Genomes and Genes
Summary: A chemical by-product that results from burning or incinerating chlorinated industrial chemicals and other hydrocarbons. This compound is considered an environmental toxin, and may pose reproductive, as well as, other health risks for animals and humans.
Publications323 found, 100 shown here
- Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptorFrancisco J Quintana
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nature 453:65-71. 2008..Thus, AHR regulates both T(reg) and T(H)17 cell differentiation in a ligand-specific fashion, constituting a unique target for therapeutic immunomodulation...
- Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptorJ Mimura
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai, Japan
Genes Cells 2:645-54. 1997..In contrast to the role of AhR in the regulatory mechanism of xenobiotic-metabolizing enzymes, there is no direct proof that the AhR is involved in the teratogenic effects of TCDD...
- Identification of a novel mechanism of regulation of Ah (dioxin) receptor functionJ Mimura
Department of Chemistry, Graduate School of Science, Tohoku University, Aoba ku, Sendai 980 8578, Japan
Genes Dev 13:20-5. 1999..Thus, AhR and AhRR form a regulatory circuit in the xenobiotic signal transduction pathway and provide a novel mechanism of regulation of AhR function that may determine tissue-specific sensitivity to environmental pollutants...
- Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicityP M Fernandez-Salguero
Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Toxicol Appl Pharmacol 140:173-9. 1996..The mechanism(s) responsible for these apparently receptor-independent processes remain unclear but may involve novel, alternative pathways for TCDD-induced toxicity...
- Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteriesNathalie Tijet
Department of Pharmacology, Medical Sciences Building, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Mol Pharmacol 69:140-53. 2006..Overall, our study identifies a wide range of genes that depend on the AHR, either for constitutive expression or for response to TCDD...
- 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identification and measurement of TCDD metabolitesO Sorg
Dermato Toxicology, Swiss Centre for Applied Human Toxicology, and Department of Dermatology, University Hospital, Geneva, Switzerland
Lancet 374:1179-85. 2009..We monitored TCDD, its form, distribution, and elimination in Victor Yushchenko after he presented with severe poisoning...
- Modulation of the chemokines KC and MCP-1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in miceChristoph Franz Adam Vogel
Department of Environmental Toxicology, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
Arch Biochem Biophys 461:169-75. 2007....
- Dioxin exposure and cancer risk in the Seveso Women's Health StudyMarcella Warner
Center for Environmental Research and Children s Health, School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
Environ Health Perspect 119:1700-5. 2011..The International Agency for Research on Cancer classified TCDD as a known human carcinogen, based on predominantly male occupational studies of increased mortality from all cancers combined...
- Dioxin and immune regulation: emerging role of aryl hydrocarbon receptor in the generation of regulatory T cellsNikki B Marshall
Department of Microbiology, Environmental Health Sciences Center, Oregon State University, Corvallis, OR 97331, USA
Ann N Y Acad Sci 1183:25-37. 2010..Although it is not yet clear how activation of AHR by TCDD induces Tregs, there is a potential therapeutic role for alternative AHR ligands in the treatment of immune-mediated disorders...
- AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell linesSarah L Hockley
Section of Molecular Carcinogenesis, The Institute of Cancer Research, Surrey, UK
Chem Res Toxicol 20:1797-810. 2007..Promoter analysis identified candidate genes for direct transcriptional regulation by either AHR or p53. These analyses have further dissected and characterized the complex cellular response to BaP...
- Comparative analysis of AhR-mediated TCDD-elicited gene expression in human liver adult stem cellsSuntae Kim
Department of Biochemistry and Molecular Biology, 501 Biochemistry Building, Wilson Road, East Lansing, MI 48824 1319, USA
Toxicol Sci 112:229-44. 2009..Although some common pathways are affected, the results suggest that TCDD elicits species- and model-specific gene expression profiles...
- A geographic information system for characterizing exposure to Agent Orange and other herbicides in VietnamJeanne Mager Stellman
Department of Health Policy and Management, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Environ Health Perspect 111:321-8. 2003..To facilitate widespread use of the GIS, a user-friendly software package was developed to permit researchers to assign exposure opportunity indexes to troops, locations, or individuals...
- Aryl hydrocarbon receptor (AhR) agonists suppress interleukin-6 expression by bone marrow stromal cells: an immunotoxicology studyBrenda A Jensen
Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
Environ Health 2:16. 2003..Here, we extend these studies to evaluate the potential for two prototypic AhR agonists, 7,12-dimethylbenz [a]anthracene (DMBA) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), to alter stromal cell cytokine responses...
- Aryl hydrocarbon receptor activation reduces dendritic cell function during influenza virus infectionGuang Bi Jin
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Toxicol Sci 116:514-22. 2010..Moreover, our results reinforce the idea that environmental signals and AhR ligands may contribute to differential susceptibilities and responses to respiratory infection...
- Functional role of AhR in the expression of toxic effects by TCDDJunsei Mimura
Department of Biomolecular Science, Graduate School of Life Science, Tohoku University, Aoba ku, 980 8578, Sendai, Japan
Biochim Biophys Acta 1619:263-8. 2003..We summarize the present knowledge about functional role of AhR in TCDD-induced biological effects...
- Health status of Army Chemical Corps Vietnam veterans who sprayed defoliant in VietnamHan K Kang
Veterans Health Administration, Department of Veterans Affairs, Washington, District of Columbia 20420, USA
Am J Ind Med 49:875-84. 2006..This study examined the long-term health effects associated with herbicide exposure among these Vietnam veterans...
- In vivo-in vitro toxicogenomic comparison of TCDD-elicited gene expression in Hepa1c1c7 mouse hepatoma cells and C57BL/6 hepatic tissueEdward Dere
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing MI 48824 1319, USA
BMC Genomics 7:80. 2006....
- Diabetes and cancer in veterans of Operation Ranch Hand after adjustment for calendar period, days of spraying, and time spent in Southeast AsiaJoel E Michalek
Department of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio, Texas 78229, USA
J Occup Environ Med 50:330-40. 2008..The Air Force Health Study was launched in 1980 as part of a Federal effort to resolve the Agent Orange issue...
- Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and developmentJ V Schmidt
Department of Molecular Pharmacology, Northwestern University Medical School, Chicago, IL 60611, USA
Proc Natl Acad Sci U S A 93:6731-6. 1996....
- Induction of cytochrome P4501A1J P Whitlock
Department of Molecular Pharmacology, Stanford University School of Medicine, California 94305 5332, USA
Annu Rev Pharmacol Toxicol 39:103-25. 1999....
- Aryl hydrocarbon receptor activation by TCDD reduces inflammation associated with Crohn's diseaseJenna M Benson
Department of Biomedical and Pharmaceutical Sciences, Center for Environmental Health Sciences, University of Montana, Missoula, Montana 59812, USA
Toxicol Sci 120:68-78. 2011..Ultimately, this work may lead to the development of more effective therapeutics for the treatment of Crohn's disease...
- Comparative analysis of dioxin response elements in human, mouse and rat genomic sequencesY V Sun
Department of Biochemistry and Molecular Biology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
Nucleic Acids Res 32:4512-23. 2004..These results suggest that AhR-mediated gene expression may not be well conserved across species, which could have significant implications in human risk assessment...
- Ah receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functionsKarl Walter Bock
Department of Toxicology, Institute of Pharmacology and Toxicology, University of Tubingen, Tubingen, Germany
Biochem Pharmacol 72:393-404. 2006..Though important issues remain unresolved, the commentary is intended to stimulate efforts to understand dioxin-mediated toxic responses with emphasis on carcinogenesis in comparison with AhR-mediated physiologic functions...
- Suppression mechanisms of flavonoids on aryl hydrocarbon receptor-mediated signal transductionRie Mukai
Department of Agrobioscience, School of Agricultural Science, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
Arch Biochem Biophys 501:134-41. 2010..The inhibition of MEK/ERK phosphorylation is one of the mechanisms by which flavanones and catechins suppress the AhR-mediated signal transduction in Hepa-1c1c7 cells...
- Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipogenic differentiation and insulin-induced glucose uptake in 3T3-L1 cellsHsin Fen Hsu
Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan
J Hazard Mater 182:649-55. 2010..These results provide in vitro evidence of TCDD's effects on fat cell metabolism, suggesting dioxin exposure in development of insulin resistance and type II diabetes...
- Severe 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) intoxication: kinetics and trials to enhance elimination in two patientsAlexandra Geusau
Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases, University of Vienna, Medical School, Wahringer Gurtel 18 20, 1090 Vienna, Austria
Arch Toxicol 76:316-25. 2002..When employed twice a week, the amount of TCDD excreted by this method was comparable to fecal excretion. In view of costs and time involved, LDL-apheresis does not seem to be justified for enhancement of TCDD elimination...
- Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin administration and high-fat diet on the body weight and hepatic estrogen metabolism in female C3H/HeN miceBao Ting Zhu
Department of Pharmacology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA
Toxicol Appl Pharmacol 226:107-18. 2008....
- Expression of aryl hydrocarbon receptor repressor in normal human tissues and inducibility by polycyclic aromatic hydrocarbons in human tumor-derived cell linesYuki Tsuchiya
Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, Takara machi 13 1, Kanazawa 920 0934, Japan
Toxicol Sci 72:253-9. 2003..The chemical-specific inducibility of AhRR was also similar to that of the CYP1 family determined in our previous study. These results indicated that AhRR is also induced in chemical- and cell-specific manners...
- Effects of chronic exposure to DDT and TCDD on disease activity in murine systemic lupus erythematosusJ Li
Department of Endocrinology and Metabolism, The First Affiliated Hospital, China Medical University, Shenyang, PR China
Lupus 18:941-9. 2009..TCDD was immunosuppressive to murine SLE. Xenoestrogens may have compound- and tissue-specific effects that require further elucidation in future work...
- Altered protein profile and possible hypoxia in the placenta of 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed ratsRyuta Ishimura
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
Toxicol Appl Pharmacol 185:197-206. 2002..Finally, the results of this study suggested the possibility that the increased incidence of fetal death after exposure to TCDD was due to the placental hypoxia...
- Histological analysis of acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in zebrafishJeanmarie M Zodrow
Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
Aquat Toxicol 66:25-38. 2004..Overall, TCDD exposure in adult zebrafish leads to histopathology similar to that reported in other fish species, and it appears unlikely that the histopathology in these organs completely explains the inhibition of fin regeneration...
- The aryl hydrocarbon receptor displaces p300 from E2F-dependent promoters and represses S phase-specific gene expressionJennifer L Marlowe
Center for Environmental Genetics and the Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
J Biol Chem 279:29013-22. 2004..The AHR seems to act as an environmental checkpoint that senses exposure to environmental toxicants and responds by signaling cell cycle inhibition...
- A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999-2002Duk Hee Lee
Department of Preventive Medicine, School of Medicine, Kyungpook University, 101 Dongin dong, Jung Gu, Daegu, Korea 700 422
Diabetes Care 29:1638-44. 2006..Low-level exposure to some persistent organic pollutants (POPs) has recently become a focus because of their possible link with the risk of diabetes...
- Signaling pathway for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced TNF-alpha production in differentiated THP-1 human macrophagesHyeonjoo Cheon
Department of Biochemistry, Korean Institute of Molecular Medicine and Nutrition, Korea University College of Medicine, Seoul 136 705, Korea
Exp Mol Med 39:524-34. 2007..A signaling pathway is proposed where TCDD induces sequential activation of AhR, EGFR and ERK, leading to the increased expression of TNF-alpha...
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters the differentiation pattern of human keratinocytes in organotypic cultureJ A Loertscher
Department of Pathology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
Toxicol Appl Pharmacol 175:121-9. 2001..This TCDD-induced effect on differentiation-specific proteins results in profound changes in the tissue architecture...
- Deletion of the aryl hydrocarbon receptor enhances the inflammatory response to Leishmania major infectionGuillermo Elizondo
Centro de Investigacion y Estudios Avanzados del Instituto Politecnico Nacional, Departamento de Biologia Celular, Av IPN 2508, San Pedro Zacatenco, C P 07360, Mexico D F, Mexico
Int J Biol Sci 7:1220-9. 2011..This decrease was associated with a reduction in Foxp3 mRNA levels. Finally, the alteration in the cytokine profile results in a better resolution of the L. major infection...
- Cross-species comparisons of transcriptomic alterations in human and rat primary hepatocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxinMichael B Black
The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 127:199-215. 2012..The results provide evidence for divergent cross-species gene expression changes in response to TCDD and are consistent with epidemiological and clinical evidence showing humans to be less sensitive to TCDD-induced hepatotoxicity...
- Inhibition of neovascularization by environmental agentsIrena Ivnitski-Steele
College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Cardiovasc Toxicol 5:215-26. 2005..Thus, additional research also is needed to identify those environmental agents that mediate their toxicity by disrupting neovascularization...
- Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7X Coumoul
, , , France
Cancer Res 61:3942-8. 2001..These results show that xenoestrogens, by altering the ratio of CYP1B1/CYP1A1, could redirect estradiol metabolism in a more toxic pathway in the breast cell line MCF-7...
- TCDD (2,3,7,8-tetrachlorodibenzo-P-dioxin) causes reduction in glucose uptake through glucose transporters on the plasma membrane of the guinea pig adipocyteE Enan
Dept of Environmental Toxicology, University of California, Davis 95620
J Environ Sci Health B 27:495-510. 1992..These findings may contribute to a better understanding of dioxin-induced "wasting syndrome"...
- Altered operant responding for motor reinforcement and the determination of benchmark doses following perinatal exposure to low-level 2,3,7,8-tetrachlorodibenzo-p-dioxinV P Markowski
Department of Psychology, University of Southern Maine, Portland, Maine, USA
Environ Health Perspect 109:621-7. 2001..71 ng/kg with a 95% lower bound of 0.60. These values should be viewed from the perspective of current human body burdens, whose average value, based on TCDD toxic equivalents, has been calculated as 13 ng/kg...
- Controlling viral immuno-inflammatory lesions by modulating aryl hydrocarbon receptor signalingTamara Veiga-Parga
Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, United States of America
PLoS Pathog 7:e1002427. 2011..Since a single TCDD administration given after the disease process had been initiated generated long lasting anti-inflammatory effects, the approach holds promise as a therapeutic means of controlling virus induced inflammatory lesions...
- Maternal exposure to high levels of dioxins in relation to birth weight in women affected by Yusho diseaseKiyomi Tsukimori
Department of Obstetrics, Fukuoka Children s Hospital, Japan
Environ Int 38:79-86. 2012..In Japan in 1968, an accidental human exposure to rice oil contaminated with PCDDs, PCDFs, and PCBs, led to the development of Yusho disease...
- The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathwaysAlvaro Puga
Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA
Biochem Pharmacol 77:713-22. 2009..Ultimately, the effect of a particular AHR ligand may depend as much on the adaptive interactions that it established with pathways and proteins expressed in a specific cell or tissue as on the toxic responses that it raises...
- In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats disrupts brain sexual differentiationMasahiko Ikeda
University of Shizuoka, Graduate School of Nutritional and Environmental Sciences, Japan
Toxicol Appl Pharmacol 205:98-105. 2005....
- Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomasJ T Buters
National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 96:1977-82. 1999....
- Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 miceDarrell R Boverhof
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
Toxicol Sci 94:398-416. 2006....
- The transcription factor aryl hydrocarbon receptor nuclear translocator functions as an estrogen receptor beta-selective coactivator, and its recruitment to alternative pathways mediates antiestrogenic effects of dioxinJoëlle Rüegg
Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden
Mol Endocrinol 22:304-16. 2008..Moreover, we show for the first time that the inhibitory effects of dioxin are more pronounced on ERbeta than on ERalpha...
- Identification of functional domains of the aryl hydrocarbon receptorB N Fukunaga
Department of Pathology and Laboratory Medicine, University of California, Los Angeles 90095 1786, USA
J Biol Chem 270:29270-8. 1995....
- Prevalence of metabolic syndrome associated with body burden levels of dioxin and related compounds among Japan's general populationHirokazu Uemura
Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
Environ Health Perspect 117:568-73. 2009..Environmental exposure to some persistent organic pollutants has been reported to be associated with a metabolic syndrome in the U.S. population...
- CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptorBin Zhao
Department of Environmental Toxicology, University of California, Davis, California 95616 8588, USA
Toxicol Sci 117:393-403. 2010....
- Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylaseA Poland
J Biol Chem 251:4936-46. 1976....
- Activation of aryl hydrocarbon receptor by TCDD prevents diabetes in NOD mice and increases Foxp3+ T cells in pancreatic lymph nodesNancy I Kerkvliet
Oregon State University, Department of Microbiology, Corvallis, OR 97331, USA
Immunotherapy 1:539-47. 2009..Taken together, the data suggest that AHR activation by TCDD-like ligands may represent a novel avenue for treatment of immune-mediated diseases...
- RelB, a new partner of aryl hydrocarbon receptor-mediated transcriptionChristoph F A Vogel
Department of Environmental Toxicology, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
Mol Endocrinol 21:2941-55. 2007..The interaction of RelB with AhR signaling, and AhR with NF-kappaB RelB signaling pathways represent a new mechanism of cross talk between the two transcription factors...
- Dioxin- and POP-contaminated sites--contemporary and future relevance and challenges: overview on background, aims and scope of the seriesRoland Weber
POPs Environmental Consulting, Ulmenstrasse 3, 73035 Göppingen, Germany
Environ Sci Pollut Res Int 15:363-93. 2008..It also details the various strategies used to assess these historical legacies of contamination and the concepts developed, or which are under development, to effect their remediation...
- The extent and patterns of usage of Agent Orange and other herbicides in VietnamJeanne Mager Stellman
Department of Health Policy and Management, Mailman School of Public Health, Columbia University, 600 West 168th Street, New York, New York 10032, USA
Nature 422:681-7. 2003..Our identification of specific military herbicide targets has led to a more coherent understanding of spraying. Common errors in earlier interpretations of the spray data are also discussed...
- Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDD-Mediated hepatotoxicityDarrell R Boverhof
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing Michigan 48824 1319, USA
Toxicol Sci 85:1048-63. 2005..Collectively, the data support a proposed mechanism for TCDD-mediated hepatotoxicity, including fatty liver, which involves mobilization of peripheral fat and inappropriate increases in hepatic uptake of fatty acids...
- Liver tumor-promoting activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in TCDD-sensitive and TCDD-resistant rat strainsM Viluksela
Laboratory of Toxicology, National Public Health Institute, Kuopio, Finland
Cancer Res 60:6911-20. 2000..Understanding the role of transactivation domain of the aryl hydrocarbon receptor in carcinogenesis is therefore likely to improve dioxin risk assessment...
- Cell death and impairment of glucose-stimulated insulin secretion induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the beta-cell line INS-1ESimona Piaggi
Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, Sezione di Patologia Generale, Pisa, Italy
Toxicol Appl Pharmacol 220:333-40. 2007..On the basis of this latter observation we suggest that pancreatic beta-cells could be considered a specific and sensitive target for dioxin toxicity...
- Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor alpha to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promotersJason Matthews
Department of Biosciences at Novum, Karolinska Institutet, Novum 14157, Sweden
Mol Cell Biol 25:5317-28. 2005..Our data suggest that ERalpha acts as a coregulator of AhR-mediated transcriptional activation and that the recruitment of ERalpha by AhR represents a novel mechanism AhR-ERalpha cross talk...
- Neurodevelopmental defects in zebrafish (Danio rerio) at environmentally relevant dioxin (TCDD) concentrationsAdrian Hill
Laboratory for Environmental Gene Regulation, School of Biological Sciences, Biosciences Building, University of Liverpool, Crown Street, Liverpool Merseyside L69 7ZB, United Kingdom
Toxicol Sci 76:392-9. 2003..This disruption of neuronal development provides the basis for understanding the neurotoxic effects of these compounds...
- Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson RiverIsaac Wirgin
Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
Science 331:1322-5. 2011..This mechanistic basis of resistance in a vertebrate population provides evidence of evolutionary change due to selective pressure at a single locus...
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin activation of the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator pathway causes developmental toxicity through a CYP1A-independent mechanism in zebrafishSara A Carney
Molecular and Environmental Toxicology Center, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705, USA
Mol Pharmacol 66:512-21. 2004..This suggests an alternative model in which TCDD-activated AHR/ARNT disrupts the normal process of growth and development by altering programs of gene expression or function...
- Aryl hydrocarbon receptor 2 mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin developmental toxicity in zebrafishAmy L Prasch
Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin 53726, USA
Toxicol Sci 76:138-50. 2003..Most strikingly, zfahr2 morphants exposed to TCDD never developed edema. Taken together, these results demonstrate that zfAHR2 mediates several endpoints of TCDD developmental toxicity in zebrafish...
- Impact of Agent Orange exposure among Korean Vietnam veteransJoung Soon Kim
Department of Epidemiology, School of Public Health, Seoul National University, 28 Yunkeun dong, Chongno Ku, Seoul 110 799, Republic of Korea
Ind Health 41:149-57. 2003..01), valvular heart disease (p < 0.01), and retinopathy (p < 0.01). We conclude that exposure to Agent Orange is associated with various health impacts in Korean Vietnam veterans...
- Cloning of a factor required for activity of the Ah (dioxin) receptorE C Hoffman
Department of Pathology, University of California, Los Angeles 90024
Science 252:954-8. 1991..Another segment of the protein shows conformity to the consensus sequence for the basic helix-loop-helix motif found in proteins that bind DNA as homodimers or heterodimers...
- Identification of the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole, in cell culture medium, as a factor that controls the background aryl hydrocarbon receptor activityMattias Oberg
Institute of Environmental Medicine, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Toxicol Sci 85:935-43. 2005..These results clearly show that tryptophan derived AhR ligands, which have been suggested to be endogenous AhR ligands, influence the background levels of CYP1A1 activity in cells in culture...
- Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biologyPrabir K Mandal
Department of Biology, University of North Florida, 4567 St John s Bluff Road South, Jacksonville, FL, 32224, USA
J Comp Physiol B 175:221-30. 2005....
- Dioxins and human toxicityNatalija Marinković
Department of Chemistry and Biochemistry, Zagreb University School of Medicine, Salata 3, Zagreb, Croatia
Arh Hig Rada Toksikol 61:445-53. 2010..The most sensitive population to dioxin exposure are the foetuses and infants.A large number of health effects have been documented in the scientific literature, and they all place dioxins among the most toxic chemicals known to man...
- 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs an insulin signaling pathway through the induction of tumor necrosis factor-alpha in adipocytesShin Nishiumi
Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Kobe, Hyogo 650 0017, Japan
Toxicol Sci 115:482-91. 2010....
- An overview of the effects of dioxins and dioxin-like compounds on vertebrates, as documented in human and ecological epidemiologySally S White
National Center for Environmental Assessment, U S Environmental Protection Agency, North Carolina, USA
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 27:197-211. 2009..Given these concerns, prudent public health policy should include the continued reduction of exposures...
- TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F(0)F(1)-ATP synthase and ubiquinoneHoward G Shertzer
Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, P O Box 670056 Cincinnati, OH 45267 0056, USA
Toxicol Appl Pharmacol 217:363-74. 2006..This acts in concert with glutathione to increase membrane potential and reactive oxygen production. The proposed defect in ATP synthase explains both the greater respiratory rates and the lower tissue ATP levels...
- Aryl hydrocarbon receptor expression and activity in cerebellar granule neuroblasts: implications for development and dioxin neurotoxicityMary A Williamson
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Toxicol Sci 83:340-8. 2005..These data suggest that (1) granule neuroblasts are direct targets for developmental AhR-mediated TCDD neurotoxicity and (2) TCDD exposure may disrupt granule cell neurogenesis...
- Carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in experimental modelsStefanie Knerr
Food Chemistry and Environmental Toxicology, University of Kaiserslautern, Kaiserslautern, Germany
Mol Nutr Food Res 50:897-907. 2006..The final aim of these efforts is a more reliable risk assessment for the carcinogenic potency of the class of dioxinlike contaminants in humans...
- Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptorH Reyes
Department of Pathology, University of California, Los Angeles 90024
Science 256:1193-5. 1992..Arnt contains a basic helix-loop-helix motif, which may be responsible for interacting with both the XRE and the ligand-binding subunit...
- Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strainR Pohjanvirta
National Public Health Institute, Department of Environmental Medicine, FIN 70701 Kuopio, Finland
Mol Pharmacol 54:86-93. 1998..These findings suggest that there is a relatively small region in the AhR trans-activation domain that may be capable of providing selectivity to its function...
- Disruption of thyroid hormone homeostasis at weaning of Holtzman rats by lactational but not in utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxinNoriko Nishimura
Endocrine Disruptors and Dioxin Research Project, National Institute for Environmental Studies, Tsukuba 305 8506, Japan
Toxicol Sci 85:607-14. 2005..The present results demonstrate that lactational, but not in utero, exposure to TCDD was responsible for the disruption of thyroid hormone homeostasis...
- Assessing exposure to allied ground troops in the Vietnam War: a quantitative evaluation of the Stellman Exposure Opportunity Index modelMichael E Ginevan
M E Ginevan and Associates, 307 Hamilton Ave, Silver Spring, MD 20901, United States
Chemosphere 75:1512-8. 2009....
- Integration of genome-wide computation DRE search, AhR ChIP-chip and gene expression analyses of TCDD-elicited responses in the mouse liverEdward Dere
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA
BMC Genomics 12:365. 2011..Integration of TCDD-induced genome-wide AhR enrichment, differential gene expression and computational dioxin response element (DRE) analyses further elucidate the hepatic AhR regulatory network...
- Primary structure and inducibility by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) of aryl hydrocarbon receptor repressor in a TCDD-sensitive and a TCDD-resistant rat strainMerja Korkalainen
National Public Health Institute, Department of Environmental Health, P O Box 95, FIN 70701 Kuopio, Finland
Biochem Biophys Res Commun 315:123-31. 2004..However, simultaneous measurement of CYP1A1 mRNA reinforced the view that AHRR is an important determinant of tissue-specific responsiveness to TCDD...
- The effects of an in utero exposure to 2,3,7,8-tetrachloro-dibenzo-p-dioxin on male reproductive function: identification of Ccl5 as a potential markerD Rebourcet
INSERM, U870, Oullins, Cedex, France
Int J Androl 33:413-24. 2010..In conclusion, we demonstrated a decrease in Ccl5/Rantes RNA levels and a transitory decline in sperm reserves in the testes of rats of TCDD-dosed dams...
- Impaired cued delayed alternation behavior in adult rat offspring following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on gestation day 15Vincent P Markowski
Department of Psychology, University of Southern Maine, Portland, ME 04104 9300, USA
Neurotoxicol Teratol 24:209-18. 2002....
- Developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters postnatal T cell phenotypes and T cell function and exacerbates autoimmune lupus in 24-week-old SNF1 miceAmjad Mustafa
Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University Blacksburg, Virginia, USA
Birth Defects Res A Clin Mol Teratol 85:828-36. 2009..Untreated, more than 95% of female SWR x NZB: F(1) (SNF(1)) mice spontaneously develop a fatal lupus-like glomerulonephritis by 8 months-of-age, while disease onset in males is much slower...
- Identification of the aryl hydrocarbon receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin and of nicotinamide as a corrective agent for this effectSilvia Diani-Moore
Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10065, USA
J Biol Chem 285:38801-10. 2010..The results reveal that TiPARP can mediate a TCDD effect, that the AHR is linked to PGC1α function and stability and that NAM has novel AHR antagonist activity...
- Aryl hydrocarbon receptor nuclear translocator in hepatocytes is required for aryl hydrocarbon receptor-mediated adaptive and toxic responses in liverManabu Nukaya
McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
Toxicol Sci 118:554-63. 2010....
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces suppressor of cytokine signaling 2 in murine B cellsDarrell R Boverhof
Department of Biochemistry and Molecular Biology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824 1319, USA
Mol Pharmacol 66:1662-70. 2004..Promoter activity was also dependent on a functional AhR signaling pathway. These results indicate that Socs2 is a primary TCDD-inducible gene that may represent a novel mechanism by which TCDD elicits its immunosuppressive effects...
- A novel nonconsensus xenobiotic response element capable of mediating aryl hydrocarbon receptor-dependent gene expressionGengming Huang
Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555 0654, USA
Mol Pharmacol 81:338-47. 2012....
- Induction of oxidative stress in rat epididymal sperm after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxinC Latchoumycandane
School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
Arch Toxicol 76:113-8. 2002..In conclusion, the adverse effect on male reproduction in TCDD-treated rats may be due to the induction of oxidative stress in sperm...
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced change in intestinal function and pathology: evidence for the involvement of arylhydrocarbon receptor-mediated alteration of glucose transportationTakumi Ishida
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
Toxicol Appl Pharmacol 205:89-97. 2005..The data provided here also suggest that AhR is involved in the mechanism of SGLT1 induction...
- Serum dioxin concentrations and age at menopauseBrenda Eskenazi
School of Public Health, University of California at Berkeley, Berkeley, California 94720 7360, USA
Environ Health Perspect 113:858-62. 2005..04). These results suggest a nonmonotonic dose-related association with increasing risk of earlier menopause up to about 100 ppt TCDD, but not above...
- Comparative contribution of the aryl hydrocarbon receptor gene to perinatal stage development and dioxin-induced toxicity between the urogenital complex and testis in the mouseSeiichiroh Ohsako
Division of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Biol Reprod 82:636-43. 2010..Further, the Ahr gene, analyzed in this study, does not significantly contribute to testicular function during perinatal and immature stages, and the developing mouse testis appears to be quite resistant to TCDD exposure...
- Transient increase in micronucleus frequency and DNA effects in the comet assay in two patients after intoxication with 2,3,7,8-tetrachlorodibenzo- p-dioxinEva Valic
Clinical Department of Occupational Medicine, University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
Int Arch Occup Environ Health 77:301-6. 2004..The genotoxic effects in two patients with 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) intoxication were measured; an association with the workplace was suspected...
- The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biologyManabu Nukaya
McArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 106:4923-8. 2009..Given the 100% penetrance of patent DV in Ahr null mice, these results indicate that Cyp1a1 and Cyp1a2 do not play a dominant role in AHR-mediated vascular development...
- Neonatal exposure to low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin causes autoimmunity due to the disruption of T cell toleranceNaozumi Ishimaru
Department of Oral Molecular Pathology, Institute of Health Biosciences, University of Tokushima Graduate School, Kuramotocho, Tokushima, Japan
J Immunol 182:6576-86. 2009..These results suggest that TCDD/aryl hydrocarbon receptor signaling in the neonatal thymus plays an important role in the early thymic differentiation related to autoimmunity...
- Detection of the TCDD binding-fingerprint within the Ah receptor ligand binding domain by structurally driven mutagenesis and functional analysisAlessandro Pandini
Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
Biochemistry 48:5972-83. 2009....
- In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,4,7,8-pentachlorodibenzofuran reduces growth and disrupts reproductive parameters in female ratsTravis B Salisbury
Department of Biological Sciences, Kent State University, Kent, Ohio 44242, USA
Biol Reprod 66:1621-6. 2002..The numbers of smaller follicles (both antral and small antral) were not different. Serum estradiol was significantly lower in TCDD-exposed animals 48 h after eCG stimulation...
- Dioxin and diabetes mellitus: an analysis of the combined NIOSH and Ranch Hand dataK Steenland
National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA
Occup Environ Med 58:641-8. 2001..To reanalyze in a similar manner the two principal studies of TCDD (tetrachlorodibenzo-p-dioxin) and diabetes in an attempt to reconcile disparate results...
- Dioxin concentrations in breast milk of Vietnamese nursing mothers: a survey four decades after the herbicide sprayingPham The Tai
Department of Epidemiology and Public Health, Kanazawa Medical University, Uchinada, Ishikawa, Japan
Environ Sci Technol 45:6625-32. 2011..84 pg/g lipid for multiparae, respectively, with significant differences in the values among the three areas. In the hot spots, dioxin levels were highly correlated with the residency of mothers after adjustment for their age and parity...
- Dioxin silences gonadotropin expression in perinatal pups by inducing histone deacetylases: a new insight into the mechanism for the imprinting of sexual immaturity by dioxinTomoki Takeda
Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
J Biol Chem 287:18440-50. 2012..These results strongly suggest that the increased deacetylation of histone owing to HDAC induction plays a critical role in the TCDD-induced reduction in LHβ in the fetal pituitary...
- Role of CYP1A2 in hepatic sequestration of dioxin: studies using CYP1A2 knock-out miceJ J Diliberto
Experimental Toxicology Division, National Health Effects and Environmental Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Biochem Biophys Res Commun 236:431-3. 1997..As demonstrated by the liver-to-adipose tissue (L/F) concentration ratios, there was no hepatic sequestering of TCDD and 4-PeCDF in the transgenic knock-out mice...
- Three-generation experiment showed female C57BL/6J mice drink drainage canal water containing low level of TCDD-like activity causing high pup mortalityLi Huang
Experimental Animal Research center, Guangzhou Medical College, Yuexiu District, Guangzhou, China
J Toxicol Sci 36:713-24. 2011..Considering this canals are open directly to Pearl River, whether these effects could be caused in human reproduction and development warrants further study...
- METABOLISM OF ENVIRONMENTAL CONTAMINANTS BY FISHJOHN LECH; Fiscal Year: 1992..model inducers to be studied include 3- methylcholanthrene (3-MC), beta-naphthoflavone (BNF), 2,3,7,8- tetrachlorodibenzodioxin (TCDD) and 2,3,7,8-tetra- chlorodibenzofuran (TCDF)...
- TOXICOLOGY OF ENVIRONMENT CONTAMINANTSStephen Safe; Fiscal Year: 2007..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
- Inhibition of Pancreatic Cancer by New PPARgamma Agonis*Stephen Safe; Fiscal Year: 2008..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
- ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXESStephen Safe; Fiscal Year: 2002..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
- Colon Cancer Inhibition by a Class of PPARgamma AgonistsStephen Safe; Fiscal Year: 2009..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
- Coactivation of Estrogen Receptor alpha/Sp1Stephen Safe; Fiscal Year: 2006..abstract_text> ..
- ALKYL PCDFS--INHIBITION OF MAMMARY CANCERStephen Safe; Fiscal Year: 2001..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
- Mechanisms of Growth Factor-Estrogen Receptor CrosstalkStephen Safe; Fiscal Year: 2006..abstract_text> ..
- 2,3,7,8,--TCDD Effects on the Estrogenic ResponsesStephen Safe; Fiscal Year: 2006..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
- RECEPTOR MEDIATED OXIDATIVE STRESSHOWARD SHERTZER; Fiscal Year: 2003..These studies will improve our understanding of how PHAHs such as TCDD generate oxidative stress and mutagenesis, leading to better models for risk assessment and novel strategies for intervention in PHAH-mediated toxicity. ..
- Glutathione in Environmental Toxicity and DiseaseHOWARD SHERTZER; Fiscal Year: 2007..Our proposed research should therefore help focus future genotype-phenotype association studies between the appropriate DNA variant sites in the GCLC and GCLM genes and disease. ..
- Long Term Toxicity of Di- and Tri-ChloroacetateEzdihar Hassoun; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- MECHANISM OF ESTROGENICITY OF DDT ANALOGS IN MCG-7 CELLSFumio Matsumura; Fiscal Year: 2001..The PI finally will address the fundamental question of whether c-Neu activation serves as a major gateway in addition to the estrogen receptor for xenobiotics to cause truly estrogenic cellular responses or not. ..
- Breast stem cell analysis in random periareolar fine needle aspirates from high rBRIAN PETROFF; Fiscal Year: 2008..Overall, this work has the potential to improve our understanding of breast stem cells and cancer risk and refine breast cancer prevention through a novel stem cell-targeted approach. [unreadable] [unreadable] [unreadable]..
- Reducing pesticide exposures to farmworker children.Brenda Eskenazi; Fiscal Year: 2005....
- Aryl hydrocarbon receptor pathway and reproductive agingBRIAN PETROFF; Fiscal Year: 2006..abstract_text> ..
- AhR and reproductive agingBRIAN PETROFF; Fiscal Year: 2008..This project will provide crucial knowledge for the identification and prevention of infertility and birth defects due to the AhR pathway in older mothers. [unreadable] [unreadable] [unreadable]..
- PBDEs, DDT and Neurodevelopment in School-Aged Mexican-American ChildrenBrenda Eskenazi; Fiscal Year: 2010....
- Genetic damage in the sperm and blood of workers exposed to benzeneBrenda Eskenazi; Fiscal Year: 2008..Lastly, this study is one of the first to investigate the relative sensitivities of sperm and blood cells to chromosomal defects induced by benzene. [unreadable] [unreadable] [unreadable]..
- Endocrine Disruptors and Neurodevelopmental OutcomesBrenda Eskenazi; Fiscal Year: 2004..This study will provide the first data on exposure and health effects of ED pesticides in a highly exposed population, complete the exposure profile of CHAMACOS children, and target interventions to reduce child exposures. ..
- Experimental Endometriosis in Mice After Adoptive Transfer of Human Immune CellsKAYLON BRUNER TRAN; Fiscal Year: 2008..With this information, better treatment strategies that target immune cell factors could begin to be developed. [unreadable] [unreadable] [unreadable]..
- Regulation of cyp1a1 by Ah Receptor and NFkB InteractionYanan Tian; Fiscal Year: 2009..The proposed studies will help us gain mechanistic understandings of the functions of AhR and NF-kB in normal physiology as well as pathogenesis induced by dioxin and related compounds. ..
- Training Program in Molecular and Cellular ToxicologyJohn Reiners; Fiscal Year: 2008..It is envisioned that students with such training will be better equipped to pursue postdoctoral research at major research laboratories throughout the United States. ..
- Prenatal TCDD and postnatal autoimmune diseaseSteven Holladay; Fiscal Year: 2007..The collective experiments are designed to detect alterations in fetal immune development caused by TCDD that underlie the worsened postnatal (postpubertal) autoimmune disease caused by this chemical. ..
- SCREENS TO IDENTIFY GAIN OF FUNCTION AH RECEPTOR MUTANTS INVOLVED IN DEGRADATIONRICHARD POLLENZ; Fiscal Year: 2008..e. steroid hormone receptors). [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- IMPACT OF AH RECEPTOR DEGRADATION IN VIVO AND IN VITRORICHARD POLLENZ; Fiscal Year: 2005..abstract_text> ..
- Columbia-GHI Consortium for Claims-Based Cancer StudiesSTEVEN STELLMAN; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Roles of CYP1 & 19 in Fundulus Steroids & PAH MetabolismKristine Willett; Fiscal Year: 2009..This research will further define the utility of Fundulus as a model organism for studying PAH-associated toxicities and in the development of human CYP19 or CYP1 B-related therapeutics. ..
- Role of Retroelements in Environmental AtherogenesisKenneth S Ramos; Fiscal Year: 2010..Studies are proposed in this application to study the role of virus-like sequences in the onset and progression of environmentally-induced atherosclerosis in experimental systems. ..
- Perfluorooctane sulfonate (PFOS) Affects Immunity through PPAR-alpha.Margie Peden Adams; Fiscal Year: 2007..The unimmunized and immunized experiments will be conducted to control for possible differences in response related to lymphocyte activation from the immunization. [unreadable] [unreadable] [unreadable]..
- Analysis and Effect of Persistent Ah Receptor ActivationMichael Denison; Fiscal Year: 2008..abstract_text> ..
- Function and Regulation of Human Cytochrome P4502S1Oliver Hankinson; Fiscal Year: 2010....
- Neurobehavioral Teratology Society: Symposium on Pesticides and MetalsSusan Schantz; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- CARCINOGEN ACTIVATION AND SCREENING IN VARIANT CELLSOliver Hankinson; Fiscal Year: 2010..abstract_text> ..
- Carcinogenicity of EstrogensDAVID SPINK; Fiscal Year: 2009..These studies may elucidate roles of estrogen in the regulation of Ah responsiveness, CYP1 expression, and carcinogen bioactivation that may lead to novel breast cancer chemoprevention strategies. ..
- Cardiotoxicity Drug Screening Using ZebrafishChuenlei Parng; Fiscal Year: 2004..Zebrafish drug screens can serve as an intermediate step between cell-based and mammalian testing, streamlining the drug development timeline. ..
- DIETARY LIPIDS AND EXPERIMENTAL IGA NEPHROPATHYJames Pestka; Fiscal Year: 2009..abstract_text> ..
- Exploring epigenetic mechanisms of developmental immunologyB Paige Lawrence; Fiscal Year: 2007..Findings from these studies will improve our understanding of the mechanisms that underlie the fetal programming of adult diseases of the immune system. ..
- Clinical and Translational Science Institute in ArkansasPHILIP KERN; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Developmental arsenic exposure produces cognitive impairmentsVINCENT MARKOWSKI; Fiscal Year: 2006..The proposed research is designed to determine how inorganic arsenic impairs cognitive function following gestational exposure. [unreadable] [unreadable] [unreadable]..
- Zebrafish Screen for Neuroprotective Anti-oxidantsChuenlei Parng; Fiscal Year: 2005..Assessment of drug effects in a convenient vertebrate model, prior to evaluation in a complex system, such as mouse, can potentially streamline the drug development process and dramatically reduce costs. ..
- Ah Receptor and Cardiac Adrenergic SignalingREBECCA SOMMER; Fiscal Year: 2005..Completion of these studies will provide important mechanistic data on the cardiovascular toxicology of TCDD and provide insight into the normal role of the AhR in the developing heart. ..
- 2004 Mechanisms of Toxicity Gordon Research ConferenceKenneth Ramos; Fiscal Year: 2004..Thus, the 2004 conference is poised to continue its growth as the single leading small conference in toxicology. ..
- ASSAY FOR DETERMINING DRUG TOXICITYChuenlei Parng; Fiscal Year: 2004..abstract_text> ..
- MECHANISMS OF TCDD PULMONARY IMMUNOTOXICITYB Lawrence; Fiscal Year: 2004....
- OSTEOPONTIN AND OXIDATIVE STRESS IN ATHEROGENESISKenneth Ramos; Fiscal Year: 2003..These studies are important in view of the increasing scrutiny of the role of oxidative injury in the onset and progression of atherogenesis. ..
- Heme Oxygenase-Regulation, Function&Clinical ApplicationMAHIN MAINES; Fiscal Year: 2003....
- COLLAGENASE REMOVAL IN OSTEOARTHRITISNicola Partridge; Fiscal Year: 2002..This work will offer insight into the basic pathophysiology of osteoarthritis and will be the basis for a new treatment option as well as determining the mechanisms of that treatment. ..
- ENDOTOXIN AND SUSCEPTIBILITY TO TRICHOTHECENE MYCOTOXINSJames Pestka; Fiscal Year: 2002..Over the long term, this research will provide insight into adverse immunologic consequences that may occur in LPS-exposed individuals who are exposed to environmental toxicants." ..
- MECHANISM OF INDUCTION OF OLFACTORY TUMORS BY ALACHLORMary Beth Genter; Fiscal Year: 2002....
- MOLECULAR MECHANISMS OF CHEMICAL ATHEROGENESISKenneth Ramos; Fiscal Year: 2005..These studies will enable us to define the role of ARE/EpRE binding proteins in oxidant-induced atherogenesis and identify critical transacting factors involved in the atherogenic response to environmental injury. ..
- DNA Damage as Women Age: Implications for Breast CancerDONALD MALINS; Fiscal Year: 2005....
- LEARNING THROUGH ENVIRONMENTAL HEALTH SCIENCE SCENARIOSNancy Kerkvliet; Fiscal Year: 2006..As a result of this project, it is hoped that students will demonstrate improved academic performance, decision-making skills, and attitudes toward science and school, as well as increased knowledge of environmental health issues. ..
- Akt activation sustains silica induced inflammationCELINE BEAMER; Fiscal Year: 2006..abstract_text> ..
- 2-METHOXYESTRADIOL & HORMONAL CANCERBao Ting Zhu; Fiscal Year: 2006..The results will also provide novel mechanistic understanding for the biological actions of 2-MeO-E2. ..
- ARNT:Roles in Tumor Induction and Growth, and Toxicity.Oliver Hankinson; Fiscal Year: 2006..abstract_text> ..
- Elucidation of the hr-dependent pathway of hair growthAndrey Panteleyev; Fiscal Year: 2005..Thus, the experiments outlined in this proposal are designed to dissect the cellular and molecular mechanisms of hair follicle catagen transformation using the hairless phenotype as an experimental model. ..
- "Ligand Independent" endocrine disruption by pesticidesPatrick Wong; Fiscal Year: 2005..abstract_text> ..
- FETAL ALCOHOL SYNDROME: GENETIC STUDIES IN ZEBRAFISHMICHAEL CARVAN; Fiscal Year: 2002..abstract_text> ..
- TCDD Impairs Prostate Development: Cyp2c39 & RetinoidsCHAD VEZINA; Fiscal Year: 2008..abstract_text> ..
- Asbestos Disease Among Household Contacts of Vermiculite WorkersAlfred Franzblau; Fiscal Year: 2006..In addition, tests for trend will be conducted to[unreadable] determine significant increasing pleural changes in household contacts by increasing indices of exposure. ..
- Xenobiotic Receptors in toxicology and CarcinogenesisGary Perdew; Fiscal Year: 2002..A detailed web site has been established: http://www. bmb. psu. edu/symposium/. ..
- Cloning of Ah receptor bound regulatory DNAGary Perdew; Fiscal Year: 2005..This method should in the future be utilized in biology for a wide range of mechanistic studies. ..
- Biochemical analysis of the human vs. mouse Ah receptorGary Perdew; Fiscal Year: 2007..Collectively, these studies will establish the level of divergence in human vs. mouse AhR function and should allow a better assessment of the significance of human exposure to TCDD. [unreadable] [unreadable] [unreadable]..