paraquat

Summary

Summary: A poisonous dipyridilium compound used as contact herbicide. Contact with concentrated solutions causes irritation of the skin, cracking and shedding of the nails, and delayed healing of cuts and wounds.

Top Publications

  1. pmc SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response
    Jae Hyung An
    Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 17:1882-93. 2003
  2. pmc Rotenone, paraquat, and Parkinson's disease
    Caroline M Tanner
    The Parkinson s Institute, Sunnyvale, California 94085, USA
    Environ Health Perspect 119:866-72. 2011
  3. pmc A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans
    Wen Yang
    Department of Biology, McGill University, Montreal, Quebec, Canada
    PLoS Biol 8:e1000556. 2010
  4. ncbi Inhibition of paraquat-induced autophagy accelerates the apoptotic cell death in neuroblastoma SH-SY5Y cells
    Rosa A Gonzalez-Polo
    CIBER de Enfermedades Neurodegenerativas, Departamento de Bioquimica y Biologia Molecular y Genetica, EU Enfermería y TO, Universidad de Extremadura, Avda Universidad s n 10071 Cáceres, Spain
    Toxicol Sci 97:448-58. 2007
  5. pmc Paraquat, but not maneb, induces synucleinopathy and tauopathy in striata of mice through inhibition of proteasomal and autophagic pathways
    Jonathan Wills
    Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center, Washington DC, United States of America
    PLoS ONE 7:e30745. 2012
  6. pmc Genome-wide transcriptional profiling of the Escherichia coli responses to superoxide stress and sodium salicylate
    P J Pomposiello
    Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Bacteriol 183:3890-902. 2001
  7. ncbi Interferon-γ plays a role in paraquat-induced neurodegeneration involving oxidative and proinflammatory pathways
    Emily N Mangano
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Neurobiol Aging 33:1411-26. 2012
  8. pmc Increased expression of SVCT2 in a new mouse model raises ascorbic acid in tissues and protects against paraquat-induced oxidative damage in lung
    Fiona Edith Harrison
    Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 7:e35623. 2012
  9. pmc Paraquat induces oxidative stress, neuronal loss in substantia nigra region and parkinsonism in adult rats: neuroprotection and amelioration of symptoms by water-soluble formulation of coenzyme Q10
    Mallika Somayajulu-Nitu
    Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada
    BMC Neurosci 10:88. 2009
  10. pmc Lysosomal degradation of alpha-synuclein in vivo
    Sally K Mak
    The Parkinson s Institute, Sunnyvale, California 94085, USA
    J Biol Chem 285:13621-9. 2010

Detail Information

Publications362 found, 100 shown here

  1. pmc SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response
    Jae Hyung An
    Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 17:1882-93. 2003
    ..This oxidative stress response thus appears to be both widely conserved and ancient, suggesting that the mesendodermal specification role of SKN-1 was predated by its function in these detoxification mechanisms...
  2. pmc Rotenone, paraquat, and Parkinson's disease
    Caroline M Tanner
    The Parkinson s Institute, Sunnyvale, California 94085, USA
    Environ Health Perspect 119:866-72. 2011
    ..Certain pesticides may affect these mechanisms, but no pesticide has been definitively associated with PD in humans...
  3. pmc A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans
    Wen Yang
    Department of Biology, McGill University, Montreal, Quebec, Canada
    PLoS Biol 8:e1000556. 2010
    ..as it is abolished by the antioxidants NAC and vitamin C, and phenocopied by mild treatment with the prooxidant paraquat. Furthermore, the absence of effect of NAC and the additivity of the effect of paraquat on a variety of long- and ..
  4. ncbi Inhibition of paraquat-induced autophagy accelerates the apoptotic cell death in neuroblastoma SH-SY5Y cells
    Rosa A Gonzalez-Polo
    CIBER de Enfermedades Neurodegenerativas, Departamento de Bioquimica y Biologia Molecular y Genetica, EU Enfermería y TO, Universidad de Extremadura, Avda Universidad s n 10071 Cáceres, Spain
    Toxicol Sci 97:448-58. 2007
    ..In this sense, paraquat (PQ) (1,1'-dimethyl-4,4'-bipyridinium dichloride), a widely used herbicide that is structurally similar to the ..
  5. pmc Paraquat, but not maneb, induces synucleinopathy and tauopathy in striata of mice through inhibition of proteasomal and autophagic pathways
    Jonathan Wills
    Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center, Washington DC, United States of America
    PLoS ONE 7:e30745. 2012
    ..The agrichemicals maneb and paraquat selectively target dopaminergic neurons, leading to parkinsonism, through ill-defined mechanisms...
  6. pmc Genome-wide transcriptional profiling of the Escherichia coli responses to superoxide stress and sodium salicylate
    P J Pomposiello
    Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Bacteriol 183:3890-902. 2001
    ..coli response to the superoxide-generating agent paraquat (PQ), an inducer of the soxRS system, and to the weak acid salt sodium salicylate (NaSal), an inducer of the ..
  7. ncbi Interferon-γ plays a role in paraquat-induced neurodegeneration involving oxidative and proinflammatory pathways
    Emily N Mangano
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Neurobiol Aging 33:1411-26. 2012
    ..protected substantia nigra pars compacta (SNc) dopamine (DA) neurons from the toxic effects of the pesticide, paraquat, and normalized changes in inflammatory and oxidative factors within this brain region...
  8. pmc Increased expression of SVCT2 in a new mouse model raises ascorbic acid in tissues and protects against paraquat-induced oxidative damage in lung
    Fiona Edith Harrison
    Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 7:e35623. 2012
    ..Six treatments with Paraquat (3x10 and 3x15 mg/kg i.p.) were used to induce oxidative stress in mice...
  9. pmc Paraquat induces oxidative stress, neuronal loss in substantia nigra region and parkinsonism in adult rats: neuroprotection and amelioration of symptoms by water-soluble formulation of coenzyme Q10
    Mallika Somayajulu-Nitu
    Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada
    BMC Neurosci 10:88. 2009
    ....
  10. pmc Lysosomal degradation of alpha-synuclein in vivo
    Sally K Mak
    The Parkinson s Institute, Sunnyvale, California 94085, USA
    J Biol Chem 285:13621-9. 2010
    ..e. treatment of mice with the herbicide paraquat) or transgenic protein overexpression, the intralysosomal content of alpha-synuclein was also significantly ..
  11. pmc Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain
    Pablo R Castello
    Department of Pharmaceutical Sciences, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    J Biol Chem 282:14186-93. 2007
    b>Paraquat (PQ(2+)) is a prototypic toxin known to exert injurious effects through oxidative stress and bears a structural similarity to the Parkinson disease toxicant, 1-methyl-4-pheynlpyridinium...
  12. pmc Genome wide analysis of common and specific stress responses in adult drosophila melanogaster
    Fabrice Girardot
    Institut Jacques Monod, 2 place Jussieu, 75251 Paris, France
    BMC Genomics 5:74. 2004
    ..In addition, the functional significance of observed transcriptional changes is still elusive...
  13. pmc OxyR and SoxRS regulation of fur
    M Zheng
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Bacteriol 181:4639-43. 1999
    ..In cells treated with the superoxide-generating compound paraquat, we observed the induction of a longer transcript encompassing both fur and its immediate upstream gene fldA, ..
  14. ncbi Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models?
    Francesca Cicchetti
    Centre de Recherche du CHUL CHUQ, Axe Neuroscience, RC 9800, Quebec G1V 4G2, Canada
    Trends Pharmacol Sci 30:475-83. 2009
    ..Here, we review recent advances in the predominant models employing the insecticide Rotenone, the herbicide Paraquat and the fungicide Maneb, discuss their scientific merit and evaluate their relevance in the study of PD ..
  15. ncbi Paraquat-induced oxidative stress in drosophila melanogaster: effects of melatonin, glutathione, serotonin, minocycline, lipoic acid and ascorbic acid
    Ernesto Bonilla
    Neurochemistry Section, Instituto de Investigaciones Clinicas Dr Americo Negrette, Universidad del Zulia, Apartado 23, Maracaibo, Venezuela
    Neurochem Res 31:1425-32. 2006
    ..of melatonin, glutathione, serotonin, minocycline, lipoic acid and ascorbic acid in counteracting the toxicity of paraquat in Drosophila melanogaster was examined...
  16. ncbi Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment
    R J Dinis-Oliveira
    REQUIMTE, Departamento de Toxicologia, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal
    Crit Rev Toxicol 38:13-71. 2008
    b>Paraquat dichloride (methyl viologen; PQ) is an effective and widely used herbicide that has a proven safety record when appropriately applied to eliminate weeds...
  17. ncbi Paraquat-induced retinal degeneration is exaggerated in CX3CR1-deficient mice and is associated with increased retinal inflammation
    Mei Chen
    Centre for Vision and Vascular Science, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, Northern Ireland, United Kingdom
    Invest Ophthalmol Vis Sci 54:682-90. 2013
    ..To investigate the role of the Fractalkine receptor CX3CR1 pathway in oxidative insults-mediated retinal degeneration and immune activation...
  18. ncbi Failure of continuous venovenous hemofiltration to prevent death in paraquat poisoning
    Ja Ryong Koo
    Division of Nephrology, College of Medicine, Hallym University, Chunchon, Kangwon Do, Seoul, Korea
    Am J Kidney Dis 39:55-9. 2002
    b>Paraquat poisoning is characterized by multiorgan failure and pulmonary fibrosis with respiratory failure. Multiorgan failure with circulatory collapse is a major cause of early death within 3 days of paraquat ingestion...
  19. ncbi Improved survival in severe paraquat poisoning with repeated pulse therapy of cyclophosphamide and steroids
    Ja Liang Lin
    Department of Nephrology, Division of Clinical Toxicology, Chang Gung Memorial Hospital, 199, Tung Hwa North Road, Taipei, Taiwan, ROC
    Intensive Care Med 37:1006-13. 2011
    To clarify the efficacy of repeated methylprednisolone (MP) and cyclophosphamide (CP) pulse therapy and daily dexamethasone (DEX) therapy in patients with severe paraquat (PQ) poisoning.
  20. ncbi Inflammatory priming of the substantia nigra influences the impact of later paraquat exposure: Neuroimmune sensitization of neurodegeneration
    Emily N Mangano
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Neurobiol Aging 30:1361-78. 2009
    ..with the inflammatory agent, lipopolysaccharide (LPS), influenced the impact of later exposure to the pesticide, paraquat, which has been reported to provoke DA loss...
  21. ncbi Comparison of the effects of the superoxide dismutase mimetics EUK-134 and tempol on paraquat-induced nephrotoxicity
    Mohamed Samai
    Department of Pharmacology and Therapeutics, University of Brighton, Brighton BN2 4GJ, East Sussex, UK
    Free Radic Biol Med 43:528-34. 2007
    b>Paraquat-induced nephrotoxicity involves severe renal cell damage caused by reactive oxygen species (ROS), specifically via increasing concentrations of superoxide anions in the kidney...
  22. ncbi Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans
    J Feng
    Department of Biology, McGill University, 1205 Avenue Dr Penfield, H3A 1B1, , , Canada
    Dev Cell 1:633-44. 2001
    ..These findings indicate that both isp-1 and daf-2 mutations increase life span by lowering oxidative stress and result in the maximum life span increase that can be produced in this way...
  23. pmc Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat
    Won Seok Choi
    Toxicology Program, Department of Environmental and Occupational Health Sciences, Graduate Program in Neurobiology and Behavior, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195 7234, USA
    Proc Natl Acad Sci U S A 105:15136-41. 2008
    ..neurons were more sensitive than other neurons in these cultures to cell death induced by rotenone, MPP(+), or paraquat treatments, the absence of complex I activity did not protect the dopaminergic neurons, as would be expected if ..
  24. pmc Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California
    Sadie Costello
    Department of Environmental Health Sciences, University of California, Berkeley, 94720 7360, USA
    Am J Epidemiol 169:919-26. 2009
    ..They generated estimates for maneb and paraquat exposures incurred between 1974 and 1999...
  25. ncbi Repeated pulse of methylprednisolone and cyclophosphamide with continuous dexamethasone therapy for patients with severe paraquat poisoning
    Ja Liang Lin
    Division of Clinical Toxicology and Nephrology, Department of Medicine, Chang Gung Memorial Hospital, Lin Kou Medical Center, Chang Gung University, School of Medicine, Taipei, Taiwan, ROC
    Crit Care Med 34:368-73. 2006
    b>Paraquat is widely used in the world, and all treatments for paraquat poisoning have been unsuccessful. Many patients have died of paraquat poisoning in developing countries...
  26. pmc Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity
    J P Phillips
    Department of Molecular Biology and Genetics, University of Guelph, ON, Canada
    Proc Natl Acad Sci U S A 86:2761-5. 1989
    ..cSODn108 confers recessive sensitivity to the superoxide anion (O2-)-generator paraquat and to the transition metal compound CuSO4, which indicates that the cSOD-null condition in fact leads to ..
  27. pmc JNK3 mediates paraquat- and rotenone-induced dopaminergic neuron death
    Won Seok Choi
    Toxicology Program in the Department of Environmental and Occupational Health Sciences, Graduate Program in Neurobiology and Behavior, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, USA
    J Neuropathol Exp Neurol 69:511-20. 2010
    ..3 (JNK3), a neural-specific JNK isoform, in dopaminergic neuron death induced by the pesticides rotenone and paraquat. The role of JNK3 was evaluated using RNA silencing and gene deletion to block JNK3 signaling...
  28. ncbi Nitric oxide in paraquat-mediated toxicity: A review
    Jose M Moran
    Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Departamento de Bioquímica y Biología Moleculary Genética, EU Enfermería y TO, Universidad de Extremadura, Avda Universidad s n 10071 Cáceres, Spain
    J Biochem Mol Toxicol 24:402-9. 2010
    b>Paraquat, a cationic herbicide, produces degenerative lesions in the lung and in the nervous system after systemic administration to man and animals. Many cases of acute poisoning and death have been reported over the past few decades...
  29. ncbi Plasma surfactant D in patients following acute paraquat intoxication
    Hyo Wook Gil
    Department of Internal Medicine, Soonchunhyang, University Cheonan Hospital, Cheonan, Republic of Korea
    Clin Toxicol (Phila) 45:463-7. 2007
    Free radical-induced lung injury is a major problem that occurs because of paraquat intoxication. Serum surfactant protein D (SP-D) reflects the severity of various lung diseases...
  30. ncbi Small heat shock proteins, IbpA and IbpB, are involved in resistances to heat and superoxide stresses in Escherichia coli
    M Kitagawa
    Department of Biotechnology and High Technology Research Center, Kansai University, Yamate cho 3 3 35, Suita, Osaka, Japan
    FEMS Microbiol Lett 184:165-71. 2000
    ..The heat sensitivity of a rpoH amber mutant was partially suppressed by the overexpression of plac::ibpAB. These results suggest that IbpA and IbpB may be involved in the resistances to heat and oxidative stress...
  31. ncbi Studies on the glutathione S-transferase proteome of adult Drosophila melanogaster: responsiveness to chemical challenge
    Zazali Alias
    School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
    Proteomics 7:3618-28. 2007
    ..DmGSTD2 was detected only after pretreatment of the flies with Phenobarbital (PhB). Treatment with Paraquat (PQ) led to an increase in the total GST activity, as measured with the substrates 1-chloro-2,4-dinitrobenzene (..
  32. ncbi Paraquat poisoning
    Chanchai Sittipunt
    Department of Internal Medicine, Chulalongkorn University School of Medicine, Bangkok, Thailand
    Respir Care 50:383-5. 2005
  33. pmc Sequential organ failure assessment score can predict mortality in patients with paraquat intoxication
    Cheng Hao Weng
    Department of Nephrology, Chang Gung Memorial Hospital, Linkou Medical Center, Taipei, Taiwan
    PLoS ONE 7:e51743. 2012
    b>Paraquat poisoning is characterized by multi-organ failure and pulmonary fibrosis with respiratory failure, resulting in high mortality and morbidity...
  34. ncbi Low doses of paraquat and polyphenols prolong life span and locomotor activity in knock-down parkin Drosophila melanogaster exposed to oxidative stress stimuli: implication in autosomal recessive juvenile parkinsonism
    Leonardo Bonilla-Ramirez
    School of Medicine, Medical Research Institute, Neuroscience Research Group, University of Antioquia UdeA, Medellin, Colombia
    Gene 512:355-63. 2013
    ..potent neuroprotective agents in Drosophila melanogaster wild type Canton-S acutely or chronically treated with paraquat (PQ), a selective toxin for elimination of dopaminergic (DAergic) neurons by oxidative stress (OS), as model of ..
  35. pmc Traumatic brain injury, paraquat exposure, and their relationship to Parkinson disease
    Pei Chen Lee
    Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles, Los Angeles, CA, USA
    Neurology 79:2061-6. 2012
    ..A recent animal study suggested that the combination of TBI with subthreshold paraquat exposure increases dopaminergic neurodegeneration...
  36. pmc Alterations in bioenergetic function induced by Parkinson's disease mimetic compounds: lack of correlation with superoxide generation
    Brian P Dranka
    Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, WI, USA
    J Neurochem 122:941-51. 2012
    ..inhibitor, or 6-hydroxydopamine (6-OHDA) as a mechanistically distinct PD neurotoxicant, but not with exposure to paraquat. In addition, the extracellular acidification rate, used as a marker of glycolysis, was stimulated to compensate ..
  37. ncbi Spectrum of toxic hepatitis following intentional paraquat ingestion: analysis of 187 cases
    Chin Jung Yang
    Department of Nephrology and Division of Clinical Toxicology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Liver Int 32:1400-6. 2012
    ..study examined the clinical features, the degrees of toxic hepatitis, physiological markers and clinical outcomes after intentional paraquat poisoning and sought to determine what association, if any, might exist between these findings.
  38. ncbi Effects of paraquat and capsaicin on the expression of genes related to inflammatory, immune responses and cell death in immortalized human HaCat keratinocytes
    N Paolillo
    IRCCS C Mondino Institute of Neurology Foundation, Pavia
    Int J Immunopathol Pharmacol 24:861-8. 2011
    ..experiments were aimed to characterize in immortalized human HaCat keratinocytes the gene expression induced by paraquat and capsaicin, two agents known to induce cell death or to affect inflammatory and pain pathways, respectively...
  39. ncbi Loss of AtPDR11, a plasma membrane-localized ABC transporter, confers paraquat tolerance in Arabidopsis thaliana
    Jing Xi
    School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China
    Plant J 69:782-91. 2012
    b>Paraquat is one of the most widely used herbicides in the world. However, no paraquat transporter has been isolated in plants...
  40. ncbi Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function
    Cheng Wang
    Neurodegeneration Research Laboratory, National Neuroscience Institute, Singapore
    Hum Mol Genet 14:3885-97. 2005
    ..we demonstrate here that several PD-linked stressors, including neurotoxins (MPP+, rotenone, 6-hydroxydopamine), paraquat, NO, dopamine and iron, induce alterations in parkin solubility and result in its intracellular aggregation...
  41. pmc Wld(S) reduces paraquat-induced cytotoxicity via SIRT1 in non-neuronal cells by attenuating the depletion of NAD
    Qiujing Yu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 6:e21770. 2011
    ..Here we found that Wld(S) significantly reduced the cytotoxicity of bipyridylium herbicides paraquat and diquat in mouse embryonic fibroblasts, but had no effect on the cytotoxicity induced by chromium (VI), ..
  42. ncbi Superoxide sensitivity of the Escherichia coli aconitase
    P R Gardner
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710
    J Biol Chem 266:19328-33. 1991
    ....
  43. pmc Postmortem analyses unveil the poor efficacy of decontamination, anti-inflammatory and immunosuppressive therapies in paraquat human intoxications
    Ricardo Jorge Dinis-Oliveira
    Faculty of Medicine, University of Porto, Porto, Portugal
    PLoS ONE 4:e7149. 2009
    Fatalities resulting from paraquat (PQ) self-poisonings represent a major burden of this herbicide...
  44. pmc Medical management of paraquat ingestion
    Indika B Gawarammana
    Department of Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    Br J Clin Pharmacol 72:745-57. 2011
    Poisoning by paraquat herbicide is a major medical problem in parts of Asia while sporadic cases occur elsewhere. The very high case fatality of paraquat is due to inherent toxicity and lack of effective treatments...
  45. pmc Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3
    Phillip M Rappold
    Department of Neurology in the Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 108:20766-71. 2011
    The herbicide paraquat (PQ) has increasingly been reported in epidemiological studies to enhance the risk of developing Parkinson's disease (PD)...
  46. ncbi Gene expression in rat lungs during early response to paraquat-induced oxidative stress
    Masafumi Tomita
    Department of Medical Toxicology, Kawasaki Medical School, Kurashiki 701 0192, Japan
    Int J Mol Med 17:37-44. 2006
    b>Paraquat (PQ) is a well-known pneumotoxicant and provides an established model of oxidative stress. This study focused on the transcriptional response to PQ-driven oxidative stress in rat lungs during an early phase post-injection...
  47. ncbi Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse
    Naveen Kumar Singhal
    Indian Institute of Toxicology Research Council of Scientific and Industrial Research, M G Marg, Lucknow, UP, India Jamia Hamdard, New Delhi, India
    J Pineal Res 50:97-109. 2011
    Oxidative stress is reported as one of the most widely accepted mechanisms of maneb (MB)- and paraquat (PQ)-induced nigrostriatal dopaminergic neurodegeneration leading to the Parkinson's disease (PD) phenotype...
  48. pmc Lifespan extension and paraquat resistance in a ubiquinone-deficient Escherichia coli mutant depend on transcription factors ArcA and TdcA
    Stavros Gonidakis
    Integrative and Evolutionary Biology, Department of Biological Sciences, University of Southern California, Los Angeles, 90089, USA
    Aging (Albany NY) 3:291-303. 2011
    ..The longevity of the mutant, as well as its resistance to the superoxide-generating agent paraquat, is partially dependent on the hypoxia-inducible transcription factor ArcA...
  49. ncbi Neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) on paraquat-induced apoptosis in PC12 cells
    Rong Rong Hou
    Laboratory of Integrated Traditional Chinese Medicine and Western Medicine on Elderly Encephalopathy, Research Center of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, 710032 Xi an, Shaanxi, China
    Cell Biol Int 32:22-30. 2008
    ..b>Paraquat (PQ) is a widely used herbicide that possesses a similar structure to MPP(+) and is toxic to mesencephalic ..
  50. ncbi Protective effect of quercetin against paraquat-induced lung injury in rats
    Hee K Park
    College of Pharmacy, Seoul National University, Seoul, Republic of Korea
    Life Sci 87:181-6. 2010
    b>Paraquat (PQ) is known to induce pulmonary injury via a redox cyclic reaction. The present study was aimed to determine the protective effects of quercetin against PQ-induced pulmonary injury in association with its antioxidant activity.
  51. ncbi Decreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola rosea
    Samuel E Schriner
    Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92697, USA
    Free Radic Res 43:836-43. 2009
    ..that it lowered mitochondrial superoxide levels and afforded elevated protection against the superoxide generator paraquat in both sexes...
  52. ncbi Combined initial cyclophosphamide with repeated methylprednisolone pulse therapy for severe paraquat poisoning from dermal exposure
    Nan Chieh Lin
    Poison Center, Department of Internal Medicine, Chang Gung Memorial Hospital, Lin Kou Medical Center, Chang Gung Medical College and University, Taipei, Taiwan, ROC
    J Toxicol Clin Toxicol 41:877-81. 2003
    The article presents a patient with severe paraquat poisoning from dermal exposure, who had chemical bums to more than 10% of his body surface area, serum paraquat level 0.13 microg/mL 60 hr after exposure, and severe hypoxemia (PaO2 41...
  53. ncbi Neurotoxic in vivo models of Parkinson's disease recent advances
    Jason R Cannon
    Pittsburgh Institute for Neurodegenerative Diseases, Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
    Prog Brain Res 184:17-33. 2010
    ..The roles these new advances in modeling may have in future PD research are examined in this chapter...
  54. ncbi Evaluation of epidemiologic and animal data associating pesticides with Parkinson's disease
    Abby A Li
    Health Sciences Practice, Exponent, Inc, San Francisco, California 94114, USA
    J Occup Environ Med 47:1059-87. 2005
    ..We conclude that the animal and epidemiologic data reviewed do not provide sufficient evidence to support a causal association between pesticide exposure and PD...
  55. pmc Cytotoxicity of paraquat in microglial cells: Involvement of PKCdelta- and ERK1/2-dependent NADPH oxidase
    Rebecca L Miller
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA
    Brain Res 1167:129-39. 2007
    ..Exposure to paraquat, an herbicide with structure similar to the dopaminergic neurotoxin, 1-methyl-4-phenylpyridinium (MPP+), has been ..
  56. ncbi Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis
    Mireia Niso-Santano
    Departamento de Bioquimica y Biologia Molecular y Genetica, E U Enfermería y Terapia Ocupacional, Universidad de Extremadura, 10071 Caceres, Spain
    Free Radic Biol Med 48:1370-81. 2010
    ..have addressed this question in human dopaminergic neuroblastoma SH-SY5Y cells exposed to the parkinsonian toxin paraquat (PQ)...
  57. ncbi Paraquat and Parkinson's disease
    C Berry
    Queen Mary, University of London, London, E1 4NS, UK
    Cell Death Differ 17:1115-25. 2010
    ..Among other pesticides, paraquat (PQ) has been linked to PD by epidemiological studies and experimental work in rodents, in which it causes ..
  58. ncbi The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster
    Tapiwanashe Magwere
    Centre for Research on Ageing, University College London, Department of Biology, Darwin Building, Gower Street, London WC1E 6BT, United Kingdom
    Mech Ageing Dev 127:356-70. 2006
    ..increase in toxicity in wild type flies, an effect that was exacerbated in the presence of the redox-cycling drug paraquat. However, important findings from this study were that in SOD-deficient flies, where the antioxidant drugs ..
  59. pmc Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression
    P O Fernagut
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1769, USA
    Synapse 61:991-1001. 2007
    Genetic variability in the alpha-synuclein gene and long-term exposure to the pesticide paraquat constitute possible risk factors for sporadic Parkinson's disease...
  60. pmc Microglial activation as a priming event leading to paraquat-induced dopaminergic cell degeneration
    Maya G Purisai
    The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
    Neurobiol Dis 25:392-400. 2007
    ..Repeated injections with the herbicide paraquat cause oxidative stress and a selective loss of dopaminergic neurons in mice...
  61. ncbi The role of microglia in paraquat-induced dopaminergic neurotoxicity
    Xue Fei Wu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Antioxid Redox Signal 7:654-61. 2005
    The herbicide paraquat (PQ) has been implicated as a potential risk factor for the development of Parkinson's disease. In this study, PQ (0...
  62. ncbi Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide
    J B de Haan
    Molecular Genetics and Development Group, Institute of Reproduction and Development, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia
    J Biol Chem 273:22528-36. 1998
    ..Gpx1 in protection against oxidative stress by showing that Gpx1 (-/-) mice are highly sensitive to the oxidant paraquat. Lethality was already detected within 24 h in mice exposed to paraquat at 10 mg...
  63. pmc Parkinson's disease risk from ambient exposure to pesticides
    Anthony Wang
    Epidemiology, UCLA School of Public Health, Box 951772, 650 Charles E Young Drive, Los Angeles, CA 90095 1772, USA
    Eur J Epidemiol 26:547-55. 2011
    ..our geographic information system model, we estimated ambient exposures to the pesticides ziram, maneb, and paraquat at work places and residences from 1974 to 1999...
  64. ncbi Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient mice
    Wonsuk Yang
    Department of Neurology, The University of Chicago, IL 60637, USA
    Hum Mol Genet 16:2900-10. 2007
    ..To simulate the interaction of genetic factors and environmental factors, we treated DJ-1-deficient mice with paraquat. Even in relatively young mice, this combination produced dopamine loss and motor dysfunction...
  65. ncbi Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat
    Alison L McCormack
    The Parkinson s Institute, Sunnyvale, California 94089, USA
    Neurobiol Dis 10:119-27. 2002
    ..nigrostriatal degeneration could be reproduced by systemic exposure of mice to the widely used herbicide paraquat. Repeated intraperitoneal paraquat injections killed dopaminergic neurons in the substantia nigra (SN) pars ..
  66. ncbi Oxidative stress tolerance and longevity in Arabidopsis: the late-flowering mutant gigantea is tolerant to paraquat
    J Kurepa
    Department of Genetics, Flanders Interuniversity Institute for Biotechnology VIB, Universiteit Gent, Belgium
    Plant J 14:759-64. 1998
    ..tolerance, the response was tested of 11 late-flowering mutants to the superoxide radical-generating herbicide paraquat. A tight correlation between flowering time and paraquat tolerance was found when plants were exposed to low ..
  67. ncbi The clinical features of acute kidney injury in patients with acute paraquat intoxication
    Su Ji Kim
    Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea
    Nephrol Dial Transplant 24:1226-32. 2009
    b>Paraquat (PQ) is a non-selective herbicide that generates reactive oxygen species in vivo...
  68. ncbi Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans
    L S Salinas
    Departamento de Biologia Celular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Apartado Postal 70 600, Mexico, DF 04510, Mexico
    Cell Death Differ 13:2129-39. 2006
    ..We conclude that in C. elegans responses to various stresses that do not involve genotoxicity include an increase in germ cell apoptosis through the physiological pathway...
  69. ncbi Identification of early molecular pathways affected by paraquat in rat lung
    Guy Mainwaring
    Syngenta CTL, Alderley Park, Cheshire SK10 4TJ, United Kingdom
    Toxicology 225:157-72. 2006
    ..profiling, combined with pathway analysis tools, to identify in rats the molecular events associated with paraquat toxicity in the lung. Early (2, 8 and 18h) gene expression changes induced following intraperitoneal (i.p...
  70. ncbi Systemic exposure to paraquat and maneb models early Parkinson's disease in young adult rats
    Francesca Cicchetti
    Centre de Recherche en Neurosciences, CHUL, RC 9800, 2705 Boulevard Laurier, Sainte Foy, QC, Canada G1V 4G2
    Neurobiol Dis 20:360-71. 2005
    ..b>Paraquat (PQ--herbicide) and maneb (MB--fungicide) are among the compounds suspected to induce neuronal degeneration and ..
  71. ncbi The effectiveness of combined treatment with methylprednisolone and cyclophosphamide in oral paraquat poisoning
    Saeed Afzali
    Poisoning Ward, Sina Hospital, Hamadan, Iran
    Arch Iran Med 11:387-91. 2008
    b>Paraquat is a bipyridil herbicide and in appropriate and careful usage, will not be health threatening. Most adult cases of intoxication are due to suicidal attempts rather than accidental exposure...
  72. ncbi Effect of methylsulfonylmethane on paraquat-induced acute lung and liver injury in mice
    Keyvan Amirshahrokhi
    Department of Pharmacology, School of Medicine, Ardabil University of Medical Sciences, P O Box 5618953141, Ardabil, Iran
    Inflammation 36:1111-21. 2013
    ..This study was carried out to investigate the effect of MSM on paraquat (PQ)-induced acute lung and liver injury in mice. A single dose of PQ (50 mg/kg, i.p...
  73. ncbi Effect assessment of the herbicide paraquat on a green alga using differential gene expression and biochemical biomarkers
    An Jamers
    Laboratory for Ecophysiology, Biochemistry and Toxicology, Department of Biology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Environ Toxicol Chem 29:893-901. 2010
    Effects of the herbicide paraquat were assessed on the green freshwater alga Chlamydomonas reinhardtii using different endpoints of toxicity...
  74. pmc Association of the superoxide dismutase (V16A) and catalase (C262T) genetic polymorphisms with the clinical outcome of patients with acute paraquat intoxication
    Joong Rock Hong
    Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea
    Korean J Intern Med 25:422-8. 2010
    Many patients with acute paraquat (PQ) intoxication die even at low PQ concentrations, whereas others with similar concentrations recover...
  75. pmc Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats
    Shulin Liu
    Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China
    J Biomed Biotechnol 2011:305086. 2011
    Exposure to paraquat leads to acute lung injury and oxidative stress is widely accepted as a contributor to paraquat-induced acute lung injury...
  76. ncbi The reversal of paraquat-induced mitochondria-mediated apoptosis by cycloartenyl ferulate, the important role of Nrf2 pathway
    Guang liang Hong
    Department of Emergency Medicine, The First Affiliated Hospital of Wenzhou Medical University, 2 Fuxue lane, Lucheng District, Wenzhou 325000, Zhejiang, China Electronic address
    Exp Cell Res 319:2845-55. 2013
    In this study, we demonstrate the protective effects of Cycloartenyl ferulate (CF) against Paraquat (PQ)-induced cytotoxicity and elucidate the underlying molecular mechanisms...
  77. ncbi Complement inhibition alleviates paraquat-induced acute lung injury
    Shihui Sun
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China
    Am J Respir Cell Mol Biol 45:834-42. 2011
    The widely used herbicide, paraquat (PQ), is highly toxic and claims thousands of lives from both accidental and voluntary ingestion...
  78. ncbi Paraquat-induced oxidative stress and dysfunction of the glutathione redox cycle in pulmonary microvascular endothelial cells
    Maki Tsukamoto
    Division of Environmental Hygiene, Hokkaido College of Pharmacy, 7 1 Katsuraoka cho, Otaru, Hokkaido, 047 0264, Japan
    Toxicol Appl Pharmacol 178:82-92. 2002
    ..that include the glutathione redox cycle in cultured pulmonary microvascular endothelial cells after exposure to paraquat at 0.1 and 0.5 mM were examined as a function of time...
  79. ncbi Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice
    Yan Chen
    Key Laboratory of Gene Engineering of the Ministry of Education, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat Sen University, Guangzhou 510275, PR China
    Food Chem Toxicol 58:133-40. 2013
    The present study evaluates protective effects of naringin against paraquat (PQ)-induced acute lung injury (ALI) and pulmonary fibrosis in mice...
  80. ncbi Mucuna pruriens seed extract reduces oxidative stress in nigrostriatal tissue and improves neurobehavioral activity in paraquat-induced Parkinsonian mouse model
    Satyndra Kumar Yadav
    Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
    Neurochem Int 62:1039-47. 2013
    ..pruriens (Mp) seed in Parkinsonian mouse model developed by chronic exposure to paraquat (PQ)...
  81. pmc Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease
    Paula Desplats
    Department of Neuroscience, University of California San Diego, 9500 Gilman Dr, MTF 344, La Jolla, CA 92093 0624, USA
    Mol Neurodegener 7:49. 2012
    ..Concurrent exposure to Paraquat (PQ) and Maneb (MB) in rural workers increases the risk for PD and exposure of adult mice to MB/PQ results in ..
  82. ncbi Flavodoxin overexpression confers tolerance to oxidative stress in beneficial soil bacteria and improves survival in the presence of the herbicides paraquat and atrazine
    T Coba de la Peña
    Instituto de Ciencias Agrarias, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Appl Microbiol 115:236-46. 2013
    To determine whether expression of a cyanobacterial flavodoxin in soil bacteria of agronomic interest confers protection against the widely used herbicides paraquat and atrazine.
  83. ncbi Oxidative stress response of Mycosphaerella fijiensis, the causal agent of black leaf streak disease in banana plants, to hydrogen peroxide and paraquat
    Miguel J Beltrán-García
    Departamento de Química ICET, Universidad Autonoma de Guadalajara, Patria 1201, Lomas del Valle 44100, Guadalajara, Jalisco, Mexico
    Can J Microbiol 55:887-94. 2009
    ..The oxidative stress responses to H2O2, paraquat, and hydroquinone were characterized in terms of the activities of catalase and superoxide dismutase (SOD)...
  84. ncbi Paraquat neurotoxicity is distinct from that of MPTP and rotenone
    Jason R Richardson
    Center for Neurodegenerative Disease, School of Medicine and Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Toxicol Sci 88:193-201. 2005
    b>Paraquat, MPTP, and rotenone reproduce features of Parkinson's disease (PD) in experimental animals...
  85. ncbi Involvement of nitric oxide in maneb- and paraquat-induced Parkinson's disease phenotype in mouse: is there any link with lipid peroxidation?
    Satya Prakash Gupta
    Indian Institute of Toxicology Research Council of Scientific and Industrial Research, Mahatma Gandhi Marg, Lucknow, UP, India
    Neurochem Res 35:1206-13. 2010
    The study aimed to investigate the involvement of nitric oxide (NO) in maneb (MB)- and paraquat (PQ)-induced Parkinson's disease (PD) phenotype in mouse and its subsequent contribution to lipid peroxidation...
  86. pmc Traumatic brain injury in adult rats causes progressive nigrostriatal dopaminergic cell loss and enhanced vulnerability to the pesticide paraquat
    Che Brown Hutson
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurotrauma 28:1783-801. 2011
    ..We have examined the acute and long-term effects of TBI and exposure to low doses of the pesticide paraquat, separately and in combination, on nigrostriatal dopaminergic neurons in adult male rats...
  87. ncbi Regulation of the AcrAB multidrug efflux pump in Salmonella enterica serovar Typhimurium in response to indole and paraquat
    Eiji Nikaido
    Laboratory of Microbiology and Infectious Diseases, Institute of Scientific and Industrial Research, Osaka University, Osaka 567 0047, Japan
    Microbiology 157:648-55. 2011
    ..Furthermore, we showed that paraquat, a superoxide generator, induces acrAB but not ramA...
  88. ncbi Relationship between autophagy and apoptotic cell death in human neuroblastoma cells treated with paraquat: could autophagy be a "brake" in paraquat-induced apoptotic death?
    Rosa A Gonzalez-Polo
    CIBER de Enfermedades Neurodegenerativas CIBERNED, Departamento de Bioquimica y Biologia Molecular y Genetica, EU Enfermería y TO, Universidad de Extremadura, Caceres, Spain
    Autophagy 3:366-7. 2007
    b>Paraquat (PQ) (1, 1'-dimethyl-4, 4'-bipyridinium dichloride), a widely used herbicide, has been suggested as a potential etiologic factor for the development of Parkinson's disease (PD)...
  89. ncbi Edaravone, a novel antidote against lung injury and pulmonary fibrosis induced by paraquat?
    Qiaoming Zhi
    Department of Surgery of Ruijin Hospital, Shanghai Jiaotong University, Shanghai Institute of Digestive Surgery, Shanghai 200025, PR China
    Int Immunopharmacol 11:96-102. 2011
    ..In this study, we evaluated whether edaravone could protect against lung injury and pulmonary fibrosis in paraquat-treated rats...
  90. ncbi Hypokalemia and hypothermia are associated with 30-day mortality in patients with acute paraquat poisoning
    Meng Wei Chang
    Department of Emergency Medicine, Chang Gung Memorial Hospital, Linko Medical Center, Taoyuan, Taiwan
    Am J Med Sci 335:451-6. 2008
    Clinical predictors associated with acute paraquat (PQ) poisoning have not been systematically studied.
  91. pmc Coupling endoplasmic reticulum stress to the cell death program in dopaminergic cells: effect of paraquat
    Shankar J Chinta
    The Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Neuromolecular Med 10:333-42. 2008
    ..b>Paraquat belongs to a class of bipyridyl herbicides and triggers oxidative stress and dopaminergic cell death...
  92. pmc Caffeine protects against combined paraquat and maneb-induced dopaminergic neuron degeneration
    Anil Kachroo
    MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Exp Neurol 223:657-61. 2010
    ..whether caffeine alters dopaminergic neuron loss induced by exposure to environmentally relevant pesticides (paraquat and maneb) over 8weeks...
  93. ncbi Granulocyte macrophage-colony stimulating factor protects against substantia nigra dopaminergic cell loss in an environmental toxin model of Parkinson's disease
    E N Mangano
    Institute of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Neurobiol Dis 43:99-112. 2011
    ..macrophage colony stimulating factor (GM-CSF), would inhibit the neurodegenerative effects of the pesticide, paraquat, administered either alone or following priming with the bacterial endotoxin, lipopolysaccharide (LPS)...
  94. ncbi Chymase mediates paraquat-induced collagen production in human lung fibroblasts
    Yaw Dong Lang
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei 110, Taiwan
    Toxicol Lett 193:19-25. 2010
    Survivors of paraquat poisoning may be left with pulmonary fibrosis and a restrictive type of pulmonary dysfunction. Chymase converts angiotensin (Ang) I to Ang II, which is closely involved with lung fibrosis...
  95. ncbi Paraquat administration in Drosophila for use in metabolic studies of oxidative stress
    T Z Rzezniczak
    Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada P3E 2C6
    Anal Biochem 419:345-7. 2011
    b>Paraquat (PQ) is widely used in the laboratory to induce in vivo oxidative stress, particularly in the fruit fly, Drosophila melanogaster...
  96. pmc Genome-wide transcriptional and physiological responses of Bradyrhizobium japonicum to paraquat-mediated oxidative stress
    Andrew J Donati
    Department of Biology, University of Texas at Arlington, Life Science Building 216, Arlington, TX 76019, USA
    Appl Environ Microbiol 77:3633-43. 2011
    ..Therefore, B. japonicum must be able to resist such a defense mechanism to initiate nodulation. In this study, paraquat, a known superoxide radical-inducing agent, was used to investigate this response...
  97. ncbi The efficacy of high doses of vitamin C in patients with paraquat poisoning
    Jeong Mi Moon
    Department of Emergency Medicine, Chonnam National University Hospital, Gwangju, South Korea
    Hum Exp Toxicol 30:844-50. 2011
    b>Paraquat (PQ) poisoning is an extremely difficult condition to manage clinically because of the lack of effective treatments...
  98. pmc Comparison between kidney and hemoperfusion for paraquat elimination
    Moon Soo Kang
    Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea
    J Korean Med Sci 24:S156-60. 2009
    The mortality rate of acute paraquat (PQ) poisoning depends on the PQ concentration in the blood. It has been shown that the kidneys eliminate PQ effectively...
  99. ncbi Fatality in paraquat poisoning
    A M Sabzghabaee
    Isfahan Clinical Toxicology Research Centre, Noor and Ali Asghar General Teaching Hospital, Isfahan, Iran
    Singapore Med J 51:496-500. 2010
    Acute paraquat (PQ) poisoning continues to be a major public health concern in many developing countries...
  100. pmc Paraquat induces epigenetic changes by promoting histone acetylation in cell culture models of dopaminergic degeneration
    C Song
    Department of Biomedical Sciences, Iowa Center for Advanced Neurotoxicology, Iowa State University, Ames, IA 50011, USA
    Neurotoxicology 32:586-95. 2011
    ..The widely used herbicide paraquat is among the few environmental chemicals potentially linked with PD...
  101. ncbi Single high dose dexamethasone treatment decreases the pathological score and increases the survival rate of paraquat-intoxicated rats
    R J Dinis-Oliveira
    REQUIMTE, Departamento de Toxicologia, Faculdade de Farmacia, Universidade do Porto, Rua Anibal Cunha, 164, 4099 030 Porto, Portugal
    Toxicology 227:73-85. 2006
    Dexamethasone (DEX), a synthetic corticosteroid, has been successfully used in clinical practice during paraquat (PQ) poisonings due to its anti-inflammatory activity, although, as recently observed, its effects related to de novo ..

Research Grants63

  1. EFFECTS OF AGING ON GERMLINE AND SOMATIC STEM CELLS IN DROSOPHILA MELANOGASTER
    MATTHEW WALLENFANG; Fiscal Year: 2007
    ..of such damage by overexpressing superoxide dismutase in flies, and but increasing oxidative damage through paraquat treatment...
  2. Hematopoietic Stem Cells (HSCs) as Juvenile Protective Factors that Alter Aging
    David E Harrison; Fiscal Year: 2011
    ..will be exposed to treatments that cause genomic instability: gamma radiation, DNA polymerase inhibition, and paraquat. Genomic instability will be quantified as a) chromosome structural lesions (spectral karyotyping), b) segmental ..
  3. Oxidative stress and neurogenetic networks in Drosophila
    Robert R H Anholt; Fiscal Year: 2010
    ..background and environmental conditions can be precisely controlled, the response to oxidative stressors, such as paraquat, can be measured precisely, and a range of locomotor behaviors can be quantified accurately by simple assays as ..
  4. Organic Cation Transporter PMAT: Physiological Function and Role in Drug Disposit
    Joanne Wang; Fiscal Year: 2013
    ..and toxins (e.g. MPP+, paraquat) are hydrophilic organic cations (OCs) that do not readily cross cell membranes by passive diffusion...
  5. Identification of Mammalian Genes Promoting Life Extension
    SIU HUNG CHICK; Fiscal Year: 2013
    ..We screen for mutant ES cell clones that are resistant to paraquat and we screen these for multi-stress resistance, levels of reactive oxygen species under stress, pluripotency, ..
  6. Peroxiredoxin 6 and Cataractogenesis
    Dhirendra P Singh; Fiscal Year: 2010
    ..stress in vitro and in vivo using TAT-HA- PRDX6 to cargoing PRDX6 protein in Prdx6-/- depleted mice and mice with Paraquat-induced oxidative stress as well as Shumiya cataract rat (SCR), and assess whether cataract progression is slowed ..
  7. Astrocyte Control of Toxin-Mediated Neuron Death: Role of the Gamma-Glutamyl Path
    George I Henderson; Fiscal Year: 2010
    ..utilize cultures of neurons and astrocytes, alone and in co-culture, to address the direct impact of rotenone, paraquat, and E on astrocyte and neuron components of the ?-glutamyl cycle...
  8. Detoxification of Biogeneic Aldehydes in Parkinson's Disease
    Randy Strong; Fiscal Year: 2013
    ..Human and animal studies have established a link between environmental exposure to paraquat, maneb and rotenone in idiopathic or sporadic PD...
  9. Environmental toxins and stem cell epigenetic remodeling
    Joyce Ellen Ohm; Fiscal Year: 2013
    ..three specific aims are proposed: Specific Aim 1: Determine the in vitro WOS during which the environmental toxin paraquat induces DNA methylation changes in differentiating stem cells...
  10. Altered transport and epigenomic changes in maneb-potentiated neurotoxicity
    JAMES R ROEDE; Fiscal Year: 2012
    ..Specifically, exposures to the herbicide paraquat (PQ) and the fungicide maneb (MB) are associated with a 75-80% increased risk of PD...
  11. Mechanism of Peroxiredoxin 3 in a Model of Pesticide-Mediated Neurodegeneration
    JAMES R ROEDE; Fiscal Year: 2012
    ..Epidemiological investigations indicate exposure to the pesticides paraquat (PQ) and maneb (MB) increase the risk of PD, but the underlying mechanisms are unknown...
  12. Altered transport and epigenomic changes in maneb-potentiated neurotoxicity
    JAMES R ROEDE; Fiscal Year: 2013
    ..Specifically, exposures to the herbicide paraquat (PQ) and the fungicide maneb (MB) are associated with a 75-80% increased risk of PD...
  13. Oxidative modification of brain proteins in pesticide intoxication
    PIER MASTROBERARDINO; Fiscal Year: 2009
    ..identify those proteins that get oxidized following the administration of two different pesticides, rotenone or paraquat, and to validate their potential use as biomarkers in antioxidant therapy...
  14. Peroxiredoxin 6 as an Anti-oxidant Enzyme
    Aron B Fisher; Fiscal Year: 2013
    ..we have demonstrated that Prdx6 plays a seminal role in defense of lungs against oxidant stress (hyperoxia, paraquat), that the promoter of the gene contains an antioxidant response element that is sensitive to the transcription ..
  15. Pharmacogenomics of Parkinson's Disease
    Haydeh Payami; Fiscal Year: 2013
    ..will be performed: (1) a genome- wide gene-environment interaction study, (2) deficiency screening in the paraquat Drosophila model to identify loci that modify rescue by nicotine and caffeine, and testing the human homologues ..
  16. Pesticides and Parkinson's Disease
    Zhengui Xia; Fiscal Year: 2012
    ..have indicated a correlation between increased risk for PD and occupational exposure to pesticides including paraquat, a widely used herbicide...
  17. IGF-I Signaling and Aging
    Martin L Adamo; Fiscal Year: 2011
    ..IGF-I receptor gene in all tissues (Igflr^'mice) have extended life span in association with resistance to paraquat toxicity...
  18. Exposure to Pesticides: A Fetal Environmental Risk Factor for Parkinson's Disease
    BRIAN BARLOW; Fiscal Year: 2010
    ..mice, prenatal exposure to the fungicide maneb (MB) greatly increased adulthood susceptibility to the pesticide paraquat (PQ), resulting in features of PD...
  19. Mitochondrial ROS in environmental toxin-induced AD pathogenesis
    Qitao Ran; Fiscal Year: 2013
    ..We have recently showed that exposure to pesticide paraquat exacerbated cognitive impairment and increased A[unreadable] accumulation in AD animal models and that ..
  20. Dopamine, mutant synuclein, oxidative stress and inflammation
    Howard J Federoff; Fiscal Year: 2010
    ..Efforts to elucidate thls mechanism have been aided by the linkage between toxicant (e.g., MPTP, paraquat. rotenone) injury, oxidative stress, inherited defects in turnover of the presynaptic and Lewy Body constituent ..
  21. Aging Stress Pathway and Dopaminergic Neuron Degeneration in Parkinson's Disease
    Yong Chao Ma; Fiscal Year: 2013
    ..that induced by environmental toxicant 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and herbicide Paraquat, has been demonstrated to contribute to dopaminergic neuron degeneration in sporadic Parkinson's disease...
  22. Early life brain inflammation and vulnerability to neurodegeneration in late life
    Lir Wan Fan; Fiscal Year: 2013
    ..The following specific aims will be addressed: Aim 1: to investigate the effects of environmental toxin, paraquat, at an ordinarily non-toxic or sub-toxic dose, in order to characterize the chronic inflammatory conditions in ..
  23. Environmental Toxins and Genetic Factors in Parkinson Disease
    Xugang Xia; Fiscal Year: 2013
    ..In animal models, exposure to the environmental toxin paraquat causes permanent and accumulative damage to dopaminergic system...
  24. Pathogenic Mechanisms of Environmental Toxicants in Parkinson's Disease
    Lian Li; Fiscal Year: 2012
    ..Many of these toxicants, such as rotenone, paraquat, and 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine (MPTP), have been shown to increase the levels of reactive ..
  25. Mitochondrial mechanisms of redox cycling agents
    Manisha N Patel; Fiscal Year: 2013
    ..Redox cycling agents such as the herbicide paraquat (PQ2+) are found in the environment and several compounds in this class have come under investigation as ..
  26. Mitochondrial dynamics underlie gene-environment interactions in Parkinson's
    Adrianne Chesser; Fiscal Year: 2013
    ..In particular, the meperidine-derivative MPTP and the herbicide paraquat (PQ) have been linked to a long term risk of developing symptoms of PD...
  27. LRRK2 and Neurodegeneration
    Benjamin L Wolozin; Fiscal Year: 2013
    ..associated with increased protein misfolding and protection against mitochondrial toxins, such as rotenone and paraquat. Knockdown of lrk-1, the C. elegans homologue of LRRK2, has the opposite effects and renders C...
  28. Pesticide Interactions in LRRK2 Transgenic Models
    AMY BEATRICE MANNING BOG; Fiscal Year: 2010
    ..To test this hypothesis, we will administer paraquat or diethyldithiocarbamate, alone and in combination, to two lines of human LRRK2 transgenic mice (LRRK2 ..
  29. Protein radicals in microglia: environmental mechanisms of chronic neurotoxicity
    Michelle L Block; Fiscal Year: 2013
    ..Thus, beginning with the NF:2 p50 radical, we will test the specific hypothesis that paraquat, LPS, and MPTP/MPP+ cause microglial protein radicals that drive progressive neuroinflammation and DA ..
  30. Environmental toxin interactions with genetic risks for Parkinson's disease
    DAVID EVAN KRANTZ; Fiscal Year: 2011
    ..will therefore test the hypothesis that the neuroprotective effects of VMAT will extend to a different toxin, paraquat, thought to act by a different mechanism than rotenone, and whether this requires its localization to synaptic ..
  31. METABOLISM AND NUTRITION OF IRON AND OTHER TRACE METALS
    PAUL SALTMAN; Fiscal Year: 1993
    ..Strategies for preventing cellular damage in reperfused ischemic heart tissue and the toxic effects of paraquat in E. coli will be developed...
  32. LEUKOCYTE, ENZYME AND DRUG CHEMILUMINESCENCE STUDIES
    JEFFREY KANOFSKY; Fiscal Year: 1990
    ..carminic acid, mithramycin, chromomycin A3, olivomycin, mitomycin C, VP-16 streptonigrin, procarbazine, paraquat, cis-platinum and gossypol...
  33. Gene Environment Interactions in Parkinson's Disease
    Kim Tieu; Fiscal Year: 2010
    ..results, we hypothesize that PINK1 mutations increase cell susceptibility to environmental toxicants such as paraquat (PQ) through a novel mechanism: mitochondrial fragmentation via the mitochondrial fission / fusion machinery...
  34. Food Safety and Security Monitoring Project (U18), FERN Chemical Laboratories
    Shane A Wyatt; Fiscal Year: 2013
    ..LC/MS toxin screens to compounds that partition into the water phase, such as the contact herbicides diquat and paraquat. The analysis of melamine and its analogs will also be evaluated by LC/MS with automated Solid Phase Extraction (..
  35. FREE RADICALS, PROTEIN AGGREGATES & PARKINSON'S DISEASE
    GARY PIELAK; Fiscal Year: 2001
    ..Exposure to the herbicide paraquat is associated with an increased risk of Parkinson's Disease...
  36. 7 FE FDI AS A MODEL FE-S AND REGULATORY PROTEIN
    Thomas Poulos; Fiscal Year: 2002
    ..FdI has a regulatory function related to an oxidative stress system that responds to the superoxide propagater paraquat. We have shown that FdI controls the expression of its redox partner NADPH:ferredoxin reductase indirectly ..
  37. OXIDANT MECHANISMS IN DRUG-INDUCED HEPATIC NECROSIS
    Charles Smith; Fiscal Year: 2006
    ..Therapeutic uses of acetaminophen and furosemide are extensive, and diquat and paraquat are widely used herbicides...
  38. Developmental Pesticide Exposure: The Parkinson's Disease Phenotype
    Mona Thiruchelvam; Fiscal Year: 2010
    ..Combined exposure from postnatal day (PND) 7-19 to the pesticides paraquat(PQ) + maneb (MB) produces permanent and selective nigrostriatal DA neurotoxicity, and markedly enhances ..
  39. Environmental Toxicants and Neurodegeneration
    Kim Tieu; Fiscal Year: 2010
    ..Based on our preliminary data we hypothesize that cations such as MPP+ (1-methyl-4-phenylpyridinium) and paraquat (PQ) are bi- directionally transported across the astrocytic plasma membrane by the organic cation transporter 3 (..
  40. MIMICS OF SUPEROXIDE DISMUTASE--ISOLATION & SYNTHESIS
    Irwin Fridovich; Fiscal Year: 1990
    ..test whether these SOD mimics decrease the inductions of SOD in Escherichia coli which are caused by oxygenand by paraquat. These studies will then be extended to cultured mammalian cells...
  41. Genetic Model of Caloric Restriction
    Blanka Rogina; Fiscal Year: 2002
    ..changes in the metabolism of ROS, they will determine the resistance of Indy flies to temperature, starvation, paraquat and hyperoxia...
  42. 1-Cys-peroxiredoxin, A Novel Lung Anti-oxidant Enzyme
    Aron Fisher; Fiscal Year: 2004
    ..Cell lines that overexpress 1-cysPrx will be generated and evaluated for resistance to oxidative stress (H2O2, paraquat)...
  43. VITAMIN E TURNOVER AND CHEMICAL TOXICITY
    DANIEL LIEBLER; Fiscal Year: 1992
    ..Membrane fractions will be challenged with toxic chemicals known to induce free radical injury including paraquat, methyl ethyl ketone peroxide, doxorubicin, and tertbutyl hydroperoxide...
  44. TOXICITY OF O2- AND H2O2
    Robert Lynch; Fiscal Year: 1993
    ..In one prototype of toxicity fostered by the reduction of molecular oxygen, the various cytotoxic actions of paraquat, mutagenicity and malignant transformation were observed but whether either of these was due O2-, H2O2, or OH was ..
  45. NEUROPATHOLOGY OF THE AGING SYMPATHETIC NERVOUS SYSTEM
    Robert Schmidt; Fiscal Year: 2006
    ..Since our last submission, we have discovered that suicidal ingestion of paraquat (PQ), a superoxide-generating herbicide, results in autonomic failure and the development of NAD in human ..
  46. COMBINED AGRICHEMICAL EXPOSURES AND PARKINSON'S DISEASE
    Deborah Cory Slechta; Fiscal Year: 2004
    ..Efforts to confirm an involvement of the herbicide paraquat, a compound with structural similarity to the DA neurotoxicant, MPTP that produces a PD-like syndrome in humans, ..
  47. BIOMEDICAL RESEARCH SUPPORT
    PAUL HOCHSTEIN; Fiscal Year: 1991
    ..the role of leucocyte activation in this process; B) the involvement of oxygen free radicals in the metabolism of paraquat; C) the role of free radical intermediates in ethanol cocaine, chlorohydrocarbon anesthetics, and aromatic amine ..
  48. EPIDEMIOLOGY OF PARKINSONS DISEASE AND FARM RISK FACTORS
    Daniel Strickland; Fiscal Year: 1999
    ..potential confounding or because some agricultural exposures may have been overlooked as a result of the focus on paraquat chemicals...
  49. Mitochondrial Response to Oxidative Stress
    DANIEL BOGENHAGEN; Fiscal Year: 2006
    ..A number of cellular toxins, including rotenone, 1-methyl-4-phenylpyridine (MPP+) and paraquat act to impair mitochondrial electron transport, generating ROS...
  50. Xenobiotics, Lipid Peroxidation and Autoimmunity
    M Firoze Khan; Fiscal Year: 2006
    ..MRL+/+) and -resistant (B6C3F1) mice treated with environmental chemicals (trichloroethene and paraquat) known to cause lipid peroxidation; 2) To establish a link between increased LPDAs and the development of ..
  51. COLLAGEN METABOLISM IN RAT LUNG EXPLANTS
    Deborah Greenberg; Fiscal Year: 1980
    The ability of ozone, paraquat, and high levels of oxygen to induce pulmonary fibrosis in rats will be tested...
  52. ENVIRONMENTAL NEUROTOXICANT GENETIC ACTION--MURINE MODEL
    Howard Federoff; Fiscal Year: 2002
    ..Vulnerability to systemically administered neurotoxicants MPTP and paraquat will be examined in mice in which a subset of nigral dopaminergic neurons have increased DAT expression...
  53. PESTICIDE-SYNUCLEIN: RISK FACTORS FOR PARKINSON'S
    Satinder Sarang; Fiscal Year: 2004
    ..exposure and PD, and pesticides that cause oxidative stress and mitochondrial dysfunction, such as rotenone and paraquat, are used in cellular and animal models of PD...
  54. Genetic Susceptibility Loci in Mouse Neurotoxic Parkins*
    Eric Richfield; Fiscal Year: 2003
    ..nigra pars compacta (SNpc) neuron number in 15 inbred strains of mice treated with saline or with MPTP, paraquat, or paraquat plus maneb...
  55. CHEMICAL INTERACTIONS AND OXIDATIVE STRESS IN FISH
    A Steward; Fiscal Year: 1992
    ..stress induced by TCDD in rainbow trout in vivo; use these markers to assess the potential of the pesticides paraquat and diclone to produce oxidative stress, both alone and in combination with TCDD; and statistically assess the ..
  56. GOLGI APPARATUS IN AMYOTROPHIC LATERAL SCLEROSIS
    NICHOLAS GONATAS; Fiscal Year: 2001
    ..parallel experiments the GA will be investigated in cells expressing G93A after oxidative stress induced by H202, paraquat and peroxynitrite...
  57. Role of Msr in Oxidative Stres in S. aureus
    RADHESHYAM JAYASWAL; Fiscal Year: 2002
    ..the msrA mutants will be tested for oxidative stress tolerance against various oxidative agents, such as H2O2, paraquat, AAPH...
  58. RADIATION BIOCHEMISTRY OF DNA BASE DAMAGE
    H Claycamp; Fiscal Year: 1991
    ..radiolysis products, O2- and H2O2, on cellular DNA damage without exogenous chemical modifiers such as H2O2 or paraquat. Procedures for the measurement of DNA base damage in cells and in model DNA that have been developed in previous ..
  59. TOXIC EFFECTS OF PARAQUAT AND DIQUAT ON LUNG METABOLISM
    Miguel Medina; Fiscal Year: 1980
    The technique of microwave inactivation of tissue will be used to study the in vivo effects of paraquat and diquat on labile metabolites in mouse lung...
  60. RAPID CHEMILUMINESCENT SCREEN TEST FOR MICROORGANISMS
    ROBERT CARRICO; Fiscal Year: 1992
    ..The work will use lucigenin and luminol as chemiluminescent probes and will use redox active agents, such as paraquat, to transfer reducing equivalents from enzymes and cofactors to oxygen and the chemiluminescent probes...
  61. Modulation of Lung Inflammation and Cell Death by VIP
    SAMI SAID; Fiscal Year: 2006
    ..and is uniquely suited to a critical analysis of cell death mechanisms in lung injury; b) oxidant injury due to paraquat and xanthine + xanthine oxidase; and c) endotoxin lipopolysaccharide (LPS)-and Fas- induced apoptotic cell death...
  62. BIOLOGICAL SUPEROXIDE RADICAL MECHANISMS
    BENON BIELSKI; Fiscal Year: 1992
    ..Evidence is accumulating that links such events to paraquat, halogen and anti-cancer drug toxicity, arthritis, tissue damage following reperfusion, dementia etc...
  63. Natural Genetic Variation and Epistasis in Aging
    Daniel Promislow; Fiscal Year: 2002
    ..background, we will measure the effect of mutants on age-specific mortality, resistance to oxidative stress (paraquat) and resistance to heat shock...