pyridoxine

Summary

Summary: The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).

Top Publications

  1. ncbi Pyridoxine-responsive seizures as the first symptom of infantile hypophosphatasia caused by two novel missense mutations (c.677T>C, p.M226T; c.1112C>T, p.T371I) of the tissue-nonspecific alkaline phosphatase gene
    Sara Baumgartner-Sigl
    Department of Pediatrics, Medical University Innsbruck, Austria
    Bone 40:1655-61. 2007
  2. ncbi Vitamin B6 (pyridoxine) and its derivatives are efficient singlet oxygen quenchers and potential fungal antioxidants
    P Bilski
    Laboratory of Pharmacology and Chemistry, NIEHS Environmental Toxicology Program, Research Triangle Park, NC 27709, USA
    Photochem Photobiol 71:129-34. 2000
  3. pmc Genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy (ALDH7A1 deficiency)
    Philippa B Mills
    Institute of Child Health, University College London with Great Ormond Street Hospital for Children, National Health Service Trust, London, UK
    Brain 133:2148-59. 2010
  4. pmc Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy
    TracyAnn Perry
    Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Room 2C13, Gerontology Research Center, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    Exp Neurol 203:293-301. 2007
  5. pmc The genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy due to mutations in ALDH7A1
    Gunter Scharer
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    J Inherit Metab Dis 33:571-81. 2010
  6. ncbi Characterization of endoperoxide and hydroperoxide intermediates in the reaction of pyridoxine with singlet oxygen
    Brian K Ohta
    Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095 1569, USA
    J Am Chem Soc 124:12064-5. 2002
  7. ncbi Update on interconversions of vitamin B-6 with its coenzyme
    D B McCormick
    Department of Biochemistry, Rollins Research Center, Emory University, Atlanta, GA 30322 3050, USA
    J Nutr 129:325-7. 1999
  8. ncbi Implications of genotype and enzyme phenotype in pyridoxine response of patients with type I primary hyperoxaluria
    Carla G Monico
    Mayo Clinic Hyperoxaluria Center, Division of Pediatric Nephrology, Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Am J Nephrol 25:183-8. 2005
  9. ncbi Evaluation of the effect of triterpenes on urinary risk factors of stone formation in pyridoxine deficient hyperoxaluric rats
    Lakshminarasimhan Vidya
    Department of Medical Biochemistry, Dr A L M Post Graduate Institute of Basic Medical Sciences, Taramani, Chennai 600 113, India
    Phytother Res 16:514-8. 2002
  10. ncbi Ginkgo biloba and ginkgotoxin
    Eckhard Leistner
    Institut for Pharmazeutische Biologie der Rheinischen Friedrich Wilhelms Universität Bonn, Nussallee 6, D 53115 Bonn, Germany
    J Nat Prod 73:86-92. 2010

Detail Information

Publications304 found, 100 shown here

  1. ncbi Pyridoxine-responsive seizures as the first symptom of infantile hypophosphatasia caused by two novel missense mutations (c.677T>C, p.M226T; c.1112C>T, p.T371I) of the tissue-nonspecific alkaline phosphatase gene
    Sara Baumgartner-Sigl
    Department of Pediatrics, Medical University Innsbruck, Austria
    Bone 40:1655-61. 2007
    b>Pyridoxine-responsive seizures (PRS) and the role of pyridoxine (PN, vitamin B(6)) in hypophosphatasia (HPP) are incompletely understood. Typically, PRS and HPP are rare, independent, metabolic disorders...
  2. ncbi Vitamin B6 (pyridoxine) and its derivatives are efficient singlet oxygen quenchers and potential fungal antioxidants
    P Bilski
    Laboratory of Pharmacology and Chemistry, NIEHS Environmental Toxicology Program, Research Triangle Park, NC 27709, USA
    Photochem Photobiol 71:129-34. 2000
    Vitamin B6 (pyridoxine, 1) and its derivatives: pyridoxal (2), pyridoxal 5-phosphate (3) and pyridoxamine (4) are important natural compounds involved in numerous biological functions...
  3. pmc Genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy (ALDH7A1 deficiency)
    Philippa B Mills
    Institute of Child Health, University College London with Great Ormond Street Hospital for Children, National Health Service Trust, London, UK
    Brain 133:2148-59. 2010
    b>Pyridoxine-dependent epilepsy was recently shown to be due to mutations in the ALDH7A1 gene, which encodes antiquitin, an enzyme that catalyses the nicotinamide adenine dinucleotide-dependent dehydrogenation of l-alpha-aminoadipic ..
  4. pmc Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy
    TracyAnn Perry
    Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Room 2C13, Gerontology Research Center, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    Exp Neurol 203:293-301. 2007
    b>Pyridoxine (vitamin B6) intoxicated rodents develop a peripheral neuropathy characterized by sensory nerve conduction deficits associated with disturbances of nerve fiber geometry and axonal atrophy...
  5. pmc The genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy due to mutations in ALDH7A1
    Gunter Scharer
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    J Inherit Metab Dis 33:571-81. 2010
    b>Pyridoxine-dependent epilepsy is a disorder associated with severe seizures that may be caused by deficient activity of α-aminoadipic semialdehyde dehydrogenase, encoded by the ALDH7A1 gene, with accumulation of α-aminoadipic ..
  6. ncbi Characterization of endoperoxide and hydroperoxide intermediates in the reaction of pyridoxine with singlet oxygen
    Brian K Ohta
    Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095 1569, USA
    J Am Chem Soc 124:12064-5. 2002
    The photosensitized oxidation of vitamin B6, pyridoxine, is investigated by product and kinetic analysis...
  7. ncbi Update on interconversions of vitamin B-6 with its coenzyme
    D B McCormick
    Department of Biochemistry, Rollins Research Center, Emory University, Atlanta, GA 30322 3050, USA
    J Nutr 129:325-7. 1999
    ..pyridoxal (pyridoxine, pyridoxamine) kinase and pyridoxine (pyridoxamine) phosphate oxidase...
  8. ncbi Implications of genotype and enzyme phenotype in pyridoxine response of patients with type I primary hyperoxaluria
    Carla G Monico
    Mayo Clinic Hyperoxaluria Center, Division of Pediatric Nephrology, Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Am J Nephrol 25:183-8. 2005
    ..Approximately half of PHI patients experience improvement in the degree of hyperoxaluria following pyridoxine (VB6) treatment...
  9. ncbi Evaluation of the effect of triterpenes on urinary risk factors of stone formation in pyridoxine deficient hyperoxaluric rats
    Lakshminarasimhan Vidya
    Department of Medical Biochemistry, Dr A L M Post Graduate Institute of Basic Medical Sciences, Taramani, Chennai 600 113, India
    Phytother Res 16:514-8. 2002
    ..Administration of a pyridoxine deficient diet containing 3% glycollic acid for 21 days led to increased excretion of stone forming constituents ..
  10. ncbi Ginkgo biloba and ginkgotoxin
    Eckhard Leistner
    Institut for Pharmazeutische Biologie der Rheinischen Friedrich Wilhelms Universität Bonn, Nussallee 6, D 53115 Bonn, Germany
    J Nat Prod 73:86-92. 2010
    ..biloba products. The present paper summarizes recent experiences with G. biloba and its derived products and explains why their restricted use is recommended...
  11. ncbi The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba
    Uta Kästner
    Institut fur Pharmazeutische Biologie, Universitat Bonn, Germany
    FEBS J 274:1036-45. 2007
    ..serves as an alternate substrate for this enzyme with a lower K(m) value than pyridoxal, pyridoxamine or pyridoxine. Thus, the presence of ginkgotoxin leads to temporarily reduced pyridoxal phosphate formation in vitro and ..
  12. ncbi Hexamethylmelamine and low or moderate dose cisplatin with or without pyridoxine for treatment of advanced ovarian carcinoma: a study of the Eastern Cooperative Oncology Group
    P H Wiernik
    Albert Einstein Cancer Center, Bronx, New York
    Cancer Invest 10:1-9. 1992
    ..v. on Day 1 at a dose of 37.5 mg/m2 (regimens A and B) or 75 mg/m2 (regimens C and D). In addition, since pyridoxine administration has been reported to reduce the neurotoxicity of HMM, that agent was given at a dose of 300 mg/m2 ..
  13. ncbi Pyridoxine effect in type I primary hyperoxaluria is associated with the most common mutant allele
    Carla G Monico
    Mayo Clinic College of Medicine, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
    Kidney Int 67:1704-9. 2005
    b>Pyridoxine (VB6) response in type I primary hyperoxaluria (PHI) is variable, with nearly equal numbers of patients showing partial to complete reductions in oxaluria, and resistance...
  14. ncbi Pyridoxine is not effective to prevent hand-foot syndrome associated with capecitabine therapy: results of a randomized, double-blind, placebo-controlled study
    Yoon Koo Kang
    Department of Oncology, University of Ulsan College of Medicine, Asan Medical Center, Songpa Gu, Seoul, 138 736 Korea
    J Clin Oncol 28:3824-9. 2010
    To determine whether concurrent pyridoxine therapy can prevent the development of hand-foot syndrome (HFS) in patients being treated with capecitabine.
  15. ncbi B6-responsive disorders: a model of vitamin dependency
    Peter T Clayton
    Biochemistry, Endocrinology and Metabolism, Institute of Child Health, 30 Guilford St, London, WC1N 1 EH, UK
    J Inherit Metab Dis 29:317-26. 2006
    ..There are several different mechanisms that lead to an increased requirement for pyridoxine and/or pyridoxal phosphate...
  16. pmc Pyridoxine biosynthesis in yeast: participation of ribose 5-phosphate ketol-isomerase
    Hiroki Kondo
    Department of Biochemical Engineering and Science, Kyushu Institute of Technology, Kawazu 680 4, Iizuka 820 8502, Japan
    Biochem J 379:65-70. 2004
    To identify the genes involved in pyridoxine synthesis in yeast, auxotrophic mutants were prepared...
  17. ncbi PNPO deficiency: an under diagnosed inborn error of pyridoxine metabolism
    Morad Khayat
    Institute of Medical Genetics, Western Galilee Hospital, Nahariya, P O Box 21, 22100 Nahariya, Israel
    Mol Genet Metab 94:431-4. 2008
    The rare autosomal recessive disorder pyridoxine 5'-phosphate oxidase (PNPO) deficiency is a recently described cause of neonatal and infantile seizures...
  18. ncbi Dose-dependent effects of glutamate in pyridoxine-induced neuropathy
    Tarinee Arkaravichien
    Faculty of Medicine, Khon Kaen University, 40002 Khon Kaen, Thailand
    Food Chem Toxicol 41:1375-80. 2003
    In order to explore the effects of glutamate in a pyridoxine megadose-induced neuropathy, rats were received glutamate either 0.5 or 1 g/kg/day orally with or without pyridoxine 0.8 g/kg/day intraperitoneally for 14 days...
  19. ncbi Pyridoxine to protect from oxaliplatin-induced neurotoxicity without compromising antitumour effect
    Madhu B Garg
    Department of Medical Oncology, Calvary Mater Newcastle Hospital, Locked Bag No 7, Hunter Regional Mail Centre, Newcastle, NSW 2310, Australia
    Cancer Chemother Pharmacol 67:963-6. 2011
    ..Reversible, cumulative, peripheral sensory neuropathy is the principal dose-limiting toxicity of OHP therapy. Pyridoxine (vitamin B6) has been shown to reduce cisplatin and fluoropyrimidine-related neurotoxicity but its ..
  20. ncbi Phylogenetic analyses and comparative genomics of vitamin B6 (pyridoxine) and pyridoxal phosphate biosynthesis pathways
    G Mittenhuber
    Institut fur Mikrobiologie und Molekularbiologie, Ernst Moritz Arndt Universitat, Greifswald, Germany
    J Mol Microbiol Biotechnol 3:1-20. 2001
    ..This proposal might help to explain why the PdxA/PdxJ pathway is largely restricted to this subdivision...
  21. ncbi Combination effects of sodium butyrate and pyridoxine treatment on cell proliferation and neuroblast differentiation in the dentate gyrus of D-galactose-induced aging model mice
    Dae Young Yoo
    Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul 151 742, South Korea
    Neurochem Res 37:223-31. 2012
    We previously reported that sodium butyrate (SB), a histone deacetylase inhibitor, robustly increased pyridoxine-induced cell proliferation and neuroblast differentiation in the dentate gyrus of the adult mouse...
  22. ncbi S250F variant associated with aromatic amino acid decarboxylase deficiency: molecular defects and intracellular rescue by pyridoxine
    Riccardo Montioli
    Department of Life Sciences and Reproduction, University of Verona, Verona, Italy
    Hum Mol Genet 22:1615-24. 2013
    ..Importantly, 4-phenylbutirric acid (4-PBA) or, to a major extent, pyridoxine increase the expression level and, in a dose-dependent manner, the decarboxylase specific activity of mutant-..
  23. ncbi Transport of high concentration of thiamin, riboflavin and pyridoxine across intestinal epithelial cells Caco-2
    Magdalena Zielińska-Dawidziak
    Department of Biotechnology and Food Microbiology, University of Life Sciences in Poznan
    J Nutr Sci Vitaminol (Tokyo) 54:423-9. 2008
    In this study, we examined the intestinal uptake of thiamin (vitamin B(1)), riboflavin (vitamin B(2)) and pyridoxine (vitamin B(6)) administered at high concentration using intestinal epithelial Caco-2 cells as an in vitro model of drugs ..
  24. ncbi Ginkgo seed poisoning
    Yo Kajiyama
    Department of Pediatrics Kyoto Min i ren Central Hospital Kyoto, Japan
    Pediatrics 109:325-7. 2002
    ..Awareness of the potential danger of overconsumption of this traditional food and its prompt treatment with pyridoxal phosphate may hasten recovery...
  25. pmc Beta-glucosidase, exo-beta-glucanase and pyridoxine transglucosylase activities of rice BGlu1
    Rodjana Opassiri
    Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
    Biochem J 379:125-31. 2004
    ..b>Pyridoxine 5'-O-beta-D-glucoside was the most efficiently hydrolysed natural glycoside tested...
  26. ncbi Pyridoxine uptake by colonocytes: a specific and regulated carrier-mediated process
    Zainab M Said
    Department of Medicine and Physiology, University of California, Irvine, California, USA
    Am J Physiol Cell Physiol 294:C1192-7. 2008
    The water-soluble vitamin B6 (pyridoxine) is important for normal cellular functions, growth, and development...
  27. pmc An Escherichia coli K-12 tktA tktB mutant deficient in transketolase activity requires pyridoxine (vitamin B6) as well as the aromatic amino acids and vitamins for growth
    G Zhao
    Department of Microbiology and Molecular Genetics, University of Texas Houston Medical School, Houston 77030 1501
    J Bacteriol 176:6134-8. 1994
    ..tktB double mutant, which is devoid of the two known transketolase isoenzymes of Escherichia coli K-12, requires pyridoxine (vitamin B6) as well as the aromatic amino acids and vitamins for growth...
  28. pmc Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women's Antioxidant and Folic Acid Cardiovascular Study
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue E, Boston, MA 02215 1204, USA
    Arch Intern Med 169:335-41. 2009
    ..Our objective was to examine the incidence of AMD in a trial of combined folic acid, pyridoxine hydrochloride (vitamin B(6)), and cyanocobalamin (vitamin B(12)) therapy.
  29. ncbi Effect of high-dose thiamine and pyridoxine on advanced glycation end products and other oxidative stress markers in hemodialysis patients: a randomized placebo-controlled study
    Marcelo M Nascimento
    Faculdade Evangélica do Paraná Brazil, Parana, Brazil
    J Ren Nutr 16:119-24. 2006
    To study the effect of high doses of thiamine (250 mg/day) and pyridoxine (200 mg/day) supplementation on plasma levels of advanced glycation end products and other oxidative stress markers in hemodialysis patients.
  30. ncbi Effects of combined lipoic acid and pyridoxine on albuminuria, advanced glycation end-products, and blood pressure in diabetic nephropathy
    Nazanin Noori
    Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Int J Vitam Nutr Res 83:77-85. 2013
    This study was designed to investigate the effects of combined administration of lipoic acid and pyridoxine on albuminuria, oxidative stress, blood pressure, serum advanced glycation end-products, nitric oxide (NO), and endothelin-1 in ..
  31. pmc Comparative study of the effects of pyridoxine, rifampin, and renal function on hematological adverse events induced by linezolid
    Alex Soriano
    Department of Infectious Diseases, Hospital Clinic of Barcelona, C Villarroel 170, Barcelona 08036, Spain
    Antimicrob Agents Chemother 51:2559-63. 2007
    ..The aim of this study was to evaluate the influences of pyridoxine, rifampin, and renal function on hematological adverse events...
  32. ncbi Folinic acid-responsive seizures are identical to pyridoxine-dependent epilepsy
    Renata C Gallagher
    Clinical Genetics and Metabolism, Department of Pediatrics, University of Colorado at Denver, CO, USA
    Ann Neurol 65:550-6. 2009
    Folinic acid-responsive seizures and pyridoxine-dependent epilepsy are two treatable causes of neonatal epileptic encephalopathy...
  33. pmc Epidemiology of pyridoxine dependent and pyridoxine responsive seizures in the UK
    P Baxter
    Ryegate Centre, Sheffield Children s Hospital, Tapton Crescent, Sheffield S10 5DD, UK
    Arch Dis Child 81:431-3. 1999
    To study the epidemiology of pyridoxine dependent seizures and other forms of pyridoxine responsive seizures.
  34. ncbi Prevalence of ALDH7A1 mutations in 18 North American pyridoxine-dependent seizure (PDS) patients
    Craig L Bennett
    Division of Genetics and Developmental Medicine, Department of Pediatrics, University of Washington, and Children s Hospital and Regional Medical Center, Seattle, Washington 98195 6320, USA
    Epilepsia 50:1167-75. 2009
    b>Pyridoxine-dependent seizure (PDS) is a rare disorder characterized by seizures that are resistant to common anticonvulsants, and that are ultimately controlled by daily pharmacologic doses of pyridoxine (vitamin B6)...
  35. pmc Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy
    H S Wang
    Division of Pediatric Neurology, Chang Gung Children s Hospital, and Medical College of Chang Gung University, Taoyuan, Taiwan
    Arch Dis Child 90:512-5. 2005
    To study the difference between pyridoxine (PN) and its active form, pyridoxal phosphate, (PLP) in control of idiopathic intractable epilepsy in children.
  36. ncbi Current knowledge concerning optimum nutritional status of riboflavin, niacin and pyridoxine
    H J Powers
    Division of Child Health, University of Sheffield, Sheffield Children s Hospital, UK
    Proc Nutr Soc 58:435-40. 1999
    ..The present short review considers the current position regarding such markers for riboflavin, pyridoxine and niacin...
  37. ncbi Homocysteine, fibrinogen, and lipoprotein(a) levels are simultaneously reduced in patients with chronic renal failure treated with folic acid, pyridoxine, and cyanocobalamin
    M Naruszewicz
    Regional Center for Atherosclerosis Research, Pomeranian Academy of Medicine, and the Dialysis Unit of the Provincial Hospital, Szczecin, Poland
    Metabolism 50:131-4. 2001
    ..Folic acid (15 mg/d), pyridoxine (150 mg/d), and cyanocobalamin (1 mg/wk) were administered for 4 weeks in 21 patients receiving dialysis, and a ..
  38. pmc A gene for pyridoxine-dependent epilepsy maps to chromosome 5q31
    V Cormier-Daire
    Department of Medical Genetics and INSERM U393, Hopital Necker Enfants Malades, 75015 Paris, France
    Am J Hum Genet 67:991-3. 2000
    b>Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive disorder characterized by generalized seizures in the first hours of life and responding only to pyridoxine hydrochloride...
  39. pmc Epidemiology of pyridoxine dependent seizures in the Netherlands
    J V Been
    Department of Paediatrics, Maastricht University Hospital, Netherlands
    Arch Dis Child 90:1293-6. 2005
    b>Pyridoxine dependent epilepsy is a rare cause of seizures in childhood. The diagnosis is made on clinical criteria, that in many cases are never met. Therefore, epidemiological data on pyridoxine dependency are scarce.
  40. pmc Alterations in hippocampal serotonergic and INSR function in streptozotocin induced diabetic rats exposed to stress: neuroprotective role of pyridoxine and Aegle marmelose
    Pretty Mary Abraham
    Molecular Neurobiology and Cell Biology Unit, Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, Cochin 682 022, Kerala, India
    J Biomed Sci 17:78. 2010
    ..The present study was carried out to find the effects of insulin, Aegle marmelose alone and in combination with pyridoxine on the hippocampal 5-HT, 5-HT(2A) receptor subtype, gene expression studies on 5-HT(2A), 5-HTT, INSR, ..
  41. ncbi Thiamine, riboflavin, pyridoxine, and vitamin C status in premature infants receiving parenteral and enteral nutrition
    J K Friel
    Department of Biochemistry, Memorial University of Newfoundland, St John s, Newfoundland A1B 3X9, Canada
    J Pediatr Gastroenterol Nutr 33:64-9. 2001
    ..There is a paucity of data about water soluble vitamin status in low birthweight infants. Therefore, the authors' objective was to assess current feeding protocols...
  42. ncbi Electroencephalographic changes in pyridoxine-dependant epilepsy: new observations
    Georges Naasan
    Department of Pediatrics, American University of Beirut, Medical Center, Beirut, Lebanon
    Epileptic Disord 11:293-300. 2009
    b>Pyridoxine-dependent epilepsy (PDE) is a rare disease, of which the EEG manifestations are only partially characterised. We report our observations of EEG recordings in four patients with PDE.
  43. ncbi Multiple mechanisms of action of pyridoxine in primary hyperoxaluria type 1
    Sonia Fargue
    Department of Cell and Developmental Biology, University College London, London, UK
    Biochim Biophys Acta 1832:1776-83. 2013
    ..About one third of patients are responsive to pharmacological doses of pyridoxine (vitamin B6), but its mechanism of action is unknown...
  44. ncbi Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin)
    Simerpal Kaur Gill
    The Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ther Drug Monit 33:115-9. 2011
    Diclectin, composed of 10 mg doxylamine succinate (DOX) and 10 mg pyridoxine hydrochloride, is the drug combination of choice for the management of nausea and vomiting during pregnancy in Canada...
  45. ncbi Polyneuropathy, anti-tuberculosis treatment and the role of pyridoxine in the HIV/AIDS era: a systematic review
    J J Van der Watt
    Division of Neurology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Int J Tuberc Lung Dis 15:722-8. 2011
    ..the development of a painful isoniazid (INH) associated polyneuropathy (PN), which is preventable with adequate pyridoxine supplementation...
  46. ncbi Effects of dietary pyridoxine on haemato-immunological responses of Labeo rohita fingerlings reared at higher water temperature
    M S Akhtar
    Division of Fish Nutrition, Biochemistry and Physiology, Central Institute of Fisheries Education, Versova, Mumbai, India
    J Anim Physiol Anim Nutr (Berl) 96:581-90. 2012
    A sixty-day feeding trial was carried out to elucidate the effect of dietary pyridoxine (PN) on hemato-immunological parameters in Labeo rohita fingerlings exposed to an elevated temperature (ET) of 33 °C...
  47. ncbi Association of plasma B-6 vitamers with systemic markers of inflammation before and after pyridoxine treatment in patients with stable angina pectoris
    Arve Ulvik
    Bevital A S, Laboratoriebygget, Bergen, Norway
    Am J Clin Nutr 95:1072-8. 2012
    ..A negative association between systemic markers of inflammation and plasma vitamin B-6 has been observed in population-based and patient cohorts; however, vitamin B-6 (pyridoxine) treatment has mostly failed to improve inflammatory indexes.
  48. ncbi Pyridoxine-dependent seizures: long-term follow-up of two cases with clinical and MRI findings, and pyridoxine treatment
    Hizir Ulvi
    Firat University Medical Faculty, Department of Neurology, Elazig, Turkey
    J Trop Pediatr 48:303-6. 2002
    b>Pyridoxine-dependency is a rare autosomal recessive disorder causing a severe seizure disorder of neonatal onset...
  49. pmc Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy
    Maged M Costantine
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, USA
    Ther Drug Monit 34:569-73. 2012
    ..The authors' objective is to identify the determinants of adherence to delayed-release doxylamine-pyridoxine (Diclectin) in patients with nausea and vomiting of pregnancy (NVP).
  50. ncbi Comparing the pharmacokinetics of doxylamine/pyridoxine delayed-release combination in nonpregnant women of reproductive age and women in the first trimester of pregnancy
    Ilan Matok
    University of Toronto, Toronto, Ontario, Canada
    J Clin Pharmacol 53:334-8. 2013
    Although Diclectin (doxylamine/pyridoxine delayed-released combination) is widely used in Canada, its pharmacokinetics (PK) during pregnancy has never been described...
  51. ncbi Pyridoxine restores endothelial cell function in high glucose
    Bret G Kelso
    School of Biological and Health Systems Engineering, Fulton Schools of Engineering, Arizona State University, Tempe, Arizona 85287 9709, USA
    Metab Syndr Relat Disord 9:63-8. 2011
    ..This study tests whether aminoguanidine can also restore migratory ability of endothelial cells and whether pyridoxine, a stable form of vitamin B6, can restore migratory ability and ability to align and elongate in response to ..
  52. ncbi The EEG response to pyridoxine-IV neither identifies nor excludes pyridoxine-dependent epilepsy
    Levinus A Bok
    Department of Pediatrics, Maxima Medical Center, Veldhoven, The Netherlands
    Epilepsia 51:2406-11. 2010
    b>Pyridoxine-dependent epilepsy (PDE) is characterized by therapy-resistant seizures (TRS) responding to intravenous (IV) pyridoxine...
  53. pmc The effect of a subnormal vitamin B-6 status on homocysteine metabolism
    J B Ubbink
    Department of Chemistry Pathology, University of Pretoria, South Africa
    J Clin Invest 98:177-84. 1996
    ..01) reduced in both groups after vitamin supplementation. It is concluded that a vitamin B-6 deficiency may contribute to impaired transsulfuration and an abnormal methionine load test, which is associated with premature vascular disease...
  54. ncbi Pyridoxine-induced toxicity in rats: a stereological quantification of the sensory neuropathy
    Tracy Ann Perry
    Section of Drug Design and Development, Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Exp Neurol 190:133-44. 2004
    Excess ingestion of pyridoxine (vitamin B6) causes a severe sensory neuropathy in humans. The mechanism of action has not been fully elucidated, and studies of pyridoxine neuropathy in experimental animals have yielded disparate results...
  55. ncbi Pyridoxine (vitamin B6) neurotoxicity: enhancement by protein-deficient diet
    Seymour Levine
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    J Appl Toxicol 24:497-500. 2004
    Large doses of pyridoxine cause injury to the primary sensory neurons in trigeminal and dorsal root ganglia of animals and patients subjected to megavitamin therapy...
  56. ncbi Pyridoxine inhibits depolarization-evoked glutamate release in nerve terminals from rat cerebral cortex: a possible neuroprotective mechanism?
    Tsung Tair Yang
    Department of Psychiatry, Cardinal Tien Hospital, Taipei, Taiwan
    J Pharmacol Exp Ther 331:244-54. 2009
    b>Pyridoxine (vitamin B(6)) protects neurons against neurotoxicity. An excessive release of glutamate is widely considered to be one of the molecular mechanisms of neuronal damage in several neurological diseases...
  57. pmc Amiloride uptake and toxicity in fission yeast are caused by the pyridoxine transporter encoded by bsu1+ (car1+)
    Jurgen Stolz
    Lehrstuhl für Zellbiologie und Pflanzenphysiologie, Universitat Regensburg, Universitatsstrasse 31, D 93040 Regensburg, Germany
    Eukaryot Cell 4:319-26. 2005
    ..Here we isolated car1+ by complementation of Saccharomyces cerevisiae mutants that are deficient in pyridoxine biosynthesis and uptake...
  58. ncbi The safety of higher than standard dose of doxylamine-pyridoxine (Diclectin) for nausea and vomiting of pregnancy
    G Atanackovic
    Division of Clinical Pharmacology Toxicology, Hospital for Sick Children, Toronto, Canada
    J Clin Pharmacol 41:842-5. 2001
    A delayed-release combination of doxylamine-pyridoxine (D-P) (Diclectin) is the only approved antiemetic medication for use in pregnancy in Canada...
  59. ncbi Pyridoxine-induced neuropathy in rats: a sensory neuropathy that responds to 4-methylcatechol
    N Callizot
    Société Neurofit SA, Immeuble le Platon, rue Jean Sapidus, F 67400 Illkirch, France
    Neurobiol Dis 8:626-35. 2001
    ..to induce a nonlethal, exclusively sensory, reversible neuropathy by intoxicating rats with large amounts of pyridoxine, using a new schedule of intoxication; (b) 4-methylcatechol, a drug known to induce nerve growth factor ..
  60. ncbi A carrier-mediated mechanism for pyridoxine uptake by human intestinal epithelial Caco-2 cells: regulation by a PKA-mediated pathway
    Hamid M Said
    Veterans Affairs Medical Center 151, Long Beach, CA 90822, USA
    Am J Physiol Cell Physiol 285:C1219-25. 2003
    ..To test this hypothesis, we examined pyridoxine transport in a model system for human enterocytes, the human-derived intestinal epithelial Caco-2 cells...
  61. ncbi A novel mutation of the erythroid-specific gamma-Aminolevulinate synthase gene in a patient with non-inherited pyridoxine-responsive sideroblastic anemia
    H Harigae
    Department of Clinical Medicine, Tohoku University School of Medicine, Sandai, Japan
    Am J Hematol 62:112-4. 1999
    ..5 of the erythroid-specific delta-aminolevulinate synthase gene (ALAS2) was identified in a Japanese male with pyridoxine-responsive sideroblastic anemia...
  62. ncbi Thiamine, pyridoxine, cyanocobalamin and their combination inhibit thermal, but not mechanical hyperalgesia in rats with primary sensory neuron injury
    Zheng Bei Wang
    Department of Neurobiology, Parker Research Institute, 2500 Walnut Hill Lane, Dallas, TX 75229, USA
    Pain 114:266-77. 2005
    ..The present study investigated the analgesic roles of the B vitamins thiamine (B1), pyridoxine (B6) and cyanocobalamin (B12) in rats with neuropathic pain caused by spinal ganglia compression (CCD) or loose ..
  63. ncbi Treatment of vincristine-induced bilateral ptosis with pyridoxine and pyridostigmine
    Lars Muller
    Department of Pediatric Hematology and Oncology, University Medical Center, Heinrich Heine University, Dusseldorf, Germany
    Pediatr Blood Cancer 42:287-8. 2004
  64. pmc Isoniazid toxicity presenting as seizures and metabolic acidosis
    R C Watkins
    Department of Emergency Medicine, Howard University Hospital, Washington, DC 20060
    J Natl Med Assoc 82:57, 62, 64. 1990
    ..are discussed, with a review of the complications and management of this metabolic encephalopathy with B6 pyridoxine. This study supports previous studies in finding that ingestion of more than 80 mg/kg body weight produces ..
  65. ncbi A double-blind, randomized trial of pyridoxine versus placebo for the prevention of pegylated liposomal doxorubicin-related hand-foot syndrome in gynecologic oncology patients
    Vivian von Gruenigen
    Department of Obstetrics and Gynecology, Summa Akron City Hospital, Akron, Ohio 44309 2090, USA
    Cancer 116:4735-43. 2010
    The objective of this study was to compare the incidence of hand-foot syndrome (HFS) in patients who received pyridoxine versus placebo during pegylated liposomal doxorubicin (PLD) chemotherapy for recurrent ovarian, breast, or ..
  66. pmc Pyridoxine-dependent seizures in Dutch patients: diagnosis by elevated urinary alpha-aminoadipic semialdehyde levels
    Levinus A Bok
    Department of Paediatrics, Maxima Medical Center, Veldhoven, The Netherlands
    Arch Dis Child 92:687-9. 2007
    b>Pyridoxine-dependent seizures (PDS) is a rare, autosomal recessively inherited disorder...
  67. ncbi Pyridoxine and pyridostigmine treatment in vincristine-induced neuropathy
    Hamit Ozyurek
    Ondokuz Mayis University, Faculty of Medicine, Department of Pediatrics, Section of Neurology, Samsun, Turkey
    Pediatr Hematol Oncol 24:447-52. 2007
    ..The patient seemed to benefit from pyridoxine and pyridostigmine therapy greatly and this therapy is recommended in patients with severe vincristine-induced ..
  68. ncbi Identification of a new tetrameric pyridoxal 4-dehydrogenase as the second enzyme in the degradation pathway for pyridoxine in a nitrogen-fixing symbiotic bacterium, Mesorhizobium loti
    Nana Yokochi
    Department of Bioresources Science, Faculty of Agriculture, Kochi University, Monobe Otsu 200, Nankoku, Kochi 783 8502, Japan
    Arch Biochem Biophys 452:1-8. 2006
    ..loti cells could grow in a nutrient-rich TY medium but not in a synthetic one containing pyridoxine or pyridoxamine as the sole carbon and nitrogen source...
  69. ncbi Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial
    Gideon Koren
    Motherisk Program, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada
    Am J Obstet Gynecol 203:571.e1-7. 2010
    To evaluate the effectiveness of Diclectin (doxylamine succinate 10 mg-pyridoxine hydrochloride 10 mg, delayed-release preparation) as compared with placebo for nausea and vomiting of pregnancy.
  70. ncbi Opposite effects of nicotinic acid and pyridoxine on systemic prostacyclin, thromboxane and leukotriene production in man
    Virpi Saareks
    Department of Pharmacological Sciences, University of Tampere, Finland
    Pharmacol Toxicol 90:338-42. 2002
    The effects of nicotinic acid (2500 mg orally during 12 hr) and pyridoxine (300 mg orally twice daily for seven days) on the excretion of urinary 2,3-dinor-6-ketoprostaglandin F1alpha, 11-dehydrothromboxane B2 and leukotriene E4, the ..
  71. ncbi Hyperhomocysteinemia is associated with low plasma pyridoxine levels in children with sickle cell disease
    Vinod V Balasa
    Cincinnati Comprehensive Sickle Cell Center of the Division of Hematology Oncology, Children s Hospital Medical Center, Ohio 45229, USA
    J Pediatr Hematol Oncol 24:374-9. 2002
    ..Plasma methylmalonic acid and pyridoxine levels were determined in 54 patients and all controls...
  72. ncbi Metabolism of vitamin B-6 by human liver
    A H Merrill
    J Nutr 114:1664-74. 1984
    ..b>Pyridoxine (pyridoxamine) 5'-phosphate oxidase (EC 1.4.3...
  73. ncbi Pharmacokinetic comparison of a delayed-release combination of doxylamine succinate and pyridoxine hydrocholoride (Diclectin) and oral solutions of these drugs in healthy women of childbearing age
    Irena Nulman
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Canada
    Can J Clin Pharmacol 16:e400-6. 2009
    The delayed-release combination of doxylamine succinate and pyridoxine hydrochloride was the most commonly used antiemetic (Bendectin) approved by FDA for nausea and vomiting of pregnancy (NVP) until its removal of the market in 1983...
  74. ncbi Identification of the pdxK gene that encodes pyridoxine (vitamin B6) kinase in Escherichia coli K-12
    Y Yang
    Department of Microbiology and Molecular Genetics, University of Texas Houston Medical School 77030 1501, USA
    FEMS Microbiol Lett 141:89-95. 1996
    We isolated a miniTn10(Cmr) insertion mutant lacking pyridoxine (PN) kinase and cloned the structural gene, designated pdxK, by complementation...
  75. ncbi Pyridoxine improves platelet nitric oxide synthase dysfunction induced by advanced glycation end products in vitro
    Yi Han
    Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    Int J Vitam Nutr Res 80:168-77. 2010
    ..The aims of this study were to determine in vitro whether pyridoxine can abrogate the impairment in platelet NOS activity caused by AGEs, and to determine the mechanism by which it ..
  76. ncbi Automatic postural responses are delayed by pyridoxine-induced somatosensory loss
    Paul J Stapley
    Neurological Sciences Institute, Oregon Health and Science University, Beaverton, Oregon 97006 3499, USA
    J Neurosci 22:5803-7. 2002
    b>Pyridoxine given in large doses is thought to destroy selectively the large-diameter peripheral sensory nerve fibers, leaving motor fibers intact...
  77. ncbi Ginkgo nut intoxication in a 2-year-old male
    Shunji Hasegawa
    Department of Allergy, Yamaguchi University, School of Medicine, and Department of Hospital Pharmacy, Niigata City General Hospital, Japan
    Pediatr Neurol 35:275-6. 2006
    ..After the treatment, his symptoms were resolved. The neurotoxicity of ginkgo nuts should be recognized by pediatricians and parents who have infants...
  78. pmc Effect of P2 receptor blockade with pyridoxine on sympathetic response to exercise pressor reflex in humans
    Jian Cui
    Penn State Heart and Vascular Institute, Pennsylvania State College of Medicine, Hershey, PA 17033, USA
    J Physiol 589:685-95. 2011
    ..this study, young healthy volunteers performed fatiguing isometric handgrip before and after a local infusion of pyridoxine (i.e. vitamin B(6)) into the 'isolated' circulation of the human forearm...
  79. ncbi Randomized trial of two different doses of pyridoxine in the prevention of capecitabine-associated palmar-plantar erythrodysesthesia
    T Chalermchai
    Medical Oncology Unit, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Asia Pac J Clin Oncol 6:155-60. 2010
    The aim of the present study was to compare the efficacy of 200 mg versus 400 mg daily of pyridoxine in preventing or delaying the onset of palmar-plantar erythrodysesthesia (PPE) in capecitabine-treated patients.
  80. pmc A randomised study evaluating the use of pyridoxine to avoid capecitabine dose modifications
    P G Corrie
    Oncology Division, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Br J Cancer 107:585-7. 2012
    b>Pyridoxine is frequently used to treat capecitabine-induced hand-foot syndrome (HFS), although the evidence of benefit is lacking...
  81. ncbi R411C mutation of the ALAS2 gene encodes a pyridoxine-responsive enzyme with low activity
    K Furuyama
    Department of Biochemistry, Tohoku University School of Medicine, Sendai, Japan
    Br J Haematol 103:839-41. 1998
    ..the erythroid-specific delta-aminolaevulinate synthase (ALAS2) gene was identified in a pedigree with X-linked pyridoxine-responsive sideroblastic anaemia (XLSA). The normal and the mutant cDNAs were expressed in E...
  82. ncbi Synergistic effects of sodium butyrate, a histone deacetylase inhibitor, on increase of neurogenesis induced by pyridoxine and increase of neural proliferation in the mouse dentate gyrus
    Dae Young Yoo
    Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul 151 742, South Korea
    Neurochem Res 36:1850-7. 2011
    We previously observed that pyridoxine (vitamin B(6)) significantly increased cell proliferation and neuroblast differentiation without any neuronal damage in the hippocampus...
  83. ncbi Coma caused by isoniazid poisoning in a patient treated with pyridoxine and hemodialysis
    Wei Ping Tai
    Department of Gastroenterology, Guangdong No 2 Provincial People s Hospital, Guangzhou, China
    Adv Ther 25:1085-8. 2008
    ..Initial treatment with large doses of pyridoxine (for 6 hours) failed to awaken this patient...
  84. ncbi Pipecolic acid: a diagnostic marker in pyridoxine-dependent epilepsy
    Michel A A P Willemsen
    Ann Neurol 58:653. 2005
  85. ncbi Pyridoxine-dependent seizures associated with hypophosphatasia in a newborn
    Magda Lahorgue Nunes
    Division of Neurology, Hospital Sao Lucas, PUCRS School of Medicine, Porto Alegre RS, Brazil
    J Child Neurol 17:222-4. 2002
    b>Pyridoxine dependency and congenital hypophosphatasia are unusual metabolic disorders. We report a female infant born from healthy consanguineous parents with shortening of limbs, detected during pregnancy by ultrasonography...
  86. ncbi Gene identification and characterization of the pyridoxine degradative enzyme alpha-(N-acetylaminomethylene)succinic acid amidohydrolase from Mesorhizobium loti MAFF303099
    Baiqiang Yuan
    Department of Bioresources Science, Faculty of Agriculture, Kochi University, Nankoku, Kochi, Japan
    J Nutr Sci Vitaminol (Tokyo) 54:185-90. 2008
    We have found for the first time that a chromosomal gene, mlr6787, in Mesorhizobium loti encodes the pyridoxine degradative enzyme alpha-(N-acetylaminomethylene)succinic acid (AAMS) amidohydrolase...
  87. ncbi Loss of dendritic connectivity in CA1, CA2, and CA3 neurons in hippocampus in rat under aluminum toxicity: antidotal effect of pyridoxine
    E Sreekumaran
    Department of Life Sciences, University of Calicut, Kerala, India
    Brain Res Bull 59:421-7. 2003
    ..These perturbations are reversed by supplementing the feed with pyridoxine (8 mg/kg) for 30 days...
  88. ncbi Simultaneous determination of nicotinamide, pyridoxine hydrochloride, thiamine mononitrate and riboflavin in multivitamin with minerals tablets by reversed-phase ion-pair high performance liquid chromatography
    Ke Li
    The Center of Medical Laboratory Science, Jinling Hospital, Clinical School of Medical College, Nanjing University, No 305 East Zhongshan Road, Jiangsu, People s Republic of China
    Biomed Chromatogr 16:504-7. 2002
    ..liquid chromatographic method (HPLC) has been developed and validated for the routine analysis of nicotinamide, pyridoxine hydrochloride, thiamine mononitrate and riboflavin in multivitamin with minerals tablets...
  89. ncbi Pyridoxine-dependent seizures: a clinical and biochemical conundrum
    Peter Baxter
    Ryegate Centre Paediatric Neurology, Sheffield Childrens Hospital, Tapton Crescent Road, Sheffield S10 5DD, UK
    Biochim Biophys Acta 1647:36-41. 2003
    b>Pyridoxine-dependent seizures have been recognised for 40 years, but the clinical and biochemical features are still not understood...
  90. ncbi Pyridoxine supplementation for the treatment of levetiracetam-induced behavior side effects in children: preliminary results
    Philippe Major
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Epilepsy Behav 13:557-9. 2008
    ..Patients followed in our center have reported improvement of these side effects after starting pyridoxine (vitamin B(6)) supplements...
  91. pmc Chemical stability study of vitamins thiamine, riboflavin, pyridoxine and ascorbic acid in parenteral nutrition for neonatal use
    Daniela O Ribeiro
    Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941 590, Brazil
    Nutr J 10:47. 2011
    ....
  92. ncbi Simultaneous determination of riboflavin, pyridoxine, nicotinamide, caffeine and taurine in energy drinks by planar chromatography-multiple detection with confirmation by electrospray ionization mass spectrometry
    Mario Aranda
    Institute of Food Chemistry, University of Hohenheim, Garbenstrasse 28, D 70599 Stuttgart, Germany
    J Chromatogr A 1131:253-60. 2006
    A new high-throughput method was developed to detect simultaneously riboflavin (Vitamin B(2)), pyridoxine (Vitamin B(6)), nicotinamide (Vitamin B(3)), caffeine and taurine in energy drinks by multiple detection...
  93. ncbi The role of the pyridoxine (vitamin B6) biosynthesis enzyme PDX1 in ultraviolet-B radiation responses in plants
    Mikael Ristilä
    School of Science and Technology and Örebro Life Science Centre, Orebro University, Orebro, Sweden
    Plant Physiol Biochem 49:284-92. 2011
    ..Some plant UV-B responses are related to the formation of reactive oxygen species (ROS) and pyridoxine (vitamin B(6)) has been reported to be a quencher of ROS...
  94. ncbi Vitamin B6 nutritional status in asthma: the effect of theophylline therapy on plasma pyridoxal-5'-phosphate and pyridoxal levels
    R Delport
    Department of Chemical Pathology, University of Pretoria, South Africa
    Int J Vitam Nutr Res 58:67-72. 1988
    ..An in vitro study showed that theophylline did not interfere with the high performance liquid chromatography assay for pyridoxal-5'-phosphate, indicating that theophylline could affect liver metabolism of vitamin B6...
  95. ncbi Properties and interaction of heterologously expressed glutamate decarboxylase isoenzymes GAD(65kDa) and GAD(67kDa) from human brain with ginkgotoxin and its 5'-phosphate
    K Buss
    , , Nussallee 6, 53115 Bonn, Germany
    J Med Chem 44:3166-74. 2001
    ....
  96. ncbi Homocysteine-lowering treatment with folic acid, cobalamin, and pyridoxine does not reduce blood markers of inflammation, endothelial dysfunction, or hypercoagulability in patients with previous transient ischemic attack or stroke: a randomized substudy o
    P Dusitanond
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
    Stroke 36:144-6. 2005
    ....
  97. ncbi High-yielding enzymatic alpha-glucosylation of pyridoxine by marine alpha-glucosidase from Aplysia fasciata
    Annabella Tramice
    Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80072 Pozzuoli, Naples, Italy
    Mar Biotechnol (NY) 8:448-52. 2006
    ..High-yielding enzymatic alpha-glycosylation of pyridoxine using this marine enzyme is reported here; the reaction has been optimized, reaching 80% molar yield of products ..
  98. ncbi Pyridoxine-dependent seizures: new genetic and biochemical clues to help with diagnosis and treatment
    Sidney M Gospe
    Division of Pediatric Neurology, Departments of Neurology and Pediatrics, University of Washington, Seattle, WA 98105, USA
    Curr Opin Neurol 19:148-53. 2006
    b>Pyridoxine dependency is an uncommon but important cause of intractable seizures presenting in infancy and early childhood...
  99. ncbi Mutation and polymorphic marker analyses of 65K- and 67K-glutamate decarboxylase genes in two families with pyridoxine-dependent epilepsy
    S Kure
    Department of Biochemical Genetics, Tohoku University School of Medicine, Sendai, Japan
    J Hum Genet 43:128-31. 1998
    b>Pyridoxine-dependent epilepsy is a disease inherited as an autosomal recessive trait, characterized by rapid response to pharmacological dosages of pyridoxine...
  100. ncbi Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group. EORTC Genito-Urinary Tract Cancer Cooperative G
    D W Newling
    Free University Hospital, Department of Urology, Amsterdam, The Netherlands
    Eur Urol 27:110-6. 1995
    This double-blind randomised phase III trial was designed to assess the effect of pyridoxine administration on the recurrence of Ta and T1 transitional cell tumours of the bladder...
  101. pmc Isolation of PDX2, a second novel gene in the pyridoxine biosynthesis pathway of eukaryotes, archaebacteria, and a subset of eubacteria
    M Ehrenshaft
    Department of Plant Pathology, North Carolina State University, Raleigh, NC 27695, USA
    J Bacteriol 183:3383-90. 2001
    In this paper we describe the isolation of a second gene in the newly identified pyridoxine biosynthesis pathway of archaebacteria, some eubacteria, fungi, and plants...

Research Grants61

  1. Cystathionine beta synthase (CBS) and angiogenesis
    Priyabrata Mukherjee; Fiscal Year: 2013
    ....
  2. Maternal One Carbon Metabolism and Low Birth Weight Infant
    Satish C Kalhan; Fiscal Year: 2013
    ..document maternal methionine, homocysteine metabolism, relate it to nutrient (protein) intake, folate, B12, pyridoxine status, and measures of insulin resistance...
  3. Vitamin B6 Effects on One-Carbon Metabolism
    Jesse F Gregory; Fiscal Year: 2013
    ..kinetic and metabolomic assessments will be conducted in OC users before and after supplementation with pyridoxine to allow a thorough functional evaluation of unsupplemented OC users and the metabolic restoration provided by ..
  4. The role of GABA-mimetic metabolites in neurodevelopmental and neuropsychiatric d
    Joseph A Gogos; Fiscal Year: 2013
    ..porphyria, a disease associated with psychosis and seizures, and L-pipecolic acid, which accumulates in pyridoxine (vitamin B6) dependent epilepsy, a disease associated with seizures...
  5. Ninth International Primary Hyperoxaluria Workshop
    Ross P Holmes; Fiscal Year: 2010
    ..There is no known cure apart from a small percentage of individuals who respond completely to pyridoxine therapy...
  6. VITAMIN B2 AND B6 IN VERY LOW BIRTH WEIGHT INFANTS
    LARRY SWIFT; Fiscal Year: 1992
    ..riboflavin and marked increases in plasma B6 vitamers were also noted with the current recommended dose of pyridoxine. Both findings appear to be due in part to renal and hepatic immaturity...
  7. Bioactivity and Vitamins in Flash-heated Breastmilk
    Caroline Chantry; Fiscal Year: 2005
    ..unheated milk we will measure and compare: a) concentrations of vitamins A, ascorbic acid, thiamine, riboflavin, pyridoxine, folate and B12, known to be relatively heat-sensitive; b) concentration and digestability of proteins lysozyme ..
  8. REGULATION OF PYRIDOXAL PHOSPHATE BIOSYNTHESIS IN E COLI
    Malcolm Winkler; Fiscal Year: 1999
    ..for these physiological, genetic, and biochemical studies, because it synthesizes a form of the PLP-precursor, pyridoxine (PN; vitamin B6), like plants and certain other microorganisms, and can convert PN, pyridoxal (PL), and ..
  9. GENETIC MODULATION OF CBS TO LOWER PLASMA HOMOCYSTEINE
    Warren Kruger; Fiscal Year: 2009
    ..Some CBS-deficient patients respond clinically to pharmacologic doses of pyridoxine (vitamin B6)...
  10. Hyperhomocysteinemia in Alzheimer's Disease
    Ramon Diaz Arrastia; Fiscal Year: 2003
    ..Since vitamin supplementation with folic acid, vitamin B12, and pyridoxine can lower homocysteine levels, this association raises the exciting possibility that polyvitamin therapy may ..
  11. VITAMIN B6 ADEQUACY, SMOKING AND DNA DAMAGE
    Terry Shultz; Fiscal Year: 2002
    ..Vitamin B-6 metabolite concentrations [i.e., pyridoxal phosphate (PLP), pyridoxamine phosphate, pyridoxal, pyridoxine and 4-pyridoxic acid] will be determined in plasma and erythrocytes, and PLP concentrations measured in ..
  12. EFFICACY OF TB CHEMOPROPHYLAXIS IN PPD, HIV ADULTS
    Jacqueline Coberly; Fiscal Year: 1999
    ..Eligible residents of Cite Soleil (n=345) will be randomized to receive isoniazid and pyridoxine (B6) daily for six months, rifampin and B6 daily for three months followed by daily B6 for three months, or B6 ..
  13. PERTURBATIONS IN VITAMIN B6 METABOLISM IN CANCER
    LOUISE NUTTER; Fiscal Year: 2000
    ..In particular, pyridoxine 5'- phosphate oxidase (PNPO), the rate limiting enzyme in the synthesis of the active form of vitamin B6 (i.e...
  14. NUTRITIONAL PROPERTIES OF PYRIDOXINE-BETA-GLUCOSIDE
    JESSE GREGORY; Fiscal Year: 2001
    DESCRIPTION: Pyridoxine-beta-glucoside (PNG) is a major component of vitamin B6 (B6) in plant foods, and PNG hydrolysis catalyzed by PNG hydrolase is rate limiting for the in vivo utilization...
  15. REGULATION OF MAMMALIAN PYRIDOXAL PHOSPHATE METABOLISM
    MARGARET FONDA; Fiscal Year: 1980
    ..These are aldehyde oxidase from mammalian liver and pyridoxine-P oxidase and vitamin B6-P phosphatase from human erythrocytes...
  16. 5-Aminolevulinate Synthase and Heme Biosynthesis
    Gloria Ferreira; Fiscal Year: 2006
    ..The prospect of developing pyridoxine-based therapies of universal efficacy for XLSA relies on the knowledge of the mechanism of ALAS, the cofactor-..
  17. VITAMIN B-6 NUTRITIONAL STATUS ASSESSMENT IN PREGNANCY
    Andrew Smolen; Fiscal Year: 1993
    ..Mice will be fed one of five dietary levels of vitamin B-6 (pyridoxine-Hcl) to determine the effect of dietary intake on these nutritional status indices...
  18. LONG ORAL CONTRACEPTIVE USE/VITAMIN B-6 PREGNANCY NEEDS
    Avanelle Kirksey; Fiscal Year: 1980
    ..Subjects will be randomly assigned to four groups to receive supplements of 2.5, 5, l0, or 15 mg pyridoxine/day...
  19. NEURAL CONTROL OF POSTURE AND STANCE
    JANE MACPHERSON; Fiscal Year: 2002
    ..somatosensory afferents in balance using a novel model of peripheral sensory neuropathy, in which a high dose of pyridoxine (vitamin B6) is used to induce widespread deafferentation...
  20. THE GENETICS OF PREGNANCY-INDUCED SEIZURES IN MICE
    Andrew Smolen; Fiscal Year: 1992
    ..study the effects of vitamin B6 nutriture on brain neurochemistry in pregnancy by adjusting the dietary level of pyridoxine. Two strains of mice which differ in susceptibility to pregnancy-induced seizures will be used to study the ..
  21. VITAMIN INTERVENTION FOR STROKE PREVENTION (VISP)
    James Toole; Fiscal Year: 2006
    ..Treatment with a combination of folic acid, pyridoxine (vitamin B6) and cobalamin (vitamin B12) reduces plasma H(e) levels in most cases, restores endothelial function,..
  22. Vitamin B6 Biosynthesis: A study of the pdxJ Mechanism
    VALERIE FRYDRYCHOWSKI BURKE; Fiscal Year: 2002
    ..PdxJ, or pyridoxine 5'-phosphate synthase, is known to catalyze the condensation of 1 -aminoacetone-3-phosphate and 1 -deoxy-D-..
  23. Aromatic Metabolism: A Web of Biochemical Networks
    Roy Jensen; Fiscal Year: 2006
    ..synthesis, as well as the more remote relationships that also include folate biosynthesis (via 4-aminobenzoate), pyridoxine biosynthesis, and histidine biosynthesis...
  24. PHYSICAL ACTIVITY INDUCES NEUROTROPHIC FACTORS
    Fernando Gomez Pinilla; Fiscal Year: 2002
    ..Thirdly, the PI will determine whether locomotor deficit caused by degeneration of large muscle afferents (by using high doses of pyridoxine) can be countered by daily locomotion induction of neurotrophins.
  25. Psychosocial & Nutritional Associations with Depression
    CRISTINA MERETE; Fiscal Year: 2006
    ..Research with B vitamins suggests that folate, cobalamin and pyridoxine status correlate with depressive symptomatology...
  26. C elegans:a model to study intestinal water-soluble vitamins transport in vivo
    HAMID SAID; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  27. Mechanism/regulation of human intestinal thiamin uptake
    HAMID SAID; Fiscal Year: 2008
    ..This should ultimately assist us in the designing of effective strategies to optimize thiamin body homeostasis in conditions associated with thiamin deficiency and sub-optimal levels. ..
  28. Role of 10-formyldihydrofolate in purine biosynthesis
    Tsunenobu Tamura; Fiscal Year: 2004
    ..If this pathway is proven, derivatives of 10-HCO-H2folate could be used to inhibit de novo purine biosynthesis for developing new anticancer drugs. ..
  29. Influence of genotype on urinary oxalate excretion
    CARLA MONICO; Fiscal Year: 2007
    ..3) The effect of normal allelic variation at the AGT locus on urine oxalate excretion and pyridoxine responsiveness will be defined in a group of idiopathic calcium oxalate stone formers...
  30. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil K Jain; Fiscal Year: 2010
    ..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..
  31. Adjuvant Therapy for Vascular Inflammation in Diabetes
    Sushil Jain; Fiscal Year: 2006
    ..abstract_text> ..
  32. Vascular factors, amyloid beta, and Alzheimer's disease
    Jose Luchsinger; Fiscal Year: 2004
    ..abstract_text> ..
  33. Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  34. New DHFR Deletion Polymorphism - A Risk Factor for SB?
    William Johnson; Fiscal Year: 2003
    ..Forms of foliate that are already reduced could be preferable as foliate supplements during pregnancy for prevention of SB. ..
  35. Arterial stiffness, blood pressure and cognition
    Merrill Elias; Fiscal Year: 2009
    ....
  36. Function and regulation of cardiac uncoupling proteins
    Raymond Russell; Fiscal Year: 2009
    ..It is anticipated that the results of these studies will yield important insights into the role of UCPs in the clinically important disorders of myocardial ischemia/reperfusion and heart failure. ..
  37. EVALUATION OF NIKKOMYCIN Z PHARMACOLOGY FOR TREATMENT OF UNCOMPLICATED COCCIDIODE
    David Nix; Fiscal Year: 2009
    ..By carrying out the proposed work, the investigators will resume the clinical development of nikkomycin Z as a potentially curative therapy for coccidioidomycosis so that it may become a candidate for final commercial development. ..
  38. Pilot Trial of Metformin in Amnestic MCI
    Jose A Luchsinger; Fiscal Year: 2010
    ....
  39. Sulfur Amino Acid Metabolism in NAFLD
    Satish C Kalhan; Fiscal Year: 2010
    ..The proposed studies are aimed at examining the metabolic mechanisms involved in the progression of this disease, so that specific targeted intervention strategies related to the stage of the disease can be identified and evaluated. ..
  40. Osteoporosis in Hypercalciuric Kidney Stone Formers
    John Asplin; Fiscal Year: 2003
    ..We hope to use the algorithm developed in this research to expand out services to include bone disease management in kidney stone forming patients and their families. ..
  41. RANDOMIZED TRIALS OF VITAMIN SUPPLEMENTS AND EYE DISEASE
    William Christen; Fiscal Year: 2002
    ....
  42. FASEB Summer Conference: Folate, B12 and 1C Metabolism
    JAMES FINKELSTEIN; Fiscal Year: 2002
    ..The format encourages discussions between the presenters and the fellows, residents and junior investigators in attendance. Similarly, the poster sessions also highlight the activities and the needs of the younger participants. ..
  43. AGE, RISK FACTORS FOR CVD AND COGNITIVE FUNCTIONING
    Merrill Elias; Fiscal Year: 2002
    ....
  44. Nutritional/Inflammatory Evaluation of Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2005
    ....
  45. ENDOCRINE EFFECTS OF HUMAN LEPTIN REPLACEMENT
    Julio Licinio; Fiscal Year: 2005
    ..Discontinuation of this study would be highly deleterious, not only for the patients, but also for our understanding of the long-term effects of leptin in humans. ..
  46. Regulation of energy metabolism in the failing heart
    Raymond Russell; Fiscal Year: 2005
    ..The findings of these studies will help to characterize the defects in energy metabolism in the failing heart and aid in the design of therapies that improve energy transduction in the failing human heart. ..
  47. Developing Educational Approaches for Mexican-Americans
    Julio Licinio; Fiscal Year: 2005
    ..Their input will also be incorporated into the article that will be submitted to a peer-reviewed journal. ..
  48. Studies of Human Folate Hydrolase
    Charles Halsted; Fiscal Year: 2005
    ..abstract_text> ..
  49. SAMe and Folate Deficiency in Alcoholic Mircropigs
    Charles Halsted; Fiscal Year: 2006
    ..While furthering understanding of interactions of methionine metabolites on pathways of liver injury, the project may establish novel approaches to the prevention and treatment of ALD. [unreadable] [unreadable] [unreadable]..
  50. Dietary Factors in Eye Disease
    William Christen; Fiscal Year: 2006
    ..Thus, the proposed analyses represent an extremely cost-effective opportunity to compare directly the predictive ability of several potentially modifiable risk factors for ARM and cataract in women and men. ..
  51. Flavocoxid: A Medical Food Therapy for Osteoarthritis
    Sarah Morgan; Fiscal Year: 2004
    ..This innovative compound has commercial potential with its expected efficacy comparable to or exceeding the currently marketed COX inhibitors but with fewer side effects and at a significantly lower cost. ..
  52. Glutamine Metabolism in the Human Newborn
    Satish Kalhan; Fiscal Year: 2007
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page .............................................................................................................................................. 1 Description, ..
  53. New CVD risk factors for lowered congitive functioning
    Merrill Elias; Fiscal Year: 2005
    ....
  54. EFFECTS OF SAM IN PATIENTS WITH ALCOHOLIC LIVER DISEASE
    Charles Halsted; Fiscal Year: 2007
    ..By confirming the relationship of abnormal methionine metabolism to clinical, biochemical, and pathologic disease severity, the study will establish a metabolic basis for determining the efficacy of SAM intervention in ALD. ..
  55. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  56. Eye Disease in a Trial of Selenium and Vitamin E
    William Christen; Fiscal Year: 2007
    ..abstract_text> ..
  57. UCLA GRADUATE TRAINING PROGRAM IN TRANSITIONAL INVESTIGA
    Julio Licinio; Fiscal Year: 2004
    ..abstract_text> ..
  58. Treatment of Calcium Nephrolithiasis Sodium Thiosulfate
    John Asplin; Fiscal Year: 2006
    ..New, more effective and better tolerated drugs are needed to reduce the recurrence of kidney stones in these patients. [unreadable] [unreadable] [unreadable]..