antipyrine

Summary

Summary: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)

Top Publications

  1. ncbi Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2, Ohno Higashi, Osakasayama, Osaka 589 8511, Japan
    Neurochem Res 35:348-55. 2010
  2. ncbi Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain
    Ning Zhang
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Tokyo 113 0033, Japan
    Stroke 36:2220-5. 2005
  3. ncbi Administration of edaravone, a free radical scavenger, during t-PA infusion can enhance early recanalization in acute stroke patients--a preliminary study
    Kazumi Kimura
    Department of Stroke Medicine, Kawasaki Medical School, Japan
    J Neurol Sci 313:132-6. 2012
  4. ncbi Beneficial effects of edaravone, a novel antioxidant, in rats with dilated cardiomyopathy
    Somasundaram Arumugam
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    J Cell Mol Med 16:2176-85. 2012
  5. ncbi Edaravone mimics sphingosine-1-phosphate-induced endothelial barrier enhancement in human microvascular endothelial cells
    Kazuyoshi Omori
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Am J Physiol Cell Physiol 293:C1523-31. 2007
  6. pmc Free-radical scavenger edaravone treatment confers neuroprotection against traumatic brain injury in rats
    Guo hua Wang
    Department of Neuropharmacology, Institute of Nautical Medicine, Nantong University, Nantong, Jiangsu, China
    J Neurotrauma 28:2123-34. 2011
  7. ncbi Edaravone, a free radical scavenger, protects against retinal damage in vitro and in vivo
    Yuta Inokuchi
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu, Japan
    J Pharmacol Exp Ther 329:687-98. 2009
  8. ncbi Beyond neurological disease: new targets for edaravone (Review)
    Kiyoshi Kikuchi
    Department of Neurosurgery, Yame Public General Hospital, Yame 834 0034, Japan
    Int J Mol Med 28:899-906. 2011
  9. ncbi Effect of a free radical scavenger, edaravone, in the treatment of patients with aneurysmal subarachnoid hemorrhage
    Akira Munakata
    Department of Neurosurgery, Hirosaki University School of Medicine, Hirosaki, Japan
    Neurosurgery 64:423-8; discussion 428-9. 2009
  10. ncbi Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator
    Kenji Yagi
    Department of Neurosurgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Stroke 40:626-31. 2009

Research Grants

  1. MASS SPECTROMETER SYSTEM AND ACCESSORIES
    ALAN NIES; Fiscal Year: 1990
  2. Brain serotonin and angiotensin II systems in migraine
    JOSE TERRON; Fiscal Year: 2007
  3. ABNORMAL METABOLISM IN ALCOHOLIC CIRRHOSIS
    Rajender Chawla; Fiscal Year: 1993
  4. SEVERE DIFFUSE TRAUMATIC BRAIN INJURY
    P David Adelson; Fiscal Year: 2001
  5. FETAL NUTRIENT THERAPY: EFFECTS ON GROWTH RETARDATION
    Valerie Charlton; Fiscal Year: 1992
  6. BODY COMPOSITION IN NEONATES OF DIABETIC MOTHERS
    YVES BRANS; Fiscal Year: 1980
  7. PET Behavioral Brain Mapping In Freely Moving Animals
    DANIEL HOLSCHNEIDER; Fiscal Year: 2006
  8. Microinfusion Pump For Animal Functional Brain Mapping
    DANIEL HOLSCHNEIDER; Fiscal Year: 2007
  9. AN IMPLANTABLE BOLUS INFUSION PUMP FOR THE NEUROSCIENCES
    DANIEL HOLSCHNEIDER; Fiscal Year: 2002
  10. AN IMPLANTABLE BOLUS INFUSION PUMP FOR THE NEUROSCIENCES
    DANIEL HOLSCHNEIDER; Fiscal Year: 2001

Detail Information

Publications237 found, 100 shown here

  1. ncbi Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2, Ohno Higashi, Osakasayama, Osaka 589 8511, Japan
    Neurochem Res 35:348-55. 2010
    ..In summary, edaravone treatment improved cerebral dysfunction following TBI, suggesting its potential as an effective clinical therapy...
  2. ncbi Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain
    Ning Zhang
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Tokyo 113 0033, Japan
    Stroke 36:2220-5. 2005
    ....
  3. ncbi Administration of edaravone, a free radical scavenger, during t-PA infusion can enhance early recanalization in acute stroke patients--a preliminary study
    Kazumi Kimura
    Department of Stroke Medicine, Kawasaki Medical School, Japan
    J Neurol Sci 313:132-6. 2012
    ..The aim of the present study was to investigate whether administration of edaravone during t-PA infusion can enhance early recanalization in acute stroke patients...
  4. ncbi Beneficial effects of edaravone, a novel antioxidant, in rats with dilated cardiomyopathy
    Somasundaram Arumugam
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    J Cell Mol Med 16:2176-85. 2012
    ..Our results suggest that edaravone ameliorated the progression of DCM by modulating oxidative and ER stress-mediated myocardial apoptosis and fibrosis...
  5. ncbi Edaravone mimics sphingosine-1-phosphate-induced endothelial barrier enhancement in human microvascular endothelial cells
    Kazuyoshi Omori
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Am J Physiol Cell Physiol 293:C1523-31. 2007
    ....
  6. pmc Free-radical scavenger edaravone treatment confers neuroprotection against traumatic brain injury in rats
    Guo hua Wang
    Department of Neuropharmacology, Institute of Nautical Medicine, Nantong University, Nantong, Jiangsu, China
    J Neurotrauma 28:2123-34. 2011
    ..The likely mechanism is via inhibiting oxidative stress, leading to a decreased inflammatory response and glial activation, and thereby reducing neuronal death and improving neurological function...
  7. ncbi Edaravone, a free radical scavenger, protects against retinal damage in vitro and in vivo
    Yuta Inokuchi
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu, Japan
    J Pharmacol Exp Ther 329:687-98. 2009
    ..These findings suggest that oxidative stress plays a pivotal role in retinal damage and that edaravone may be a candidate for the effective treatment of retinal diseases...
  8. ncbi Beyond neurological disease: new targets for edaravone (Review)
    Kiyoshi Kikuchi
    Department of Neurosurgery, Yame Public General Hospital, Yame 834 0034, Japan
    Int J Mol Med 28:899-906. 2011
    ....
  9. ncbi Effect of a free radical scavenger, edaravone, in the treatment of patients with aneurysmal subarachnoid hemorrhage
    Akira Munakata
    Department of Neurosurgery, Hirosaki University School of Medicine, Hirosaki, Japan
    Neurosurgery 64:423-8; discussion 428-9. 2009
    ..This study therefore investigated the effect of a new free radical scavenger, edaravone, in the treatment of patients with aneurysmal SAH...
  10. ncbi Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator
    Kenji Yagi
    Department of Neurosurgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Stroke 40:626-31. 2009
    ..Patients with acute infarct benefit from the neuroprotective drug edaravone, a free radical scavenger. We examined the mechanisms by which edaravone may help to suppress rtPA-induced brain hemorrhage...
  11. pmc Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro
    Brian J Lee
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Brain Res 1307:22-7. 2010
    ..Edaravone significantly ameliorated this response. These data suggest that free radical scavengers are effective in all cell types of the neurovascular unit, and should still be considered as a potential therapeutic approach for stroke...
  12. ncbi Dissociation and protection of the neurovascular unit after thrombolysis and reperfusion in ischemic rat brain
    Toru Yamashita
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Cereb Blood Flow Metab 29:715-25. 2009
    ....
  13. ncbi Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia
    Hideo Shichinohe
    Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Brain Res 1029:200-6. 2004
    ..These findings suggest that Edaravone salvages the boundary zone of infarct by scavenging reactive oxygen species especially in the neurons during permanent focal cerebral ischemia...
  14. ncbi Edaravone inhibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia
    Akira Ishikawa
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Neurosci Res 59:406-12. 2007
    ..These findings offer a partial explanation for the protective effect of edaravone on the development of brain edema in patients with acute ischemic stroke...
  15. ncbi Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4
    Kiyoshi Kikuchi
    Division of Laboratory and Vascular Medicine, Field of Cardiovascular and Respiratory Disorders, Department of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Biochem Biophys Res Commun 390:1121-5. 2009
    ..In light of observations that edaravone specifically inhibited AQP4 in a rat transient focal ischemia model, we propose that edaravone might reduce cerebral edema through the inhibition of AQP4 expression following cerebral infarction...
  16. ncbi The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells
    Kiyoshi Kikuchi
    Division of Laboratory and Vascular Medicine, Field of Cardiovascular and Respiratory Disorders, Department of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Science, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    J Pharmacol Exp Ther 329:865-74. 2009
    ..Furthermore, edaravone (3-30 microM) blocked HMGB1-triggered apoptosis in PC12 cells. Our findings suggest a novel neuroprotective mechanism for edaravone that abrogates the release of HMGB1...
  17. ncbi Efficacy of MCI-186, a free-radical scavenger and antioxidant, for resuscitation of nonbeating donor hearts
    Yasuhiro Kotani
    Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Thorac Cardiovasc Surg 133:1626-32. 2007
    ..In this study, the efficacy for resuscitation of nonbeating donor hearts of MCI-186, a free-radical scavenger and antioxidant, was investigated in a pig transplantation model...
  18. ncbi Effects of MCI-186 (edaravone), a novel free radical scavenger, upon experimental atherosclerosis in apolipoprotein E-deficient mice
    Taka Aki Okabe
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan
    Circ J 70:1216-9. 2006
    ..MCI-186 (3-methyl-1-phenyl-1-phyrazolin-5-one, edaravone) is a novel free radical scavenger, but it remains unclear whether free radical scavengers would be effective for the prevention of the disease...
  19. ncbi Electrocardiographic and biochemical evidence for the cardioprotective effect of antioxidants in acute doxorubicin-induced cardiotoxicity in the beagle dogs
    Yanfei Xin
    State Key Laboratory of Safety Evaluation for New Drugs, Center of Safety Evaluation, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang 310013, China
    Biol Pharm Bull 34:1523-6. 2011
    ..All these results confirm and extend previous observations in rats concerning the effectiveness of LBP or EDA against DOX-induced cardiomyopathy...
  20. ncbi C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation
    Yuji Miyazaki
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Arterioscler Thromb Vasc Biol 31:1124-32. 2011
    ..To investigate whether and how the endoplasmic reticulum (ER) stress-induced, CCAAT/enhancer-binding protein-homologous protein (CHOP)-mediated pathway regulates myocardial ischemia/reperfusion injury...
  21. ncbi Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury
    P Zhang
    Department of Anesthesiology, Second Affiliated Hospital of Xi an Jiaotong University School of Medicine, 157 West 5 road, Xi an, Shaanxi 710004, China
    Neuroscience 201:297-306. 2012
    ..05). These findings indicate that administration with edaravone, via repressing HIF-1α signaling pathway, inhibits SVZ neurogenesis in rats after cerebral ischemia-reperfusion injury...
  22. ncbi Long-term efficacy of edaravone in patients with acute myocardial infarction
    Kenichi Tsujita
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Circ J 70:832-7. 2006
    ..The effect of edaravone, a free radical scavenger, on long-term prognosis and its efficacy with regards to scavenging injurious free radicals in patients with acute myocardial infarction (AMI) was examined...
  23. ncbi Donor antioxidant strategy prolongs cardiac allograft survival by attenuating tissue dendritic cell immunogenicity(†)
    M Jurewicz
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital, Boston, MA, USA
    Am J Transplant 11:348-55. 2011
    ..These data for the first time establish a basis for donor anti-ischemic strategies, which in the ever-expanding marginal donor pools, can be instituted to promote engraftment...
  24. ncbi Scavenging free radicals improves endothelial dysfunction in human coronary arteries in vivo
    Jun ichi Oyama
    Department of Cardiovascular, Respiratory, and Geriatric Medicine, Kyushu University Hospital at Beppu and Medical Institute of Bioregulation, Kyushu University, Oita, Japan
    Heart Vessels 25:379-85. 2010
    ..Therefore, the current results suggest that scavenging free radicals has a beneficial effect for patients with coronary endothelial dysfunction...
  25. ncbi Edaravone, a free radical scavenger, in the treatment of idiopathic sudden sensorineural hearing loss with profound hearing loss
    Hajime Sano
    Department of Otolaryngology, Kitasato University, School of Medicine, 1 15 1 Kitasato Sagamihara, Kanagawa 228 8555, Japan
    Auris Nasus Larynx 37:42-6. 2010
    ..The aim of this study was to investigate whether edaravone could improve treatment result in idiopathic sudden sensorineural hearing loss (ISSHL) patients with severe hearing loss...
  26. ncbi Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils
    Yong Jian Jin
    Department of Neurosurgery, Kochi Medical School, Okohcho, Nankoku City, Kochi, Japan
    Neurosci Res 43:75-9. 2002
    ....
  27. ncbi Effect of the free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), on hypoxia-ischemia-induced brain injury in neonatal rats
    Tomoaki Ikeda
    Department of Obstetrics and Gynecology, Miyazaki Medical College, 5200 Kihara, Kiyotake cho, Miyazaki 889 16, Japan
    Neurosci Lett 329:33-6. 2002
    ..The administration of MCI-186 significantly attenuated damage, in a dose-dependent manner. These results indicate that MCI-186 is a promising candidate for the treatment of neonatal hypoxic-ischemic encephalopathy...
  28. pmc A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy?
    Paul A Lapchak
    Department of Neurology, Cedars Sinai Medical Center, 8730 Alden Drive, Thalians E216, Los Angeles, CA 90048, USA
    Expert Opin Pharmacother 11:1753-63. 2010
    ..With almost 17 years of edaravone clinical experience, a few adverse events--including acute renal failure--have been noted...
  29. ncbi Edaravone alleviates delayed neuronal death and long-dated cognitive dysfunction of hippocampus after transient focal ischemia in Wistar rat brains
    L Jiao
    Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China
    Neuroscience 182:177-83. 2011
    ....
  30. ncbi The lipophilic multifunctional antioxidant edaravone (radicut) improves behavior following embolic strokes in rabbits: a combination therapy study with tissue plasminogen activator
    Paul A Lapchak
    University of California San Diego, Department of Neuroscience, 9500 Gilman Drive MTF316, La Jolla, CA 92093 0624, USA
    Exp Neurol 215:95-100. 2009
    ..Edaravone can also be administered with a thrombolytic to improve behavior...
  31. ncbi Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury
    Hiroshi Yoshida
    Department of Internal Medicine, Division of General Medicine, Kashiwa Hospital, Jikei University School of Medicine, Kashiwa, Chiba, Japan
    CNS Drug Rev 12:9-20. 2006
    ..The combination therapy (a thrombolytic plus edaravone) is likely to target brain edema, reduce stroke death and improve the recovery from neurological deficits in stoke patients...
  32. ncbi Potent free radical scavenger, edaravone, suppresses oxidative stress-induced endothelial damage and early atherosclerosis
    Hang Xi
    Department of Geriatric Medicine, Kyorin University School of Medicine, Tokyo, Japan
    Atherosclerosis 191:281-9. 2007
    ..Effects of potent free radical scavenger, edaravone, on oxidative stress-induced endothelial damage and early atherosclerosis were investigated using animal models and cultured cells...
  33. ncbi Edaravone (radical scavenger) versus sodium ozagrel (antiplatelet agent) in acute noncardioembolic ischemic stroke (EDO trial)
    Yukito Shinohara
    Federation of National Public Service Personnel Mutual Aid Associations Tachikawa Hospital, Tokyo, Japan
    Cerebrovasc Dis 27:485-92. 2009
    ..We performed a postmarketing clinical trial to provide further reliable evidence concerning edaravone in patients with acute ischemic stroke...
  34. ncbi The radical scavenger edaravone prevents oxidative neurotoxicity induced by peroxynitrite and activated microglia
    Masahiro Banno
    Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo cho, Chikusa, Nagoya 464 8601, Japan
    Neuropharmacology 48:283-90. 2005
    ....
  35. ncbi Alkoxyl radical-scavenging activity of edaravone in patients with traumatic brain injury
    Kenji Dohi
    Department of Emergency and Critical Care Medicine, School of Medicine, Showa University, Tokyo, Japan
    J Neurotrauma 23:1591-9. 2006
    ..2-53.6 +/- 5.2; p < 0.01). Thus, edaravone can scavenge OR- and significantly reduce levels of these radicals in TBI patients. The novel ex vivo ESR method described here provides a valuable clinical measure of oxidative stress...
  36. ncbi Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats
    Shimon Amemiya
    Division of Neurology, Second Department of Internal Medicine, Nippon Medical School, 1 1 5, Sendagi, Bunkyo ku, Tokyo, 113 8603, Japan
    Eur J Pharmacol 516:125-30. 2005
    ..Edaravone shows an excellent neuroprotective effect against ischemia/reperfusion brain injury through a Bax/Bcl-2 dependent anti-apoptotic mechanism...
  37. ncbi Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia
    T Yamamoto
    Pharmaceuticals Laboratory I, Yokohama Research Center, Mitsubishi Chemical Corp, Aoba ku, Yokohama, Japan
    Brain Res 762:240-2. 1997
    ..Postischemic treatment with a free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), significantly reduced the increase in DHBA and suppressed delayed neuronal death in the hippocampal CA1 region...
  38. pmc Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons
    Wen Ji Yuan
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    BMC Neurosci 9:75. 2008
    ..In parallel, edaravone or saline was intravenously administered for PD model of rats receiving intrastriatal 6-OHDA lesion with subsequent behavioral and histological analyses...
  39. ncbi Edaravone prevents iNOS expression by inhibiting its promoter transactivation and mRNA stability in cytokine-stimulated hepatocytes
    Hideyuki Yoshida
    Department of Surgery, Kansai Medical University, Osaka 570 8506, Japan
    Nitric Oxide 18:105-12. 2008
    ..Edaravone may inhibit the induction of iNOS gene expression at steps of promoter transactivation and mRNA stabilization in cytokine-stimulated hepatocytes...
  40. ncbi Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum
    Toshiyuki Kawasaki
    Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871, Japan
    J Pharmacol Exp Ther 322:274-81. 2007
    ....
  41. ncbi Efficacy of edaravone, a free radical scavenger, for the treatment of acute lacunar infarction
    Masahiro Mishina
    The Department of Neurology, Neurological Institute, Nippon Medical School Chiba Hokusoh Hospital
    Neurol Med Chir (Tokyo) 45:344-8; discussion 348. 2005
    ..05) for a good outcome at 3 months. Higher baseline NIHSS score and higher age also adversely affected the outcome at 3 months (p < 0.005). Administration of edaravone improves the outcome of patients with lacunar infarction...
  42. ncbi The novel free radical scavenger, edaravone, increases neural stem cell number around the area of damage following rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Neurotox Res 16:378-89. 2009
    ....
  43. ncbi The antioxidant edaravone attenuates pressure overload-induced left ventricular hypertrophy
    Ikuko Tsujimoto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Hypertension 45:921-6. 2005
    ..These findings indicate that edaravone significantly attenuates pressure overload-induced cardiac hypertrophy mediated through its antioxidative function and subsequent inhibition of ASK1 signaling pathway...
  44. ncbi Edaravone attenuates white matter lesions through endothelial protection in a rat chronic hypoperfusion model
    Y Ueno
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Neuroscience 162:317-27. 2009
    ....
  45. ncbi Synthesis and antimicrobial activity of some new heterocycles incorporating antipyrine moiety
    Samir Bondock
    Department of Chemistry, Faculty of Science, Mansoura University, El gomhuria Street, ET 35516 Mansoura, Egypt
    Eur J Med Chem 43:2122-9. 2008
    ..The newly synthesized compounds were characterized by IR, 1H NMR and mass spectral studies. Representative compounds of the synthesized products were tested and evaluated as antimicrobial agents...
  46. ncbi Edaravone prevented deteriorated cardiac function after myocardial ischemia-reperfusion via inhibiting lipid peroxidation in rat
    Hiroshi Yagi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    J Cardiovasc Pharmacol 46:46-51. 2005
    ....
  47. ncbi Edaravone attenuates hydroxyl radical stress and augmented angiotensin II response in diabetic rats
    Anuj Kumar Saini
    Torrent Research Center, Gandhinagar, Gujarat, India
    Pharmacol Res 54:6-10. 2006
    ..From our results we infer that hydroxyl radical stress augments Ang II response in diabetic rat thoracic aorta and edaravone could be an ideal antioxidant adjuvant in the therapy of diabetic vascular complications...
  48. ncbi Cardioprotective effect of edaravone against ischaemia-reperfusion injury in the rabbit heart before, during and after reperfusion treatment
    A Fukuda
    Department of Cardiology, Tokyo Medical University Kasumigaura Hospital, Ami, Ibaraki, Japan
    J Int Med Res 34:475-84. 2006
    ....
  49. ncbi Effects of edaravone on singlet oxygen released from activated human neutrophils
    Piyanart Sommani
    Institute of Advanced Energy, Kyoto University, Uji 611 0011, Japan
    J Pharmacol Sci 103:117-20. 2007
    ..3 microM, while the IC(50) of histidine was approximately 1 mM. This (1)O2 scavenging activity of edaravone might be involved in its curative effects on acute brain infarction...
  50. ncbi Inhibitory effects of edaravone on the production of tumor necrosis factor-alpha in the isolated heart undergoing ischemia and reperfusion
    Shunji Onimaru
    Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Heart Vessels 21:108-15. 2006
    ....
  51. ncbi Edaravone, a radical scavenger, inhibits mitochondrial permeability transition pore in rat brain
    Yuko Takayasu
    Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan
    J Pharmacol Sci 103:434-7. 2007
    ..These results suggest that edaravone inhibits opening of mitochondrial PTP in the brain, and they imply that inhibition of mitochondrial PTP may account for the neuroprotective effect of edaravone...
  52. ncbi Hydroxyl radical mediates the augmented angiotensin II responses in thoracic aorta of spontaneously hypertensive rats
    Aaishwarya B Deshmukh
    Department of Pharmacology, S K Patel College of Pharmaceutical Education and Research, Kherva, India
    Pharmacology 79:122-8. 2007
    ..To investigate the role of hydroxyl radical in augmented angiotensin II (Ang II) responses in the thoracic aorta of spontaneously hypertensive rats (SHR)...
  53. pmc Protective effect of edaravone against hypoxia-reoxygenation injury in rabbit cardiomyocytes
    Masahiro Yamawaki
    Department of Cardiovascular Medicine, Tottori University Faculty of Medicine, Japan
    Br J Pharmacol 142:618-26. 2004
    ....
  54. ncbi Edaravone protects against hypoxia/ischemia-induced endoplasmic reticulum dysfunction
    Xin Qi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    J Pharmacol Exp Ther 311:388-93. 2004
    ..These results demonstrated a novel action of edaravone that can protect against ER dysfunction in cerebral ischemia...
  55. ncbi Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum
    Toshiyuki Kawasaki
    Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871, Japan
    Eur J Pharmacol 542:92-9. 2006
    ..This study also suggests that methamphetamine activates microglia in a radical-independent mechanism...
  56. ncbi MCI-186 (edaravone), a novel free radical scavenger, protects against acute autoimmune myocarditis in rats
    Masaomi Nimata
    Dept of Cardiovascular Medicine, Graduate School of Medicine, Kyoto Univ, 54 Kawaracho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Am J Physiol Heart Circ Physiol 289:H2514-8. 2005
    ..MCI-186 protects against acute EAM in rats associated with scavenging hydroxyl free radicals, resulting in the suppression of autoimmune-mediated myocardial damage associated with reduced oxidative stress state...
  57. ncbi Contractile responses to reactive oxygen species in the canine basilar artery in vitro: selective inhibitory effect of MCI-186, a new hydroxyl radical scavenger
    M Tosaka
    Department of Neurosurgery, Gunma University School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Acta Neurochir (Wien) 144:1305-10; discussion 1310. 2002
    ....
  58. ncbi Synthesis, antitumor, cytotoxic and antioxidant evaluation of some new pyrazolotriazines attached to antipyrine moiety
    M A Metwally
    Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt
    Eur J Med Chem 56:254-62. 2012
    Iminopropanehydrazonoyl cyanide 4 was achieved upon reaction of antipyrine diazonium salt 2 with 3-iminobutanenitrile (3) in EtOH/AcONa. 3-Aminopyrazole derivative 5 was obtained upon reaction of 4 with hydrazine hydrate...
  59. ncbi A hypothesis: Edaravone exert cardioprotection partly via modulation of adiponectin
    Haifeng Pei
    Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, Xi an 710032, China
    Med Hypotheses 79:141-2. 2012
    ..So we hypothesize that edaravone plays a role in cardioprotection partly through modulation of adiponectin level by suppression of TNF-α...
  60. ncbi Edaravone, a free radical scavenger, ameliorates experimental autoimmune encephalomyelitis
    Masayuki Moriya
    Department of Neurology D 4, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Neurosci Lett 440:323-6. 2008
    ..A reduction of both the cellular infiltration and the expression of iNOS may therefore underlie the mechanisms of the beneficial effect of edaravone on EAE...
  61. ncbi Involvement of AMPK and MAPK signaling during the progression of experimental autoimmune myocarditis in rats and its blockade using a novel antioxidant
    Somasundaram Arumugam
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City 956 8603, Japan
    Exp Mol Pathol 93:183-9. 2012
    ..In viewing these results, we can suggest that along with MAPK, AMPK signaling also plays a crucial role in the progression of EAM and it can be effectively blocked by the treatment with a novel antioxidant, edaravone...
  62. ncbi Metal-based biologically active agents: Synthesis, characterization, antibacterial and antileukemia activity evaluation of Cu(II), V(IV) and Ni(II) complexes with antipyrine-derived compounds
    Tudor Rosu
    Inorganic Chemistry Department, Faculty of Chemistry, University of Bucharest, 23 Dumbrava Rosie Street, 020462 Bucharest, Romania
    Eur J Med Chem 45:774-81. 2010
    ..with Schiff bases obtained through the condensation of 4-amino-1,5-dimethyl-2-phenyl-1H-3-pyrazol-3(2H)-one (antipyrine) with 2-hydroxybenzaldehyde, 4-hydroxy-5-methoxyisophthalaldehyde and 4,5-dihydroxyisophalaldehyde respectively...
  63. ncbi In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia in mice
    Ning Liu
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Brain Res 1397:66-75. 2011
    ....
  64. ncbi Effect of edaravone on plasma monocyte chemoattractant protein-1 levels in patients with acute myocardial infarction
    Yoshinori Nakamura
    Fukuoka Tokushukai Medical Center, 4 5 Sukukita, Kasuga, Fukuoka 816 0864, Japan
    J Cardiol 54:416-24. 2009
    ..We have recently demonstrated that the administration of edaravone before reperfusion attenuated reperfusion injury in patients with acute myocardial infarction (AMI)...
  65. ncbi Edaravone Mitsubishi-Tokyo
    R Tabrizchi
    Memorial University of Newfoundland, Faculty of Medicine, Basic Medical Sciences, Health Sciences Centre, St John s, NF, A1B 3V6, Canada
    Curr Opin Investig Drugs 1:347-54. 2000
    ..The compound blocks the action of the lipoperoxide, 15-HPETE, which normally increases with age and may be associated with neurodegeneration...
  66. ncbi Edaravone, a hydroxyl radical scavenger, ameliorates the severity of pulmonary hypertension in a porcine model of neonatal sepsis
    Sachiko Yamaguchi
    Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Tohoku J Exp Med 223:235-41. 2011
    ..In all animals, mPAP/mABP at 6 h correlated with serum levels of TNFα at 1, 3, and 6 h. These findings suggest that edaravone ameliorates the severity of pulmonary hypertension in a neonatal sepsis model by reducing serum TNFα levels...
  67. ncbi The therapeutic efficacy of edaravone in extensively burned rats
    Takeo Koizumi
    Department of Emergency and Critical Care Medicine, Medical School of Kyorin University, Tokyo, Japan
    Arch Surg 141:992-5. 2006
    ..However, the effect of edaravone against extensive burn injury has not been tested. Objected To evaluate whether edaravone can reduce free radical precursors in a 30% burn model in rats...
  68. ncbi Edaravone prevents bowel infarction after acute superior mesenteric artery thromboembolism using autologous fibrin clots in a rabbit model
    A Sonoda
    Department of Radiology, Shiga University of Medical Science, Setatsukinowa cho, Otsu, Shiga 520 2192, Japan
    Br J Radiol 82:711-5. 2009
    ..An increase in survival rate requires improvements in evaluation methods to enable identification of ischaemic areas...
  69. ncbi Neuroprotection and enhanced recovery with edaravone after acute spinal cord injury in rats
    Souichi Ohta
    Department of Orthopaedic Surgery, Kyoto University, Kyoto, Japan
    Spine (Phila Pa 1976) 30:1154-8. 2005
    ..The effect of edaravone, a novel free radical scavenger, was assessed functionally and histologically using a rat spinal cord contusion model...
  70. ncbi Temporal effects of edaravone, a free radical scavenger, on transient ischemia-induced neuronal dysfunction in the rat hippocampus
    Hiroshi Otani
    Department of Neuropharmacology, Hokkaido Graduate University School of Medicine, Sapporo 060 8638, Japan
    Eur J Pharmacol 512:129-37. 2005
    ....
  71. ncbi Edaravone, a free radical scavenger, is effective on neuropathic pain in rats
    Yan Fei Mao
    Department of Anesthesiology, Changhai Hospital, Second Military Medical University, 800 Xiangyin Rd, Shanghai, 200433, PR China
    Brain Res 1248:68-75. 2009
    ....
  72. ncbi MCI-186: further histochemical and biochemical evidence of neuroprotection
    T W Wu
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto Western Hospital, Canada
    Life Sci 67:2387-92. 2000
    ..05). Our data supported our contention that MCI-186 has potent anti-stroke effect with antioxidant activities...
  73. ncbi Edaravone ameliorates oxidative stress associated cholinergic dysfunction and limits apoptotic response following focal cerebral ischemia in rat
    Ajmal Ahmad
    Department of Medical Elementology and Toxicology Fund for the Improvement of Science and Technology DST and Special Assistance Programme UGC Sponsored, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi, India
    Mol Cell Biochem 367:215-25. 2012
    ..We theorized that Edv is among the pharmacological agents that reduce free radicals and its associated cholinergic dysfunction and apoptotic damage and have been found to limit the extent of brain damage following stroke...
  74. ncbi Membrane permeability and antipyrine absorption in a rat model of ischemic colitis
    Kenjiro Koga
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho 3, Kanagawa machi, Kanazawa 920 1181, Japan
    Int J Pharm 286:41-52. 2004
    The aim of this study was to determine whether the duration of ischemia affects antipyrine absorption in the large intestine...
  75. ncbi Protective effects of edaravone against ischemia-induced facial palsy
    Taizo Takeda
    Department of Otolaryngology, Head and Neck Surgery, Kochi Medical School, Kohasu, Oko cho, Nankoku, Kochi, Japan
    Auris Nasus Larynx 35:321-7. 2008
    ..The protective effect of edaravone, an inhibitor of reactive oxygen species (ROS), against the development of ischemia-induced facial palsy was investigated...
  76. ncbi [Research and development of the free radical scavenger edaravone as a neuroprotectant]
    Toshiaki Watanabe
    Mitsubishi Pharma Corporation, Sales and Marketing Division, 2 5 6 Awaji machi, Chuo Ku, Osaka 541 0047, Japan
    Yakugaku Zasshi 124:99-111. 2004
    ..We hope that edaravone represents a promising neuroprotectant for drug therapy in acute cerebral ischemia...
  77. ncbi Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils
    Feng Lu
    Department of Neurobiology, Kagawa University Faculty of Medicine, Miki, Japan
    Neurosci Lett 506:28-32. 2012
    ..These findings suggest that edaravone inhibits oxidative stress and attenuates neuronal damage induced by transient forebrain ischemia in gerbils and which may contribute to improvements in behavioral deficits...
  78. ncbi [Future neuroprotective strategies in the post-thrombolysis era--neurovascular unit protection and vascular endothelial protection]
    Tatsushi Kamiya
    Department of Neurology, Kamiya Iin
    Rinsho Shinkeigaku 51:305-15. 2011
    ..Therefore, we review and describe the future neuroprotective strategies in the post-thrombolysis era...
  79. ncbi Edaravone for acute ischaemic stroke
    Shejun Feng
    a Department of Neurology, West China Hospital, Sichuan University, Chengdu, China, b Second Department of Neurology, Central Hospital, Handan, China
    Cochrane Database Syst Rev 12:CD007230. 2011
    ..Edaravone is a neuroprotective agent that has been widely used in China, and several studies have suggested that it may be beneficial in acute ischaemic stroke...
  80. ncbi Neuroprotective effects of edaravone, a free radical scavenger, on the rat hippocampus after pilocarpine-induced status epilepticus
    T Kamida
    Department of Neurosurgery, Oita University, Faculty of Medicine, 1 1 Idaigaoka, Hasama machi, Oita 879 5593, Japan
    Seizure 18:71-5. 2009
    ..The neuroprotective effects of edaravone on pilocarpine-induced seizures in rats were investigated...
  81. ncbi A combined treatment for acute larger lacunar-type infarction
    Yasumasa Yamamoto
    Department of Neurology, Kyoto Second Red Cross Hospital, Kyoto, Japan
    J Stroke Cerebrovasc Dis 20:387-94. 2011
    ..The novel combined treatment approach was safe and effective in improving functional outcome in acute LLI, but not effective in preventing PMD...
  82. ncbi Normalization by edaravone, a free radical scavenger, of irradiation-reduced endothelial nitric oxide synthase expression
    Xiao Hong Zhang
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Eur J Pharmacol 476:131-7. 2003
    ..We thus assume that oxygen-free radicals may be closely related to the irradiation-induced derangement of the eNOS gene regulation...
  83. ncbi Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion
    Kazunori Toyoda
    Department of Cerebrovascular Disease and Clnical Research Institute, National Kyushu Medical Center, Chuo, Fukuoka, Japan
    J Neurol Sci 221:11-7. 2004
    ..The agent has been recently in commercial use for acute ischemic stroke patients. In this study, we investigated the therapeutic effect of edaravone on severe carotid-territorial stroke...
  84. ncbi Efficacy of edaravone in cardioembolic stroke
    Yuichiro Inatomi
    Stroke Center, Saiseikai Kumamoto Hospital, Chikami
    Intern Med 45:253-7. 2006
    ..We investigated the efficacy of edaravone in patients with cardioembolic stroke...
  85. ncbi Reactive oxygen species generated by mitochondrial injury in human brain microvessel endothelial cells
    Yoshiaki Itoh
    Department of Neurology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Clin Hemorheol Microcirc 34:163-8. 2006
    ..05). These data show that chemical hypoxia with normal concentration of oxygen in the medium induced free radicals generation in HBEC. Importance of endothelial mitochondria as a source of free radicals after reperfusion is suggested...
  86. ncbi An antioxidant treatment potentially protects myocardial energy metabolism by regulating uncoupling protein 2 expression in a chronic beta-adrenergic stimulation rat model
    Makoto Ishizawa
    Second Department of Internal Medicine, Kagawa University School of Medicine, Miki, Kita, Kagawa, 761 0793, Japan
    Life Sci 78:2974-82. 2006
    ..Adequate regulation of UCP2 expression through artificial reduction of oxidative stress may play an important role in protection of the myocardial energy metabolism...
  87. ncbi Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage
    Takehiro Nakamura
    Department of Neurobiology, Kagawa University Faculty of Medicine, 1750 1 Ikenobe, Miki, Kagawa 761 0793, Japan
    Stroke 39:463-9. 2008
    ..Our previous studies have demonstrated that oxidative DNA injury occurs in the brain after intracerebral hemorrhage (ICH). We therefore examined whether edaravone, a free-radical scavenger, could reduce ICH-induced brain injury...
  88. ncbi Does functional outcome in acute ischaemic stroke patients correlate with the amount of free-radical scavenger treatment? A retrospective study of edaravone therapy
    Yoshiko Unno
    Department of Neurology, Kawakita General Hospital, Tokyo, Japan
    Clin Drug Investig 30:143-55. 2010
    ..Edaravone is a free-radical scavenger that has been widely used for acute ischaemic stroke in Japan. However, the optimal total dosage of edaravone has not been established...
  89. ncbi Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers
    A Richard Green
    Global Discovery CNS and Pain Control, AstraZeneca R and D Charnwood, Bakewell Road, Loughborough LE11 5RH, UK
    Curr Drug Targets CNS Neurol Disord 4:109-18. 2005
    ....
  90. ncbi Synthesis of some triazolyl-antipyrine derivatives and investigation of analgesic activity
    G Turan-Zitouni
    Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 26470, Eskisehir, Turkey
    Eur J Med Chem 36:685-9. 2001
    The synthesis of some triazolyl-antipyrine derivatives starting from 4-chloroacetamidoantipyrine and 3-(aryloxyalkyl)-4-ethyl/phenyl-5-mercapto-1,2,4-triazoles is described...
  91. ncbi A case report of acute renal failure and fulminant hepatitis associated with edaravone administration in a cerebral infarction patient
    Masanori Abe
    Department of Medicine, Division of Nephrology and Endocrinology, Nihon University, School of Medicine, Tokyo, Japan
    Ther Apher Dial 11:235-40. 2007
    ..It is suggested that blood purification is effective in inducing remission in patients with complications due to edaravone treatment...
  92. ncbi Repeated edaravone treatment reduces oxidative cell damage in rat brain induced by middle cerebral artery occlusion
    Yorihiro Yamamoto
    School of Bioscience and Biotechnology, Tokyo University of Technology, Hachioji, Tokyo, Japan
    Redox Rep 14:251-8. 2009
    ..Repeated treatment suppressed the percentage 18:1 increment, while the single administration did not, which is consistent with the limited efficacy of single administration...
  93. ncbi Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice
    Hidefumi Ito
    Department of Neurology, Kansai Medical University, Moriguchi, Osaka, Japan
    Exp Neurol 213:448-55. 2008
    ..These favorable actions might be attributable to the yet unidentified mechanism responsible for reducing the deposition of mutant SOD1...
  94. ncbi Efficacy of the free radical scavenger, edaravone, for motor palsy of acute lacunar infarction
    Yasuyuki Ohta
    Ota Memorial Hospital, Fukuyama, Japan
    Intern Med 48:593-6. 2009
    ..This study investigated the effect of edaravone on the outcome of patients with acute lacunar infarction...
  95. pmc Edaravone, a free radical scavenger, mitigates both gray and white matter damages after global cerebral ischemia in rats
    Kozue Kubo
    Department of Anesthesiology, Kansai Medical University, Osaka, Japan
    Brain Res 1279:139-46. 2009
    ..Our results show that axonal damage develops slower than perikaryal damage and that edaravone can protect both gray and white matter after CAR in rats...
  96. ncbi Edaravone protects against MPP+ -induced cytotoxicity in rat primary cultured astrocytes via inhibition of mitochondrial apoptotic pathway
    Hui Chen
    Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, China
    J Neurochem 106:2345-52. 2008
    ..The antiapoptosis effects of Eda on astrocytes may provide a new perspective on neuroprotective therapy...
  97. ncbi Short-term administration of a new free radical scavenger, edaravone, is more effective than its long-term administration for the treatment of neonatal hypoxic-ischemic encephalopathy
    Jesmin I Noor
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Stroke 36:2468-74. 2005
    ..We examined the effect of edaravone on the optimal duration of treatment, the long-term effect on the brain, and the effect on learning and memory disability in a rat model of neonatal hypoxic-ischemic encephalopathy...
  98. ncbi Nitric oxide-induced apoptosis in cultured rat astrocytes: protection by edaravone, a radical scavenger
    Toshiyuki Kawasaki
    Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan
    Glia 55:1325-33. 2007
    ....
  99. pmc The use of microdialysis for the study of drug kinetics: some methodological considerations illustrated with antipyrine in rat frontal cortex
    P N Patsalos
    Pharmacology and Therapeutics Unit, University Department of Clinical Neurology, Queen Square, London
    Br J Pharmacol 115:503-9. 1995
    1. The neuropharmacokinetics of antipyrine, a readily dialysable drug, in rat frontal cortex were studied and the effect of sampling time and contribution of period sampling and dialysate dead volume investigated in relation to tmax, Cmax,..
  100. ncbi Improvement of postischemic dopaminergic dysfunction by edaravone, a free radical scavenger
    Yoshinori Akiyama
    Department of Neurosurgery, Tenri Hospital, Nara, and Department of Cellular Pharmacology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Pharmacol Sci 104:99-102. 2007
    ..These results suggest that free radicals produced during ischemia play more important roles in ischemia/reperfusion-induced dysfunctions of dopaminergic neurons...
  101. ncbi Transplacental transfer of acrylamide and glycidamide are comparable to that of antipyrine in perfused human placenta
    Kirsi Annola
    Department of Pharmacology and Toxicology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Toxicol Lett 182:50-6. 2008
    ..Placentas were collected immediately after delivery and kept physiologically functional as confirmed by antipyrine kinetics, glucose consumption and leak from fetal to maternal circulation...

Research Grants17

  1. MASS SPECTROMETER SYSTEM AND ACCESSORIES
    ALAN NIES; Fiscal Year: 1990
    ..This proposal is to investigate the pharmacokinetics of model compounds, lidocaine and antipyrine, in burn patients...
  2. Brain serotonin and angiotensin II systems in migraine
    JOSE TERRON; Fiscal Year: 2007
    ..reactivity will be assessed by laser- Doppler flowmetry (cortical blood flow) and the 4-iodo-[N-methyl-14C]-antipyrine method (regional cerebral blood flow)...
  3. ABNORMAL METABOLISM IN ALCOHOLIC CIRRHOSIS
    Rajender Chawla; Fiscal Year: 1993
    ..Patients will also undergo galactose clearance and antipyrine clearance tests, and computerized tomography scan of their liver and their biochemical package-fasting plasma ..
  4. SEVERE DIFFUSE TRAUMATIC BRAIN INJURY
    P David Adelson; Fiscal Year: 2001
    ..by performing serial assessments of functional outcome (cognition and motor) and determining CBF using iodo[14C] antipyrine (14C-IAP) autoradiography...
  5. FETAL NUTRIENT THERAPY: EFFECTS ON GROWTH RETARDATION
    Valerie Charlton; Fiscal Year: 1992
    ..Maternal and fetal blood flow will be determined prospectively with an antipyrine technique; flow distribution will be determined with radiolabelled microspheres...
  6. BODY COMPOSITION IN NEONATES OF DIABETIC MOTHERS
    YVES BRANS; Fiscal Year: 1980
    ..We propose to better document body composition variables (antipyrine space, corrected bromide space, intracellular water, subcutaneous fat, fingernail nitrogen content) in neonates ..
  7. PET Behavioral Brain Mapping In Freely Moving Animals
    DANIEL HOLSCHNEIDER; Fiscal Year: 2006
    ..Such knowledge may provide the basis of an improved integration of a functional brain anatomy in the context of mental disorders. ..
  8. Microinfusion Pump For Animal Functional Brain Mapping
    DANIEL HOLSCHNEIDER; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  9. AN IMPLANTABLE BOLUS INFUSION PUMP FOR THE NEUROSCIENCES
    DANIEL HOLSCHNEIDER; Fiscal Year: 2002
    ....
  10. AN IMPLANTABLE BOLUS INFUSION PUMP FOR THE NEUROSCIENCES
    DANIEL HOLSCHNEIDER; Fiscal Year: 2001
    ....
  11. Estrogen and the Aging Blood Brain Barrier
    OAK CHI; Fiscal Year: 2002
    ..The information obtained from our study will be crucially important for the clinical application of estrogen therapy for stroke as well as understanding the pathophysiology of age related cerebrovascular changes. ..
  12. Mechanisms of Axonal Sprouting After Stroke
    STANLEY CARMICHAEL; Fiscal Year: 2007
    ..These experiments will identify neuronal growth programs after stroke, and Iocal inhibitory molecules, and provide an understanding of the mechanisms of regeneration in the adult brain. ..
  13. PGP Regulation of Antipsychotic Exposure and Effects
    C Devane; Fiscal Year: 2008
    ..The results of this research will provide support for translational studies in humans to refine treatment guidelines for the use of this class of medications in severely mentally ill patients. ..
  14. Pycnogenol for Treatment of Arm Lymphedema
    Paul Hutson; Fiscal Year: 2004
    ..In summary, the successful completion of this research can be expected to provide an alternative therapy and new instruments for treating and measuring lymphedema. ..
  15. Pharmacogenetics of Methadone
    C Devane; Fiscal Year: 2003
    ..This study will form the basis for subsequent studies which should provide a more rational basis for dosing of methadone in pregnant addicts. ..
  16. Mechanisms of Neuronal Regeneration after Stroke in a Novel Neurovascular Niche
    STANLEY THOMAS CARMICHAEL; Fiscal Year: 2010
    ..An understanding of the molecules that promote this neural stem cell response after stroke will help develop novel therapies to promote replacement of brain cells in this disease. ..
  17. MRI Measure of Blood Brain Barrier Permeability
    James Ewing; Fiscal Year: 2006
    ..We will demonstrate these measures in 9L tumors in Fischer 344 rats, and in reperfused ischemic infarction in Wistar rats. ..