Genomes and Genes
Summary: A central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE.
Publications333 found, 100 shown here
- The epidemiology of pharmacologically treated attention deficit hyperactivity disorder (ADHD) in children, adolescents and adults in UK primary careSuzanne McCarthy
School of Pharmacy, University College Cork, Cork, Ireland
BMC Pediatr 12:78. 2012..5-4%. Few data exist on the prescribing trends of the stimulants methylphenidate and dexamfetamine, and the non-stimulant atomoxetine in the UK...
- Efficacy of methylphenidate for adults with attention-deficit hyperactivity disorder: a meta-regression analysisXavier Castells
Psychiatry Department, Hospital Universitari Vall dHebron, Barcelona, Spain
CNS Drugs 25:157-69. 2011The efficacy of methylphenidate for adults with attention-deficit hyperactivity disorder (ADHD) shows wide between-study variability, which yields heterogeneous results in meta-analysis...
- Methylphenidate normalises activation and functional connectivity deficits in attention and motivation networks in medication-naïve children with ADHD during a rewarded continuous performance taskKatya Rubia
Department of Child Psychiatry, Institute of Psychiatry, King s College, London, UK
Neuropharmacology 57:640-52. 2009..ADHD) have deficits in motivation and attention that can be ameliorated with the indirect dopamine agonist Methylphenidate (MPH)...
- Once-a-day Concerta methylphenidate versus three-times-daily methylphenidate in laboratory and natural settingsW E Pelham
Department of Psychology, State University of New York at Buffalo, Buffalo, New York, USA
Pediatrics 107:E105. 2001b>Methylphenidate (MPH), the most commonly prescribed drug for attention-deficit/hyperactivity disorder (ADHD), has a short half-life, which necessitates multiple daily doses...
- Modafinil and methylphenidate for neuroenhancement in healthy individuals: A systematic reviewDimitris Repantis
Department of Psychiatry, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, 14050 Berlin, Germany
Pharmacol Res 62:187-206. 2010..Of known interventions, psychopharmacology provides readily available options, such as methylphenidate and modafinil. Both drugs are presumed to be in widespread use as cognitive enhancers for non-medical reasons...
- Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorderNora D Volkow
National Institute on Drug Abuse, 6001 Executive Blvd, Room 5274, Bethesda, MD 20892, USA
Arch Gen Psychiatry 64:932-40. 2007..There is considerable evidence that brain dopamine is involved in ADHD, but it is unclear whether dopamine activity is enhanced or depressed...
- Misuse and diversion of stimulants prescribed for ADHD: a systematic review of the literatureTimothy E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 47:21-31. 2008..The purpose of this systematic review of the literature is to evaluate the extent and characteristics of stimulant misuse and diversion in attention-deficit/hyperactivity disorder (ADHD) and non-ADHD individuals...
- Non-medical use of prescription stimulants among US college students: prevalence and correlates from a national surveySean Esteban McCabe
University of Michigan, Substance Abuse Research Center, Ann Arbor, MI 48105, USA
Addiction 100:96-106. 2005..To examine the prevalence rates and correlates of non-medical use of prescription stimulants (Ritalin, Dexedrine or Adderall) among US college students in terms of student and college characteristics...
- Methylphenidate enhances brain activation and deactivation responses to visual attention and working memory tasks in healthy controlsD Tomasi
National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
Neuroimage 54:3101-10. 2011b>Methylphenidate (MPH) is a stimulant drug that amplifies dopamineric and noradrenergic signaling in the brain, which is believed to underlie its cognition enhancing effects...
- Methylphenidate normalizes fronto-striatal underactivation during interference inhibition in medication-naïve boys with attention-deficit hyperactivity disorderKatya Rubia
Department of Child Psychiatry, Institute of Psychiatry, King s College London, London, UK
Neuropsychopharmacology 36:1575-86. 2011..have deficits in interference inhibition, which can be improved with the indirect catecholamine agonist methylphenidate (MPH)...
- Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjectsN D Volkow
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
Nature 386:830-3. 1997..emission tomography (PET) to compare the responses of cocaine addicts and normal controls to intravenous methylphenidate, a drug that, like cocaine, causes an increase in synaptic dopamine...
- Illicit use of specific prescription stimulants among college students: prevalence, motives, and routes of administrationChristian J Teter
School of Pharmacy, Northeastern University, Boston, Massachusetts, USA
Pharmacotherapy 26:1501-10. 2006..To explore the illicit use of specific prescription stimulants among college students and add to our understanding of reasons (motives) and routes of administration associated with illicit use of these drugs...
- Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memoryPhilip L Clatworthy
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
J Neurosci 29:4690-6. 2009Previous data suggest that methylphenidate can have variable effects on different cognitive tasks both within and between individuals...
- Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidateN D Volkow
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Am J Psychiatry 155:1325-31. 1998The therapeutic effects of methylphenidate in the treatment of attention deficit disorder have been attributed to its ability to increase the synaptic concentration of dopamine by blocking the dopamine transporters...
- Dissociable effects of methylphenidate, atomoxetine and placebo on regional cerebral blood flow in healthy volunteers at rest: a multi-class pattern recognition approachAndre F Marquand
Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, UK
Neuroimage 60:1015-24. 2012The stimulant drug methylphenidate (MPH) and the non-stimulant drug atomoxetine (ATX) are both widely used for the treatment of attention deficit/hyperactivity disorder (ADHD), but their differential effects on human brain function are ..
- Methylphenidate-elicited dopamine increases in ventral striatum are associated with long-term symptom improvement in adults with attention deficit hyperactivity disorderNora D Volkow
National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
J Neurosci 32:841-9. 2012Stimulant medications, such as methylphenidate, which are effective treatments for attention deficit hyperactivity disorder (ADHD), enhance brain dopamine signaling...
- Methylphenidate effects on prefrontal functioning during attentional-capture and response inhibitionAstrid M Pauls
Department of Neuroimaging, Institute of Psychiatry, King s College London, United Kingdom
Biol Psychiatry 72:142-9. 2012b>Methylphenidate improves motor response inhibition, typically assessed with the stop-signal task. The exact underlying mechanism for this, however, remains unknown...
- Pharmacokinetic variability of long-acting stimulants in the treatment of children and adults with attention-deficit hyperactivity disorderJames C Ermer
Clinical Pharmacology and Pharmacokinetics, Shire Development Inc, Wayne, Pennsylvania, USA
CNS Drugs 24:1009-25. 2010b>Methylphenidate- and amfetamine-based stimulants are first-line pharmacotherapies for attention-deficit hyperactivity disorder, a common neurobehavioural disorder in children and adults...
- Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brainN D Volkow
Departments of Medical and Chemistry, Brookhaven National Laboratory, Upton, New York 11973, USA
J Neurosci 21:RC121. 2001b>Methylphenidate (Ritalin) is the most commonly prescribed psychoactive drug in children for the treatment of attention deficit hyperactivity disorder (ADHD), yet the mechanisms responsible for its therapeutic effects are poorly ..
- Differential effects of methylphenidate on problem solving in adults with ADHDLara Tucha
Department of Psychology, Faculty of Behavioural and Social Sciences, University of Groningen, Grote Kruisstraat 2 1, 9712 TS Groningen, Netherlands
J Atten Disord 15:161-73. 2011..Two studies were performed to assess both divergent and convergent thinking in adults with ADHD...
- Pharmacogenetic predictors of methylphenidate dose-response in attention-deficit/hyperactivity disorderTanya E Froehlich
University of Cincinnati College of Medicine and Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Am Acad Child Adolesc Psychiatry 50:1129-1139.e2. 2011..This study examined the role of four catecholamine-related candidate genes in moderating methylphenidate (MPH) dose-response.
- Short-term cardiovascular effects of methylphenidate and adderallR L Findling
Department of Psychiatry and Pediatrics, University Hospitals of Cleveland, Case Western Reserve University, OH 44106-5080, USA
J Am Acad Child Adolesc Psychiatry 40:525-9. 2001..METHOD: One hundred thirty-seven patients were treated with either methylphenidate (MPH) or ADL...
- The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistryT W Robbins
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Psychopharmacology (Berl) 163:362-80. 2002..The developmental history and application of the 5-choice serial reaction time task (5CSRTT) for measuring effects of drugs and other manipulations on attentional performance (and stimulus control) in rats is reviewed...
- Attention deficit hyperactivity disorder in adultsMichael Rösler
Neurozentrum, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
World J Biol Psychiatry 11:684-98. 2010..To examine available literature regarding attention deficit hyperactivity disorder (ADHD) in adults...
- Mortality associated with attention-deficit hyperactivity disorder (ADHD) drug treatment: a retrospective cohort study of children, adolescents and young adults using the general practice research databaseSuzanne McCarthy
Centre for Paediatric Pharmacy Research, The School of Pharmacy, University of London and the Institute of Child Health, University College London, London, UK
Drug Saf 32:1089-96. 2009....
- A dose-response study of OROS methylphenidate in children with attention-deficit/hyperactivity disorderMark A Stein
Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
Pediatrics 112:e404. 2003OROS methylphenidate HCL (MPH) is a recently developed long-acting stimulant medication used to treat attention-deficit/hyperactivity disorder (ADHD)...
- Psychostimulant treatment and the developing cortex in attention deficit hyperactivity disorderPhilip Shaw
Child Psychiatry Branch, Bldg 10, Center Dr, NIMH, Bethesda, MD 20892, USA
Am J Psychiatry 166:58-63. 2009..The authors sought to determine prospectively whether psychostimulant treatment for attention deficit hyperactivity disorder (ADHD) was associated with differences in the development of the cerebral cortex during adolescence...
- Task-related default mode network modulation and inhibitory control in ADHD: effects of motivation and methylphenidateElizabeth B Liddle
University of Nottingham, Nottingham, UK
J Child Psychol Psychiatry 52:761-71. 2011..We also hypothesised that methylphenidate, an indirect dopamine agonist, would tend to normalise abnormal patterns of DMN deactivation.
- Attention-deficit hyperactivity disorder: treatment discontinuation in adolescents and young adultsSuzanne McCarthy
Centre for Paediatric Pharmacy Research, School of Pharmacy, University of London and Institute of Child Health, University College London, UK
Br J Psychiatry 194:273-7. 2009..Symptoms of attention-deficit hyperactivity disorder (ADHD) are known to persist into adulthood in the majority of cases...
- Methylphenidate improves working memory and set-shifting in AD/HD: relationships to baseline memory capacityMitul A Mehta
University of Cambridge, Department of Psychiatry, UK
J Child Psychol Psychiatry 45:293-305. 2004..Clear delineation of the effects of methylphenidate upon such cognitive functions in AD/HD would enhance understanding of the effects of drug treatment.
- Review of medication adherence in children and adults with ADHDLisa D Adler
Cornell University, Ithaca, NY, USA
Postgrad Med 122:184-91. 2010..To review the literature on the prevalence, potential causes, and consequences of medication nonadherence in adult attention-deficit/hyperactivity disorder (ADHD)...
- Sub-optimal performance in the 5-choice serial reaction time task in rats was sensitive to methylphenidate, atomoxetine and d-amphetamine, but unaffected by the COMT inhibitor tolcaponeNeil E Paterson
Behavioral Pharmacology, PsychoGenics, Inc, Tarrytown, NY 10591, USA
Neurosci Res 69:41-50. 2011..5-2.0 mg/kg), the mixed DA/NE reuptake inhibitor methylphenidate (0.1-2.0 mg/kg), the catecholamine releaser D-amphetamine (0.1-1...
- A randomized, controlled effectiveness trial of OROS-methylphenidate compared to usual care with immediate-release methylphenidate in attention deficit-hyperactivity disorderMargaret Steele
Department of Psychiatry, Pediatrics and Family Medicine, University of Western Ontario, London, ON
Can J Clin Pharmacol 13:e50-62. 2006The thrice daily dosing regimen of immediate release methylphenidate (IR-MPH) for Attention Deficit/Hyperactivity Disorder (ADHD) requires in-school dosing, leading to issues surrounding dispensing and storage of controlled substances by ..
- Efficacy of a novel biphasic controlled-release methylphenidate formula in adults with attention-deficit/hyperactivity disorder: results of a double-blind, placebo-controlled crossover studyUmesh Jain
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
J Clin Psychiatry 68:268-77. 2007To evaluate the efficacy and safety of a new biphasic multilayer-release (MLR) methylphenidate formulation in a double-blind, placebo-controlled crossover study of adults with attention-deficit/hyperactivity disorder (ADHD).
- Pharmacokinetics of methylphenidate after oral administration of two modified-release formulations in healthy adultsJohn S Markowitz
Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425 0742, USA
Clin Pharmacokinet 42:393-401. 2003To compare the rate and extent of absorption of DL-threo-methylphenidate (MPH) from two modified-release MPH formulations at their respective recommended starting doses in healthy adult volunteers.
- Striatal creatine and glutamate/glutamine in attention-deficit/hyperactivity disorderNormand J Carrey
Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
J Child Adolesc Psychopharmacol 17:11-7. 2007..We used short echo proton magnetic resonance spectroscopy (1H-MRS) to examine glutamate in the prefrontal cortex, left striatum, and, as a control area, the occipital lobe...
- Effects of methylphenidate, desipramine, and L-dopa on attention and inhibition in children with Attention Deficit Hyperactivity DisorderC C E Overtoom
Department of Psychopharmacology, Faculty of Pharmacy, Utrecht University, P O BOX 80082, 3508 TB, Utrecht, The Netherlands
Behav Brain Res 145:7-15. 2003The objective of this study was to investigate the effects of methylphenidate (MPH) on attention and inhibition in children with Attention Deficit Hyperactivity Disorder (ADHD) and to establish what the relative contributions of the ..
- Persistence of pharmacological treatment into adulthood, in UK primary care, for ADHD patients who started treatment in childhood or adolescenceSuzanne McCarthy
School of Pharmacy, University College Cork, Cork, Ireland
BMC Psychiatry 12:219. 2012....
- The use of methylphenidate among students: the future of enhancement?Simon M Outram
Novel Tech Ethics, Dalhousie University, 1234 LeMarchant Street, Halifax NS B3H 3P7, Canada
J Med Ethics 36:198-202. 2010..following paper seeks to examine the foundations of this cognitive enhancement debate using the example of methylphenidate use among college students...
- Selective effects of methylphenidate in attention deficit hyperactivity disorder: a functional magnetic resonance studyC J Vaidya
Department of Psychology, Stanford University, Stanford, CA 94305
Proc Natl Acad Sci U S A 95:14494-9. 1998..Hyperactivity Disorder (ADHD) and healthy controls in their frontal-striatal function and its modulation by methylphenidate during response inhibition. Children performed two go/no-go tasks with and without drug...
- Core ADHD symptom improvement with atomoxetine versus methylphenidate: a direct comparison meta-analysisPhilip L Hazell
Discipline of Psychological Medicine, Concord Clinical School, The University of Sydney, Australia
J Atten Disord 15:674-83. 2011Previous studies comparing atomoxetine and methylphenidate to treat ADHD symptoms have been equivocal...
- Modulation of social influence by methylphenidateDaniel K Campbell-Meiklejohn
Center for Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark
Neuropsychopharmacology 37:1517-25. 2012..b>Methylphenidate (MPH) is an indirect dopamine and noradrenalin agonist, commonly used for the treatment of attention-deficit ..
- An observational study of once-daily modified-release methylphenidate in ADHD: effectiveness on symptoms and impairment, and safetyManfred Dopfner
Department of Child and Adolescent Psychiatry, University of Cologne, Cologne, Germany
Eur Child Adolesc Psychiatry 20:S243-55. 2011ADHD affects over 5% of children worldwide. It is typically treated with stimulant medications, and methylphenidate (MPH) is the most commonly prescribed...
- Safety of therapeutic methylphenidate in adults: a systematic review of the evidenceJ Godfrey
Westhaven and Portland CMHT, Westhaven, Weymouth, Dorset, UK
J Psychopharmacol 23:194-205. 2009Attention deficit hyperactivity disorder (ADHD) often persists into adulthood. Stimulant drugs, including methylphenidate, have showed efficacy in trials for ADHD in adults...
- Comparative efficacy and acceptability of methylphenidate and atomoxetine in treatment of attention deficit hyperactivity disorder in children and adolescents: a meta-analysisRaveen Hanwella
Department of Psychological Medicine, Faculty of Medicine, University of Colombo, Sri Lanka
BMC Psychiatry 11:176. 2011Psychostimulants and non stimulants are effective in the treatment of ADHD. Efficacy of both methylphenidate and atomoxetine has been established in placebo controlled trials...
- Assessing the abuse potential of methylphenidate in nonhuman and human subjects: a reviewS H Kollins
Department of Psychiatry, Duke University Medical Center, Box 3431, Durham, NC 27710, USA
Pharmacol Biochem Behav 68:611-27. 2001b>Methylphenidate (MPH) is widely used for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in children, adolescents, and adults...
- Methylphenidate treatment in adolescent rats with an attention deficit/hyperactivity disorder phenotype: cocaine addiction vulnerability and dopamine transporter functionRoxann C Harvey
Department of Psychology, Boston University, Boston, MA 02215, USA
Neuropsychopharmacology 36:837-47. 2011..Initially, 1.5 mg/kg oral methylphenidate or vehicle was administered between postnatal days 28 and 55, and acquisition of visual discrimination ..
- Age-specific prevalence, incidence of new diagnoses, and drug treatment of attention-deficit/hyperactivity disorder in GermanyChristina Lindemann
Bremen Institute for Prevention Research and Social Medicine, Bremen, Germany
J Child Adolesc Psychopharmacol 22:307-14. 2012..The purpose of this study was to estimate the prevalence and incidence of new diagnoses of attention-deficit/hyperactivity disorder (ADHD) and assess drug treatment of ADHD in the 3-17 year age group in Germany...
- Dopamine transporter gene (DAT1) associated with appetite suppression to methylphenidate in a case-control study of binge eating disorderCaroline Davis
Department of Kinesiology and Health Sciences, York University, Toronto, ON, Canada
Neuropsychopharmacology 32:2199-206. 2007..The current study used a double blind, crossover (methylphenidate vs placebo) design to assess DAT1 genotype differences on appetite ratings to a snack-food cue in subjects ..
- Non-specific effects of methylphenidate (Ritalin) on cognitive ability and decision-making of ADHD and healthy adultsNirit Agay
Israel Institute of Technology, Haifa, 32000, Israel
Psychopharmacology (Berl) 210:511-9. 2010The effect of a single dose of methylphenidate (MPH) on cognitive measures and decision-making processes was assessed in a sample of adults with ADHD and in a control sample.
- ADHD in children, adolescents, and adultsSreenivas Katragadda
Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH 03766, USA
Prim Care 34:317-41; abstract viii. 2007..The primary care physician should be able to screen, diagnose, educate, and initiate medication management in patients with uncomplicated ADHD...
- Functional improvement and correlations with symptomatic improvement in adults with attention deficit hyperactivity disorder receiving long-acting methylphenidateJ K Buitelaar
Department of Cognitive Neuroscience, University Medical Centre, St Radboud and Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, The Netherlands
Psychol Med 42:195-204. 2012..Daily functioning was assessed as part of an open-label extension, and associations with symptom scores were evaluated...
- Methylphenidate and risk of serious cardiovascular events in adultsHedi Schelleman
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
Am J Psychiatry 169:178-85. 2012The authors sought to determine whether use of methylphenidate in adults is associated with elevated rates of serious cardiovascular events compared with rates in nonusers.
- Sex differences in attentional performance and their modulation by methylphenidate in children with attention-deficit/hyperactivity disorderThomas Gunther
Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, University Hospital of the RWTH Aachen, Aachen, Germany
J Child Adolesc Psychopharmacol 20:179-86. 2010..known about neuropsychological differences between boys and girls with attention-deficit/hyperactivity disorder (ADHD) and whether there are sex-specific differences in the modulation of attentional performance by methylphenidate (MPH).
- Effects of acute and chronic administration of atomoxetine and methylphenidate on extracellular levels of noradrenaline, dopamine and serotonin in the prefrontal cortex and striatum of miceKen Koda
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565 0871, Japan
J Neurochem 114:259-70. 2010Acute administration of atomoxetine and methylphenidate, attention-deficit/hyperactivity disorder (ADHD) drugs, activates catecholaminergic systems in rat brain, but the effects of their chronic administration are not known...
- Methylphenidate HCl: therapy for attention deficit hyperactivity disorderPhilip K Capp
George Washington University, Department of Neurology, Children s National Medical Center, School of Medicine, Washington DC, USA
Expert Rev Neurother 5:325-31. 2005b>Methylphenidate is a first-line therapy for attention deficit hyperactivity disorder, the most prevalent neuropsychiatric disorder of childhood...
- Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptorsN D Volkow
Brookhaven National Laboratory, Upton, New York, USA
J Pharmacol Exp Ther 291:409-15. 1999..v. methylphenidate in 14 healthy controls...
- A double-blind, placebo-controlled study of Adderall and methylphenidate in the treatment of attention-deficit/hyperactivity disorderS R Pliszka
Division of Child and Adolescent Psychiatry, University of Texas Health Science Center, San Antonio UTHSCSA 78284 7792, USA
J Am Acad Child Adolesc Psychiatry 39:619-26. 2000While Adderall has been available for the treatment of attention-deficit/hyperactivity disorder (ADHD) for several years, there are few controlled studies comparing it to methylphenidate.
- Methylphenidate-induced improvements of various measures of attention in adults with attention deficit hyperactivity disorderO Tucha
Department of Experimental Psychology, University of Regensburg, Regensburg, Germany
J Neural Transm 113:1575-92. 2006The present study examined the effect of the stimulant medication methylphenidate (MPH) on attentional functioning of adults with ADHD...
- Methylphenidate improves deficient error evaluation in children with ADHD: an event-related brain potential studyLisa M Jonkman
Faculty of Psychology, Department of Cognitive Neuroscience, Maastricht University, Maastricht, The Netherlands
Biol Psychol 76:217-29. 2007..Furthermore, effects of methylphenidate were investigated in ADHD children in a second study...
- Differential effects of psychomotor stimulants on attentional performance in rats: nicotine, amphetamine, caffeine and methylphenidateL Bizarro
Section of Behavioural Pharmacology, Institute of Psychiatry P049, King s College London, UK
Behav Pharmacol 15:195-206. 2004..This study compared the effects of nicotine, amphetamine, caffeine and methylphenidate on performance in the 5-CSRTT and determined whether presenting stimuli at unpredictable times by using ..
- Effects of clonidine and methylphenidate on family quality of life in attention-deficit/hyperactivity disorderMichael Cannon
Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
J Child Adolesc Psychopharmacol 19:511-7. 2009The aim of this study was to determine the effect on family quality of life (QOL) of clonidine (CLON) and methylphenidate (MPH), used alone and in combination, in treating attention-deficit/hyperactivity disorder (ADHD).
- A double-blind, placebo-controlled study of modified-release methylphenidate in children with attention-deficit/hyperactivity disorderLaurence L Greenhill
New York State Psychiatric Institute, New York, New York 10032, USA
Pediatrics 109:E39. 2002To compare the efficacy, safety, and tolerability of once-daily administration of modified-release methylphenidate (MPH MR) with placebo in children with attention-deficit/hyperactivity disorder (ADHD).
- Juvenile administration of methylphenidate attenuates adult hippocampal neurogenesisDiane C Lagace
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Biol Psychiatry 60:1121-30. 2006The neural consequences of early-life exposure to methylphenidate (MPH; Ritalin) are of great interest given the widespread, and sometimes inappropriate, use in children...
- Understanding the effects of stimulant medications on cognition in individuals with attention-deficit hyperactivity disorder: a decade of progressJames Swanson
Department of Pediatrics, University of California, Irvine, CA, USA
Neuropsychopharmacology 36:207-26. 2011..This treatment is well grounded on controlled studies showing efficacy of low oral doses of methylphenidate and amphetamine in reducing the behavioral symptoms of the disorder as reported by parents and teachers, both ..
- The neuropharmacology of ADHD drugs in vivo: insights on efficacy and safetyD J Heal
RenaSci Consultancy Ltd, BioCity, Nottingham NG1 1GF, UK
Neuropharmacology 57:608-18. 2009..classes: psychostimulant releasing agents, eg d-amphetamine; psychostimulant reuptake inhibitors, eg dl-threo-methylphenidate (dl-MPH), and non-stimulant reuptake inhibitors, eg atomoxetine...
- Pattern classification of working memory networks reveals differential effects of methylphenidate, atomoxetine, and placebo in healthy volunteersAndre F Marquand
Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, London, UK
Neuropsychopharmacology 36:1237-47. 2011..The stimulant drug methylphenidate (MPH) and the non-stimulant drug atomoxetine (ATX) are both widely used for ADHD treatment, but their ..
- Neurochemical enhancement of conscious error awarenessRobert Hester
Department of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia
J Neurosci 32:2619-27. 2012..We conducted a randomized, double-blind, placebo-controlled, cross-over design of the influence of methylphenidate, atomoxetine, and citalopram on error awareness in 27 healthy participants...
- Phenotypic characterization of a new Grin1 mutant mouse generated by ENU mutagenesisTamio Furuse
Technology and Development Team for Mouse Phenotype Analysis Japan Mouse Clinic, RIKEN BioResource Center, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
Eur J Neurosci 31:1281-91. 2010..The results of immunohistochemical and biochemical analyses suggested that impaired interaction between the glutamatergic pathway and dopaminergic pathway may underlie the behavioral phenotypes of the Grin1(Rgsc174) mutant...
- What are the cognitive effects of stimulant medications? Emphasis on adults with attention-deficit/hyperactivity disorder (ADHD)Claire Advokat
Department of Psychology, Louisiana State University, 215 Audubon Hall, Baton Rouge, LA 70803, USA
Neurosci Biobehav Rev 34:1256-66. 2010The relevant literature concerning cognitive effects of amphetamine and methylphenidate, was reviewed, with an emphasis on research conducted in adults diagnosed with attention-deficit/hyperactivity disorder...
- Effects of atomoxetine and methylphenidate on attention and impulsivity in the 5-choice serial reaction time testRachel Navarra
Discovery Neuroscience, Wyeth Research, 500 Arcola Road, PA 19426 USA
Prog Neuropsychopharmacol Biol Psychiatry 32:34-41. 2008..first non-stimulant based drug approved for Attention Deficit Hyperactivity Disorder (ADHD) and has replaced methylphenidate (Ritalin) as the first line in pharmacotherapy for the treatment of ADHD...
- Effects of methylphenidate on the catecholaminergic system in attention-deficit/hyperactivity disorderTimothy E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Clin Psychopharmacol 28:S46-53. 2008Stimulants are part of the standard-of-care treatment for attention-deficit/hyperactivity disorder (ADHD). Methylphenidate, with a history of use spanning approximately 5 decades, is a first-line stimulant treatment for ADHD...
- Effect of methylphenidate on executive functioning in adults with attention-deficit/hyperactivity disorder: normalization of behavior but not related brain activityJulie B Schweitzer
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA
Biol Psychiatry 56:597-606. 2004We examined the effect of prolonged methylphenidate (MPH) treatment on the functional neuroanatomy of executive functioning in adult men with attention-deficit/hyperactivity disorder (ADHD).
- Impulsiveness as a timing disturbance: neurocognitive abnormalities in attention-deficit hyperactivity disorder during temporal processes and normalization with methylphenidateKatya Rubia
Department of Child Psychiatry MRC Center for Social, Genetic and Developmental Psychiatry SGDP, Institute of Psychiatry, 16 De Crespigny Park, London, UK
Philos Trans R Soc Lond B Biol Sci 364:1919-31. 2009..dysfunctions in ADHD children during time discrimination with the dopamine agonist and treatment of choice, methylphenidate. This review together with the new empirical findings demonstrates that neurocognitive dysfunctions in ..
- A 90-day oral gavage toxicity study of D-methylphenidate and D,L-methylphenidate in Sprague-Dawley ratsSteve Teo
Pharmacokinetics and Toxicology, Celgene Corporation, 7 Powder Horn Drive, Warren, NJ 07059, USA
Toxicology 179:183-96. 2002D-methylphenidate is an enantiomer of D,L-methylphenidate and was developed as an improved treatment for attention deficit hyperactivity disorder in children...
- Dimensional analysis of ADHD subtypes in ratsCandice Blondeau
Hôpital Charles Perrens, Laboratoire de Neuropsychobiologie des Desadaptations, Université Victor Segalen Bordeaux 2 CNRS UMR 554 1, Bordeaux, France
Biol Psychiatry 61:1340-50. 2007..The nature of the biological dysfunction sustaining each subtype (common or distinct) is unknown, and animal models encompassing different subtypes are needed...
- Functional magnetic resonance imaging of methylphenidate and placebo in attention-deficit/hyperactivity disorder during the multi-source interference taskGeorge Bush
Departments of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Arch Gen Psychiatry 65:102-14. 2008..Stimulant medications are effective treatments for ADHD, but their neural effects have not been fully characterized...
- ADHD- and medication-related brain activation effects in concordantly affected parent-child dyads with ADHDJeffery N Epstein
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Child Psychol Psychiatry 48:899-913. 2007..Our objective was to examine functional brain abnormalities among youths and adults with ADHD and to examine the relations between these neurobiological abnormalities and response to stimulant medication...
- Clinically relevant doses of methylphenidate significantly occupy norepinephrine transporters in humans in vivoJonas Hannestad
Department of Psychiatry, Yale PET Center, Yale University School of Medicine, New Haven, Connecticut, USA
Biol Psychiatry 68:854-60. 2010..The mechanism of action of methylphenidate, the most common treatment for attention deficit hyperactivity disorder, is unclear...
- Cardiovascular effects of methylphenidate, amphetamines and atomoxetine in the treatment of attention-deficit hyperactivity disorderGary Stiefel
St Mary s Hospital, London, UK
Drug Saf 33:821-42. 2010..Drugs such as methylphenidate, amphetamines and atomoxetine are frequently prescribed as part of management...
- Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: implications for the monoaminergic basis of impulsive behaviourR D Rogers
Departments of Experimental Psychology and Psychiatry, University of Cambridge, Cambridge, UK
Psychopharmacology (Berl) 146:482-91. 1999..However, little research has addressed the specific cognitive consequences of changed monoaminergic function that might contribute to the production of impulsive behaviour...
- Progress and promise of attention-deficit hyperactivity disorder pharmacogeneticsTanya E Froehlich
Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
CNS Drugs 24:99-117. 2010..ADHD pharmacogenetic investigative efforts to date, which have primarily focused on short-term response to methylphenidate and largely been limited by modest sample sizes...
- A randomised, placebo-controlled, 24-week, study of low-dose extended-release methylphenidate in adults with attention-deficit/hyperactivity disorderMichael Rösler
Neurocenter, Saarland University Hospital, 66421, Homburg Saar, Germany
Eur Arch Psychiatry Clin Neurosci 259:120-9. 2009..Although stimulants and methylphenidate in particular are a common off-label treatment for adult patients with ADHD in European countries, little is ..
- New perspectives from microdialysis studies in freely-moving, spontaneously hypertensive rats on the pharmacology of drugs for the treatment of ADHDD J Heal
RenaSci Consultancy Limited, BioCity, Nottingham NG1 1GF, UK
Pharmacol Biochem Behav 90:184-97. 2008..Furthermore, experiments performed with the enantiomers of amphetamine and threo-methylphenidate demonstrate that pharmacodynamic effects of drugs reported from experiments in outbred rat strains, e.g...
- Recovery in pediatric brain injury: is psychostimulant medication beneficial?S E Williams
Department of Psychiatry, Stanford University Medical Center, Stanford, California 94305, USA
J Head Trauma Rehabil 13:73-81. 1998To assess the effects of methylphenidate on attention, memory, behavior, processing speed, and psychomotor skills of children with closed head injuries.
- [(11)C]d-threo-methylphenidate PET in patients with Parkinson's disease and essential tremorS Breit
Department of Neurology, University of Tubingen, Tubingen, Germany
J Neural Transm 113:187-93. 2006..essential tremor and 10 healthy controls were studied with the dopamine transporter ligand [(11)C]d-threo-methylphenidate ([(11)C]dMP) and positron emission tomography (PET) to assess dopamine terminal loss in relation to disease ..
- A post hoc comparison of the effects of lisdexamfetamine dimesylate and osmotic-release oral system methylphenidate on symptoms of attention-deficit hyperactivity disorder in children and adolescentsCesar Soutullo
Child and Adolescent Psychiatry Unit, Department of Psychiatry and Medical Psychology, University of Navarra Clinic, Pio XII, S N, 31008 Pamplona, Spain
CNS Drugs 27:743-51. 2013There are limited head-to-head data comparing the efficacy of long-acting amfetamine- and methylphenidate-based psychostimulants as treatments for individuals with attention-deficit hyperactivity disorder (ADHD)...
- Single- and multiple-dose pharmacokinetics of methylphenidate administered as methylphenidate transdermal system or osmotic-release oral system methylphenidate to children and adolescents with attention deficit hyperactivity disorderDavid Pierce
Shire Pharmaceutical Development Ltd, Hampshire International Business Park, Chineham, Basingstoke, Hampshire, UK
J Clin Psychopharmacol 30:554-64. 2010..multicenter, open-label, randomized study to determine single- and multiple-dose pharmacokinetics of d,l-methylphenidate (MPH) after MPH transdermal system (MTS) and osmotic-release oral system MPH (OROS MPH) dosing in children (6-..
- Treatment discontinuation with methylphenidate in adults with attention deficit hyperactivity disorder: a meta-analysis of randomized clinical trialsXavier Castells
Department of Medical Sciences, TransLab Research Group, Universitat de Girona, Girona, Spain
Eur J Clin Pharmacol 69:347-56. 2013Attention deficit hyperactivity disorder (ADHD) in adulthood is increasingly diagnosed and treated. Methylphenidate is frequently advocated as a first-line pharmacological treatment.
- Abuse and dependence liability analysis of methylphenidate in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder (ADHD): what have we learned?Ike dela Peña
Department of Pharmacy, Sahmyook University, 26 21 Kongreung 2 dong, Hwarangro 815, Nowon Gu, Seoul, 139 742, Korea
Arch Pharm Res 36:400-10. 2013b>Methylphenidate is the most prescribed stimulant medication for attention-deficit/hyperactivity disorder (ADHD)...
- Conditioned place preference induced by social play behavior: parametrics, extinction, reinstatement and disruption by methylphenidateViviana Trezza
Rudolf Magnus Institute of Neuroscience, Dept of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
Eur Neuropsychopharmacol 19:659-69. 2009..Treatment with methylphenidate, which disrupts social play behavior in adolescent rats, but not social exploratory behavior, prevented the ..
- A phase III, double-blind, placebo-controlled prospective randomized clinical trial of d-threo-methylphenidate HCl in brain tumor patients receiving radiation therapyJerome M Butler
Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Int J Radiat Oncol Biol Phys 69:1496-501. 2007..We assessed the effect of prophylactic d-threo-methylphenidate HCl (d-MPH), a central nervous system (CNS) stimulant on QOL and cognitive function in patients undergoing RT.
- Efficacy and safety of OROS methylphenidate in adults with attention-deficit/hyperactivity disorder: a randomized, placebo-controlled, double-blind, parallel group, dose-escalation studyLenard A Adler
NYU School of Medicine, New York VA Harbor Healthcare System, New York, NY 10016, USA
J Clin Psychopharmacol 29:239-47. 2009To assess the efficacy and safety of OROS methylphenidate (Concerta; McNeil Pediatrics Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc, Titusville, NJ) in the management of attention-deficit/hyperactivity disorder (ADHD) in adults.
- Neurofunctional effects of methylphenidate and atomoxetine in boys with attention-deficit/hyperactivity disorder during time discriminationAnna Smith
Department of Child Psychiatry, Institute of Psychiatry, King s College London, United Kingdom Electronic address
Biol Psychiatry 74:615-22. 2013The catecholamine agonists methylphenidate and atomoxetine effectively treat attention-deficit/hyperactivity disorder (ADHD). Furthermore, dopamine agonists have shown to improve time estimation in ADHD, a core cognitive deficit...
- Bioequivalence of methylphenidate immediate-release tablets using a replicated study design to characterize intrasubject variabilityM C Meyer
Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, Memphis 38163, USA
Pharm Res 17:381-4. 2000To determine the relative bioavailability of two marketed, immediate-release methylphenidate tablets...
- Methylphenidate exposure induces dopamine neuron loss and activation of microglia in the basal ganglia of miceShankar Sadasivan
Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
PLoS ONE 7:e33693. 2012b>Methylphenidate (MPH) is a psychostimulant that exerts its pharmacological effects via preferential blockade of the dopamine transporter (DAT) and the norepinephrine transporter (NET), resulting in increased monoamine levels in the ..
- One-year prospective follow-up of pharmacological treatment in children with attention-deficit/hyperactivity disorderAnna Didoni
Department of Public Health and of the Laboratory for Mother and Child Health, Mario Negri Pharmacological Research Institute, Via Giuseppe La Masa 19, 20156 Milan, Italy
Eur J Clin Pharmacol 67:1061-7. 2011To delineate the safety and tolerability profile of methylphenidate and atomoxetine in children and adolescents with attention deficit hyperactivity disorder (ADHD) monitored for more than 1 year.
- Assessment of pharmacokinetics and pharmacodynamic effects related to abuse potential of a unique oral osmotic-controlled extended-release methylphenidate formulation in humansDolly A Parasrampuria
McNeil Pediatrics, Division of McNeil PPC, 420 Delaware Drive, Fort Washington, PA 19034, USA
J Clin Pharmacol 47:1476-88. 2007..stimulant use, to evaluate the abuse-related subjective effects of oral osmotic-controlled extended-release methylphenidate with comparable doses of immediate-release methylphenidate...
- Methylphenidate treatment of adult male prison inmates with attention-deficit hyperactivity disorder: randomised double-blind placebo-controlled trial with open-label extensionYlva Ginsberg
Department of Clinical Neuroscience, Division of Psychiatry and Center of Neurodevelopmental Disorders, Karolinska Institutet, Stockholm, Sweden
Br J Psychiatry 200:68-73. 2012..Attention-deficit hyperactivity disorder (ADHD) is highly prevalent in prison inmates, but pharmacological treatment has not yet been evaluated in this group...
- Expectation to receive methylphenidate enhances subjective arousal but not cognitive performanceAlison Looby
Department of Psychology, University at Albany, State University of New York, USA
Exp Clin Psychopharmacol 19:433-44. 2011Nonmedical use of prescription-stimulant medication such as methylphenidate (MPH) has increased among college students over the past several years. Common motivations for use include enhancements in cognition and subjective arousal...
- Slowing of growth in height and weight on stimulants: a characteristic patternA Poulton
Department of Paediatrics, Nepean Hospital, Penrith, New South Wales, Australia
J Paediatr Child Health 39:180-5. 2003..The aims of the present study were to describe the growth pattern of children starting stimulant medication and to analyse the changes over time in height, weight and height velocity in a cohort of treated patients...
- Validation of a functional MRI-based reward processing task as a non-invasive tooMARY LOUISE PHILLIPS; Fiscal Year: 2010..from animal studies and human neuroimaging studies involving pharmacological challenge with amphetamine and methylphenidate support the role of dopamine (DA) release in reward-related ventral striatal (VS) functioning...
- Dopamine Transporter Structure and FunctionChristopher K Surratt; Fiscal Year: 2010..the DAT, as well as information on DAT recognition of drugs with less abuse potential such as benztropine and methylphenidate. Elucidating at the amino acid residue level the mechanisms of discriminating abused and non-abused ..
- smFRET Investigation of Gating in a Neurotransmitter Transporter HomologRACHEL ANN KOLSTER; Fiscal Year: 2013..includes the transporters for serotonin, dopamine, and norepinephrine, which are targeted by antidepressants, methylphenidate (Ritalin), and the widely abused psychostimulants cocaine and amphetamine...
- PCBs, PBDEs, Hearing Loss & Attention/Impulsivity: Mechanistic Studies in AnimalsSusan L Schantz; Fiscal Year: 2010..Drug challenges with methylphenidate and amphetamine will determine if commonly prescribed ADHD pharmacotherapies improve the performance of PCB- ..
- Dopamine Transporter Cell Surface DynamicsHaley E Melikian; Fiscal Year: 2013..and is the primary target for addictive and therapeutic psychostimulants, such as amphetamine, cocaine and methylphenidate (Ritalin) as well as for antidepressants, such as bupropion (Wellbutrin)...
- Neuroimaging and Behavioral Biomarkers for ADHD in ChildrenMartin H Teicher; Fiscal Year: 2010..only included boys aged 9 - 12 who met criteria for Combined Subtype, and had been previously treated with methylphenidate (MPH)...
- Dopamine Transporter Regulation by EndocytosisAlexander D Sorkin; Fiscal Year: 2013..neurons and to determine how these dynamics are regulated by psychostimulant drugs of abuse such as cocaine, methylphenidate (MPH) and amphetamine (AMPH)...
- The rodent continuous performance task: Filling the vigilance translational gapJARED WILLIAM YOUNG; Fiscal Year: 2010..predictive validity of the rCPT by determining whether psychostimulants such as nicotine, amphetamine, and methylphenidate will improve performance and whether ketamine will impair vigilance performance, consistent with human CPT ..
- Modeling Developmental Neurotoxicity of Pesticides in ZebrafishLori A White; Fiscal Year: 2010..DAT) levels, hyperactivity and impulsive-like behavior, amelioration of the behavioral deficits by methylphenidate (Ritalin), and a male gender-preference of these effects...
- Locus Coeruleus Function and Methylphenidate ActionBARRY DALE WATERHOUSE; Fiscal Year: 2013..project is to investigate interactions between the central noradrenergic system and systemically administered methylphenidate (MPH) - RitalinR in juvenile, adult and aged rats...
- The Role of Apathy in Glycemic ControlCyrus V Desouza; Fiscal Year: 2011..Specific Aim 1: Evaluate if methylphenidate treatment of apathy improves glycemic control in patients with poorly controlled diabetes...
- Genetic Variants of Human Carboxylesterase 1 Influence the Activation and AntivirJohn S Markowitz; Fiscal Year: 2012..Markedly altered pharmacokinetic and pharmacodynamic profiles of the hCES1 selective substrate methylphenidate have been observed in a human subject carrying the hCES1 variants, Gly143Glu and Asp260fs, during our ..
- DBH, D2High and Cocaine Paranoia/Aversion: A [11C]PHNO PET StudyRobert T Malison; Fiscal Year: 2010..D2 receptor (D2high), and 3) individual sensitivity to the subjectively aversive effects of psychostimulants (methylphenidate and/or cocaine)...
- Phosphorylation and Regulation of Dopamine TransportersRoxanne A Vaughan; Fiscal Year: 2010....
- Endotoxin-induced inflammation affects striatal dopamine: A raclopride PET studyEvan D Morris; Fiscal Year: 2013..double-blind study, we will use positron emission tomography (PET) and [C-11]raclopride to measure methylphenidate-induced release of dopamine in the striatum in 10 healthy subjects...
- Non-Tropane Irreversible Dopamine Transporter LigandsDAVID JOHN LAPINSKY; Fiscal Year: 2010..based irreversible ligands essential for labeling the DAT;and 2) Identify the structural elements of methylphenidate-based irreversible ligands for labeling the DAT...
- Neurobehavioral Impacts of Early Mn ExposuresDonald R Smith; Fiscal Year: 2013..resulting behavioral deficits by determining whether Mn exposure alters the dose- response relationship of methylphenidate (Ritalin), a dopamine transporter (DAT) inhibitor, and whether the drug alleviates behavioral deficits due to ..
- Preweanling Methylphenidate Exposure and Reward BehaviorCynthia Crawford; Fiscal Year: 2009..for attention deficit hyperactivity disorder (ADHD) and the majority of these children are treated with methylphenidate (Ritalin)...
- Apathy in Alzheimer's Disease Methylphenidate TrialPaul B Rosenberg; Fiscal Year: 2010..from a double blind, placebo controlled single-site crossover pilot study suggest that the dopamine agonist methylphenidate was superior to placebo for the treatment of apathy in AD (Lancttt, in press)...
- Characterization and Sequential Pharmacotherapy of Severe Mood DysregulationJAMES JOHN MCGOUGH; Fiscal Year: 2013..First, all participants will have a 4-week open-label stimulant trial with dextro- methylphenidate extended release (d-MPH-XR) to determine an optimal dose...
- Comparative Safety and Effectiveness of Stimulants in Medicaid Youth with ADHDAlmut G Winterstein; Fiscal Year: 2010..2006 to: (1) evaluate the cardiac risk of stimulants overall, and of mixed amphetamine salts (MAS) versus methylphenidate (MPH) individually, on fatal or severe cardiovascular events;(2) assess whether stimulant risk is modified ..
- Developmental Mechanisms Underlying Risk Behaviors and Their TreatmentKai Christian Sonntag; Fiscal Year: 2013..In Aim 2, we will determine effective doses (ED50s) of methylphenidate, atomoxetine, and guanficine on impulsivity at different ages and across sex...
- Structural and Mechanistic Characterization of Neurotransmitter Reuptake InhibitiDANENG WANG; Fiscal Year: 2012..and therefore are the primary targets for: antidepressants such as fluoxetine (Prozac), sertraline (Zoloft), methylphenidate (Ritalin) -a prescription drug commonly used to treat attention-deficit hyperactivity disorder (ADHD), and ..
- Improving Psychiatric Interventions at the End of LifeScott A Irwin; Fiscal Year: 2012..Small studies and our pilot work have provided initial evidence for the safety and efficacy of methylphenidate for rapidly treating depression in hospice settings...
- Low-Dose Methylphenidate and the Prefrontal CortexCraig W Berridge; Fiscal Year: 2013Low doses of psychostimulants, including methylphenidate (MPH/Ritalin), are widely used clinically due to their behavioral-calming and cognition-enhancing actions...
- How and Where Methylphenidate Exerts Effect in Adolescent and Adult BrainsNachum Dafny; Fiscal Year: 2013..of the Journal of the American Academy of child and adolescent Psychiatry report the risks and benefits of methylphenidate (MPD) use in the treatment of attention deficit hyperactive disorder (ADHD) and strongly indicate the need of ..
- Bulimia nervosa and dopamine: a link to addictions?Allegra I Broft; Fiscal Year: 2012..Patients and controls will undergo 2 PET scans with [11C]raclopride, pre/post pharmacological challenge with methylphenidate, for the measurement of striatal DA type 2 (D2) receptor binding potential (BP) and DA release...
- Methylphenidate, opioid receptors and addictionJinmin Zhu; Fiscal Year: 2011..provided by applicant): The long term goals of this project are to determine if oral therapeutic doses of methylphenidate are associated with increased risk of drug addiction...
- Drugs of Abuse and Memory SpanJOSEPH MARK GALIZIO; Fiscal Year: 2012..midazolam), NMDA antagonists (dizocilpine, ketamine), opiates (morphine), psychostimulants (methylphenidate, methamphetamine, MDMA), and an anticholinergic hallucinogen (scopolamine)...
- Alcohol Biomarkers In Post Liver Transplant PatientsMichael F Fleming; Fiscal Year: 2013..The second study tested the efficacy of methylphenidate in a sample 13 children with a diagnosis of Attention Deficit Disorder and Fetal Alcohol Spectrum Disorder...
- Translational and epigenetic profiling of cell types associated with addictionNathaniel Heintz; Fiscal Year: 2010..addiction;2) to collect translational profiles from each of these cell types in mice exposed to cocaine, methylphenidate, and methamphetamine 3) perform in depth comparative analysis of these resulting microarray datasets to ..
- Methylphenidate, Serotonin and Dopamine InteractionsSara R Jones; Fiscal Year: 2013DESCRIPTION (provided by applicant): The clinical use of methylphenidate (MPH, Ritalin) for treatment of attention-deficit/hyperactivity disorder is widespread, and there is a growing problem of MPH abuse, especially in college-age ..
- Methylphenidate Use to Improve Outcomes in Geriatric DepressionHelen Lavretsky; Fiscal Year: 2012..We hypothesized that the addition of methylphenidate (MPH) to the serotonergic drug, citalopram, may result in better clinical outcomes of the affective and ..
- Novel Ondansetron Formulation for Combination Treatment of Psychostimulant AbuseAshwin A Patkar; Fiscal Year: 2010..pharmacokinetic, safety and pharmacodynamic interactions with simultaneously-administered immediate-release methylphenidate;(3) a proof-of-concept phase II efficacy trial on a combination of immediate-release methylphenidate and Ond-..
- Neurobiology of the Cognition Enhancing Actions of PsychostimulantsRobert C Spencer; Fiscal Year: 2013DESCRIPTION (provided by applicant): Psychostimulants, including methylphenidate (MPH), are currently the most effective treatment for attention-deficit hyperactivity disorder (ADHD)...
- Stimulants and Vascular Events in ADHDMark Olfson; Fiscal Year: 2010..for youth with attention-deficit/hyperactivity disorder (ADHD), mixed salts of amphetamine (MAS) and methylphenidate (MPH), may increase the risk of stroke, myocardial infarction, and other vascular events...
- Traumatic Brain Injury Clinical Trials NetworkJoseph H Ricker; Fiscal Year: 2010..Special emphasis has been placed on the study of the effects of methylphenidate on executive functioning and outcome after TBI and the influence of gender and dopamine transporter genotype ..
- Fine Mapping Genes for Cocaine Locomotor Response in ENU Mutagenized MiceLisa M Tarantino; Fiscal Year: 2010..hyperlocomotion in a novel environment, an exaggerated locomotor response to the psychostimulants cocaine and methylphenidate and a prolonged release of corticosterone following an acute stressor...
- Neuroimaging of diet and medication in the treatment of ADHDSteven R Pliszka; Fiscal Year: 2013..Phase II, (3 years), we will seek to determine the relative and combined efficacy of a restriction diet and methylphenidate in the treatment of ADHD, the acceptability/compliance of the diet to families and the child's ..
- Developmental Neuroendocrine Effects of PCBs and PBDEs: Parallels with ADHDRICHARD FIELD SEEGAL; Fiscal Year: 2010..reductions in central catecholamines can be ameliorated following either maternal T4 supplementation or adult methylphenidate exposure and (iv) the effects of these manipulations on mRNA expression and proteins that regulate ..
- Drug Transporters and the Disposition of ADHD Therapeutic AgentsJohn S Markowitz; Fiscal Year: 2010..Medications include the psychostimulants (STIMs), methylphenidate (MPH) and amphetamine (AMP), and newer non-STIMs atomoxetine (ATM) and modafinil (MDF)...
- Neuropharmacology of Response Inhibition in Comorbid ADHD and Nicotine DependenceFRANCIS JOSEPH MCCLERNON; Fiscal Year: 2013..the following conditions: 1) smoking as usual, 2) 24 hr smoking abstinence, and 3) 24 hr smoking abstinence + methylphenidate (MPH)...
- ADHD Therapeutic: PD2005 DA Transport InhibitorFrank Zemlan; Fiscal Year: 2012..The American Academy of Pediatrics identifies the non-selective DA transport inhibitors methylphenidate and amphetamine as the only approved first-line treatments for ADHD...
- Neural Circuits Underlying Adaptive Behavior and AddictionGERO MIESENBOECK; Fiscal Year: 2013..The effect of cocaine, methylphenidate, and amphetamine on this learning process will be determined, revealing the effects of these drugs of abuse ..
- Methylphenidate, vigilance, and visual perceptionKara L Agster; Fiscal Year: 2010..Amphetamine-like stimulants, such as methylphenidate (MPH, Ritalin), are the primary treatments for ADHD...
- Pharmacological Dissociation of Control Circuits in ADHD and Alcohol DependenceChandra Sekhar Sripada; Fiscal Year: 2013..controls and adults with ADHD, alcohol dependence, and ADHD comorbid with alcohol dependence in response to methylphenidate, naltrexone, and placebo challenge...
- Psychostimulants induce long-term changes in nociception.Michael M Morgan; Fiscal Year: 2013DESCRIPTION (provided by applicant): Psychostimulants, such as methylphenidate (MPH) and methamphetamine, are widely used and abused. The short-term adverse health effects of methamphetamine abuse are well known...
- Career Development AwardANNETTE FLECKENSTEIN; Fiscal Year: 2013..formation is associated with, and may contribute to, the dopaminergic deficits caused by the stimulant;2) methylphenidate uniquely affects monoaminergic vesicular function and distribution by a mechanism that includes novel shifts ..
- PET Studies of Amphetamine Treatment of ADHDGeorge A Ricaurte; Fiscal Year: 2013..who have never received pharmacological treatment for ADHD;2) Adults with ADHD who have been treated with methylphenidate, which is known to lack DA neurotoxic potential;and 3) Age- and gender- matched healthy adults never treated ..
- Risk of cocaine addiction after methylphenidate plus SSRI combination treatmentMichela Marinelli; Fiscal Year: 2013DESCRIPTION (provided by applicant): Exposure to methylphenidate (a dopamine reuptake inhibitor) mimics several behavioral and molecular effects of cocaine...
- Sustained-Release Methylphenidate For Management of Methamphetamine Use DisordersWALTER NMN LING; Fiscal Year: 2012DESCRIPTION (provided by applicant): This four-year study will evaluate the efficacy of treatment with methylphenidate compared to placebo in the context of behavioral therapy for methamphetamine use disorders (abuse or dependence) in a ..
- Efficacy of an Expectancy Challenge to Reduce Non-Prescribed Use of Stimulant MedALLISON LABBE; Fiscal Year: 2012..provided by applicant): Non-prescribed use of stimulant medications among college students, such as methylphenidate (Ritalin(R)) and amphetamine (Adderall(R)), has become a public health concern...
- Patterns of Drug Use and Abuse in the Brazilian Rave CultureJames Inciardi; Fiscal Year: 2009..ecstasy), GHB, ketamine, LSD, methamphetamine, and a few prescription drugs, such as dextroamphetamine and methylphenidate. Recently, reports in both popular and scientific media have begun to indicate that ecstasy use is increasing ..
- Impulsivity and Stimulant Response in Early- and Late-Onset CD with Comorbid ADHDCharles W Mathias; Fiscal Year: 2013DESCRIPTION (provided by applicant): The purpose of this study is to determine the dose-response effects of methylphenidate treatment on laboratory-measured impulsive behavior of two groups of adolescents, those with either childhood- ..
- Extended-Release Mixed Amphetamine Salts for Adults ADHD and Cocaine DependenceJOHN G GRABOWSKI; Fiscal Year: 2012..To date studies of immediate and sustained-release methylphenidate for adult cocaine-dependent individuals with ADHD have produced mixed results, suggesting that high doses of ..
- Functional Neuroimaging of Attention in AutismBENJAMIN YERYS; Fiscal Year: 2012..from Attention Deficit/Hyperactivity Disorder (ADHD), but this approach has shown reduced efficacy of methylphenidate (i.e., ritalin) treatment in children with ASD...
- Smoking/Nicotine Dependence in Attention Deficit Hyperactivity Disorder (ADHD)Scott H Kollins; Fiscal Year: 2012..These studies include: 1) an existing human laboratory study of the abuse liability of methylphenidate in adults with and without ADHD (R01DA017196);2) an existing candidate gene study of persistent ADHD (..
- The prefrontal cortex in salience and control in cocaine addiction: phFMRI studyRita Z Goldstein; Fiscal Year: 2012..We will compare these fMRI results with and without oral methylphenidate (MPH), a dopamine agonist, used here to enhance the salience of the drug-related cues (Aim 2)...
- Neurobiological Mechanisms of Treatment Response in Geriatric DepressionHelen Lavretsky; Fiscal Year: 2013..emission tomography (PET) that is relevant to her ongoing investigation of the dopaminergic mechanisms of methylphenidate in geriatric depression;(2) extend her knowledge and skills to the use of functional MRI (fMRI) with the ..
- Extended Release Mixed Amphetamine Salts for Adult ADHD and Cocaine DependenceFrances Rudnick Levin; Fiscal Year: 2010..To date studies of immediate and sustained-release methylphenidate for adult cocaine-dependent individuals with ADHD have produced mixed results, suggesting that high doses of ..
- Early Exposure to Stimulants as a Risk Factor for Substance AbuseLinda J Porrino; Fiscal Year: 2010..Most of the studies conducted in children and adults with ADHD have suggested that medication with methylphenidate or amphetamine has either no effect or can be protectivefrom substance abuse disorders...
- COGNITIVE ASPECTS OF ADDICTION-RELATED BEHAVIORKathleen M Kantak; Fiscal Year: 2013..the prefrontal cortex during adolescence that is prevented by treatment with either the stimulant medication methylphenidate or the non-stimulant medication atomoxetine;2) augmented vulnerability to cocaine addiction during adulthood ..
- Psychostimulants and Monoamine TransportersANNETTE FLECKENSTEIN; Fiscal Year: 2012DESCRIPTION (provided by applicant): Methylphenidate (MPD) is a plasmalemmal dopamine (DA) transporter (DAT) inhibitor used to treat attention deficit hyperactivity disorder...
- Monoamine Transporter Structure-Function StudiesCHRISTOPHER SURRATT; Fiscal Year: 2007..g., dopamine, serotonin, various amphetamines) and inhibitor (e.g., cocaine, methylphenidate) recognition...
- NEUROCHEMICAL BASIS OF SLEEP HOMEOSTASISWilliam Dement; Fiscal Year: 2001..Waking from stimulants (methamphetamine and methylphenidate) also induce CSR...
- Role of astroglia in cocaine-induced neurotoxicityHelene Benveniste; Fiscal Year: 2009..Ca++]i following intravenous administration of cocaine and the local anesthetic lidocaine but not with methylphenidate indicating that cocaine's local anesthetic properties but not its catecholaminergic actions underlie ..
- HYPERKINETIC BOYS AND THEIR SIBLINGS AS YOUNG ADULTSJan Loney; Fiscal Year: 1991..The samples include: a) an Early Medicated group (referred between 1967-1972 and methylphenidate); b) a Transitional Medicated group (referred between 1972-1975 and treated primarily with methylphenidate); ..
- Methylphenidate and Binge Eating Disorder in Obese HumansJennifer Nasser; Fiscal Year: 2009..We propose to evaluate the effect of central dopamine manipulation (using methylphenidate, a drug that increases brain dopamine signaling) on binge eating behavior in obese women measured by food ..
- ACUPUNCTURE POINT TREATMENT FOR ADHANEIL SONENKLAR; Fiscal Year: 1993..It will investigate the effects of acupuncture point therapy, methylphenidate, placebo and the two active treatments combined...
- MEDICATED & UNMEDICATED ADHD BOYS AT MIDLIFE (35 TO 45)Jan Loney; Fiscal Year: 2005..four groups: (1) 164 probands who were medicated as children with a central nervous system stimulant such as methylphenidate for an average of 3 years (the MED group), (2) 50 probands who were never medicated (UNMED), (3) 75 ..
- CLONIDINE IN ADHDFloyd Sallee; Fiscal Year: 2005..Rationales for combination with methylphenidate (MPH) are that it may be synergistic, may extend the stimulant effect, and/or that CLON may address certain ..
- Transcriptomic Analysis of Therapeutics in Brain TraumaC Dixon; Fiscal Year: 2005..our experimental model of TBI, and found three to be beneficial: amantadine hydroehloride, bromoeriptine, and methylphenidate. While all are putative dopaminergic agonists, they have varying degrees of specificity to DA systems...