nevirapine

Summary

Summary: A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV infection and AIDS.

Top Publications

  1. ncbi Predictors of virologic failure and resistance in HIV-infected patients treated with nevirapine- or efavirenz-based antiretroviral therapy
    Jean Jacques Parienti
    Department of Infectious Diseases and Virology, Côte de Nacre Hospital, Caen, France
    Clin Infect Dis 38:1311-6. 2004
  2. ncbi Coverage of nevirapine-based services to prevent mother-to-child HIV transmission in 4 African countries
    Elizabeth M Stringer
    Centre for Infectious Disease Research in Zambia, Plot 1275 Lubutu Rd, PO Box 34681, Lusaka, Zambia
    JAMA 304:293-302. 2010
  3. pmc HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism
    Kalyan Das
    Center for Advanced Biotechnology and Medicine, Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, USA
    Nat Struct Mol Biol 19:253-9. 2012
  4. pmc Nevirapine- versus lopinavir/ritonavir-based initial therapy for HIV-1 infection among women in Africa: a randomized trial
    Shahin Lockman
    Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS Med 9:e1001236. 2012
  5. ncbi Comparison of first-line antiretroviral therapy with regimens including nevirapine, efavirenz, or both drugs, plus stavudine and lamivudine: a randomised open-label trial, the 2NN Study
    F van Leth
    International Antiviral Therapy Evaluation Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
    Lancet 363:1253-63. 2004
  6. ncbi Outcomes of nevirapine- and efavirenz-based antiretroviral therapy when coadministered with rifampicin-based antitubercular therapy
    Andrew Boulle
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    JAMA 300:530-9. 2008
  7. pmc Nevirapine versus ritonavir-boosted lopinavir for HIV-infected children
    Avy Violari
    Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    N Engl J Med 366:2380-9. 2012
  8. pmc Antiretroviral treatment for children with peripartum nevirapine exposure
    Paul Palumbo
    Department of Medicine, Dartmouth Medical School, Lebanon, NH 03765, USA
    N Engl J Med 363:1510-20. 2010
  9. pmc N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance
    Soo Huey Yap
    Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    PLoS Med 4:e335. 2007
  10. ncbi High rate of early virological failure with the once-daily tenofovir/lamivudine/nevirapine combination in naive HIV-1-infected patients
    D Rey
    COREVIH, Hopitaux Universitaires, Strasbourg, France
    J Antimicrob Chemother 63:380-8. 2009

Detail Information

Publications319 found, 100 shown here

  1. ncbi Predictors of virologic failure and resistance in HIV-infected patients treated with nevirapine- or efavirenz-based antiretroviral therapy
    Jean Jacques Parienti
    Department of Infectious Diseases and Virology, Côte de Nacre Hospital, Caen, France
    Clin Infect Dis 38:1311-6. 2004
    ..8-180.3; P<.0001). Patients' previous adherence to therapy and drugs genetic barriers, not only the number of pills or doses involved, should be taken into consideration in the decision to simplify highly active antiretroviral therapy...
  2. ncbi Coverage of nevirapine-based services to prevent mother-to-child HIV transmission in 4 African countries
    Elizabeth M Stringer
    Centre for Infectious Disease Research in Zambia, Plot 1275 Lubutu Rd, PO Box 34681, Lusaka, Zambia
    JAMA 304:293-302. 2010
    ..Few studies have objectively evaluated the coverage of services to prevent transmission of human immunodeficiency virus (HIV) from mother to child...
  3. pmc HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism
    Kalyan Das
    Center for Advanced Biotechnology and Medicine, Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, USA
    Nat Struct Mol Biol 19:253-9. 2012
    ..Five NNRTIs, including nevirapine, are clinical drugs; however, the molecular mechanism of inhibition by NNRTIs is not clear...
  4. pmc Nevirapine- versus lopinavir/ritonavir-based initial therapy for HIV-1 infection among women in Africa: a randomized trial
    Shahin Lockman
    Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS Med 9:e1001236. 2012
    b>Nevirapine (NVP) is widely used in antiretroviral treatment (ART) of HIV-1 globally. The primary objective of the AA5208/OCTANE trial was to compare the efficacy of NVP-based versus lopinavir/ritonavir (LPV/r)-based initial ART.
  5. ncbi Comparison of first-line antiretroviral therapy with regimens including nevirapine, efavirenz, or both drugs, plus stavudine and lamivudine: a randomised open-label trial, the 2NN Study
    F van Leth
    International Antiviral Therapy Evaluation Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
    Lancet 363:1253-63. 2004
    The 2NN Study was a randomised comparison of the non-nucleoside reverse-transcriptase inhibitors (NNRTI) nevirapine and efavirenz.
  6. ncbi Outcomes of nevirapine- and efavirenz-based antiretroviral therapy when coadministered with rifampicin-based antitubercular therapy
    Andrew Boulle
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    JAMA 300:530-9. 2008
    Rifampicin-based antitubercular therapy reduces the plasma concentrations of nevirapine and efavirenz. The virological consequences of these interactions are not well described.
  7. pmc Nevirapine versus ritonavir-boosted lopinavir for HIV-infected children
    Avy Violari
    Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    N Engl J Med 366:2380-9. 2012
    b>Nevirapine-based antiretroviral therapy is the predominant (and often the only) regimen available for children in resource-limited settings...
  8. pmc Antiretroviral treatment for children with peripartum nevirapine exposure
    Paul Palumbo
    Department of Medicine, Dartmouth Medical School, Lebanon, NH 03765, USA
    N Engl J Med 363:1510-20. 2010
    Single-dose nevirapine is the cornerstone of the regimen for prevention of mother-to-child transmission of human immunodeficiency virus (HIV) in resource-limited settings, but nevirapine frequently selects for resistant virus in mothers ..
  9. pmc N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance
    Soo Huey Yap
    Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    PLoS Med 4:e335. 2007
    ..The objective of this multidisciplinary study was to establish the in vivo relevance of this mutation and its role in drug resistance...
  10. ncbi High rate of early virological failure with the once-daily tenofovir/lamivudine/nevirapine combination in naive HIV-1-infected patients
    D Rey
    COREVIH, Hopitaux Universitaires, Strasbourg, France
    J Antimicrob Chemother 63:380-8. 2009
    ..The once-daily combination of lamivudine, tenofovirDF and nevirapine has not been evaluated in a clinical trial.
  11. pmc Efficacy and safety of an extended nevirapine regimen in infant children of breastfeeding mothers with HIV-1 infection for prevention of postnatal HIV-1 transmission (HPTN 046): a randomised, double-blind, placebo-controlled trial
    Hoosen M Coovadia
    Maternal Adolescent and Child Health MatCH, University of the Witwatersrand, Johannesburg, South Africa
    Lancet 379:221-8. 2012
    b>Nevirapine given once-daily for the first 6, 14, or 28 weeks of life to infants exposed to HIV-1 via breastfeeding reduces transmission through this route compared with single-dose nevirapine at birth or neonatally...
  12. ncbi Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi Study
    Ibou Thior
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 296:794-805. 2006
    ..Postnatal transmission of human immunodeficiency virus-1 (HIV) via breastfeeding reverses gains achieved by perinatal antiretroviral interventions...
  13. ncbi Factors influencing efavirenz and nevirapine plasma concentration: effect of ethnicity, weight and co-medication
    Wolfgang Stöhr
    MRC Clinical Trials Unit, London, UK
    Antivir Ther 13:675-85. 2008
    The aim of this study was to examine factors influencing plasma concentration of efavirenz and nevirapine.
  14. pmc Antiretroviral regimens in pregnancy and breast-feeding in Botswana
    R L Shapiro
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, 110 Francis St, Suite GB, Boston, MA 02215, USA
    N Engl J Med 362:2282-94. 2010
    ..The most effective highly active antiretroviral therapy (HAART) to prevent mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) in pregnancy and its efficacy during breast-feeding are unknown...
  15. ncbi Cost-effectiveness of nevirapine to prevent mother-to-child HIV transmission in eight African countries
    Michael D Sweat
    Department of International Health, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    AIDS 18:1661-71. 2004
    ..Most attention has been given to preventing vertical transmission based on analysis showing nevirapine to be inexpensive and cost-effective.
  16. ncbi Pharmacokinetic parameters of nevirapine and efavirenz in relation to antiretroviral efficacy
    F Van Leth
    International Antiviral Therapy Evaluation Center, Department of Internal Medicine, Academic Medical Center, University of Amsterdam, 1005 Amsterdam, The Netherlands
    AIDS Res Hum Retroviruses 22:232-9. 2006
    ..Cmin) and total drug exposure over 24 hr (AUC24) with virologic failure for therapy-adherent patients in the nevirapine (NVP) and efavirenz (EFV) groups of the double nonnucleoside study (2NN), which compared the efficacy of NVP and/..
  17. ncbi Nevirapine versus efavirenz for patients co-infected with HIV and tuberculosis: a randomised non-inferiority trial
    Maryline Bonnet
    Epicentre, Paris, France
    Lancet Infect Dis 13:303-12. 2013
    In countries with a high incidence of HIV and tuberculosis co-infection, nevirapine and efavirenz are widely used as antiretroviral therapy but both interact with antituberculosis drugs...
  18. ncbi HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in HIV-infected Thai patients
    Soranun Chantarangsu
    Research Group for Pharmacogenomics, RIKEN, Center for Genomic Medicine, Tokyo, Japan
    Pharmacogenet Genomics 19:139-46. 2009
    Investigation of a possible involvement of differences in human leukocyte antigens (HLA) in the risk of nevirapine (NVP)-induced skin rash among HIV-infected patients.
  19. ncbi Female sex and the use of anti-allergic agents increase the risk of developing cutaneous rash associated with nevirapine therapy
    A Antinori
    National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy
    AIDS 15:1579-81. 2001
    ..multicentre analysis of HIV outpatients starting a highly active antiretroviral therapy regimen containing nevirapine. A total of 62 cutaneous adverse events were observed in 429 patients...
  20. ncbi Adverse events associated with nevirapine and efavirenz-based first-line antiretroviral therapy: a systematic review and meta-analysis
    Zara Shubber
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, London, UK
    AIDS 27:1403-12. 2013
    Since 2002, the WHO has recommended either nevirapine (NVP) or efavirenz (EFV) as part of first-line antiretroviral therapy...
  21. ncbi Metabolic abnormalities and body composition of HIV-infected children on Lopinavir or Nevirapine-based antiretroviral therapy
    Stephen Arpadi
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University Medical Center, 630 W 168th Street, New York, NY 10032, USA
    Arch Dis Child 98:258-64. 2013
    ..We compared metabolic profiles and regional fat of children on ritonavir-boosted lopinavir (lopinavir/ritonavir), lamivudine and stavudine to those switched to nevirapine, lamivudine and stavudine.
  22. ncbi Determinants of adherence to a single-dose nevirapine regimen for the prevention of mother-to-child HIV transmission in Gert Sibande district in South Africa
    Karl Peltzer
    Human Sciences Research Council, Pretoria, South Africa
    Acta Paediatr 99:699-704. 2010
    ..To identify factors that influence adherence to antiretroviral (ARV) prophylaxis by HIV positive mothers participating in the HIV prevention of mother to child (PMTCT) programme...
  23. ncbi Prevalence and risk factors for developing K65R mutations among HIV-1 infected patients who fail an initial regimen of fixed-dose combination of stavudine, lamivudine, and nevirapine
    Somnuek Sungkanuparph
    Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama 6 Road, Bangkok 10400, Thailand
    J Clin Virol 41:310-3. 2008
    A fixed-dose combination of stavudine, lamivudine, and nevirapine (d4T/3TC/NVP) is extensively used as initial antiretroviral regimen in developing countries...
  24. ncbi Strategies for nevirapine initiation in HIV-infected children taking pediatric fixed-dose combination "baby pills" in Zambia: a randomized controlled trial
    V Mulenga
    University Teaching Hospital, Lusaka, Zambia
    Clin Infect Dis 51:1081-9. 2010
    Fixed-dose combination scored dispersible stavudine, lamivudine, and nevirapine minitablets (Triomune Baby and Junior; Cipla Ltd) are simpler and cheaper than liquid formulations and have correct dose ratios for human immunodeficiency ..
  25. ncbi Clinical toxicity of highly active antiretroviral therapy in a home-based AIDS care program in rural Uganda
    Fatu Forna
    Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Acquir Immune Defic Syndr 44:456-62. 2007
    ..We evaluated clinical toxicity in HIV-infected persons receiving antiretroviral therapy (ART) in Uganda...
  26. pmc Persistent minority K103N mutations among women exposed to single-dose nevirapine and virologic response to nonnucleoside reverse-transcriptase inhibitor-based therapy
    Ashraf Coovadia
    Empilweni Clinic, Coronation Women and Children Hospital, Johannesburg, South Africa
    Clin Infect Dis 48:462-72. 2009
    We investigated whether there are long-lasting effects of exposure to single-dose nevirapine (sdNVP) treatment on virologic response to nonnucleoside reverse-transcriptase inhibitor (NNRTI)-based therapy among human immunodeficiency virus ..
  27. pmc Antiretroviral therapies in women after single-dose nevirapine exposure
    Shahin Lockman
    Brigham and Women s Hospital, Boston, MA, USA
    N Engl J Med 363:1499-509. 2010
    Peripartum administration of single-dose nevirapine reduces mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) but selects for nevirapine-resistant virus.
  28. ncbi Low-frequency K103N strengthens the impact of transmitted drug resistance on virologic responses to first-line efavirenz or nevirapine-based highly active antiretroviral therapy
    Anna Maria Geretti
    Department of Virology, Royal Free Hampstead NHS Trust, London, UK
    J Acquir Immune Defic Syndr 52:569-73. 2009
    ..There are conflicting data on the impact of low-frequency transmitted drug-resistant mutants on responses to first-line highly active antiretroviral therapy (HAART)...
  29. pmc Nevirapine and efavirenz elicit different changes in lipid profiles in antiretroviral-therapy-naive patients infected with HIV-1
    Frank van Leth
    International Antiviral Therapy Evaluation Center, Division of Infectious Diseases, Tropical Medicine, and AIDS, Department of Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    PLoS Med 1:e19. 2004
    ..We analysed whether lipid changes differed between the two most commonly used NNRTIs, nevirapine (NVP) and efavirenz (EFV).
  30. ncbi High exposure to nevirapine in plasma is associated with an improved virological response in HIV-1-infected individuals
    A I Veldkamp
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands
    AIDS 15:1089-95. 2001
    OBJECTIVE: To explore relationships between exposure to nevirapine and the virological response in HIV-1-infected individuals participating in the INCAS trial...
  31. ncbi Risk factors for treatment-limiting toxicities in patients starting nevirapine-containing antiretroviral therapy
    Anouk M Kesselring
    HIV Monitoring Foundation, The Netherlands
    AIDS 23:1689-99. 2009
    ..collaboration of seven observational clinical cohorts investigated risk factors for treatment-limiting toxicities in both antiretroviral-naive and experienced patients starting nevirapine-based combination antiretroviral therapy (NVPc).
  32. ncbi A randomized trial comparing plasma drug concentrations and efficacies between 2 nonnucleoside reverse-transcriptase inhibitor-based regimens in HIV-infected patients receiving rifampicin: the N2R Study
    Weerawat Manosuthi
    Dept of Medicine, Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Tiwanon Rd, Nonthaburi 11000, Thailand
    Clin Infect Dis 48:1752-9. 2009
    ..our knowledge, to date, no prospective, randomized, clinical trial has compared standard doses of efavirenz- and nevirapine-based antiretroviral therapy among patients with concurrent human immunodeficiency virus type 1 (HIV-1) ..
  33. pmc Couples' voluntary counselling and testing and nevirapine use in antenatal clinics in two African capitals: a prospective cohort study
    Martha Conkling
    Emory University, Atlanta, Georgia, USA
    J Int AIDS Soc 13:10. 2010
    ..This study was conducted to assess the feasibility of couples' voluntary counseling and testing (CVCT) in antenatal care and to measure compliance with PMTCT...
  34. pmc Comparing two service delivery models for the prevention of mother-to-child transmission (PMTCT) of HIV during transition from single-dose nevirapine to multi-drug antiretroviral regimens
    Landry Tsague
    International Center for AIDS Care and Treatment Programs, Kigali, Rwanda
    BMC Public Health 10:753. 2010
    ..compares two service delivery models of PMTCT interventions and documents the lessons learned and the challenges encountered during the transition from single-dose nevirapine (sd-nvp) to md-ARV regimens in a resource-limited setting.
  35. pmc Prevention of mother-to-child transmission of HIV infection: views and perceptions about swallowing nevirapine in rural Lilongwe, Malawi
    Deirdre A O'Gorman
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    BMC Public Health 10:354. 2010
    ..Urban men's and rural traditional birth attendants' (TBAs) involvement have improved uptake of HIV testing and of nevirapine.
  36. pmc Toxicogenomics of nevirapine-associated cutaneous and hepatic adverse events among populations of African, Asian, and European descent
    Jing Yuan
    Non Clinical Drug Safety, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, Connecticut 06877, USA
    AIDS 25:1271-80. 2011
    b>Nevirapine is widely prescribed for HIV-1 infection. We characterized relationships between nevirapine-associated cutaneous and hepatic adverse events and genetic variants among HIV-infected adults.
  37. pmc Efficacy of short-course AZT plus 3TC to reduce nevirapine resistance in the prevention of mother-to-child HIV transmission: a randomized clinical trial
    James A McIntyre
    Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    PLoS Med 6:e1000172. 2009
    Single-dose nevirapine (sdNVP)-which prevents mother-to-child transmission of HIV-selects non-nucleoside reverse-transcriptase inhibitor (NNRTI) resistance mutations in the majority of women and HIV-infected infants receiving it...
  38. pmc TMC278, a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1
    Hilde Azijn
    Tibotec Virco BVBA, Generaal De Wittelaan L11 B3, B 2800 Mechelen, Belgium
    Antimicrob Agents Chemother 54:718-27. 2010
    ..However, in the setting of incomplete viral suppression, efavirenz and nevirapine select for resistant viruses...
  39. ncbi Efficacy and safety of once-daily nevirapine- or efavirenz-based antiretroviral therapy in HIV-associated tuberculosis: a randomized clinical trial
    Soumya Swaminathan
    Department of Clinical Research, Tuberculosis Research Centre, Indian Council of Medical Research, Chennai, India
    Clin Infect Dis 53:716-24. 2011
    b>Nevirapine (NVP) can be safely and effectively administered once-daily but has not been assessed in human immunodeficiency virus (HIV)-infected patients with tuberculosis (TB)...
  40. pmc The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine
    Matthew M Schuckmann
    Christopher Bond Life Sciences Center, Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, Missouri 65211, USA
    J Biol Chem 285:38700-9. 2010
    ..the enzymatic properties of N348I RT and determine the biochemical mechanism of resistance to the NNRTI nevirapine (NVP)...
  41. pmc First-line antiretroviral therapy after single-dose nevirapine exposure in South Africa: a cost-effectiveness analysis of the OCTANE trial
    Andrea L Ciaranello
    Division of Infectious Disease, Massachusetts General Hospital, Boston, 02114, USA
    AIDS 25:479-92. 2011
    The OCTANE trial reports superior outcomes of lopinavir/ritonavir vs. nevirapine-based antiretroviral therapy (ART) among women previously exposed to single-dose nevirapine to prevent mother-to-child HIV transmission...
  42. ncbi Stavudine- and nevirapine-related drug toxicity while on generic fixed-dose antiretroviral treatment: incidence, timing and risk factors in a three-year cohort in Kigali, Rwanda
    Johan van Griensven
    Medecins Sans Frontieres, Operational Centre Brussels, Medical Department, Duprestraat 94, 1090 Brussels, Belgium
    Trans R Soc Trop Med Hyg 104:148-53. 2010
    This cohort study was conducted to report on the incidence, timing and risk factors for stavudine (d4T)- and nevirapine (NVP)-related severe drug toxicity (requiring substitution) with a generic fixed-dose combination under program ..
  43. ncbi Nevirapine/zidovudine/lamivudine has superior immunological and virological responses not reflected in clinical outcomes in a 48-week randomized comparison with abacavir/zidovudine/lamivudine in HIV-infected Ugandan adults with low CD4 cell counts
    P Munderi
    MRC UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
    HIV Med 11:334-44. 2010
    ..Concerns exist about virological potency; efficacy has not been assessed in Africa...
  44. ncbi Switching children previously exposed to nevirapine to nevirapine-based treatment after initial suppression with a protease-inhibitor-based regimen: long-term follow-up of a randomised, open-label trial
    Louise Kuhn
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, and Department of Epidemiology, Columbia University, New York, NY 10032, USA
    Lancet Infect Dis 12:521-30. 2012
    ..treatment is recommended as first-line for infants infected with HIV who have been previously exposed to nevirapine prophylaxis...
  45. ncbi Sex differences in nevirapine disposition in HIV-infected patients
    Mario Regazzi
    Departments of Pharmacology and Infectious Diseases, IRCCS Policlinico S Matteo, 27100 Pavia, Italy
    AIDS 17:2399-400. 2003
  46. ncbi Long-term efficacy and tolerance of efavirenz- and nevirapine-containing regimens in adult HIV type 1 Senegalese patients
    Pierre De Beaudrap
    Hospices Civils de Lyon, Service de Biostatistique, Lyon, F 69424, France
    AIDS Res Hum Retroviruses 24:753-60. 2008
    Owing to their low toxicity, low price, and ease of use, efavirenz (EFV) and nevirapine (NVP) are frequently used as part of antiretroviral regimens for AIDS treatment...
  47. pmc Impact of minority nonnucleoside reverse transcriptase inhibitor resistance mutations on resistance genotype after virologic failure
    Jonathan Z Li
    Division of Infectious Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Infect Dis 207:893-7. 2013
    ..In multivariable logistic regression analysis, higher NNRTI minority variant copy numbers, non-white race, and nevirapine use were associated with a higher risk of NNRTI resistance at virologic failure...
  48. ncbi HLA-Cw8 primarily associated with hypersensitivity to nevirapine
    Hiroyuki Gatanaga
    AIDS 21:264-5. 2007
  49. ncbi Voluntary counselling and testing (VCT) uptake, nevirapine use and infant feeding options at the University of Nigeria Teaching Hospital
    H E Onah
    Department of Obstetrics and Gynaecology, University of Nigeria Teaching Hospital, Enugu, Nigeria
    J Obstet Gynaecol 28:276-9. 2008
    This study assessed voluntary counselling and testing (VCT) uptake, nevirapine use and infant feeding options among the pregnant women seen in a tertiary care centre in Enugu, South-east Nigeria, with the aim of identifying gaps (if any) ..
  50. pmc Non-adherence to the single dose nevirapine regimen for the prevention of mother-to-child transmission of HIV in Bindura town, Zimbabwe: a cross-sectional analytic study
    Lazarus R Kuonza
    Department of Community Medicine, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe
    BMC Public Health 10:218. 2010
    ..In this study we determined the prevalence of and factors associated with non-adherence to the single dose nevirapine (SD-NVP) regimen for PMTCT in Bindura town.
  51. pmc Slower clearance of nevirapine resistant virus in infants failing extended nevirapine prophylaxis for prevention of mother-to-child HIV transmission
    Deborah Persaud
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    AIDS Res Hum Retroviruses 27:823-9. 2011
    b>Nevirapine resistance mutations arise commonly following single or extended-dose nevirapine (ED-NVP) prophylaxis to prevent mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV), but decay within 6-12 months of single-..
  52. ncbi Detection of minority populations of HIV-1 expressing the K103N resistance mutation in patients failing nevirapine
    Denise Lecossier
    INSERM U552, Hopital Bichat Claude Bernard, Paris, France
    J Acquir Immune Defic Syndr 38:37-42. 2005
    Salvage therapy with efavirenz is often ineffective in patients having failed nevirapine treatment, even when mutations associated with efavirenz resistance are not detected by standard population-based genotyping...
  53. ncbi Predisposition to nevirapine hypersensitivity associated with HLA-DRB1*0101 and abrogated by low CD4 T-cell counts
    Annalise M Martin
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth, Western Australia
    AIDS 19:97-9. 2005
    Genetic (human leukocyte antigen), disease-related and demographic risk factors for nevirapine reactions were examined in a nevirapine-exposed cohort...
  54. ncbi Emergence of drug-resistant HIV-1 after intrapartum administration of single-dose nevirapine is substantially underestimated
    Jeffrey A Johnson
    Laboratory Branch, National Center for HIV, STD, and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 192:16-23. 2005
    ..drug resistance mutations in approximately 40% of women shortly after they receive intrapartum single-dose nevirapine (SD-NVP)...
  55. pmc Predictors of nonadherence to single-dose nevirapine therapy for the prevention of mother-to-child HIV transmission
    Sandra Albrecht
    Gertrude H Sergievsky Center, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Acquir Immune Defic Syndr 41:114-8. 2006
    Adequate adherence is required for prevention of mother-to-child transmission of HIV (pMTCT) programs to be effective. We investigated predictors and extent of nonadherence to single-dose nevirapine.
  56. ncbi Predictors of rapid HIV testing acceptance and successful nevirapine administration in Zambian labor wards
    Karen M Megazzini
    School of Public Health, Department of Epidemiology, University of Alabama, Birmingham, AL, USA
    J Acquir Immune Defic Syndr 52:273-9. 2009
    ..Provision of HIV testing in labor provides an opportunity to reach susceptible women and infants...
  57. ncbi Improvement of mitochondrial toxicity in patients receiving a nucleoside reverse-transcriptase inhibitor-sparing strategy: results from the Multicenter Study with Nevirapine and Kaletra (MULTINEKA)
    Eugenia Negredo
    Lluita contra la SIDA Foundation, Barcelona, Spain
    Clin Infect Dis 49:892-900. 2009
    ..This study aimed to evaluate in vivo the effects of NRTI withdrawal on mitochondrial parameters and body fat distribution...
  58. ncbi Implementing a rural programme of prevention of mother-to-child transmission of HIV in Zimbabwe: first 18 months of experience
    Freddy Perez
    Institut de Santé Publique, d Epidémiologie et de Développement ISPED, Universite Victor Segalen, Bordeaux, France
    Trop Med Int Health 9:774-83. 2004
    ..To report on activities and lessons learned during the first 18 months of a rural programme of prevention of mother-to-child transmission of HIV (PMTCT) in Zimbabwe...
  59. ncbi HLA-dependent hypersensitivity to nevirapine in Sardinian HIV patients
    Roberto Littera
    Centro Regionale Trapianti, Ospedale R Binaghi, Azienda USL no 8, Cagliari, Italy
    AIDS 20:1621-6. 2006
    Hypersensitivity reaction to nevirapine, which in some cases can be fatal, shows a higher prevalence in Sardinia in comparison with other Italian regions.
  60. pmc Quantifying the metabolic activation of nevirapine in patients by integrated applications of NMR and mass spectrometries
    Abhishek Srivastava
    MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, School of Biomedical Sciences, The University of Liverpool, Liverpool, United Kingdom
    Drug Metab Dispos 38:122-32. 2010
    b>Nevirapine (NVP), an antiretroviral drug, is associated with idiosyncratic hepatotoxicity and skin reactions. Metabolic pathways of haptenation and immunotoxicity mechanisms have been proposed...
  61. pmc Antenatal couple counseling increases uptake of interventions to prevent HIV-1 transmission
    Carey Farquhar
    Department of Medicine, University of Washington, Seattle, WA 98104 249, USA
    J Acquir Immune Defic Syndr 37:1620-6. 2004
    ..b>Nevirapine was provided to HIV-1-seropositive women and condoms distributed to all participants...
  62. pmc Quantifying the impact of nevirapine-based prophylaxis strategies to prevent mother-to-child transmission of HIV-1: a combined pharmacokinetic, pharmacodynamic, and viral dynamic analysis to predict clinical outcomes
    M Frank
    Department of Clinical Pharmacy, Institute of Pharmacy, Martin Luther Universitaet Halle Wittenberg, Wolfgang Langenbeck Str 4, 06120 Halle, Germany
    Antimicrob Agents Chemother 55:5529-40. 2011
    Single-dose nevirapine (sd-NVP) and extended NVP prophylaxis are widely used in resource-constrained settings to prevent vertical HIV-1 transmission...
  63. ncbi Operational evaluation of a service for prevention of mother-to-child transmission of HIV in rural Uganda: barriers to uptake of single-dose nevirapine and the role of birth reporting
    Henry Barigye
    MRC UVRI Uganda Research Unit on AIDS, Uganda Virus Research Institute, Entebbe, Uganda
    Trop Med Int Health 15:1163-71. 2010
    To determine factors associated with pregnant women being HIV positive, barriers to the uptake of single-dose nevirapine (sdNVP) for prevention of mother-to-child transmission (PMTCT) and feasibility and effectiveness of reporting HIV-..
  64. ncbi Nevirapine for the prevention of mother-to-child transmission of HIV: a nation-wide coverage survey in Côte d'Ivoire
    Patrick A Coffie
    Programme PACCI Pôle Mère enfant, Abidjan, Cote d Ivoire
    J Acquir Immune Defic Syndr 57:S3-8. 2011
    Single-dose nevirapine (NVP) is the simplest antiretroviral regimen for the prevention of mother-to-child HIV transmission (PMTCT) in resource-limited settings...
  65. pmc Development of a liposomal nanodelivery system for nevirapine
    Lakshmi N Ramana
    Centre for Nanotechnology and Advanced Biomaterials, School of Chemical and Biotechnology, SASTRA University, Thanjavur 613 401, India
    J Biomed Sci 17:57. 2010
    ..In the present study, we have evaluated a liposome system for the delivery of nevirapine, a hydrophobic non-nucleoside reverse transcriptase inhibitor...
  66. ncbi Extended antenatal use of triple antiretroviral therapy for prevention of mother-to-child transmission of HIV-1 correlates with favorable pregnancy outcomes
    Maria C Marazzi
    LUMSA University, Rome, Italy
    AIDS 25:1611-8. 2011
    ..To evaluate pregnancy outcomes in a cohort of HIV-infected women receiving triple antiretroviral therapy (ART) for prevention of mother-to-child-transmission...
  67. doi Risk of early virological failure of once-daily tenofovir-emtricitabine plus twice-daily nevirapine in antiretroviral therapy-naive HIV-infected patients
    Giuseppe Lapadula
    Clin Infect Dis 46:1127-9. 2008
  68. pmc Constrained patterns of covariation and clustering of HIV-1 non-nucleoside reverse transcriptase inhibitor resistance mutations
    Elizabeth C Reuman
    Division of Infectious Diseases, Department of Medicine, Stanford University, 300 Pasteur Drive, Grant S 146, Stanford, CA 94305, USA
    J Antimicrob Chemother 65:1477-85. 2010
    ....
  69. ncbi Risk of side effects associated with the use of nevirapine in treatment-naïve patients, with respect to gender and CD4 cell count
    H Knobel
    Department of Internal Medicine Infectious Diseases, Hospital del Mar, Barcelona, Spain
    HIV Med 9:14-8. 2008
    A warning about the use of nevirapine (NVP) by its pharmaceutical manufacturer has been issued in which it has been recommended that NVP should not be prescribed in patients with increased risk of toxicity based on CD4 cut-offs and gender...
  70. ncbi A randomized, double-blind, placebo-controlled trial of combined nevirapine and zidovudine compared with nevirapine alone in the prevention of perinatal transmission of HIV in Zimbabwe
    Paul Thistle
    The Salvation Army Howard Hospital, Glendale, Zimbabwe
    Clin Infect Dis 44:111-9. 2007
    A single dose of nevirapine (sdNVP) administered to both mother and infant can decrease mother-to-child transmission of human immunodeficiency virus (HIV) by 47%, compared with ultra-short course zidovudine therapy (usZDV)...
  71. ncbi Analysis of RT sequences of subtype C HIV-type 1 isolates from indian patients at failure of a first-line treatment according to clinical and/or immunological WHO guidelines
    Alaka Deshpande
    ART Center and Department of Internal Medicine, Sir JJ Hospital, Byculla, Mumbai, India
    AIDS Res Hum Retroviruses 26:343-50. 2010
    ..Numerous crucial DRMs to NRTIs and NNRTIs could be recorded including TAMs of pathway 1 and K65R. According to both algorithms, the accumulation of DRMs may induce resistance to second-line NRTIs including tenofovir...
  72. pmc Incidence and risk factors of severe adverse events with nevirapine-based antiretroviral therapy in HIV-infected women. MTCT-Plus program, Abidjan, Côte d'Ivoire
    Patrick A Coffie
    Programme MTCT Plus, ACONDA, BP 1954 Abidjan 18, Abidjan, Cote d Ivoire
    BMC Infect Dis 10:188. 2010
    In resource-limited settings where nevirapine-containing regimen is the preferred regimen in women, data on severe adverse events (SAEs) according to CD4 cell count are limited...
  73. pmc Role of low-frequency HIV-1 variants in failure of nevirapine-containing antiviral therapy in women previously exposed to single-dose nevirapine
    Valerie F Boltz
    National Cancer Institute, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 108:9202-7. 2011
    In the OCTANE/A5208 study of initial antiretroviral therapy (ART) in women exposed to single-dose nevirapine (sdNVP) ≥ 6 mo earlier, the primary endpoint (virological failure or death) was significantly more frequent in the NVP-..
  74. ncbi Exposure of normal and transformed cells to nevirapine, a reverse transcriptase inhibitor, reduces cell growth and promotes differentiation
    Rosamaria Mangiacasale
    CNR, Institute of Molecular Biology and Pathology, Rome, Italy
    Oncogene 22:2750-61. 2003
    ..b>Nevirapine is a non-nucleoside RT inhibitor with a well-characterized inhibitory activity on RT enzymes of retroviral ..
  75. pmc Efavirenz versus nevirapine-based initial treatment of HIV infection: clinical and virological outcomes in Southern African adults
    Jean B Nachega
    Department of Internal Medicine and Center for Infectious Disease, Stellenbosch University, Cape Town, South Africa
    AIDS 22:2117-25. 2008
    To determine the effectiveness of efavirenz versus nevirapine in initial antiretroviral therapy regimens for adults in sub-Saharan Africa.
  76. ncbi Nevirapine versus atazanavir/ritonavir, each combined with tenofovir disoproxil fumarate/emtricitabine, in antiretroviral-naive HIV-1 patients: the ARTEN Trial
    Vicente Soriano
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    Antivir Ther 16:339-48. 2011
    ..Selection of first-line antiretroviral therapy requires consideration of efficacy as well as effects on lipids given the increased concern about cardiovascular risk in HIV-1 patients...
  77. pmc Routine versus clinically driven laboratory monitoring of HIV antiretroviral therapy in Africa (DART): a randomised non-inferiority trial
    P Mugyenyi
    MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK
    Lancet 375:123-31. 2010
    ..This trial investigated whether routine toxicity and efficacy monitoring of HIV-infected patients receiving ART had an important long-term effect on clinical outcomes in Africa...
  78. ncbi Cytochrome P450 2B6 (CYP2B6) G516T influences nevirapine plasma concentrations in HIV-infected patients in Uganda
    S R Penzak
    Clinical Pharmacokinetics Research Laboratory, National Institutes of Health, Clinical Center Pharmacy Department, Bldg 10, Room 1 N 257, Bethesda, MD 20892, USA
    HIV Med 8:86-91. 2007
    Polymorphisms in the cytochrome P450 (CYP) 2B6 gene have been shown to influence nevirapine plasma concentrations in HIV-infected European Caucasians...
  79. ncbi Antiretroviral resistance patterns and factors associated with resistance in adult patients failing NNRTI-based regimens in the Western Cape, South Africa
    Gert U van Zyl
    Division of Medical Virology, Stellenbosch University, Tygerberg, Cape Town, South Africa
    J Med Virol 83:1764-9. 2011
    ..A prolonged estimated period of failure was associated with having ≥3 TAMs. Patients treated with nevirapine (NVP) were more likely to have ETV resistance than those treated with efavirenz (EFV)...
  80. ncbi Risk of severe hepatotoxicity associated with antiretroviral therapy in the HIV-NAT Cohort, Thailand, 1996-2001
    W Phillip Law
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
    AIDS 17:2191-9. 2003
    ..To examine rates and predictors of severe hepatotoxicity with combination antiretroviral therapy in a developing country setting: the eight HIV-NAT randomized controlled trials in Thailand...
  81. pmc Safety and efficacy of nevirapine- and efavirenz-based antiretroviral treatment in adults treated for TB-HIV co-infection in Botswana
    L K Shipton
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Int J Tuberc Lung Dis 13:360-6. 2009
    The safety and efficacy of nevirapine (NVP) and efavirenz (EFV) based highly active antiretroviral treatment (ART) with concurrent anti-tuberculosis treatment in sub-Saharan Africa has not been well established.
  82. ncbi Extended antenatal antiretroviral use correlates with improved infant outcomes throughout the first year of life
    Maria C Marazzi
    Division of Infectious Diseases, David Geffen UCLA School of Medicine, Los Angeles, California 90095, USA
    AIDS 24:2819-26. 2010
    ..To evaluate the effect of extended antenatal triple antiretroviral therapy (ART) on infant outcomes...
  83. ncbi Efficacy and safety of nevirapine extended-release once daily versus nevirapine immediate-release twice-daily in treatment-naive HIV-1-infected patients
    Joseph Gathe
    Therapeutic Concepts, Houston, Texas, USA
    Antivir Ther 16:759-69. 2011
    This study (VERxVE) compared the efficacy and safety of the new nevirapine extended-release (NVP XR) formulation dosed once daily with NVP immediate release (IR) twice daily in treatment-naive patients.
  84. pmc Three generic nevirapine-based antiretroviral treatments in Chinese HIV/AIDS patients: multicentric observation cohort
    Taisheng Li
    Department of Infectious Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
    PLoS ONE 3:e3918. 2008
    The purpose of this study was to evaluate the efficacy and safety of three nevirapine-based antiretroviral treatments for adult antiretroviral-naïve Chinese patients with HIV-1 infection.
  85. ncbi Nevirapine and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis
    J P Fagot
    , , Paris France
    AIDS 15:1843-8. 2001
    ..attention to the many cases of Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) related to nevirapine detected in a multinational case-control study of SJS and TEN...
  86. pmc HIV-1 persists in breast milk cells despite antiretroviral treatment to prevent mother-to-child transmission
    Dara A Lehman
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    AIDS 22:1475-85. 2008
    ..The effects of short-course antiretrovirals given to reduce mother-to-child transmission (MTCT) on temporal patterns of cell-associated HIV-1 RNA and DNA in breast milk are not well defined...
  87. ncbi Reuse of nevirapine in exposed HIV-infected children after protease inhibitor-based viral suppression: a randomized controlled trial
    Ashraf Coovadia
    Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Johannesburg, South Africa
    JAMA 304:1082-90. 2010
    ..therapy is recommended for infants infected with human immunodeficiency virus (HIV) who were exposed to nevirapine for prevention of mother-to-child HIV transmission...
  88. pmc Persistence of nevirapine-resistant HIV-1 in women after single-dose nevirapine therapy for prevention of maternal-to-fetal HIV-1 transmission
    S Palmer
    HIV Drug Resistance Program, National Cancer Institute, National Institutes of Health, Frederick, MD 21702 1201, USA
    Proc Natl Acad Sci U S A 103:7094-9. 2006
    Single-dose nevirapine (sdNVP) for prevention of mother-to-child transmission of HIV-1 can select nevirapine (NVP)-resistant variants, but the frequency, duration, and clinical significance of this resistance is not well defined...
  89. ncbi Antiretroviral therapy in pregnant women with advanced HIV disease and pregnancy outcomes in Abidjan, Côte d'Ivoire
    Didier K Ekouevi
    ANRS 1201 1202 DITRAME PLUS Project, PACCI Collaboration, Abidjan, Cote d Ivoire, France
    AIDS 22:1815-20. 2008
    ..Pregnancy outcomes in women receiving highly active antiretroviral treatment (HAART) in Africa are not well described...
  90. ncbi Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450
    D A Erickson
    Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut 06877, USA
    Drug Metab Dispos 27:1488-95. 1999
    b>Nevirapine (NVP), a non-nucleoside inhibitor of HIV-1 reverse transcriptase, is concomitantly administered to patients with a variety of medications...
  91. ncbi Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients
    Margalida Rotger
    Institute of Microbiology and Section of Infectious Diseases, University Hospital, Lausanne, Switzerland
    Pharmacogenet Genomics 15:1-5. 2005
    Efavirenz (EFV) and nevirapine (NVP) are metabolized by cytochrome P450 2B6 (CYP2B6). Allele 516 G>T (Gln172His) is associated with diminished activity of this isoenzyme, and may lead to differences in drug exposure.
  92. pmc Field efficacy of zidovudine, lamivudine and single-dose nevirapine to prevent peripartum HIV transmission
    Francois Dabis
    Unité INSERM 593, Institut de Santé Publique, Epidémiologie et Développement ISPED, Universite Victor Segalen, 146 rue Leo Saignat, 33076 Bordeaux, France
    AIDS 19:309-18. 2005
    In Africa, single-dose nevirapine (NVPsd), short regimens of zidovudine (ZDV) or ZDV + lamivudine (3TC) are recommended to prevent peripartum mother-to-child HIV transmission (PMTCT)...
  93. pmc Rapid scaling-up of antiretroviral therapy in 10,000 adults in Côte d'Ivoire: 2-year outcomes and determinants
    Siaka Toure
    Aconda Association, Abidjan, Cote d Ivoire
    AIDS 22:873-82. 2008
    ..To assess the rates and determinants of mortality, loss to follow-up and immunological failure in a nongovernmental organization-implemented program of access to antiretroviral treatment in Côte d'Ivoire...
  94. pmc Substitution of nevirapine because of efavirenz toxicity in AIDS clinical trials group A5095
    Jeffrey T Schouten
    University of Washington, Seattle, USA
    Clin Infect Dis 50:787-91. 2010
    ..Trials Group A5095, 9% of participants who experienced an adverse event related to efavirenz substituted nevirapine. Most adverse events resolved; 15 participants ultimately discontinued nevirapine therapy...
  95. ncbi Minority quasispecies of drug-resistant HIV-1 that lead to early therapy failure in treatment-naive and -adherent patients
    Karin J Metzner
    Institute of Clinical and Molecular Virology, University of Erlangen Nuremberg, Erlangen, Germany
    Clin Infect Dis 48:239-47. 2009
    ..Therefore, we evaluated the possible role of minority quasispecies of drug-resistant human immunodeficiency virus type 1, which are undetectable at baseline by population sequencing, with regard to early virological failure...
  96. pmc Preventing mother-to-child transmission of HIV in resource-limited settings: the Elizabeth Glaser Pediatric AIDS Foundation experience
    Allison Spensley
    Elizabeth Glaser Pediatric AIDS Foundation, Santa Monica, CA, USA
    Am J Public Health 99:631-7. 2009
    ..We review 6(1/2) years of one of the world's largest programs for the prevention of mother-to-child transmission (PMTCT) of HIV...
  97. ncbi Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: 18-month follow-up of the HIVNET 012 randomised trial
    J Brooks Jackson
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Lancet 362:859-68. 2003
    In 1999, we reported safety and efficacy data for short-course nevirapine from a Ugandan perinatal HIV-1 prevention trial when 496 babies were followed up to age 14-16 weeks...
  98. ncbi Virological, immunological, and clinical impact of switching from protease inhibitors to nevirapine or to efavirenz in patients with human immunodeficiency virus infection and long-lasting viral suppression
    Eugenia Negredo
    Fundació Lluita contra la Sida, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain
    Clin Infect Dis 34:504-10. 2002
    ..infected with human immunodeficiency virus were randomized to switch from protease inhibitor (PI) therapy to nevirapine therapy (group A; n=26) or to efavirenz therapy (group B; n=25) or to continue PI therapy (group C; n=26)...
  99. ncbi Nevirapine uptake into the central nervous system of the Guinea pig: an in situ brain perfusion study
    J E Gibbs
    King s College London, Pharmaceutical Sciences Research Division, London SE1 1UL, UK
    J Pharmacol Exp Ther 317:746-51. 2006
    ..Using a well established guinea pig in situ brain perfusion model, this study investigated whether nevirapine [6H-dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one,11-cyclopropyl-5,11-dihydro-4-methyl], a non-nucleoside reverse ..
  100. pmc Association between efavirenz-based compared with nevirapine-based antiretroviral regimens and virological failure in HIV-infected children
    Elizabeth D Lowenthal
    Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    JAMA 309:1803-9. 2013
    Worldwide, the nonnucleoside reverse transcriptase inhibitors (NNRTIs) efavirenz and nevirapine are commonly used in first-line antiretroviral regimens in both adults and children with human immunodeficiency virus (HIV) infection...
  101. ncbi A cluster-randomized trial of enhanced labor ward-based PMTCT services to increase nevirapine coverage in Lusaka, Zambia
    Karen M Megazzini
    University of Alabama at Birmingham, Schools of Public Health and Medicine, Birmingham, Alabama, USA
    AIDS 24:447-55. 2010
    Determine whether enhanced labor ward-based services for prevention of mother-to-child transmission of HIV (PMTCT) would improve nevirapine (NVP) coverage.

Research Grants64

  1. Development of Transdermal Films for the the Delivery of HIV Therapeutics
    Anthony Sang Won Ham; Fiscal Year: 2010
    ..in replicate antiviral assays, indicating that it was several orders of magnitude more active against HIV-1 than nevirapine and the early NNRTIs and of similar potency to Sustiva...
  2. Antimalarial Pharmacology in HIV Coinfected Children and Pregnant Women in Uganda
    Sunil Parikh; Fiscal Year: 2013
    ..PI-based regimens include lopinavir/ritonavir, and NNRTI-based regimens include either nevirapine or efavirenz...
  3. Malaria treatment outcomes and pharmacokinetics in HIV-infected pregnant women
    MYAING MYAING NYUNT; Fiscal Year: 2010
    ..if standard doses of artemether- lumefantrine are safe and efficacious in pregnant women who are taking nevirapine-based ART for the treatment of HIV...
  4. Global HIV Drug Therapies and Mitochondrial Complications and Mechanisms
    Mariana Gerschenson; Fiscal Year: 2012
    ..n=50) compared to continuous ZDV + 3TC (n=50) or tenofovir (TDF) + emtricitabine (FTC) (n=50), all given with nevirapine (NVP) in 150 HIV+ na[unreadable]ve patients...
  5. NeuroAIDS Therapy in the EcoHIV Mouse Model
    DAVID VOLSKY; Fiscal Year: 2009
    ..reported that zalcitabine and abacavir block EcoHIV/NDK infection of mice and show in this application that nevirapine and the protease inhibitor saquinavir significantly reduce virus spread in mice...
  6. Impact of TB on Outcome of HIV in Pregnant Women
    Richard E Chaisson; Fiscal Year: 2013
    ..with the efficacy of treatment to prevent MTCT with the non-nucleoside reverse transcriptase inhibitors (NNRTIs) nevirapine and efavirenz because of upregulation of P450 cytochromes by rifampin, the key drug in TB therapy...
  7. Impact of maternal HAART on HIV-infected breastfeeding infants: Malawi
    Susan H Eshleman; Fiscal Year: 2013
    ..Most women (~70%) received single dose nevirapine (sdNVP). All infants received sdNVP and 1 week of zidovudine (control regimen)...
  8. HAART to Prevent HIV Transmission to Infants In Botswana
    Roger L Shapiro; Fiscal Year: 2010
    ..An additional group of -140 women with baseline CD4 counts <200 cells/mm3 will receive Nevirapine (NVP)/CBV for treatment, continued indefinitely...
  9. Feasibility and Cost of WHO PMTCT Option A vs. B in Rural and Urban Uganda
    Philippa Musoke; Fiscal Year: 2013
    ..Option A consists of maternal AZT prophylaxis throughout pregnancy and delivery, complemented by daily nevirapine for the infant from birth until one week after complete cessation of breastfeeding...
  10. Development of Age-Appropriate Fast Disintegrating Pediatric Granules and Tablets
    MOJI ADEYEYE; Fiscal Year: 2009
    ..FDFD) granules and tablets of fixed dose combination antiretroviral (ARV) drugs - zidovudine, lamivudine and nevirapine for the pediatric population...
  11. Plugging Hair ARV Levels as Adherence Biomarkers into HIV Prevention Trials
    Monica Gandhi; Fiscal Year: 2013
    ..Aim 2 adds hair measures for nevirapine (NVP) monitoring into the daily infant NVP prophylaxis arm of PROMISE BF (Promoting Maternal and Infant Survival ..
  12. Lopinavir/ritonavir + zidovudine to prevent perinatal HIV in Thailand
    Marc J Lallemant; Fiscal Year: 2013
    ..not need treatment for their own health receive zidovudine (ZDV) from 28 weeks'gestation, with single dose nevirapine (NVP) at onset of labor and in infants at 48-72 hours of life for the prevention of mother to child transmission ..
  13. HIV and Global Drug Therapies: Peripheral Neuropathy Complications and Mechanisms
    Cecilia M Shikuma; Fiscal Year: 2012
    ..n=50) compared to continuous ZDV + 3TC (n=50) or tenofovir (TDF) + emtricitabine (FTC) (n=50), all given with nevirapine (NVP) in ARV-naive subjects in Bangkok, Thailand...
  14. Pharmacokinetics of Anti-tuberculosis and Antiretroviral Drugs in Children
    AWEWURA JACOB KWARA; Fiscal Year: 2013
    ..TB therapy induces drug clearance substantially in young TB/HIV co-infected children resulting in reduced nevirapine exposure as compared to children receiving nevirapine therapy without anti-TB therapy...
  15. IMPACT OF INTESTINAL DYSFUNCTION ON ANTIRETROVIRAL THERAPY IN INDIA
    RITA CAROLINE ISAAC; Fiscal Year: 2012
    ..and viral resistance mutation at baseline and 12 months in a cohort of HIV seropositive individuals initiated on nevirapine based HAART...
  16. LIPOGENESIS & LIPOPROTEIN COMPLICATIONS OF HIV THERAPY
    David Y Hui; Fiscal Year: 2010
    ..In contrast, treatment that includes non-nucleoside reverse transcriptase inhibitors (NNRTI) nevirapine and efavirenz increases HDL-cholesterol...
  17. Optimal dosing of 1st line antituberculosis and antiretroviral drugs in children
    Helen McIlleron; Fiscal Year: 2013
    ..In many settings nevirapine (NVP)-based regimens remain the only effective ART available...
  18. Cellular Signaling in Drug-induced Toxicity
    NAMANDJE BUMPUS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Efavirenz (EFV) and nevirapine (NVP) are currently prescribed antiretroviral drugs of the same class that are hepatotoxic...
  19. Structure activity and structure property relationships for novel anti-HIV agents
    KATHLEEN MARY FREY; Fiscal Year: 2013
    ..Currently, there are fie FDA approved NNRTIs targeting RT, which include nevirapine, delaviridine, efavirenz, etravirine, and rilpivirine...
  20. Community Home Based India Prevention of Mother To Child Transmission study
    NISHI PADMAKAR SURYAVANSHI; Fiscal Year: 2013
    ..mothers;2) Promotion of exclusive breastfeeding for 6 months;3) Administration of six weeks extended nevirapine prophylaxis (SWEN) to all HIV-exposed infants and 4) Engagement and retention of women and infants in postpartum ..
  21. Treatment Options for Protease Inhibitor Exposed Children
    Louise Kuhn; Fiscal Year: 2013
    ..because of concerns about resistance to non-nucleoside reverse transcriptase-inhibitors (NNRTI) following use of nevirapine (NVP) in prevention of mother-to-child HIV transmission (PMTCT)...
  22. Drug-resistance testing in Kenya to improve ART suppression of HIV replication
    Lisa M Frenkel; Fiscal Year: 2013
    ..Furthermore, detection of NNRTI-resistance by OLA is highly (P<0.001) associated with virologic failure of nevirapine (NVP)-ART in two retrospective studies;one of Thai women who had been previously randomized to single-dose NVP ..
  23. A pharmacokinetic evaluation of levonorgestrel implant and antiretroviral therapy
    Kimberly K Scarsi; Fiscal Year: 2013
    ..this proposal i to conduct a PK study to evaluate the combination of a levonorgestrel (LNG) implant and NNRTI (nevirapine or efavirenz)-based ART in HIV-infected Ugandan women...
  24. Clinical Trial of CNS Penetrating ART to Prevent NeuroAIDS in China
    Scott L Letendre; Fiscal Year: 2013
    ..The primary objective will be to determine the effects of better penetrating (BP) ART (zidovudine-lamivudine-nevirapine) compared with worse penetrating (WP) ART (tenofovir-lamivudine-efavirenz) on the prevention of HAND...
  25. Lamivudine and its Impact on Perinatal HBV Transmission in HIV/HBV Coinfection
    Debika Bhattacharya; Fiscal Year: 2013
    ..In HIV, when single agent nevirapine is used for PMTCT, HIV resistance commonly occurs and is associated with HIV treatment failure in infants and ..
  26. Short Breastfeeding and Cotrimoxazole among HIV-Exposed Infants in Botswana
    Roger L Shapiro; Fiscal Year: 2013
    ..Supported feeding options will include exclusive BF + infant nevirapine prophylaxis for up to 3 months, exclusive BF + maternal HAART (if available) for up to 6 months, or FF from ..
  27. ANTIRETROVIRAL THERAPIES AND SUBSTANCE ABUSE
    David Greenblatt; Fiscal Year: 2002
    ..to determine the capacity of HIV PIs (ritonavir, nelfinavir, indinavir, saquinavir) and of NNRTls tdelavirdine, nevirapine, efavirenz) to inhibit CYP3A-mediated metabolism of methadone, buprenorphine, triazolam, alprazolam, ..
  28. CHEMISTRY SUPPORT SERVICES TO THE ETP FOR AIDS THERAPEUTICS
    Reshan Fernando; Fiscal Year: 2009
    ..UPLC, gas chromatography, elemental analysis were used to assess the purity of zivudine, lamavudine, nevirapine, and nelfinavir and begin the assessment of emtricitabine, lopinavir, ritonavir, and tenofovir...
  29. Quantification and dynamics of HIV-1 drug resistant mutants by pirosequencing
    Lisa M Frenkel; Fiscal Year: 2010
    ..Following single-dose nevirapine (sdNVP) HIV-1 resistance to NVP has been detected in 20- 69% of mothers and 46-87% of infants by consensus ..
  30. Growth Trends and Mortality Risks Among HIV-exposed Infants in Botswana
    Kathleen Powis; Fiscal Year: 2013
    ..breastfeeding is associated with favorable longitudinal growth patterns among HIV-EUIs compared with infant nevirapine prophylaxis during breastfeeding, and 5) to identify potential mediators of favorable growth patterns among HIV-..
  31. Strategies to optimize ART services for maternal&child health: the MCH-ART study
    BENAMIN LANDON MYER; Fiscal Year: 2013
    ..clinic (ANC);using an efavirenz-containing regimen that avoids the delays and toxicities associated with nevirapine;and adapting patient education to be delivered during and immediately after (rather than before) ART initiation...
  32. New Inhibitors of HIV Replication
    Gabriele Varani; Fiscal Year: 2013
    ..penetrate cellular membranes and inhibit viral replication in primary lymphocytes with activity comparable to nevirapine. We have demonstrated that the antiviral activity coincides with inhibition of both reverse transcription and ..
  33. Reservoirs of drug-resistant HIV-1
    Lisa Frenkel; Fiscal Year: 2009
    ..Single-dose nevirapine has been adopted by many programs to reduce mother-to-child transmission of HIV-1 (MTCT) due to its efficacy (50%..
  34. Resistance in HIV-infected infants after extended ARV prophylaxis: PEPI-Malawi
    Susan H Eshleman; Fiscal Year: 2010
    ..HIV transmission can be greatly reduced by providing breastfeeding infants with extended daily prophylaxis with nevirapine (NVP) or NVP plus zidovudine (ZDV)...
  35. Antiretroviral drug resistance in KwaZulu Natal
    VINCENT CHARLES MARCONI; Fiscal Year: 2013
    ..transcriptase inhibitor (NNRTI)-based regimens has not been studied except in women who received single-dose nevirapine (NVP) for prevention of mother-to-child transmission of HIV-1...
  36. ART PHARMACOKINETICS IN SEVERELY MALNOURISHED HIV-INFECTED CHILDREN
    Ericka Hayes; Fiscal Year: 2009
    ..Area under the curve pharmacokinetic measurements will be done for stavudine, lamivudine and nevirapine after 2 and 8 weeks of HAART...
  37. Optimizing NNRTI Doses in Patients with HIV and TB
    Terrence Blaschke; Fiscal Year: 2007
    ..a regimen consisting of one of the non nucleoside reverse transcriptase inhibitors (NNRTI) efavirenz (EFV) or nevirapine (NVP) plus 2 nucleoside reverse transcriptase inhibitors (NRTI), or ritonavir and/or saquinavir and 2NRTI, or a ..
  38. Optimizing Antiretroviral Therapy in HIV
    Judith S Currier; Fiscal Year: 2013
    ..based treatment to protease inhibitor therapy among women who have and have not been previously exposed to nevirapine;2) A randomized trial comparing three compact regimens for initial therapy that does not include efavirenz;3) A ..
  39. Fertility Decision-Making and Reproductive Health Outcomes in the Era of Antiretr
    SHEREE SCHWARTZ; Fiscal Year: 2009
    ..to compare incidence rates of pregnancy between women on ART regimens that use the drug efavirenz versus nevirapine as a non- nucleoside reverse transcriptase inhibitor (NNRTI)...
  40. HIV-1 chemoprophylaxis and archived drug resistance in infants
    Deborah Persaud; Fiscal Year: 2010
    ..progression and mortality, but in low-income countries often the only HAART option is combination therapy with nevirapine (NVP)...
  41. HAART Regimens in Substance Abusers
    David Greenblatt; Fiscal Year: 2003
    ..CYP3A and P-gp inhibition and induction with initial and extended exposure to ritonavir, delavirdine, and nevirapine. Cell culture models will assess P-gp mediated transport of various psychotropic drugs, potentially abusable ..
  42. Sustained release depot pre-exposure prophylaxis in breast feeding populations
    Thomas Smith; Fiscal Year: 2007
    ..reduced through relatively simple expedients such as dosing mother and child around the time of delivery with nevirapine. However breast feeding still accounts for approximately 315,000 cases annually of pediatric AIDS in sub-Saharan ..
  43. VERTICAL TRANSMISSION OF SUBTYPE C HIV IN ZIMBABWE
    David Katzenstein; Fiscal Year: 2001
    ..HIV seropositive pregnant women will receive peripartum treatment with either zidovudine (200) or single dose nevirapine (163). However the rate of transmission is still estimated to exceed 15 percent...
  44. DIOXOLANE NUCLEOSIDES AS ANTIVIRAL AGENTS
    Jinfa Du; Fiscal Year: 2003
    ..04, mu M) without producing cross-resistance with 3TC, AZT or nevirapine. D-FDOC is also effective against HBV in culture...
  45. HIV PREVENTION TRIALS UNIT-THAILAND
    David Celentano; Fiscal Year: 2006
    ..g. nevirapine and AZT) or other promising compounds, as recommended by the PTN's Perinatal Working Group...
  46. SUSTAINED HIV1 SUPPRESSION DESPITE DRUG RESISTANCE
    Victoria Johnson; Fiscal Year: 2000
    ..in some HIV-1-infected individuals treated with a combined zidovudine (ZDV) plus either lamivudine (3TC) or nevirapine (NVP)...
  47. Development of Pyrimidinedione NNRTIs With a High Genetic Barrier to Resistance
    Robert Buckheit; Fiscal Year: 2009
    Although the currently approved NNRTIs (nevirapine, delavirdine, efavirenz, etrivirine) are highly potent, significant improvements in therapeutic utility are still required...
  48. Prevention of HIV resistance to nevirapine in pregnancy
    Lisa Frenkel; Fiscal Year: 2003
    This research will be done primarily in Peru as an extension of NIH grant #5 R0l HD36184. Widespread use of nevirapine chemoprophylaxis has been implemented to achieve moderately effective reduction of peripartum HIV- 1 transmission at a ..
  49. NUCLEOSIDES WITH DUAL ANTIHIV AND HBV ACTIVITY
    RAYMOND SCHINAZI; Fiscal Year: 1999
    ..ddI, ddC, a protease inhibitor such as indinavir, and a nonnucleoside reverse transcriptase inhibitor, such as nevirapine. Moreover, the relative rate for the emergence of resistance to D-D4FC will be determined and compared with 3TC [..
  50. ZIDOVUDINE AT BIRTH TO REDUCE PERINATAL HIV TRANSMISSION
    Taha Taha; Fiscal Year: 2004
    ..A more practical and less expensive regimen on nevirapine (NVP) intrapartum to the mother and to the neonate reduced MTCT of HIV by about 50% in a breastfeeding ..
  51. Reservoirs of drug-resistant HIV-1
    Lisa Frenkel; Fiscal Year: 2004
    ..The persistence of nevirapine-resistant viral variants in infants who are infected during chemoprophylaxis (most likely with drug-resistant ..
  52. THE ZIMBABWE-SAN FRANCISCO HIV PREVENTION TRIALS UNIT
    Tsungai Chipato; Fiscal Year: 2006
    ..standard counseling and testing among high-risk MSM; and HIVNET 023, an international safety and dosing study of nevirapine for post-natal prevention of HIV transmission...
  53. ZDV USE TO PREVENT MATERNAL/INFANT HIV TRANSMISSION
    Andrea Ruff; Fiscal Year: 2007
    ..underway in Kampala, Uganda and Pune, India will evaluate the efficacy of a 6 week prophylactic regimen of nevirapine in the prevention of HIV transmission among breastfed infants...
  54. Prevention of Milk-Borne Transmission of HIV in Bostwana
    Myron Essex; Fiscal Year: 2004
    ..objectives of the Mother / Infant ("Mashi") study are: i) To determine whether single-dose maternal and infant nevirapine (NVP, per HIVNET 012 protocol) prevents additional MTCT when added to short-course zidovudine (ZDV, starting at ..
  55. Nevirapine Resistance in Women who Received Nevirapine for PMTCT HIV
    Christopher Rowley; Fiscal Year: 2009
    ..hypothesis to be examined is that more sensitive assays can detect viral resistance in women who have received nevirapine for the prevention of mother-to-child transmission (PMTCT) and that this information can predict clinical ..
  56. MU-JHU HPTU TRIAL SITE - UGANDA
    Laura Guay; Fiscal Year: 2006
    ..intervention trials in Uganda involving more than 1500 mother-infant pairs, including the HIVNET 006 Phase I/II nevirapine trial, the HIVNET 012 Phase IIB nevirapine/zidovudine trial, the UNAIDS Phase III PETRA trial, and the Phase I/..
  57. SOUTH AFRICA MRC HIV PREVENTION TRIALS UNIT
    Gita Ramjee; Fiscal Year: 2006
    ..focuses on breastfeeding transmission, and new interventions are being assessed including the extended use of nevirapine as prophylaxis during breastfeeding...
  58. Prevention of HIV Transmission in Breast Feeding Populations
    Thomas Smith; Fiscal Year: 2005
    ..reduced through relatively simple expedients such as dosing mother and child around the time of delivery with nevirapine. However breast feeding still accounts for approximately 315,000 cases annually of pediatric AIDS in sub- ..
  59. MALARIA AND HIV IN PREGNANT WOMEN IN MALAWI
    Steven Meshnick; Fiscal Year: 2005
    Approximately 500,000 HIV-infected children are born each year in sub-Saharan Africa. Nevirapine treatment programs could prevent about half of these infections. In Arica, maternal malaria is common and frequently causes low birth weight...
  60. A Training Program in International Women's Health
    BENJAMIN CHI; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Peripartum nevirapine (NVP) is an important and effective intervention for perinatal HIV prevention in resource-constrained settings...
  61. ARV effects on HIV epidemiology and behaviors in Rakai, Uganda
    Maria Wawer; Fiscal Year: 2009
    ..is also needed on the emergence and transmission of drug resistance mutations, the effects of prior maternal nevirapine use on subsequent ARV effectiveness, and on barriers to ARV acceptance and adherence...
  62. Immunization by HIV exposure during chemoprophylaxis
    Lisa Frenkel; Fiscal Year: 2006
    ..strategy we propose a pilot study of specimens collected as part of a protocol defining the pharmacokinetics of nevirapine chemoprophylaxis during birth and breastfeeding (HIVNET 023)...
  63. Feasibility of CCR5 Inhibitors in Preventing Maternal to Infant SIV Transmission
    Nancy Shulman; Fiscal Year: 2009
    ..Although single dose nevirapine prophylaxis given to the mother during labor and to the baby after birth has prevented many perinatal infections,..
  64. Drug Resistance in Non-Subtype B HIV-1
    Susan Eshleman; Fiscal Year: 2005
    ..will be performed in the context of the Ugandan HIVNET 012 trial, which demonstrated that single dose nevirapine (NVP) prophylaxis can prevent HIV-1 mother-to-child transmission...