oxazines

Summary

Summary: Six-membered heterocycles containing an oxygen and a nitrogen.

Top Publications

  1. ncbi Comparison of first-line antiretroviral therapy with regimens including nevirapine, efavirenz, or both drugs, plus stavudine and lamivudine: a randomised open-label trial, the 2NN Study
    F van Leth
    International Antiviral Therapy Evaluation Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
    Lancet 363:1253-63. 2004
  2. ncbi Neonicotinoid insecticide toxicology: mechanisms of selective action
    Motohiro Tomizawa
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Annu Rev Pharmacol Toxicol 45:247-68. 2005
  3. ncbi Antimycobacterial screening of traditional medicinal plants using the microplate resazurin assay
    Duncan Webster
    Department of Medicine, Saint John Regional Hospital, Canada
    Can J Microbiol 56:487-94. 2010
  4. ncbi A new approach to drug discovery: high-throughput screening of microbial natural extracts against Aspergillus fumigatus using resazurin
    Maria Cândida Monteiro
    Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Armilla, Granada, Spain
    J Biomol Screen 17:542-9. 2012
  5. ncbi Detection of mitochondrial respiratory dysfunction in circulating lymphocytes using resazurin
    Khaled K Abu-Amero
    Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Arch Pathol Lab Med 129:1295-8. 2005
  6. ncbi Comparison of alamar blue and MTT assays for high through-put screening
    R Hamid
    Discovery Support, Purdue Pharma L P, 444 Saw Mill River Road, Ardsley, NY 10502, USA
    Toxicol In Vitro 18:703-10. 2004
  7. pmc Multiple applications of Alamar Blue as an indicator of metabolic function and cellular health in cell viability bioassays
    Sephra N Rampersad
    Department of Life Sciences, The University of the West Indies, West Indies, St Augustine, Trinidad and Tobago
    Sensors (Basel) 12:12347-60. 2012
  8. ncbi Selection of developmentally competent oocytes through brilliant cresyl blue stain enhances blastocyst development rate after bovine nuclear transfer
    S Bhojwani
    Research Unit Reproductive Biology, Research Institute for the Biology of Farm Animals, Wilhelm Stahl Allee 2, D 18196 Dummerstorf, Germany
    Theriogenology 67:341-5. 2007
  9. ncbi Rapid analysis of neonicotinoid insecticides in guttation drops of corn seedlings obtained from coated seeds
    Andrea Tapparo
    Universita degli Studi di Padova, Dipartimento di Scienze Chimiche, Via Marzolo 1, 35131 Padova, Italy
    J Environ Monit 13:1564-8. 2011
  10. ncbi Bovine blastocyst development rate in vitro is influenced by selection of oocytes by brillant cresyl blue staining before IVM as indicator for glucose-6-phosphate dehydrogenase activity
    H Alm
    Research Institute for the Biology of Farm Animals, 18196 Dummerstorf, Germany
    Theriogenology 63:2194-205. 2005

Research Grants

Detail Information

Publications259 found, 100 shown here

  1. ncbi Comparison of first-line antiretroviral therapy with regimens including nevirapine, efavirenz, or both drugs, plus stavudine and lamivudine: a randomised open-label trial, the 2NN Study
    F van Leth
    International Antiviral Therapy Evaluation Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
    Lancet 363:1253-63. 2004
    ..The 2NN Study was a randomised comparison of the non-nucleoside reverse-transcriptase inhibitors (NNRTI) nevirapine and efavirenz...
  2. ncbi Neonicotinoid insecticide toxicology: mechanisms of selective action
    Motohiro Tomizawa
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Annu Rev Pharmacol Toxicol 45:247-68. 2005
    ..The low affinity of neonicotinoids for vertebrate relative to insect nicotinic receptors is a major factor in their favorable toxicological profile...
  3. ncbi Antimycobacterial screening of traditional medicinal plants using the microplate resazurin assay
    Duncan Webster
    Department of Medicine, Saint John Regional Hospital, Canada
    Can J Microbiol 56:487-94. 2010
    ..maximum and Acorus calamus possess strong in vitro antimycobacterial activity, validates traditional knowledge, and provides potential for the development of urgently needed novel antituberculous therapeutics...
  4. ncbi A new approach to drug discovery: high-throughput screening of microbial natural extracts against Aspergillus fumigatus using resazurin
    Maria Cândida Monteiro
    Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Armilla, Granada, Spain
    J Biomol Screen 17:542-9. 2012
    ..Our group has been the first to use this methodology for screening a collection of natural extracts to identify compounds with antifungal activity against the medically important human pathogen A. fumigatus...
  5. ncbi Detection of mitochondrial respiratory dysfunction in circulating lymphocytes using resazurin
    Khaled K Abu-Amero
    Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Arch Pathol Lab Med 129:1295-8. 2005
    ....
  6. ncbi Comparison of alamar blue and MTT assays for high through-put screening
    R Hamid
    Discovery Support, Purdue Pharma L P, 444 Saw Mill River Road, Ardsley, NY 10502, USA
    Toxicol In Vitro 18:703-10. 2004
    ....
  7. pmc Multiple applications of Alamar Blue as an indicator of metabolic function and cellular health in cell viability bioassays
    Sephra N Rampersad
    Department of Life Sciences, The University of the West Indies, West Indies, St Augustine, Trinidad and Tobago
    Sensors (Basel) 12:12347-60. 2012
    ..This review seeks to highlight many of the important considerations involved in assay use and design in addition to the potential pitfalls...
  8. ncbi Selection of developmentally competent oocytes through brilliant cresyl blue stain enhances blastocyst development rate after bovine nuclear transfer
    S Bhojwani
    Research Unit Reproductive Biology, Research Institute for the Biology of Farm Animals, Wilhelm Stahl Allee 2, D 18196 Dummerstorf, Germany
    Theriogenology 67:341-5. 2007
    ..In addition, G6PDH activity could prove to be a useful marker for determining the oocyte quality in future...
  9. ncbi Rapid analysis of neonicotinoid insecticides in guttation drops of corn seedlings obtained from coated seeds
    Andrea Tapparo
    Universita degli Studi di Padova, Dipartimento di Scienze Chimiche, Via Marzolo 1, 35131 Padova, Italy
    J Environ Monit 13:1564-8. 2011
    ....
  10. ncbi Bovine blastocyst development rate in vitro is influenced by selection of oocytes by brillant cresyl blue staining before IVM as indicator for glucose-6-phosphate dehydrogenase activity
    H Alm
    Research Institute for the Biology of Farm Animals, 18196 Dummerstorf, Germany
    Theriogenology 63:2194-205. 2005
    ..In addition, G6PDH activity may be useful as a marker for oocyte quality in future studies on factors affecting developmental competence...
  11. ncbi Discontinuation of Atripla as first-line therapy in HIV-1 infected individuals
    Andrew Scourfield
    Department of HIV Medicine, Chelsea and Westminster Hospital, Chelsea, UK
    AIDS 26:1399-401. 2012
    ..We aimed to describe the outcomes of individuals commencing Atripla (Gilead Sciences Inc, Foster City, California; Bristol-Myers Squibb Co, Princeton, New Jersey, USA) as a first-line regimen...
  12. ncbi A high throughput Nile red method for quantitative measurement of neutral lipids in microalgae
    Wei Chen
    Department of Applied Biological Sciences, Arizona State University, Mesa, AZ 85212, USA
    J Microbiol Methods 77:41-7. 2009
    ..The 96-well plate-based Nile red method can be used as a high throughput technique for rapid screening of a broader spectrum of naturally-occurring and genetically-modified algal strains and mutants for high neutral lipid/oil production...
  13. ncbi Cross-resistance study and biochemical mechanisms of thiamethoxam resistance in B-biotype Bemisia tabaci (Hemiptera: Aleyrodidae)
    Yuntao Feng
    Department of Plant Protection, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, PR China
    Pest Manag Sci 66:313-8. 2010
    ..tabaci, a resistant strain was selected in the laboratory. Cross-resistance and the biochemical mechanisms of thiamethoxam resistance were investigated in the present study...
  14. ncbi Resazurin reduction assays for screening of anti-tubercular compounds against dormant and actively growing Mycobacterium tuberculosis, Mycobacterium bovis BCG and Mycobacterium smegmatis
    Neetu Kumra Taneja
    Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    J Antimicrob Chemother 60:288-93. 2007
    ..To develop simple, rapid, low-cost and robust assays for screening drugs against dormant and actively growing mycobacteria...
  15. ncbi Rapid decrease of intracellular pH associated with inhibition of Na+/H+ exchanger precedes apoptotic events in the MNK45 and MNK74 gastric cancer cell lines treated with 2-aminophenoxazine-3-one
    Hiroyuki Nagata
    Fourth Department of Surgery, Tokyo Medical University, Ibaragi Medical Center, 3 20 1 Chuo, Ami, Inashiki, Ibaraki 300 0395, Japan
    Oncol Rep 25:341-6. 2011
    ..Phx-3 is a good candidate for therapeutics of gastric cancer that is intractable to conventional chemopreventive therapies...
  16. ncbi Multicolor and electron microscopic imaging of connexin trafficking
    Guido Gaietta
    National Center for Microscopy and Imaging Research, Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Science 296:503-7. 2002
    ..Selective imaging by correlated optical and electron microscopy of protein molecules of known ages will clarify fundamental processes of protein trafficking in situ...
  17. pmc Gene expression profiling in the thiamethoxam resistant and susceptible B-biotype sweetpotato whitefly, Bemisia tabaci
    Wen Xie
    Department of Plant Protection, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081, China
    J Insect Sci 12:46. 2012
    ..The distributed profiles show that it was highly expressed during the egg stage, and was most abundant in the abdomen of adult females...
  18. ncbi Delayed toxicity as a critical factor in the efficacy of aqueous baits for controlling Argentine ants (Hymenoptera: Formicidae)
    Michael K Rust
    Department of Entomology, University of California, Riverside, Riverside, CA 92521 0314, USA
    J Econ Entomol 97:1017-24. 2004
    ..The utility of aqueous sucrose baits and toxicants soluble in such systems and the negative impact of fast-acting toxicants on trail following, recruitment, trophallaxis, and control of Argentine ants are discussed...
  19. pmc Surveying polypeptide and protein domain conformation and association with FlAsH and ReAsH
    Nathan W Luedtke
    Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520 8107, USA
    Nat Chem Biol 3:779-84. 2007
    ....
  20. ncbi Unique and common metabolites of thiamethoxam, clothianidin, and dinotefuran in mice
    Kevin A Ford
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Chem Res Toxicol 19:1549-56. 2006
    ..The diversity of biodegradable sites and multiple pathways insures against parent compound accumulation but provides intermediates reported to be active as nicotinic agonists and inducible nitric oxide synthase inhibitors...
  21. ncbi Dynamics of resistance to the neonicotinoids acetamiprid and thiamethoxam in Bemisia tabaci (Homoptera: Aleyrodidae)
    A Rami Horowitz
    Agricultural Research Organization, Department of Entomology, Gilat Research Center, M P Negev, 85280, Israel
    J Econ Entomol 97:2051-6. 2004
    ....
  22. ncbi An improved resazurin-based cytotoxicity assay for hepatic cells
    M K McMillian
    Department of Molecular Toxicology, The R W Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA
    Cell Biol Toxicol 18:157-73. 2002
    ....
  23. ncbi Selection of oocytes for in vitro maturation by brilliant cresyl blue staining: a study using the mouse model
    Yan Guang Wu
    Laboratory for Animal Reproduction and Embryology, College of Animal Science and Vet Medicine, Shandong Agricultural University, Tai an, Shandong, China
    Cell Res 17:722-31. 2007
    ..Taken together, the series of criteria described here would allow for better choices in selecting oocytes for better development...
  24. ncbi Synthesis, structural elucidation, DNA-PK inhibition, homology modelling and anti-platelet activity of morpholino-substituted-1,3-naphth-oxazines
    Saleh Ihmaid
    School of Pharmacy and Applied Science, La Trobe University, Bendigo, Australia
    Bioorg Med Chem 19:3983-94. 2011
    A number of new angular 2-morpholino-(substituted)-naphth-1,3-oxazines (compound 10b), linear 2-morpholino-(substituted)-naphth-1,3-oxazines (compounds 13b-c), linear 6, 7 and 9-O-substituted-2-morpholino-(substituted)-naphth-1,3-oxazines ..
  25. pmc 2-Aminophenoxazine-3-one and 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one cause cellular apoptosis by reducing higher intracellular pH in cancer cells
    Xiao Fang Che
    Department of Biochemistry, Tokyo Medical University, Tokyo, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 87:199-213. 2011
    ..Drugs such as Phx-3 and Phx-1 that reduce pHi and thereby induce cellular apoptosis might serve as benevolent anticancer drugs...
  26. ncbi Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated from fatty liver grafts
    M Teresa Donato
    Unidad de Hepatologia Experimental, Hospital Universitario La Fe, Avenida Campanar 21, 46009, Valencia, Spain
    Drug Metab Dispos 34:1556-62. 2006
    ..Our results suggest that although human hepatocytes isolated from steatotic liver show reduced P450 activities, they are metabolically competent and can be used for drug metabolism studies...
  27. ncbi Preliminary study in immature canine oocytes stained with brilliant cresyl blue and obtained from bitches with low and high progesterone serum profiles
    B A Rodrigues
    Laboratory of Embryology and Biotechnics of Reproduction, Faculty of Veterinary Medicine, UFRGS, Porto Alegre, RS, Brazil
    Reprod Domest Anim 44:255-8. 2009
    ..6 to 16.7 ng/ml (n = 4) (p = 0.680). It may be inferred that bitches with low and high SP profiles have grown oocytes in their ovaries, as determined by the BCB absorbance in their ooplasms...
  28. ncbi Chemistry and biology of thiamethoxam: a second generation neonicotinoid
    P Maienfisch
    Syngenta Crop Protection, Research and Technology, WRO 1060 1 14, CH 4002 Basel, Switzerland
    Pest Manag Sci 57:906-13. 2001
    ....
  29. ncbi 2-aminophenoxazine-3-one suppresses the growth of mouse malignant melanoma B16 cells transplanted into C57BL/6Cr Slc mice
    Naoko Miyano-Kurosaki
    Department of Life and Environmental Sciences, Faculty of Engineering, Chiba Institute of Technology, Japan
    Biol Pharm Bull 29:2197-201. 2006
    ..5 mg/kg. These results suggest that Phx-3 may be used to treat patients affected by malignant melanoma in future...
  30. pmc The influence of bacterial diet on fat storage in C. elegans
    Kyleann K Brooks
    School of Molecular Biosciences, Washington State University, Pullman, Washington, United States of America
    PLoS ONE 4:e7545. 2009
    ..C. elegans feed on bacteria, and various strains of E. coli are commonly used in research settings. However, it is not known whether particular bacterial diets affect fat storage and metabolism...
  31. ncbi Development of an Alamar Blue viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427
    Melissa L Sykes
    Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, Queensland, Australia
    Am J Trop Med Hyg 81:665-74. 2009
    ..42%. Drug sensitivity was compared with those reported from previously developed 96-well methods and was found to be comparable. The sensitivity and cost benefit of the Alamar Blue assay make it an excellent candidate for HTS application...
  32. ncbi A quantitative resazurin assay to determinate the viability of Trichomonas vaginalis and the cytotoxicity of organic solvents and surfactant agents
    Mariana Duarte
    Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Exp Parasitol 123:195-8. 2009
    ..These results contribute for pharmacological investigations of bioactive compounds that need the use of solvents as solubilization vehicles to test anti-Trichomonas activity...
  33. pmc Etifoxine improves peripheral nerve regeneration and functional recovery
    Christelle Girard
    Unité Mixte de Recherche 788, Institut National de la Sante et de la Recherche Medicale, and Université Paris Sud 11, 94276 Le Kremlin Bicetre Cedex, France
    Proc Natl Acad Sci U S A 105:20505-10. 2008
    ..This molecule, which easily enters nerve tissues and regulates multiple functions in a concerted manner, offers promise for the treatment of peripheral nerve injuries and axonal neuropathies...
  34. ncbi Discrepancies between metabolic activity and DNA content as tool to assess cell proliferation in cancer research
    Verena M C Quent
    Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
    J Cell Mol Med 14:1003-13. 2010
    ..Our results show certain discrepancies in terms of over-estimation of cell proliferation with respect to the metabolic assay in comparison to DNA binding fluorophores...
  35. ncbi Brilliant Cresyl Blue stain selects largest oocytes with highest mitochondrial activity, maturation-promoting factor activity and embryo developmental competence in prepubertal sheep
    Maria Gracia Catalá
    Departament de Ciencia Animal i dels Aliments, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
    Reproduction 142:517-27. 2011
    ..In conclusion, BCB stains larger and more competent oocytes to develop to the blastocyst stage with more active mitochondria and MPF activity and higher blastocyst cell number...
  36. ncbi Molecular and subcellular characterisation of oocytes screened for their developmental competence based on glucose-6-phosphate dehydrogenase activity
    Helmut Torner
    Department of Animal Breeding and Husbandry, Institute of Animal Science, University of Bonn, Endenicher Allee 15, 53115 Bonn, Germany
    Reproduction 135:197-212. 2008
    ..This study has evidenced molecular and subcellular organisational differences of oocytes with different G6PDH activity...
  37. pmc High-throughput screen for poly-3-hydroxybutyrate in Escherichia coli and Synechocystis sp. strain PCC6803
    Keith E Tyo
    Department of Chemical Engineering, MIT 56 469, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Appl Environ Microbiol 72:3412-7. 2006
    ..coli using fluorescence-activated cell sorting to identify mutants with increased PHB-accumulating properties...
  38. ncbi Resazurin assay of radiation response in cultured cells
    S Anoopkumar-Dukie
    Department of Pharmacology and Therapeutics, University College Cork, Ireland
    Br J Radiol 78:945-7. 2005
    ..5 at 60% isoeffect level versus 3.1 for the colony forming assay. Intraday and interday precisions for the resazurin assay were 4.1% and 5.2%, respectively...
  39. ncbi A close look at fluorescence quenching of organic dyes by tryptophan
    Soren Doose
    Applied Laser Physics and Laser Spectroscopy, University of Bielefeld, Universitatsstr 25, 33615 Bielefeld, Germany
    Chemphyschem 6:2277-85. 2005
    ....
  40. ncbi Rapid fluorescent assay for screening drugs on Leishmania amastigotes
    Orly Shimony
    The Kuvin Centre for the Study of Infectious and Tropical Diseases, Hebrew University Hadassah Medical School, P O Box 12272, Jerusalem 91220, Israel
    J Microbiol Methods 75:196-200. 2008
    ..This assay only requires a limited number of axenic amastigotes (50,000 cells/well) and can be used to rapidly screen large chemical or natural product libraries for activity against amastigotes...
  41. ncbi Determination of the dose-depth distribution of proton beam using resazurin assay in vitro and diode laser-induced fluorescence detection
    Min Jung Kim
    Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    Anal Chim Acta 593:214-23. 2007
    ....
  42. ncbi Identification of biochemical markers linked to neonicotinoid cross resistance in Bemisia tabaci (Hemiptera: Aleyrodidae)
    Natascha Rauch
    Bayer CropScience AG, Research, Global Biology Insecticides, Monheim, Germany
    Arch Insect Biochem Physiol 54:165-76. 2003
    ..Five-hydroxy-imidacloprid could be detected as the only main metabolite. The insecticidal activity and binding affinity to nAChR of this compound was 10 times lower than imidacloprid itself in B. tabaci...
  43. ncbi Cancer chemopreventive effect of phenothiazines and related tri-heterocyclic analogues in the 12-O-tetradecanoylphorbol-13-acetate promoted Epstein-Barr virus early antigen activation and the mouse skin two-stage carcinogenesis models
    Magnus A Azuine
    Laboratory of Natural Drug Products, Department of Pharmaceutical Sciences, School of Pharmacy, Howard University, 2300 4th Street, NW, Washington, DC 20059, USA
    Pharmacol Res 49:161-9. 2004
    ....
  44. ncbi Differentiation and apoptosis in human malignant melanoma G-361 cells induced by 2-aminophenoxazine-3-one
    Shigetaka Shimizu
    Department of Otorhinolaryngology, Tokyo Medical University, 5 7 1 Nishishinjuku, Tokyo 160 0023, Japan
    Oncol Rep 14:41-6. 2005
    ..The present results suggest that Phx-3 exclusively demonstrates anti-tumor activity against human malignant melanoma G-361 cells by inducing cell cycle accumulation at G1, differentiation and apoptosis...
  45. ncbi Developmental competence of heifer oocytes selected using the brilliant cresyl blue (BCB) test
    Marc Pujol
    Departament de Ciencia Animal i dels Aliments, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Bellaterra, Barcelona 08193, Spain
    Theriogenology 61:735-44. 2004
    ..However, fewer heifer oocytes selected using the BCB test develop to blastocyst stage compared to cow oocytes...
  46. ncbi Synergistic enhancement of TRAIL- and tumor necrosis factor alpha-induced cell death by a phenoxazine derivative
    Keiichi Hara
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Mol Cancer Ther 4:1121-7. 2005
    ..Considering that both TRAIL and Phx-1 have only marginal cytotoxicity to most normal cells, Phx-1 may provide an ideal combination for cancer therapy with TRAIL...
  47. ncbi Selectively induced apoptosis in human neutrophils in the presence of oxidative phenoxazines, 2-amino-4,4α-dihydryo-4α-7H-phenoxazine-3-one and 2-aminophenoxazine-3-one, preceded by decrease of intracellular pH, depolarization of the mitochondria, and inh
    Takanobu Tabuchi
    Fourth Department of Surgery, Tokyo Medical University, Ibaraki Medical Center, Ibaraki 300 0395, Japan
    J Pharmacol Sci 117:139-48. 2011
    ....
  48. ncbi Anticancer effects of phenoxazine derivatives combined with tumor necrosis factor-related apoptosis-inducing ligand on pancreatic cancer cell lines, KLM-1 and MIA-PaCa-2
    Seiko Kato
    Third Department of Internal Medicine, Tokyo Medical University, Tokyo 160 0023, Japan
    Oncol Rep 15:843-8. 2006
    ..These results suggest that both Phx-1 and Phx-3 exert anticancer effects against human pancreatic cancer cells, KLM-1 and MIA-PaCa-2, through distinct action modes. Phx-1 and Phx-3 may be effective for the treatment of pancreatic cancer...
  49. ncbi Identification of an orthogonal peptide binding motif for biarsenical multiuse affinity probes
    Baowei Chen
    Cell Biology and Biochemistry Group, Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Bioconjug Chem 18:1259-65. 2007
    ....
  50. ncbi Efavirenz induces a striking and generalized increase of HDL-cholesterol in HIV-infected patients
    Eugenia Negredo
    AIDS 18:819-21. 2004
  51. ncbi Phenoxazine derivatives inactivate human cytomegalovirus, herpes simplex virus-1, and herpes simplex virus-2 in vitro
    Kyoko Hayashi
    Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
    J Pharmacol Sci 106:369-75. 2008
    ..When HCMV was pretreated with Phx-2, concentration-dependent virucidal action was observed, suggesting that Phx-2 inactivates HCMV directly. From these data, it was found that Phx-2 might have a different anti-HCMV target from GCV...
  52. ncbi Comparison of XTT and Alamar blue assays in the assessment of the viability of various human cancer cell lines by AT-101 (-/- gossypol)
    Selim Uzunoglu
    Section of Molecular Biology, Department of Biology, Faculty of Science and Arts, Celal Bayar University, 45140, Muradiye, Manisa, Turkey
    Toxicol Mech Methods 20:482-6. 2010
    ....
  53. ncbi The use of the microplate alamar blue assay (MABA) to assess the susceptibility of Mycobacterium lepraemurium to anti-leprosy and other drugs
    Melby Mendoza-Aguilar
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, Carpio y Plan de Ayala, Colonia Santo Tomas, 11340, Mexico, D F, Mexico
    J Infect Chemother 18:652-61. 2012
    ..lepraemurium), in response to various drugs, thus offering a method to complement the study of murine leprosy, about which many questions remain unanswered...
  54. ncbi Measuring diffusion in cell membranes by fluorescence correlation spectroscopy
    Parijat Sengupta
    Department of Chemical Sciences, Tata Institute of Fundamental Research, Colaba, Mumbai 400005, India
    Methods 27:374-87. 2002
    ....
  55. ncbi A new non-radioactive method for IL-2 bioassay
    K Kwack
    Immunomodulation Research Center, University of Ulsan, Korea
    Mol Cells 10:575-8. 2000
    ..These results demonstrate that the alamarBlue assay is valid for the IL-2 bioassay and that alamarBlue can replace the [3H]thymidine employed in the conventional proliferation assays...
  56. ncbi Modulation of GABAergic synaptic transmission by the non-benzodiazepine anxiolytic etifoxine
    R Schlichter
    Laboratoire de Neurophysiologie Cellulaire et Intégrée, UMR 7519 CNRS, Universite Louis Pasteur, 21 rue René Descartes, 67084, Strasbourg Cedex, France
    Neuropharmacology 39:1523-35. 2000
    ..Our results indicate that etifoxine potentiates GABA(A) receptor-function by a direct allosteric effect and by an indirect mechanism involving the activation of PBRs...
  57. ncbi Single-molecule photophysics of oxazines on DNA and its application in a FRET switch
    Jan Vogelsang
    Angewandte Physik Biophysik and Center for NanoScience CeNS, Ludwig Maximilians Universitat Munchen, Amalienstr 54, 80799, Munchen, Germany
    Photochem Photobiol Sci 8:486-96. 2009
    ..For oxazines this control even allowed the separation of the influence of reducing and oxidizing agents, enabling switching ..
  58. pmc Hairpin structure of a biarsenical-tetracysteine motif determined by NMR spectroscopy
    Fatemeh Madani
    Department of Biochemistry and Biophysics, Arrhenius Laboratories, Stockholm University, SE 106 91 Stockholm, Sweden
    J Am Chem Soc 131:4613-5. 2009
    ..Phe1 was found to have an edge-face geometry relative to ReAsH. The close interaction between Phe1 and ReAsH may be highly significant for the fluorescence properties of the ReAsH complex...
  59. pmc Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
    Alexander A Soukas
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Genes Dev 23:496-511. 2009
    ..These data indicate that Rictor/TORC2 is a nutrient-sensitive complex with outputs to AKT and SGK to modulate the assessment of food quality and signal to fat metabolism, growth, feeding behavior, reproduction, and life span...
  60. ncbi Plasmodium berghei proteome changes in response to SSJ-183 treatment
    Jun Lu
    Drug Discovery Science Research Center, Hoshi University, Shinagawa, Tokyo, Japan
    Bioorg Med Chem 19:4144-7. 2011
    ..berghei. All three showed reduced expression after SSJ-183 treatment. This suggested that SSJ-183 was a good anti-malarial drug candidate because it targeted parasite chaperone proteins...
  61. ncbi Water-soluble Nile Blue derivatives: syntheses and photophysical properties
    Jiney Jose
    Department of Chemistry, Texas A and M University, Box 30012, College Station, TX 77841, USA
    Chemistry 15:418-23. 2009
    ..The new water-soluble materials 1 a, 1 b, 2 a, and 2 b emit in a desirable region of the fluorescence spectrum (lambda=670-675 nm). Overall they are potentially interesting for labeling biomolecules in aqueous environments...
  62. ncbi Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line
    N A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Appl Pharmacol 234:222-35. 2009
    ..Therefore, more than one assay may be required when determining nanoparticle toxicity for risk assessment...
  63. ncbi 2-aminophenoxazine-3-one prevents pulmonary metastasis of mouse B16 melanoma cells in mice
    Takayuki Hongo
    Department of Life and Environmental Sciences, Faculty of Engineering, Chiba Institute of Technology, Japan
    J Pharmacol Sci 114:63-8. 2010
    ..The present study suggests that Phx-3 might be a potential anti-metastatic agent as well as an anticancer agent...
  64. ncbi Microneedle-mediated intradermal nanoparticle delivery: Potential for enhanced local administration of hydrophobic pre-formed photosensitisers
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Photodiagnosis Photodyn Ther 7:222-31. 2010
    ..This study aimed to deliver a model hydrophobic dye, Nile red, into the skin using novel microneedle (MN) technology...
  65. ncbi Detection of inhibitors of phenotypically drug-tolerant Mycobacterium tuberculosis using an in vitro bactericidal screen
    Ian M Bassett
    School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
    J Microbiol 51:651-8. 2013
    ..Our library screen enabled detection of compounds with a potent level of bactericidal activity towards phenotypically drug-tolerant cultures of M. tuberculosis. ..
  66. ncbi Persistence and transformation of thiamethoxam, a neonicotinoid insecticide, in soil of different agroclimatic zones of India
    R Karmakar
    Division of Agricultural Chemicals, Indian Agricultural Research Institute, New Delhi 110012, India
    Bull Environ Contam Toxicol 76:400-6. 2006
  67. ncbi Probing the stereoselectivity of P-glycoprotein-synthesis, biological activity and ligand docking studies of a set of enantiopure benzopyrano[3,4-b][1,4]oxazines
    Ishrat Jabeen
    Department of Medicinal Chemistry, University of Vienna, Vienna, Austria
    Chem Commun (Camb) 47:2586-8. 2011
    A series of enantiomerically pure benzopyrano[3,4-b][1,4]oxazines have been synthesised and tested for their ability to inhibit P-glycoprotein...
  68. ncbi Selection of developmentally competent buffalo oocytes by brilliant cresyl blue staining before IVM
    B M Manjunatha
    Department of Animal Reproduction, Gynaecology and Obstetrics, Veterinary College, KVAFSU, Hebbal, Bangalore 560024, India
    Theriogenology 68:1299-304. 2007
    ..0%, P<0.05); blastocyst development was lowest in BCB- oocytes (5.2%). In conclusion, staining of buffalo oocytes with BCB before IVM may be used to select developmentally competent oocytes for increased in vitro embryo production...
  69. ncbi Soil dissipation and leaching behavior of a neonicotinoid insecticide thiamethoxam
    Suman Gupta
    Division of Agricultural Chemicals, Indian Agricultural Research Institute, New Delhi 110012, India
    Bull Environ Contam Toxicol 80:431-7. 2008
    ..Results showed that thiamethoxam has a potential to leach down under heavy rainfall conditions...
  70. ncbi Selection of immature pig oocytes for homologous in vitro penetration assays with the brilliant cresyl blue test
    J Roca
    Department of Animal Pathology, Veterinary Science, University of Murcia, Spain
    Reprod Fertil Dev 10:479-85. 1998
    ..05) of selection effectiveness and percentage of penetrated oocytes were obtained when blue oocytes were used. In summary, these results indicate that the BCB test improves hIVP performance when used to preselect immature oocytes...
  71. ncbi Fast and stable photochromic oxazines for fluorescence switching
    Erhan Deniz
    Laboratory for Molecular Photonics, Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, Florida 33146 0431, USA
    Langmuir 27:11773-83. 2011
    ....
  72. ncbi Supplementation with cysteamine during maturation and embryo culture on embryo development of prepubertal goat oocytes selected by the brilliant cresyl blue test
    Aixa Urdaneta
    Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Zygote 11:347-54. 2003
    ..The proportions of morulae plus blastocyst development were not affected by the treatments...
  73. ncbi An improved method for the rapid preparation of 2-amino-4,4a-dihydro-4a,7-dimethyl-3H-phenoxazine-3-one, a novel antitumor agent
    A Tomoda
    Department of Biochemistry, Tokyo Medical University, Japan
    Bioorg Med Chem Lett 11:1057-8. 2001
    ..These procedures yielded Phx in 34% yield...
  74. ncbi Evaluation of alkoxyresorufins as fluorescent substrates for cytochrome P450 BM3 and site-directed mutants
    Barbara M A Lussenburg
    LACDR Division of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
    Anal Biochem 341:148-55. 2005
    ..Of these compounds, 8 showed strong inhibition of the BROD activity, demonstrating for the first time that drug-like molecules also can bind with high affinity to BM3 mutants...
  75. ncbi Pirenoxine prevents oxidative effects of argon fluoride excimer laser irradiation in rabbit corneas: biochemical, histological and cytofluorimetric evaluations
    Miriam Cantore
    Department of Preclinical and Clinical Pharmacology, University of Florence, V le Pierraccini, 6, Florence, Italy
    J Photochem Photobiol B 78:35-42. 2005
    ..The experimental data indicate that oxidative and toxic effects are ascribable to ROS avalanches triggered by laser irradiation-induced photodissociation and are inhibited by pirenoxine...
  76. ncbi Anticancer effects of phenoxazine derivatives revealed by inhibition of cell growth and viability, disregulation of cell cycle, and apoptosis induction in HTLV-1-positive leukemia cells
    Naoko Miyano-Kurosaki
    Department of Life and Environmental Sciences, Chiba Institute of Technology, Japan
    J Pharmacol Sci 110:87-97. 2009
    ..The present results suggest that Phx-1, Phx-2, and, in particular, Phx-3 may be useful as therapeutic agents against ATL, which is extremely refractory to current therapies...
  77. ncbi Suppression of the proliferation of cancer cell lines, KB-3-1 and K562 cells preceded by a decrease in intracellular pH caused by phenoxazine derivatives
    Xiao Fang Che
    Department of Molecular Oncology, Advanced Therapeutics, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima 890 8544, Japan
    Oncol Rep 19:1253-8. 2008
    ..The present results suggest that the anti-cancer effects of Phx-3 and Phx-1 may be strengthened by the intracellular acidification of cancer cells by these compounds...
  78. ncbi Anticancer activity of phenoxazines produced by bovine erythrocytes on colon cancer cells
    Takeshi Nakachi
    Fourth Department of Surgery, Tokyo Medical University, Ibaraki Medical Center, Ibaraki 300 0395, Japan
    Oncol Rep 23:1517-22. 2010
    ..The present results demonstrate that Phx-1 and Phx-3, which were prepared by extensively improved methods using bovine erythrocytes, may be useful as therapeutic drugs against colon cancer that is intractable to chemotherapy...
  79. ncbi In vitro antibacterial activity of Phx-3 against Helicobacter pylori
    Tomoko Hanawa
    Department of Infectious Diseases, Division of Medical Microbiology, Kyorin University, School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    Biol Pharm Bull 33:188-91. 2010
    ..pylori were detected. In addition, induction of heat shock protein 60 was observed. Taken together, Phx-3 has antibacterial activity against Helicobacter pylori...
  80. ncbi Phenoxazine derivatives induce caspase-independent cell death in human glioblastoma cell lines, A-172 and U-251 MG
    Ken Shirato
    Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University, 2 579 15 Mikajima, Tokorozawa, Saitama 359 1192, Japan
    Oncol Rep 17:201-8. 2007
    ..In conclusion, Phx-1 and Phx-3 exert significant anti-cancer effects against human glioblastoma cell lines, A-172 and U-251 MG, mediated by the caspase-independent apoptotic cell death pathway...
  81. pmc Folding of the cocaine aptamer studied by EPR and fluorescence spectroscopies using the bifunctional spectroscopic probe Ç
    Pavol Cekan
    University of Iceland, Science Institute, Dunhaga 3, 107 Reykjavik, Iceland
    Nucleic Acids Res 37:3990-5. 2009
    ..The EPR data indicate that nucleotides in helix I are more mobile than nucleotides in regular duplex regions and may reflect increased dynamics due to the short length of helix I...
  82. ncbi Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-dihydro-2H-benzo[1,4]oxazines
    Benjamin Perry
    UCB, Medicinal Chemistry, Granta Park, Great Abington, Cambridge CB21 6GS, UK
    Bioorg Med Chem Lett 18:4700-4. 2008
    ..The SAR and pharmacokinetic profiles of a series of multi-isoform PI3K inhibitors based on a 3,4-dihydro-2H-benzo[1,4]oxazine scaffold are disclosed...
  83. ncbi Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling
    Kuntebommanahalli N Thimmaiah
    Department of Chemistry, Western Illinois University, Macomb 61455, USA
    J Biol Chem 280:31924-35. 2005
    ..Modeling studies suggest inhibitory phenoxazines may bind in the ATP-binding site, although ATP competition studies were unable to distinguish between competitive and noncompetitive inhibition...
  84. ncbi Antitumor activity of 2-amino-4,4alpha-dihydro-4alpha, 7-dimethyl-3H-phenoxazine-3-one against Meth A tumor transplanted into BALB/c mice
    H Mori
    Department of Public Health Pharmacy, Gifu Pharmaceutical University, Japan
    Anticancer Drugs 11:653-7. 2000
    ..These results show that Phx has strong anti-tumor activity, but exerts lower side effects and suggest that Phx is available for therapeutic purposes in the future...
  85. ncbi The phenoxazine derivative Phx-1 suppresses IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells
    Eisuke Enoki
    Division of Proteomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Japan
    J Pharmacol Sci 94:329-33. 2004
    ..These findings suggest that phenoxazine derivatives may have a therapeutic potential for allergic diseases by inhibiting mast cell degranulation...
  86. pmc Characterization and use of an unprecedentedly bright and structurally non-perturbing fluorescent DNA base analogue
    Peter Sandin
    Department of Chemical and Biological Engineering Physical Chemistry, Chalmers University of Technology, SE 41296 Gothenburg, Sweden
    Nucleic Acids Res 36:157-67. 2008
    ..g. photophysical studies of DNA interacting with macromolecules (proteins) or for determining size and shape of DNA tertiary structures using techniques such as fluorescence anisotropy and fluorescence resonance energy transfer (FRET)...
  87. ncbi 2-amino-phenoxazine-3-one attenuates glucose-induced augmentation of embryonic form of myosin heavy chain, endothelin-1 and plasminogen activator inhibitor-1 in human umbilical vein endothelial cells
    Gen Fukuda
    Third Department of Internal Medicine, Tokyo Medical University, Tokyo 160 0023, Japan
    Biol Pharm Bull 28:797-801. 2005
    ....
  88. ncbi A study on the perturbation of model lipid membranes by phenoxazines
    Andrzej B Hendrich
    Department of Biophysics, Wrocław Medical University, Wrocław, Poland
    Bioorg Med Chem 14:5948-54. 2006
    ..These studies showed also that phenoxazine molecules are located close to the polar/apolar interface of bilayer. The results allow to conclude that phenoxazines rather weakly interact with lipid bilayers...
  89. ncbi Identification of critical residues in novel drug metabolizing mutants of cytochrome P450 BM3 using random mutagenesis
    Barbara M A van Vugt-Lussenburg
    LACDR Division of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
    J Med Chem 50:455-61. 2007
    ..Computer modeling studies were used to rationalize the effects of the mutations. This study shows that random mutagenesis can be used to identify novel critical residues, and to increase our insight into P450s...
  90. ncbi Chlamydia pneumoniae growth inhibition in human monocytic THP-1 cells and human epithelial HEp-2 cells by a novel phenoxazine derivative
    Tomonori Uruma
    Department of Infectious Disease, Division of Microbiology, Kyorin University School of Medicine, Tokyo 181 8611, Japan
    J Med Microbiol 54:1143-9. 2005
    ..Thus, Phx-3 might be a useful compound for controlling C. pneumoniae growth in cells and may be an alternative conventional therapy...
  91. ncbi Intracellular lipophilic inclusions of mycobacteria in vitro and in sputum
    Natalie J Garton
    Department of Microbiology and Immunology and Department of Chemistry, University of Newcastle, Newcastle upon Tyne, UK
    Microbiology 148:2951-8. 2002
    ..These findings indicate that the uptake of long-chain fatty acids and TAG biosynthetic and degradative pathways are important aspects of mycobacterial lipid metabolism, meriting further investigation...
  92. ncbi Antitumor activity of a phenoxazine compound, 2-amino-4,4alpha-dihydro-4alpha,7-dimethyl-3H-phenoxazine-3-one against human B cell and T cell lymphoblastoid cell lines: induction of mixed types of cell death, apoptosis, and necrosis
    J Koshibu-Koizumi
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    J Cancer Res Clin Oncol 128:363-8. 2002
    ..We also studied whether Phx might cause apoptosis and necrosis in these cells...
  93. ncbi Antitumor effects of a novel phenoxazine derivative on human leukemia cell lines in vitro and in vivo
    T Shimamoto
    First Department of Internal Medicine, Tokyo Medical University, Japan
    Clin Cancer Res 7:704-8. 2001
    ..These results suggest that Phx may be used to treat patients affected by different types of leukemia...
  94. ncbi Susceptibility of adult hymenopteran parasitoids of the Nantucket pine tip moth (Lepidoptera: Tortricidae) to broad-spectrum and biorational insecticides in a laboratory study
    J T Nowak
    Department of Entomology, University of Georgia, Athens 30602, USA
    J Econ Entomol 94:1122-7. 2001
    ..Large-scale field trials are required to further define the impacts of these insecticides on natural enemies...
  95. ncbi Phenoxazine compounds produced by the reactions with bovine hemoglobin show antimicrobial activity against non-tuberculosis mycobacteria
    Shigetaka Shimizu
    Department of Otorhinolaryngology, Research Institute of Immunological Treatment, Tokyo Medical University, Tokyo 160 0032, Japan
    Tohoku J Exp Med 203:47-52. 2004
    ..tuberculosis, M. fortuitum, and M. smegmatis, and the concerned bacteria other than mycobacteria. The present results may contribute to development of novel antibiotics against non-tuberculolsis mycobacteria...
  96. ncbi Antioxidant protection in cultured corneal cells and whole corneas submitted to UV-B exposure
    Mario Ciuffi
    Department of Preclinical and Clinical Pharmacology, University of Florence, V le Pieraccini 6, Florence 50139, Italy
    J Photochem Photobiol B 71:59-68. 2003
    ..Mitochondrial viability was restored in epithelial cells of rabbit cornea but not in SIRCs. Moreover, both compounds are also able to increase ex vivo epithelial corneal cell defences against the in vitro UV-B induced lipid peroxidation...
  97. ncbi Ditopic complexation of selenite anions or calcium cations by pirenoxine: an implication for anti-cataractogenesis
    Jiahn Haur Liao
    Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan
    Inorg Chem 50:365-77. 2011
    ..These results may provide a rationale for using PRX as an anti-cataract agent and warrant further biological studies...
  98. ncbi In vitro assays for evaluating the ultraviolet B-induced damage in cultured human retinal pigment epithelial cells
    Hyun Yi Youn
    School of Optometry, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1
    J Photochem Photobiol B 88:21-8. 2007
    ....
  99. ncbi 2-Aminophenoxazine-3-one induces cellular apoptosis by causing rapid intracellular acidification and generating reactive oxygen species in human lung adenocarcinoma cells
    Chun Lei Zheng
    Department of Medical Oncology, Cancer Hospital, Fudan University, 200032, Shanghai, China
    Int J Oncol 36:641-50. 2010
    ....
  100. ncbi Anti-inflammatory and immunomodulatory properties of 2-amino-3H-phenoxazin-3-one
    Keizo Kohno
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    Biol Pharm Bull 31:1938-45. 2008
    ....
  101. ncbi Apoptosis induction preceded by mitochondrial depolarization in multiple myeloma cell line U266 by 2-aminophenoxazine-3-one
    Ken Shirato
    Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University, Tokorozawa, Saitama 359 1192, Japan
    Biol Pharm Bull 31:62-7. 2008
    ..These results support the view that Phx-3 may be utilized in future as chemotherapeutic agent against multiple myeloma which is extremely refractory to chemotherapy...

Research Grants62

  1. PHOTOTHERAPY OF BLADDER CANCER: NEW PHOTOSENSITIZERS
    Chi Wei Lin; Fiscal Year: 1991
    ..We are able to enhance the photoactivity of the oxazines buy modifying their structures; up to 65% absolute singlet oxygen yield has been achieved...
  2. CNS Viral Dynamics and Cellular Immunity During AIDS
    David Haas; Fiscal Year: 2009
    ..Characterizing these relationships will expand our knowledge regarding key events that lead to AIDS dementia, and may suggest novel approaches to other immunologic or viral-mediated diseases that affect the brain. ..
  3. VANDERBILT ADULT AIDS CLINICAL TRIALS UNIT
    David Haas; Fiscal Year: 2006
    ..The proposed ACTU will not only enroll patients into ACTG clinical trials, but will provide the ACTG the ability to address important questions concerning AIDS treatment and pathogenesis. ..
  4. Brain LC-PUFAs and Maternal Mental Health
    Beth Levant; Fiscal Year: 2006
    ..These findings will also suggest novel treatments for such illnesses when they occur. ..
  5. Brain DHA, Dopamine, and Behavior: Roles in ADHD
    Beth Levant; Fiscal Year: 2006
    ..Such insights may identify a means by which certain risk factors for ADHD may be reduced or eliminated or the severity of the disease may be reduced through appropriate pre- and postnatal nutrition. [unreadable] [unreadable]..
  6. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  7. COLUMBIA-ADARC-CORNELL AIDS CLINICAL TRIALS UNIT
    Scott Hammer; Fiscal Year: 2006
    ..Thus, the Columbia-ADARC ACTU will be an active participant in the Group's mission to improve the health of HIV infected individuals and set standards for treatment of HIV disease. ..
  8. NEW ENGLAND PROGRAM FOR AIDS CLINICAL TRIALS-PROACT (CPC
    Gerald Friedland; Fiscal Year: 2006
    ..Among the three ProACT sites we will enroll and follow 200 patients on study protocols at any given time over the course of this grant. ..
  9. ACYCLIC STEREOCONTROL IN RADICAL REACTIONS
    MUKUND SIBI; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  10. FURANOCOUMARINS AND DRUGS EFFECT ON CYP3A4
    Paul Watkins; Fiscal Year: 2007
    ..abstract_text> ..
  11. Role of D3 dopamine receptor in behavioral sensitization
    NEIL RICHTAND; Fiscal Year: 2007
    ..Significantly, these studies may also elucidate a previously unrecognized mechanism regulating receptor desensitization and trafficking relevant to other receptor systems and pathological conditions. ..
  12. Altered hypothalamic-pituitary-adrenal function in the Fragile X mouse
    JULIE LAUTERBORN; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  13. Cytochrome P450-reductase interactions in P450 1A subfamily
    GRAZYNA SZKLARZ; Fiscal Year: 2007
    ..Furthermore, this project will also provide opportunities for summer research by undergraduate students, as part of WV-BRIN and WV-INBRE programs. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  14. Afferent modulation in bladde dysfunction
    Naoki Yoshimura; Fiscal Year: 2007
    ..abstract not provided ..
  15. Genetic Analysis of Cortical Development in Mice
    Susan McConnell; Fiscal Year: 2007
    ....
  16. Fetal Alcohol Spectrum Disorders: A Science-Based Prevention Curriculum
    Kathleen Sulik; Fiscal Year: 2007
    ..The proposed classroom curriculum will provide a much-needed, hands-on scientific exploration of alcohol's effects on a developing organism, targeted to high school students. [unreadable] [unreadable] [unreadable]..
  17. Uridine Supplementation for HIV lipoatrophy
    Grace McComsey; Fiscal Year: 2007
    ..On-study subjects will continue to be followed per study protocol for a total of 12 months. The last 6 months of the grant will be dedicated to processing of samples and analysis of all data. [unreadable] [unreadable]..
  18. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2009
    ....
  19. Metabolic Consequences of Thymidine Sparing Regimens
    Grace A McComsey; Fiscal Year: 2010
    ..at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  20. AFFERENT PLASTICITY UNDERLYING URETHRAL AND PELVIC PAIN
    Naoki Yoshimura; Fiscal Year: 2010
    ..This is recognized as a high priority in the urologic care of patients with IC/CPPS. ..
  21. Overcoming HIV-1 resistance to RNA Interference
    Bharat Ramratnam; Fiscal Year: 2009
    ..In sum, our research will define the microbicidal potential of si/shRNA and may lead to the generation of new drugs that prevent the mucosal transmission of HIV-1. ..
  22. Role of Mitochondria in HIV Lipoatrophy
    Grace McComsey; Fiscal Year: 2009
    ..abstract_text> ..
  23. MODELS FOR TESTING CANDIDATE TOPICAL MICROBICIDES FOR CYTOTOXICITY AND ACTIVITY A
    Mary Lampe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  24. TDM & Drug Interactions in HIVinfected Substance Abusers
    Gene Morse; Fiscal Year: 2007
    ..abstract_text> ..
  25. Integrins and LTP consolidation
    Gary Lynch; Fiscal Year: 2008
    ..The results of these experiments are expected to provide a strong test of a specific hypothesis regarding how LTP, and therefore possibly memory, becomes consolidated. ..
  26. Lipodystrophy among HIV-infected patients
    Heidi Crane; Fiscal Year: 2008
    ..abstract_text> ..
  27. The impact of early antiretroviral therapy on HIV persistence and inflammation
    STEVEN GRANT DEEKS; Fiscal Year: 2010
    ..Our work may also provide important insights in the role of chronic inflammation in driving viral persistence, and hence may lead to the development of novel interventions. ..
  28. Differential Gene Expression in the Cochlear Nucleus
    David Friedland; Fiscal Year: 2008
    ..These data will also provide a powerful template upon which to test and design novel treatments for improving hearing, discrimination and tinnitus in a significant portion of the population. ..
  29. International Clinical Trials Unit
    John Bartlett; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  30. ADULT AIDS CLINICAL TRIALS UNIT
    John Bartlett; Fiscal Year: 2006
    ..The applicants anticipate that Duke will continue as an efficient, cost-effective ACTU that contributes to the ACTG scientific agenda. ..
  31. Novel HIV-1 Microbicides
    Bharat Ramratnam; Fiscal Year: 2006
    ..The full realization of this potential will come from more extended experiments involving vaginal/rectal virus challenge in CCR5 siRNA treated macaques and appropriate controls. ..
  32. PRESERVATION OF LIVER SPHEROIDS
    Lia Campbell; Fiscal Year: 2006
    ..Phase II studies will involve optimization for the best method of cryopreservation by either freezing or vitrification in anticipation of commercialization of mammalian liver spheroids. [unreadable] [unreadable] [unreadable]..
  33. Immunologic Control of Drug-resistant HIV-1
    Steven Deeks; Fiscal Year: 2005
    ..Finally, since we will estimate the relative in vivo thresholds for HIV-mediated immunogenicity and pathogenicity, these studies may also have implications for vaccine development. ..
  34. FACTORS IN PEDIATRIC AIDS TRANSMISSION AND PATHOGENESIS
    Stephen Spector; Fiscal Year: 2005
    ..The findings of this research will provide an improved understanding of the pathogenesis of HIV-1 infection of children and perinatal transmission, and help to develop improved treatment/prevention strategies. ..
  35. Bladder Pain Gene Therapy with Pro-opiomelanocortin cDNA
    Naoki Yoshimura; Fiscal Year: 2004
    ..This research project is important to provide a solid basis for potential future clinical application. ..
  36. DEVELOPMENT OF CRYOPLATES FOR CYTOTOXICITY TESTING
    Lia Campbell; Fiscal Year: 2004
    ..It is anticipated that optimization of procedures for corneal endothelial cells will provide a technology platform that can be applied, with further development, to other cell types. ..
  37. K24 MID-CAREER CLINICAL INVESTIGATOR AWARD
    John Bartlett; Fiscal Year: 2004
    ..These mentorship activities are strongly supported by leadership of the Department of Medicine and the Division of Infectious Diseases, and an AIDS Training Grant, which provides financial support for young investigators. ..
  38. NOVEL APPROACHES TO TARGET LATENT RESERVOIRS OF HIV-1
    Bharat Ramratnam; Fiscal Year: 2004
    ..The goal of this proposal will be to design and implement novel immunologic and pharmacologic interventions and characterize their effect on viral burden during prolonged anti-retroviral therapy. ..
  39. Kinase Inhibitors against Neurodegeneration
    Gary Lynch; Fiscal Year: 2004
    ....
  40. IDENTIFYING BRAIN WIRING MECHANISMS BY GENE TRAPPING
    Susan McConnell; Fiscal Year: 2004
    ..We expect that this method will help greatly accelerate the pace of discovery of mechanisms that direct the wiring of the mammalian nervous system. ..
  41. SYNTHESIS OF MDR REVERSING POLYENES
    MERRITT ANDRUS; Fiscal Year: 2003
    ..This is an important first step toward a molecular understanding of the unique recognition properties, transport mechanism of Pgp, and will further facilitate the design of new, more potent reversal agents. ..
  42. Lower urinary tract dysfunction in Parkinson's disease
    Naoki Yoshimura; Fiscal Year: 2003
    ..This is a high priority in the urologic care of patients with Parkinson's disease. ..
  43. AMYGDALOID FUNCTION IN FEAR CONDITIONING
    Stephen Maren; Fiscal Year: 2002
    ..The outcome of these experiments will have an important impact on current conceptions of both amygdaloid function and emotional learning and memory. ..
  44. ADOLESCENT MEDICINE TRIALS UNIT (AMTU)
    Stephen Spector; Fiscal Year: 2005
    ..The experience of our team in HIV care, clinical trials and laboratory studies, we believe, will enable our group to make a significant contribution to the success of the ATN. ..
  45. PEDIATRIC AIDS CLINICAL TRIALS GROUP
    Stephen Spector; Fiscal Year: 2006
    ..abstract_text> ..
  46. Endothelial Dysfunction Due to HIV-1 Protease Inhibitors
    Mitchell Goldman; Fiscal Year: 2006
    ..abstract_text> ..
  47. Non-nucleoside Reverse Transcriptive Hypersensitivity
    Nancy Shulman; Fiscal Year: 2006
    ....
  48. NEUROGENESIS AND MIGRATION IN DEVELOPING CEREBRAL CORTEX
    Susan McConnell; Fiscal Year: 2006
    ..Studies of normal development will provide insights into the ontogeny of developmental brain disorders in humans, and ultimately suggest strategies for the appropriate treatment of such disorders ..
  49. GENERAL CLINICAL RESEARCH CENTERS ANNUAL MEETING
    Paul Watkins; Fiscal Year: 2006
    ..abstract_text> ..
  50. MOLECULAR BIOLOGY OF INTERCELLULAR JUNCTIONS
    Daniel Goodenough; Fiscal Year: 2006
    ..If these connexins are expressed in retinal neurons, mouse lines with targeted gene knockouts of these connexins will be prepared and studied for functional consequences. ..
  51. Understanding and Altering the Virologic Setpoint
    Martin Markowitz; Fiscal Year: 2006
    ..abstract_text> ..
  52. DISORDERS OF NEURONAL MIGRATION AND EPILEPSY
    STEVEN ROPER; Fiscal Year: 2005
    ..These experiments will advance our understanding of cortical dysplasia and epilepsy and give greater insight the mechanisms that produce long-term impairment of inhibition after an isolated in utero injury. ..
  53. MECHANISMS OF WOUND HEALING WITH CULTURED HUMAN SKIN
    Steven Boyce; Fiscal Year: 2005
    ..Accomplishment of these objectives will contribute to reduced mortality and morbidity from burns, improved materials for plastic and reconstructive surgery, and development of other tissue and organ substitutes. ..
  54. Drug Resistance in Non-Subtype B HIV-1
    Susan Eshleman; Fiscal Year: 2005
    ..abstract_text> ..
  55. Pediatric ACTG Coordinating and Operations Center
    Stephen Spector; Fiscal Year: 2005
    ..abstract_text> ..
  56. Comparative In Vivo Biodistribution of Characterized Manufactured Nanomaterials
    Nancy A Monteiro Riviere; Fiscal Year: 2010
    ..These coordinated studies will provide data to link physical chemical characterizations to in vivo MNM disposition. ..
  57. STRUCTURE-FUNCTION STUDIES ON NITRILE HYDRATASE MODELS
    PRADIP MASCHARAK; Fiscal Year: 2003
    ..abstract_text> ..
  58. Monoclonal Antibody Therapy for Follicular Lymphoma
    Jonathan Friedberg; Fiscal Year: 2007
    ..abstract_text> ..
  59. Adrenal Cortical Cell Therapy
    James Dunn; Fiscal Year: 2008
    ..These studies will lead to a better understanding of the development of the adrenal cortex, as well as a new therapy that replaces the physiological function of the adrenal cortex. ..
  60. A new tumor marker for Ovarian Cancer
    Madhwa Raj; Fiscal Year: 2007
    ..The RCP test will be a valuable application of the use of cancer cell signatures as detection markers, which is a critical component of the 2001 Bypass Budget Document of NCI. ..