mepivacaine

Summary

Summary: A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)

Top Publications

  1. ncbi Pain perception and utility: a comparison of the syringe and computerized local injection techniques
    J W Nicholson
    Department of Restorative Dentistry, University of Texas Health Science Center, San Antonio, USA
    Gen Dent 49:167-73. 2001
  2. ncbi The effects of ultrasound guidance and neurostimulation on the minimum effective anesthetic volume of mepivacaine 1.5% required to block the sciatic nerve using the subgluteal approach
    Giorgio Danelli
    Department of Anesthesia, Intensive Care and Pain Therapy, University Hospital of Parma, 43100 Parma, PR, Italy
    Anesth Analg 109:1674-8. 2009
  3. ncbi Mepivacaine-induced contraction is attenuated by endothelial nitric oxide release in isolated rat aorta
    Hui Jin Sung
    Department of Anesthesiology, Charmjoeun Obstetrics and Gynecology Clinic, Jinju, Korea
    Can J Physiol Pharmacol 90:863-72. 2012
  4. ncbi Anesthetic efficacy and heart rate effects of the supplemental intraosseous injection of 2% mepivacaine with 1:20,000 levonordefrin
    A Guglielmo
    The Ohio State University, Columbus 43210, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 87:284-93. 1999
  5. ncbi Lipid emulsion improves recovery from bupivacaine-induced cardiac arrest, but not from ropivacaine- or mepivacaine-induced cardiac arrest
    York A Zausig
    University of Regensburg, Department of Anaesthesiology, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Anesth Analg 109:1323-6. 2009
  6. ncbi Toxicity of local anaesthetics
    B Cox
    Department of Anesthesiology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Best Pract Res Clin Anaesthesiol 17:111-36. 2003
  7. ncbi The neurotoxicity of local anesthetics on growing neurons: a comparative study of lidocaine, bupivacaine, mepivacaine, and ropivacaine
    Inas A M Radwan
    Department of Anesthesiology and Reanimatology, Gunma University School of Medicine, Maebashi, Gunma, Japan
    Anesth Analg 94:319-24, table of contents. 2002
  8. ncbi Tramadol added to 1.5% mepivacaine for axillary brachial plexus block improves postoperative analgesia dose-dependently
    Sébastien Robaux
    Department of Anesthesiology and Critical Care Medicine, Hopital Central, Nancy Cedex, Nimes Cedex 9, France
    Anesth Analg 98:1172-7, table of contents. 2004
  9. ncbi Mepivacaine-induced contraction involves phosphorylation of extracellular signal-regulated kinase through activation of the lipoxygenase pathway in isolated rat aortic smooth muscle
    Hyo Min Lee
    Department of Anesthesiology and Pain Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea
    Can J Physiol Pharmacol 91:285-94. 2013
  10. ncbi The cytotoxicity of bupivacaine, ropivacaine, and mepivacaine on human chondrocytes and cartilage
    Anita Breu
    Department of Anesthesiology, University Medical Center Regensburg, 93042 Regensburg, Germany
    Anesth Analg 117:514-22. 2013

Research Grants

Detail Information

Publications223 found, 100 shown here

  1. ncbi Pain perception and utility: a comparison of the syringe and computerized local injection techniques
    J W Nicholson
    Department of Restorative Dentistry, University of Texas Health Science Center, San Antonio, USA
    Gen Dent 49:167-73. 2001
    ..Reduced postoperative discomfort using the Wand for the inferior alveolar nerve block was significant. Both of the dentists in the study and those patients who stated a preference favored the Wand system...
  2. ncbi The effects of ultrasound guidance and neurostimulation on the minimum effective anesthetic volume of mepivacaine 1.5% required to block the sciatic nerve using the subgluteal approach
    Giorgio Danelli
    Department of Anesthesia, Intensive Care and Pain Therapy, University Hospital of Parma, 43100 Parma, PR, Italy
    Anesth Analg 109:1674-8. 2009
    We tested the hypothesis that ultrasound (US) guidance may reduce the minimum effective anesthetic volume (MEAV(50)) of 1.5% mepivacaine required to block the sciatic nerve with a subgluteal approach compared with neurostimulation (NS).
  3. ncbi Mepivacaine-induced contraction is attenuated by endothelial nitric oxide release in isolated rat aorta
    Hui Jin Sung
    Department of Anesthesiology, Charmjoeun Obstetrics and Gynecology Clinic, Jinju, Korea
    Can J Physiol Pharmacol 90:863-72. 2012
    b>Mepivacaine is an aminoamide-linked local anesthetic with an intermediate duration that intrinsically produces vasoconstriction both in vivo and in vitro...
  4. ncbi Anesthetic efficacy and heart rate effects of the supplemental intraosseous injection of 2% mepivacaine with 1:20,000 levonordefrin
    A Guglielmo
    The Ohio State University, Columbus 43210, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 87:284-93. 1999
    The purpose of this study was to determine the anesthetic efficacy and heart rate effects of a supplemental intraosseous injection of 2% mepivacaine with 1:20,000 levonordefrin.
  5. ncbi Lipid emulsion improves recovery from bupivacaine-induced cardiac arrest, but not from ropivacaine- or mepivacaine-induced cardiac arrest
    York A Zausig
    University of Regensburg, Department of Anaesthesiology, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Anesth Analg 109:1323-6. 2009
    ..As the postulated mechanism of action, the so-called "lipid sink" effect may depend on the lipophilicity of LAs. In this study, we investigated whether lipid effects differ with regard to the administered LAs...
  6. ncbi Toxicity of local anaesthetics
    B Cox
    Department of Anesthesiology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Best Pract Res Clin Anaesthesiol 17:111-36. 2003
    ..2 to 0.01%. Peripheral nerve blocks are associated with the highest incidence of systemic toxicity (7.5 per 10,000) and the lowest incidence of serious neural injury (1.9 per 10,000)...
  7. ncbi The neurotoxicity of local anesthetics on growing neurons: a comparative study of lidocaine, bupivacaine, mepivacaine, and ropivacaine
    Inas A M Radwan
    Department of Anesthesiology and Reanimatology, Gunma University School of Medicine, Maebashi, Gunma, Japan
    Anesth Analg 94:319-24, table of contents. 2002
    ..The effects of lidocaine, bupivacaine, mepivacaine, and ropivacaine were examined microscopically and quantitatively assessed using the growth cone collapse assay...
  8. ncbi Tramadol added to 1.5% mepivacaine for axillary brachial plexus block improves postoperative analgesia dose-dependently
    Sébastien Robaux
    Department of Anesthesiology and Critical Care Medicine, Hopital Central, Nancy Cedex, Nimes Cedex 9, France
    Anesth Analg 98:1172-7, table of contents. 2004
    ..All patients received 1.5% mepivacaine 40 mL plus a study solution containing either isotonic sodium chloride (Group P, n = 17), tramadol 40 mg (Group ..
  9. ncbi Mepivacaine-induced contraction involves phosphorylation of extracellular signal-regulated kinase through activation of the lipoxygenase pathway in isolated rat aortic smooth muscle
    Hyo Min Lee
    Department of Anesthesiology and Pain Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea
    Can J Physiol Pharmacol 91:285-94. 2013
    b>Mepivacaine is an aminoamide local anesthetic with an intermediate duration that intrinsically produces vasoconstriction both in vivo and in vitro...
  10. ncbi The cytotoxicity of bupivacaine, ropivacaine, and mepivacaine on human chondrocytes and cartilage
    Anita Breu
    Department of Anesthesiology, University Medical Center Regensburg, 93042 Regensburg, Germany
    Anesth Analg 117:514-22. 2013
    ..In this study, we assessed the chondrotoxic effects of mepivacaine, ropivacaine, and bupivacaine...
  11. ncbi [Systemic toxicity with mepivacaine following axillary block in a patient with terminal kidney failure]
    I Tanoubi
    Département d anesthésie douleur, Groupe Hospitalo Universitaire Caremeau, place du Professeur Debré, 30000 Nimes, France
    Ann Fr Anesth Reanim 25:33-5. 2006
    As onset time and duration of sensory block are intermediate, mepivacaine is widely used for regional anaesthesia. Few reports of systemic adverse effects are available following nerve blockade with mepivacaine...
  12. ncbi Epidural migration of new methylene blue in 0.9% sodium chloride solution or 2% mepivacaine solution following injection into the first intercoccygeal space in foal cadavers and anesthetized foals undergoing laparoscopy
    Jennifer L Lansdowne
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada
    Am J Vet Res 66:1324-9. 2005
    ....
  13. ncbi Spinal procaine is less neurotoxic than mepivacaine, prilocaine and bupivacaine in rats
    Tamie Takenami
    Department of Anesthesiology, Kitasato University School of Medicine, Japan
    Reg Anesth Pain Med 34:189-95. 2009
    ..Therefore, we compared the histologic and functional changes induced by intrathecal injection of prilocaine, mepivacaine, procaine, and bupivacaine in rats.
  14. ncbi The effects of bupivacaine, ropivacaine and mepivacaine on the contractility of rat myometrium
    G Arici
    Akdeniz University Faculty of Medicine, Departments of Anesthesiology and Reanimation, Antalya, Turkey
    Int J Obstet Anesth 13:95-8. 2004
    ..We determined the effects of bupivacaine, ropivacaine and mepivacaine on the contractility of isolated pregnant rat uterine muscle strips...
  15. ncbi Procaine and mepivacaine have less toxicity in vitro than other clinically used local anesthetics
    Toshiharu Kasaba
    Department of Anesthesiology, Miyazaki Medical College, Kiyotake cho, Japan
    Anesth Analg 97:85-90, table of contents. 2003
    ..We compared the neurotoxicity of procaine, mepivacaine, ropivacaine, bupivacaine, lidocaine, tetracaine, and dibucaine by using cultured neurons from the freshwater ..
  16. ncbi Epidurally administered mepivacaine delays recovery of train-of-four ratio from vecuronium-induced neuromuscular block
    T Suzuki
    Department of Anaesthesiology, Surugadai Nihon University Hospital, 1 8 13, Kanda Surugadai, Chiyoda ku, Tokyo, 101 8309, Japan
    Br J Anaesth 99:721-5. 2007
    The aim of this study was to examine the efficacy of epidurally administered mepivacaine on recovery from vecuronium-induced neuromuscular block.
  17. ncbi Dexamethasone added to mepivacaine prolongs the duration of analgesia after supraclavicular brachial plexus blockade
    Simon J Parrington
    Department of Anesthesia and Pain Management, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Reg Anesth Pain Med 35:422-6. 2010
    ..We hypothesized that the addition of dexamethasone to mepivacaine would prolong the duration of analgesia after ultrasound-guided supraclavicular brachial plexus block for ..
  18. ncbi Linear scleroderma after contusion and injection of mepivacaine hydrochloride
    Takashi Ueda
    Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Japan
    Dermatol Online J 16:11. 2010
    A 36-year-old woman initially was treated for a contusion by local injection of mepivacaine hydrochloride into the left dorsum of the foot...
  19. ncbi Long-term absence of sensitization to mepivacaine as assessed by a diagnostic protocol including patch testing
    C Astarita
    Section of Allergology and Clinical Immunology, Division of Internal Medicine, F Magrassi Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, Naples, Italy
    Clin Exp Allergy 31:1762-70. 2001
    ..Prospective assessment of non-reactivity to local anaesthetics is a frequent reason for allergy consultation...
  20. ncbi Acute toxicity of local anesthetic ropivacaine and mepivacaine during a combined lumbar plexus and sciatic block for hip surgery
    Ch Mullanu
    Department of Anesthesiology, University of St Luc Hospital, Brussels, Belgium
    Acta Anaesthesiol Belg 53:221-3. 2002
    ..We report a case of acute toxicity resulting in the injection of local anesthetics Ropivacaine and Mepivacaine in elderly patient...
  21. ncbi The analgesic efficacy and safety of intra-articular morphine and mepivicaine following temporomandibular joint arthroplasty
    John R Zuniga
    Department of Surgery, Division of Oral and Maxillofacial Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Oral Maxillofac Surg 65:1477-85. 2007
    This study was designed to evaluate the efficacy and safety of intra-articular morphine, mepivacaine, or a combination of both in the management of temporomandibular joint (TMJ) pain in a 24-hour period after arthroplasty.
  22. ncbi Clonidine as adjuvant for mepivacaine, ropivacaine and bupivacaine in axillary, perivascular brachial plexus block
    W Erlacher
    Department of Anaesthesia and Intensive Care, Hospital Lainz, Vienna, Austria
    Can J Anaesth 48:522-5. 2001
    To evaluate the effects of clonidine on three local anesthetics (mepivacaine 1%, ropivacaine 0.75% and bupivacaine 0.5%) with comparable potency and almost the same concentration-response relationship.
  23. ncbi Efficacy of liposome-encapsulated mepivacaine for infiltrative anesthesia in volunteers
    Giovana R Tofoli
    UNIFAG Clinical Pharmacology and Gastroenterology Unit, Sao Francisco University, Braganca Paulista, Sao Paulo, Brazil
    J Liposome Res 21:88-94. 2011
    ..study evaluated the efficacy and pain sensitivity evoked by a previously reported liposome-encapsulated mepivacaine formulation (Araujo et al., 2004). Thirty healthy volunteers received an intraoral injection (1...
  24. ncbi Membrane effects of ropivacaine compared with those of bupivacaine and mepivacaine
    Maki Mizogami
    Department of Anesthesiology, Asahi University School of Dentistry, Hozumi, Gifu, Japan
    Fundam Clin Pharmacol 16:325-30. 2002
    We compared the effects of ropivacaine, bupivacaine and mepivacaine on membrane lipids in an attempt to determine the anaesthetic mechanism of ropivacaine with structure-dependent potency...
  25. doi IgE-mediated reaction to mepivacaine
    Lennart Venemalm
    J Allergy Clin Immunol 121:1058-9. 2008
  26. ncbi A prospective, randomized, double-blind comparison of 2% lidocaine with 1:100,000 and 1:50,000 epinephrine and 3% mepivacaine for maxillary infiltrations
    Rick Mason
    Private Practice, State College, PA, USA
    J Endod 35:1173-7. 2009
    The purpose of this prospective, randomized, double-blind crossover study was to evaluate the anesthetic efficacy of 2% lidocaine with 1:100,000 and 1:50,000 epinephrine and 3% mepivacaine in maxillary lateral incisors and first molars.
  27. ncbi Efficacy and safety of hyaluronidase 75 IU as an adjuvant to mepivacaine for retrobulbar anesthesia in cataract surgery
    Matthias Remy
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
    J Cataract Refract Surg 34:1966-9. 2008
    To evaluate the efficacy and safety of hyaluronidase as an adjuvant to mepivacaine for retrobulbar anesthesia in cataract surgery.
  28. ncbi Enhanced local anesthetic action of mepivacaine from the bioadhesive gels
    Cheong Weon Cho
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Pak J Pharm Sci 24:87-93. 2011
    b>Mepivacaine, an amide-type local anesthetic, has been used to relieve local pain. Among the many drug delivery systems, transdermal drug delivery has some advantages, as it provides controlled drug delivery for an extended period of time...
  29. ncbi Pulmonary function changes after interscalene brachial plexus anesthesia with 0.5% and 0.75% ropivacaine: a double-blinded comparison with 2% mepivacaine
    A Casati
    Department of Anesthesiology, University of Milan, Italy
    Anesth Analg 88:587-92. 1999
    ..5% and 0.75% ropivacaine with 2% mepivacaine to determine their effects on respiratory function during interscalene brachial plexus (IBP) anesthesia...
  30. ncbi Comparison of the cytotoxic effects of bupivacaine, lidocaine, and mepivacaine in equine articular chondrocytes
    Jinuk Park
    Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea
    Vet Anaesth Analg 38:127-33. 2011
    To compare the chondrotoxicity of bupivacaine, lidocaine, and mepivacaine in equine articular chondrocytes in vitro.
  31. ncbi Tramadol added to mepivacaine prolongs the duration of an axillary brachial plexus blockade
    S Kapral
    Department of Anesthesia and General Intensive Care, University of Vienna, Austria
    Anesth Analg 88:853-6. 1999
    ..We designed a prospective, controlled, double-blinded study to assess the impact of tramadol added to mepivacaine on the duration of an axillary brachial plexus blockade...
  32. ncbi Ropivacaine or 2% mepivacaine for lower limb peripheral nerve blocks. Study Group on Orthopedic Anesthesia of the Italian Society of Anesthesia, Analgesia, and Intensive Care
    A Casati
    University of Milan, Italy
    Anesthesiology 90:1047-52. 1999
    Intra- and postoperative clinical properties of sciatic-femoral nerve block performed with either ropivacaine at different concentrations or mepivacaine have been evaluated in a multicenter, randomized, blinded study.
  33. ncbi Cross-reactivity among amide-type local anesthetics in a case of allergy to mepivacaine
    P Gonzalez-Delgado
    Sección Alergia, Hospital General de Alicante, Aliccante, Spain
    J Investig Allergol Clin Immunol 16:311-3. 2006
    ..man who suffered itching and generalized urticaria with facial angioedema 15 minutes after administration of mepivacaine. Skin tests revealed a strong positive reaction to mepivacaine, lidocaine, and ropivacaine, but negative ..
  34. ncbi Cardiovascular effects of intraosseous injections of 2 percent lidocaine with 1:100,000 epinephrine and 3 percent mepivacaine
    K Replogle
    Graduate Endodontics, Ohio State University, Columbus 43210, USA
    J Am Dent Assoc 130:649-57. 1999
    ..The purpose of this study was to determine the cardiovascular effects of an i.o. injection of 2 percent lidocaine with 1:100,000 epinephrine and 3 percent mepivacaine.
  35. ncbi Caruncle single injection episcleral (Sub-tenon) anesthesia for cataract surgery: mepivacaine versus a lidocaine-bupivacaine mixture
    J Ripart
    Département anesthésie douleur, Centre Hospitalier Universitaire, Nimes, France
    Anesth Analg 91:107-9. 2000
    We compared the quality of anesthesia provided by mepivacaine 2% or a mixture of lidocaine 2%-bupivacaine 0.5%, both with hyaluronidase, in caruncle single-injection episcleral (sub-Tenon) anesthesia...
  36. ncbi Articaine and mepivacaine efficacy in postoperative analgesia for lower third molar removal: a double-blind, randomized, crossover study
    Bella L Colombini
    Bauru School of Dentistry, Sao Paulo, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:169-74. 2006
    Comparison of the clinical efficacy of 4% articaine in relation to 2% mepivacaine, both with 1:100,000 epinephrine, in the prevention of postoperative pain after lower third molar removal.
  37. ncbi The enhancement of sensory blockade by clonidine selectively added to mepivacaine after midhumeral block
    H Iskandar
    Clinique chirurgicale Bordeaux Mérignac, Mérignac, France
    Anesth Analg 93:771-5. 2001
    ..These patients were randomly allocated into two groups. The Control group (n = 28) received 10 mL of plain mepivacaine 1.5% for each nerve (median, musculocutaneous, ulnar, and radial)...
  38. ncbi Comparison of hemodynamic effects of lidocaine, prilocaine and mepivacaine solutions without vasoconstrictor in hypertensive patients
    Bahadir Ezmek
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Yeditepe University, Istanbul, Turkey
    J Appl Oral Sci 18:354-9. 2010
    ..The aim of this study was to compare hemodynamic effects of three different local anesthetics without vasoconstrictors during tooth extraction in hypertensive patients...
  39. ncbi A prospective, randomized, double-blind comparison of the anesthetic efficacy of two percent lidocaine with 1:100,000 and 1:50,000 epinephrine and three percent mepivacaine in the intraoral, infraorbital nerve block
    Gerhard Berberich
    Division of Endodontics, College of Dentistry, The Ohio State University, Columbus, Ohio 43210, USA
    J Endod 35:1498-504. 2009
    ..of this prospective, randomized, double-blind study was to compare the anesthetic efficacy of 2% lidocaine with 1:100,000 epinephrine, 2% lidocaine with 1:50,000 epinephrine, and 3% mepivacaine in the intraoral, infraorbital nerve block.
  40. ncbi Tremor of the forearm during performance of axillary brachial plexus block
    Sreenivasa S Moorthy
    Reg Anesth Pain Med 29:510. 2004
  41. ncbi The infraclavicular block is a useful technique for emergency upper extremity analgesia
    Regis Fuzier
    Can J Anaesth 51:191-2. 2004
  42. ncbi Delayed-type hypersensitivity to amide local anesthetics
    S Duque
    Allergy Unit, Hospital Sierrallana, Torrelavega, Spain
    Allergol Immunopathol (Madr) 32:233-4. 2004
    ..a 54-year-old woman who suffered eczematous eruptions on her face after the administration of lidocaine and mepivacaine for dental surgeries...
  43. ncbi Acute neck cellulitis and mediastinitis complicating a continuous interscalene block
    Xavier Capdevila
    Department of Anesthesiology and Critical Care Medicine, Lapeyronie University Hospital, Avenue du Doyen G Giraud, Montpellier, France
    Anesth Analg 107:1419-21. 2008
    ..A continuous interscalene block was done preoperatively and 20 mL of 0.5% bupivacaine and 20 mL of 2% mepivacaine were injected through the catheter...
  44. ncbi Injection pain and postinjection pain of the palatal-anterior superior alveolar injection, administered with the Wand Plus system, comparing 2% lidocaine with 1:100,000 epinephrine to 3% mepivacaine
    John Nusstein
    Deparment of Endodontic, Ohio State University, Columbus, 43218 2357, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:164-72. 2004
    ..study was to compare injection pain and postinjection pain of 2% lidocaine with 1:100,000 epinephrine and 3% mepivacaine using the computer-assisted Wand Plus injection system to administer the palatal-anterior superior alveolar (P-..
  45. ncbi Adding methylprednisolone to local anesthetic increases the duration of axillary block
    Thomas Stan
    Reg Anesth Pain Med 29:380-1. 2004
  46. ncbi Bilateral anesthesia into Spix's spine. Ten years' experience
    C Arcuri
    Department of Dentistry and Stomatology, Fatebenefratelli Hospital, Tor Vergata University of Rome, Rome, Italy
    Minerva Stomatol 53:93-9. 2004
    ..The aim of this study is therefore to eliminate any doubt about executing a bilateral anaesthesia to Spix's spine for the extraction, in inclusion and impacted of the inferior wisdom teeth...
  47. ncbi Increased success rate with infraclavicular brachial plexus block using a dual-injection technique
    J Rodriguez
    Department of Anesthesiology, Complexo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain
    J Clin Anesth 16:251-6. 2004
    ....
  48. ncbi Development of a technique for continuous perineural blockade of the palmar nerves in the distal equine thoracic limb
    Bernd Driessen
    Department of Clinical Studies, New Bolton Center, University of Pennsylvania, School of Veterinary Medicine, PA 19348, USA
    Vet Anaesth Analg 35:432-48. 2008
    ....
  49. ncbi The bifid axillary artery
    Paul E Bigeleisen
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Clin Anesth 16:224-5. 2004
    ..Because of neurologic anomalies associated with this vascular variation, an interscalene block was chosen for the procedure. The clinical implications of a bifid axillary artery when an axillary block is contemplated are discussed...
  50. ncbi Selective diagnostic cervical nerve root block--correlation with clinical symptoms and MRI-pathology
    L Anderberg
    Department of Neurosurgery, University Hospital, Lund, Sweden
    Acta Neurochir (Wien) 146:559-65; discussion 565. 2004
    ....
  51. ncbi Encapsulation of mepivacaine prolongs the analgesia provided by sciatic nerve blockade in mice
    Daniele R de Araujo
    Department of Biochemistry, Institute of Biology, State University of Campinas, Sao Paulo, Brazil
    Can J Anaesth 51:566-72. 2004
    ..This study aimed to prepare, characterize and evaluate in vivo drug-delivery systems, composed of large unilamellar liposomes (LUV), for bupivacaine (BVC) and mepivacaine (MVC).
  52. ncbi Electrical nerve stimulation or ultrasound guidance for lateral sagittal infraclavicular blocks: a randomized, controlled, observer-blinded, comparative study
    Axel R Sauter
    Faculty of Medicine, University of Oslo, Department of Anesthesiology, Rikshospitalet University Hospital, 0027 Oslo, Norway
    Anesth Analg 106:1910-5. 2008
    ..Ultrasound guidance is frequently used to perform infraclavicular brachial plexus blocks. In this study, we compared electrical nerve stimulation and ultrasound guidance for the lateral sagittal infraclavicular block...
  53. pmc Feasibility of ultrasound-guided peripheral nerve block catheters for pain control on pediatric medical missions in developing countries
    Edward R Mariano
    Department of Anesthesia, University of California, San Diego Medical Center, San Diego, CA, USA
    Paediatr Anaesth 18:598-601. 2008
    ..We present a series of successful cases employing ultrasound-guided CPNB for postoperative analgesia on medical missions and discuss the impact of this technology on present and future patients in underserved countries...
  54. ncbi Median versus musculocutaneous nerve response with single-injection infraclavicular coracoid block
    Jaime Rodriguez
    Department of Anesthesiology, Complexo Hospitalario Universitario de Santiago, s n 15706, Santiago de Compostela, Spain
    Reg Anesth Pain Med 29:534-8; discussion 520-3. 2004
    ..The aim of this study was to investigate whether elicitation of a median or of a musculocutaneous-type nerve response influenced the quality of anesthesia...
  55. ncbi A subgluteal approach to the sciatic nerve in adults at 10 cm from the midline
    Carlo D Franco
    Department of Anesthesiology and Pain Management John H Stroger, Jr Hospital of Cook County, Chicago, IL 60612, USA
    Reg Anesth Pain Med 31:215-20. 2006
    ..The anatomic basis for that study suggested that a subgluteal block could also be accomplished in a similar fashion...
  56. ncbi Analysis of the antimicrobial activity of local anaesthetics used for dental analgesia
    Klaus Pelz
    Institut fuer Mikrobiologie und Hygiene, Albert Ludwigs Universitaet Freiburg, D 79104 Freiburg, Germany
    J Med Microbiol 57:88-94. 2008
    ..components [Ultracaine D-S (articaine hydrochloride), Carbostesin (bupivacaine hydrochloride), Scandicaine (mepivacaine hydrochloride), Xylonest (prilocaine hydrochloride), Xylocaine (lidocaine hydrochloride), Hostacaine (..
  57. ncbi Perivascular axillary brachial plexus block and patient positioning: the influence of a lateral, head-down position
    O Orlowski
    Department of Anaesthesiology and Intensive Care, University of Munster, Germany
    Anaesthesia 61:528-34. 2006
    ..were left in the allocated position for 30 min after an axillary block had been performed with alkalinised mepivacaine 1% 49.5 ml...
  58. ncbi Injection pain of prilocaine plain, mepivacaine plain, articaine with epinephrine, and lidocaine with epinephrine
    Michael J Wahl
    Department of Psychology, Temple University, Philadelphia, Pennsylvania, USA
    Gen Dent 54:168-71. 2006
    ..received one of four different local anesthetics (articaine with epinephrine, lidocaine with epinephrine, mepivacaine plain, or prilocaine plain) via a maxillary buccal infiltration, palatal infiltration, or inferior alveolar ..
  59. ncbi Transscalene brachial plexus block: a new posterolateral approach for brachial plexus block
    Hoang C Nguyen
    Department of Anesthesiology and Intensive Care Medicine, Asklepios Klinik Barmbek, Hamburg, Germany
    Anesth Analg 105:872-5. 2007
    ..Further studies are needed to compare the transscalene brachial plexus block with other approaches to the brachial plexus...
  60. ncbi Seminars: local and regional anesthesia for thyroid surgery
    Nimmi Arora
    Department of Surgery, New York Presbyterian Hospital, Weill Medical College of Cornell, New York, New York 10021, USA
    J Surg Oncol 94:708-13. 2006
    ..Over the past decade, there has been a renewed interest in the art of performing thyroidectomy under local/regional anesthesia in some specialized high volume endocrine surgery centers...
  61. ncbi [Characteristics of mepivacaine axillary brachial plexus block performed at 2800 m of altitude]
    R Fuzier
    Service d Orthopédie et de Traumatologie, département d anesthésie, CHU Purpan, place Docteutr Baylac, TSA 40031, 31059 Toulouse cedex 09, France
    Ann Fr Anesth Reanim 26:17-22. 2007
    ..We evaluated the feasibility and pharmacodynamic profile of axillary brachial plexus nerve blocks performed in high altitude...
  62. ncbi Calculating the maximum recommended dose of local anesthetic
    Joel M Weaver
    Section of Oral and Maxillofacial Surgery, Pathology and Anesthesiology, Department of Anesthesiology, College of Medicine and Public Health, The Ohio State University, Columbus 43218, USA
    J Calif Dent Assoc 35:61-3. 2007
    ..By calculating the specific dose limit from the maximum recommended dose for each patient, the chances of a local anesthetic overdose can be significantly reduced...
  63. ncbi [Addition of sodium bicarbonate and/or clonidine to mepivacaine: influence on axillary brachial plexus block characteristics]
    V Contreras-Dominguez
    Servicio de Anestesiologia, Hospital Clinico Regional de Concepción, Facultad de Medicina, Universidad de Concepcion, Chile
    Rev Esp Anestesiol Reanim 53:532-7. 2006
    ..Adding a variety of coadjuvant drugs has been shown to improve results. This study evaluated the addition of sodium bicarbonate (NaHCO3) and/or clonidine to mepivacaine for performing the block.
  64. ncbi Spread of injectate associated with radial or median nerve-type motor response during infraclavicular brachial-plexus block: an ultrasound evaluation
    Sébastien Bloc
    Department of Anesthesiology, Private Hospital, Claude Galien, Quincy sous Snart, Paris, France
    Reg Anesth Pain Med 32:130-5. 2007
    ..5% mepivacaine.
  65. ncbi A comparison of mepivacaine versus lidocaine for episcleral (sub-tenon's) block for cataract surgery in an ambulatory setting
    Jacques Ripart
    Anesthesia Department, Anesthesia Emergency Division, Centre Hospitalier Universitaire de Nimes, Nimes, France
    Reg Anesth Pain Med 31:206-10. 2006
    ..Lidocaine is classically assumed to have shorter duration than mepivacaine. Therefore, lidocaine alone might be considered as an alternative to mepivacaine.
  66. ncbi A prospective randomized comparison of spinal versus local anesthesia with propofol infusion for knee arthroscopy
    Warren R Dunn
    Vanderbilt Sports Medicine Center, Department of Orthopaedics and Rehabilitation, Vanderbilt University, Nashville, Tennessee, USA
    Arthroscopy 22:479-83. 2006
    ....
  67. ncbi Articaine is more effective than lidocaine or mepivacaine in rat sensory nerve conduction block in vitro
    I Potocnik
    Department of Restorative Dentistry and Endodontics, University of Ljubljana, Dental School, Hrvatski trg 6, 1000 Ljubljana, Slovenia
    J Dent Res 85:162-6. 2006
    ..These results are discussed in the light of recent clinical reports finding no differences in the effectiveness between 4% articaine and 2% lidocaine regarding the inferior alveolar nerve block...
  68. ncbi The wand versus traditional injection for mandibular nerve block in children and adolescents: perceived pain and time of onset
    A M Palm
    Municipal Dental Service for Children and Adolescents, Frederikssund, Denmark
    Pediatr Dent 26:481-4. 2004
    ....
  69. ncbi Intravenous lipid infusion in the successful resuscitation of local anesthetic-induced cardiovascular collapse after supraclavicular brachial plexus block
    Julio A Warren
    Department of Anesthesiology, University of Alabama, School of Medicine, Birmingham, AL, USA
    Anesth Analg 106:1578-80, table of contents. 2008
    ..infusion of local anesthetic-induced cardiovascular toxicity after supraclavicular brachial plexus block with mepivacaine and bupivacaine...
  70. ncbi Comparison of lidocaine 2% gel versus retrobulbar anaesthesia for implantation of Ahmed glaucoma drainage
    Gema Rebolleda
    Ophthalmology Department, Glaucoma Unit, Hospital Ramon y Cajal, University of Alcala, Madrid, Spain
    Acta Ophthalmol Scand 83:201-5. 2005
    ..To compare patient comfort and the efficacy of lidocaine 2% gel versus retrobulbar anaesthesia for Ahmed glaucoma implant surgery...
  71. ncbi Reversal of central nervous system and cardiac toxicity after local anesthetic intoxication by lipid emulsion injection
    Rainer J Litz
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, University of Technology, Fetscherstr 74, 01307 Dresden, Germany
    Anesth Analg 106:1575-7, table of contents. 2008
    ..Twenty minutes after infraclavicular injection of 30 mL of mepivacaine 1% (Scandicain) and 5 min after supplementation of 10 mL of prilocaine 1% (Xylonest) using an axillary approach,..
  72. ncbi The effects of general anesthesia on whole body and regional pharmacokinetics of local anesthetics at toxic doses
    Susan E Copeland
    Department of Anaesthesia and Pain Management, University of Sydney at Royal North Shore Hospital, Sydney NSW 2065, Australia
    Anesth Analg 106:1440-9, table of contents. 2008
    ..In this study, we determined the influence of general anesthesia on the pharmacokinetics of six local anesthetics administered i.v. at approximately the highest recommended doses...
  73. ncbi The effects of general anesthesia on the central nervous and cardiovascular system toxicity of local anesthetics
    Susan E Copeland
    Department of Anaesthesia and Pain Management, University of Sydney at Royal North Shore Hospital, Sydney NSW 2065, Australia
    Anesth Analg 106:1429-39, table of contents. 2008
    ..We determined the influence of halothane/O(2) anesthesia on cardiovascular and central nervous system (CNS) toxic responses to six amide-type local anesthetics administered i.v....
  74. ncbi [Efficiency of secondary posterior trunk single stimulation, low volume infraclavicular plexus block for upper limb surgery]
    S Bloc
    hôpital privé Claude Galien, 20, route de Boussy, 91480 Quincy sous Sénart, France
    Ann Fr Anesth Reanim 24:1329-33. 2005
    To assess the efficiency of a posterior secondary trunk single stimulation, low volume (30 ml 1.5% mepivacaine) infraclavicular brachial plexus block (ICB) technique.
  75. ncbi Needle-less local anesthesia: clinical evaluation of the effectiveness of the jet anesthesia Injex in local anesthesia in dentistry
    Nikolaos N Dabarakis
    Department of Oral Surgery, Implantology, and Roentgenology, Dental School, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Quintessence Int 38:E572-6. 2007
    ..To clinically evaluate the jet injection Injex (Rösch AG Medizintechnik) using 2 different anesthetic solutions, and to compare the jet injection and the standard needle injection techniques...
  76. ncbi Plasma catecholamine concentrations and hemodynamic responses to vasoconstrictor during conventional or Gow-Gates mandibular anesthesia
    Adriana M Viana
    Department of Oral and Maxillofacial Surgery, Universidade de Sao Paulo, Sao Paulo, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:415-9. 2005
    ..Thus, the influence of mandibular anesthesia technique on hemodynamic and plasma responses to epinephrine-containing local anesthetics was investigated...
  77. ncbi Nerve blocks at the wrist for carpal tunnel release revisited: the use of sensory-nerve and motor-nerve stimulation techniques
    Philippe Macaire
    Department of Anesthesiology, Centre Clinical, Soyaux, France
    Reg Anesth Pain Med 30:536-40. 2005
    ..A control group of patients who received blinded injections was analyzed and compared post hoc...
  78. ncbi Motor and sensory block of both upper and lower extremities following axillary brachial plexus block using a transarterial approach
    H K Shinn
    Acta Anaesthesiol Scand 51:514. 2007
  79. ncbi Comparison of three different volumes of mepivacaine in axillary plexus block using multiple nerve stimulation
    A Serradell
    Service of Anaesthesiology and Resuscitation, Hospital de la Creu Roja, Dos de Maig 301, E 08025 Barcelona, Spain
    Br J Anaesth 91:519-24. 2003
    ..This randomized double-blind study was conducted to compare the effectiveness of three different volumes of mepivacaine 10 mg x ml(-1) in patients undergoing elective distal upper limb surgery under axillary brachial plexus block ..
  80. ncbi Continuous infraclavicular brachial plexus block in a child
    Phoebe Fisher
    Department of Anesthesiology, Alfred I duPont Hospital for Children, Nemours Children s Clinic, Wilmington, DE, USA
    Paediatr Anaesth 16:884-6. 2006
    ..In this case report, we present the successful placement and use of a continuous infraclavicular catheter in a child undergoing upper extremity surgery...
  81. ncbi High doses of mepivacaine for brachial plexus block in patients with end-stage chronic renal failure. A pilot study
    J Rodriguez
    Department of Anaesthesiology and Postoperative Intensive Care, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    Eur J Anaesthesiol 18:171-6. 2001
    ..The aim of this study was to measure mepivacaine plasma concentrations after axillary block with 650 mg plain mepivacaine in patients with end-stage chronic ..
  82. ncbi Pediatric caudal block with mepivacaine, bupivacaine or a mixture of both drugs: requirement for postoperative analgesia and plasma concentration of local anesthetics
    Y Hashizume
    First Department of Anesthesiology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    J Clin Anesth 13:30-4. 2001
    STUDY OBJECTIVES: To assess the effects of pediatric caudal block using mepivacaine, bupivacaine, or a mixture of both drugs on postoperative analgesia, and to examine plasma concentrations of the local anesthetics after caudal injection...
  83. ncbi Hemodynamic assessment of local anesthetic administration by laser Doppler flowmetry
    E M Fernieini
    School of Dental Medicine, University of Connecticut, 263 Farmington Ave, Farmington, CT 06030, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:526-30. 2001
    ..8 mL lidocaine (2%) with epinephrine (1:100,000) and mepivacaine (3%)...
  84. ncbi Pulsioxymetry monitorization during lower third molar extraction. A comparative study of three local anesthetics with epinephrine 1:100,000
    R Mestre Aspa
    ,
    Med Oral 6:195-204. 2001
    ..third molar extractions under the effect of three different local anesthetics (4% articaine, 2% lidocaine, 2% mepivacaine) with the same epinephrine concentration (1:100,000)...
  85. ncbi Anesthetic efficacy of the palatal-anterior superior alveolar injection
    Yvette Burns
    College of Dentistry, The Ohio State University, Columbus, USA
    J Am Dent Assoc 135:1269-76. 2004
    ..a prospective, randomized, double-blind study to compare the anesthetic efficacy of 2 percent lidocaine with 1:100,000 epinephrine and 3 percent mepivacaine using a computer-assisted injection system to administer the P-ASA injection.
  86. ncbi Local anesthesia: advances in agents and techniques
    J Mel Hawkins
    Continuing Education Program, Faculty of Dentistry, University of Toronto, 4800 Leslie Street, Suite 111, Toronto, Ontario, Canada M2J2K9
    Dent Clin North Am 46:719-32, ix. 2002
    ..This article provides a brief review of the local anesthetic agents, formulations, and techniques used in dentistry with special emphasis on newly introduced agents and procedures...
  87. ncbi Continuous interscalene brachial plexus block for postoperative pain control at home: a randomized, double-blinded, placebo-controlled study
    Brian M Ilfeld
    Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL 32610 0254, USA
    Anesth Analg 96:1089-95, table of contents. 2003
    ....
  88. ncbi Infraclavicular block with lateral approach and nerve stimulation: extent of anesthesia and adverse effects
    C Jandard
    Service d Anesthesie Reanimation, Hopital Central, Nancy, Cedex, France
    Reg Anesth Pain Med 27:37-42. 2002
    ..The infraclavicular approach to the brachial plexus is little used despite theoretical advantages of the technique. Using a vertical paracoracoid approach, we assessed the extent of the sensory block and the incidence of adverse effects...
  89. ncbi A review of paresthesia in association with administration of local anesthesia
    James S Dower
    Department of Restorative Dentistry, University of the Pacific s School of Dentistry, USA
    Dent Today 22:64-9. 2003
  90. ncbi Optimal thoracotomy analgesia
    Jonathan A Richardson
    Ann Thorac Surg 76:978; author reply 978-9. 2003
  91. ncbi [Modified technique for transurethral resection of the prostate with suprapubic drainage and local anesthesia]
    J M Sánchez Zalabardo
    Servicio de Urologia, Hospital Clinico Universitario Lozano Blesa, Zaragoza
    Actas Urol Esp 27:216-20. 2003
    ..To establish a technique for transurethral resection of the prostate (TURP), combining the use of local anaesthesia with an Amplatz suprapubic tube, in patients at high surgical risk...
  92. ncbi Cytotoxicity of local anesthetics in human neuronal cells
    Rosalia Perez-Castro
    Department of Anesthesiology, NYU School of Medicine, New York, NY, USA
    Anesth Analg 108:997-1007. 2009
    ..However, it may contribute to cell death in combination with other actions. In this study, we compared the cytotoxicity of six frequently used LAs and will discuss the possible mechanism(s) underlying their toxicity...
  93. ncbi Benefit and risks of local anesthetics in infants and children
    Joel B Gunter
    Department of Anesthesia, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Paediatr Drugs 4:649-72. 2002
    ..b>Mepivacaine has been used for both plexus and epidural anesthesia in infants and children...
  94. ncbi From cocaine to ropivacaine: the history of local anesthetic drugs
    Y A Ruetsch
    University of Zurich, Department of Anesthesiology, Orthopedic University Clinic Balgrist, Switzerland
    Curr Top Med Chem 1:175-82. 2001
    ..were prepared between 1898 and 1972 including nirvaquine, procaine, chloroprocaine, cinchocaine, lidocaine, mepivacaine, prilocaine, efocaine, bupivacaine, etidocaine, and articaine...
  95. ncbi [Peribulbar anesthesia versus retrobulbar anesthesia with facial nerve block. Techniques, local anesthetics and additives, akinesia and sensory block, complications]
    V Hessemer
    Universitäts Augenklinik Giessen
    Klin Monbl Augenheilkd 204:75-89. 1994
    ..There is, however, an increasing tendency to use peribulbar anesthesia (PERI), which is claimed to provide the same degree of anesthesia and akinesia as RETRO while reducing many of the complications...
  96. ncbi Immunological modulation by lidocaine-epinephrine and prilocaine-felypressin on the functions related to natural immunity in neutrophils and macrophages
    Yasutaka Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Osaka 573 1121, Japan
    Curr Drug Targets Immune Endocr Metabol Disord 4:29-36. 2004
    ..the clinical setting, we have examined possible abilities of both local anesthetic alone including lidocaine, mepivacaine, procaine, prilocaine and tetracaine, and local anesthetics with blood vessel contraction drugs including ..
  97. ncbi Simultaneous determination of viloxazine, venlafaxine, imipramine, desipramine, sertraline, and amoxapine in whole blood: comparison of two extraction/cleanup procedures for capillary gas chromatography with nitrogen-phosphorus detection
    M A Martinez
    Department of Chemistry, National Institute of Toxicology, Ministry of Justice, Madrid, Spain
    J Anal Toxicol 26:296-302. 2002
    ..0 mL of whole blood extraction and injection into a capillary GC equipped with a nitrogen-phosphorus detector. Mepivacaine was used as the extraction standard (surrogate), and prazepam was used as the chromatographic standard...
  98. ncbi Fundamental properties of local anesthetics: half-maximal blocking concentrations for tonic block of Na+ and K+ channels in peripheral nerve
    M E Bräu
    Department of Anesthesiology and Intensive Care Medicine, Justus Liebig University, Giessen, Germany
    Anesth Analg 87:885-9. 1998
    ..7 microM, etidocaine 18 microM, bupivacaine 27 microM, procaine 60 microM, mepivacaine 149 microM, and lidocaine 204 microM...
  99. ncbi [The equipotency of ropivacaine, bupivacaine and etidocaine]
    W Wahedi
    Institut für Anaesthesiologie, Klinikum Minden
    Reg Anaesth 13:66-72. 1990
    Ropivacaine, congenerate to bupivacaine and mepivacaine has been widely studied in laboratory animals, but there have been few investigations of its efficacy in human epidural anesthesia and peripheral nerve blocks...
  100. ncbi [Oral analgesia versus posterior tibial nerve block for postoperative pain in ambulatory open hallux valgus surgery: a randomized clinical trial]
    C Ferrer Gómez
    Servicio de Anestesiologia y Reanimacion, Hospital Universitari Joan XXIII, Tarragona
    Rev Esp Anestesiol Reanim 53:220-5. 2006
    ..This trial assessed the safety and efficacy of a continuous posterior tibial nerve block in the ankle provided in the patient's home by elastomeric pump infusion of 0.375% ropivacaine after ambulatory hallux valgus surgery...
  101. ncbi [Transient neurologic symptoms after spinal anesthesia. A quantitative systematic overview (meta-analysis) of randomized controlled studies]
    L H Eberhart
    Klinik für Anästhesiologie und Intensivtherapie, Philipps Universitat Marburg, Baldingerstrasse 1, 35033 Marburg
    Anaesthesist 51:539-46. 2002
    ..The type and the preparation of the local anesthetic drug (baricity, concentration, additives or preservatives) are most often discussed as the underlying cause of TNS...

Research Grants4

  1. FETAL UPTAKE AND DISTRIBUTION OF LOCAL ANESTHETICS
    ROLAND KENNEDY; Fiscal Year: 1980
    ..Because local anesthetics possess varying physiochemical properties, we are studying lidocaine, mepivacaine, bupivacaine, etidocaine and prilocaine to relate the blood concentrations and uptake to these properties.
  2. Microbiology/Immunology of Periodontal Disease in T1DM
    Paul Moore; Fiscal Year: 2002
    ..An integrated multidisciplinary effort provides significant data collection capabilities essential for understanding the complex multifactorial etiology of periodontal disease in Type 1 diabetes. ..
  3. ORAL HEALTH OF OLDER TYPE 1 DIABETIC PATIENTS
    Paul Moore; Fiscal Year: 2003
    ..This overall plan will permit us to understand the etiology of these complications and to define specific subpopulations and risk factors appropriate for future prospective oral health prevention and intervention trials. ..
  4. PHARMACOLOGY OF CARDIAC SODIUM CHANNEL MODIFIERS
    Michael Sheets; Fiscal Year: 2008
    ..The results of these studies should improve our overall understanding of the molecular mechanisms of anti-arrhythmic drugs modification of cardiac Na channels. [unreadable] [unreadable]..