tetrachlorodibenzodioxin

Summary

Summary: A chemical by-product that results from burning or incinerating chlorinated industrial chemicals and other hydrocarbons. This compound is considered an environmental toxin, and may pose reproductive, as well as, other health risks for animals and humans.

Top Publications

  1. ncbi Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 453:65-71. 2008
  2. ncbi Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor
    J Mimura
    Department of Chemistry, Graduate School of Science, Tohoku University, Sendai, Japan
    Genes Cells 2:645-54. 1997
  3. pmc Identification of a novel mechanism of regulation of Ah (dioxin) receptor function
    J Mimura
    Department of Chemistry, Graduate School of Science, Tohoku University, Aoba ku, Sendai 980 8578, Japan
    Genes Dev 13:20-5. 1999
  4. ncbi Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity
    P M Fernandez-Salguero
    Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Toxicol Appl Pharmacol 140:173-9. 1996
  5. ncbi Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries
    Nathalie Tijet
    Department of Pharmacology, Medical Sciences Building, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Mol Pharmacol 69:140-53. 2006
  6. ncbi 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identification and measurement of TCDD metabolites
    O Sorg
    Dermato Toxicology, Swiss Centre for Applied Human Toxicology, and Department of Dermatology, University Hospital, Geneva, Switzerland
    Lancet 374:1179-85. 2009
  7. ncbi Modulation of the chemokines KC and MCP-1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice
    Christoph Franz Adam Vogel
    Department of Environmental Toxicology, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    Arch Biochem Biophys 461:169-75. 2007
  8. pmc Dioxin exposure and cancer risk in the Seveso Women's Health Study
    Marcella Warner
    Center for Environmental Research and Children s Health, School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
    Environ Health Perspect 119:1700-5. 2011
  9. pmc Dioxin and immune regulation: emerging role of aryl hydrocarbon receptor in the generation of regulatory T cells
    Nikki B Marshall
    Department of Microbiology, Environmental Health Sciences Center, Oregon State University, Corvallis, OR 97331, USA
    Ann N Y Acad Sci 1183:25-37. 2010
  10. ncbi AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines
    Sarah L Hockley
    Section of Molecular Carcinogenesis, The Institute of Cancer Research, Surrey, UK
    Chem Res Toxicol 20:1797-810. 2007

Research Grants

Detail Information

Publications323 found, 100 shown here

  1. ncbi Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 453:65-71. 2008
    ..Thus, AHR regulates both T(reg) and T(H)17 cell differentiation in a ligand-specific fashion, constituting a unique target for therapeutic immunomodulation...
  2. ncbi Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor
    J Mimura
    Department of Chemistry, Graduate School of Science, Tohoku University, Sendai, Japan
    Genes Cells 2:645-54. 1997
    ..In contrast to the role of AhR in the regulatory mechanism of xenobiotic-metabolizing enzymes, there is no direct proof that the AhR is involved in the teratogenic effects of TCDD...
  3. pmc Identification of a novel mechanism of regulation of Ah (dioxin) receptor function
    J Mimura
    Department of Chemistry, Graduate School of Science, Tohoku University, Aoba ku, Sendai 980 8578, Japan
    Genes Dev 13:20-5. 1999
    ..Thus, AhR and AhRR form a regulatory circuit in the xenobiotic signal transduction pathway and provide a novel mechanism of regulation of AhR function that may determine tissue-specific sensitivity to environmental pollutants...
  4. ncbi Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity
    P M Fernandez-Salguero
    Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Toxicol Appl Pharmacol 140:173-9. 1996
    ..The mechanism(s) responsible for these apparently receptor-independent processes remain unclear but may involve novel, alternative pathways for TCDD-induced toxicity...
  5. ncbi Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries
    Nathalie Tijet
    Department of Pharmacology, Medical Sciences Building, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Mol Pharmacol 69:140-53. 2006
    ..Overall, our study identifies a wide range of genes that depend on the AHR, either for constitutive expression or for response to TCDD...
  6. ncbi 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identification and measurement of TCDD metabolites
    O Sorg
    Dermato Toxicology, Swiss Centre for Applied Human Toxicology, and Department of Dermatology, University Hospital, Geneva, Switzerland
    Lancet 374:1179-85. 2009
    ..We monitored TCDD, its form, distribution, and elimination in Victor Yushchenko after he presented with severe poisoning...
  7. ncbi Modulation of the chemokines KC and MCP-1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice
    Christoph Franz Adam Vogel
    Department of Environmental Toxicology, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    Arch Biochem Biophys 461:169-75. 2007
    ....
  8. pmc Dioxin exposure and cancer risk in the Seveso Women's Health Study
    Marcella Warner
    Center for Environmental Research and Children s Health, School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
    Environ Health Perspect 119:1700-5. 2011
    ..The International Agency for Research on Cancer classified TCDD as a known human carcinogen, based on predominantly male occupational studies of increased mortality from all cancers combined...
  9. pmc Dioxin and immune regulation: emerging role of aryl hydrocarbon receptor in the generation of regulatory T cells
    Nikki B Marshall
    Department of Microbiology, Environmental Health Sciences Center, Oregon State University, Corvallis, OR 97331, USA
    Ann N Y Acad Sci 1183:25-37. 2010
    ..Although it is not yet clear how activation of AHR by TCDD induces Tregs, there is a potential therapeutic role for alternative AHR ligands in the treatment of immune-mediated disorders...
  10. ncbi AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines
    Sarah L Hockley
    Section of Molecular Carcinogenesis, The Institute of Cancer Research, Surrey, UK
    Chem Res Toxicol 20:1797-810. 2007
    ..Promoter analysis identified candidate genes for direct transcriptional regulation by either AHR or p53. These analyses have further dissected and characterized the complex cellular response to BaP...
  11. pmc Comparative analysis of AhR-mediated TCDD-elicited gene expression in human liver adult stem cells
    Suntae Kim
    Department of Biochemistry and Molecular Biology, 501 Biochemistry Building, Wilson Road, East Lansing, MI 48824 1319, USA
    Toxicol Sci 112:229-44. 2009
    ..Although some common pathways are affected, the results suggest that TCDD elicits species- and model-specific gene expression profiles...
  12. pmc A geographic information system for characterizing exposure to Agent Orange and other herbicides in Vietnam
    Jeanne Mager Stellman
    Department of Health Policy and Management, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 111:321-8. 2003
    ..To facilitate widespread use of the GIS, a user-friendly software package was developed to permit researchers to assign exposure opportunity indexes to troops, locations, or individuals...
  13. pmc Aryl hydrocarbon receptor (AhR) agonists suppress interleukin-6 expression by bone marrow stromal cells: an immunotoxicology study
    Brenda A Jensen
    Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    Environ Health 2:16. 2003
    ..Here, we extend these studies to evaluate the potential for two prototypic AhR agonists, 7,12-dimethylbenz [a]anthracene (DMBA) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), to alter stromal cell cytokine responses...
  14. pmc Aryl hydrocarbon receptor activation reduces dendritic cell function during influenza virus infection
    Guang Bi Jin
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Toxicol Sci 116:514-22. 2010
    ..Moreover, our results reinforce the idea that environmental signals and AhR ligands may contribute to differential susceptibilities and responses to respiratory infection...
  15. ncbi Functional role of AhR in the expression of toxic effects by TCDD
    Junsei Mimura
    Department of Biomolecular Science, Graduate School of Life Science, Tohoku University, Aoba ku, 980 8578, Sendai, Japan
    Biochim Biophys Acta 1619:263-8. 2003
    ..We summarize the present knowledge about functional role of AhR in TCDD-induced biological effects...
  16. ncbi Health status of Army Chemical Corps Vietnam veterans who sprayed defoliant in Vietnam
    Han K Kang
    Veterans Health Administration, Department of Veterans Affairs, Washington, District of Columbia 20420, USA
    Am J Ind Med 49:875-84. 2006
    ..This study examined the long-term health effects associated with herbicide exposure among these Vietnam veterans...
  17. pmc In vivo-in vitro toxicogenomic comparison of TCDD-elicited gene expression in Hepa1c1c7 mouse hepatoma cells and C57BL/6 hepatic tissue
    Edward Dere
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing MI 48824 1319, USA
    BMC Genomics 7:80. 2006
    ....
  18. ncbi Diabetes and cancer in veterans of Operation Ranch Hand after adjustment for calendar period, days of spraying, and time spent in Southeast Asia
    Joel E Michalek
    Department of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio, Texas 78229, USA
    J Occup Environ Med 50:330-40. 2008
    ..The Air Force Health Study was launched in 1980 as part of a Federal effort to resolve the Agent Orange issue...
  19. pmc Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development
    J V Schmidt
    Department of Molecular Pharmacology, Northwestern University Medical School, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 93:6731-6. 1996
    ....
  20. ncbi Induction of cytochrome P4501A1
    J P Whitlock
    Department of Molecular Pharmacology, Stanford University School of Medicine, California 94305 5332, USA
    Annu Rev Pharmacol Toxicol 39:103-25. 1999
    ....
  21. pmc Aryl hydrocarbon receptor activation by TCDD reduces inflammation associated with Crohn's disease
    Jenna M Benson
    Department of Biomedical and Pharmaceutical Sciences, Center for Environmental Health Sciences, University of Montana, Missoula, Montana 59812, USA
    Toxicol Sci 120:68-78. 2011
    ..Ultimately, this work may lead to the development of more effective therapeutics for the treatment of Crohn's disease...
  22. pmc Comparative analysis of dioxin response elements in human, mouse and rat genomic sequences
    Y V Sun
    Department of Biochemistry and Molecular Biology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
    Nucleic Acids Res 32:4512-23. 2004
    ..These results suggest that AhR-mediated gene expression may not be well conserved across species, which could have significant implications in human risk assessment...
  23. ncbi Ah receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functions
    Karl Walter Bock
    Department of Toxicology, Institute of Pharmacology and Toxicology, University of Tubingen, Tubingen, Germany
    Biochem Pharmacol 72:393-404. 2006
    ..Though important issues remain unresolved, the commentary is intended to stimulate efforts to understand dioxin-mediated toxic responses with emphasis on carcinogenesis in comparison with AhR-mediated physiologic functions...
  24. ncbi Suppression mechanisms of flavonoids on aryl hydrocarbon receptor-mediated signal transduction
    Rie Mukai
    Department of Agrobioscience, School of Agricultural Science, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
    Arch Biochem Biophys 501:134-41. 2010
    ..The inhibition of MEK/ERK phosphorylation is one of the mechanisms by which flavanones and catechins suppress the AhR-mediated signal transduction in Hepa-1c1c7 cells...
  25. ncbi Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipogenic differentiation and insulin-induced glucose uptake in 3T3-L1 cells
    Hsin Fen Hsu
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan
    J Hazard Mater 182:649-55. 2010
    ..These results provide in vitro evidence of TCDD's effects on fat cell metabolism, suggesting dioxin exposure in development of insulin resistance and type II diabetes...
  26. ncbi Severe 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) intoxication: kinetics and trials to enhance elimination in two patients
    Alexandra Geusau
    Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases, University of Vienna, Medical School, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Arch Toxicol 76:316-25. 2002
    ..When employed twice a week, the amount of TCDD excreted by this method was comparable to fecal excretion. In view of costs and time involved, LDL-apheresis does not seem to be justified for enhancement of TCDD elimination...
  27. pmc Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin administration and high-fat diet on the body weight and hepatic estrogen metabolism in female C3H/HeN mice
    Bao Ting Zhu
    Department of Pharmacology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Toxicol Appl Pharmacol 226:107-18. 2008
    ....
  28. ncbi Expression of aryl hydrocarbon receptor repressor in normal human tissues and inducibility by polycyclic aromatic hydrocarbons in human tumor-derived cell lines
    Yuki Tsuchiya
    Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, Takara machi 13 1, Kanazawa 920 0934, Japan
    Toxicol Sci 72:253-9. 2003
    ..The chemical-specific inducibility of AhRR was also similar to that of the CYP1 family determined in our previous study. These results indicated that AhRR is also induced in chemical- and cell-specific manners...
  29. ncbi Effects of chronic exposure to DDT and TCDD on disease activity in murine systemic lupus erythematosus
    J Li
    Department of Endocrinology and Metabolism, The First Affiliated Hospital, China Medical University, Shenyang, PR China
    Lupus 18:941-9. 2009
    ..TCDD was immunosuppressive to murine SLE. Xenoestrogens may have compound- and tissue-specific effects that require further elucidation in future work...
  30. ncbi Altered protein profile and possible hypoxia in the placenta of 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed rats
    Ryuta Ishimura
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Toxicol Appl Pharmacol 185:197-206. 2002
    ..Finally, the results of this study suggested the possibility that the increased incidence of fetal death after exposure to TCDD was due to the placental hypoxia...
  31. ncbi Histological analysis of acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in zebrafish
    Jeanmarie M Zodrow
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
    Aquat Toxicol 66:25-38. 2004
    ..Overall, TCDD exposure in adult zebrafish leads to histopathology similar to that reported in other fish species, and it appears unlikely that the histopathology in these organs completely explains the inhibition of fin regeneration...
  32. ncbi The aryl hydrocarbon receptor displaces p300 from E2F-dependent promoters and represses S phase-specific gene expression
    Jennifer L Marlowe
    Center for Environmental Genetics and the Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    J Biol Chem 279:29013-22. 2004
    ..The AHR seems to act as an environmental checkpoint that senses exposure to environmental toxicants and responds by signaling cell cycle inhibition...
  33. ncbi A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999-2002
    Duk Hee Lee
    Department of Preventive Medicine, School of Medicine, Kyungpook University, 101 Dongin dong, Jung Gu, Daegu, Korea 700 422
    Diabetes Care 29:1638-44. 2006
    ..Low-level exposure to some persistent organic pollutants (POPs) has recently become a focus because of their possible link with the risk of diabetes...
  34. ncbi Signaling pathway for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced TNF-alpha production in differentiated THP-1 human macrophages
    Hyeonjoo Cheon
    Department of Biochemistry, Korean Institute of Molecular Medicine and Nutrition, Korea University College of Medicine, Seoul 136 705, Korea
    Exp Mol Med 39:524-34. 2007
    ..A signaling pathway is proposed where TCDD induces sequential activation of AhR, EGFR and ERK, leading to the increased expression of TNF-alpha...
  35. ncbi 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters the differentiation pattern of human keratinocytes in organotypic culture
    J A Loertscher
    Department of Pathology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Toxicol Appl Pharmacol 175:121-9. 2001
    ..This TCDD-induced effect on differentiation-specific proteins results in profound changes in the tissue architecture...
  36. pmc Deletion of the aryl hydrocarbon receptor enhances the inflammatory response to Leishmania major infection
    Guillermo Elizondo
    Centro de Investigacion y Estudios Avanzados del Instituto Politecnico Nacional, Departamento de Biologia Celular, Av IPN 2508, San Pedro Zacatenco, C P 07360, Mexico D F, Mexico
    Int J Biol Sci 7:1220-9. 2011
    ..This decrease was associated with a reduction in Foxp3 mRNA levels. Finally, the alteration in the cytokine profile results in a better resolution of the L. major infection...
  37. ncbi Cross-species comparisons of transcriptomic alterations in human and rat primary hepatocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Michael B Black
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 127:199-215. 2012
    ..The results provide evidence for divergent cross-species gene expression changes in response to TCDD and are consistent with epidemiological and clinical evidence showing humans to be less sensitive to TCDD-induced hepatotoxicity...
  38. ncbi Inhibition of neovascularization by environmental agents
    Irena Ivnitski-Steele
    College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Cardiovasc Toxicol 5:215-26. 2005
    ..Thus, additional research also is needed to identify those environmental agents that mediate their toxicity by disrupting neovascularization...
  39. ncbi Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7
    X Coumoul
    , , , France
    Cancer Res 61:3942-8. 2001
    ..These results show that xenoestrogens, by altering the ratio of CYP1B1/CYP1A1, could redirect estradiol metabolism in a more toxic pathway in the breast cell line MCF-7...
  40. ncbi TCDD (2,3,7,8-tetrachlorodibenzo-P-dioxin) causes reduction in glucose uptake through glucose transporters on the plasma membrane of the guinea pig adipocyte
    E Enan
    Dept of Environmental Toxicology, University of California, Davis 95620
    J Environ Sci Health B 27:495-510. 1992
    ..These findings may contribute to a better understanding of dioxin-induced "wasting syndrome"...
  41. pmc Altered operant responding for motor reinforcement and the determination of benchmark doses following perinatal exposure to low-level 2,3,7,8-tetrachlorodibenzo-p-dioxin
    V P Markowski
    Department of Psychology, University of Southern Maine, Portland, Maine, USA
    Environ Health Perspect 109:621-7. 2001
    ..71 ng/kg with a 95% lower bound of 0.60. These values should be viewed from the perspective of current human body burdens, whose average value, based on TCDD toxic equivalents, has been calculated as 13 ng/kg...
  42. pmc Controlling viral immuno-inflammatory lesions by modulating aryl hydrocarbon receptor signaling
    Tamara Veiga-Parga
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, United States of America
    PLoS Pathog 7:e1002427. 2011
    ..Since a single TCDD administration given after the disease process had been initiated generated long lasting anti-inflammatory effects, the approach holds promise as a therapeutic means of controlling virus induced inflammatory lesions...
  43. ncbi Maternal exposure to high levels of dioxins in relation to birth weight in women affected by Yusho disease
    Kiyomi Tsukimori
    Department of Obstetrics, Fukuoka Children s Hospital, Japan
    Environ Int 38:79-86. 2012
    ..In Japan in 1968, an accidental human exposure to rice oil contaminated with PCDDs, PCDFs, and PCBs, led to the development of Yusho disease...
  44. pmc The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways
    Alvaro Puga
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA
    Biochem Pharmacol 77:713-22. 2009
    ..Ultimately, the effect of a particular AHR ligand may depend as much on the adaptive interactions that it established with pathways and proteins expressed in a specific cell or tissue as on the toxic responses that it raises...
  45. ncbi In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats disrupts brain sexual differentiation
    Masahiko Ikeda
    University of Shizuoka, Graduate School of Nutritional and Environmental Sciences, Japan
    Toxicol Appl Pharmacol 205:98-105. 2005
    ....
  46. pmc Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas
    J T Buters
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:1977-82. 1999
    ....
  47. ncbi Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice
    Darrell R Boverhof
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 94:398-416. 2006
    ....
  48. ncbi The transcription factor aryl hydrocarbon receptor nuclear translocator functions as an estrogen receptor beta-selective coactivator, and its recruitment to alternative pathways mediates antiestrogenic effects of dioxin
    Joëlle Rüegg
    Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden
    Mol Endocrinol 22:304-16. 2008
    ..Moreover, we show for the first time that the inhibitory effects of dioxin are more pronounced on ERbeta than on ERalpha...
  49. ncbi Identification of functional domains of the aryl hydrocarbon receptor
    B N Fukunaga
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles 90095 1786, USA
    J Biol Chem 270:29270-8. 1995
    ....
  50. pmc Prevalence of metabolic syndrome associated with body burden levels of dioxin and related compounds among Japan's general population
    Hirokazu Uemura
    Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Environ Health Perspect 117:568-73. 2009
    ..Environmental exposure to some persistent organic pollutants has been reported to be associated with a metabolic syndrome in the U.S. population...
  51. pmc CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor
    Bin Zhao
    Department of Environmental Toxicology, University of California, Davis, California 95616 8588, USA
    Toxicol Sci 117:393-403. 2010
    ....
  52. ncbi Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase
    A Poland
    J Biol Chem 251:4936-46. 1976
    ....
  53. pmc Activation of aryl hydrocarbon receptor by TCDD prevents diabetes in NOD mice and increases Foxp3+ T cells in pancreatic lymph nodes
    Nancy I Kerkvliet
    Oregon State University, Department of Microbiology, Corvallis, OR 97331, USA
    Immunotherapy 1:539-47. 2009
    ..Taken together, the data suggest that AHR activation by TCDD-like ligands may represent a novel avenue for treatment of immune-mediated diseases...
  54. pmc RelB, a new partner of aryl hydrocarbon receptor-mediated transcription
    Christoph F A Vogel
    Department of Environmental Toxicology, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    Mol Endocrinol 21:2941-55. 2007
    ..The interaction of RelB with AhR signaling, and AhR with NF-kappaB RelB signaling pathways represent a new mechanism of cross talk between the two transcription factors...
  55. ncbi Dioxin- and POP-contaminated sites--contemporary and future relevance and challenges: overview on background, aims and scope of the series
    Roland Weber
    POPs Environmental Consulting, Ulmenstrasse 3, 73035 Göppingen, Germany
    Environ Sci Pollut Res Int 15:363-93. 2008
    ..It also details the various strategies used to assess these historical legacies of contamination and the concepts developed, or which are under development, to effect their remediation...
  56. ncbi The extent and patterns of usage of Agent Orange and other herbicides in Vietnam
    Jeanne Mager Stellman
    Department of Health Policy and Management, Mailman School of Public Health, Columbia University, 600 West 168th Street, New York, New York 10032, USA
    Nature 422:681-7. 2003
    ..Our identification of specific military herbicide targets has led to a more coherent understanding of spraying. Common errors in earlier interpretations of the spray data are also discussed...
  57. ncbi Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDD-Mediated hepatotoxicity
    Darrell R Boverhof
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing Michigan 48824 1319, USA
    Toxicol Sci 85:1048-63. 2005
    ..Collectively, the data support a proposed mechanism for TCDD-mediated hepatotoxicity, including fatty liver, which involves mobilization of peripheral fat and inappropriate increases in hepatic uptake of fatty acids...
  58. ncbi Liver tumor-promoting activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in TCDD-sensitive and TCDD-resistant rat strains
    M Viluksela
    Laboratory of Toxicology, National Public Health Institute, Kuopio, Finland
    Cancer Res 60:6911-20. 2000
    ..Understanding the role of transactivation domain of the aryl hydrocarbon receptor in carcinogenesis is therefore likely to improve dioxin risk assessment...
  59. ncbi Cell death and impairment of glucose-stimulated insulin secretion induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the beta-cell line INS-1E
    Simona Piaggi
    Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, Sezione di Patologia Generale, Pisa, Italy
    Toxicol Appl Pharmacol 220:333-40. 2007
    ..On the basis of this latter observation we suggest that pancreatic beta-cells could be considered a specific and sensitive target for dioxin toxicity...
  60. pmc Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor alpha to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promoters
    Jason Matthews
    Department of Biosciences at Novum, Karolinska Institutet, Novum 14157, Sweden
    Mol Cell Biol 25:5317-28. 2005
    ..Our data suggest that ERalpha acts as a coregulator of AhR-mediated transcriptional activation and that the recruitment of ERalpha by AhR represents a novel mechanism AhR-ERalpha cross talk...
  61. ncbi Neurodevelopmental defects in zebrafish (Danio rerio) at environmentally relevant dioxin (TCDD) concentrations
    Adrian Hill
    Laboratory for Environmental Gene Regulation, School of Biological Sciences, Biosciences Building, University of Liverpool, Crown Street, Liverpool Merseyside L69 7ZB, United Kingdom
    Toxicol Sci 76:392-9. 2003
    ..This disruption of neuronal development provides the basis for understanding the neurotoxic effects of these compounds...
  62. pmc Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River
    Isaac Wirgin
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Science 331:1322-5. 2011
    ..This mechanistic basis of resistance in a vertebrate population provides evidence of evolutionary change due to selective pressure at a single locus...
  63. ncbi 2,3,7,8-Tetrachlorodibenzo-p-dioxin activation of the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator pathway causes developmental toxicity through a CYP1A-independent mechanism in zebrafish
    Sara A Carney
    Molecular and Environmental Toxicology Center, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705, USA
    Mol Pharmacol 66:512-21. 2004
    ..This suggests an alternative model in which TCDD-activated AHR/ARNT disrupts the normal process of growth and development by altering programs of gene expression or function...
  64. ncbi Aryl hydrocarbon receptor 2 mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin developmental toxicity in zebrafish
    Amy L Prasch
    Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin 53726, USA
    Toxicol Sci 76:138-50. 2003
    ..Most strikingly, zfahr2 morphants exposed to TCDD never developed edema. Taken together, these results demonstrate that zfAHR2 mediates several endpoints of TCDD developmental toxicity in zebrafish...
  65. ncbi Impact of Agent Orange exposure among Korean Vietnam veterans
    Joung Soon Kim
    Department of Epidemiology, School of Public Health, Seoul National University, 28 Yunkeun dong, Chongno Ku, Seoul 110 799, Republic of Korea
    Ind Health 41:149-57. 2003
    ..01), valvular heart disease (p < 0.01), and retinopathy (p < 0.01). We conclude that exposure to Agent Orange is associated with various health impacts in Korean Vietnam veterans...
  66. ncbi Cloning of a factor required for activity of the Ah (dioxin) receptor
    E C Hoffman
    Department of Pathology, University of California, Los Angeles 90024
    Science 252:954-8. 1991
    ..Another segment of the protein shows conformity to the consensus sequence for the basic helix-loop-helix motif found in proteins that bind DNA as homodimers or heterodimers...
  67. ncbi Identification of the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole, in cell culture medium, as a factor that controls the background aryl hydrocarbon receptor activity
    Mattias Oberg
    Institute of Environmental Medicine, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Toxicol Sci 85:935-43. 2005
    ..These results clearly show that tryptophan derived AhR ligands, which have been suggested to be endogenous AhR ligands, influence the background levels of CYP1A1 activity in cells in culture...
  68. ncbi Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology
    Prabir K Mandal
    Department of Biology, University of North Florida, 4567 St John s Bluff Road South, Jacksonville, FL, 32224, USA
    J Comp Physiol B 175:221-30. 2005
    ....
  69. ncbi Dioxins and human toxicity
    Natalija Marinković
    Department of Chemistry and Biochemistry, Zagreb University School of Medicine, Salata 3, Zagreb, Croatia
    Arh Hig Rada Toksikol 61:445-53. 2010
    ..The most sensitive population to dioxin exposure are the foetuses and infants.A large number of health effects have been documented in the scientific literature, and they all place dioxins among the most toxic chemicals known to man...
  70. ncbi 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs an insulin signaling pathway through the induction of tumor necrosis factor-alpha in adipocytes
    Shin Nishiumi
    Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Kobe, Hyogo 650 0017, Japan
    Toxicol Sci 115:482-91. 2010
    ....
  71. pmc An overview of the effects of dioxins and dioxin-like compounds on vertebrates, as documented in human and ecological epidemiology
    Sally S White
    National Center for Environmental Assessment, U S Environmental Protection Agency, North Carolina, USA
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 27:197-211. 2009
    ..Given these concerns, prudent public health policy should include the continued reduction of exposures...
  72. pmc TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F(0)F(1)-ATP synthase and ubiquinone
    Howard G Shertzer
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, P O Box 670056 Cincinnati, OH 45267 0056, USA
    Toxicol Appl Pharmacol 217:363-74. 2006
    ..This acts in concert with glutathione to increase membrane potential and reactive oxygen production. The proposed defect in ATP synthase explains both the greater respiratory rates and the lower tissue ATP levels...
  73. ncbi Aryl hydrocarbon receptor expression and activity in cerebellar granule neuroblasts: implications for development and dioxin neurotoxicity
    Mary A Williamson
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Toxicol Sci 83:340-8. 2005
    ..These data suggest that (1) granule neuroblasts are direct targets for developmental AhR-mediated TCDD neurotoxicity and (2) TCDD exposure may disrupt granule cell neurogenesis...
  74. ncbi Carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in experimental models
    Stefanie Knerr
    Food Chemistry and Environmental Toxicology, University of Kaiserslautern, Kaiserslautern, Germany
    Mol Nutr Food Res 50:897-907. 2006
    ..The final aim of these efforts is a more reliable risk assessment for the carcinogenic potency of the class of dioxinlike contaminants in humans...
  75. ncbi Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor
    H Reyes
    Department of Pathology, University of California, Los Angeles 90024
    Science 256:1193-5. 1992
    ..Arnt contains a basic helix-loop-helix motif, which may be responsible for interacting with both the XRE and the ligand-binding subunit...
  76. ncbi Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strain
    R Pohjanvirta
    National Public Health Institute, Department of Environmental Medicine, FIN 70701 Kuopio, Finland
    Mol Pharmacol 54:86-93. 1998
    ..These findings suggest that there is a relatively small region in the AhR trans-activation domain that may be capable of providing selectivity to its function...
  77. ncbi Disruption of thyroid hormone homeostasis at weaning of Holtzman rats by lactational but not in utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Noriko Nishimura
    Endocrine Disruptors and Dioxin Research Project, National Institute for Environmental Studies, Tsukuba 305 8506, Japan
    Toxicol Sci 85:607-14. 2005
    ..The present results demonstrate that lactational, but not in utero, exposure to TCDD was responsible for the disruption of thyroid hormone homeostasis...
  78. ncbi Assessing exposure to allied ground troops in the Vietnam War: a quantitative evaluation of the Stellman Exposure Opportunity Index model
    Michael E Ginevan
    M E Ginevan and Associates, 307 Hamilton Ave, Silver Spring, MD 20901, United States
    Chemosphere 75:1512-8. 2009
    ....
  79. pmc Integration of genome-wide computation DRE search, AhR ChIP-chip and gene expression analyses of TCDD-elicited responses in the mouse liver
    Edward Dere
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA
    BMC Genomics 12:365. 2011
    ..Integration of TCDD-induced genome-wide AhR enrichment, differential gene expression and computational dioxin response element (DRE) analyses further elucidate the hepatic AhR regulatory network...
  80. ncbi Primary structure and inducibility by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) of aryl hydrocarbon receptor repressor in a TCDD-sensitive and a TCDD-resistant rat strain
    Merja Korkalainen
    National Public Health Institute, Department of Environmental Health, P O Box 95, FIN 70701 Kuopio, Finland
    Biochem Biophys Res Commun 315:123-31. 2004
    ..However, simultaneous measurement of CYP1A1 mRNA reinforced the view that AHRR is an important determinant of tissue-specific responsiveness to TCDD...
  81. pmc The effects of an in utero exposure to 2,3,7,8-tetrachloro-dibenzo-p-dioxin on male reproductive function: identification of Ccl5 as a potential marker
    D Rebourcet
    INSERM, U870, Oullins, Cedex, France
    Int J Androl 33:413-24. 2010
    ..In conclusion, we demonstrated a decrease in Ccl5/Rantes RNA levels and a transitory decline in sperm reserves in the testes of rats of TCDD-dosed dams...
  82. ncbi Impaired cued delayed alternation behavior in adult rat offspring following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on gestation day 15
    Vincent P Markowski
    Department of Psychology, University of Southern Maine, Portland, ME 04104 9300, USA
    Neurotoxicol Teratol 24:209-18. 2002
    ....
  83. pmc Developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters postnatal T cell phenotypes and T cell function and exacerbates autoimmune lupus in 24-week-old SNF1 mice
    Amjad Mustafa
    Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University Blacksburg, Virginia, USA
    Birth Defects Res A Clin Mol Teratol 85:828-36. 2009
    ..Untreated, more than 95% of female SWR x NZB: F(1) (SNF(1)) mice spontaneously develop a fatal lupus-like glomerulonephritis by 8 months-of-age, while disease onset in males is much slower...
  84. pmc Identification of the aryl hydrocarbon receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin and of nicotinamide as a corrective agent for this effect
    Silvia Diani-Moore
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Biol Chem 285:38801-10. 2010
    ..The results reveal that TiPARP can mediate a TCDD effect, that the AHR is linked to PGC1α function and stability and that NAM has novel AHR antagonist activity...
  85. pmc Aryl hydrocarbon receptor nuclear translocator in hepatocytes is required for aryl hydrocarbon receptor-mediated adaptive and toxic responses in liver
    Manabu Nukaya
    McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    Toxicol Sci 118:554-63. 2010
    ....
  86. ncbi 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces suppressor of cytokine signaling 2 in murine B cells
    Darrell R Boverhof
    Department of Biochemistry and Molecular Biology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824 1319, USA
    Mol Pharmacol 66:1662-70. 2004
    ..Promoter activity was also dependent on a functional AhR signaling pathway. These results indicate that Socs2 is a primary TCDD-inducible gene that may represent a novel mechanism by which TCDD elicits its immunosuppressive effects...
  87. pmc A novel nonconsensus xenobiotic response element capable of mediating aryl hydrocarbon receptor-dependent gene expression
    Gengming Huang
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555 0654, USA
    Mol Pharmacol 81:338-47. 2012
    ....
  88. ncbi Induction of oxidative stress in rat epididymal sperm after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    C Latchoumycandane
    School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
    Arch Toxicol 76:113-8. 2002
    ..In conclusion, the adverse effect on male reproduction in TCDD-treated rats may be due to the induction of oxidative stress in sperm...
  89. ncbi 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced change in intestinal function and pathology: evidence for the involvement of arylhydrocarbon receptor-mediated alteration of glucose transportation
    Takumi Ishida
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Toxicol Appl Pharmacol 205:89-97. 2005
    ..The data provided here also suggest that AhR is involved in the mechanism of SGLT1 induction...
  90. pmc Serum dioxin concentrations and age at menopause
    Brenda Eskenazi
    School of Public Health, University of California at Berkeley, Berkeley, California 94720 7360, USA
    Environ Health Perspect 113:858-62. 2005
    ..04). These results suggest a nonmonotonic dose-related association with increasing risk of earlier menopause up to about 100 ppt TCDD, but not above...
  91. ncbi Comparative contribution of the aryl hydrocarbon receptor gene to perinatal stage development and dioxin-induced toxicity between the urogenital complex and testis in the mouse
    Seiichiroh Ohsako
    Division of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Biol Reprod 82:636-43. 2010
    ..Further, the Ahr gene, analyzed in this study, does not significantly contribute to testicular function during perinatal and immature stages, and the developing mouse testis appears to be quite resistant to TCDD exposure...
  92. ncbi Transient increase in micronucleus frequency and DNA effects in the comet assay in two patients after intoxication with 2,3,7,8-tetrachlorodibenzo- p-dioxin
    Eva Valic
    Clinical Department of Occupational Medicine, University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
    Int Arch Occup Environ Health 77:301-6. 2004
    ..The genotoxic effects in two patients with 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) intoxication were measured; an association with the workplace was suspected...
  93. pmc The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology
    Manabu Nukaya
    McArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 106:4923-8. 2009
    ..Given the 100% penetrance of patent DV in Ahr null mice, these results indicate that Cyp1a1 and Cyp1a2 do not play a dominant role in AHR-mediated vascular development...
  94. ncbi Neonatal exposure to low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin causes autoimmunity due to the disruption of T cell tolerance
    Naozumi Ishimaru
    Department of Oral Molecular Pathology, Institute of Health Biosciences, University of Tokushima Graduate School, Kuramotocho, Tokushima, Japan
    J Immunol 182:6576-86. 2009
    ..These results suggest that TCDD/aryl hydrocarbon receptor signaling in the neonatal thymus plays an important role in the early thymic differentiation related to autoimmunity...
  95. pmc Detection of the TCDD binding-fingerprint within the Ah receptor ligand binding domain by structurally driven mutagenesis and functional analysis
    Alessandro Pandini
    Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Biochemistry 48:5972-83. 2009
    ....
  96. ncbi In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,4,7,8-pentachlorodibenzofuran reduces growth and disrupts reproductive parameters in female rats
    Travis B Salisbury
    Department of Biological Sciences, Kent State University, Kent, Ohio 44242, USA
    Biol Reprod 66:1621-6. 2002
    ..The numbers of smaller follicles (both antral and small antral) were not different. Serum estradiol was significantly lower in TCDD-exposed animals 48 h after eCG stimulation...
  97. pmc Dioxin and diabetes mellitus: an analysis of the combined NIOSH and Ranch Hand data
    K Steenland
    National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA
    Occup Environ Med 58:641-8. 2001
    ..To reanalyze in a similar manner the two principal studies of TCDD (tetrachlorodibenzo-p-dioxin) and diabetes in an attempt to reconcile disparate results...
  98. ncbi Dioxin concentrations in breast milk of Vietnamese nursing mothers: a survey four decades after the herbicide spraying
    Pham The Tai
    Department of Epidemiology and Public Health, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Environ Sci Technol 45:6625-32. 2011
    ..84 pg/g lipid for multiparae, respectively, with significant differences in the values among the three areas. In the hot spots, dioxin levels were highly correlated with the residency of mothers after adjustment for their age and parity...
  99. pmc Dioxin silences gonadotropin expression in perinatal pups by inducing histone deacetylases: a new insight into the mechanism for the imprinting of sexual immaturity by dioxin
    Tomoki Takeda
    Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    J Biol Chem 287:18440-50. 2012
    ..These results strongly suggest that the increased deacetylation of histone owing to HDAC induction plays a critical role in the TCDD-induced reduction in LHβ in the fetal pituitary...
  100. ncbi Role of CYP1A2 in hepatic sequestration of dioxin: studies using CYP1A2 knock-out mice
    J J Diliberto
    Experimental Toxicology Division, National Health Effects and Environmental Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Biochem Biophys Res Commun 236:431-3. 1997
    ..As demonstrated by the liver-to-adipose tissue (L/F) concentration ratios, there was no hepatic sequestering of TCDD and 4-PeCDF in the transgenic knock-out mice...
  101. ncbi Three-generation experiment showed female C57BL/6J mice drink drainage canal water containing low level of TCDD-like activity causing high pup mortality
    Li Huang
    Experimental Animal Research center, Guangzhou Medical College, Yuexiu District, Guangzhou, China
    J Toxicol Sci 36:713-24. 2011
    ..Considering this canals are open directly to Pearl River, whether these effects could be caused in human reproduction and development warrants further study...

Research Grants66

  1. METABOLISM OF ENVIRONMENTAL CONTAMINANTS BY FISH
    JOHN LECH; Fiscal Year: 1992
    ..model inducers to be studied include 3- methylcholanthrene (3-MC), beta-naphthoflavone (BNF), 2,3,7,8- tetrachlorodibenzodioxin (TCDD) and 2,3,7,8-tetra- chlorodibenzofuran (TCDF)...
  2. TOXICOLOGY OF ENVIRONMENT CONTAMINANTS
    Stephen Safe; Fiscal Year: 2007
    ..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
  3. Inhibition of Pancreatic Cancer by New PPARgamma Agonis*
    Stephen Safe; Fiscal Year: 2008
    ..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
  4. ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXES
    Stephen Safe; Fiscal Year: 2002
    ..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
  5. Colon Cancer Inhibition by a Class of PPARgamma Agonists
    Stephen Safe; Fiscal Year: 2009
    ..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
  6. Coactivation of Estrogen Receptor alpha/Sp1
    Stephen Safe; Fiscal Year: 2006
    ..abstract_text> ..
  7. ALKYL PCDFS--INHIBITION OF MAMMARY CANCER
    Stephen Safe; Fiscal Year: 2001
    ..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
  8. Mechanisms of Growth Factor-Estrogen Receptor Crosstalk
    Stephen Safe; Fiscal Year: 2006
    ..abstract_text> ..
  9. 2,3,7,8,--TCDD Effects on the Estrogenic Responses
    Stephen Safe; Fiscal Year: 2006
    ..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
  10. RECEPTOR MEDIATED OXIDATIVE STRESS
    HOWARD SHERTZER; Fiscal Year: 2003
    ..These studies will improve our understanding of how PHAHs such as TCDD generate oxidative stress and mutagenesis, leading to better models for risk assessment and novel strategies for intervention in PHAH-mediated toxicity. ..
  11. Glutathione in Environmental Toxicity and Disease
    HOWARD SHERTZER; Fiscal Year: 2007
    ..Our proposed research should therefore help focus future genotype-phenotype association studies between the appropriate DNA variant sites in the GCLC and GCLM genes and disease. ..
  12. Long Term Toxicity of Di- and Tri-Chloroacetate
    Ezdihar Hassoun; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  13. MECHANISM OF ESTROGENICITY OF DDT ANALOGS IN MCG-7 CELLS
    Fumio Matsumura; Fiscal Year: 2001
    ..The PI finally will address the fundamental question of whether c-Neu activation serves as a major gateway in addition to the estrogen receptor for xenobiotics to cause truly estrogenic cellular responses or not. ..
  14. Breast stem cell analysis in random periareolar fine needle aspirates from high r
    BRIAN PETROFF; Fiscal Year: 2008
    ..Overall, this work has the potential to improve our understanding of breast stem cells and cancer risk and refine breast cancer prevention through a novel stem cell-targeted approach. [unreadable] [unreadable] [unreadable]..
  15. Reducing pesticide exposures to farmworker children.
    Brenda Eskenazi; Fiscal Year: 2005
    ....
  16. Aryl hydrocarbon receptor pathway and reproductive aging
    BRIAN PETROFF; Fiscal Year: 2006
    ..abstract_text> ..
  17. AhR and reproductive aging
    BRIAN PETROFF; Fiscal Year: 2008
    ..This project will provide crucial knowledge for the identification and prevention of infertility and birth defects due to the AhR pathway in older mothers. [unreadable] [unreadable] [unreadable]..
  18. PBDEs, DDT and Neurodevelopment in School-Aged Mexican-American Children
    Brenda Eskenazi; Fiscal Year: 2010
    ....
  19. Genetic damage in the sperm and blood of workers exposed to benzene
    Brenda Eskenazi; Fiscal Year: 2008
    ..Lastly, this study is one of the first to investigate the relative sensitivities of sperm and blood cells to chromosomal defects induced by benzene. [unreadable] [unreadable] [unreadable]..
  20. Endocrine Disruptors and Neurodevelopmental Outcomes
    Brenda Eskenazi; Fiscal Year: 2004
    ..This study will provide the first data on exposure and health effects of ED pesticides in a highly exposed population, complete the exposure profile of CHAMACOS children, and target interventions to reduce child exposures. ..
  21. Experimental Endometriosis in Mice After Adoptive Transfer of Human Immune Cells
    KAYLON BRUNER TRAN; Fiscal Year: 2008
    ..With this information, better treatment strategies that target immune cell factors could begin to be developed. [unreadable] [unreadable] [unreadable]..
  22. Regulation of cyp1a1 by Ah Receptor and NFkB Interaction
    Yanan Tian; Fiscal Year: 2009
    ..The proposed studies will help us gain mechanistic understandings of the functions of AhR and NF-kB in normal physiology as well as pathogenesis induced by dioxin and related compounds. ..
  23. Training Program in Molecular and Cellular Toxicology
    John Reiners; Fiscal Year: 2008
    ..It is envisioned that students with such training will be better equipped to pursue postdoctoral research at major research laboratories throughout the United States. ..
  24. Prenatal TCDD and postnatal autoimmune disease
    Steven Holladay; Fiscal Year: 2007
    ..The collective experiments are designed to detect alterations in fetal immune development caused by TCDD that underlie the worsened postnatal (postpubertal) autoimmune disease caused by this chemical. ..
  25. SCREENS TO IDENTIFY GAIN OF FUNCTION AH RECEPTOR MUTANTS INVOLVED IN DEGRADATION
    RICHARD POLLENZ; Fiscal Year: 2008
    ..e. steroid hormone receptors). [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  26. IMPACT OF AH RECEPTOR DEGRADATION IN VIVO AND IN VITRO
    RICHARD POLLENZ; Fiscal Year: 2005
    ..abstract_text> ..
  27. Columbia-GHI Consortium for Claims-Based Cancer Studies
    STEVEN STELLMAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  28. Roles of CYP1 & 19 in Fundulus Steroids & PAH Metabolism
    Kristine Willett; Fiscal Year: 2009
    ..This research will further define the utility of Fundulus as a model organism for studying PAH-associated toxicities and in the development of human CYP19 or CYP1 B-related therapeutics. ..
  29. Role of Retroelements in Environmental Atherogenesis
    Kenneth S Ramos; Fiscal Year: 2010
    ..Studies are proposed in this application to study the role of virus-like sequences in the onset and progression of environmentally-induced atherosclerosis in experimental systems. ..
  30. Perfluorooctane sulfonate (PFOS) Affects Immunity through PPAR-alpha.
    Margie Peden Adams; Fiscal Year: 2007
    ..The unimmunized and immunized experiments will be conducted to control for possible differences in response related to lymphocyte activation from the immunization. [unreadable] [unreadable] [unreadable]..
  31. Analysis and Effect of Persistent Ah Receptor Activation
    Michael Denison; Fiscal Year: 2008
    ..abstract_text> ..
  32. Function and Regulation of Human Cytochrome P4502S1
    Oliver Hankinson; Fiscal Year: 2010
    ....
  33. Neurobehavioral Teratology Society: Symposium on Pesticides and Metals
    Susan Schantz; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  34. CARCINOGEN ACTIVATION AND SCREENING IN VARIANT CELLS
    Oliver Hankinson; Fiscal Year: 2010
    ..abstract_text> ..
  35. Carcinogenicity of Estrogens
    DAVID SPINK; Fiscal Year: 2009
    ..These studies may elucidate roles of estrogen in the regulation of Ah responsiveness, CYP1 expression, and carcinogen bioactivation that may lead to novel breast cancer chemoprevention strategies. ..
  36. Cardiotoxicity Drug Screening Using Zebrafish
    Chuenlei Parng; Fiscal Year: 2004
    ..Zebrafish drug screens can serve as an intermediate step between cell-based and mammalian testing, streamlining the drug development timeline. ..
  37. DIETARY LIPIDS AND EXPERIMENTAL IGA NEPHROPATHY
    James Pestka; Fiscal Year: 2009
    ..abstract_text> ..
  38. Exploring epigenetic mechanisms of developmental immunology
    B Paige Lawrence; Fiscal Year: 2007
    ..Findings from these studies will improve our understanding of the mechanisms that underlie the fetal programming of adult diseases of the immune system. ..
  39. Clinical and Translational Science Institute in Arkansas
    PHILIP KERN; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  40. Developmental arsenic exposure produces cognitive impairments
    VINCENT MARKOWSKI; Fiscal Year: 2006
    ..The proposed research is designed to determine how inorganic arsenic impairs cognitive function following gestational exposure. [unreadable] [unreadable] [unreadable]..
  41. Zebrafish Screen for Neuroprotective Anti-oxidants
    Chuenlei Parng; Fiscal Year: 2005
    ..Assessment of drug effects in a convenient vertebrate model, prior to evaluation in a complex system, such as mouse, can potentially streamline the drug development process and dramatically reduce costs. ..
  42. Ah Receptor and Cardiac Adrenergic Signaling
    REBECCA SOMMER; Fiscal Year: 2005
    ..Completion of these studies will provide important mechanistic data on the cardiovascular toxicology of TCDD and provide insight into the normal role of the AhR in the developing heart. ..
  43. 2004 Mechanisms of Toxicity Gordon Research Conference
    Kenneth Ramos; Fiscal Year: 2004
    ..Thus, the 2004 conference is poised to continue its growth as the single leading small conference in toxicology. ..
  44. ASSAY FOR DETERMINING DRUG TOXICITY
    Chuenlei Parng; Fiscal Year: 2004
    ..abstract_text> ..
  45. MECHANISMS OF TCDD PULMONARY IMMUNOTOXICITY
    B Lawrence; Fiscal Year: 2004
    ....
  46. OSTEOPONTIN AND OXIDATIVE STRESS IN ATHEROGENESIS
    Kenneth Ramos; Fiscal Year: 2003
    ..These studies are important in view of the increasing scrutiny of the role of oxidative injury in the onset and progression of atherogenesis. ..
  47. Heme Oxygenase-Regulation, Function&Clinical Application
    MAHIN MAINES; Fiscal Year: 2003
    ....
  48. COLLAGENASE REMOVAL IN OSTEOARTHRITIS
    Nicola Partridge; Fiscal Year: 2002
    ..This work will offer insight into the basic pathophysiology of osteoarthritis and will be the basis for a new treatment option as well as determining the mechanisms of that treatment. ..
  49. ENDOTOXIN AND SUSCEPTIBILITY TO TRICHOTHECENE MYCOTOXINS
    James Pestka; Fiscal Year: 2002
    ..Over the long term, this research will provide insight into adverse immunologic consequences that may occur in LPS-exposed individuals who are exposed to environmental toxicants." ..
  50. MECHANISM OF INDUCTION OF OLFACTORY TUMORS BY ALACHLOR
    Mary Beth Genter; Fiscal Year: 2002
    ....
  51. MOLECULAR MECHANISMS OF CHEMICAL ATHEROGENESIS
    Kenneth Ramos; Fiscal Year: 2005
    ..These studies will enable us to define the role of ARE/EpRE binding proteins in oxidant-induced atherogenesis and identify critical transacting factors involved in the atherogenic response to environmental injury. ..
  52. DNA Damage as Women Age: Implications for Breast Cancer
    DONALD MALINS; Fiscal Year: 2005
    ....
  53. LEARNING THROUGH ENVIRONMENTAL HEALTH SCIENCE SCENARIOS
    Nancy Kerkvliet; Fiscal Year: 2006
    ..As a result of this project, it is hoped that students will demonstrate improved academic performance, decision-making skills, and attitudes toward science and school, as well as increased knowledge of environmental health issues. ..
  54. Akt activation sustains silica induced inflammation
    CELINE BEAMER; Fiscal Year: 2006
    ..abstract_text> ..
  55. 2-METHOXYESTRADIOL & HORMONAL CANCER
    Bao Ting Zhu; Fiscal Year: 2006
    ..The results will also provide novel mechanistic understanding for the biological actions of 2-MeO-E2. ..
  56. ARNT:Roles in Tumor Induction and Growth, and Toxicity.
    Oliver Hankinson; Fiscal Year: 2006
    ..abstract_text> ..
  57. Elucidation of the hr-dependent pathway of hair growth
    Andrey Panteleyev; Fiscal Year: 2005
    ..Thus, the experiments outlined in this proposal are designed to dissect the cellular and molecular mechanisms of hair follicle catagen transformation using the hairless phenotype as an experimental model. ..
  58. "Ligand Independent" endocrine disruption by pesticides
    Patrick Wong; Fiscal Year: 2005
    ..abstract_text> ..
  59. FETAL ALCOHOL SYNDROME: GENETIC STUDIES IN ZEBRAFISH
    MICHAEL CARVAN; Fiscal Year: 2002
    ..abstract_text> ..
  60. TCDD Impairs Prostate Development: Cyp2c39 & Retinoids
    CHAD VEZINA; Fiscal Year: 2008
    ..abstract_text> ..
  61. Asbestos Disease Among Household Contacts of Vermiculite Workers
    Alfred Franzblau; Fiscal Year: 2006
    ..In addition, tests for trend will be conducted to[unreadable] determine significant increasing pleural changes in household contacts by increasing indices of exposure. ..
  62. Xenobiotic Receptors in toxicology and Carcinogenesis
    Gary Perdew; Fiscal Year: 2002
    ..A detailed web site has been established: http://www. bmb. psu. edu/symposium/. ..
  63. Cloning of Ah receptor bound regulatory DNA
    Gary Perdew; Fiscal Year: 2005
    ..This method should in the future be utilized in biology for a wide range of mechanistic studies. ..
  64. Biochemical analysis of the human vs. mouse Ah receptor
    Gary Perdew; Fiscal Year: 2007
    ..Collectively, these studies will establish the level of divergence in human vs. mouse AhR function and should allow a better assessment of the significance of human exposure to TCDD. [unreadable] [unreadable] [unreadable]..