dioxins

Summary

Summary: Chlorinated hydrocarbons containing heteroatoms that are present as contaminants of herbicides. Dioxins are carcinogenic, teratogenic, and mutagenic. They have been banned from use by the FDA.

Top Publications

  1. pmc Serum dioxins and polychlorinated biphenyls are associated with growth among Russian boys
    Jane S Burns
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Building I, Room 1404E, Boston, MA 02115, USA
    Pediatrics 127:e59-68. 2011
  2. pmc Perinatal exposure to low doses of dioxin can permanently impair human semen quality
    Paolo Mocarelli
    University Department of Laboratory Medicine, Hospital of Desio, Monza Brianza, Italy
    Environ Health Perspect 119:713-8. 2011
  3. pmc The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds
    Martin van den Berg
    World Health Organization Collaborating Centre for Research on Environmental Health Risk Assessment and Institute for Risk Assessment Sciences, Science and University Medical Center, Universiteit Utrecht, The Netherlands
    Toxicol Sci 93:223-41. 2006
  4. ncbi Modulation of oestrogen receptor signalling by association with the activated dioxin receptor
    Fumiaki Ohtake
    The Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 0032, Japan
    Nature 423:545-50. 2003
  5. ncbi Intrinsic AhR function underlies cross-talk of dioxins with sex hormone signalings
    Fumiaki Ohtake
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Biochem Biophys Res Commun 370:541-6. 2008
  6. pmc Linking dioxins to diabetes: epidemiology and biologic plausibility
    Rene B J Remillard
    Toxicology Program, University of Guelph, Guelph, Ontario, Canada
    Environ Health Perspect 110:853-8. 2002
  7. pmc Fate and complex pathogenic effects of dioxins and polychlorinated biphenyls in obese subjects before and after drastic weight loss
    Min Ji Kim
    INSERM, UMR S, Universite Paris Descartes, Centre Universitaire des Saints Peres, France
    Environ Health Perspect 119:377-83. 2011
  8. pmc Increased risk of diabetes and polychlorinated biphenyls and dioxins: a 24-year follow-up study of the Yucheng cohort
    Shu Li Wang
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli, Taiwan
    Diabetes Care 31:1574-9. 2008
  9. pmc Apparent half-lives of dioxins, furans, and polychlorinated biphenyls as a function of age, body fat, smoking status, and breast-feeding
    Meghan O Grady Milbrath
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109 2029, USA
    Environ Health Perspect 117:417-25. 2009
  10. ncbi An introduction to the molecular basics of aryl hydrocarbon receptor biology
    Josef Abel
    Institut fur umweltmedizinische Forschung IUF an der Heinrich Heine Universitat Dusseldorf gGmbH, Auf m Hennekamp 50, Dusseldorf, Germany
    Biol Chem 391:1235-48. 2010

Detail Information

Publications325 found, 100 shown here

  1. pmc Serum dioxins and polychlorinated biphenyls are associated with growth among Russian boys
    Jane S Burns
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Building I, Room 1404E, Boston, MA 02115, USA
    Pediatrics 127:e59-68. 2011
    We evaluated the associations of serum dioxins and polychlorinated biphenyls (PCBs) with longitudinally assessed growth measurements among peripubertal Russian boys.
  2. pmc Perinatal exposure to low doses of dioxin can permanently impair human semen quality
    Paolo Mocarelli
    University Department of Laboratory Medicine, Hospital of Desio, Monza Brianza, Italy
    Environ Health Perspect 119:713-8. 2011
    ..In recent decades, young men in some industrialized areas have reportedly experienced a decrease in semen quality...
  3. pmc The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds
    Martin van den Berg
    World Health Organization Collaborating Centre for Research on Environmental Health Risk Assessment and Institute for Risk Assessment Sciences, Science and University Medical Center, Universiteit Utrecht, The Netherlands
    Toxicol Sci 93:223-41. 2006
    ..for possible future inclusion in the TEF concept, including 3,4,4'-TCB (PCB 37), polybrominated dibenzo-p-dioxins and dibenzofurans, mixed polyhalogenated dibenzo-p-dioxins and dibenzofurans, polyhalogenated naphthalenes, and ..
  4. ncbi Modulation of oestrogen receptor signalling by association with the activated dioxin receptor
    Fumiaki Ohtake
    The Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 0032, Japan
    Nature 423:545-50. 2003
    Environmental contaminants affect a wide variety of biological events in many species. Dioxins are typical environmental contaminants that exert adverse oestrogen-related effects...
  5. ncbi Intrinsic AhR function underlies cross-talk of dioxins with sex hormone signalings
    Fumiaki Ohtake
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Biochem Biophys Res Commun 370:541-6. 2008
    ..Thus, these findings indicate that the cross-talk function of the AhR with sex hormone receptors is an intrinsic function of the AhR...
  6. pmc Linking dioxins to diabetes: epidemiology and biologic plausibility
    Rene B J Remillard
    Toxicology Program, University of Guelph, Guelph, Ontario, Canada
    Environ Health Perspect 110:853-8. 2002
    ..In this article, we review the epidemiologic studies and propose biologically plausible connections between dioxins and diabetes...
  7. pmc Fate and complex pathogenic effects of dioxins and polychlorinated biphenyls in obese subjects before and after drastic weight loss
    Min Ji Kim
    INSERM, UMR S, Universite Paris Descartes, Centre Universitaire des Saints Peres, France
    Environ Health Perspect 119:377-83. 2011
    ..In humans, persistent organic pollutants (POPs) are stored primarily in adipose tissue. Their total body burden and their contribution to obesity-associated diseases remain unclear...
  8. pmc Increased risk of diabetes and polychlorinated biphenyls and dioxins: a 24-year follow-up study of the Yucheng cohort
    Shu Li Wang
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli, Taiwan
    Diabetes Care 31:1574-9. 2008
    ..We aimed to examine the association between previous high exposures to PCBs and PCDFs and the cumulative incidence of type 2 diabetes and hypertension...
  9. pmc Apparent half-lives of dioxins, furans, and polychlorinated biphenyls as a function of age, body fat, smoking status, and breast-feeding
    Meghan O Grady Milbrath
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109 2029, USA
    Environ Health Perspect 117:417-25. 2009
    ....
  10. ncbi An introduction to the molecular basics of aryl hydrocarbon receptor biology
    Josef Abel
    Institut fur umweltmedizinische Forschung IUF an der Heinrich Heine Universitat Dusseldorf gGmbH, Auf m Hennekamp 50, Dusseldorf, Germany
    Biol Chem 391:1235-48. 2010
    ..a transcription factor of the bHLH/PAS family that is known to mediate the biochemical and toxic effects of dioxins, polyaromatic hydrocarbons and related compounds...
  11. ncbi Dioxins, the aryl hydrocarbon receptor and the central regulation of energy balance
    Jere Lindén
    Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, Finland
    Front Neuroendocrinol 31:452-78. 2010
    b>Dioxins are ubiquitous environmental contaminants that have attracted toxicological interest not only for the potential risk they pose to human health but also because of their unique mechanism of action...
  12. ncbi Ah receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functions
    Karl Walter Bock
    Department of Toxicology, Institute of Pharmacology and Toxicology, University of Tubingen, Tubingen, Germany
    Biochem Pharmacol 72:393-404. 2006
    ..The AhR is also recognized as the culprit for most toxic responses observed after exposure to dioxins and related compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)...
  13. pmc Cancer and developmental exposure to endocrine disruptors
    Linda S Birnbaum
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 111:389-94. 2003
    ..Implications of these new findings suggest that causes of endocrine-related cancers or susceptibility to cancer may be a result of developmental exposures rather than exposures existing at or near the time of tumor detection...
  14. pmc Dioxin exposure and age of pubertal onset among Russian boys
    Susan A Korrick
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 119:1339-44. 2011
    ..Animal data demonstrate associations of dioxin, furan, and polychlorinated biphenyl (PCB) exposures with altered male gonadal maturation. It is unclear whether these associations apply to human populations...
  15. pmc Dioxin and polychlorinated biphenyl concentrations in mother's serum and the timing of pubertal onset in sons
    Olivier Humblet
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 22:827-35. 2011
    Animal studies have demonstrated that timing of pubertal onset can be altered by prenatal exposure to dioxins or polychlorinated biphenyls (PCBs), but studies of human populations have been quite limited.
  16. pmc Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta
    H E Virtanen
    Departments of Physiology and Paediatrics, University of Turku, Turku, Finland
    Int J Androl 35:283-93. 2012
    In animal studies, exposure to dioxins has been associated with disrupted development of the male reproductive system, including testicular maldescent. Some polychlorinated biphenyls (PCBs) have also dioxin-like effects...
  17. ncbi The effect of in utero exposure to dioxins and polychlorinated biphenyls on reproductive development in eight year-old children
    Pen Hua Su
    Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan
    Environ Int 39:181-7. 2012
    We have previously reported on the effects of in utero exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) on thyroid function and growth hormone concentrations at birth and in ..
  18. pmc In utero exposure to dioxins and dioxin-like compounds and anogenital distance in newborns and infants
    Marina Vafeiadi
    Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain
    Environ Health Perspect 121:125-30. 2013
    Anogenital distance in animals is used as a measure of fetal androgen action. Prenatal exposure to dioxins and dioxin-like compounds in rodents causes reproductive changes in male offspring and decreases anogenital distance.
  19. ncbi Prenatal exposure to polychlorinated biphenyls and dioxins from the maternal diet may be associated with immunosuppressive effects that persist into early childhood
    Solvor Berntsen Stølevik
    Norwegian Institute of Public Health, NO 0403 Oslo, Norway
    Food Chem Toxicol 51:165-72. 2013
    ..whether prenatal exposure from the maternal diet to the toxicants polychlorinated biphenyls (PCBs) and dioxins is associated with the development of immune-related diseases in childhood...
  20. ncbi Effects of dioxins, PCBs, and PBDEs on immunology and hematology in adolescents
    Marike M Leijs
    Department of Paediatrics and Neonatology, Emma Children s Hospital Academic Medical Centre, Amsterdam, Netherlands
    Environ Sci Technol 43:7946-51. 2009
    b>Dioxins and PCBs are environmental pollutants, proven to be immunotoxic. In the period 1987-1991 a cohort of mother-baby pairs was initiated to detect abnormalities in relation to dioxin levels in the mother's milk...
  21. pmc Mortality rates among trichlorophenol workers with exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    James J Collins
    Epidemiology Department, The Dow Chemical Company, Midland, Michigan 48674, USA
    Am J Epidemiol 170:501-6. 2009
    The authors examined 1,615 workers exposed to dioxins in trichlorophenol production in Midland, Michigan, to determine if there were increased mortality rates from exposure...
  22. ncbi Molecular interactions of the aryl hydrocarbon receptor and its biological and toxicological relevance for reproduction
    P Pocar
    Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle Wittenberg, Grosse Steinstrasse 52, D 06097, Halle Saale, Germany
    Reproduction 129:379-89. 2005
    ....
  23. ncbi Prenatal exposure to polychlorinated biphenyls and dioxins is associated with increased risk of wheeze and infections in infants
    Solvor Berntsen Stølevik
    Norwegian Institute of Public Health, NO 0403 Oslo, Norway
    Food Chem Toxicol 49:1843-8. 2011
    ..We here report on the environmental pollutants polychlorinated biphenyls (PCBs) and dioxins, as well as acrylamide generated in food during heat treatment...
  24. ncbi Environmental exposure to dioxins and polychlorinated biphenyls reduce levels of gonadal hormones in newborns: results from the Duisburg cohort study
    Yuguang Cao
    Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Int J Hyg Environ Health 211:30-9. 2008
    ..axis (HPG) is being discussed as underlying developmental adversity of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs)...
  25. ncbi Maternal exposure to high levels of dioxins in relation to birth weight in women affected by Yusho disease
    Kiyomi Tsukimori
    Department of Obstetrics, Fukuoka Children s Hospital, Japan
    Environ Int 38:79-86. 2012
    ..In Japan in 1968, an accidental human exposure to rice oil contaminated with PCDDs, PCDFs, and PCBs, led to the development of Yusho disease...
  26. pmc Polychlorinated biphenyls and organochlorine pesticides in plasma predict development of type 2 diabetes in the elderly: the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) study
    Duk Hee Lee
    Department of Preventative Medicine, Kyungpook National University, Daegu, Korea
    Diabetes Care 34:1778-84. 2011
    ..However, evidence from prospective studies is sparse. This study was performed to evaluate prospective associations of type 2 diabetes with selected POPs among the elderly...
  27. ncbi Calculation of serum "total lipid" concentrations for the adjustment of persistent organohalogen toxicant measurements in human samples
    John T Bernert
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE Atlanta, Georgia 30341, United States
    Chemosphere 68:824-31. 2007
    ....
  28. pmc Cancer incidence in the population exposed to dioxin after the "Seveso accident": twenty years of follow-up
    Angela Cecilia Pesatori
    Unit of Epidemiology, Department of Preventive Medicine, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via San Barnaba 8, 20122 Milano, Italy
    Environ Health 8:39. 2009
    ..Possible long-term effects have been examined through mortality and cancer incidence studies. We have updated the cancer incidence study which now covers the period 1977-96...
  29. ncbi The extent and patterns of usage of Agent Orange and other herbicides in Vietnam
    Jeanne Mager Stellman
    Department of Health Policy and Management, Mailman School of Public Health, Columbia University, 600 West 168th Street, New York, New York 10032, USA
    Nature 422:681-7. 2003
    ..Our identification of specific military herbicide targets has led to a more coherent understanding of spraying. Common errors in earlier interpretations of the spray data are also discussed...
  30. ncbi Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms
    José M Matés
    Departmento de Biología Molecular y Bioquímica, Facultad de Ciencias, Campus de Teatinos, Universidad de Malaga, 29071 Malaga, Spain
    Free Radic Biol Med 49:1328-41. 2010
    ..This review provides an updated revision of the oxidant effects of some environmental contaminants such as dioxins and the heavy metals cadmium, cobalt, and copper...
  31. ncbi Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and anti-inflammatory properties
    A Reum Kim
    Division of Food Science and Biotechnology, Pukyong National University, Busan 608 737
    J Agric Food Chem 57:3483-9. 2009
    ..In conclusion, these results suggest that phlorofucofuroeckol A has a potential for functional foods with antioxidant and anti-inflammatory activities...
  32. ncbi Dioxin increases reactive oxygen production in mouse liver mitochondria
    Albert P Senft
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    Toxicol Appl Pharmacol 178:15-21. 2002
    ..To our knowledge, this is the first report to show that dioxin increases mitochondrial respiration-dependent reactive oxygen production, which may play an important role in dioxin-induced toxicity and disease...
  33. pmc What do we feed to food-production animals? A review of animal feed ingredients and their potential impacts on human health
    Amy R Sapkota
    Johns Hopkins Center for a Livable Future, Bloomberg School of Public Health, Baltimore, Maryland, USA
    Environ Health Perspect 115:663-70. 2007
    ..In this article we review current U.S. animal feeding practices and etiologic agents that have been detected in animal feed. Evidence that current feeding practices may lead to adverse human health impacts is also evaluated...
  34. pmc Mortality in New Zealand workers exposed to phenoxy herbicides and dioxins
    A 't Mannetje
    Centre for Public Health Research, Research School of Public Health, Massey University Wellington Campus, PO Box 756, Wellington, New Zealand
    Occup Environ Med 62:34-40. 2005
    To evaluate mortality in New Zealand phenoxy herbicide producers and sprayers exposed to dioxins.
  35. pmc Immunologic biomarkers in relation to exposure markers of PCBs and dioxins in Flemish adolescents (Belgium)
    Rosette L Van Den Heuvel
    Department of Toxicology, Vito Flemish Institute of Technological Research, Mol, Belgium
    Environ Health Perspect 110:595-600. 2002
    ..The negative correlation between PHAHs and allergic responses in adolescents suggested that exposure may entail alterations in the immune status...
  36. ncbi The Duisburg birth cohort study: influence of the prenatal exposure to PCDD/Fs and dioxin-like PCBs on thyroid hormone status in newborns and neurodevelopment of infants until the age of 24 months
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Universitatsstr 150, 44801 Bochum, Germany
    Mutat Res 659:83-92. 2008
    Prenatal exposure to polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) can affect neurobehavioral development of infants and children...
  37. ncbi Dioxins and human toxicity
    Natalija Marinković
    Department of Chemistry and Biochemistry, Zagreb University School of Medicine, Salata 3, Zagreb, Croatia
    Arh Hig Rada Toksikol 61:445-53. 2010
    The term dioxins usually refers to polychlorinated dibenzo-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs)...
  38. pmc An overview of the effects of dioxins and dioxin-like compounds on vertebrates, as documented in human and ecological epidemiology
    Sally S White
    National Center for Environmental Assessment, U S Environmental Protection Agency, North Carolina, USA
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 27:197-211. 2009
    b>Dioxins and dioxin-like compounds are primary examples of persistent organic pollutants that induce toxicity in both wildlife and humans...
  39. ncbi Persistent organochlorine chemicals in plasma and risk of non-Hodgkin's lymphoma
    Anneclaire J De Roos
    Fred Hutchinson Cancer Research Center and University of Washington Department of Epidemiology, Seattle, Washington 98109 1024, USA
    Cancer Res 65:11214-26. 2005
    ..Congeners of PCBs (including coplanar congeners), dioxins, furans and pesticides or pesticide metabolites were measured in plasma of 100 untreated cases and 100 control ..
  40. pmc Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are mediated by different cell types
    Jacqueline A Walisser
    McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 102:17858-63. 2005
    ..Taken together, these data illustrate the importance of cell-specific receptor signaling for the generation of distinct AHR-dependent physiological outcomes...
  41. pmc The need and potential of biosensors to detect dioxins and dioxin-like polychlorinated biphenyls along the milk, eggs and meat food chain
    Jeerasak Chobtang
    Animal Production Systems Group, Wageningen University, P O Box 338, 6700 AH Wageningen, The Netherlands
    Sensors (Basel) 11:11692-716. 2011
    b>Dioxins and dioxin-like polychlorinated biphenyls (DL-PCBs) are hazardous toxic, ubiquitous and persistent chemical compounds, which can enter the food chain and accumulate up to higher trophic levels...
  42. ncbi Blood levels of dioxins, furans, dioxin-like PCBs, and TEQs in general populations: a review, 1989-2010
    Dario Consonni
    Unit of Epidemiology, Department of Preventive Medicine, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Environ Int 44:151-62. 2012
    A comprehensive worldwide literature review of blood levels of dioxins and dioxin-like compounds in non-exposed adult general populations was performed...
  43. pmc Detection and characterization of conjugative degradative plasmids in xenobiotic-degrading Sphingomonas strains
    Tamara Basta
    Institut fur Mikrobiologie, Universitat Stuttgart, Allmandring 31, D 70569 Stuttgart, Germany
    J Bacteriol 186:3862-72. 2004
    ..HH69 and of pBN6 to Sphingomonas sp. SS3. No indications for the transfer of a Sphingomonas plasmid to bacteria outside of the Sphingomonadaceae were obtained...
  44. ncbi Soft-tissue sarcoma and non-Hodgkin's lymphoma clusters around a municipal solid waste incinerator with high dioxin emission levels
    J F Viel
    Department of Public Health, Faculty of Medicine, Besancon, France
    Am J Epidemiol 152:13-9. 2000
    ..g., a case-control study in which dioxins are measured in biologic tissues) before clusters of soft-tissue sarcoma and non-Hodgkin's lymphoma are ascribed ..
  45. pmc Environmental health risk assessment of dioxin exposure through foods in a dioxin hot spot-Bien Hoa City, Vietnam
    Tran Thi Tuyet-Hanh
    Hanoi School of Public Health, Hanoi, Vietnam
    Int J Environ Res Public Health 7:2395-406. 2010
    ....
  46. ncbi Changes in concentrations of hydrophilic organic contaminants and of endocrine-disrupting potential downstream of small communities located adjacent to headwaters
    B Jarosova
    Research Centre for Toxic Compounds in the Environment RECETOX, Faculty of Science, Masaryk University, Kamenice 126 3, 62500, Brno, Czech Republic
    Environ Int 45:22-31. 2012
    ..Chemical analyses along with the results of bioassays documented impacts of small towns with WWTPs on headwaters...
  47. pmc The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons
    Michael D Kim
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
    Genes Dev 20:2806-19. 2006
    ..These findings suggest that one evolutionarily conserved role for Ahr in neuronal development concerns the diversification of dendrite morphology...
  48. ncbi Dioxins and organohalogen contaminants in the Asia-Pacific region
    Shinsuke Tanabe
    Center for Marine Environmental Studies, Ehime University, Matsuyama, Japan
    Ecotoxicology 19:463-78. 2010
    ..multi-media monitoring studies were compiled and discussed to provide in-depth understanding on various issues of dioxins and organohalogen contamination in both ambient environment and animals including humans...
  49. ncbi Amino acid sequence of the ligand-binding domain of the aryl hydrocarbon receptor 1 predicts sensitivity of wild birds to effects of dioxin-like compounds
    Reza Farmahin
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    Toxicol Sci 131:139-52. 2013
    ..93, p < 0.0001) with in ovo toxicity data for those species. These results indicate promise for the use of AHR1 LBD amino acid sequences independently, or combined with the LRG assay, to predict avian species sensitivity to DLCs...
  50. ncbi Immunological effects of environmental exposure to polychlorinated biphenyls and dioxins in Dutch school children
    Nynke Weisglas-Kuperus
    Division of Neonatology, Department of Pediatrics, Erasmus University and University Hospital Sophia Children s Hospital, P O Box 2060, 3000 CB Rotterdam, The Netherlands
    Toxicol Lett 149:281-5. 2004
    Perinatal exposure to PCBs and dioxins is associated with immune changes in healthy Dutch preschool children...
  51. ncbi Changes in toxicity and dioxin-like activity of sediments from the Tietê River (São Paulo, Brazil)
    Paula Suares Rocha
    Aquatic Ecology and Toxicology Section, Institute for Zoology, University of Heidelberg, Im Neuenheimer Feld 230, D 69120 Heidelberg, Germany
    Ecotoxicol Environ Saf 73:550-8. 2010
    ..Moreover, they indicate additional sources of pollutants along the river course, which contribute to the degradation of each reservoir...
  52. pmc Predictors of serum dioxins and PCBs among peripubertal Russian boys
    Jane S Burns
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 117:1593-9. 2009
    Although sources and routes of exposure to dioxins and polychlorinated biphenyls (PCBs) have been studied, information regarding exposure among children is limited...
  53. ncbi Anogenital distances in newborns and children from Spain and Greece: predictors, tracking and reliability
    Eleni Papadopoulou
    Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain
    Paediatr Perinat Epidemiol 27:89-99. 2013
    ..We examined anogenital distance measurements and their predictors in males and females and further estimated the reliability of these measurements...
  54. ncbi Effect-directed analysis of mutagens and ethoxyresorufin-o-deethylase inducers in aquatic sediments
    Werner Brack
    Department of Chemical Ecotoxicology, UFZ Centre for Environmental Research, Permoserstrasse 15, D 04318 Leipzig, Germany
    Environ Toxicol Chem 24:2445-58. 2005
    ..Dioxin-like halogenated aromatic hydrocarbons, including polychlorinated biphenyls, naphthalenes, dibenzo-p-dioxins and furans, and priority polycyclic aromatic hydrocarbons, contributed to Ah receptor-mediated activity only to a ..
  55. pmc Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans
    Amit Gupta
    The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390 9110, USA
    Environ Health Perspect 114:1649-54. 2006
    ..It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, ..
  56. ncbi Role of CYP1A2 in hepatic sequestration of dioxin: studies using CYP1A2 knock-out mice
    J J Diliberto
    Experimental Toxicology Division, National Health Effects and Environmental Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Biochem Biophys Res Commun 236:431-3. 1997
    ..As demonstrated by the liver-to-adipose tissue (L/F) concentration ratios, there was no hepatic sequestering of TCDD and 4-PeCDF in the transgenic knock-out mice...
  57. ncbi Risk assessment of dioxin contamination in human food
    W Parzefall
    Institute of Cancer Research, Department of Toxicology, University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria
    Food Chem Toxicol 40:1185-9. 2002
    b>Dioxins are highly toxic by-products of incineration processes and of production of chloro-organic chemicals. Accidental poisonings have occurred repeatedly. The main human exposure is via the dietary route...
  58. ncbi Polychlorinated biphenyls, dioxins, and furans in weaned, free-ranging northern elephant seal pups from central California, USA
    Cathy Debier
    Unite de Biochimie de la Nutrition, Universite Catholique de Louvain, Croix du Sud 2 8, B 1348 Louvain la Neuve, Belgium
    Environ Toxicol Chem 24:629-33. 2005
    ..Blubber concentrations of polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins, and polychlorinated dibenzofurans averaged 700 +/- 130 microg/kg, 32 +/- 23 ng/kg, and 17 +/- 5 ng/kg (lipid wt),..
  59. ncbi A bioassay approach to determine the dioxin-like activity in sediment extracts from the Danube River: ethoxyresorufin-O-deethylase induction in gill filaments and liver of three-spined sticklebacks (Gasterosteus aculeatus L.)
    Jens C Otte
    Department of Environmental Toxicology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Environ Int 34:1176-84. 2008
    ..Implementation of the EROD assay in testing of sediment extracts gave highly reliable results which make this assay an ecotoxicologically relevant method for assessment of contamination with Ah receptor agonists in sediments...
  60. ncbi Cooking process: a new source of unintentionally produced dioxins?
    Jiajia Wu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing, China
    J Agric Food Chem 59:5444-9. 2011
    To improve understanding of human background exposure to dioxins, the influence of cooking on dioxin concentrations in food has received much attention...
  61. ncbi Relative potencies of individual polycyclic aromatic hydrocarbons to induce dioxinlike and estrogenic responses in three cell lines
    D L Villeneuve
    Department of Zoology, National Food Safety and Toxicology Center, Institute for Environmental Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Environ Toxicol 17:128-37. 2002
    ..Overall, this research contributes to the growing consensus regarding the dioxinlike potency of priority PAHs and PAH derivatives and provides some additional evidence about potentially estrogenic PAHs...
  62. ncbi Changes in toxicity and Ah receptor agonist activity of suspended particulate matter during flood events at the rivers Neckar and Rhine - a mass balance approach using in vitro methods and chemical analysis
    Jan Wölz
    Department of Ecosystem Analysis, Institute for Environmental Research Biology V, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany
    Environ Sci Pollut Res Int 15:536-53. 2008
    ..1c4, GPC.2D.Luc, RTL-W1) were used to compare Ah receptor agonist activity in different biotest systems. Multilayer fractionation was performed to identify causative compounds, focusing on persistent organic contaminants...
  63. pmc AhR transcriptional activity in serum of Inuits across Greenlandic districts
    Manhai Long
    Unit of Cellular and Molecular Toxicology, Department of Environmental and Occupational Medicine, Institute of Public Health, University of Aarhus, Denmark
    Environ Health 6:32. 2007
    Human exposure to lipophilic persistent organic pollutants (POPs) including polychlorinated dibenzo-p-dioxins/furans (PCDDs/PCDFs), polychlorinated biphenyls (PCBs) and organochlorine pesticide is ubiquitous...
  64. ncbi Temporal trends in dioxins (polychlorinated dibenzo-p-dioxin and dibenzofurans) and dioxin-like polychlorinated biphenyls in Baltic herring (Clupea harengus)
    Aroha Miller
    Department of Environmental Research and Monitoring, Swedish Museum of Natural History, P O Box 50 007, SE 104 05 Stockholm, Sweden
    Mar Pollut Bull 73:220-30. 2013
    Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyl (dl-PCBs) concentrations in Baltic herring (Clupea harengus) have been relatively stable since the mid to late 1990s...
  65. ncbi Biological and chemical determination of dioxin-like compounds in sediments by means of a sediment triad approach in the catchment area of the river Neckar
    Ner Hollert
    Department of Zoology, University of Heidelberg, Germany
    Ecotoxicology 11:323-36. 2002
    ....
  66. ncbi Degradation of mono-chlorinated dibenzo-p-dioxins by Janibacter sp. strain YA isolated from river sediment
    Shoko Iwai
    Department of Urban Engineering, Graduate School of Engineering, The University of Tokyo, 7 3 1, Hougo, Bunko ku, Tokyo, 113 8656, Japan
    Curr Microbiol 51:353-8. 2005
    ..From the metabolites detected by gas chromatography-mass spectrometry, strain YA was supposed to have at least two types of oxidation pathways in 1-CDD degradation...
  67. ncbi Fate of Ah receptor agonists during biological treatment of an industrial sludge containing explosives and pharmaceutical residues
    Lillemor K Gustavsson
    Man Technology Environment Research Centre MTM, Department of Natural Science, University of Orebro, S 70182 Orebro, Sweden
    Environ Sci Pollut Res Int 11:379-87. 2004
    ..Therefore, we studied the sludge before and after the treatments in order to detect any changes in levels of Ah receptor (AhR) agonists using two bioassays for dioxin-like compounds...
  68. ncbi Air and soil dioxin levels at three sites in Italy in proximity to MSW incineration plants
    Stefano Caserini
    DIIAR Sezione Ambientale, Politecnico di Milano, P zza Leonardo da Vinci 32, 20133 Milano, Italy
    Chemosphere 54:1279-87. 2004
    Levels of polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF) in both air and soil samples were measured at three different sites in Italy, in proximity to three municipal solid waste incinerators (MSWIs) to ..
  69. ncbi Maternal-fetal distribution and transfer of dioxins in pregnant women in Japan, and attempts to reduce maternal transfer with Chlorella (Chlorella pyrenoidosa) supplements
    Shiro Nakano
    Saiseikai Nara Hospital, 4 chome, 8 jyo, Nara, Nara 630 8145, Japan
    Chemosphere 61:1244-55. 2005
    b>Dioxins can be transferred from mother to fetus via the placenta, or to nursing infants via breast milk, potentially causing developmental health problems in children...
  70. ncbi Fish products available in Polish market--assessment of the nutritive value and human exposure to dioxins and other contaminants
    Zygmunt Usydus
    Sea Fisheries Institute in Gdynia, Department of Food and Environment Chemistry, 1 Kollataja Str, Gdynia PL 81 332, Poland
    Chemosphere 74:1420-8. 2009
    ..However, many authors point at contaminants (methylmercury, PCDD/Fs) occurring in fish and fish products as on potential health problem, and emphasize that the amount of that hazardous substances should be limited in human diet...
  71. pmc Characterization of a C-C bond hydrolase from Sphingomonas wittichii RW1 with novel specificities towards polychlorinated biphenyl metabolites
    Stephen Y K Seah
    Department of Biochemistry, Universite Laval, Canada
    J Bacteriol 189:4038-45. 2007
    Sphingomonas wittichii RW1 degrades chlorinated dibenzofurans and dibenzo-p-dioxins via meta cleavage...
  72. ncbi Phlorofucofuroeckol A inhibits the LPS-stimulated iNOS and COX-2 expressions in macrophages via inhibition of NF-κB, Akt, and p38 MAPK
    A Reum Kim
    Department of Food Science and Nutrition, Pukyong National University, Busan 608 737, South Korea
    Toxicol In Vitro 25:1789-95. 2011
    ....
  73. ncbi Country-specific chemical signatures of persistent environmental compounds in breast milk
    K Krysiak-Baltyn
    Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark
    Int J Androl 33:270-8. 2010
    ..Therefore, we undertook a comprehensive ecological study of 121 EDCs, including the persistent compounds dioxins, polychlorinated biphenyls (PCBs), pesticides and flame retardants, and non-persistent phthalates, in 68 breast ..
  74. ncbi Daily intake of polychlorinated dibenzo-p-dioxins/polychlorinated dibenzofurans (PCDD/PCDFs) in foodstuffs consumed in Tarragona, Spain: a review of recent studies (2001-2003) on human PCDD/PCDF exposure through the diet
    Ana Bocio
    Laboratory of Toxicology and Environmental Health, School of Medicine, Rovira i Virgili University, San Lorenzo 21, 43201 Reus, Spain
    Environ Res 97:1-9. 2005
    Concentrations of polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF) were measured in foodstuffs randomly acquired in various locations of Tarragona County (Catalonia, Spain) in September 2002...
  75. ncbi Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and hepatoprotective properties in tacrine-treated HepG2 cells
    Min Sup Lee
    Department of Food Science and Nutrition, Pukyong National University, Busan 608 737, South Korea
    J Agric Food Chem 60:5340-9. 2012
    ..These results suggest that eckol and 2-phloroeckol are the principal hepatoprotective constituents of the ethyl acetate fraction of E. stolonifera ethanolic extract...
  76. pmc Dioxin-induced changes in epididymal sperm count and spermatogenesis
    Warren G Foster
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Environ Health Perspect 118:458-64. 2010
    ..Moreover, conflicting reports of TCDD effects on daily sperm production suggest that spermatogenesis may not be as sensitive to the adverse effects of TCDD as previously thought...
  77. ncbi Dioxin concentrations in breast milk of Vietnamese nursing mothers: a survey four decades after the herbicide spraying
    Pham The Tai
    Department of Epidemiology and Public Health, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Environ Sci Technol 45:6625-32. 2011
    ..These herbicides contained 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-tetraCDD), the most toxic congener of dioxins. Several decades after the herbicide spraying ceased, dioxin concentrations in the environment and human remained ..
  78. ncbi Polychlorinated biphenyls (PCBs) contamination and aryl hydrocarbon receptor (AhR) agonist activity of Omega-3 polyunsaturated fatty acid supplements: implications for daily intake of dioxins and PCBs
    J A Bourdon
    Mechanistic Studies Division, Environmental Health Sciences and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada
    Food Chem Toxicol 48:3093-7. 2010
    ..Further research will be necessary to draw firm conclusions...
  79. pmc Effects of perinatal exposure to PCBs and dioxins on play behavior in Dutch children at school age
    Hestien J I Vreugdenhil
    Department of Paediatrics, Division of Neonatology, Erasmus University Rotterdam and University Hospital Sophia Children s Hospital, Rotterdam, The Netherlands
    Environ Health Perspect 110:A593-8. 2002
    Polychlorinated biphenyls (PCBs) and dioxins are known as neurotoxic compounds that may modulate sex steroid hormones...
  80. ncbi Mortality rates among workers exposed to dioxins in the manufacture of pentachlorophenol
    James J Collins
    The Dow Chemical Company, Midland, Michigan 48674, USA
    J Occup Environ Med 51:1212-9. 2009
    We sought to determine if workers exposed to dioxins in pentachlorophenol (PCP) manufacturing were at increased risk of death from specific causes.
  81. ncbi Simultaneous exposure of non-diabetics to high levels of dioxins and mercury increases their risk of insulin resistance
    Jung Wei Chang
    Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    J Hazard Mater 185:749-55. 2011
    ..It is necessary to investigate and clarify the integrated effects of moderate-to-high exposure to dioxins and mercury on the pancreatic endocrine function...
  82. ncbi A follow-up: high level of dioxin contamination in Vietnamese from agent orange, three decades after the end of spraying
    Arnold Schecter
    J Occup Environ Med 44:218-20. 2002
  83. ncbi Bioanalytical screening methods for dioxins and dioxin-like compounds a review of bioassay/biomarker technology
    P A Behnisch
    Life Science Research Laboratories, Kaneka Corporation, Takasago, Japan
    Environ Int 27:413-39. 2001
    ..The relative potencies (REPs) to 2,3,7,8-TCDD for dioxin-like compounds are reviewed for various BDMs and the differences are noted...
  84. ncbi Differential uptake for dioxin-like compounds by zucchini subspecies
    Hideyuki Inui
    Research Center for Environmental Genomics, Kobe University, Kobe, Hyogo, Japan
    Chemosphere 73:1602-7. 2008
    ..of the 29 dioxin-like compounds that were assigned WHO-TEFs, three non-toxic polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs), and two non-dioxin-like polychlorinated biphenyls (PCBs) were analyzed...
  85. ncbi Environmental dioxins and endometriosis
    Sherry Rier
    Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Toxicol Sci 70:161-70. 2002
    ....
  86. ncbi The use of the DR CALUX bioassay and indicator polychlorinated biphenyls for screening of elevated levels of dioxins and dioxin-like polychlorinated biphenyls in eel
    Ron Hoogenboom
    RIKILT, Institute of Food Safety, Wageningen, The Netherlands
    Mol Nutr Food Res 50:945-57. 2006
    The DR CALUX bioassay is a very suitable screening method for dioxins and dioxin-like-PCBs in feed and food. This was, e. g. demonstrated in a survey in the Netherlands to control the dioxin levels in eel...
  87. pmc Predictors of serum dioxin, furan, and PCB concentrations among women from Chapaevsk, Russia
    Olivier Humblet
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Sci Technol 44:5633-40. 2010
    b>Dioxins, furans, and polychlorinated biphenyls (PCBs) are persistent and bioaccumulative toxic chemicals that are ubiquitous in the environment...
  88. ncbi Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother-newborn pairs
    Marie Pedersen
    Section of Environmental Health, Department of Public Health, University of Copenhagen, Oester Farimagsgade 5A, 1353 Copenhagen K, Denmark
    Environ Int 36:344-51. 2010
    ..4, P<0.003). This study demonstrated interactions in vivo between dioxin-like, estrogenic and androgenic exposures during fetal development of humans...
  89. ncbi Decreased lung function associated with perinatal exposure to Dutch background levels of dioxins
    G W ten Tusscher
    Department of Paediatrics and Neonatology, Emma Children s Hospital Academic Medical Centre, Amsterdam, The Netherlands
    Acta Paediatr 90:1292-8. 2001
    Perinatal exposure to Dutch background dioxin levels is rather high. Studies of calamities have shown that dioxins negatively influence the respiratory system...
  90. pmc Aryl hydrocarbon receptor-mediated down-regulation of sox9b causes jaw malformation in zebrafish embryos
    Kong M Xiong
    Departments of Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin 53705, USA
    Mol Pharmacol 74:1544-53. 2008
    ..These results suggest that reduced sox9b expression in TCDD-exposed zebrafish embryos contributes to jaw malformation...
  91. ncbi Enzyme-linked immunosorbent assay for monitoring toxic dioxin congeners in milk based on a newly generated monoclonal anti-dioxin antibody
    Mitsunobu Okuyama
    Food and Drug Safety Center, Hatano Research Institute, 729 5, Ochiai, Hadano, Kanagawa 257 8523, Japan
    Anal Chem 76:1948-56. 2004
    ..develop an enzyme-linked immunosorbent assay (ELISA) for monitoring the toxicity due to polychlorinated dibenzo-p-dioxins and dibenzofurans contaminated in human breast milk, we have generated novel monoclonal antibodies using some ..
  92. ncbi Biosensor immunoassay for the screening of dioxin-like polychlorinated biphenyls in retail fish
    Tomoaki Tsutsumi
    Division of Foods, National Institute of Health Sciences, Kamiyoga 1 18 1, Setagaya Ku, Tokyo 158 8501, Japan
    Anal Chim Acta 617:177-83. 2008
    ..polychlorinated biphenyls (DL-PCBs) often make up the majority of the toxic equivalent (TEQ) contribution of dioxins found in fish samples...
  93. ncbi [Study on dioxin emission for typical non-wood pulp making in China]
    Zhi fang Wang
    Foreign Economic Cooperation Office, Ministry of Environmental Protection, Beijing 100035, China
    Huan Jing Ke Xue 33:574-9. 2012
    ..At the same time, the text calculates emission factors on bamboo, straw, reed and bagasse pulp making process through whole process monitoring, which will provide meaningful reference for increasing relevant factors in UNEP Toolkit...
  94. ncbi PCB 118 and Aryl Hydrocarbon Receptor Immunoassays for Screening Dioxins in Retail Fish
    Tomoaki Tsutsumi
    National Institute of Health Sciences, Kamiyoga 1 18 1, Setagaya Ku, Tokyo 158 8501, Japan
    J Agric Food Chem 56:2867-74. 2008
    ..immunosorbent assay (ELISA) kits was examined for screening the toxic equivalent (TEQ) concentrations of dioxins in retail fish...
  95. ncbi Development of human dermal epithelial cell-based bioassay for the dioxins
    Jae Ho Yang
    Department of Pharmacology, School of Medicine, Catholic University of Daegu, 3056 6 Daemyong 4 dong, Namgu, Daegu 705 718, Republic of Korea
    Chemosphere 72:1188-92. 2008
    ..Here, we have developed a human epidermal cell-based bioassay for the dioxins and related compounds...
  96. pmc An enzyme-linked immunosorbent assay for the determination of dioxins in contaminated sediment and soil samples
    Jeanette M Van Emon
    US Environmental Protection Agency, National Exposure Research Laboratory, P O Box 93478, Las Vegas, NV 89193 3478, USA
    Chemosphere 72:95-103. 2008
    ..The ELISA could also be used in an analytical triage approach to screen and rank samples prior to instrumental analysis...
  97. ncbi Effects of o,p'-DDT on the 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible CYP1A1 expression in murine Hepa-1c1c7 cells
    Hye Gwang Jeong
    Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University, Kwangju, South Korea
    Food Chem Toxicol 40:1685-92. 2002
    ..These results suggest that the downregulation of CYP1A1 gene expression by o,p'-DDT in Hepa-1c1c7 cells might be an antagonism of the DRE binding potential of the nuclear Ah receptor but is not mediated through the estradiol receptor...
  98. ncbi Validation and interpretation of CALUX as a tool for the estimation of dioxin-like activity in marine biological matrixes
    Isabelle Windal
    Scientific Institute of Public Health, 1050 Brussels, Belgium
    Environ Sci Technol 39:1741-8. 2005
    ..Good correlations are usually observed, but there are systematic differences between the results. Attempts are made to identify the origin of the discrepancy between the two methods...
  99. ncbi Monitoring dioxins in food and feedstuffs using accelerated solvent extraction with a novel integrated carbon fractionation cell in combination with a CAFLUX bioassay
    Malin Nording
    Environmental Chemistry, Department of Chemistry, Umea University, 901 87 Umea, Sweden
    Anal Bioanal Chem 381:1472-5. 2005
    The concentrations of dioxins in fish oil and fish meal were determined with accelerated solvent extraction, using a novel integrated carbon fractionation extraction cell followed by a miniturized multilayer silica column and bioanalysis ..
  100. ncbi Regional comparisons of coastal sediment contamination detected by a biomarker (P450 HRGS; EPA Method 4425)
    Jack W Anderson
    Columbia Analytical Services, Kelso, Washington 98626, USA
    Environ Sci Technol 39:17-23. 2005
    ..with an affinity for Ah-receptor (certain polycyclic aromatic hydrocarbons, polychlorinated biphenyls, and dioxins/ furans)...
  101. ncbi 6,6'-Bieckol, isolated from marine alga Ecklonia cava, suppressed LPS-induced nitric oxide and PGE₂ production and inflammatory cytokine expression in macrophages: the inhibition of NFκB
    Yeong In Yang
    Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, South Korea
    Int Immunopharmacol 12:510-7. 2012
    ....

Research Grants63

  1. MOLECULAR MECHANISMS OF DIOXIN ACTION
    Alvaro Puga; Fiscal Year: 2013
    ..Our rationale is that mutations in the NKX2.5 gene and maternal exposure to halogenated hydrocarbons, dioxins and polychlorinated biphenyls during pregnancy are the main known risk factors for these human developmental ..
  2. Novel Zebrafish Models to Study Toxicity of PCBs and Pesticides During Pregnancy
    Lisa Satterwhite; Fiscal Year: 2009
    ..of HLH was discovered in children in the Baltimore-Washington area that correlated with accidental release of dioxins and polychlorinated biphenyls (PCBs)...
  3. Aryl Hydrocarbon Receptor Modulators for the Treatment of Hepatocellular Carcinom
    Siva Kumar Kolluri; Fiscal Year: 2012
    ..Aside from the AhR's role as the mediator of toxicity of various dioxins, recent studies have identified roles for the AhR in apoptosis, cell cycle regulation, and tumor suppression, all ..
  4. THE EFFECT OF DIOXINS ON GLUCOSE HOMEOSTASIS IN MURINE TESTES
    KENAN RIFAT OMURTAG; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dioxins represent a class of highly toxic and widely dispersed environmental hazards that have been implicated in aberrations in male reproductive cell function and even adverse pregnancy outcomes ..
  5. Dioxins and Male Pubertal Growth and Development
    Russ B Hauser; Fiscal Year: 2013
    ..hydrocarbons, a family of highly toxic environmental contaminants that includes polychlorinated dibenzo-p- dioxins, polychlorinated dibenzofurans and polychlorinated biphenyls (PCBs), and heavy metals, specifically lead...
  6. CHILDHOOD DIOXIN EXPOSURE AND ENERGY HOMEOSTASIS DYSREGULATION
    Jane S Burns; Fiscal Year: 2010
    ..Recent epidemiologic studies have reported associations of serum concentrations of polychlorinated dibenzo- p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs) with elevated serum glucose ..
  7. Training in Molecular and Mechanistic Toxicology
    Edson X Albuquerque; Fiscal Year: 2012
    ..in basic, clinical and ecological research applied to such environmental toxicants as metals, phytoestrogens, dioxins, and insecticides, and interests span from basic to clinical and environmental research...
  8. Developmental Ah receptor Activity in the CNS: Neurogenesis and Neurotoxicity
    Lisa A Opanashuk; Fiscal Year: 2013
    ..to the identification of factors that contribute to the anatomical and functional deficits following exposure to dioxins. PUBLIC HEALTH RELEVANCE: The results from these studies will be important for understanding the adverse effects ..
  9. Circadian Clock Disruption: A Mechanism for Dioxin-induced Metabolic Syndrome
    Shelley A Tischkau; Fiscal Year: 2013
    ..resistance and type 2 diabetes in humans with elevated body burden of certain lipophilic xenobiotics such as dioxins. These anthropogenic substances exert their effects through activation of aryl hyrdrocarbon receptor (AhR)...
  10. Role of Aryl hydrocarbon receptor (AhR) and RelB during the initiation of dendrit
    Christoph F A Vogel; Fiscal Year: 2010
    ..of the function of the AhR together with RelB and is critical in understanding how environmental toxicants like dioxins affect critical functions of the immune system and human health...
  11. Ah Receptor Dysregulation Alters Hematopoietic Stem Cells
    Thomas A Gasiewicz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human exposures to polycyclic aromatic hydrocarbons and dioxins have been linked to the development of lymphomas and leukemias...
  12. Jacksonville Racial and Ethnic Environmental Approaches to Community Health (REEA
    Cynthia M Harris; Fiscal Year: 2011
    ..for residents, particular concerns include contamination by lead, arsenic, polyaromatic hydrocarbons (PAHs) and dioxins. Four of these ash sites were of public concern and deemed a public health hazard due to the unacceptable levels ..
  13. Diabetes and Persistent Organic Pollutants
    MARY ELLEN TURYK; Fiscal Year: 2010
    ..Persistent organic pollutants (POPs) such as dioxins, polychlorinated biphenyls (PCBs), p,p'-diphenyldichloroethene (DDE), and polybrominated biphenyl ethers (..
  14. Transgenic Models of Ah Receptor Action
    Christopher A Bradfield; Fiscal Year: 2013
    ..transcription factor that mediates the biological effects of polycyclic aromatic hydrocarbons (PAHs), halogenated-dioxins ("dioxins"), - dibenzofurans, -biphenyls (PCBs), and -diphenylethers...
  15. Multiplexed Onchip Nanomagnetic Immunoassay for TOxin Reporting (MONITOR)
    John Collins; Fiscal Year: 2012
    ..The many forms of dioxins and other toxins that are found in the environment are relatively insoluble in water but soluble in many organic ..
  16. LSU Superfund Research Center - Environmentally Persistent Free Radicals
    Barry Dellinger; Fiscal Year: 2013
    ..devices, the EPFRs also promote the formation of new molecular pollutants, such as polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F)...
  17. POTENTIAL FOR ENVIRONMENTAL AND THERAPEUTIC AGENTS TO INDUCE IMMUNOTOXICITY
    Matthew Smith; Fiscal Year: 2012
    ..During this period we have conducted studies to examine the relative potencies of four brominated dioxins and furans as compared with their chlorinated counterparts...
  18. The Role of Aryl Hydrocarbon Receptor in Colon Tumorigenesis
    GREGORY DEAN KENNEDY; Fiscal Year: 2013
    ..linked to chemoprevention, how do we modulate doses so we do not mimic the pro-carcinogenic effects of dioxins? If it is not mechanistically related to chemoprevention, can we modify structures of the chemopreventative ..
  19. Environmental Microbial and Mammalian Biomolecular Responses to AhR Ligands
    Norbert E Kaminski; Fiscal Year: 2013
    ..These chemicals, which include chlorinated dibenzo-p-dioxins, dibenzofurans, biphenyls and polyaromatic hydrocarbons, are environmentally persistent, lipid soluble that ..
  20. Development of Stable Isotope Based Methods to Predict Bioavailability of Hydroph
    Jay Gan; Fiscal Year: 2013
    ..a key to better assessing human exposure to hydrophobic organic contaminants (HOCs) such as DDT, PCBs, PAHs and dioxins through consumption of fish from contaminated areas...
  21. LIGNIN BIODEGRADATON--LIGNINASE & GLUCOSE OXIDASE GENES
    CA REDDY; Fiscal Year: 1992
    ..of lignin, also play a key role in the detoxification of recalcitrant environmental pollutants such as dioxins, DDT, lindane and benzopyrenes, which constitute a serious public health hazard...
  22. The role of the aryl hydrocarbon receptor in colon tumorigenesis
    GREGORY DEAN KENNEDY; Fiscal Year: 2012
    ..chemoprevention, how do we modulate doses so that too much action does not mimic the procarcinogenic effects of dioxins? If it is not mechanistically related to chemoprevention, can we modify structures of the chemopreventative ..
  23. Studies on the Ah Receptors Signaling Mechanism
    William K Chan; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Dioxins, generated both commercially and naturally, are chlorinated polycyclic aromatic hydrocarbons that are highly toxic environmental contaminants...
  24. DIOXINS AND HYPOTHALAMIC APPETITE NEUROPEPTIDES
    GEORGE GREELEY; Fiscal Year: 2000
    ..PCAHs, such as polychlorinated dibenzo-rho-dioxins (PCDDs), biphenyls (PCBs) and dibenzofurans (PCDFs) represent a diverse group of widespread xenobiotics with long ..
  25. ORGANOCHLORINES AND METALS IN NEW YORK AND THE HUDSON
    Philip Landrigan; Fiscal Year: 2006
    ..region that is contaminated by a complex mix of organochlorines - PCBs, DDT, chlordane, dieldrin, and dioxins - as well as by heavy metals, especially lead and mercury...
  26. Novel Approaches to Studying the Situ Bioremediation of Complex Mixtures
    ROLF HALDEN; Fiscal Year: 2009
    ..We will use defined mixtures of chemicals (e.g., dioxins, PCBs, PAHs, tolualdeyhyde, Cd, Cr, Co, Pb, Hg, Zn, Ni) and bacteria (five bioremediation agents) to study these ..
  27. Aryl hydrocarbon receptor regulation of the cell cycle by chromatin modification
    REBEKA MERSON; Fiscal Year: 2009
    ..g., dioxins, polychlorinated biphenyls) and polycyclic aromatic hydrocarbons (e.g., dimethylbenzanthracene)...
  28. Industrial Pollutants and Risk of Non-Hodgkins Lymphoma
    Anneclaire De Roos; Fiscal Year: 2006
    ..with specific industrial pollutants of interest, including solvents, polycyclic aromatic hydrocarbons, and dioxins, will be examined after developing exposure contours based on emissions quantities and meterologic data...
  29. MECHANISM(S) OF TOXICITY OF THE CHLORINATED P-DIOXINS
    Robert Neal; Fiscal Year: 1980
    The polychlorinated dibenzo-p-dioxins are a class of generally toxic compounds which are found as contaminants of preparations of polychlorinated phenols...
  30. Reproductive Outcomes due to Past Exposure to Dioxins
    Irina Dardynskaia; Fiscal Year: 2005
    ..abstract_text> ..
  31. NEUROBEHAVIORAL CONSEQUENCES OF PRENATAL TCDD EXPOSURE
    Bernard Weiss; Fiscal Year: 2000
    ..Investigator's Abstract) Endocrine disruptors are a class of environmentally prevalent compounds that include the dioxins, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the polychlorinated biphenyls, and some isoflavonoid ..
  32. CHARACTERIZATION OF AH RECEPTOR-RADIOLIGAND INTERACTIONS
    Stephen Safe; Fiscal Year: 1991
    ..have resulted in methods for synthesizing several radiolabeled polychlorinated dibenzofurans and dibenzo-p-dioxins of high specific activity (35-55 Ci/mmol)...
  33. DEVELOPMENTAL EFFECTS OF FISH BORNE TOXICANTS IN THE RAT
    Richard Seegal; Fiscal Year: 2000
    ..containing the majority of the PCBs, DDE, HCB, mirex and chlordanes, and the other containing the coplanar PCBs, dioxins, dibenzofurans and polar pesticides and; (4) determine regio-specific neurochemical changes in animals exposed to ..
  34. STUDIES ON THE HALOGENATED AROMATIC HYDROCARBONS
    ALAN POLAND; Fiscal Year: 1990
    ..We are interested in three classes of xenobiotics: 1) 2,3,7,8-tetrachlorodibenzo-p-dioxins (TCDD) and related halogenated aromatic hydrocarbons; 2) phenobarbital and phenobarbital-like inducers; and 3) 2(..
  35. Integrating microbial biostimulation and electrolytic aeration to degrade POPs
    Harold D May; Fiscal Year: 2010
    ..contaminated with persistent organic pollutants (POPs) such as polychlorinated biphenyls, chlorobenzenes and dioxins have been an environmental concern for several decades...
  36. Ah Receptor Regulation of Prostate Tumor Progression
    Richard Peterson; Fiscal Year: 2006
    ..provided by applicant): The aryl hydrocarbon receptor (AhR) is a transcription factor that binds chlorinated dioxins, other xenobiotics, and various endogenous chemicals and mediates their effects on gene expression in most organs,..
  37. STRUCTURE AND FUNCTION OF THE DIOXIN RECEPTOR
    Jan Ake Gustafsson; Fiscal Year: 1991
    Halogenated aromatic hydrocarbons such as chlorinated or brominated dibenzo-p-dioxins, dibenzofurans or biophenyls are extremely toxic environmental pollutants produced inadvertently in industrial processes and/or combustion...
  38. BIOCHEMICAL CHARACTERIZATION OF THE AH RECEPTOR
    Gary Perdew; Fiscal Year: 1993
    ..g. dioxins)...
  39. Environmental Toxins Disrupt Ovarian Circadian Rhythms
    Shelley Tischkau; Fiscal Year: 2005
    ..b>Dioxins, which are ubiquitously found in the environmental and within all organisms, exert significant deleterious ..
  40. CONSEQUENCES OF THYMIC ATROPHY INDUCED BY TCDD AND E2
    Allen Silverstone; Fiscal Year: 2000
    Estrogens and dioxins induce immunosuppression and thymic atrophy. Estrogens also are associated with autoimmune disease, while dioxin has been shown to be associated with induction of markers of hyper-immunity...
  41. Studies on the Ah receptor signaling mechanism
    William Chan; Fiscal Year: 2002
    b>Dioxins, generated both commercially and naturally, are chlorinated polycyclic aromatic hydrocarbons that are highly toxic environmental contaminants...
  42. Zebrafish Assay for Identifying Endocrine Disruptors
    Catherine Willett; Fiscal Year: 2004
    ..occurring and man-made chemicals, such as phytoestrogens, organochlorine pesticides, polychlorinated biphenyls, dioxins, and synthetic estrogens, interfere with the endocrine system of vertebrates when released into the environment...
  43. DIOXIN TOXIC EQUIVALENCY FACTORS--BATTELLE MEMORIAL INST
    Milton Hejtmancik; Fiscal Year: 2000
    This project has been designed to test the following hypotheses: The USEPA interim TEFs for dioxins, dibenzofurans and PCBs can predict the relative carcinogenic potency of single congeners in female Sprague-Dawley rats...
  44. NEW TEST METHOD FOR DIOXINS IN HUMANS AND ANIMALS
    Randy Allen; Fiscal Year: 2000
    b>Dioxins and furans comprise one of the most deadly and feared families of pollutants in the world...
  45. Dissecting a novel role of dioxin in breast cancer susceptibility
    BETH VORDERSTRASSE; Fiscal Year: 2007
    ..our preliminary data suggest that by blocking normal pregnancy-associated mammary differentiation, exposure to dioxins may disrupt the normal signaling that ultimately protects breast tissue from cancer...
  46. CYP1A1, estrogen metabolism and ovarian carcinogenesis
    Shuk Mei Ho; Fiscal Year: 2004
    ..inflammation, hypoxia, sex hormones, caffeine, polycyclic aromatic hydrocarbons, polychlorinated biphenols, and dioxins. Furthermore, their activities regulate estrogen inactivation and activation to genotoxic metabolites...
  47. A Role of the Ah Receptor in Hematopoiesis: Model Characterization
    Thomas A Gasiewicz; Fiscal Year: 2010
    Human exposures to polycyclic aromtic hydrocarbons and dioxins have been linked to the development of lymphomas and leukemias. The actions of these chemicals are mediated by a gene regulatory protein, the aryl hydrocarbon receptor (AhR)...
  48. Gene Regulation by AHR and ER in Cancer Cells
    ELI HESTERMANN; Fiscal Year: 2005
    ..A large number of environmental contaminants (including combustion products, "dioxins" and polychlorinated biphenyls), plant natural products, and therapeutic compounds interact with AHR...
  49. ZEBRAFISH FIN REGENERATION: A MODEL FOR DIOXIN TOXICITY
    Robert Tanguay; Fiscal Year: 2004
    DESCRIPTION: (Adapted from the Applicant's Abstract) Polychlorinated dioxins, benzofurans and biphenyls are stable, lipophilic compounds that bioaccumulate in the food chain and produce toxicity through the arylhydrocarbon receptor (AhR)..
  50. STRUCTURE/FUNCTION OF BIPHENYL DIOXYGENASES
    JEFFREY BOLIN; Fiscal Year: 2001
    ..A number of these compounds, such as the PCBs and dioxins, are well-known as persistent pollutants of health and environmental significance...
  51. CELLULAR MECHANISMS OF ENDOCRINE DISRUPTERS
    Stuart Adler; Fiscal Year: 1999
    DESCRIPTION: (adapted from applicant's description) Many compounds such as insecticides, plasticizers, and dioxins can be classified as environmental estrogens or endocrine disrupters...
  52. IMMUNOTOXICITY OF PROPANIL AND TETRACHLOROAZOBENZENE
    John Barnett; Fiscal Year: 1993
    ..propanil and a metabolic breakdown product of propanil, has a similar structure to that of the well studied dioxins that have been shown to have potent immunotoxic properties...
  53. EFFECTS OF DIOXINS (TCDD) ON CARDIAC ION CHANNELS
    Desuo Wang; Fiscal Year: 2003
    ....
  54. DEVELOPMENT OF AH RECEPTOR-BASED TEQ TEST
    JOHN WILLEY; Fiscal Year: 2000
    ..The resulting system would be used to quantify AhR-binding toxicants such as dioxins, furans, and PCBs from clinical samples such as blood, serum or tissue, food samples such as meat fat, or ..
  55. The Ah Locus: Transgenic Models of cis/trans Modifiers
    Christopher Bradfield; Fiscal Year: 2005
    ..Applicant's Abstract): This proposal is directed at understanding the toxicology of halogenated dibenzo-p-dioxins ("dioxins"), as well as the biology of a basic-helix-loop-helix-PAS (bHLH-PAS) protein known as the Ah receptor (..
  56. ANTIBODY BASED METHODS FOR 2,3,7,8-TCDD ANALYSIS
    Robert Carlson; Fiscal Year: 1999
    DESCRIPTION: (Adapted from the applicant's abstract) Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) are significant environmental pollutants...
  57. Regulation of Prostate Cancer Progression by the AHR
    WAYNE FRITZ; Fiscal Year: 2004
    The aryl hydrocarbon receptor (AhR) is a signal transduction protein that binds chlorinated dioxins and other xenobiotics and mediates their effects on gene expression in various organs including the prostate...
  58. ORGANIC PHASE IMMUNOASSAY FOR CHLORINATED DIBENZODIOXINS
    Gary Bignami; Fiscal Year: 1992
    ..1% (w/w) water. The proposed research will result in the development of an OPRIA for polychlorinated dibenzo-p-dioxins (PCDDs)...
  59. VALIDATION OF A BIOASSAY FOR DIOXIN-LIKE TOXICANTS
    George Clark; Fiscal Year: 2000
    ..Once validated, the CALUX assay will provide an inexpensive method of screening for dioxins and similar chemicals in biological, environmental and industrial samples...