quinolinic acid

Summary

Summary: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.

Top Publications

  1. ncbi Neurogenesis in the striatum of the quinolinic acid lesion model of Huntington's disease
    A S Tattersfield
    Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Neuroscience 127:319-32. 2004
  2. ncbi Quinolinic acid, the inescapable neurotoxin
    Gilles J Guillemin
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
    FEBS J 279:1356-65. 2012
  3. pmc Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Neuroinflammation 8:94. 2011
  4. ncbi Quinolinic acid reduces the antioxidant defenses in cerebral cortex of young rats
    Guilhian Leipnitz
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal de Rio Grande do Sul, Rua Ramiro Barcelos N 2600 Anexo, CEP 90035 003, Porto Alegre, RS, Brazil
    Int J Dev Neurosci 23:695-701. 2005
  5. pmc Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice
    Lixiang Ma
    Department of Anatomy, Histology and Embryology, Shanghai Medical College, Fudan University, China
    Cell Stem Cell 10:455-64. 2012
  6. ncbi Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum
    Jae K Ryu
    Department of Pharmacology and Therapeutics, Faculty of Medicine, 2176 Health Sciences Mall, The University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Neurobiol Dis 20:550-61. 2005
  7. ncbi Signaling mechanisms downstream of quinolinic acid targeting the cytoskeleton of rat striatal neurons and astrocytes
    Paula Pierozan
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, UFRGS, Porto Alegre, RS, Brazil
    Exp Neurol 233:391-9. 2012
  8. pmc Regulation of quinolinic acid neosynthesis in mouse, rat and human brain by iron and iron chelators in vitro
    Erin K Stachowski
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P O Box 21247, Baltimore, Maryland 21228, USA
    J Neural Transm 119:123-31. 2012
  9. ncbi S-Allylcysteine, a garlic-derived antioxidant, ameliorates quinolinic acid-induced neurotoxicity and oxidative damage in rats
    Francisca Perez-Severiano
    Departamento de Neuroquimica, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, México D F 14269, Mexico
    Neurochem Int 45:1175-83. 2004
  10. ncbi Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
    Rona K Graham
    Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC V5Z 4H4, Canada
    Cell 125:1179-91. 2006

Detail Information

Publications279 found, 100 shown here

  1. ncbi Neurogenesis in the striatum of the quinolinic acid lesion model of Huntington's disease
    A S Tattersfield
    Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Neuroscience 127:319-32. 2004
    ..striatal cell loss on neurogenesis in the subventricular zone (SVZ) of the adult rodent forebrain using the quinolinic acid (QA) lesion rat model of Huntington's disease...
  2. ncbi Quinolinic acid, the inescapable neurotoxin
    Gilles J Guillemin
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
    FEBS J 279:1356-65. 2012
    Over the last two decades, evidence for the involvement of quinolinic acid (QUIN) in neuroinflammatory diseases has been exponentially increasing...
  3. pmc Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Neuroinflammation 8:94. 2011
    ..These peripheral immune processes may be accompanied by microglial activation in subregions of the anterior cingulate cortex where depression-associated alterations of glutamatergic neurotransmission have been described...
  4. ncbi Quinolinic acid reduces the antioxidant defenses in cerebral cortex of young rats
    Guilhian Leipnitz
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal de Rio Grande do Sul, Rua Ramiro Barcelos N 2600 Anexo, CEP 90035 003, Porto Alegre, RS, Brazil
    Int J Dev Neurosci 23:695-701. 2005
    b>Quinolinic acid (QA), the major metabolite of the kynurenine pathway, is found at increased concentrations in brain of patients affected by various common neurodegenerative diseases, including Huntington's disease and Alzheimer's disease...
  5. pmc Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice
    Lixiang Ma
    Department of Anatomy, Histology and Embryology, Shanghai Medical College, Fudan University, China
    Cell Stem Cell 10:455-64. 2012
    ..of these human forebrain GABA neurons and their progenitors, but not spinal GABA cells, into the striatum of quinolinic acid-lesioned mice results in generation of large populations of DARPP32(+) GABA neurons, which project to the ..
  6. ncbi Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum
    Jae K Ryu
    Department of Pharmacology and Therapeutics, Faculty of Medicine, 2176 Health Sciences Mall, The University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Neurobiol Dis 20:550-61. 2005
    ..receptor (PBR) ligand, PK11195, were investigated in the rat striatum following the administration of quinolinic acid (QUIN)...
  7. ncbi Signaling mechanisms downstream of quinolinic acid targeting the cytoskeleton of rat striatal neurons and astrocytes
    Paula Pierozan
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, UFRGS, Porto Alegre, RS, Brazil
    Exp Neurol 233:391-9. 2012
    ..signaling mechanisms involved in the disruption of the cytoskeleton homeostasis were performed in a model of quinolinic acid (QUIN) neurotoxicity in vitro...
  8. pmc Regulation of quinolinic acid neosynthesis in mouse, rat and human brain by iron and iron chelators in vitro
    Erin K Stachowski
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P O Box 21247, Baltimore, Maryland 21228, USA
    J Neural Transm 119:123-31. 2012
    ..tested whether this effect might be related to a functional link between iron and the endogenous excitotoxin quinolinic acid (QUIN), a presumed pathogen in several neurological disorders...
  9. ncbi S-Allylcysteine, a garlic-derived antioxidant, ameliorates quinolinic acid-induced neurotoxicity and oxidative damage in rats
    Francisca Perez-Severiano
    Departamento de Neuroquimica, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, México D F 14269, Mexico
    Neurochem Int 45:1175-83. 2004
    Excitotoxicity elicited by overactivation of N-methyl-D-aspartate receptors is a well-known characteristic of quinolinic acid-induced neurotoxicity...
  10. ncbi Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
    Rona K Graham
    Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC V5Z 4H4, Canada
    Cell 125:1179-91. 2006
    ..mutant htt mice are protected against neurotoxicity induced by multiple stressors including NMDA, quinolinic acid (QA), and staurosporine...
  11. ncbi Time-course correlation of early toxic events in three models of striatal damage: modulation by proteases inhibition
    Verónica Pérez-De La Cruz
    Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, SSA, Mexico DF, Mexico
    Neurochem Int 56:834-42. 2010
    ..to lipids, mitochondrial dysfunction and LDH leakage, all at 1, 3 and 6h) in rat striatal slices exposed to quinolinic acid (QUIN, 100 microM) as an excitotoxic/pro-oxidant model, 3-nitropropionic acid (3-NP, 1mM) as an inhibitor of ..
  12. ncbi A new function for a common fold: the crystal structure of quinolinic acid phosphoribosyltransferase
    J C Eads
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Structure 5:47-58. 1997
    b>Quinolinic acid (QA) is a neurotoxin and has been shown to be present at high levels in the central nervous system of patients with certain diseases, such as AIDS and meningitis...
  13. ncbi Non-steroidal anti-inflammatory agents, tolmetin and sulindac, attenuate oxidative stress in rat brain homogenate and reduce quinolinic acid-induced neurodegeneration in rat hippocampal neurons
    Amichand Dairam
    Faculty of Pharmacy, Rhodes University, P O Box 94, Grahamstown 6140, South Africa
    Metab Brain Dis 21:221-33. 2006
    ..properties of two non-steroidal anti-inflammatory drugs (NSAIDS), tolmetin and sulindac, using quinolinic acid (QA)-induced neurotoxicity as a model...
  14. ncbi Quinolinic acid-iron(ii) complexes: slow autoxidation, but enhanced hydroxyl radical production in the Fenton reaction
    J Platenik
    First Institute of Medical Chemistry and Biochemistry, First Faculty of Medicine, Charles University, Katerinska 32, CZ 12108 Prague 2, Czech Republic
    Free Radic Res 34:445-59. 2001
    ..The present observations suggest that Quin-Fe(II) complexes display significant pro-oxidant characteristics that could have implications for Quin neurotoxicity...
  15. ncbi Selenium-induced antioxidant protection recruits modulation of thioredoxin reductase during excitotoxic/pro-oxidant events in the rat striatum
    Perla D Maldonado
    Laboratorio de Patología Vascular Cerebral, Instituto Nacional de Neurologia y Neurocirugia, Mexico 14269, Mexico
    Neurochem Int 61:195-206. 2012
    ..of our group have demonstrated a protective role of Se in the excitotoxic/pro-oxidant model induced by quinolinic acid (QUIN) in the rat striatum (Santamaría et al...
  16. ncbi Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons
    Nady Braidy
    University of New South Wales, Faculty of Medicine, Sydney, Australia
    FEBS J 277:368-82. 2010
    b>Quinolinic acid (QUIN) excitotoxicity is mediated by elevated intracellular Ca(2+) levels, and nitric oxide-mediated oxidative stress, resulting in DNA damage, poly(ADP-ribose) polymerase (PARP) activation, NAD(+) depletion and cell ..
  17. pmc Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease
    Robert Schwarcz
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, USA
    Prog Neurobiol 90:230-45. 2010
    ..abnormalities in KP metabolism, favoring the formation of two neurotoxic metabolites, 3-hydroxykynurenine and quinolinic acid, over the related neuroprotective agent kynurenic acid...
  18. pmc CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression
    C L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Psychiatry 15:393-403. 2010
    ..2,3-dioxygenase (IDO) catabolizes L-tryptophan (TRP) into L-kynurenine (KYN), which is metabolized to quinolinic acid (QUIN) and kynurenic acid (KA)...
  19. ncbi Migration of neurotrophic factors-secreting mesenchymal stem cells toward a quinolinic acid lesion as viewed by magnetic resonance imaging
    Ofer Sadan
    Department of Neurology, Sackler Faculty of Medicine, Laboratory of Neurosciences, Felsenstein Medical Research Center, Petah Tikva, Israel
    Stem Cells 26:2542-51. 2008
    ..We examined the migratory properties of the cells in the quinolinic acid (QA)-induced striatal lesion model for Huntington's disease...
  20. ncbi Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of L-carnitine
    Daniela Silva-Adaya
    Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico, Mexico
    J Neurochem 105:677-89. 2008
    ..and neurochemical alterations produced in nerve tissue by the excitotoxin and free radical precursor, quinolinic acid (2,3-pyrindin dicarboxylic acid; QUIN), and the mitochondrial toxin, 3-nitropropionic acid (3-NP)...
  21. pmc Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease
    Rona K Graham
    Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    J Neurosci 29:2193-204. 2009
    ..These data highlight the dynamic nature of the mutant htt-mediated excitotoxic phenotype and suggests that therapeutic approaches to HD may need to be altered, depending on the stage and development of the disease...
  22. ncbi Inter-relationships between quinolinic acid, neuroactive kynurenines, neopterin and beta 2-microglobulin in cerebrospinal fluid and serum of HIV-1-infected patients
    M P Heyes
    Section on Analytical Biochemistry, NIMH, NIH, Bethesda, MD 20892
    J Neuroimmunol 40:71-80. 1992
    b>Quinolinic acid (QUIN) is an neurotoxic N-methyl-D-aspartate receptor agonist and an L-tryptophan metabolite of the kynurenine pathway...
  23. ncbi Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease
    L P de Almeida
    Division of Surgical Research and Gene Therapy Center, Lausanne Medical School, Switzerland
    Neurobiol Dis 8:433-46. 2001
    ..injected into the striatum of rats, 3 weeks later the animals were unilaterally lesioned with 180 nmol of quinolinic acid (QA)...
  24. ncbi Synthesis of quinolinic acid by 3-hydroxyanthranilic acid oxygenase in rat brain tissue in vitro
    A C Foster
    J Neurochem 47:23-30. 1986
    ..organs, 3-hydroxyanthranilic acid oxygenase (3HAO), catalyzing the conversion of 3-hydroxyanthranilic acid to quinolinic acid, constitutes a link in the catabolic pathway of tryptophan to NAD...
  25. ncbi In vivo hydroxyl radical formation after quinolinic acid infusion into rat corpus striatum
    A Santamaria
    Departamento de Neuroquimica, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, SSA Av Insurgentes Sur 3877, México D F 14269, Mexico
    Neuroreport 12:2693-6. 2001
    We studied the effect of an acute infusion of quinolinic acid (QUIN) on in vivo hydroxyl radical (.OH) formation in the striatum of awake rats. Using the microdialysis technique, the generation of...
  26. ncbi Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat
    Janine I Rossato
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, 97105 900, RS, Santa Maria, Brazil
    Neurosci Lett 318:137-40. 2002
    ..In this study, we investigated the effect of EBS on quinolinic acid (QA)-induced neurotoxicity...
  27. ncbi Concurrent quantification of quinolinic, picolinic, and nicotinic acids using electron-capture negative-ion gas chromatography-mass spectrometry
    G A Smythe
    Ray Williams Biomedical Mass Spectrometry Facility, UNSW, Wallace Wurth Building, Faculty of Medicine, Sydney, New South Wales, 2052, Australia
    Anal Biochem 301:21-6. 2002
    ..inlet to effectively eliminate sample interference effects in the analysis of trace (femtomolar) levels of quinolinic acid. The method enables rapid and specific concurrent quantification of quinolinic, picolinic, and nicotinic ..
  28. ncbi Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency
    K Saito
    Department of Laboratory Medicine, Gifu University School of Medicine, Gifu 500 8705, Japan
    Am J Physiol Renal Physiol 279:F565-72. 2000
    Marked increases in metabolites of the L-tryptophan-kynurenine pathway, L-kynurenine and quinolinic acid (Quin), were observed in serum and cerebrospinal fluid (CSF) of both the rat and human with renal insufficiency...
  29. ncbi Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 messenger RNA and protein and p53-inducible genes Bax and Gadd-45 in brain areas showing DNA fragmentation
    P E Hughes
    Department of Neurogerontology, Andrus Gerontology Centre, Los Angeles, CA 90089 0191, USA
    Neuroscience 74:1143-60. 1996
    ..Here we report that excitotoxic lesion of rat brain with the N-methyl-D-aspartate receptor agonist, quinolinic acid, induces expression of p53 messenger RNA and protein in brain regions showing delayed DNA fragmentation and ..
  30. ncbi Expression of the kynurenine pathway enzymes in human microglia and macrophages
    Gilles J Guillemin
    Centre for Immunology, St Vincent s Hospital, Sydney, Australia
    Adv Exp Med Biol 527:105-12. 2003
    There is good evidence that the kynurenine pathway (KP) and one of its products, quinolinic acid (QUIN) play a role in the pathogenesis of neurological diseases. Monocytic cells are known to be the major producers of QUIN...
  31. ncbi Peroxynitrite decomposition catalyst, iron metalloporphyrin, reduces quinolinate-induced neurotoxicity in rats
    Dario Santiago-López
    Laboratorio de Aminoácidos Excitadores Departamento de Neuroquímica, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, México D F 14269, Mexico
    Synapse 54:233-8. 2004
  32. ncbi Impact of co administration of selenium and quinolinic acid in the rat's brain
    S Sreekala
    Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram, India
    Brain Res 1281:101-7. 2009
    The effect of two different doses (1 microg and 50 microg Se/100 g body wt) of selenium on quinolinic acid toxicity was investigated in rat's brain...
  33. ncbi Thalidomide inhibition of vascular remodeling and inflammatory reactivity in the quinolinic acid-injected rat striatum
    J K Ryu
    Department of Anesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, 2176 Health Sciences Mall, University of British Columbia, Vancouver, BC, Canada
    Neuroscience 163:601-8. 2009
    ..Intrastriatal injection of quinolinic acid (QUIN) caused time-dependent changes (durations of 6 h, 1 and 7 d post-injection) in vascular remodeling...
  34. ncbi Kynurenine and its metabolites in Alzheimer's disease patients
    E Gulaj
    Department of Geriatrics, Medical University, Bialystok, Poland
    Adv Med Sci 55:204-11. 2010
    ..Alzheimer type dementia and a detailed analysis of correlation between kynurenine (KYN), kynurenic acid (KYNA), 3-hydroxykynurenine (3-HK), anthranilic acid (AA), quinolinic acid (QUIN) and degree of neuropsychological changes in AD.
  35. ncbi The endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress
    Felix Sahm
    Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center DKFZ, Frankfurt, Germany
    Cancer Res 73:3225-34. 2013
    b>Quinolinic acid is a product of tryptophan degradation and may serve as a precursor for NAD(+), an important enzymatic cofactor for enzymes such as the DNA repair protein PARP...
  36. ncbi Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity
    Iván Carmona-Ramírez
    Patología Vascular Cerebral, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico D F, 14269, Mexico
    J Nutr Biochem 24:14-24. 2013
    ..of the antioxidant curcumin to induce transcription factor Nrf2 in a neurodegenerative model induced by quinolinic acid in rats. Animals were administered with curcumin (400 mg/kg, p.o...
  37. pmc Connecting inflammation with glutamate agonism in suicidality
    Sophie Erhardt
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Neuropsychopharmacology 38:743-52. 2013
    ..Inflammation leads to production of quinolinic acid (QUIN) and kynurenic acid (KYNA), an agonist and antagonist of the glutamatergic N-methyl-D-aspartate (NMDA) ..
  38. ncbi Time course of oxidative events in the hippocampus following intracerebroventricular infusion of quinolinic acid in mice
    Marcelo Ganzella
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neurosci Res 55:397-402. 2006
    ..The present study may, therefore, contribute to elucidate the mechanism of the brain dysfunction in patients with several neurological disorders involving elevation of QA in the CSF...
  39. ncbi Similarities and differences in the neuronal death processes activated by 3OH-kynurenine and quinolinic acid
    A Chiarugi
    Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
    J Neurochem 77:1310-8. 2001
    3OH-Kynurenine and quinolinic acid are tryptophan metabolites able to cause, at relatively elevated concentrations, neuronal death in vitro and in vivo...
  40. ncbi Microanatomical evidences for potential of mesenchymal stem cells in amelioration of striatal degeneration
    Edalatmanesh Mohammad Amin
    Institute of Biotechnology, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
    Neurol Res 30:1086-90. 2008
    ..After unilateral lesion in striatum was caused by quinolinic acid (QA), bone marrow derived mesenchymal stem cells, which were isolated and purified from 4-6 weeks old rats, ..
  41. ncbi AAV-BDNF mediated attenuation of quinolinic acid-induced neuropathology and motor function impairment
    A P Kells
    Department of Pharmacology and Clinical Pharmacology, Neural Repair and Neurogenesis Laboratory, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Gene Ther 15:966-77. 2008
    ..of BDNF in the striatum attenuates motor impairment and reduces the extent of striatal damage following quinolinic acid lesioning...
  42. pmc Enhanced neuronal damage by co-administration of quinolinic acid and free radicals, and protection by adenosine A2A receptor antagonists
    W M H Behan
    Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Br J Pharmacol 135:1435-42. 2002
    1. Quinolinic acid may be an important endogenous excitotoxin, but its concentrations in brain are low. We have therefore attempted to determine whether its neurotoxicity can be increased by the simultaneous presence of free radicals. 2...
  43. ncbi The quinolinic acid model of Huntington's disease: locomotor abnormalities
    P R Sanberg
    Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267 0559
    Exp Neurol 105:45-53. 1989
    In contrast to other excitotoxins, such as kainic acid, quinolinic acid (QA) may spare a specific population of striatal neurons that is also spared in Huntington's disease (HD)...
  44. ncbi Differential susceptibility to striatal neurodegeneration induced by quinolinic acid and kainate in inbred, outbred and hybrid mouse strains
    Jessica Pilar McLin
    Department of Neurobiology and Behavior, Reeve Irvine Research Center, 1105 Gillespie Neuroscience Research Facility, University of California at Irvine, CA 92697 4292, USA
    Eur J Neurosci 24:3134-40. 2006
    ..We conducted a survey of the susceptibility of striatal neurons to neurodegeneration induced by quinolinic acid and KA in six inbred, two outbred and two F1 hybrid (resistant*vulnerable) strains...
  45. ncbi Quinolinic acid, alpha-picolinic acid, fusaric acid, and 2,6-pyridinedicarboxylic acid enhance the Fenton reaction in phosphate buffer
    H Iwahashi
    Department of Chemistry, Wakayama Medical College, Japan
    Chem Biol Interact 118:201-15. 1999
    b>Quinolinic acid, alpha-picolinic acid, fusaric acid, and 2,6-pyridinedicarboxylic acid enhanced the Fenton reaction in phosphate buffer, respectively...
  46. ncbi Protective effects of the antioxidant selenium on quinolinic acid-induced neurotoxicity in rats: in vitro and in vivo studies
    Abel Santamaria
    Departamento de Neuroquímica and Neuromorfología Celular, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico City, Mexico
    J Neurochem 86:479-88. 2003
    b>Quinolinic acid (QUIN), a well known excitotoxin that produces a pharmacological model of Huntington's disease in rats and primates, has been shown to evoke degenerative events in nerve tissue via NMDA receptor (NMDAr) overactivation and ..
  47. pmc Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid
    M P Heyes
    Section on Analytical Biochemistry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892
    Biochem J 283:633-5. 1992
    Substantial increases in the concentrations of the excitotoxin and N-methyl-D-aspartate-receptor agonist quinolinic acid (QUIN) occur in human patients and non-human primates with inflammatory diseases...
  48. ncbi Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease
    Paolo Guidetti
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neurobiol Dis 17:455-61. 2004
    ..These results support a possible involvement of 3-HK and QUIN in the early phases of HD pathophysiology and indicate novel therapeutic strategies against the disease...
  49. pmc Striatal progenitors derived from human ES cells mature into DARPP32 neurons in vitro and in quinolinic acid-lesioned rats
    Laetitia Aubry
    Institut National de la Santé et de la Recherche Médicale Université d Evry Val d Essonne Unité Mixte de Recherche 861, Institute for Stem Cell Therapy and Exploration of Monogenic Diseases, Association Francaise contre les Myopathies, 91030 Evry, France
    Proc Natl Acad Sci U S A 105:16707-12. 2008
    ..Long-term proliferation of human neural progenitors leads, however, to xenograft overgrowth in the rat brain, suggesting that the path to the clinic requires a way to switch them off after grafting...
  50. ncbi Chronic quinolinic acid lesions in rats closely resemble Huntington's disease
    M F Beal
    Neurochemistry and Experimental Neuropathology Laboratories, Massachusetts General Hospital, Boston 02114
    J Neurosci 11:1649-59. 1991
    ..At 6 months and 1 yr, lesions with the NMDA receptor agonist quinolinic acid (QA) resulted in significant increases (up to twofold) in concentrations of somatostatin and neuropeptide Y ..
  51. ncbi Acute intrastriatal administration of quinolinic acid provokes hyperphosphorylation of cytoskeletal intermediate filament proteins in astrocytes and neurons of rats
    Paula Pierozan
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, UFRGS, Porto Alegre, RS, Brasil
    Exp Neurol 224:188-96. 2010
    In the present study we investigated the effect of in vivo intrastriatal injection of quinolinic acid (QA) on cytoskeletal proteins in astrocytes and neurons of young rats at early stage (30 min) after infusion. QA (150 nmoles/0...
  52. ncbi Quinolinic acid upregulates chemokine production and chemokine receptor expression in astrocytes
    Gilles J Guillemin
    Centre for Immunology, St Vincent s Hospital, Sydney, Australia
    Glia 41:371-81. 2003
    Within the brain, quinolinic acid (QUIN) is an important neurotoxin, especially in AIDS dementia complex (ADC). Its production by monocytic lineage cells is increased in the context of inflammation...
  53. ncbi Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities
    Robert Schwarcz
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, USA
    J Pharmacol Exp Ther 303:1-10. 2002
    ..the free radical generator 3-hydroxykynurenine, the excitotoxic N-methyl-D-aspartate (NMDA) receptor agonist quinolinic acid, and the NMDA and alpha7 nicotinic acetylcholine receptor antagonist kynurenic acid...
  54. ncbi Beneficial effects of rolipram in a quinolinic acid model of striatal excitotoxicity
    Zena DeMarch
    Laboratory of Neuroanatomy, Santa Lucia Foundation IRCCS at the European Center for Brain Research, Via del Fosso Fiorano 64, 00143 Rome, Italy
    Neurobiol Dis 25:266-73. 2007
    ..Such decrease was also described by our group in the quinolinic acid lesion model of striatal excitotoxicity...
  55. ncbi Licofelone attenuates quinolinic acid induced Huntington like symptoms: possible behavioral, biochemical and cellular alterations
    Harikesh Kalonia
    Pharmacology Division, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh 160014, India
    Prog Neuropsychopharmacol Biol Psychiatry 35:607-15. 2011
    ..has been designed to explore the neuroprotective potential of licofelone (dual COX-2/5-LOX inhibitor) against quinolinic acid induced Huntington like symptom in rats...
  56. ncbi Correlations between behavioural and oxidative parameters in a rat quinolinic acid model of Huntington's disease: protective effect of melatonin
    Ethel Antunes Wilhelm
    Universidade Regional Integrada do Alto Uruguai e das Missões Campus Santiago, Santiago, RS, Brazil
    Eur J Pharmacol 701:65-72. 2013
    The present study was designed to examine the correlations between behavioural and oxidative parameters in a quinolinic acid model of Huntington's disease in rats...
  57. ncbi Intracerebroventricular administration of inosine is anticonvulsant against quinolinic acid-induced seizures in mice: an effect independent of benzodiazepine and adenosine receptors
    Marcelo Ganzella
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Pharmacol Biochem Behav 100:271-4. 2011
    Inosine (INO) has an anticonvulsant effect against seizures induced by antagonists of GABAergic system. Quinolinic acid (QA) is an agonist NMDA receptors implicated in the neurobiology of seizures...
  58. ncbi GFAP knockout mice have increased levels of GDNF that protect striatal neurons from metabolic and excitotoxic insults
    Rose Hanbury
    Research Center for Brain Repair and Department of Neurological Sciences, Rush Presbyterian Medical Center, Chicago, Illinois 60612, USA
    J Comp Neurol 461:307-16. 2003
    ..acid (3-NP), an irreversible inhibitor of mitochondrial complex II activity or the excitotoxin quinolinic acid (QA)...
  59. ncbi Relationship of neurologic status in macaques infected with the simian immunodeficiency virus to cerebrospinal fluid quinolinic acid and kynurenic acid
    M P Heyes
    Section of Analytical Biochemistry, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892
    Brain Res 570:237-50. 1992
    Increased concentrations of the excitotoxin quinolinic acid (QUIN) have been implicated in the neurologic deficits and brain atrophy that may accompany infection with the human immunodeficiency virus type-1...
  60. pmc Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types
    M P Heyes
    Laboratory of Neurotoxicology, NIMH, Bethesda, MD 20892 1262, USA
    Biochem J 326:351-6. 1997
    Substantial increases in the tryptophan-kynurenine pathway metabolites, l-kynurenine and the neurotoxin quinolinic acid, occur in human brain, blood and systemic tissues during immune activation...
  61. ncbi Quinolinic acid protects rat cerebellar granule cells from glutamate-induced apoptosis
    Y Sei
    Department of Anesthesiology, The Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Neurosci Lett 241:180-4. 1998
    The effects of quinolinic acid (QUIN) on glutamate-induced excitotoxicity were examined in primary cultures of rat cerebellar granule neurons. Exposing these neurons to QUIN (< or =2...
  62. ncbi Brain-derived neurotrophic factor prevents changes in Bcl-2 family members and caspase-3 activation induced by excitotoxicity in the striatum
    Esther Pérez-Navarro
    Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Casanova 143, E 08036 Barcelona, Spain
    J Neurochem 92:678-91. 2005
    ..These results provide a possible mechanism to explain the anti-apoptotic effect of BDNF against to excitotoxicity in the striatum through the regulation of Bcl-2 family members, which is probably mediated by Akt activation...
  63. ncbi Neuroprotective effects of the mGlu5R antagonist MPEP towards quinolinic acid-induced striatal toxicity: involvement of pre- and post-synaptic mechanisms and lack of direct NMDA blocking activity
    Patrizia Popoli
    Department of Pharmacology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Neurochem 89:1479-89. 2004
    ..the metabotropic glutamate receptor 5 (mGlu5R) antagonist 2-Methyl-6-(phenylethynyl)-pyridine (MPEP) towards quinolinic acid (QA)-induced striatal excitoxicity. Intrastriatal MPEP (5 nmol/0...
  64. ncbi Phosphodiesterase 10 inhibition reduces striatal excitotoxicity in the quinolinic acid model of Huntington's disease
    Carmela Giampà
    Laboratory of Neuroanatomy, Santa Lucia Foundation IRCCS Hospital, Rome, Italy
    Neurobiol Dis 34:450-6. 2009
    ..Rats were surgically administered with quinolinic acid into striatum and subsequently treated with TP10 daily for two or eight weeks...
  65. ncbi Quinolinic acid induced neurodegeneration in the striatum: a combined in vivo and in vitro analysis of receptor changes and microglia activation
    R M Moresco
    IBFM CNR, University of Milan Bicocca, Nuclear Medicine Department, San Raffaele Scientific Institute, Milano, Italy
    Eur J Nucl Med Mol Imaging 35:704-15. 2008
    ..pharmacological models of HD is produced by local injection in the rat brain striatum of the excitotoxin quinolinic acid (QA), which produces many of the distinctive features of this human neurodegenerative disorder...
  66. pmc Roles for cationic residues at the quinolinic acid binding site of quinolinate phosphoribosyltransferase
    Zainab Bello
    Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, Pennsylvania 19140, USA
    Biochemistry 49:1388-95. 2010
    b>Quinolinic acid phosphoribosyltransferase (QAPRTase, EC 2.4.2.19) forms nicotinate mononucleotide (NAMN) from quinolinic acid (QA) and 5-phosphoribosyl 1-pyrophosphate (PRPP). Previously determined crystal structures of QAPRTase...
  67. ncbi Systemic endotoxin increases L-tryptophan, 5-hydroxyindoleacetic acid, 3-hydroxykynurenine and quinolinic acid content of mouse cerebral cortex
    M P Heyes
    Section on Analytical Biochemistry, National Institute of Mental Health, Bethesda, MD 20892
    Brain Res 491:173-9. 1989
    ..L-tryptophan, 42% and 39%; 5-hydroxyindoleacetic acid, 38% and 67%; 3-hydroxykynurenine, 235% and 381%; and quinolinic acid, 76% and 306%...
  68. ncbi Non-steroidal anti-inflammatory agents, tolmetin and sulindac attenuate quinolinic acid (QA)-induced oxidative stress in primary hippocampal neurons and reduce QA-induced spatial reference memory deficits in male Wistar rats
    Amichand Dairam
    Rhodes University, PO Box 94, Faculty of Pharmacy, Grahamstown, 6140, South Africa
    Life Sci 80:1431-8. 2007
    ..the present study, the possible neuroprotective properties of tolmetin and sulindac were investigated using quinolinic acid (QA)-induced neurotoxicity as well as behavioral studies...
  69. ncbi Cytoplasmic calcium mediates oxidative damage in an excitotoxic /energetic deficit synergic model in rats
    Verónica Pérez-De La Cruz
    Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, S S A, Mexico DF 14269, Mexico
    Eur J Neurosci 27:1075-85. 2008
    ..Our results suggest that the lipid peroxidation induced in synaptosomal fractions by quinolinate plus 3-nitropropionate is largely dependent on the cytoplasmic concentrations of calcium...
  70. ncbi Nigrostriatal pathway modulates striatum vulnerability to quinolinic acid
    A Buisson
    Laboratoire de Pharmacologie, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Rene Descartes, Paris, France
    Neurosci Lett 131:257-9. 1991
    This study evaluates the modulation of striatum vulnerability to quinolinic acid (QA) by the nitrostriatal projection...
  71. pmc Microglia/macrophage-derived inflammatory mediators galectin-3 and quinolinic acid are elevated in cerebrospinal fluid from newborn infants after birth asphyxia
    Karin Savman
    Perinatal Center, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, 416 85 Goteborg, Sweden Department of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, 416 85 Goteborg, Sweden Perinatal Center, The Queen Silvia Children s Hospital, 416 85 Goteborg, Sweden
    Transl Stroke Res 4:228-35. 2013
    ..Both galectin-3 and MMP-9 contribute to brain injury in animal models for neonatal HI. Quinolinic acid (QUIN) is a neurotoxic N-methyl-D-aspartate (NMDA) receptor agonist also produced by activated microglia/..
  72. pmc A pro-convulsive carbamazepine metabolite: quinolinic acid in drug resistant epileptic human brain
    Chaitali Ghosh
    Cerebrovascular Research, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Neurobiol Dis 46:692-700. 2012
    ..fractions were subsequently analyzed by mass spectrometry to reveal micromolar concentrations of quinolinic acid (QA)...
  73. ncbi Copper blocks quinolinic acid neurotoxicity in rats: contribution of antioxidant systems
    Abel Santamaria
    Laboratorio de Aminoácidos Excitadores Departamento de Neuroquímica, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico, D F, Mexico
    Free Radic Biol Med 35:418-27. 2003
    Reactive oxygen species and oxidative stress are involved in quinolinic acid (QUIN)-induced neurotoxicity...
  74. ncbi In vivo quinolinic acid increases synaptosomal glutamate release in rats: reversal by guanosine
    Rejane G Tavares
    Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neurochem Res 30:439-44. 2005
    ..b>Quinolinic acid (QA) is a glutamatergic agent that induces seizures and is involved in the etiology of epilepsy...
  75. ncbi Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome
    J C Bensadoun
    Division of Surgical Research and Gene Therapy Center, Lausanne Medical School, Pavillon 4, CHUV, 1011 Lausanne, Switzerland
    Eur J Neurosci 14:1753-61. 2001
    ..Therefore, we investigated the neuroprotective effect of these two molecules in the quinolinic acid model of Huntington's disease...
  76. ncbi Quinolinic acid-induced inflammation in the striatum does not impair the survival of neural allografts in the rat
    W M Duan
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Department of Physiology and Neuroscience, University of Lund, S olvegatan 17, S 223 62 Lund, Sweden
    Eur J Neurosci 10:2595-606. 1998
    ..The target striatum was either intact or had received a local injection of quinolinic acid 9 days earlier, in order to induce a marked inflammation...
  77. ncbi Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease
    Krystyna Pawlak
    Department of Monitored Pharmacotherapy, Medical University, Bialystok, Poland
    Atherosclerosis 204:561-6. 2009
    ..We determined the plasma concentrations of kynurenine (KYN), kynurenic acid (KYNA) and quinolinic acid (QA); three distinct SOX markers: Cu/Zn superoxide dismutase (Cu/Zn SOD), total peroxide and malondialdehyde (..
  78. ncbi Increase of adenine nucleotide hydrolysis in rat hippocampal slices after seizures induced by quinolinic acid
    Rafael Nicolaidis
    Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Neurochem Res 30:385-90. 2005
    b>Quinolinic acid (QUIN), an endogenous convulsant compound, overstimulates the glutamatergic system stimulating N-methyl-D-aspartate receptors, enhancing glutamate release and inhibiting glutamate uptake...
  79. ncbi Differential sensitivity of neuropeptide Y, somatostatin and NADPH-diaphorase containing neurons in rat cortex and striatum to quinolinic acid
    R J Boegman
    Department of Pharmacology and Toxicology, Queen s University, Kingston, Ont, Canada
    Brain Res 445:358-62. 1988
    The tryptophan metabolite quinolinic acid (QUIN) was injected unilaterally into rat cerebral cortex or striatum in order to determine whether the neurotoxin would destroy neuropeptide Y (NPY)- and somatostatin (SS)-immunoreactive, and ..
  80. ncbi Glucocorticoid enhances the neurotoxic actions of quinolinic acid in the striatum in a cell-specific manner
    L Y Ngai
    Department of Anatomy and Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK
    J Neuroendocrinol 17:424-34. 2005
    This study demonstrates that corticosterone can exacerbate the damaging effects of infused quinolinic acid (QA) on the dorsal striatum...
  81. ncbi Protective effect of rofecoxib and nimesulide against intra-striatal quinolinic acid-induced behavioral, oxidative stress and mitochondrial dysfunctions in rats
    Harikesh Kalonia
    Pharmacology Division, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh, India
    Neurotoxicology 31:195-203. 2010
    ..b>Quinolinic acid is an endogenous excitotoxin that causes neurotoxicity in diverse areas of the brain and produces motor ..
  82. ncbi Behavioral and anatomical effects of quinolinic acid in the striatum of the hemiparkinsonian rat
    M E Olds
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Synapse 55:26-36. 2005
    ..Group I was unilaterally sham-lesioned in medial, central, and lateral striatum. Group II was injected quinolinic acid (QA) 20 nM in medial, central, and lateral striatum. Group III was injected QA 60 nM in central striatum...
  83. ncbi Protective effect of montelukast against quinolinic acid/malonic acid induced neurotoxicity: possible behavioral, biochemical, mitochondrial and tumor necrosis factor-α level alterations in rats
    H Kalonia
    Pharmacology Division, University Institute of Pharmaceutical Sciences, University Grants Commission Centre of Advanced Study, Panjab University, Chandigarh 160014, India
    Neuroscience 171:284-99. 2010
    ..to explore the protective effect of montelukast (leukotriene receptor antagonist) against intrastriatal quinolinic acid (QA; 300 nmol) and malonic acid (MA; 6 μmol) induced Huntington's like symptoms in rats...
  84. ncbi Prolonged survival and expression of neural markers by bone marrow-derived stem cells transplanted into brain lesions
    Esteban Alberti
    Department of Neurobiology, International Center of Neurological Restoration, CIREN, Havana, Cuba
    Med Sci Monit 15:BR47-54. 2009
    ..Bone marrow-derived stem cell transplantation is a potentially viable therapeutic option for the treatment of neurodegenerative disease...
  85. ncbi Melatonin neutralizes neurotoxicity induced by quinolinic acid in brain tissue culture
    Ignacio Vega-Naredo
    Departamento de Morfologia y Biologia Celular, Facultad de Medicina, Universidad de Oviedo, Oviedo, Asturias, Spain
    J Pineal Res 39:266-75. 2005
    b>Quinolinic acid is a well-known excitotoxin that induces oxidative stress and damage...
  86. ncbi Adenoviral gene delivery of pigment epithelium-derived factor protects striatal neurons from quinolinic acid-induced excitotoxicity
    Tomomi Sanagi
    Kitasato Institute for Life Sciences, Kitasato University, Minato ku, Tokyo, Japan
    J Neuropathol Exp Neurol 69:224-33. 2010
    ..We examined the effects of adenovirus-mediated gene transfer of PEDF on quinolinic acid (QA)-induced neurotoxicity in rats. Adenoviral vector containing the human PEDF gene (Ad...
  87. ncbi Comparative neuroprotective profile of statins in quinolinic acid induced neurotoxicity in rats
    Harikesh Kalonia
    Pharmacology Division, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh 160014, India
    Behav Brain Res 216:220-8. 2011
    ..Here, we sought to determine neuroprotective effect of statins in quinolinic acid induced neurotoxicity in rats...
  88. ncbi Suppressing inflammatory cascade by cyclo-oxygenase inhibitors attenuates quinolinic acid induced Huntington's disease-like alterations in rats
    Harikesh Kalonia
    Pharmacology Division, University Institute of Pharmaceutical Sciences, UGC Centre for Advanced Studies, Panjab University, Chandigarh, India
    Life Sci 88:784-91. 2011
    The aim of this study was to investigate the protective effects of cyclo-oxygenase inhibitors against quinolinic acid (QA) induced Huntington's disease-like alterations in rats.
  89. ncbi On the early toxic effect of quinolinic acid: involvement of RAGE
    Elvis Cuevas
    Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurologia y Neurocirugia, Manuel Velasco Suarez, S S A Insurgentes Sur 3877, Mexico, D F 14269, Mexico
    Neurosci Lett 474:74-8. 2010
    b>Quinolinic acid (QUIN)-induced toxicity is characterized by N-methyl-d-aspartate receptors over-activation, excitotoxicity and oxidative damage...
  90. ncbi Comparison of transplant efficiency between spontaneously derived and noggin-primed human embryonic stem cell neural precursors in the quinolinic acid rat model of Huntington's disease
    Elena M Vazey
    Department of Pharmacology and Clinical Pharmacology, FMHS, University of Auckland, Auckland, New Zealand
    Cell Transplant 19:1055-62. 2010
    ..characteristics of spontaneously derived and noggin-primed hNP following transplantation into the quinolinic acid (QA) rat model of HD...
  91. ncbi In vitro effect of quinolinic acid on energy metabolism in brain of young rats
    Patrícia Fernanda Schuck
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neurosci Res 57:277-88. 2007
    b>Quinolinic acid (QA) is found at increased concentrations in brain of patients affected by various common neurodegenerative disorders, including Huntington's and Alzheimer's diseases...
  92. ncbi Quinolinic acid up-regulates chemokine production and chemokine receptor expression in astrocytes
    Juliana Croitoru-Lamoury
    Centre for Immunology, St Vincent s Hospital, Sydney, Australia
    Adv Exp Med Biol 527:37-45. 2003
    Within the brain, quinolinic acid (QUIN) is an important neurotoxin, especially in AIDS dementia complex (ADC). Its production by monocytic lineage cells is increased in the context of inflammation...
  93. ncbi Effects of caffeic acid, rofecoxib, and their combination against quinolinic acid-induced behavioral alterations and disruption in glutathione redox status
    Harikesh Kalonia
    Pharmacology Division, University Institute of Pharmaceutical Sciences, University Grants Commission, Centre of Advanced Study, Panjab University, Chandigarh, India
    Neurosci Bull 25:343-52. 2009
    ..The neuroprotective roles of cyclooxygenase (COX) and lipooxygenase (LOX) inhibitors have been well documented. Quinolinic acid (QA) is a well-known excitotoxic agent that could induce behavioral, morphological and biochemical ..
  94. ncbi Quinolinic acid accumulation during neuroinflammation. Does it imply excitotoxicity?
    T P Obrenovitch
    School of Pharmacy, University of Bradford, Bradford BD7 1DP, U K
    Ann N Y Acad Sci 939:1-10. 2001
    It is often proposed that quinolinic acid (QUIN) contributes to the pathophysiology of neuroinflammation because this kynurenine pathway metabolite is a selective agonist of N-methyl-D-aspartate (NMDA) receptors, and both its brain ..
  95. ncbi Effects of systemic and central nervous system localized inflammation on the contributions of metabolic precursors to the L-kynurenine and quinolinic acid pools in brain
    Tomoyuki Kita
    Laboratory of Neurotoxicology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurochem 82:258-68. 2002
    L-Kynurenine and quinolinic acid are neuroactive L-tryptophan-kynurenine pathway metabolites of potential importance in pathogenesis and treatment of neurologic disease...
  96. ncbi Quinolinic acid is a potent lipid peroxidant in rat brain homogenates
    C Rios
    Departamento de Neuroquimica, Instituto Nacional de Neurologia y Neurocirugia Dr Manuel Velasco Suarez, Mexico, D F
    Neurochem Res 16:1139-43. 1991
    In this study, we describe the lipoperoxidative effect of quinolinic acid (QUIN) in vitro...
  97. ncbi Quinolinic acid enhances permeability of rat brain microvessels to plasma albumin
    F St'astný
    Department of Molecular Neurobiology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Brain Res Bull 53:415-20. 2000
    Several studies have established that increased cerebrospinal fluid (CSF) levels of quinolinic acid (QUIN), a macrophage/microglia-derived excitotoxin with N-methyl-D-aspartate (NMDA)-receptor affinity, may reflect abnormal blood-brain ..
  98. ncbi Effects of aging on quinolinic acid lesions in rat striatum
    S F Finn
    Neurochemistry Laboratory, Massachusetts General Hospital, Boston
    Brain Res 562:276-80. 1991
    ..In the present study we examined the susceptibility of rats to quinolinic acid striatal lesions at 1, 4 and 20 months of age, and susceptibility to N-methyl-D-aspartate (NMDA) at 1 and 4 ..
  99. ncbi Is quinolinic acid an endogenous excitotoxin in alcohol withdrawal?
    P F Morgan
    Laboratory of Clinical Studies, National Institute of Alcohol Abuse and Alcoholism, Bethesda, MD 20892
    Med Hypotheses 36:118-21. 1991
    ..This is likely to result in elevated brain levels of the potent excitotoxin quinolinic acid (quinolinate) since levels of this tryptophan metabolite can be elevated considerably by tryptophan loading...
  100. ncbi Guanosine and GMP prevent seizures induced by quinolinic acid in mice
    A P Schmidt
    Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, Avenida Ramiro Barcelos, 2600 Anexo, CEP 90035 003, Porto Alegre, Brazil
    Brain Res 864:40-3. 2000
    ..p. guanosine and GMP against seizures induced by the glutamate agonist quinolinic acid (QA) or the GABA(A) antagonist picrotoxin in mice. Animals were pretreated with an i.p...
  101. ncbi Quinolinic acid stimulates somatostatin gene expression in cultured rat cortical neurons
    S C Patel
    Fraser Laboratories, Department of Medicine, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada
    J Neurochem 56:1286-91. 1991
    ..Since HD brain is capable of producing excessive quantities of the excitotoxin quinolinic acid (Quin), an N-methyl-D-aspartate (NMDA) receptor agonist, and since experimental Quin lesions show neuronal ..

Research Grants51

  1. Neuroimaging abnormalities in major depressive disorder: effect of inflammation
    Jonathan Savitz; Fiscal Year: 2013
    ..the synthesis of kynurenine (KYN) and neurotoxic KYN metabolites, such as 3-hydroxykynurenine (3HK), and quinolinic acid (QUIN)...
  2. Phenotyping Major Depression with Increased Inflammation
    Andrew H Miller; Fiscal Year: 2013
    ..cerebrospinal fluid (CSF) concentrations of metabolites of indoleamine 2,3 dioxygenase including kynurenine, quinolinic acid and kynurenic acid, which has been shown to reduce dopamine release in the basal ganglia...
  3. Biobehavioral Role of Brain Kynurenine Metabolism in Mental Illness
    JASON C O'CONNOR; Fiscal Year: 2013
    ..and 3-hydroxyanthranilic acid en route to generating the ionotropic glutamate receptor agonist, quinolinic acid. Conversely, endothelial cells and astrocytes produce kynurenic acid, which is a glutamate and 17-nicotinic ..
  4. MR SPECTROSCOPY TO REVEAL CNS MECHANISMS OF CYTOKINE-INDUCED BEHAVIORAL CHANGE
    Ebrahim Haroon; Fiscal Year: 2013
    ..of CNS inflammatory responses and cytokine-induced increases in excitotoxic kynurenine metabolites, including quinolinic acid. To test these hypotheses, 50 adult patients with hepatitis C will be studied pre- and post-IFN-alpha...
  5. Molecular control of neurogenesis in the adult subventricular zone
    Masato Nakafuku; Fiscal Year: 2013
    ..We will examine if Gsx1+ and Gsx2+ progenitors participate in ectopic neurogenesis following quinolinic acid (QA)-induced excitotoxic injury in the striatum...
  6. Bupropion for Depression in ESRD Patients on Hemodialysis
    Pedro L Delgado; Fiscal Year: 2013
    ..total tryptophan (TRP), and increased levels of free TRP and the TRP catabolites kynurenine (KYN) and quinolinic acid. Increased inflammatory cytokines, decreased TRP, and increased KYN and quinolinic acid are associated with ..
  7. IDO Regulation in the SIV Model of HIV CNS Disease
    M Christine Zink; Fiscal Year: 2013
    ..The Kyn metabolite quinolinic acid leads to neurodegeneration by promoting NMDA (N-methyl-D-aspartic acid) receptor-mediated excitotoxicity...
  8. Identifying Epileptogenic Tubers in TSC
    Harry Chugani; Fiscal Year: 2013
    ..g., quinolinic acid. This observation provides important clues to epileptogenesis and, therefore, a better understanding of this ..
  9. The Role of Microglia and the Kynurenine Pathway in Huntington's Disease
    Paul J Muchowski; Fiscal Year: 2012
    ..The brain levels of two neurotoxic metabolites in the KP, quinolinic acid (QUIN) and 3-hydroxykynurenine (3-HK), are increased in the striatum and neocortex in early grade HD;similar ..
  10. Mechanisms and novel therapy in intrauterine inflammation induced brain injury
    Sujatha Kannan; Fiscal Year: 2013
    ..kynurenine pathway, in order to decrease the formation of the neurotoxic metabolites 3-hydroxykynurenine and quinolinic acid by inhibiting the enzyme kynurenine mono- oxygenase (KMO)...
  11. The Neuroimmunology of Anhedonia
    Vilma Gabbay; Fiscal Year: 2013
    ..Anhedonia will be measured quantitatively. Blood samples for cytokines, KP metabolites (including quinolinic acid and 3-hydroxykynurenine), kynurenine 3-monooxygenase enzyme activity (initiates the KP neurotoxic branch), ..
  12. Endogenous CNTF receptors and adult, in vivo neurogenesis
    ALEXANDER JOHN MACLENNAN; Fiscal Year: 2013
    ..that suggest that endogenous CNTF receptor signaling regulates neurogenesis in the adult striatum following quinolinic acid (QA)-induced neurotoxic injury, possibly through insult-induced increases in CNTF and CNTF receptor dependent ..
  13. DEVELOPMENTAL MODELS OF GATING DEFICITS IN SCHIZOPHRENIA
    Mark A Geyer; Fiscal Year: 2010
    ..Hence, Aim 1 studies will assess the contribution of KYNA and its metabolites 3-hydroxykynurenine (3-HK) and quinolinic acid (QUIN) to isolation rearing-induced PPI deficits in rats...
  14. Neuroprotective Effects of Estrogen in Serotonin Neurons
    Jessica Henderson; Fiscal Year: 2007
    ..expression in the dorsal raphe nuclei, and investigate the effect of estrogen treatment on kynurenic acid/ quinolinic acid ratios in serotonin neurons of the dorsal raphe nucleus, serum, CSF and urine...
  15. NEUROPATHOLOGY AND PATHOGENESIS OF HUNTINGTON' DISEASE
    Anton Reiner; Fiscal Year: 2004
    ..e. HD pathology can be reproduced by 3-NP and by quinolinic acid administration f. Neurons that die are rich in cortical input. g...
  16. BEHAVIORAL AND NEURONAL EFFECTS OF RETROVIRAL INFECTION
    Ian Paul; Fiscal Year: 1999
    ..humans, LP-BM5 infection of mice profoundly increases CNS levels of the glutamatergic neuronal excitotoxin, quinolinic acid. Moreover, LP-BM5 infection results in alterations in ligand binding to the N-methyl-D-aspartate (NMDA) ..
  17. NEURAL TRANSPLANTS, BEHAVIOR & HUNTINGTON'S MODEL
    Paul Sanberg; Fiscal Year: 1990
    ..However, a novel excitotoxin, quinolinic acid (QA) has recently been reported to be a more accurate biochemical model of HD...
  18. CELLULAR FREE RADICAL TOXICITY MECHANISMS
    OLEN BROWN; Fiscal Year: 1999
    ..b>Quinolinic acid (QA), a metabolite of the brain kynurenine pathway from tryptophan, is the most potent endogenous excitatory ..
  19. NEURONAL ELECTROPHYSIOLOGY IN HIV DEMENTIA
    HOWARD GENDELMAN; Fiscal Year: 2001
    ..cytokines, platelet activating factor, free radicals and excitatory amino acids (including cysteine and quinolinic acid). The specific mechanism(s) responsible for neuronal loss have not as yet been identified...
  20. EARLY DETECTION OF CNS INVOLVEMENT IN HIV
    Robert Lenkinski; Fiscal Year: 1999
    ..CSF: quantitative HIV RNA levels (a measure of viral burden) and concentrations of beta-2-microglobulin and quinolinic acid (measures of immune activation) in this newly enrolled group...
  21. ADVANCED MR SPECTROSCOPY OF SIV BRAIN INJURY
    Ramon Gonzalez; Fiscal Year: 2001
    ..In collaboration with M. Heyes NIMH, the levels of quinolinic acid will be measured as well...
  22. NGF GRAFTS AND HUNTINGTONS DISEASE
    Jeffrey Kordower; Fiscal Year: 2000
    DESCRIPTION: Intrastriatal injections of excitotoxins such as quinolinic acid (QA) result in a selective loss of striatal neurons mimicking the selective vulnerability of neuronal populations seen in Huntington's disease...
  23. METHODS FOR KYNURENINE SYSTEM IN HUNTINGTON'S DISEASE
    Wayne Matson; Fiscal Year: 1990
    ..These were consistent with the quinolinic acid hypothesis of neuronal degeneration...
  24. Imaging Serotonergic Transmission in HIV Depression
    Martin Pomper; Fiscal Year: 2006
    ..pathway, an alternative route of tryptophan metabolism that effectively depletes CNS 5-HT levels and produces quinolinic acid, an excitotoxin, that may damage 5-HT neurons...
  25. HUNTINGTON DISEASE AND QUINOLINATE--STRIATAL CELL TYPES
    Roger Albin; Fiscal Year: 1992
    ..the relative loss or preservation of subpopulations of striatal neurons in Huntington's disease (HD) and the quinolinic acid (QA) model of HD...
  26. Development of 4-Chlorokynurenine to Treat Epilepsy
    RALPH SNODGRASS; Fiscal Year: 2004
    ..Furthermore, 4-CI-KYN forms a second metabolite, which blocks the synthesis of the proconvulsant quinolinic acid in brain. These unique properties make 4-CI-KYN a highly innovative candidate for the treatment of epilepsy...
  27. Orotate Phosphoribosyltransferase-Mechanism
    Charles Grubmeyer; Fiscal Year: 2005
    ..A second target of the project is the Type II quinolinic acid PRTase, whose general mechanism is poorly understood...
  28. Preclinical Development of 4-CI-KYN to Treat Epilepsy
    RALPH SNODGRASS; Fiscal Year: 2007
    ..Furthermore, 4-C1-KYN forms a second metabolite, which blocks the synthesis of the proconvulsant quinolinic acid in brain. These unique properties make 4-C1-KYN a highly innovative candidate for the treatment of epilepsy...
  29. GENE EXPRESSION IN HIV ASSOCIATED DEMENTIA BRAIN
    Paul Shapshak; Fiscal Year: 2004
    ..genes, nitric oxide synthases, cell surface markers, adhesion molecules, and toxic glutamic, arachidonic, and quinolinic acid pathways...
  30. NEUROTOXIC AMINO ACID MECHANISMS IN VIVO AND IN VITRO
    Robert Schwarcz; Fiscal Year: 1999
    ..it was assumed that hyperphysiological concentrations of endogenous EAA receptor ligands such as glutamate or quinolinic acid (QUIN) are necessary for nerve cell death to occur ("direct excitotoxicity")...
  31. ANTIBODY BASED ASSAY FOR QUINOLICIC ACID
    BRIAN CRAINE; Fiscal Year: 1991
    ..Adapted from the applicant's abstract) The goal of this Phase I project is to prepare antibodies against quinolinic acid and perform some initial experiments to determine the specificity of an assay for quinolinic acid based on ..
  32. Mechanistic enzymology of quinolinic acid biosynthesis
    Tadhg Begley; Fiscal Year: 2008
    ..Surprisingly, the biosynthesis of the key catalytic part of this cofactor, the quinolinic acid derived pyridine ring, is still poorly understood...
  33. KYNURENINES, GLIA AND EPILEPSY
    Robert Schwarcz; Fiscal Year: 2006
    ....
  34. Striatal Acetylcholine and Behavioral Flexibility
    MICHAEL RAGOZZINO; Fiscal Year: 2005
    ....
  35. Aging, Serotonin and Reversal Learning
    MICHAEL RAGOZZINO; Fiscal Year: 2008
    ..These studies have the potential of developing a novel treatment for the learning and memory deficits observed in aging and Alzheimer's disease. [unreadable] [unreadable] [unreadable]..
  36. Microglial interactions with amyloid beta peptide
    Douglas Walker; Fiscal Year: 2003
    ..Overall, the findings from the proposed research could extend our knowledge of the inflammatory events occurring in the AD brain. ..
  37. MYELINATION--ASSEMBLY OF LIPIDS AND PROTEINS
    JOYCE BENJAMINS; Fiscal Year: 2003
    ..abstract_text> ..
  38. Mechanisms of Motor Neuron Death
    Lee Martin; Fiscal Year: 2006
    ..abstract_text> ..
  39. HIV-1 Infection Increases Brain Amyloid Beta
    Lynn Pulliam; Fiscal Year: 2006
    ..We believe that mechanisms derived from these experiments will have implications for long term survivors of HIV-1 infection and hopefully give us new clues for therapeutic strategies against HIV-associated dementia. ..
  40. AIDS encephalopathy and HIV disease: role of opioids
    Madhavan Nair; Fiscal Year: 2006
    ..IL-16, upregulation of HIV entry co-receptors, neurotoxins (matrix mcmlloproteasc-2 and-9,nitric oxide, quinolinic acid)TGF-beta I, apoptosis, STAT-4/6 and CD45 tyrosine phosphatase...
  41. HEROIN AIDS ENCEPHALOPATHY--NEUROPATHOGENESIS MECHANISMS
    Madhavan Nair; Fiscal Year: 2005
    ..upregulation of HIV entry coreceptors, neurotoxins (matrix metalloprotease-2 and-9 , nitric oxide, quinolinic acid) and apoptosis...
  42. Predicting HAD using Monocyte Profiling and Neuroimaging
    Lynn Pulliam; Fiscal Year: 2008
    ..These findings will help us develop a monocyte profile for HIV-1-infected individuals at risk for dementia to receive preventive therapy as well as serve as markers to assess effective therapies. [unreadable] [unreadable]..
  43. Neuroimmunology of Behavioral and Mood Disorders
    Robert Dantzer; Fiscal Year: 2008
    ..These innovative experiments are needed to understand how functional interactions between the immune system and brain regulate behavior and mood . ..
  44. Cocaine/Immuno and Neuropathogenesis of HIV-1 Infection
    Madhavan Nair; Fiscal Year: 2008
    ..These studies may lead to novel anti-HIV therapies such as targeting the CD4 independent, virus attachment receptor, DC-SIGN, or devising inhibitors of TDO and DC-SIGN or stimulating costimulatory molecules. ..
  45. MECHANISMS OF NEURONAL APOPTOSIS IN VIVO
    Lee Martin; Fiscal Year: 2009
    ..This work can define a new mitochondrial mechanism for target deprivation-induced neurodegeneration and can improve the understanding of the cellular and molecular mechanisms of neuronal apoptosis in vivo ..
  46. Arterial 5-HT Transporter Function
    Stephanie Watts; Fiscal Year: 2009
    ..abstract_text> ..
  47. DNA Damage/Repair and Cell Death
    Lee Martin; Fiscal Year: 2009
    ....
  48. AIDS, Immune Activation and Mental Health
    Robert Dantzer; Fiscal Year: 2010
    ....
  49. Immunopathogenesis of HIV-1 Infection: Role of Methamphetamine
    Madhavan P Nair; Fiscal Year: 2010
    ....