oxazolone

Summary

Summary: Immunologic adjuvant and sensitizing agent.

Top Publications

  1. ncbi CD4+ Th1 and CD8+ type 1 cytotoxic T cells both play a crucial role in the full development of contact hypersensitivity
    B Wang
    Division of Dermatology, Sunnybrook and Women s College Health Science Centre, Toronto, Ontario, Canada
    J Immunol 165:6783-90. 2000
  2. ncbi B cells are not required for T cell priming in low zone tolerance to contact allergens and contact hypersensitivity
    Wolfgang Seidel-Guyenot
    Department of Dermatology, University of Mainz, Mainz, Germany
    Eur J Immunol 34:3082-90. 2004
  3. ncbi Essential role of CCR6 in directing activated T cells to the skin during contact hypersensitivity
    Timothy J Paradis
    Department of Immunology, Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    J Invest Dermatol 128:628-33. 2008
  4. ncbi 3,3'-Diindolylmethane alleviates oxazolone-induced colitis through Th2/Th17 suppression and Treg induction
    Zhen Huang
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China
    Mol Immunol 53:335-44. 2013
  5. ncbi Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells
    Frank Heller
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 17:629-38. 2002
  6. ncbi Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production
    Ashley J Fowler
    Department of Dermatology, University of California, San Francisco, USA
    J Invest Dermatol 120:246-55. 2003
  7. ncbi Effect of peptide fragment size on the propensity of cyclization in collision-induced dissociation: oligoglycine b(2)-b(8)
    Xian Chen
    Department of Chemistry, University of Florida, Gainesville, Florida 32611, USA
    J Am Chem Soc 131:18272-82. 2009
  8. ncbi IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis
    Stefan Fichtner-Feigl
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 CRC 5W3864, 10 Center Drive, Bethesda, Maryland 20892, USA
    Nat Med 12:99-106. 2006
  9. ncbi T cell- and B cell-independent adaptive immunity mediated by natural killer cells
    Jacqueline G O'Leary
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:507-16. 2006
  10. ncbi Reduced oxazolone-induced skin inflammation in MAPKAP kinase 2 knockout mice
    Anne T Funding
    Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark
    J Invest Dermatol 129:891-8. 2009

Detail Information

Publications217 found, 100 shown here

  1. ncbi CD4+ Th1 and CD8+ type 1 cytotoxic T cells both play a crucial role in the full development of contact hypersensitivity
    B Wang
    Division of Dermatology, Sunnybrook and Women s College Health Science Centre, Toronto, Ontario, Canada
    J Immunol 165:6783-90. 2000
    ..Mice lacking either CD4(+) or CD8(+) T cells demonstrated depressed CHS responses to dinitrofluorobenzene and oxazolone compared with wild-type C57BL/6 mice...
  2. ncbi B cells are not required for T cell priming in low zone tolerance to contact allergens and contact hypersensitivity
    Wolfgang Seidel-Guyenot
    Department of Dermatology, University of Mainz, Mainz, Germany
    Eur J Immunol 34:3082-90. 2004
    ....
  3. ncbi Essential role of CCR6 in directing activated T cells to the skin during contact hypersensitivity
    Timothy J Paradis
    Department of Immunology, Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    J Invest Dermatol 128:628-33. 2008
    ..Here, we report that mice sensitized with the hapten oxazolone had increased numbers of CCR6+ T cells in the draining lymph nodes...
  4. ncbi 3,3'-Diindolylmethane alleviates oxazolone-induced colitis through Th2/Th17 suppression and Treg induction
    Zhen Huang
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China
    Mol Immunol 53:335-44. 2013
    ..The therapeutic effects of DIM were studied in an oxazolone-induced colitis model...
  5. ncbi Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells
    Frank Heller
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 17:629-38. 2002
    b>Oxazolone colitis (OC) is an experimental colitis that has a histologic resemblance to human ulcerative colitis...
  6. ncbi Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production
    Ashley J Fowler
    Department of Dermatology, University of California, San Francisco, USA
    J Invest Dermatol 120:246-55. 2003
    ..Both ear thickness and weight increased (approximately 1.5-fold) in the oxazolone-induced allergic dermatitis model, and 22ROH and GW3965 reduced inflammation by approximately 50% and ..
  7. ncbi Effect of peptide fragment size on the propensity of cyclization in collision-induced dissociation: oligoglycine b(2)-b(8)
    Xian Chen
    Department of Chemistry, University of Florida, Gainesville, Florida 32611, USA
    J Am Chem Soc 131:18272-82. 2009
    ..insights from these results yield compelling evidence that smaller b(n) fragments (n = 2, 3) exclusively adopt oxazolone-type structures, whereas a mixture of oxazolone and macrocycle b fragment structures are formed for midsized b(n)..
  8. ncbi IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis
    Stefan Fichtner-Feigl
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 CRC 5W3864, 10 Center Drive, Bethesda, Maryland 20892, USA
    Nat Med 12:99-106. 2006
    ..In vivo, we found that prevention of IL-13Ralpha(2) expression reduced production of TGF-beta(1) in oxazolone-induced colitis and that prevention of IL-13Ralpha(2) expression, Il13ra2 gene silencing or blockade of IL-..
  9. ncbi T cell- and B cell-independent adaptive immunity mediated by natural killer cells
    Jacqueline G O'Leary
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:507-16. 2006
    ..T cells and B cells demonstrated substantial contact hypersensitivity responses to 2,4-dinitrofluorobenzene and oxazolone. Those responses were adaptive in nature, as they persisted for at least 4 weeks and were elicited only by ..
  10. ncbi Reduced oxazolone-induced skin inflammation in MAPKAP kinase 2 knockout mice
    Anne T Funding
    Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark
    J Invest Dermatol 129:891-8. 2009
    ..This study investigates for the first time the role of MK2 in skin inflammation using the model of oxazolone-induced acute allergic contact dermatitis in mice...
  11. ncbi Oxidative DNA damage associated with combination of guanine and superoxide radicals and repair mechanisms via radical trapping
    Richard Misiaszek
    Chemistry Department and Radiation and Solid State Laboratory, New York University, New York, New York 10003 5180, USA
    J Biol Chem 279:32106-15. 2004
    ..The mechanistic aspects of the radical reactions that either regenerate undamaged guanine in DNA or lead to oxidatively modified guanine bases are discussed...
  12. ncbi Immune sensitization in the skin is enhanced by antigen-independent effects of IgE
    Paul J Bryce
    Division of Immunology, Children s Hospital, Boston, MA 02115 USA
    Immunity 20:381-92. 2004
    ..We speculate that levels of IgE normally present in mice favor immune sensitization via antigen-independent but FcepsilonRI-dependent effects on mast cells...
  13. ncbi FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions
    Carolin Daniel
    First Department of Internal Medicine, JWG University of Frankfurt am Main, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Mol Immunol 44:3305-16. 2007
    ..Therefore, we studied the effect of FTY720 in T helper type (Th2)-mediated oxazolone-induced colitis in mice...
  14. ncbi Genetic ablation of PARP-1 protects against oxazolone-induced contact hypersensitivity by modulating oxidative stress
    Attila Brunyánszki
    Department of Medical Chemistry, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
    J Invest Dermatol 130:2629-37. 2010
    ..CHS) reaction is a form of delayed-type of hypersensitivity caused by contact allergens such as oxazolone (OXA)...
  15. pmc Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens
    Tiffany C Scharschmidt
    Department of Dermatology, Dermatology Service, Veterans Affairs Medical Center, University of California, San Francisco, Calif 94121, USA
    J Allergy Clin Immunol 124:496-506, 506.e1-6. 2009
    ..Yet additional acquired stressors might be necessary because the same mutations can result in a noninflammatory disorder, ichthyosis vulgaris...
  16. pmc Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges
    Mao Qiang Man
    Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 128:79-86. 2008
    ..Here, 9-10 challenges with oxazolone (Ox) to hairless mice also produced a chronic Th2-like HR...
  17. pmc Exacerbation of oxazolone colitis by infection with the helminth Hymenolepis diminuta: involvement of IL-5 and eosinophils
    Arthur Wang
    Gastrointestinal Research Group, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
    Am J Pathol 177:2850-9. 2010
    Substantial data show that infection with helminth parasites ameliorates colitis; however, oxazolone-induced colitis is exaggerated in mice infected with the tapeworm, Hymenolepis diminuta...
  18. ncbi Effect of ginsenoside Rb1 and compound K in chronic oxazolone-induced mouse dermatitis
    Yong Wook Shin
    College of Pharmacy, Kyung Hee University, 1, Hoegi, Dongdaemun ku, Seoul 130 701, South Korea
    Int Immunopharmacol 5:1183-91. 2005
    ..program to discover antipsoriatic agents from natural products, ginseng was found to show inhibitory activity in oxazolone-induced mouse ear dermatitis...
  19. pmc IRMPD spectroscopy shows that AGG forms an oxazolone b2+ ion
    Sung Hwan Yoon
    Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
    J Am Chem Soc 130:17644-5. 2008
    ..experimental spectrum for the b(2)(+) ion from protonated AGG matches best to the theoretical spectrum for an oxazolone structure protonated on the ring nitrogen...
  20. ncbi Spectroscopic evidence for an oxazolone structure of the b(2) fragment ion from protonated tri-alanine
    Jos Oomens
    FOM Institute for Plasma Physics Rijnhuizen, Nieuwegein, The Netherlands
    J Am Soc Mass Spectrom 20:334-9. 2009
    ..Instead, comparison of the IRMPD spectrum of b(2)(+) to spectra predicted by density functional theory provides compelling evidence for an oxazolone structure protonated at the oxazolone N-atom.
  21. pmc Mast cells regulate the magnitude and the cytokine microenvironment of the contact hypersensitivity response
    M Ursula Norman
    Immunology Research Group, University of Calgary, Calgary, AB, T2N 4N1, Canada
    Am J Pathol 172:1638-49. 2008
    ..CS in both W/Wv mast cell-deficient and wild-type mice in response to different immunizing doses of hapten (oxazolone)...
  22. ncbi Anti-inflammatory effect of 1-methylnicotinamide in contact hypersensitivity to oxazolone in mice; involvement of prostacyclin
    Krzysztof Bryniarski
    Department of Immunology Jagiellonian University Medical College, Krakow, Poland
    Eur J Pharmacol 578:332-8. 2008
    ..effects of MNA and its parent molecule, nicotinamide, in the contact hypersensitivity reaction to oxazolone in CBA/J inbred mice...
  23. ncbi Oxazolone versus macrocycle structures for Leu-enkephalin b2-b4: insights from infrared multiple-photon dissociation spectroscopy and gas-phase hydrogen/deuterium exchange
    Xian Chen
    Department of Chemistry, University of Florida, Gainesville, Florida 32611 7200, USA
    J Am Soc Mass Spectrom 21:1313-21. 2010
    ..Infrared spectroscopy reveals that b(2) exclusively adopts oxazolone structures, protonated at the N-terminus and at the oxazolone ring N, based on the presence and absence of ..
  24. ncbi Opposite effects of substance P and calcitonin gene-related peptide in oxazolone colitis
    Matthias A Engel
    Institute of Physiology and Pathophysiology, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Dig Liver Dis 44:24-9. 2012
    ..SP levels increase whilst CGRP levels decrease in colon specimens from patients with inflammatory bowel disease; thus suggesting the pro- and anti-inflammatory roles, respectively, of these neuropeptides...
  25. ncbi A DNA oligomer containing 2,2,4-triamino-5(2H)-oxazolone is incised by human NEIL1 and NTH1
    Katsuhito Kino
    Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314 1 Shido, Sanuki, Kagawa 769 2193, Japan
    Mutat Res 734:73-7. 2012
    The nucleobase derivative, 2,2,4-triamino-5(2H)-oxazolone (Oz), is an oxidation product of guanine or of 8-oxo-7,8-dihydroguanine that causes G-to-C transversions in DNA...
  26. pmc Local and systemic effects of co-stimulatory blockade using cytotoxic T lymphocyte antigen-4-immunoglobulin in dinitrofluorobenzene- and oxazolone-induced contact hypersensitivity in mice
    A D Christensen
    Experimental Immunology Group, Department of Immunopharmacology, Novo Nordisk A S, Måløv, Denmark
    Clin Exp Immunol 171:220-30. 2013
    ..We observed a dose-dependent suppression of the ear swelling in both dinitrofluorobenzene (DNFB)- and oxazolone-induced CHS...
  27. pmc STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines
    Michael J Rosen
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 190:1849-58. 2013
    ..In this study, we investigated the role of STAT6 in oxazolone colitis, a murine model of UC, by inducing colitis in STAT6-deficient (STAT6(-/-)) and wild type (WT) mice...
  28. ncbi Synthesis of novel azo compounds containing 5(4H)-oxazolone ring as potent tyrosinase inhibitors
    Hooshang Hamidian
    Department of Chemistry, Payame Noor University, PO Box 19395 3697, Tehran, Iran
    Bioorg Med Chem 21:2088-92. 2013
    Six new azo dyes containing of 5(4H)-oxazolone ring were prepared by diazotization of 4-aminohippuric acid and coupling with N,N-dimethylaniline, 1-naphthol and 2-naphthol and condensation with 4-fluoro benzaldehyde or 4-trifluoromethoxy ..
  29. pmc Quantitation of four guanine oxidation products from reaction of DNA with varying doses of peroxynitrite
    Hongbin Yu
    Biological Engineering Division, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 56 731A, Cambridge, Massachusetts 02139, USA
    Chem Res Toxicol 18:1849-57. 2005
    ..8-oxodG), 2,2-diamino-4[(2-deoxy-beta-d-erythro-pentafuranosyl)amino]-5(2H)-oxazolone (oxazolone), spiroiminodihydantoin, and N1-(beta-d-erythro-pentofuranosyl)-5-guanidinohydantoin (..
  30. ncbi In vitro differentiation of skin sensitizers by cell signaling pathways
    L M Koeper
    Bayer HealthCare AG, Toxicology, Aprather Weg, D 42096, Wuppertal, Germany
    Toxicology 242:144-52. 2007
    ..skin models (epidermal model EST-1000 and full-thickness model AST-2000) were exposed to sensitizing (oxazolone and DNFB) or irritant compounds (SDS and TritonX-100)...
  31. ncbi Oral administration of glucosylceramide ameliorates inflammatory dry-skin condition in chronic oxazolone-induced irritant contact dermatitis in the mouse ear
    Mijung Yeom
    Acupuncture and Meridian Science Research Center, Kyung Hee University, Hoegi dong, Dongdaemoon gu, Seoul 130 702, Republic of Korea
    J Dermatol Sci 67:101-10. 2012
    ..A major characteristic of chronic ICD is an inflammatory dry-skin condition with associated itching. Although glucosylceramide (GlcCer) is known to improve the skin barrier function, its mechanism of action is unknown...
  32. pmc Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rγ(null) mice engrafted with human peripheral blood mononuclear cells
    Thomas Nolte
    Institute of Molecular Animal Breeding and Biotechnology, and Laboratory for Functional Genome Analysis, Gene Center, LMU Munich, 81377 Munich, Germany
    Dis Model Mech 6:125-34. 2013
    ..Here, we examine the induction of oxazolone-mediated features of atopic dermatitis (AD) in NOD-scid IL2Rγ(null) mice engrafted with human peripheral blood ..
  33. ncbi Biomechanical changes in oxazolone-induced colitis in BALB/C mice
    Jian Yang
    Mech Sense, Aalborg Hospital Science and Innovation Centre AHSIC, Aalborg Hospital, Sdr Skovvej 15, DK 9000 Aalborg, Denmark
    J Biomech 42:811-7. 2009
    ..The aim was to study acute morphological and biomechanical properties of the distal colon in oxazolone-induced UC in BALB/C mice. Six normal male BALB/C mice and 10 oxazolone-induced UC mice were studied...
  34. pmc Evidence of diketopiperazine and oxazolone structures for HA b2+ ion
    Brittany R Perkins
    Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, USA
    J Am Chem Soc 131:17528-9. 2009
    Peptide fragmentation can lead to an oxazolone or diketopiperazine b(2)(+) ion structure...
  35. ncbi Administration of Ag85B showed therapeutic effects to Th2-type cytokine-mediated acute phase atopic dermatitis by inducing regulatory T cells
    Hitoshi Mori
    Department of Dermatology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Arch Dermatol Res 301:151-7. 2009
    ..the effect of plasmid DNA encoding Ag85B derived from Mycobacterium kansasii on AD skin lesions induced by oxazolone (OX) application...
  36. ncbi Fragmentation of deprotonated N-benzoylpeptides: formation of deprotonated oxazolones
    Alex G Harrison
    Department of Chemistry, University of Toronto, Toronto, Ontario, Canada
    J Am Soc Mass Spectrom 15:446-56. 2004
    ..This observation is rationalized in terms of formation of deprotonated 2-phenyl-5-oxazolone. Various pathways to the deprotonated oxazolone have been elucidated through MS3 experiments...
  37. pmc Mast cell-derived tumor necrosis factor can promote nerve fiber elongation in the skin during contact hypersensitivity in mice
    Maki Kakurai
    Department of Pathology, L 235, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA 94305 5324, USA
    Am J Pathol 169:1713-21. 2006
    ..We found that contact hypersensitivity reactions to oxazolone in mice were associated with significant increases in the length of nerves in the epidermis and dermis...
  38. ncbi The effects of ginsenoside Re and its metabolite, ginsenoside Rh1, on 12-O-tetradecanoylphorbol 13-acetate- and oxazolone-induced mouse dermatitis models
    Yong Wook Shin
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Planta Med 72:376-8. 2006
    ..and its metabolite, ginsenoside Rh1, were investigated in 12-O-tetradecanoylphorbol 13-acetate (TPA)- and oxazolone-induced mouse ear dermatitis models...
  39. ncbi Increased and prolonged inflammation and angiogenesis in delayed-type hypersensitivity reactions elicited in the skin of thrombospondin-2--deficient mice
    Bernhard Lange-Asschenfeldt
    Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Blood 99:538-45. 2002
    ..were elicited in the ear skin of wild-type and TSP-2-deficient mice by topical sensitization and challenge with oxazolone. Cutaneous TSP-2 expression was up-regulated in the inflamed skin of wild-type mice, predominantly in dermal ..
  40. ncbi The traditional herbal medicine saireito exerts its inhibitory effect on murine oxazolone-induced colitis via the induction of Th1-polarized immune responses in the mucosal immune system of the colon
    Tetsuo Watanabe
    Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan
    Int Arch Allergy Immunol 151:98-106. 2010
    ..We analyzed the immunological characteristics of an oxazolone (OXZ)-induced colitis (OC) model and examined the effects of sareito on this model.
  41. ncbi Abrogation of high-affinity IgE receptor-mediated mast cell activation at the effector phase prevents contact hypersensitivity to oxazolone
    Maiko Kobayashi
    Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Department of Dermatology, Nihon University Graduate School of Medical Science, 30 1 Oyaguchikami cho Itabashi ku, Tokyo, Japan
    J Invest Dermatol 130:725-31. 2010
    ..that optimal MC activation through the FcepsilonRI beta-chain ITAM has essential roles in the onset of CHS to oxazolone (Oxa), a well-characterized chemical allergen...
  42. ncbi Nanoparticles enhance therapeutic efficiency by selectively increased local drug dose in experimental colitis in rats
    Alf Lamprecht
    Laboratory of Biopharmaceutics and Pharmaceutical Engineering, University of Franche Comte, Besancon, France
    J Pharmacol Exp Ther 315:196-202. 2005
    ..treatment by free drug was not different from colitis control in both 2,4,6-trinitrobenzenesulfonic acid and oxazolone colitis model...
  43. ncbi Topically applied diterpenoids from Egletes viscosa (Asteraceae) attenuate the dermal inflammation in mouse ear induced by tetradecanoylphorbol 13-acetate- and oxazolone
    Iana Bantim Felício Calou
    Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil
    Biol Pharm Bull 31:1511-6. 2008
    ..effectively inhibited the delayed-type hypersensitivity reaction induced by repeated topical application of 1% oxazolone (OXA, 20 microl/ear), as evidenced by significant decreases in ear thickness and interferon-gamma (INF-gamma) ..
  44. pmc Analysis of immunoglobulin (Ig) isotype diversity and IgM/D memory in the response to phenyl-oxazolone
    H White
    Department of Molecular Immunology, Institute of Child Health, London WC1N 1EH, United Kingdom
    J Exp Med 191:2209-20. 2000
    ..method, we have carried out a survey of the diversification of the isotype in a splenic response to phenyl-oxazolone (phOx) on a chicken serum albumin carrier...
  45. pmc Reduced recruitment of inflammatory cells in a contact hypersensitivity response in P-selectin-deficient mice
    M Subramaniam
    Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 181:2277-82. 1995
    The inflammatory response at sites of contact hypersensitivity induced by oxazolone was examined in the ears of P-selectin-deficient and wild-type mice...
  46. ncbi The effects of olopatadine hydrochloride on the number of scratching induced by repeated application of oxazolone in mice
    Tadafumi Tamura
    Pharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, Nagaizumi cho, Sunto gun, Shizuoka, Japan
    Eur J Pharmacol 524:149-54. 2005
    ..investigated the possible efficacy of olopatadine on the number of scratching induced by repeated application of oxazolone in BALB/c mice...
  47. ncbi Inhibition of delayed-type contact hypersensitivity in mice deficient in both E-selectin and P-selectin
    N D Staite
    Pharmacia and Upjohn Inc, Kalamazoo, MI 49001, USA
    Blood 88:2973-9. 1996
    ..b>Oxazolone-induced increases in ear thickness and ear weight were equivalent in wild-type mice and in P-selectin and E-..
  48. pmc Quantitative analysis of the oxidative DNA lesion, 2,2-diamino-4-(2-deoxy-beta-D-erythro-pentofuranosyl)amino]-5(2H)-oxazolone (oxazolone), in vitro and in vivo by isotope dilution-capillary HPLC-ESI-MS/MS
    Brock Matter
    Department of Medicinal Chemistry, University of Minnesota Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Nucleic Acids Res 34:5449-60. 2006
    A major DNA oxidation product, 2,2-diamino-4-[(2-deoxy-beta-D-erythro-pentofuranosyl)amino]-5(2H)-oxazolone (oxazolone), can be generated either directly by oxidation of dG or as a secondary oxidation product with an intermediate of 8-..
  49. ncbi Oxazolone-induced colitis in BALB/C mice: a new method to evaluate the efficacy of therapeutic agents for ulcerative colitis
    Ryotaro Kojima
    Research Laboratories, Nisshin Kyorin Pharmaceutical Co, Ltd, Iruma gun, Saitama, Japan
    J Pharmacol Sci 96:307-13. 2004
    ..In recent years, the murine oxazolone (OXA)-induced colitis model came to be accepted as a Th-2 type model, but it has yet to be used in any ..
  50. ncbi Effects of olopatadine hydrochloride, an antihistamine drug, on skin inflammation induced by repeated topical application of oxazolone in mice
    T Tamura
    Pharmaceutical Research Center, Kyowa Hakko Kogyo Co Ltd, 1188 Shimotogari, Nagaizumi cho, Sunto gun, Shizuoka 411 8731, Japan
    Br J Dermatol 151:1133-42. 2004
    ..Olopatadine hydrochloride (olopatadine) is one of the second-generation antihistamines, which is prescribed for allergic disorders such as rhinitis, urticaria and eczema dermatitis...
  51. ncbi Oxazolone-induced murine model of ulcerative colitis
    Xuan Wang
    Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China
    Chin J Dig Dis 5:165-8. 2004
    ..The aim of the present study was to set up an oxazolone-induced murine colitis model and use it to research the pathogenesis of inflammatory bowel disease.
  52. ncbi L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity
    Yuka Shimada
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Immunol 170:4325-34. 2003
    ....
  53. ncbi Interleukin 5 plays an essential role in elicitation of contact sensitivity through dual effects on eosinophils and B-1 cells
    Atsuko Itakura
    Division of Immunology, Department of Immunology and Microbiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Int Arch Allergy Immunol 140:8-16. 2006
    ..In this study, we investigated the role of interleukin (IL)-5, which has broad effects on both eosinophils and B-1 cells, in elicitation of CS...
  54. ncbi Inhibitory effect of ginsenoside Rg5 and its metabolite ginsenoside Rh3 in an oxazolone-induced mouse chronic dermatitis model
    Yong Wook Shin
    College of Pharmacy, Kyung Hee University, 1, Hoegi, Dongdaemun ku, Seoul 130 701, Korea
    Arch Pharm Res 29:685-90. 2006
    ..Ginsenosides Rg5 and Rh3 suppressed swelling of oxazolone-induced mouse ear contact dermatitis...
  55. ncbi Peroxynitrite production, DNA breakage, and poly(ADP-ribose) polymerase activation in a mouse model of oxazolone-induced contact hypersensitivity
    E Szabo
    Inotek Corporation, Beverly, Massachusetts, USA
    J Invest Dermatol 117:74-80. 2001
    ..detected nitrotyrosine, DNA breakage, and poly(ADP-ribose) polymerase activation in the epidermis of mice in an oxazolone-induced contact hypersensitivity model...
  56. ncbi Absence of CCR4 exacerbates skin inflammation in an oxazolone-induced contact hypersensitivity model
    Sari Lehtimäki
    Unit of Excellence for Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland
    J Invest Dermatol 130:2743-51. 2010
    ..We studied the effects of CCR4 deficiency in the murine model of oxazolone-induced contact hypersensitivity in CCR4-/- and wild-type (WT) mice...
  57. pmc Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators
    Yutaka Hatano
    Dermatology Service, Veterans Affairs Medical Center, University of California, San Francisco, CA, USA
    J Allergy Clin Immunol 125:160-9.e1-5. 2010
    ..Additionally, some of these activators exhibit potent antihyperplastic and anti-inflammatory activity in irritant contact dermatitis and acute allergic contact dermatitis murine models...
  58. ncbi Oxazolone-induced enterocolitis in zebrafish depends on the composition of the intestinal microbiota
    Sylvia Brugman
    Laboratory of Pediatrics, Pediatric Gastroenterology, Erasmus Medical Center, Rotterdam, The Netherlands
    Gastroenterology 137:1757-67.e1. 2009
    ..Interactions between host cells and bacteria are complicated, making it a challenge to assess their relative contribution to intestinal pathology. We developed a zebrafish model of enterocolitis to study these interactions...
  59. pmc NMR, mass spectrometry and chemical evidence reveal a different chemical structure for methanobactin that contains oxazolone rings
    Lee A Behling
    Chemistry Department, University of Wisconsin Eau Claire, Eau Claire, Wisconsin 54702, USA
    J Am Chem Soc 130:12604-5. 2008
    ..Our data also indicate that oxazolone rings instead of hydroxyimidazolate rings form the core of the two chromophoric residues...
  60. pmc Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis
    Yutaka Hatano
    Dermatology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 129:1824-35. 2009
    ..of the polyhydroxyl acid, lactobionic acid, during the repeated-challenge phase inhibited the development of oxazolone-induced atopic dermatitis (AD)...
  61. ncbi Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models
    Mary Y Sheu
    Department of Medicine, University of California San Francisco School of Medicine, San Francisco, California, USA
    J Invest Dermatol 118:94-101. 2002
    ....
  62. ncbi Allergic rhinitis induced by intranasal sensitization and challenge with trimellitic anhydride but not with dinitrochlorobenzene or oxazolone in A/J mice
    Aimen K Farraj
    Department of Pharmacology and Toxicology, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 79:315-25. 2004
    ..known chemical respiratory allergen TMA, but not the nonrespiratory sensitizers dinitrochlorobenzene (DNCB) and oxazolone (OXA), will induce characteristic features of LMW chemical-induced allergic airway disease in the nasal and ..
  63. ncbi Immunological competence in Snell-Bagg pituitary dwarf mice: response to the contact-sensitizing agent oxazolone
    G B Schneider
    Am J Anat 145:371-93. 1976
    ..Therefore, this investigation was undertaken to study the response of dwarf mice to the hapten, oxazolone, which produces one type of T-cell-dependent response, delayed hypersensitivity, and to compare this response to ..
  64. ncbi Restriction-PCR fingerprinting of the immunoglobulin VH repertoire: direct detection of an immune response and global analysis of B cell clonality
    H N White
    University College London, Department of Oncology and Imperial Cancer Research Fund, Tumour Immunology Unit, GB
    Eur J Immunol 28:3268-79. 1998
    ..Res-PCR is a rapid and revealing method which will allow analysis of the complexity and sequence composition of the B cell immunoglobulin repertoire and so perhaps better define the B cell memory compartment and immune responses in vivo...
  65. ncbi Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model
    Agnes Bánvölgyi
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7624 Pecs, Szigeti u 12, Hungary
    J Neuroimmunol 169:86-96. 2005
    ..b>Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h...
  66. ncbi Cellular dynamics in the draining lymph nodes during sensitization and elicitation phases of contact hypersensitivity
    Jeppe Madura Larsen
    Section of Experimental Immunology, Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, DK 2200 Copenhagen, Denmark
    Contact Dermatitis 57:300-8. 2007
    ....
  67. ncbi Expression of chemokine receptor CCR4 and its ligands (CCL17 and CCL22) in murine contact hypersensitivity
    Mayumi Kusumoto
    Department of Environmental Medicine, Kagoshima University School of Medicine, and Department of Medicine, Kagoshima Seikyo Hospital, Japan
    J Interferon Cytokine Res 27:901-10. 2007
    ..study, we investigated the expression of CCR4, CCL17, and CCL22 in a mouse model of contact hypersensitivity to oxazolone. Contact sensitization to oxazolone increased the proportions of memory CD4+ T cells in the draining lymph nodes,..
  68. ncbi A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice
    Xun Sun
    Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Gastroenterology 134:447-58. 2008
    ..In this study, we investigated the role of CD30L in oxazolone (OXA)- and trinitrobenzene sulfonic acid (TNBS)-induced colitis in CD30L knockout (KO) mice.
  69. ncbi CD1d and CD1d-restricted iNKT-cells play a pivotal role in contact hypersensitivity
    Edward E S Nieuwenhuis
    Gastrointestinal Division, Brigham and Women s Hospital, Boston, MA, USA
    Exp Dermatol 14:250-8. 2005
    ..Thus, pharmacologic antagonists of CD1d can be used as effective inhibitors of CHS, a prototype for a variety of delayed-type tissue hypersensitivity responses...
  70. ncbi Regulatory cells induced by feeding TNP-haptenated colonic protein cross-protect mice from colitis induced by an unrelated hapten
    Monica Boirivant
    Department of Infectious, Parasitic and Immune Mediated Diseases Istituto Superiore di Sanità, Roma, Italy
    Inflamm Bowel Dis 11:48-55. 2005
    ..we reasoned that TNP-HCP feeding would also "cross-protect" mice from colitis induced by a different hapten, oxazolone. Indeed, we found that feeding TNP-HCP protected mice from the development of oxazolone-colitis, albeit to a ..
  71. ncbi Vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK 222584 inhibits both the induction and elicitation phases of contact hypersensitivity
    Aisaku Yamamoto
    Department of Dermatology, Showa University School of Medicine, Shinagawa ku, Tokyo, Japan
    J Dermatol 34:419-29. 2007
    ..These findings and previous demonstrations suggest that both VEGF R-1 and VEGF R-2 are needed during the induction phase, and that VEGFR-2 has a pivotal role in the elicitation phase of the CHS reaction...
  72. pmc Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1
    Nicholas W Gale
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    Mol Cell Biol 27:595-604. 2007
    ..of cutaneous CD11c(+) dendritic cells to draining lymph nodes via afferent lymphatics and normal resolution of oxazolone-induced skin inflammation...
  73. ncbi Involvement of the cannabinoid CB2 receptor and its endogenous ligand 2-arachidonoylglycerol in oxazolone-induced contact dermatitis in mice
    Saori Oka
    Faculty of Pharmaceutical Sciences, Teikyo University, Sagamihara, Kanagawa 199 0195, Japan
    J Immunol 177:8796-805. 2006
    ..We found that the level of 2-AG was markedly elevated in the ear following a challenge with oxazolone in sensitized mice...
  74. pmc Antigen-specific immunoglobulin E+ B cells are preferentially localized within germinal centres
    Kathleen A Kelly
    Department of Pathology and Laboratory Medicine, Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA
    Immunology 120:345-53. 2007
    ..Taken together, these data highlight the importance of GCs in the production of antigen-specific IgE antibody...
  75. ncbi Evaluation of an ex vivo murine local lymph node assay: multiple endpoint comparison
    Joseph R Piccotti
    Worldwide Safety Sciences, Pfizer Global Research and Development, Ann Arbor, MI 48105, USA
    J Appl Toxicol 26:333-40. 2006
    ..In the current study, BALB/c mice were treated with the contact sensitizers hexylcinnamic aldehyde (HCA) and oxazolone, and the nonsensitizer methyl salicylate...
  76. pmc Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis
    Philippe Azam
    Department of Medical Pharmacology and Toxicology, University of California, Davis, California 95616, USA
    J Invest Dermatol 127:1419-29. 2007
    ..accordance with its selective effect on T(EM) cells, PAP-1 did not impair sensitization, but potently suppressed oxazolone-induced inflammation by inhibiting the infiltration of CD8+ T cells and reducing the production of the ..
  77. ncbi Helminth infection enhances disease in a murine TH2 model of colitis
    Meaghan M Hunter
    Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 132:1320-30. 2007
    ..Here the ability of the rat tapeworm Hymenolepis diminuta to affect the course of oxazolone-induced colitis (a TH2 model) was assessed.
  78. ncbi Immune sensitization in the skin is enhanced by antigen-independent effects of IgE on mast cells
    Paul J Bryce
    Division of Immunology, Children s Hospital, Boston, MA 02115, USA
    Novartis Found Symp 271:15-24; discussion 24-38, 95-9. 2005
    ..wild-type skin after hapten exposure. We propose that levels of IgE normally present in mice favour immune sensitization via antigen-independent effects on mast cells...
  79. pmc Phase-dependent roles of E-selectin during chronic contact hypersensitivity responses
    Tomoyuki Fujita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Am J Pathol 170:1649-58. 2007
    ..Elicitation with oxazolone on the ears of P-selectin(-/-) mice 7 days after the sensitization induced a typical delayed-type ..
  80. ncbi Induction of regulatory T cells by leflunomide in a murine model of contact allergen sensitivity
    Benno Weigmann
    Clinical Research Unit Allergology, Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    J Invest Dermatol 126:1524-33. 2006
    ..allergic response induced in mice by epicutaneous application of the haptens dinitrofluorobenzene (DNFB) and oxazolone. The extent of ear swelling remained significantly reduced following repeated challenge with DNFB for up to 18 ..
  81. ncbi Toll-like receptor ligands reverse suppression of contact hypersensitivity reactions induced by epicutaneous immunization with protein antigen
    Włodzimierz Ptak
    Department of Immunology, Jagiellonian University College of Medicine, Krakow, Poland
    Int Arch Allergy Immunol 139:188-200. 2006
    ..The aim of this work was to test if EC application of Toll-like receptor (TLR) ligands together with protein antigen could reverse suppression of CS...
  82. ncbi T cells specific to hapten carrier but not to carrier alone assist in the production of anti-hapten and anti-carrier antibodies
    Takeyuki Shimizu
    Division of Structural Immunology, Research Institute for Biological Sciences, Tokyo University of Science, Yamazaki 2669, Noda, Chiba 278 0022, Japan
    Int Immunol 19:1157-64. 2007
    ..Therefore, we proposed a new model in which anti-hapten B cells are assisted by T cells specific to the haptenated carrier...
  83. ncbi Galanin expression in a murine model of allergic contact dermatitis
    Husameldin El-Nour
    Unit of Dermatology and Venereology, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Acta Derm Venereol 84:428-32. 2004
    ..Female BALB/c mice were sensitized with oxazolone and 6 days later challenged on the dorsal surface of ears, while control mice received vehicle...
  84. ncbi Impaired dendritic-cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein
    Sofia de Noronha
    Molecular Immunology Unit, Institute of Child Health, London WC1N 1EH, UK
    Blood 105:1590-7. 2005
    ..In vivo in both fluorescein isothiocyanate (FITC) and oxazolone contact hypersensitivity models, WASp-null Langerhans cell (LC) migration was compromised, as judged by exit ..
  85. ncbi The intensity of neutrophil infiltration controls the number of antigen-primed CD8 T cells recruited into cutaneous antigen challenge sites
    Tara Engeman
    Department of Immunology, The Cleveland Clinic Foundation, Ohio, USA
    J Leukoc Biol 76:941-9. 2004
    ..primed to one antigen (dinitrofluorobenzene) into the site when challenged with a completely different antigen (oxazolone)...
  86. ncbi Effect of protease-activated receptor-2 deficiency on allergic dermatitis in the mouse ear
    Junichi Kawagoe
    Tokyo Research Laboratories, Pharmaceutical Division, Kowa Company Ltd, Higashimurayama, Japan
    Jpn J Pharmacol 88:77-84. 2002
    ..Ear thickness, contact hypersensitivity (CH) induced by topical application of picryl chloride (PC) or oxazolone (Ox) after sensitization, and vascular permeability after ear passive cutaneous anaphylaxis (PCA) were compared ..
  87. ncbi Stimulatory effects of B7-related protein-1 on cellular and humoral immune responses in mice
    J Guo
    Amgen Inc, Thousand Oaks, CA 91320, USA
    J Immunol 166:5578-84. 2001
    ..B7RP-1-Fc stimulated contact hypersensitivity (CH) given near either the time of sensitization or challenge with oxazolone. When given near challenge time, B7RP-1-Fc stimulated CH more than a construct containing the extracellular ..
  88. pmc Influence of ageing on Langerhans cell migration in mice: identification of a putative deficiency of epidermal interleukin-1beta
    Marie Cumberbatch
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK
    Immunology 105:466-77. 2002
    ....
  89. ncbi Overlapping roles for granulocyte-macrophage colony-stimulating factor and interleukin-3 in eosinophil homeostasis and contact hypersensitivity
    S Gillessen
    Department of Adult Oncology, Dana Farber Cancer Institute Harvard Medical School, Boston, MA, USA
    Blood 97:922-8. 2001
    ..Together, these findings delineate overlapping roles for GM-CSF and IL-3 in hematopoiesis and immunity. (Blood. 2001;97:922-928)..
  90. ncbi Contribution of Langerhans cell-derived IL-18 to contact hypersensitivity
    Binghe Wang
    Department of Dermatology, Johns Hopkins University, Baltimore, MD 21287, USA
    J Immunol 168:3303-8. 2002
    ..Taken together, our studies demonstrate that LC-derived IL-18 significantly contributes to CHS initiation...
  91. ncbi Oxazolone and diclofenac-induced popliteal lymph node assay reactions are attenuated in mice orally pretreated with the respective compound: potential role for the induction of regulatory mechanisms following enteric administration
    Bradford W Gutting
    Yale University School of Medicine, Section of Rheumatology, New Haven, CT 06520, USA
    Toxicol Appl Pharmacol 189:120-33. 2003
    ..We hypothesized that the contact sensitizer oxazolone (OX) would cause a strong PLN reaction in naive mice and that the PLN reaction would be attenuated in mice ..
  92. ncbi Validity of methods to predict the respiratory sensitizing potential of chemicals: A study with a piperidinyl chlorotriazine derivative that caused an outbreak of occupational asthma
    Jeroen A J Vanoirbeek
    Pneumology Lung Toxicology, Katholieke Universiteit Leuven, Leuven, Belgium
    Toxicol Sci 76:338-46. 2003
    ..PCT in comparison to a known respiratory sensitizer (toluene diisocyanate [TDI]) and a known dermal sensitizer (oxazolone), using three different methods in order to evaluate the validity of current models of sensitization...
  93. ncbi Chemical activation of innate and specific immunity in contact dermatitis
    L Zhang
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    J Invest Dermatol 115:168-76. 2000
    ..of these properties to the molecular and cellular mechanism underlying allergic contact dermatitis, we evaluated oxazolone-induced changes in cell populations and cytokine production in the dermis of transgenic mice with impaired ..
  94. ncbi Generation and function of reactive oxygen species in dendritic cells during antigen presentation
    Hiroyuki Matsue
    Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 171:3010-8. 2003
    ..Allergic contact hypersensitivity responses in BALB/c mice to oxazolone, but not irritant contact hypersensitivity responses to croton oil, were suppressed significantly by ..
  95. ncbi Hapten-specific tolerance induced by acute, low-dose ultraviolet B radiation of skin requires mast cell degranulation
    P Alard
    Schepens Eye Research Institute, Department of Dermatology, Harvard Medical School, Boston, USA
    Eur J Immunol 31:1736-46. 2001
    ..We conclude that mast cells are required in UVR-induced tolerance and may be one of the major sources of IL-10 that mediates the tolerance induced by acute, low-dose UVR...
  96. ncbi N,N'-diacetyl-L-cystine (DiNAC), the disulphide dimer of N-acetylcysteine, inhibits atherosclerosis in WHHL rabbits: evidence for immunomodulatory agents as a new approach to prevent atherosclerosis
    M Wågberg
    AstraZeneca R and D Molndal, Molndal, Sweden
    J Pharmacol Exp Ther 299:76-82. 2001
    ..tested the dimer of N-acetylcysteine, DiNAC, which is a disulfide with immunomodulating properties and enhances oxazolone-induced contact sensitivity (CS) reactions in mice, for effects on atherosclerosis...
  97. ncbi The role of IL-4, IL-10, and TNF-alpha in the immune suppression induced by ultraviolet radiation
    J M Rivas
    Department of Immunology, University of Texas, M D Anderson Cancer Center Houston 77030
    J Leukoc Biol 56:769-75. 1994
    ..Because anti-IL-4 and anti-IL-10 did not block the activity of the UV Ts that regulate contact hypersensitivity, their effects appear to be mediated by a different mechanism...
  98. ncbi Inhibition of glycolipid biosynthesis by N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin protects against the inflammatory response in hapten-induced colitis
    Chong Shen
    Laboratory of Experimental Immunology, Catholic University of Leuven, Campus Gasthuisberg O and N, Herestraat 49, B 3000 Leuven, Belgium
    Int Immunopharmacol 4:939-51. 2004
    ..AMP-DNM) in two hapten-induced colitis models: trinitrobenzene sulphonic acid (TNBS)- and oxazolone (4-ethoxymethylene-2phenyl-2oxazoline-5-one; Oxa)-induced colitis...
  99. ncbi Focal topographic changes in inflammatory microcirculation associated with lymphocyte slowing and transmigration
    C A West
    Laboratory of Immunophysiology, Harvard Surgical Research Laboratories, The Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Heart Circ Physiol 281:H1742-50. 2001
    ..intravital videomicroscopy to examine the dermal microcirculation after application of the epicutaneous antigen oxazolone. Intravascular injection of fluorescein-labeled dextran demonstrated focal topographic changes in the ..
  100. ncbi Impaired contact hypersensitivity in macrophage migration inhibitory factor-deficient mice
    Tadamichi Shimizu
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Eur J Immunol 33:1478-87. 2003
    ..response, MIF-deficient (MIF KO) and wild-type (WT) mice were sensitized with trinitrochlorobenzene (TNCB) or oxazolone on their abdominal skin and challenged on the dorsum skin of one ear 5 days later...
  101. ncbi Neuronal repellent Slit2 inhibits dendritic cell migration and the development of immune responses
    Hongbing Guan
    Department of Dermatology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 171:6519-26. 2003
    ..These findings provide insights into a novel mechanism by which Slit2 functions as an anti-inflammatory factor for the initiation of immune responses...

Research Grants19

  1. Th2 Cytokines and Signaling in Pediatric Inflammatory Bowel Disease
    Michael J Rosen; Fiscal Year: 2013
    ..Our data show that in the Th2-driven murine oxazolone colitis, there is increased epithelial- and macrophage-derived IL- 33, and that STAT6-/- mice exhibit decreased ..
  2. Novel Cytokine Regulation of Gut Function and Inflammation
    Aiping Zhao; Fiscal Year: 2013
    ..susceptibility of mice to colonic inflammation;2) Assess the effects of exogenous IL-25 on the course of TNBS-or oxazolone-induced colitis;and 3) Investigate the role of IL-25 in modulating the innate immune response through TLR ..
  3. Oxazolone Cycloadducts as Heterocyclic Scaffolds for Decahydroquinoline Alkaloid
    Stephen Philip Fearnley; Fiscal Year: 2013
    ..core differs slightly in that it features an electron-deficient 2 substituted diene, a system as yet untried in oxazolone Diels-Alders...
  4. MOUSE MODEL OF EOSINOPHIL MEDIATED SKIN PATHOLOGY
    James Lee; Fiscal Year: 1999
    ..induced cutaneous type I hypersensitivity) induced inflammation as well as contact hypersensitivity reactions (Oxazolone exposure); (3) Characterization of the cell adhesion molecule (L-selectin, P-selectin, E-selectin, ICAM or VLA-4)..
  5. GENETIC FINGERPRINTS OF IRRITANT CONTACT DERMATITIS
    Paul Bergstresser; Fiscal Year: 2000
    ..the 5-20 fingerprint genes that are highly activated by each of three irritant chemicals (sodium lauryl sulfate, oxazolone, and dinitrofluorobenzene), in three mouse strains (Balb/c, CBA, and C57/BL6)...
  6. REGULATION OF COLITIS BY CYCLOOXYGENASE-2
    Keith Wilson; Fiscal Year: 2001
    ..placebo and determine the regulatory role of COX-2 in: 1. models of Th1 (TNBS) and Th2 (oxazolone) mediated colitis and 2. Colonic inflammation and injury due to H. hepaticus and C. rodentia...
  7. KINETIC PHENOTYPE OF B CELLS DURING IMMUNE RESPONSES
    Jefferson Foote; Fiscal Year: 2000
    ..chicken fatty acid binding protein (FABP) coupled through its single cys residue to the hapten 2-phenyl-5-oxazolone (Ox)...
  8. THE BEHAVIOR OF CELL SUSPENSIONS IN VITRO AND IN VIVO
    ROBERT ROSENSTEIN; Fiscal Year: 1980
    Various inbred strains of mice and rats will be immunized with antigens such as sheep erythrocytes or the haptens oxazolone, 2,4-dinitrophenyl and 2,4,6 tri-nitrophenyl by protocols that result in the generation of suppressor cells...
  9. ELECTRO-OPTICAL DYES AS PROBES OF HEART EXCITABILITY
    Martin Morad; Fiscal Year: 1980
    ..These fibers 50-100 micrometer in diameter can be stained with voltage-dependent dyes such as Merocyanine Oxazolone. In the absence of the surface membrane an optical signal can be monitored which occurs with contractile ..
  10. Sequence Distribution of Tabacco Carcinogen-DNA Adducts
    Natalia Tretyakova; Fiscal Year: 2007
    ..The proposed research is significant because of the widespread human exposure to tobacco products and because of their central role in the initiation of lung cancer in humans. ..
  11. Oral Tolerance Induced by Encapsulated Allergen
    DALE UMETSU; Fiscal Year: 2004
    ..These studies therefore, are likely to lead to better methods and therapies that will induce protective immunity and allergen-specific tolerance, which will potentially cure patients with asthma and allergic diseases. ..
  12. Heterogeneity among human CD4 T lymphocytes
    Dale T Umetsu; Fiscal Year: 2010
    ..We are proposing new paradigms for the pathogenesis of asthma, and these new paradigms should lead to an improved understanding of asthma and to important novel therapies for asthma and allergy. ..
  13. Mechanisms by which Influenza A Protects Against Asthma
    DALE UMETSU; Fiscal Year: 2008
    ..We will also learn more about regulatory mechanisms that affect airway inflammation, and how viral infections and the environment affect the development of asthma. ..
  14. Role of Th Cell Subsets in Allergic Lung Inflammation
    DALE UMETSU; Fiscal Year: 2007
    ..These studies will ascertain the precise role of NK T cells in the development of asthma, and greatly enhance our understanding of pathogenic and protective mechanisms in asthma. ..
  15. Probiotics regulate intestinal epithelial cell homeostasis
    Fang Yan; Fiscal Year: 2008
    ..Genes regulated by LGG in colon cells will be identified using DNA microarray. These findings will have significant relevance to further understanding the probiotic regulation of intestinal health. ..
  16. IMMUNE PROTECTION AGAINST MNU-INDUCTED DIGITAL DEFECTS
    MARY PRATER; Fiscal Year: 2006
    ..This research under the guidance of Drs. Steven Holladay and Eric Wong at Virginia Tech...
  17. SQUAMOUS EPITHELIAL CELL INVASION IN ORGAN CULTURE
    James Varani; Fiscal Year: 2001
    ..abstract_text> ..
  18. TOPICAL RETINOIDS FOR DIABETIC FOOT ULCERS
    James Varani; Fiscal Year: 2003
    ..abstract_text> ..
  19. Mechanisms of MMP-3 Action in Acute Lung Injury
    James Varani; Fiscal Year: 2005
    ..These studies will provide an overall understanding of the mechanism(s) by which MMP-3 contributes to acute lung injury. ..