loperamide

Summary

Summary: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.

Top Publications

  1. ncbi Comparison of the peripheral and central effects of the opioid agonists loperamide and morphine in the formalin test in rats
    Harlan E Shannon
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Neuropharmacology 42:253-61. 2002
  2. ncbi Antidiarrhoeal activity of hot water extract of black tea (Camellia sinensis)
    S E Besra
    Division of Pharmacology and Experimental Therapeutics, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Calcutta 700032, India
    Phytother Res 17:380-4. 2003
  3. ncbi The effects of loperamide, or loperamide plus simethicone, on the distribution of gut water as assessed by MRI in a mannitol model of secretory diarrhoea
    E Placidi
    Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, UK
    Aliment Pharmacol Ther 36:64-73. 2012
  4. ncbi Control of irinotecan-induced diarrhea by octreotide after loperamide failure
    V Barbounis
    2nd Department of Medical Oncology, St Saves Hospital, Athens, Greece
    Support Care Cancer 9:258-60. 2001
  5. ncbi Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide
    S K Quinney
    Department of Pharmacy Practice, Purdue University, Indianapolis, IN 46202, USA
    J Pharmacol Exp Ther 313:1011-6. 2005
  6. ncbi Urinary bladder relaxation through activation of opioid μ-receptors induced by loperamide is increased in diabetic rats
    L M Lee
    Department of Urology, College of Medicine, Taipei Medical University Wan Fang Hospital, Wang Fang, Taipei City, Taiwan
    Exp Clin Endocrinol Diabetes 120:323-8. 2012
  7. ncbi Targeted nanoparticles that mimic immune cells in pain control inducing analgesic and anti-inflammatory actions: a potential novel treatment of acute and chronic pain condition
    Susan Hua
    University of Newcastle, Newcastle, Australia and The University of Queensland, Brisbane, Australia
    Pain Physician 16:E199-216. 2013
  8. pmc Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, 720 Rutland Avenue, Ross 350, Baltimore, MD 21205, USA
    Pain 138:318-29. 2008
  9. ncbi Targeting the central nervous system: in vivo experiments with peptide-derivatized nanoparticles loaded with Loperamide and Rhodamine-123
    G Tosi
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    J Control Release 122:1-9. 2007
  10. pmc P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide
    William C Kreisl
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Nucl Med 51:559-66. 2010

Detail Information

Publications230 found, 100 shown here

  1. ncbi Comparison of the peripheral and central effects of the opioid agonists loperamide and morphine in the formalin test in rats
    Harlan E Shannon
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Neuropharmacology 42:253-61. 2002
    The effects of the peripherally restricted opioid agonist loperamide were compared to those of morphine in the formalin test in rats...
  2. ncbi Antidiarrhoeal activity of hot water extract of black tea (Camellia sinensis)
    S E Besra
    Division of Pharmacology and Experimental Therapeutics, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Calcutta 700032, India
    Phytother Res 17:380-4. 2003
    ..Naloxone (0.5 mg/kg i.p.) significantly inhibited the antidiarrhoeal activity of the extract as well as loperamide, thus indicating a role of the opioid system in the antidiarrhoeal activity of the extract.
  3. ncbi The effects of loperamide, or loperamide plus simethicone, on the distribution of gut water as assessed by MRI in a mannitol model of secretory diarrhoea
    E Placidi
    Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, UK
    Aliment Pharmacol Ther 36:64-73. 2012
    b>Loperamide (LOP) is an anti-diarrhoeal agent which is thought to act largely by slowing transit with an uncertain effect on the fluid content of the small and large bowel in humans...
  4. ncbi Control of irinotecan-induced diarrhea by octreotide after loperamide failure
    V Barbounis
    2nd Department of Medical Oncology, St Saves Hospital, Athens, Greece
    Support Care Cancer 9:258-60. 2001
    ..Standard antidiarrheal treatment is based on high-dose loperamide, but this agent is associated with a significant failure rate...
  5. ncbi Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide
    S K Quinney
    Department of Pharmacy Practice, Purdue University, Indianapolis, IN 46202, USA
    J Pharmacol Exp Ther 313:1011-6. 2005
    ..b>Loperamide is a strong inhibitor of CES2, with a K(i) of 1.5 muM, but it only weakly inhibits CES1A1 (IC(50) = 0.44 mM)...
  6. ncbi Urinary bladder relaxation through activation of opioid μ-receptors induced by loperamide is increased in diabetic rats
    L M Lee
    Department of Urology, College of Medicine, Taipei Medical University Wan Fang Hospital, Wang Fang, Taipei City, Taiwan
    Exp Clin Endocrinol Diabetes 120:323-8. 2012
    ..Thus, we used loperamide to activate opioid μ-receptors for urinary bladder relaxation and compared the differences between normal and ..
  7. ncbi Targeted nanoparticles that mimic immune cells in pain control inducing analgesic and anti-inflammatory actions: a potential novel treatment of acute and chronic pain condition
    Susan Hua
    University of Newcastle, Newcastle, Australia and The University of Queensland, Brisbane, Australia
    Pain Physician 16:E199-216. 2013
    ....
  8. pmc Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, 720 Rutland Avenue, Ross 350, Baltimore, MD 21205, USA
    Pain 138:318-29. 2008
    ..Systemic loperamide hydrochloride (0.3-10 mg/kg, s.c...
  9. ncbi Targeting the central nervous system: in vivo experiments with peptide-derivatized nanoparticles loaded with Loperamide and Rhodamine-123
    G Tosi
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    J Control Release 122:1-9. 2007
    ..In this research, g-7 Np were loaded with Loperamide in order to assess their ability as drug carriers for CNS, and with Rhodamine-123, in order to qualitatively ..
  10. pmc P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide
    William C Kreisl
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Nucl Med 51:559-66. 2010
    ..P-gp almost completely blocks brain entry of the PET radiotracer (11)C-N-desmethyl-loperamide ((11)C-dLop)...
  11. ncbi Relative contribution of peripheral versus central opioid receptors to antinociception
    Dominika Labuz
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Brain Res 1160:30-8. 2007
    ..population to antinociception elicited by systemically administered centrally penetrating opioids, and by loperamide (a peripherally restricted opioid). Nociception (abdominal writhes) was induced by intraperitoneally (i.p...
  12. ncbi Characterization of two models of drug-induced constipation in mice and evaluation of mustard oil in these models
    Ryosuke Kojima
    Drug Discovery Research, Astellas Pharma Inc, Tsukuba, Ibaraki, Japan
    Pharmacology 84:227-33. 2009
    Although it is known that both clonidine and loperamide cause delayed colonic transit in mice, these models of drug-induced experimental constipation have not yet been fully characterized...
  13. ncbi Guidelines for adults on self-medication for the treatment of acute diarrhoea
    D Wingate
    St Bartholomew s and the Royal London School of Medicine and Dentistry, Gastrointestinal Science Research Unit, London, UK
    Aliment Pharmacol Ther 15:773-82. 2001
    ..There is no evidence that it prolongs the illness. Self-medication in otherwise healthy adults is safe. Oral loperamide is the treatment of choice...
  14. ncbi Lactic acid fermentation of germinated barley fiber and proliferative function of colonic epithelial cells in loperamide-induced rats
    Jeong Ryae Jeon
    Department of Food and Nutrition, Yeungnam University, Gyeongsan, Republic of Korea
    J Med Food 13:950-60. 2010
    ..The effect of GBFY on colonic epithelial proliferation was investigated through loperamide (LPM)-induced constipation in rats...
  15. pmc Laxative activities of Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae) leaf aqueous extract in rats
    Souleymane Méité
    Laboratoire de pharmacodynamie biochimique, UFR Biosciences, Université de Cocody Abidjan, 22 BP 582 Abidjan 22, Cote d Ivoire
    BMC Complement Altern Med 10:7. 2010
    ..The present study was carried out to investigate the laxative activity of Mareya micrantha in albino's Wistar rats...
  16. ncbi Administration of loperamide and addition of wheat bran to the diets of weaner pigs decrease the incidence of diarrhoea and enhance their gut maturation
    Francesc Molist Gasa
    Grup de Nutrició, Maneig i Benestar Animal, Departament de Ciencia Animal i dels Aliments, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Spain
    Br J Nutr 103:879-85. 2010
    ..For these experiments, wheat bran (WB) was used as fibre source and loperamide as a drug (LOP) to increase the digesta transit time...
  17. ncbi Tariquidar, a selective P-glycoprotein inhibitor, does not potentiate loperamide's opioid brain effects in humans despite full inhibition of lymphocyte P-glycoprotein
    Daniel Kurnik
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Anesthesiology 109:1092-9. 2008
    b>Loperamide, a potent opioid, has been used as an in vivo probe to assess P-glycoprotein activity at the blood-brain barrier, because P-glycoprotein inhibition allows loperamide to cross the blood-brain barrier and exert its central opioid ..
  18. ncbi No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects
    Christiane Pauli-Magnus
    Department of Biopharmaceutical Sciences, University of California, San Francisco, CA 94143 0446, USA
    Clin Pharmacol Ther 74:487-98. 2003
    ..The aim of this study was to investigate the effect of this polymorphism on disposition and brain entry of the P-glycoprotein substrate loperamide.
  19. pmc P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys
    Jeih San Liow
    Molecular Imaging Branch, PET Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 2035, USA
    J Nucl Med 50:108-15. 2009
    11C-Loperamide is an avid substrate for P-glycoprotein (P-gp), but it is rapidly metabolized to 11C-N-desmethyl-loperamide (11C-dLop), which is also a substrate for P-gp and thereby contaminates the radioactive signal in the brain...
  20. ncbi Efficacy of methylcellulose and loperamide in managing fecal incontinence
    Eddie H M Sze
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Urogynecology and Reconstructive Pelvic Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Acta Obstet Gynecol Scand 88:766-71. 2009
    To evaluate the efficacy of methylcellulose (Citrucel) and loperamide (Imodium) in managing fecal incontinence by comparing cure rates with expectant management.
  21. ncbi Binding site of loperamide: automated docking of loperamide in human mu- and delta-opioid receptors
    Antonio Mazzella di Bosco
    Dipartimento di Chimica Farmaceutica e Tossicologica, Universita di Napoli Federico II, via D Montesano, 49 80131 Napoli, Italy
    Chem Biol Drug Des 71:328-35. 2008
    b>Loperamide is a piperidine analogue, acting as agonist on peripheral opioid receptors, exhibiting affinity and selectivity for the cloned mu human opioid receptor compared with the delta human opioid receptor...
  22. ncbi Development of tolerance to the inhibitory effect of loperamide on gastrointestinal transit in mice
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima Aoba ku, Sendai 981 8558, Japan
    Eur J Pharm Sci 20:357-63. 2003
    The inhibitory effect of repetitiously administered loperamide, a peripheral mu-opioid receptor agonist and well-recognized antidiarrheal agent, on mouse gastrointestinal transit was compared with that of morphine in order to examine the ..
  23. pmc Liquid chromatography-tandem mass spectrometry for analysis of intestinal permeability of loperamide in physiological buffer
    Miriam S Rubelt
    Department of Anesthesiology, Charite, Campus Benjamin Franklin, Berlin, Germany
    PLoS ONE 7:e48502. 2012
    ..we developed and validated a fast, sensitive and selective method based on LC-MS/MS for the determination of loperamide in HEPES-buffered Ringer's solution. Chromatographic separation was achieved with an Atlantis dC18 column, 2...
  24. ncbi Loperamide-induced rat prostate relaxation through activation of peripheral µ-opioid receptors
    Juei Tang Cheng
    Department of Medical Research, Chi Mei Medical Center, Yong Kang City, Tainan, Taiwan
    Neurourol Urodyn 30:468-71. 2011
    The effect of µ-opioid receptor (MOR) agonist, loperamide on prostate relaxation and the role of potassium channel in this action were studied in isolated Wistar rat prostate.
  25. ncbi Effect of metoclopramide, bethanechol, and loperamide on gastric residence time, gastric emptying, and mouth-to-cecum transit time
    M G Kirby
    University of North Carolina School of Pharmacy, Chapel Hill
    Pharmacotherapy 9:226-31. 1989
    The effects of metoclopramide, bethanechol, and loperamide on the gastric residence time (GRT), gastric emptying (GE), and mouth-to-cecum transit time (MCTT) of a solution were investigated in three separate studies of five healthy male ..
  26. ncbi Effects of surface modification of PLGA-PEG-PLGA nanoparticles on loperamide delivery efficiency across the blood-brain barrier
    Yung Chu Chen
    Tissue Regeneration Product Technology Division, Industrial Technology Research Institute, Hsinchu 31040, Taiwan
    J Biomater Appl 27:909-22. 2013
    ..The nanoparticle consisting of loperamide and poly(lactide-co-glycolide)-poly(ethylene glycol)-poly(lactide-co-glycolide) (PLGA-PEG-PLGA) triblock ..
  27. ncbi Optimization of the preparation of loperamide-loaded poly (L-lactide) nanoparticles by high pressure emulsification-solvent evaporation
    M Ueda
    , , Frankfurt am Main, Germany
    J Microencapsul 14:593-605. 1997
    The entrapment of loperamide hydrochloride (LPM) in biodegradable polymeric drug carriers such as nanoparticles might enable its passage across the blood-brain barrier...
  28. ncbi Influence of the preparation methods on the drug release behaviour of loperamide-loaded nanoparticles
    M Ueda
    , , Frankfurt Main, Germany
    J Microencapsul 15:361-72. 1998
    Polylactide (PLA) or poly(lactide-coglycolide) (PLGA) nanoparticles containing loperamide (LPM) were prepared by an incorporation or adsorption method with the objective of developing nanoparticles with a rapid drug release...
  29. ncbi Phase behaviour analysis of solid dispersions of loperamide and two structurally related compounds with the polymers PVP-K30 and PVP-VA64
    Ilse Weuts
    Laboratorium voor Farmacotechnologie en Biofarmacie, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Eur J Pharm Sci 22:375-85. 2004
    ..of the present study was to investigate the influence of the structure of a poorly water soluble model drug (loperamide) on the phase behaviour in solid dispersions with PVP-K30...
  30. ncbi Effects of Ficus carica paste on loperamide-induced constipation in rats
    Hak Yong Lee
    BIOSOLOMON, Inc, Jeonju, Republic of Korea
    Food Chem Toxicol 50:895-902. 2012
    Constipation is one of the most common gastrointestinal complaints worldwide. This study examined the effects of fig (Ficus carica L.) paste for the treatment of loperamide-induced constipation in a rat model.
  31. ncbi Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes
    Kyoung Ah Kim
    Department of Pharmacology, Gil Medical Center, Gachon Medical School, 1198 Kuwol dong, 405 760, Incheon, Namdong gu, Korea
    Eur J Clin Pharmacol 60:575-81. 2004
    The purpose of the present study was to elucidate the cytochrome P450 (P450) isoform(s) involved in the metabolism of loperamide (LOP) to N-demethylated LOP (DLOP) in human liver microsomes.
  32. ncbi Antinociceptive effect of intrathecal loperamide: role of mu-opioid receptor and calcium channels
    Rakesh Kumar
    Department of Anatomy, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Eur J Pharmacol 696:77-82. 2012
    ..Peripherally administered loperamide lacks effect on the central nervous system as it is a substrate for the permeability glycoprotein (P-gp) efflux ..
  33. pmc Effect of colic vein ligature in rats with loperamide-induced constipation
    Flavia Neri
    Department of General Surgery and Transplantation, S Orsola Malpighi Hospital, University of Bologna, 40126 Bologna, Italy
    J Biomed Biotechnol 2012:896162. 2012
    ..Medical treatment in chronic constipation is not always successful. Surgery is indicated in unresponsive selected severe cases. This study presents the distal venous colic ligation in rat as a novel surgical approach...
  34. ncbi Study of the physicochemical properties and stability of solid dispersions of loperamide and PEG6000 prepared by spray drying
    Ilse Weuts
    Laboratorium voor Farmacotechnologie en Biofarmacie, University of Leuven, Leuven, Belgium
    Eur J Pharm Biopharm 59:119-26. 2005
    Solid dispersions of PEG6000 and loperamide-a poorly water-soluble agent-were prepared by spray drying. Their physicochemical properties were evaluated immediately after preparation...
  35. pmc Fitting the elementary rate constants of the P-gp transporter network in the hMDR1-MDCK confluent cell monolayer using a particle swarm algorithm
    Deep Agnani
    Department of Biology, Drexel University, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e25086. 2011
    ..Transport of a range of concentrations of amprenavir, loperamide, quinidine and digoxin across the confluent monolayer of cells was measured in both directions, apical to ..
  36. ncbi Novel pharmacological activity of loperamide and CP-339,818 on human HCN channels characterized with an automated electrophysiology assay
    Yan T Lee
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, United States
    Eur J Pharmacol 581:97-104. 2008
    ..Two blockers known for their activity at opioid/Ca(2+) channels and K(+) channels, loperamide and CP-339,818 (respectively), are described to block HCN1 more potently than HCN4...
  37. ncbi Comparison of racecadotril and loperamide in adults with acute diarrhoea
    J M Vetel
    Centre Hospitalier, Le Mans, Paris, France
    Aliment Pharmacol Ther 13:21-6. 1999
    ..was carried out to compare the efficacy, tolerability, and safety of racecadotril (100 mg three times daily) and loperamide (2 mg after each diarrhoeic stool) in 157 adults with acute diarrhoea...
  38. pmc Loperamide, an FDA-approved antidiarrhea drug, effectively reverses the resistance of multidrug resistant MCF-7/MDR1 human breast cancer cells to doxorubicin-induced cytotoxicity
    Yanfei Zhou
    Department of Oral Pathology, Howard University, Washington, DC, USA
    Cancer Invest 30:119-25. 2012
    b>Loperamide is an FDA-approved antidiarrhea drug which acts on the μ-opioid receptors in the mesenteric plexus of large intestine and exhibits limited side effects...
  39. pmc N-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier
    Pavitra Kannan
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Drug Metab Dispos 38:917-22. 2010
    11)C]N-desmethyl-Loperamide ([(11)C]dLop) is used in positron emission tomography (PET) to measure the in vivo activity of efflux transporters that block the passage of drugs across the blood-brain barrier...
  40. ncbi The role of loperamide in gastrointestinal disorders
    Stephen B Hanauer
    Section of Gastroenterology, Hepatology, and Nutrition, University of Chicago, Chicago, Illinois, USA
    Rev Gastroenterol Disord 8:15-20. 2008
    b>Loperamide is an effective therapy for a variety of diarrheal syndromes, including acute, nonspecific (infectious) diarrhea; traveler's diarrhea; and chemotherapy-related and protease inhibitor?associated diarrhea...
  41. ncbi Analgesic action of loperamide, an opioid agonist, and its blocking action on voltage-dependent Ca2+ channels
    Kunie Hagiwara
    Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, 2 1 Seiryomachi Aobaku, Sendai 980 8575, Japan
    Neurosci Res 46:493-7. 2003
    We investigated the relationship between the antinociceptive effect of the opiate agonist loperamide at the spinal level and its inhibitory effect on calcium influx...
  42. ncbi Effects of loperamide on mechanical allodynia induced by herpes simplex virus type-1 in mice
    Atsushi Sasaki
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Pharmacol Sci 104:218-24. 2007
    In the present study, we investigated whether the peripherally acting micro-opioid receptor agonist loperamide would inhibit allodynia in the non-inflamed dermatome of mice with herpetic pain. Subcutaneous (s.c...
  43. pmc Loperamide therapy for acute diarrhea in children: systematic review and meta-analysis
    Su Ting T Li
    Department of Pediatrics, University of California Davis, Sacramento, California, United States of America
    PLoS Med 4:e98. 2007
    b>Loperamide is widely used in adults for acute diarrhea. However, its use in children has been discouraged by the World Health Organization and the American Academy of Pediatrics owing to concerns over safety and efficacy in young children.
  44. pmc Antihyperalgesic effects of loperamide in a model of rat neuropathic pain are mediated by peripheral delta-opioid receptors
    Katsumi Shinoda
    Pharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, 1188 Shimotogari, Nagaizumi cho, Sunto gun, Shizuoka ken 411 8731, Japan
    Neurosci Lett 411:143-6. 2007
    The possible antihyperalgesic and antiallodynic activity of loperamide, an opioid agonist which does not readily penetrate the blood-brain barrier, were examined in the spinal nerve ligation model of experimental neuropathic pain...
  45. ncbi Potential roles of P-gp and calcium channels in loperamide and diphenoxylate transport
    Andrew Crowe
    School of Pharmacy, Curtin University of Technology, GPO Box U1987, Perth, Western Australia, 6845, Australia
    Toxicol Appl Pharmacol 193:127-37. 2003
    ..Cellular uptake and efflux and transcellular transport were all determined using Caco-2 cells after exposure to loperamide or diphenoxylate, with or without a range of efflux inhibitors...
  46. ncbi The influence of mass of [11C]-laniquidar and [11C]-N-desmethyl-loperamide on P-glycoprotein blockage at the blood-brain barrier
    Lieselotte Moerman
    Laboratory of Radiopharmacy, Ghent University, B 9000 Ghent, Belgium
    Nucl Med Biol 39:121-5. 2012
    ..Thereby, this study investigated the influence of mass dose of laniquidar, desmethyl-loperamide and loperamide on the P-glycoprotein-mediated brain uptake of, respectively, [(11)C]-laniquidar and [(11)C]-N-..
  47. ncbi Determination of loperamide in mdr1a/1b knock-out mouse brain tissue using matrix-assisted laser desorption/ionization mass spectrometry and comparison with quantitative electrospray-triple quadrupole mass spectrometry analysis
    Young G Shin
    Department of Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA 94080, USA
    Arch Pharm Res 34:1983-8. 2011
    ..In this study, the quantitative determination of loperamide, an antidiarrheal agent and a P-glycoprotein substrate, in mdr1a/1b (-/-) mouse brain tissue sections using ..
  48. pmc Competitive substrates for P-glycoprotein and organic anion protein transporters differentially reduce blood organ transport of fentanyl and loperamide: pharmacokinetics and pharmacodynamics in Sprague-Dawley rats
    Iman A Elkiweri
    College of Nursing, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia
    Anesth Analg 108:149-59. 2009
    ..We hypothesized that transport proteins P-gp and Oatp mediate opioid uptake in a drug and organ-specific manner, making them excellent potential targets for therapeutic intervention...
  49. ncbi A multinational comparison of racecadotril and loperamide in the treatment of acute watery diarrhoea in adults
    D Prado
    Hospital Centro Médico, Guatemala City, Guatemala
    Scand J Gastroenterol 37:656-61. 2002
    ..The aim of this study was to compare the efficacy, safety and tolerability of racecadotril with those of loperamide by assessing their effects on the resolution of the signs and symptoms of diarrhoea in patients in developing ..
  50. ncbi Racecadotril versus loperamide: antidiarrheal research revisited
    S Huighebaert
    Consultant Pharmaceutical Sciences, La Hulpe, Belgium
    Dig Dis Sci 48:239-50. 2003
    ..inhibitor, presented as a purely antisecretory agent with advantages over the opiate-receptor agonist loperamide in the treatment of diarrhea. A critical review of the literature and the models used was performed...
  51. ncbi Use of loperamide as a phenotypic probe of mdr1a status in CF-1 mice
    J Cory Kalvass
    Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Pharm Res 21:1867-70. 2004
    ..Mice lacking the mdr1a gene represent an important research tool to study the potential effects of P-gp on CNS substrate disposition...
  52. ncbi Effects of fasting on evaluation of gastrointestinal transit with charcoal meal
    S W Mittelstadt
    Drug Safety Assessment, Procter and Gamble Pharmaceuticals, Miami Valley Innovation Center, Cincinnati, OH 45252, USA
    J Pharmacol Toxicol Methods 52:154-8. 2005
    ..The purpose of this study was to investigate the effects of food on the pharmacological effects on gastrointestinal transit...
  53. ncbi Loperamide-induced enhancement of moxidectin availability in cattle
    A Lifschitz
    Laboratorio de Farmacologia, Departamento de Fisiopatologia, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro, Tandil, Argentina
    J Vet Pharmacol Ther 25:111-20. 2002
    ..b>Loperamide (LPM) is an opioid derivative, whose main pharmacological action is to abolish intestinal propulsive peristaltic ..
  54. ncbi Local loperamide inhibits thermal hyperalgesia but not mechanical allodynia induced by intratibial inoculation of melanoma cells in mice
    Verdad Curto-Reyes
    Laboratorio de Farmacologia, Facultad de Medicina, Instituto Universitario de Oncologia del Principado de Asturias IUOPA, Universidad de Oviedo, C Julian Claveria 6, 33006 Oviedo, Asturias, Spain
    Cell Mol Neurobiol 28:981-90. 2008
    ..Intraplantar administration of loperamide (15 microg, 30 min before) inhibited thermal hyperalgesia, but did not modify the intense mechanical allodynia...
  55. ncbi Agarwood induced laxative effects via acetylcholine receptors on loperamide-induced constipation in mice
    Mamoru Kakino
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu, Japan
    Biosci Biotechnol Biochem 74:1550-5. 2010
    ..of EEAs (mangiferin, and genkwanin-5-O-primeveroside), and senna increased the frequency and weight of stools in loperamide-induced constipation model mice...
  56. ncbi pH dependent uptake of loperamide across the gastrointestinal tract: an in vitro study
    Andrew Crowe
    School of Pharmacy, Curtin University of Technology, Perth, Western Australia
    Drug Dev Ind Pharm 30:449-59. 2004
    b>Loperamide is a peripherally acting antidiarrheal opioid with some affinity for P-glycoprotein (P-gp)...
  57. ncbi Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity
    D L Dehaven-Hudkins
    Adolor Corporation, Malvern, Pennsylvania, USA
    J Pharmacol Exp Ther 289:494-502. 1999
    The antihyperalgesic properties of the opiate antidiarrheal agent loperamide (ADL 2-1294) were investigated in a variety of inflammatory pain models in rodents...
  58. ncbi Comparison of racecadotril and loperamide in children with acute diarrhoea
    D Turck
    Hopital Jeanne de Flandre, Lille, Paris, France
    Aliment Pharmacol Ther 13:27-32. 1999
    ..double-placebo study was carried out to compare the efficacy, tolerability, and safety of racecadotril and loperamide in children aged 2 to 10 years who were suffering from acute diarrhoea. Patients received racecadotril (1...
  59. ncbi Loperamide: a pharmacological review
    Daniel E Baker
    College of Pharmacy, Washington State University Spokane, Spokane, Washington, USA
    Rev Gastroenterol Disord 7:S11-8. 2007
    b>Loperamide is an antidiarrheal medication approved for the control of diarrhea symptoms and is available without a prescription...
  60. ncbi Direct inhibition of Ih by analgesic loperamide in rat DRG neurons
    Dmitry V Vasilyev
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    J Neurophysiol 97:3713-21. 2007
    ..We found that the known analgesic loperamide inhibited I(h) channels in rat DRG neurons...
  61. ncbi Toxicological evaluation of aqueous extract of Aloe ferox Mill. in loperamide-induced constipated rats
    O A Wintola
    Department of Botany, University of Fort Hare, Alice, South Africa
    Hum Exp Toxicol 30:425-31. 2011
    ..mg/kg body weight for 7 days on the haematological parameters as well as liver and kidney function indices in loperamide-induced constipated rats. The extract did not cause any significant (p > 0...
  62. pmc Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein
    Nicholas Seneca
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    J Nucl Med 50:807-13. 2009
    ..At the blood-brain barrier, P-gp blocks the entry of both loperamide and its metabolite, N-desmethyl-loperamide (N-dLop), and thereby prevents central opiate effects...
  63. ncbi Activation of opioid mu-receptors by loperamide to improve interleukin-6-induced inhibition of insulin signals in myoblast C2C12 cells
    T F Tzeng
    Department of Internal Medicine, Pao Chien Hospital, Ping Tung City, Taiwan, Republic of China
    Diabetologia 48:1386-92. 2005
    ..This study investigated the role of opioid mu-receptor activation in the improvement of insulin resistance...
  64. ncbi The steady-state Michaelis-Menten analysis of P-glycoprotein mediated transport through a confluent cell monolayer cannot predict the correct Michaelis constant Km
    Joe Bentz
    Department of Bioscience and Biotechnology, Drexel University, Philadelphia, Pennsylvania, 19104, USA
    Pharm Res 22:1667-77. 2005
    ....
  65. ncbi Kinetic identification of membrane transporters that assist P-glycoprotein-mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII-hMDR1 cells
    Poulomi Acharya
    Department of Bioscience and Biotechnology, Drexel University, 32nd and Chestnut Sts, Philadelphia, PA 19104, USA
    Drug Metab Dispos 36:452-60. 2008
    ..MDCKII-hMDR1 cells, we have determined the elementary rate constants for the P-gp efflux of amprenavir, digoxin, loperamide, and quinidine. For amprenavir and quinidine, transport was fitted with just P-gp and passive permeability...
  66. pmc The effect of Aloe ferox Mill. in the treatment of loperamide-induced constipation in Wistar rats
    Olubunmi A Wintola
    Department of Botany, University of Fort Hare, Alice 5700, South Africa
    BMC Gastroenterol 10:95. 2010
    ..In this study, the efficacy of aqueous leaf extract of Aloe ferox Mill. was studied against loperamide-induced constipation in Wistar rats.
  67. pmc Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function
    Neva Lazarova
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
    J Med Chem 51:6034-43. 2008
    11)C]Loperamide has been proposed for imaging P-glycoprotein (P-gp) function with positron emission tomography (PET), but its metabolism to [N-methyl-(11)C] N-desmethyl-loperamide ([(11)C]dLop; [(11)C]3) precludes quantification...
  68. ncbi Loperamide cause of prolonged urinary retention after acute gastroenteritis
    B Focarelli
    Department of Paediatric Science, Urodynamic Laboratory, Catholic University Medical School, Rome, Italy
    Eur Rev Med Pharmacol Sci 11:65-7. 2007
    Urinary retention is uncommon in children and only one case has been described in literature with loperamide treatment...
  69. ncbi Influence of senna, fibre, and fibre + senna on colonic transit in loperamide-induced constipation
    K Ewe
    I Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, FRG
    Pharmacology 47:242-8. 1993
    ..Twelve persons taking a normal diet received loperamide in a dose sufficient to double the individual transit time...
  70. ncbi [Ileus after the use of loperamide in a child with acute diarrhea]
    J Dudink
    Leids Universitair Medisch Centrum, afd Kindergeneeskunde, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 147:670-2. 2003
    ..girl was diagnosed as having acute gastroenteritis with severe diarrhoea, for which she was prescribed a loperamide solution. Following this she developed paralytic ileus...
  71. ncbi Signals in the activation of opioid mu-receptors by loperamide to enhance glucose uptake into cultured C2C12 cells
    I M Liu
    The Department of Pharmacy, Tajen Institute of Technology, Yen Pou, Ping Tung Shien, Taiwan 90701, ROC
    Horm Metab Res 36:210-4. 2004
    In an attempt to understand the signal pathways of opioid mu-receptors for glucose metabolism, we used loperamide to investigate the glucose uptake into the myoblast C2C12 cells...
  72. ncbi Loperamide increases glucose ultilization in streptozotocin-induced diabetic rats
    T F Tzeng
    Department of Internal Medicine, Pao Chien Hospital, Ping Tung City, Taiwan
    Clin Exp Pharmacol Physiol 30:734-8. 2003
    1. Loperamide has an ability to lower the plasma glucose concentration in streptozotocin (STZ)-induced diabetic rats...
  73. ncbi Analgesic effects of morphine and loperamide in the rat formalin test: interactions with NMDA receptor antagonists
    Natalja Sevostianova
    Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, 60318 Frankfurt am Main, Germany
    Eur J Pharmacol 525:83-90. 2005
    To reveal peripheral components of opiate analgesia, effects of loperamide, opioid agonist which does not penetrate the blood-brain barrier, were examined in formalin and acute thermal pain tests in comparison with morphine...
  74. ncbi Treatment of travelers' diarrhea: randomized trial comparing rifaximin, rifaximin plus loperamide, and loperamide alone
    Herbert L DuPont
    Center for Infectious Diseases, University of Texas School of Public Health, Houston, Texas, USA
    Clin Gastroenterol Hepatol 5:451-6. 2007
    ..This study evaluated the efficacy and safety of rifaximin-loperamide in the treatment of travelers' diarrhea.
  75. ncbi Fibre supplementation in addition to loperamide for faecal incontinence in adults: a randomized trial
    M Lauti
    Department of Surgery, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Colorectal Dis 10:553-62. 2008
    ..Clinician opinion varies as to which initial approach is best. This study compared these treatments in routine clinical practice...
  76. pmc Spinal antinociceptive action of loperamide is mediated by opioid receptors in the formalin test in rats
    Subrata Basu Ray
    Department of Anesthesiology, University of California San Diego, La Jolla, CA 92093 0818, USA
    Neurosci Lett 448:260-2. 2008
    ..Being hydrophilic in nature, morphine also spreads rostrally which leads to respiratory depression. Loperamide has been reported to produce antinociception after both intracisternal and intrathecal administration...
  77. ncbi Analgesic effects of loperamide in bone cancer pain in mice
    Luis Menéndez
    Laboratorio de Farmacologia, Instituto Universitario de Oncologia del Principado de Asturias IUOPA, Facultad de Medicina, Universidad de Oviedo, C Julian Claveria 6, 33006 Oviedo, Asturias, Spain
    Pharmacol Biochem Behav 81:114-21. 2005
    ..Here, we initially describe that this osteosarcoma induces mechanical as well as thermal hyperalgesia. Loperamide, an opioid agonist unable to cross the blood-brain barrier, inhibits both thermal and mechanical hyperalgesia ..
  78. ncbi Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein
    Christoph Wandel
    Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee, USA
    Anesthesiology 96:913-20. 2002
    ..cassette superfamily, is a major determinant of the pharmacokinetics and pharmacodynamics of the opioid loperamide, a well-recognized antidiarrheal agent...
  79. ncbi P-Glycoprotein (P-gp) expressed in a confluent monolayer of hMDR1-MDCKII cells has more than one efflux pathway with cooperative binding sites
    Poulomi Acharya
    Department of Bioscience and Biotechnology, Drexel University, Philadelphia, Pennsylvania 19104, USA
    Biochemistry 45:15505-19. 2006
    ..e., the inhibitor became effective. These data and their analysis show that the binding of these substrates must be cooperative, either positive or negative...
  80. ncbi Antiallodynic effects of loperamide and fentanyl against topical capsaicin-induced allodynia in unanesthetized primates
    Eduardo R Butelman
    The Rockefeller University, Box 171, 1230 York Ave, New York, NY 10021, USA
    J Pharmacol Exp Ther 311:155-63. 2004
    ..g., on primary afferent neurons). These studies examined the ability of loperamide (0.1-1 mg/kg s.c...
  81. ncbi Loperamide toxicity in a collie with the MDR1 mutation associated with ivermectin sensitivity
    Laura L Sartor
    Department of Medical Sciences, College of Veterinary Medicine, University of Wisconsin, Madison, WI, USA
    J Vet Intern Med 18:117-8. 2004
  82. ncbi Effects of racecadotril and loperamide on bacterial proliferation and on the central nervous system of the newborn gnotobiotic piglet
    Y Duval-Iflah
    Institut National de la Recherche Agronomique, Unité d Ecologie et de Physiologie du Système Digestif, Centre de Recherche de Jouy, Jouy en Josas, France
    Aliment Pharmacol Ther 13:9-14. 1999
    ..of two drugs, an enkephalinase inhibitor (the antisecretory agent, racecadotril) and a mu-receptor agonist (loperamide), on intestinal growth of a bacterial nonpathogenic strain (Escherichia coli E 404) and on the central nervous ..
  83. ncbi Sulfated polysaccharides, but not cellulose, increase colonic mucus in rats with loperamide-induced constipation
    A Shimotoyodome
    Biological Science Laboratories, Kao Corporation, Haga-gun, Tochigi, Japan
    Dig Dis Sci 46:1482-9. 2001
    ..the fecal excretion, epithelial mucin production, thickness of the mucous layer, and amount of luminal mucus in loperamide-administered rats. Sodium alginate, 5 mg/day, thickened the mucus layer at the fecal surface...
  84. ncbi A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults
    Hwang Huei Wang
    Division of Gastroenterology, Department of Internal Medicine, China Medical University Hospital, 2 Yuh Der Road, Taichung, Taiwan, China
    World J Gastroenterol 11:1540-3. 2005
    ..b>Loperamide is an effective anti-diarrheal agent, but it usually induces constipation...
  85. ncbi Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes
    Luca Gallelli
    School of Medicine and Surgery, Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Mater Domini University Hospital, Catanzaro, Italy
    Eur J Clin Pharmacol 66:137-44. 2010
    Our aim was to compare the efficacy and tolerability of loperamide and racecadotril in elderly patients with acute diarrhea.
  86. ncbi Loperamide inhibits tachykinin NK3-receptor-triggered serotonin release without affecting NK2-receptor-triggered serotonin release from guinea pig colonic mucosa
    Shu Ichi Kojima
    Department of Pharmacology, Dokkyo University School of Medicine, Tochigi, Japan
    J Pharmacol Sci 98:175-80. 2005
    The effect of loperamide on tachykinin NK(2)- and NK(3)-receptor-mediated 5-HT outflow from guinea pig colonic mucosa was investigated in vitro...
  87. pmc The elementary mass action rate constants of P-gp transport for a confluent monolayer of MDCKII-hMDR1 cells
    Thuy Thanh Tran
    Department of Bioscience and Biotechnology, Drexel University, Philadelphia, Pennsylvania 19104, USA
    Biophys J 88:715-38. 2005
    ..For three P-gp substrates (amprenavir, loperamide, and quinidine), we have successfully fitted the elementary rate constants, i.e...
  88. ncbi Substantial activity of budesonide in patients with irinotecan (CPT-11) and 5-fluorouracil induced diarrhea and failure of loperamide treatment
    B H Lenfers
    Department of Medicine Gastroenterology Medical Oncology Endocrinology, Staedtische Kliniken Dortmund, Germany
    Ann Oncol 10:1251-3. 1999
    ..Standard therapy consists of high-dose loperamide, but is associated with frequent failure. Other therapeutic regimens are still experimental...
  89. ncbi Randomized, double-blind, placebo-controlled clinical trial of loperamide plus simethicone versus loperamide alone and simethicone alone in the treatment of acute diarrhea with gas-related abdominal discomfort
    Stephen B Hanauer
    Section of Gastroenterology and Nutrition, University of Chicago, Chicago, IL 60637, USA
    Curr Med Res Opin 23:1033-43. 2007
    To compare efficacy and tolerability of a loperamide/simethicone (LOP/SIM) combination product with that of loperamide (LOP) alone, simethicone (SIM) alone, and placebo (PBO) for acute nonspecific diarrhea with gas-related abdominal ..
  90. ncbi Traveler's diarrhea
    N N Ramzan
    Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Medical School, Scottsdale, Arizona, USA
    Gastroenterol Clin North Am 30:665-78, viii. 2001
    ..Treatment and prevention of this common problem is described in some detail. Finally, a practical and cost-effective approach to evaluating and treating a returning traveler is presented...
  91. ncbi Lethal gastroenteritis associated with clozapine and loperamide
    Markku Eronen
    Am J Psychiatry 160:2242-3. 2003
  92. pmc Prevention and self-treatment of traveler's diarrhea
    David J Diemert
    Human Hookworm Vaccine Initiative, Sabin Vaccine Institute, 1889 F St NW, Suite 200S, Washington, DC 20006, USA
    Clin Microbiol Rev 19:583-94. 2006
    ..In the future, vaccines-several of which are in the advanced stages of clinical testing-may be added to the list of prophylactic measures...
  93. pmc Use of probiotics for prevention of radiation-induced diarrhea
    P Delia
    Institute of Radiology, Oncologic Radiotherapy Unit, Azienda Ospedaliera Universitaria, Messina, Italy
    World J Gastroenterol 13:912-5. 2007
    ..To investigate the efficacy of a high-potency probiotic preparation on prevention of radiation-induced diarrhea in cancer patients...
  94. ncbi [Drug treatment of irritable bowel syndrome: an unmet need]
    Fermin Mearin
    Instituto de Trastornos Funcionales y Motores Digestivos, Servicio de Aparato Digestivo, Centro Medico Teknon, Barcelona, Espana
    Gastroenterol Hepatol 30:130-7. 2007
  95. ncbi Irritable bowel syndrome
    Howard R Mertz
    Department of Medicine, Division of Gastroenterology, Vanderbilt University, Nashville, USA
    N Engl J Med 349:2136-46. 2003
  96. ncbi Antidiarrhoeal activity of seed extract of Albizzia lebbeck Benth
    S E Besra
    Division of Pharmacology and Experimental Therapeutics, Indian Institute of Chemical Biology, Calcutta 700 032, India
    Phytother Res 16:529-33. 2002
    ..The extract (2.5-5 mg/kg i.p.) potentiated the antidiarrhoeal activity of loperamide (1 mg/kg i.p.). Nalaxone (0.5 mg/kg i.p...
  97. pmc Limited effects of beta-endorphin compared to loperamide or fentanyl in a neuroendocrine biomarker assay in non-human primates
    Eduardo R Butelman
    Laboratory on the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Psychoneuroendocrinology 33:292-304. 2008
    ..32 mg/kg; i.v.) in gonadally intact male rhesus monkeys (n=4) to that of the peripherally selective mu-agonist loperamide (0.01-0.32 mg/kg; i.v.) and the centrally penetrating mu-agonist fentanyl (0.0056-0.018 mg/kg; i.v.)...
  98. ncbi Treatment of diarrhea in patients with inflammatory bowel disease: concepts and cautions
    Shamita B Shah
    Section of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Rev Gastroenterol Disord 7:S3-10. 2007
    ..Other medications, including loperamide, diphenoxylate, codeine sulfate, and tinctures of opium, slow motility and increase the absorption of fluids and ..
  99. ncbi Inhibitory effects of ramosetron, a potent and selective 5-HT3-receptor antagonist, on conditioned fear stress-induced abnormal defecation and normal defecation in rats: comparative studies with antidiarrheal and spasmolytic agents
    Takuya Hirata
    Applied Pharmacology Research Laboratories, Drug Discovery Research, Astellas Pharma, Inc, Tsukuba, Ibaraki, Japan
    J Pharmacol Sci 106:264-70. 2008
    ..defecation and normal (non-stressed) defecation in rats and compared ramosetron with the antidiarrheal agent loperamide and the spasmolytic agents trimebutine and tiquizium...
  100. ncbi Effects of serotonin 5-HT(3) receptor antagonists on CRF-induced abnormal colonic water transport and defecation in rats
    Takuya Hirata
    Applied Pharmacology Research Laboratories, Drug Discovery Research, Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    Eur J Pharmacol 587:281-4. 2008
    ..of 5-HT(3) receptor antagonists including ramosetron, alosetron, and cilansetron, and the antidiarrheal agent loperamide, in this model...
  101. ncbi Efficacy of prophylactic anti-diarrhoeal treatment in patients receiving Campto for advanced colorectal cancer
    J Duffour
    Hopital La Timone, 264 rue St Pierre, Marseille, France
    Anticancer Res 22:3727-31. 2002
    ..In the case of severe diarrhoea, preventive treatment was replaced by loperamide(12 mg/d) and diosmectite (9 g/d). Grade 3 delayed diarrhoea occurred in 18% of patients (90% CI: [9.5-28...

Research Grants17

  1. Injury-Induced Pain: Chemical Modulation of Nociceptors
    Srinivasa N Raja; Fiscal Year: 2013
    ..Using the L5 spinal nerve ligation model in rodents, we found that loperamide, a peripherally acting opioid, alleviates behavioral signs of NP...
  2. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  3. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2008
    ..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
  4. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  5. Canine model for assessing CNS access P-gp substrates
    KATRINA MEALEY; Fiscal Year: 2005
    ....
  6. NABTC CENTRAL OPERATION GRANT (UCSF PROJECT LEADER)
    Michael Prados; Fiscal Year: 2008
    ..The NABTC will treat patients using novel therapeutic agents with the ultimate goal to increase quality, and hopefully, overall survival in this patient population. ..
  7. kappa-agonist effects of the hallucinogen Salvinorin A
    Eduardo Butelman; Fiscal Year: 2008
    ....
  8. Effect of ethanol on retinoid metabolism and signaling in zebrafish embryos
    WILLIAM BOSRON; Fiscal Year: 2007
    ..We will assess the feasibility of performing targeted proteomics studies with tissues from other populations that express different SNPs in alcohol metabolizing enzymes. [unreadable] [unreadable] [unreadable]..
  9. Retinoid Metabolism in Hepatitic Stellate Cells
    WILLIAM BOSRON; Fiscal Year: 2005
    ..Inhibitors of retinyl ester hydrolysis in stellate cells may be an effective therapeutic strategy for arresting stellate cell activation early in hepatic fibrosis. ..
  10. Colon Polyp Screening with Colonoscopy in Women
    Philip Schoenfeld; Fiscal Year: 2005
    ..Ultimately, the proposed research studies, didactic coursework, and mentoring hopefully will lead to successful R01 applications. ..
  11. Multi-site Trial of Azathioprine Dosing in Crohn Disease
    Stephen Hanauer; Fiscal Year: 2004
    ..Predictive models will be performed to assess responsiveness based upon initial and inducible TPMT activity and achievable 6-TGN and 6-MMPR metabolite based upon incremental AZA dosing. ..
  12. Xenogen's IVIS 100 Imaging System
    Mark Kieran; Fiscal Year: 2004
    ..This luciferase-based technology affords a superior method to achieve this aim. ..
  13. Multi-site Trial of Azathioprine Dosing in Crohn Disease
    Stephen Hanauer; Fiscal Year: 2003
    ..Predictive models will be performed to assess responsiveness based upon initial and inducible TPMT activity and achievable 6-TGN and 6-MMPR metabolite based upon incremental AZA dosing. ..
  14. PEDIATRIC BRAIN TUMOR CLINICAL TRIAL CONSORTIUM
    Michael Prados; Fiscal Year: 2003
    ..The aim of these treatment approaches is to increase disease-free and overall survival in children with brain tumors. ..
  15. HARVARD PEDIATRIC BRAIN TUMOR CENTER
    Mark Kieran; Fiscal Year: 2003
    ..David Louis). In summary, we will bring the full thrust of a Comprehensive Cancer Center and the full services of a pediatric center to enhance the Consortium and our mutual missions. ..
  16. CPT11 activation by carboxylesterases in colon cancer
    WILLIAM BOSRON; Fiscal Year: 2003
    ..If there is a positive correlation, a future multi-institutional study will be proposed. ..
  17. EFFECTS OF SYSTEMICALLY ADMINISTERED DYNORPHINS
    Eduardo Butelman; Fiscal Year: 2002
    ....