pempidine

Summary

Summary: A nicotinic antagonist most commonly used as an experimental tool. It has been used as a ganglionic blocker in the treatment of hypertension but has largely been supplanted for that purpose by more specific drugs.

Top Publications

  1. ncbi Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine
    T J Martin
    Department of Pharmacology and Toxicology, Medical College of Virginia Virginia Commonwealth University, Richmond
    J Pharmacol Exp Ther 254:45-51. 1990
  2. pmc Distinct presynaptic control of dopamine release in striosomal- and matrix-enriched areas of the rat striatum by selective agonists of NK1, NK2, and NK3 tachykinin receptors
    L Tremblay
    Laboratoire de Neuropharmacologie, Institut National de la Santé et de la Recherche Médicale Unité 114, College de France, Paris, France
    Proc Natl Acad Sci U S A 89:11214-8. 1992
  3. ncbi Mathematical assessment of qualitative diagnostic calibration for respiratory inductive plethysmography
    A De Groote
    Biomedical Physics Laboratory, Universite Libre de Bruxelles, 1070 Brussels, Belgium
    J Appl Physiol (1985) 90:1025-30. 2001
  4. ncbi Understanding channel blocking in the nicotinic acetylcholine receptor
    M O Ortells
    Instituto de Investigaciones Bioquímicas CONICET, CC 857, 8000 Bahia Blanca, Argentina
    Receptors Channels 7:273-88. 2001
  5. ncbi Images in clinical medicine. Massive air embolism in a neonate with pulmonary hypoplasia
    Gim H Tan
    Miami Children s Hospital, Miami, FL 33155, USA
    N Engl J Med 346:751. 2002
  6. ncbi Comparison of three nonlinear and spline regression models for describing chicken growth curves
    S E Aggrey
    Poultry Genetics and Biotechnology Laboratory, Department of Poultry Science, The University of Georgia, Athens, Georgia 30602 2772, USA
    Poult Sci 81:1782-8. 2002
  7. ncbi Dronedarone for prevention of atrial fibrillation: a dose-ranging study
    Paul Touboul
    Division of Cardiology, Hopital Cardiologique, Lyon, France
    Eur Heart J 24:1481-7. 2003
  8. ncbi Late-onset ureteric urinoma with intermittent jet flow as a complication of ureterolithotomy
    Birsen Unal
    Department of Radiology, Kirikkale University School of Medicine, , Kirikkale, Turkey
    J Clin Ultrasound 32:264-6. 2004
  9. ncbi Racial differences in adipocyte size and relationship to the metabolic syndrome in obese women
    Thomas J Tittelbach
    Baltimore VA Medical Center, Geriatric Research, Education, and Clinical Center BT GR 18, 10 N Greene Street, MD 21201, USA
    Obes Res 12:990-8. 2004
  10. ncbi Comparison of outcomes between Burch colposuspension with and without concomitant abdominal hysterectomy
    Sang Wook Bai
    Department of Obstetrics and Gynecology, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul 120 752, Korea
    Yonsei Med J 45:665-70. 2004

Scientific Experts

  • C Bolm
  • Hervé J Brisse
  • T J Tittelbach
  • S E Aggrey
  • Anne De Groote
  • Dean Myers
  • S W Bai
  • Marcelo O Ortells
  • G A Buznikov
  • Meghan J McFadden
  • Tomoshige Hayashi
  • Birsen Unal
  • Paul Touboul
  • Gim H Tan
  • A De Groote
  • John D Brennan
  • Murray S Junop
  • V E Gmiro
  • Marguerite J McNeely
  • Edward J Boyko
  • Steven E Kahn
  • Wilfred Y Fujimoto
  • Donna L Leonetti
  • D X Wang
  • Simay Kara
  • Halil Basar
  • Murat Basar
  • Ertan Batislam
  • Miyace Y Karadeniz Bilgili
  • Alessandro Capucci
  • Nils Edvardsson
  • Harry J G M Crijns
  • Stefan H Hohnloser
  • Josep Brugada
  • K M Sándorné
  • G I Wilkie
  • Jeffrey B Sussmane
  • Y Verbandt
  • M Paiva
  • S E Serdiuk
  • M L Kemel
  • L G Abood
  • S S Sheu
  • V K Sharma
  • M Journet
  • A S Kende
  • L Rubin
  • J P Sullivan
  • P Hutson
  • S Wonnacott
  • G Blazso
  • J Glowinski
  • C Gauchy
  • M Desban
  • L Tremblay
  • C Maccarrone
  • H Haikala
  • L D Snell
  • D Rotiroti
  • J L Maderdrut
  • T J Martin
  • B R Martin
  • G P Germana
  • F Naccari
  • J Suchocki
  • B Jarrott
  • E Ciriaco
  • L Ahtee
  • E L May
  • D Ammendola
  • G Germana
  • K M Johnson
  • R W Oppenheim
  • D Prevette

Detail Information

Publications27

  1. ncbi Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine
    T J Martin
    Department of Pharmacology and Toxicology, Medical College of Virginia Virginia Commonwealth University, Richmond
    J Pharmacol Exp Ther 254:45-51. 1990
    The nature of mecamylamine's and pempidine's antagonism of nicotine in the central nervous system has not been defined clearly...
  2. pmc Distinct presynaptic control of dopamine release in striosomal- and matrix-enriched areas of the rat striatum by selective agonists of NK1, NK2, and NK3 tachykinin receptors
    L Tremblay
    Laboratoire de Neuropharmacologie, Institut National de la Santé et de la Recherche Médicale Unité 114, College de France, Paris, France
    Proc Natl Acad Sci U S A 89:11214-8. 1992
    ....
  3. ncbi Mathematical assessment of qualitative diagnostic calibration for respiratory inductive plethysmography
    A De Groote
    Biomedical Physics Laboratory, Universite Libre de Bruxelles, 1070 Brussels, Belgium
    J Appl Physiol (1985) 90:1025-30. 2001
    ..More generally, physiological conclusions based on QDC should be critically evaluated on a case-by-case basis...
  4. ncbi Understanding channel blocking in the nicotinic acetylcholine receptor
    M O Ortells
    Instituto de Investigaciones Bioquímicas CONICET, CC 857, 8000 Bahia Blanca, Argentina
    Receptors Channels 7:273-88. 2001
    ..This represents a strong support for the validity of the predictions made for those molecules for which no experimental data is available and also for the models and methods on which are based...
  5. ncbi Images in clinical medicine. Massive air embolism in a neonate with pulmonary hypoplasia
    Gim H Tan
    Miami Children s Hospital, Miami, FL 33155, USA
    N Engl J Med 346:751. 2002
  6. ncbi Comparison of three nonlinear and spline regression models for describing chicken growth curves
    S E Aggrey
    Poultry Genetics and Biotechnology Laboratory, Department of Poultry Science, The University of Georgia, Athens, Georgia 30602 2772, USA
    Poult Sci 81:1782-8. 2002
    ..Carcass yields among the different growth trajectories (m) were similar within sexes. However, the proportions of the major breast muscle and abdominal fat differed according to the m a bird followed...
  7. ncbi Dronedarone for prevention of atrial fibrillation: a dose-ranging study
    Paul Touboul
    Division of Cardiology, Hopital Cardiologique, Lyon, France
    Eur Heart J 24:1481-7. 2003
    ..This study was designed to determine the most appropriate dose of dronedarone for prevention of atrial fibrillation (AF) after cardioversion...
  8. ncbi Late-onset ureteric urinoma with intermittent jet flow as a complication of ureterolithotomy
    Birsen Unal
    Department of Radiology, Kirikkale University School of Medicine, , Kirikkale, Turkey
    J Clin Ultrasound 32:264-6. 2004
    ..The urinoma was surgically resected and ureteroneocystostomy was performed...
  9. ncbi Racial differences in adipocyte size and relationship to the metabolic syndrome in obese women
    Thomas J Tittelbach
    Baltimore VA Medical Center, Geriatric Research, Education, and Clinical Center BT GR 18, 10 N Greene Street, MD 21201, USA
    Obes Res 12:990-8. 2004
    ..To determine whether racial differences exist in the relationship of the abnormalities defining the metabolic syndrome (MS) to regional adiposity and fat cell size (FCS) in obese postmenopausal women...
  10. ncbi Comparison of outcomes between Burch colposuspension with and without concomitant abdominal hysterectomy
    Sang Wook Bai
    Department of Obstetrics and Gynecology, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul 120 752, Korea
    Yonsei Med J 45:665-70. 2004
    ..2% (73/80) in the hysterectomy groups. The results showed that there were no adverse effects on the 1 year follow-up outcomes or complications in patients who underwent a Burch colposuspension with an abdominal hysterectomy...
  11. ncbi Corticosterone implants to the amygdala and type 1 CRH receptor regulation: effects on behavior and colonic sensitivity
    Dean A Myers
    Department of Obstetrics and Gynecology, Oklahoma University Health Sciences Center, Oklahoma City, OK 73014, USA
    Behav Brain Res 161:39-44. 2005
    ..These results provide further evidence for the role of the CRH type 1 receptor to ameliorate both behavioral and physiological functions...
  12. ncbi Visceral adiposity, not abdominal subcutaneous fat area, is associated with an increase in future insulin resistance in Japanese Americans
    Tomoshige Hayashi
    Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System S 152E, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes 57:1269-75. 2008
    ..We sought to determine whether greater visceral adiposity directly measured by computed tomography (CT) is associated with increased future insulin resistance independent of other adipose depots...
  13. ncbi The relevance of image quality indices for dose optimization in abdominal multi-detector row CT in children: experimental assessment with pediatric phantoms
    H J Brisse
    Imaging Department, Institut Curie, 26 rue d Ulm 75005 Paris, France
    Phys Med Biol 54:1871-92. 2009
    ..g., to get a constant 7 mm rLCD(1%) for abdominal diameters of 10, 13, 16, 20 and 25 cm, tube current-time product should be adjusted in order to obtain CTDIvol(16) values of 6.2, 7.2, 8.8, 11.6 and 17.7 mGy, respectively)...
  14. ncbi Practical and highly enantioselective ring opening of cyclic meso-anhydrides mediated by cinchona alkaloids
    C Bolm
    Institut fur Organische Chemie der RWTH Aachen, Prof Pirlet Strasse 1, D 52056 Aachen, Germany
    J Org Chem 65:6984-91. 2000
    ..Additionally, a catalytic protocol which permits the substoichiometric use of quinidine in the presence of easily accessible pentamethylpiperidine (pempidine) is presented.
  15. ncbi [A comparative study of the central H-cholinergic-blocking and NMDA-blocking actions of MK-801, memantin, amantadine, pyrilen and IEM-1754 in experiments on intact rats]
    V E Gmiro
    Anichkov Department of Neuropharmacology, Russian Academy of Medical Sciences, St Petersburg, Russia
    Eksp Klin Farmakol 63:16-20. 2000
    ....
  16. ncbi Functional heterogeneity of the matrix compartment in the cat caudate nucleus as demonstrated by the cholinergic presynaptic regulation of dopamine release
    M L Kemel
    College de France, INSERM U114, Paris, France
    Neuroscience 50:597-610. 1992
    ..stimulation of [3H]dopamine release was transformed into a long-lasting response in the presence of pempidine (50 microM), in matrix 2 but not in matrix 1 while prolonged responses were seen in both matrix areas in the ..
  17. ncbi Ultrastructural changes of crop-sac and lactotrophs after systemic or intraventricular administration of drugs enhancing cholinergic transmission in pigeons
    D Rotiroti
    Institute of Veterinary Pharmacology, Faculty of Veterinary Medicine, University of Messina, Italy
    Anat Anz 173:199-208. 1991
    ..lactotrophs stimulatory effects were prevented by an atropine pretreatment, but not by mecamylamine and pempidine pretreatments...
  18. ncbi Effects of nicotinic agonists and antagonists on N-methyl-D-aspartate-induced 3H-norepinephrine release and 3H-(1-[1-(2-thienyl)cyclohexyl]-piperidine) binding in rat hippocampus
    L D Snell
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston 77550
    Synapse 3:129-35. 1989
    ..Binding studies indicated that MECA and the related nicotinic antagonist pempidine produced an inhibition of NMDA-stimulated NE release by an action at the PCP receptor that is known to be linked ..
  19. pmc Distinct presynaptic control of dopamine release in striosomal and matrix areas of the cat caudate nucleus
    M L Kemel
    Laboratoire de Neuropharmacologie, College de France, Paris
    Proc Natl Acad Sci U S A 86:9006-10. 1989
    ..The latter effect was completely abolished by the nicotinic antagonist pempidine (10(-5) M)...
  20. ncbi Enhancement of naturally occurring cell death in the sympathetic and parasympathetic ganglia of the chicken embryo following blockade of ganglionic transmission
    J L Maderdrut
    Department of Anatomy, Bowman Gray School of Medicine, Winston Salem, NC 27103
    Brain Res 444:189-94. 1988
    ..These results indicate that the decreased number of healthy ganglion cells that followed ganglionic blockade was the result of enhanced naturally occurring cell death...
  21. ncbi Surgical and pharmacological reductions in sympathetic nerve activity increase the neuropeptide Y-immunoreactivity content of the rat iris but not the vas deferens
    C Maccarrone
    University of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australia
    Life Sci 42:2633-8. 1988
    ..the iris was increased by decentralization (+40%) 3 days post-surgery, and treatment with clonidine (+43%), and pempidine (+82%)...
  22. ncbi Antagonism of the nicotine-induced changes of the striatal dopamine metabolism in mice by mecamylamine and pempidine
    H Haikala
    University of Helsinki, Department of Pharmacy, Finland
    Naunyn Schmiedebergs Arch Pharmacol 338:169-73. 1988
    The ability of nicotinic receptor blockers, mecamylamine and pempidine, to antagonize the changes in striatal dopamine (DA) metabolism induced by repeated nicotine administration was studied...
  23. ncbi Pharmacological characterization of a nicotinic autoreceptor in rat hippocampal synaptosomes
    G I Wilkie
    School of Biology and Biochemistry, University of Bath, United Kingdom
    Neurochem Res 21:1141-8. 1996
    ..was Ca(2+)-dependent, and blocked by the nicotinic antagonists dihydro-beta-erythroidine, mecamylamine, and pempidine. The alpha 7-selective antagonist methyllycaconitine did not inhibit nicotine-evoked release when tested at 1 ..
  24. ncbi [3H]benzylpempidine, a new radioligand for probing a putative channel site on nicotinic cholinergic receptors
    D X Wang
    Department of Pharmacology and Physiology, University of Rochester Medical Center, NY 14642, USA
    Life Sci 60:1271-7. 1997
    ..Although the K(i) values for pempidine and mecamylamine were 1-2 orders of magnitude greater than any of the arylpempidines, the dose required to ..
  25. ncbi Nicotinic antagonists (piperidines and quinuclidines) reduce the susceptibility of early sea urchin embryos to agents evoking calcium shock
    G A Buznikov
    N K Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia
    Gen Pharmacol 29:49-53. 1997
    ..3. Early sea urchin embryos have nicotinic acetylcholine receptors (nAChR) or nAChR-like structures localized on the cell surface that, apparently, take part in the control of Ca2+ influx...
  26. ncbi [Effects of drugs on re-excitability of synapses of isolated frog ganglia]
    K M Sándorné
    Szent Gyórgyi Albert Orvostudományi Egyetem Gyógyszerhatástani Intézete, Szeged
    Acta Pharm Hung 66:259-64. 1996
    ..Using paired stimulation we demonstrated that hexamethonium, magnesium, pempidine, tetraethylammonium (TEA) and d-tubocurarine chlorides significantly prolonged both NEP and REP at ganglion ..
  27. ncbi Magnetic "fishing" assay to screen small-molecule mixtures for modulators of protein-protein interactions
    Meghan J McFadden
    Chemical Biology Graduate Program, Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4M1, Canada
    Anal Chem 82:9850-7. 2010
    ..activity, and two newly identified modulators of the CaM-Mel interaction, methylbenzethonium and pempidine tartrate...