIV-uninfected women to receive intermittent sulphadoxine-pyrimethamine (SP)...
- No rebound of morbidity following intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in GabonMartin P Grobusch
Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
J Infect Dis 200:1658-61. 2009In the context of a trial studying intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in Lambaréné, Gabon, children aged 18-30 months were followed up after having received their last dose at an age of 15 ..
- Therapeutic efficacy of chloroquine in Plasmodium vivax from areas with different epidemiological patterns in India and their Pvdhfr gene mutation patternNeena Valecha
Malaria Research Centre ICMR, 22 Sham Nath Marg, Delhi 110 054, India
Trans R Soc Trop Med Hyg 100:831-7. 2006..Although P. vivax has been reported to be inherently resistant to sulfonamide and pyrimethamine, Indian isolates exhibited only double mutations in dhfr in vitro.
- Hitchhiking and selective sweeps of Plasmodium falciparum sulfadoxine and pyrimethamine resistance alleles in a population from central AfricaAndrea M McCollum
Program in Population Biology, Ecology, and Evolution, Emory University, Atlanta, Georgia, USA
Antimicrob Agents Chemother 52:4089-97. 2008Sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum is encoded by a number of mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhps) genes...
- Antifolates can have a role in the treatment of Plasmodium vivaxVivian N Hawkins
Department of Genome Sciences, University of Washington, Box 355065, Seattle, WA 98195, USA
Trends Parasitol 23:213-22. 2007..vivax is a serious health concern in many regions and is sometimes inadvertently treated with sulfadoxine-pyrimethamine (SP)...
- Seasonal intermittent preventive treatment for the prevention of anaemia and malaria in Ghanaian children: a randomized, placebo controlled trialMargaret Kweku
London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS ONE 3:e4000. 2008..We have investigated the effect of intermittent preventive treatment with sulphadoxine-pyrimethamine or artesunate plus amodiaquine on anaemia and malaria in children in an area of intense, prolonged, seasonal ..
- Randomized trial of 2-dose versus monthly sulfadoxine-pyrimethamine intermittent preventive treatment for malaria in HIV-positive and HIV-negative pregnant women in MalawiScott J Filler
Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Infect Dis 194:286-93. 2006Intermittent preventive treatment during pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) decreases placental malaria parasitemia and associated maternal anemia, premature delivery, and low birth weight...
- Determinants of use of intermittent preventive treatment of malaria in pregnancy: Jinja, UgandaLaura R Sangaré
Department of Global Health, University of Washington, Seattle, Washington, USA
PLoS ONE 5:e15066. 2010..means of preventing malaria during pregnancy is intermittent preventive therapy (IPTp) with sulfadoxine/pyrimethamine (SP)...
- Selection strength and hitchhiking around two anti-malarial resistance genesDenae Nash
Southwest Foundation for Biomedical Research SFBR, San Antonio, TX 78245, USA
Proc Biol Sci 272:1153-61. 2005..mutation in pfcrt conferring resistance to chloroquine (CQ) and 2-4 mutations in dhfr conferring resistance to pyrimethamine. By contrast, we found both wild-type and resistant alleles at both genes in Laos...
- The effect of health care worker training on the use of intermittent preventive treatment for malaria in pregnancy in rural western KenyaP O Ouma
Kenya Medical Research Institute, Centre for Vector Biology and Control Research, Kisumu, Kenya
Trop Med Int Health 12:953-61. 2007In 1998, Kenya adopted intermittent preventive treatment (IPTp) with sulphadoxine-pyrimethamine (SP) for malaria prevention during pregnancy...
- Individual, facility and policy level influences on national coverage estimates for intermittent preventive treatment of malaria in pregnancy in TanzaniaTanya Marchant
Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK
Malar J 7:260. 2008..This investigation measured coverage of IPTp at national level in Tanzania and examined the role of individual, facility, and policy level influences on achieved coverage...
- Therapeutic response of multidrug-resistant Plasmodium falciparum and P. vivax to chloroquine and sulfadoxine-pyrimethamine in southern Papua, IndonesiaA Ratcliff
International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia
Trans R Soc Trop Med Hyg 101:351-9. 2007..resistance in southern Papua, Indonesia, we assessed the therapeutic efficacy of chloroquine plus sulfadoxine-pyrimethamine (CQ+SP) for Plasmodium falciparum infections as well as CQ monotherapy for P. vivax infections...
- Plasmodium falciparum isolates in India exhibit a progressive increase in mutations associated with sulfadoxine-pyrimethamine resistanceAnwar Ahmed
Department of Biotechnology, All India Institute of Medical Sciences, New Delhi 110029 Malaria Research Centre, 22 Sham Nath Marg, New Delhi 110054, India
Antimicrob Agents Chemother 48:879-89. 2004The combination of sulfadoxine-pyrimethamine (SP) is used as a second line of therapy for the treatment of uncomplicated chloroquine-resistant Plasmodium falciparum malaria...
- Duration of protection against clinical malaria provided by three regimens of intermittent preventive treatment in Tanzanian infantsMatthew Cairns
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS ONE 5:e9467. 2010..Understanding the mechanism is essential for development of replacements for sulfadoxine-pyrimethamine (SP) where it is no longer effective...
- Cost-effectiveness of malaria intermittent preventive treatment in infants (IPTi) in Mozambique and the United Republic of TanzaniaGuy Hutton
Swiss Tropical Institute, Basel, Switzerland
Bull World Health Organ 87:123-9. 2009To estimate the cost-effectiveness of malaria intermittent preventive treatment in infants (IPTi) using sulfadoxine-pyrimethamine (SP).
- In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutationSteven M Kiara
Kenya Medical Research Institute KEMRI Wellcome Trust Collaborative Research Program, P O Box 230, 80108 Kilifi, Kenya
Antimicrob Agents Chemother 53:3793-8. 2009We have analyzed the activities of the antifolates pyrimethamine (PM), chlorcycloguanil (CCG), WR99210, trimethoprim (TMP), methotrexate (MTX), and trimetrexate (TMX) against Kenyan Plasmodium falciparum isolates adapted in vitro for ..
- Two-dose versus monthly intermittent preventive treatment of malaria with sulfadoxine-pyrimethamine in HIV-seropositive pregnant Zambian womenDavidson H Hamer
Center for International Health and Development, Boston University School of Public Health, Boston, MA 02118, USA
J Infect Dis 196:1585-94. 2007..However, the optimal dosing regimen in settings in which human immunodeficiency virus (HIV) is highly prevalent among pregnant women remains controversial...
- Access and barriers to measures targeted to prevent malaria in pregnancy in rural KenyaPriscilla W Gikandi
Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Research Programme, Nairobi, Kenya
Trop Med Int Health 13:208-17. 2008..pregnant women from using insecticide-treated nets (ITN) and intermittent presumptive treatment (IPT) with sulphadoxine-pyrimethamine (SP) 5 years after the launch of the national malaria strategy promoting these measures in Kenya.
- Ethnographic study of factors influencing compliance to intermittent preventive treatment of malaria during pregnancy among Yao women in rural MalawiAnnika Launiala
School of Public Health, FIN 33014 University of Tampere, Tampere, Finland
Trans R Soc Trop Med Hyg 101:980-9. 2007..This study discovered several factors affecting IPT. These were: unclear messages about IPT with sulfadoxine-pyrimethamine (SP) from nurses; timing of SP-1; periodic shortages of SP; women's limited understanding of IPT-SP; tendency ..
- Randomized trial of piperaquine with sulfadoxine-pyrimethamine or dihydroartemisinin for malaria intermittent preventive treatment in childrenBadara Cisse
Department of Parasitology and Mycology, Universite Cheikh Anta Diop, Dakar, Senegal
PLoS ONE 4:e7164. 2009..trial to determine whether piperaquine in combination with either dihydroartemisin (DHA) or sulfadoxine-pyrimethamine (SP) is as effective, and better tolerated, than SP plus amodiaquine (AQ), when used for intermittent ..
- Efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria: revisiting molecular markers in an area of emerging AQ and SP resistance in MaliMamadou Tekete
Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Malaria Research and Training Center, Bamako, Mali
Malar J 8:34. 2009To update the National Malaria Control Programme of Mali on the efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria.
- Selection of antifolate-resistant Plasmodium falciparum by sulfadoxine-pyrimethamine treatment and infectivity to Anopheles mosquitoesFabian Mendez
Escuela de Salud Publica, Universidad del Valle, Cali, Colombia
Am J Trop Med Hyg 77:438-43. 2007..DHFR) and dihydropteroate synthase (DHPS) in Plasmodium falciparum are selected by treatment with sulfadoxine pyrimethamine (SP)...
- Parasitological and clinical efficacy of standard treatment regimens against Plasmodium falciparum, P. vivax and P. malariae in Papua New GuineaBlaise Genton
Swiss Tropical Institute, Basel, Switzerland
P N G Med J 48:141-50. 2005..treatment failure (TF) and parasite resistance to amodiaquine (AQ), chloroquine (CQ) and quinine+sulfadoxine/pyrimethamine (Q+SP) for malaria in a rural health centre of the East Sepik Province...
- Intermittent preventive treatment of malaria in pregnancy: at the crossroads of public health policyR Matthew Chico
Department of Disease Control, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
Trop Med Int Health 16:774-85. 2011The intermittent preventive treatment of malaria in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) has been a key component of the focused antenatal care package for nearly a decade, reducing the burden of low birthweight ..
- The efficacy of sulfadoxine-pyrimethamine alone and in combination with chloroquine for malaria treatment in rural Eastern Sudan: the interrelation between resistance, age and gametocytogenesisIshraga E A-Elbasit
Malaria Research Centre, Department of Biochemistry, University of Khartoum, Khartoum, Sudan
Trop Med Int Health 11:604-12. 2006..To compare the efficacy of sulfadoxine-pyremethamine (SP)+chloroquine (CQ) combination treatment against falciparum malaria with SP treatment alone...
- The evolution of pyrimethamine resistant dhfr in Plasmodium falciparum of south-eastern Tanzania: comparing selection under SP alone vs SP+artesunate combinationAllen L Malisa
Sokoine University of Agriculture, Department of Biological Sciences, Faculty of Science, Box 3038, Morogoro, Tanzania
Malar J 10:317. 2011Sulphadoxine-pyrimethamine (SP) resistance is now widespread throughout east and southern Africa and artemisinin compounds in combination with synthetic drugs (ACT) are recommended as replacement treatments by the World Health ..
- Intermittent preventive treatment of malaria in pregnancy (IPTp): do frequent antenatal care visits ensure access and compliance to IPTp in Ugandan rural communities?Richard Ndyomugyenyi
Malaria Control Programme, Ministry of Health, P O Box 7272, Kampala, Uganda
Trans R Soc Trop Med Hyg 104:536-40. 2010..ANC) visits and coverage of intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP), and barriers to IPTp-SP access were examined...
- In vitro susceptibility of various genotypic strains of Toxoplasma gondii to pyrimethamine, sulfadiazine, and atovaquonePascale Meneceur
Laboratory of Parasitology EA 3520, University Denis Diderot, 15 rue de l Ecole de Medecine, 75250 Paris Cedex 06, France
Antimicrob Agents Chemother 52:1269-77. 2008Sulfadiazine, pyrimethamine, and atovaquone are widely used for the treatment of severe toxoplasmosis. Their in vitro activities have been almost exclusively demonstrated on laboratory strains belonging to genotype I...
- Rural Gambian women's reliance on health workers to deliver sulphadoxine-pyrimethamine as recommended intermittent preventive treatment for malaria in pregnancyLoretta Brabin
Academic Unit of Obstetrics and Gynaecology, University of Manchester, Manchester M13 OJH, UK
Malar J 8:25. 2009The use of most anti-malarial medications is restricted during pregnancy, but two doses of sulphadoxine-pyrimethamine are recommended after the first trimester as intermittent preventive treatment in pregnancy (IPTp)...
- HIV and placental infection modulate the appearance of drug-resistant Plasmodium falciparum in pregnant women who receive intermittent preventive treatmentClara Menendez
Barcelona Centre for International Health Research, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
Clin Infect Dis 52:41-8. 2011Factors involved in the development of resistance to sulphadoxine-pyrimethamine (SP) by Plasmodium falciparum, particularly in the context of intermittent preventive treatment during pregnancy (IPTp), are not well known...
- High prevalence of the 437G mutation associated with sulfadoxine resistance among Plasmodium falciparum clinical isolates from Iran, three years after the introduction of sulfadoxine-pyrimethamineSedigheh Zakeri
Malaria and Vector Research Group, Biotechnology Research Center, Pasteur Institute of Iran, Pasteur Avenue, Tehran, Iran
Int J Infect Dis 14:e123-8. 2010..was to determine the frequency of dhfr and dhps resistance-associated haplotypes in Plasmodium falciparum isolates, three years after the introduction of sulfadoxine-pyrimethamine (SP) as the first-line antimalarial treatment in Iran.
- Malaria prevention with IPTp during pregnancy reduces neonatal mortalityClara Menendez
Barcelona Centre for International Health Research CRESIB, Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
PLoS ONE 5:e9438. 2010..Malaria in pregnancy may affect neonatal survival, though no strong evidence exists to support this association...
- Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicityKasia Stepniewska
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
Malar J 7:249. 2008..The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity...
- Patterns of case management and chemoprevention for malaria-in-pregnancy by public and private sector health providers in Enugu state, NigeriaOgochukwu C Onwujekwe
Department of Pharmacy, University of Nigeria Teaching Hospital, Ituku Ozalla, Enugu State, Nigeria
BMC Res Notes 5:211. 2012..Information is required on how to improve its prevention and treatment from both the providers' and consumers' perspectives...
- Prospective randomized trial of trimethoprim/sulfamethoxazole versus pyrimethamine and sulfadiazine in the treatment of ocular toxoplasmosisMasoud Soheilian
Ocular Inflammatory and Uveitis Service, Department of Ophthalmology, and Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ophthalmology 112:1876-82. 2005To compare the efficacy of the classic treatment of ocular toxoplasmosis (pyrimethamine, sulfadiazine, and prednisolone) with a regimen consisting of trimethoprim/sulfamethoxazole (co-trimoxazole) plus prednisolone.
- Plasmodium vivax: prevalence of mutations associated with sulfadoxine-pyrimethamine resistance in Plasmodium vivax clinical isolates from PakistanSedigheh Zakeri
Malaria and Vector Research Group, Biotechnology Research Center, Pasteur Institute of Iran, Pasteur Avenue, PO BOX 1316943551, Tehran, Iran
Exp Parasitol 127:167-72. 2011..study was to investigate the frequency of SNPs-haplotypes of dhfr and dhps genes associated to sulfadoxine-pyrimethamine (SP) resistance in Plasmodium vivax clinical isolates circulating in a malaria endemic area, Pakistan...
- Frequency distribution of antimalarial drug-resistant alleles among isolates of Plasmodium falciparum in Bangui, Central African RepublicDidier Menard
Pasteur Institute of Bangui, Bangui, Central African Republic
Am J Trop Med Hyg 74:205-10. 2006..frequency distribution of mutant alleles of genes associated with resistance to chloroquine and sulfadoxine-pyrimethamine in Plasmodium falciparum isolates in Bangui, Central African Republic. Mutant alleles of the P...
- Use of antenatal care, maternity services, intermittent presumptive treatment and insecticide treated bed nets by pregnant women in Luwero district, UgandaMpungu S Kiwuwa
Clinical Epidemiology Unit, Faculty of Medicine, Makerere University, Uganda
Malar J 7:44. 2008..of insecticide-treated nets (ITNs) and introduction of intermittent preventive treatment with sulphadoxine-pyrimethamine for pregnant women (IPTp-SP) as a national policy in 2000...
- Markers of sulfadoxine-pyrimethamine-resistant Plasmodium falciparum in placenta and circulation of pregnant womenFrank P Mockenhaupt
Institute of Tropical Medicine and International Health, Spandauer Damm 130, 14050 Berlin, Germany
Antimicrob Agents Chemother 51:332-4. 2007..of Plasmodium falciparum in pregnancy may impair the usefulness of molecular markers of sulfadoxine-pyrimethamine resistance...
- Differences in selective pressure on dhps and dhfr drug resistant mutations in western KenyaAndrea M McCollum
Program in Population Biology, Ecology, and Evolution, Emory University, Atlanta, GA, USA
Malar J 11:77. 2012..This study describes the dynamics of strong selection for mutations conferring resistance against sulphadoxine-pyrimethamine (SP), a combination therapy, in western Kenya between 1992 and 1999, just before SP became first-line therapy (..
- Bottlenecks for high coverage of intermittent preventive treatment in pregnancy: the case of adolescent pregnancies in rural Burkina FasoKoen Peeters Grietens
Prince Leopold Institute for Tropical Medicine, Antwerp, Belgium
PLoS ONE 5:e12013. 2010....
- Randomized trial of intravitreal clindamycin and dexamethasone versus pyrimethamine, sulfadiazine, and prednisolone in treatment of ocular toxoplasmosisMasoud Soheilian
Department of Ophthalmology and Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti Medical University, Tehran, Iran
Ophthalmology 118:134-41. 2011..To compare the efficacy of intravitreal injection of clindamycin and dexamethasone with classic treatment for ocular toxoplasmosis...
- Field evaluation of the intermittent preventive treatment of malaria during pregnancy (IPTp) in Benin: evolution of the coverage rate since its implementationTania C D A d'Almeida
Faculté des Sciences de Santé, Cotonou, Benin
Parasit Vectors 4:108. 2011..of compliance problems and drug resistance, was replaced by intermittent preventive treatment with sulfadoxine-pyrimethamine (ITPp-SP) with two single doses taken after 16 weeks of amenorrhea, at least 4 weeks apart...
- The fitness of drug-resistant malaria parasites in a rodent model: multiplicity of infectionS Huijben
Department of Biology, Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA 16802, USA
J Evol Biol 24:2410-22. 2011..This would greatly simplify the computational problems of adequately capturing within-host ecology in models of drug resistance evolution in malaria...
- Mother-to-child transmission of HIV-1: association with malaria prevention, anaemia and placental malariaD Naniche
Barcelona Center for International Health Research CRESIB, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
HIV Med 9:757-64. 2008..Prevention of malaria in pregnancy could thus potentially affect MTCT of HIV. We studied the impact of intermittent preventive treatment during pregnancy (IPTp) on HIV-1 MTCT in southern Mozambique...
- Primaquine clears submicroscopic Plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunateSeif Shekalaghe
Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
PLoS ONE 2:e1023. 2007P. falciparum gametocytes may persist after treatment with sulphadoxine-pyrimethamine (SP) plus artesunate (AS) and contribute considerably to malaria transmission...
- A shared Asian origin of the triple-mutant dhfr allele in Plasmodium falciparum from sites across AfricaOumou Maïga
Universite Paris Descartes, Paris, France
J Infect Dis 196:165-72. 2007Usefulness of sulfadoxine-pyrimethamine as first-line therapy for uncomplicated Plasmodium falciparum malaria and intermittent preventive treatment in pregnancy throughout sub-Saharan Africa is compromised by the spread of dhfr alleles ..
- Placental malaria and low birth weight in pregnant women living in a rural area of Burkina Faso following the use of three preventive treatment regimensAlfred B Tiono
Centre National de Recherche et de Formation sur le Paludisme, Ministere de la Sante, Ouagadougou, Burkina Faso
Malar J 8:224. 2009..It compares the efficacy of two IPT regimens, using chloroquine (CQ) or sulphadoxine/pyrimethamine (SP), with the classical chemoprophylaxis regimen using CQ in reducing the adverse outcomes of malaria ..
- Novel point mutations in the dihydrofolate reductase gene of Plasmodium vivax: evidence for sequential selection by drug pressureMallika Imwong
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, National Science and Technology Development Agency, Bangkok, Thailand
Antimicrob Agents Chemother 47:1514-21. 2003..Highly mutated genes carry the S-->T rather than the S-->N mutation at residue 117. Mutations at residues 57 and 61 then occur, followed by a fifth mutation at residue 13...
- A trial of intermittent preventive treatment and home-based management of malaria in a rural area of The GambiaSanie Sesay
Medical Research Council Laboratories, Banjul, The Gambia
Malar J 10:2. 2011..The potential benefits of combining IPT in children (IPTc) with home management of malaria (HMM) was investigated...
- Randomized controlled trial of fosmidomycin-clindamycin versus sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malariaSunny Oyakhirome
Institute for Tropical Medicine, Department for Parasitology, University of Tubingen, Wilhelmstrasse 27, Tubingen, Germany
Antimicrob Agents Chemother 51:1869-71. 2007..therapy given every 12 h for 3 days was compared with a standard single oral dose of sulfadoxine-pyrimethamine. The two treatments showed comparably good tolerabilities and had an identical high degree of efficacy of 94% ..
- TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWICHRISTOPHER PLOWE; Fiscal Year: 2003..TS shares its mechanism of action with pyrimethamine-sulfadoxine (PS) and other antifolate drugs used to treat malaria, which is responsible for an estimated 2...
- Molecular epidemiology of drug resistance and population genetic structure of PlaFangli Lu; Fiscal Year: 2013..Sulfadoxine-pyrimethamine (SP) targets the dhfr and dhps genes of P...
- Development of a Chloroquine Replacement DrugMICHAEL KEVIN RISCOE; Fiscal Year: 2010..to multiple drugs including: the quinolines - chloroquine, quinine, and mefloquine;the antifolates - pyrimethamine and sulfadoxine;and the anti-respiratory combination of atovaquone and proguanil...
- Institutional Collaboration between LSTM and CDC and Prevention on Malaria(U01)FEIKO OLAF TER KUILE; Fiscal Year: 2013..central coordination of a multi-country observational study in Africa to determine the effect of sulfadoxine-pyrimethamine (SP) resistance on intermittent preventive treatment in pregnancy (IPTp) effectiveness, and two studies in ..
- Optimization of pyrimidinyl prodrugs (PYPs) for malaria chemotherapyPRADIPSINH RATHOD; Fiscal Year: 2009..quantitative in vitro studies of safety versus potency suggest that PYP1, as is, has comparable selectivity to pyrimethamine. It can be even better with some improved pharmacokinetics and controlled drug release...
- Inflammation, Anemia and Respiratory Distress in Mothers and Infants with MalariaWHITNEY ELIZABETH HARRINGTON; Fiscal Year: 2011..pregnant women in Africa receive intermittent presumptive treatment (IPTp) with the antimalarial sulfadoxine-pyrimethamine (SP) each year to prevent P...
- PfSPZ Challenge with Chemoprophylaxis: Phase 1 Trial to Assess Liver Stage DrugSTEPHEN LEV HOFFMAN; Fiscal Year: 2013..1) the pilot trial phase will determine the optimal timing after PfSPZ inoculation to administer the drug pyrimethamine that is approved by FDA for prophylaxis and treatment of susceptible P...
- Research Activities in Support of Malaria Prevention and Control in Uganda (PMI)MOSES ROBERT KAMYA; Fiscal Year: 2013..2) We will perform a clinical trial to measure the in vivo efficacy of sulfadoxine-pyrimethamine (SP) for the clearance of asymptomatic parasitemia in pregnant women as a means of evaluating the ..
- Genome Surveillance for drug resistant malariaDyann F Wirth; Fiscal Year: 2010..the great utility of smaller scale studies by others that identified the genes responsible for chloroquine and pyrimethamine resistance...
- CRYPTOSPORIDIUM DHFR AS A CHEMOTHERAPEUTIC TARGETRichard Nelson; Fiscal Year: 1992..However, DHFR also varies greatly among protozoa and the available inhibitors (pyrimethamine, trimethoprim, proguanil) bind poorly to some protozoan DHFRs (Leishmania, Trypanosoma, and Eimeria) and very ..
- IMPACT OF TS PROPHYLAXIS ON ANTIFOLATE RESISTANT MALARIAJames Kublin; Fiscal Year: 2000..TS shares its mechanism of action with pyrimethamine-sulfadoxine (PS) and other antifolate drugs used to treat malaria...
- LIPOPHILIC ANTIFOLATES AND AIDS OPPORTUNISTIC INFECTIONSAndre Rosowsky; Fiscal Year: 2004..high potency of trimetrexate (TMQ) and piritrexim (PTX) with the species selectivity of trimethoprim (TMP) and pyrimethamine (PM) against Pc, Tg, or Cp dihydrofolate reductase (DHFR) versus rodent or human DHFR...
- Preventing Pregnancy Malaria: Maternal-Infant OutcomesMichal Fried; Fiscal Year: 2009..In the studies proposed here, three new IPTp regimens (chlorproguanil-dapsone (LapDap);mefloquine;sulfadoxine-pyrimethamine (SP) + azithromycin) will be compared to the currently recommended regimen (SP alone) for their efficacy and ..
- SP resistance markers & falciparum malaria transmissionFabian Mendez; Fiscal Year: 2004..However, resistance to the combination antifolate drug sulfadoxine-pyrimethamine (SP) has remained low in Colombia in contrast to high rates of SP failure elsewhere in the region...
- A Phase l Study of Pyrimethamine in patients with GM-2 GangliosidosisBijan Almassian; Fiscal Year: 2007..unreadable] [unreadable] In 2006, ExSAR applied for orphan drug designation from the FDA for pyrimethamine for the treatment of patients affected with late-onset GM2-gangliosidosis...
- Synthesis and Evaluation of Novel Antimalarial AgentsShuren Zhu; Fiscal Year: 2005..falciparum malaria parasite clones: W2 (susceptible to mefloquine but resistant to chloroquine, sulfadoxine, pyrimethamine, and quinine) and D6 (resistant to mefloquine but susceptible to chloroquine, sulfadoxine, pyrimethamine and ..
- Molecular epidemiology of sulfadoxine-pyrimethamineThomas Egwang; Fiscal Year: 2006..The government interim drug policy recommends the use of the combination therapy chloroquine and sulfadoxine-pyrimethamine (CQ/SP) as the first line treatment for uncomplicated malaria...
- Prevalence and fitness of drug resistant minority variant mutations in PlasmodiumSteven Meshnick; Fiscal Year: 2009..Pfcrt76 and dhfr164 fitness will be measured in paired enrollment and recrudescent samples from sulfadoxine-pyrimethamine (SP)- treated patients in Malawi and chloroquine-treated patients in Madagascar...
- CLINICAL AND MOLECULAR STUDIES OF DRUG-RESISTANT MALARIAMATTHEW DORSEY; Fiscal Year: 2005..2) To evaluate molecular markers of sulfadoxine-pyrimethamine and chloroquine resistance as predictors of clinical treatment outcomes...
- Determinants of Drug Resistant Malaria in NigeriaDyann Wirth; Fiscal Year: 2006..falciparum in Nigerian isolates. We also propose to use molecular markers of chloroquine and sulfadoxine-pyrimethamine resistance as a surveillance tool for monitoring changes in the efficacy of these drugs over time in Nigeria...
- ANTICOCCIDIAL DRUGS AND DRUG RESISTANCE IN TOXPLASMOSISELMER PFEFFERKORN; Fiscal Year: 1991..The currently available chemotherapy with pyrimethamine plus a sulfa drug does not always prevent death...
- Preclinical Development of PS-26 - an OxybiguanideDavid Jacobus; Fiscal Year: 2003..Inhibitors of the enzyme dihydrofolate reductase (DHFR) like pyrimethamine have been excellent antimalarials, but point mutations in the target gene compromised its effectiveness...
- IMMUNE RESPONSES TO P FALCIPARUM IN HIGHLAND KENYAChandy John; Fiscal Year: 2002..All study subjects will be treated with quinine and sulfadoxime/pyrimethamine, and time to reinfection and level of parasitemia at the time of reinfection will be correlated with duration ..
- DRUGS FOR TREATMENT OF PNEUMOCYSTIS CARINIIJames Smith; Fiscal Year: 1993..Pentamidine is an effective chemotherapeutic agent but is highly toxic. Various combinations and analogs of pyrimethamine and sulfadiazine have been used with varying degrees of success...
- Population Genetics of Malaria Parasites in African HighlandsGuiyun Yan; Fiscal Year: 2007..dihydrofolate reductase (DHFR) gene mutations known to confer resistance to antimalarial drug sulfadoxine-pyrimethamine. The proposed research will determine if highland malaria parasites are less diverse than lowland parasites, ..
- Randomized, controlled trial of daily trimethoprim-sulfamethoxazole or weekly chlCHRISTOPHER PLOWE; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- DRUG-RESISTANT MALARIA IN MALAWICHRISTOPHER PLOWE; Fiscal Year: 2002..of in vivo resistance of Plasmodium falciparum malaria to chloroquine and to the combination antifolate drug pyrimethamine-sulfadoxine (PS) is a major threat to public health in Africa...
- TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWICHRISTOPHER PLOWE; Fiscal Year: 2007..TS shares its mechanism of action with sulfadoxine-pyrimethamine (SP) and other antifolate drugs used to treat malaria...
- A randomized, controlled clinical trial of chloroquine as chemoprophylaxis versusMIRIAM LAUFER; Fiscal Year: 2008..its efficacy both for preventing infection and treating disease and the antifolate combination sulfadoxine-pyrimethamine (SP) took its place...
- Molecular epidemiology of drug resistant malariaMIRIAM LAUFER; Fiscal Year: 2008..provided by applicant): In 1993, Malawi was the first country to switch from choloroquine to sulfadoxine-pyrimethamine (SP) as first line anti-malarial therapy due to unacceptably high failure rates with chloroquine...
- TREATMENT OF CONGENITAL TOXOPLASMOSISRima L McLeod; Fiscal Year: 2010..motor, ocular and audiologic outcome will be determined following treatment with one of two dosages of pyrimethamine plus sulfadiazine during the first year of life...
- NOVEL APICOMPLEXAN METABOLISM AND ORGANELLE TRANSITRima McLeod; Fiscal Year: 2005..gondii, its gene regulation, organelle targeting and better characterization of possible novel antimicrobial agent targets in the shikimate pathway and its branches. ..
- Drug resistant malaria clinical and laboratory studiesSarah Staedke; Fiscal Year: 2005....
- Structural Studies of AIDS-Responsive DrugsVivian Cody; Fiscal Year: 2010..These results will help guide the design of species selective inhibitors. Mutagenesis studies will be carried out to test these possibilitiesin the structure-based correlations to help design novel pjDHFRinhibitors. ..
- HIV & STI Transmission Dynamics along Transport Routes Linking the AmericasKIMBERLY BROUWER; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Single Agents with Designed Combination Chemotherapy PotentialAleem Gangjee; Fiscal Year: 2010..abstract_text> ..
- DRUG RESISTANCE IN MALARIACAROL SIBLEY; Fiscal Year: 2002..When completed their experiments will provide a detailed understanding of the mutations that modify function of the Pf-DHFR and Pf-DHPS enzymes or sensitivity of the enzymes to antifolate drugs. ..
- Plainning malaria training in Zambia Thomas Eisele; Fiscal Year: 2009..Tailoring a sustainable program using appropriate technology and a framework of collaboration in support of PMI activities will greatly increase the likelihood of controlling, and perhaps eventually eliminating, malaria in Zambia. ..
- Antitumor Antimitotics That Reverse Tumor ResistanceAleem Gangjee; Fiscal Year: 2010..The study will also further define the mechanism of action of the novel series and could afford agents for clinical use. ..
- Alpha Folate Receptor Mediated GARFTase Inhibitors as Selective Antitumor AgentsAleem Gangjee; Fiscal Year: 2010....
- Novel, P. jirovecii Specific Antipneumocystis AgentsAleem Gangjee; Fiscal Year: 2009..These agents could be used alone or in combination to treat PCP thus providing novel agents against a new target. ..
- Host Polymorphisms and Uncomplicated MalariaSunil Parikh; Fiscal Year: 2008..Parikh will be able to utilize modern molecular epidemiology techniques to investigate human genetic factors underlying susceptibility to malaria and he will be well equipped for a career in academic research. ..
- Third Generation Antiopportunistic AgentsAleem Gangjee; Fiscal Year: 2003..Screening against tuberculosis (NIAID) and tumor cells in culture (NCI) is also proposed. ..
- NOVEL NONINDUCIBLE THYMIDYLATE SYNTHASE INHIBITORSAleem Gangjee; Fiscal Year: 2004....
- YEAST MODELS OF DRUG-RESISTANT PNEUMOCYSTIS CARINIISteven Meshnick; Fiscal Year: 2004..Ultimately, it is hoped that the results of this study will facilitate the rational use of antipneumocystis drugs. ..
- Bladder Cancer and Urinary Schistosomiasis in GhanaClive Shiff; Fiscal Year: 2004..abstract_text> ..
- MALARIA AND HIV IN PREGNANT WOMEN IN MALAWISteven Meshnick; Fiscal Year: 2005..The results of this study will have important implications for designing public health program s for antenatal care in African and should promote our understanding of the pathogenesis of MTCT. ..
- Routes of Transmission of HIV in Malawian MothersSteven Meshnick; Fiscal Year: 2006..Thus, the results of this project will suggest a comprehensive model of the vector, the route, and the maternal factors associated with HIV vertical transmission. ..
- MOLECULAR EVOLUTION OF P. FALCIPARUM AND P VIVAXAnanias Escalante; Fiscal Year: 2003....
- Congenital and neonatal malaria in MaliAbdoulaye Djimde; Fiscal Year: 2006..research grant ..
- Novel Single, Dual and Multitargeted Inhibitors of RTKsAleem Gangjee; Fiscal Year: 2007..abstract_text> ..
- Antifolates as Antimalarial DrugsCAROL SIBLEY; Fiscal Year: 2007..inhibitors is selected can extend the useful therapeutic life of currently available antifolate drugs like pyrimethamine. More important, these studies have also shown that a third generation antifolate, WR99210, holds great ..
- co-Trimoxazole in Zambian Infants (TZI)CHRISTOPHER GILL; Fiscal Year: 2007..the cessation of TMP-SMZ prophylaxis? 3) Will TMP-SMZ exposure increase rates of resistance to sulfadoxine-pyrimethamine, a leading antimalarial that is cross-tolerant with TMP-SMZ? These questions will be answered by comparing ..
- Burden of Malaria in Pregnancy in IndiaDavidson Hamer; Fiscal Year: 2007..The information generated by the study will also be instrumental in the development of new programs for preventing and mitigating the impact of MIP in India. [unreadable] [unreadable] [unreadable]..
- GENETIC DISSECTION OF TOXOPLASMA GONDIIDavid Roos; Fiscal Year: 2008..and similar mutants isolated in the lab will be screened for differences in sensitivity to combined pyrimethamine/sulfonamide treatment (in addition to sensitivity to pyrimethamine or sulfa alone), and examined for possible ..
- Halogenated Xanthones as Antimalarial AgentsMichael Riscoe; Fiscal Year: 2006..Since heme is an immutable biomolecule, it is difficult to envision any simple mutation that could lead to resistance. ..
- Molecular Epidemiology of Primary CMV InfectionRAVIT BOGER; Fiscal Year: 2008..This application will improve our understanding of acute CMV infection and will open new research directions in vaccine development. . [unreadable] [unreadable] [unreadable] [unreadable]..
- STRUCTURE BASED ANALOGS AS ANTIOPPORTUNISTIC AGENTSAleem Gangjee; Fiscal Year: 2001..The analogues synthesized will also be submitted for screening against tuberculosis (NIAID) parasitic diseases (WHO) and tumor cells in culture (NCI). ..