alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid


Summary: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.

Top Publications

  1. ncbi The pituitary adenylate cyclase-activating polypeptide modulates glutamatergic calcium signalling: investigations on rat suprachiasmatic nucleus neurons
    M D Kopp
    , Frankfurt, Germany
    J Neurochem 79:161-71. 2001
  2. ncbi Resistance of human adult oligodendrocytes to AMPA/kainate receptor-mediated glutamate injury
    Karolina Wosik
    Neuroimmunology Unit, Montreal Neurological Institute, Montreal, Quebec, Canada
    Brain 127:2636-48. 2004
  3. ncbi Testosterone amplifies excitotoxic damage of cultured oligodendrocytes
    A Caruso
    Department of Human Physiology and Pharmacology, University of Rome, La Sapienza, Rome, Italy
    J Neurochem 88:1179-85. 2004
  4. ncbi Miniature synaptic events maintain dendritic spines via AMPA receptor activation
    R A McKinney
    Brain Research Institute, University of Zurich, Switzerland
    Nat Neurosci 2:44-9. 1999
  5. ncbi Enhanced visual activity in vivo forms nascent synapses in the developing retinotectal projection
    Carlos D Aizenman
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    J Neurophysiol 97:2949-57. 2007
  6. pmc Mechanism of the distance-dependent scaling of Schaffer collateral synapses in rat CA1 pyramidal neurons
    Mark A Smith
    Neuroscience Center, LSUHSC, 2020 Gravier Street, New Orleans, LA 70112, USA
    J Physiol 548:245-58. 2003
  7. pmc Distinct quantal features of AMPA and NMDA synaptic currents in hippocampal neurons: implication of glutamate spillover and receptor saturation
    Yuri V Pankratov
    Bogomoletz Institute of Physiology, Kiev, Ukraine
    Biophys J 85:3375-87. 2003
  8. ncbi Encoding and decoding of dendritic excitation during active states in pyramidal neurons
    Stephen R Williams
    Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    J Neurosci 25:5894-902. 2005
  9. ncbi Maturation of a central glutamatergic synapse
    G Wu
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 274:972-6. 1996
  10. pmc Excitatory mechanisms in the suprachiasmatic nucleus: the role of AMPA/KA glutamate receptors
    Stephan Michel
    Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90024 1759, USA
    J Neurophysiol 88:817-28. 2002

Detail Information

Publications232 found, 100 shown here

  1. ncbi The pituitary adenylate cyclase-activating polypeptide modulates glutamatergic calcium signalling: investigations on rat suprachiasmatic nucleus neurons
    M D Kopp
    , Frankfurt, Germany
    J Neurochem 79:161-71. 2001
    ..The observed PACAPergic effects provide a broad range of interactions that allow a fine-tuning of the endogenous clock by the integration of 'light' and 'darkness' information on the level of single SCN neurons...
  2. ncbi Resistance of human adult oligodendrocytes to AMPA/kainate receptor-mediated glutamate injury
    Karolina Wosik
    Neuroimmunology Unit, Montreal Neurological Institute, Montreal, Quebec, Canada
    Brain 127:2636-48. 2004
    ..The apparent lack of glutamate receptor expression on human OLs and their resistance to AMPA/kainate toxicity should be considered when postulating mechanisms of tissue injury in multiple sclerosis...
  3. ncbi Testosterone amplifies excitotoxic damage of cultured oligodendrocytes
    A Caruso
    Department of Human Physiology and Pharmacology, University of Rome, La Sapienza, Rome, Italy
    J Neurochem 88:1179-85. 2004
    ..We conclude that testosterone amplifies excitotoxic damage of oligodendrocytes acting at an early step of the death cascade triggered by AMPA/kainate receptors...
  4. ncbi Miniature synaptic events maintain dendritic spines via AMPA receptor activation
    R A McKinney
    Brain Research Institute, University of Zurich, Switzerland
    Nat Neurosci 2:44-9. 1999
    ..Synaptically released glutamate thus exerts a trophic effect on spines by acting at AMPA receptors. We conclude that AMPA receptor activation by spontaneous vesicular glutamate release is sufficient to maintain dendritic spines...
  5. ncbi Enhanced visual activity in vivo forms nascent synapses in the developing retinotectal projection
    Carlos D Aizenman
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    J Neurophysiol 97:2949-57. 2007
    ..This suggests that in vivo visual stimulation increases synapses that have a low Pr and that have properties consistent with immature synapses...
  6. pmc Mechanism of the distance-dependent scaling of Schaffer collateral synapses in rat CA1 pyramidal neurons
    Mark A Smith
    Neuroscience Center, LSUHSC, 2020 Gravier Street, New Orleans, LA 70112, USA
    J Physiol 548:245-58. 2003
    ..We conclude, therefore, that the main synaptic mechanism involved in the production of distance-dependent scaling of Schaffer collateral synapses is an elevated postsynaptic AMPA receptor density...
  7. pmc Distinct quantal features of AMPA and NMDA synaptic currents in hippocampal neurons: implication of glutamate spillover and receptor saturation
    Yuri V Pankratov
    Bogomoletz Institute of Physiology, Kiev, Ukraine
    Biophys J 85:3375-87. 2003
  8. ncbi Encoding and decoding of dendritic excitation during active states in pyramidal neurons
    Stephen R Williams
    Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    J Neurosci 25:5894-902. 2005
    ..During active states, therefore, distal excitatory synaptic inputs decisively control the excitatory synaptic output of layer 5 neocortical pyramidal neurons and so powerfully influence network activity in the neocortex...
  9. ncbi Maturation of a central glutamatergic synapse
    G Wu
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 274:972-6. 1996
    ..Newly formed synapses may be silent unless sufficient depolarization is provided by coincident activity that could activate postsynaptic CaMKII, resulting in the appearance of AMPA responses...
  10. pmc Excitatory mechanisms in the suprachiasmatic nucleus: the role of AMPA/KA glutamate receptors
    Stephan Michel
    Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90024 1759, USA
    J Neurophysiol 88:817-28. 2002
    ..Overall, our data suggest that glutamatergic synaptic transmission mediated by AMPA/KA GluRs play an important role throughout the SCN synaptic circuitry...
  11. ncbi Cloning, expression and pharmacological characterization of a human glutamate receptor: hGluR4
    E J Fletcher
    Allelix Biopharmaceuticals Inc, Mississauga, ON, Canada
    Receptors Channels 3:21-31. 1995
    ..This is the first report of the cloning of hGluR4 receptor and its stable expression in a human cell line...
  12. ncbi Correlation of the expression of kainate receptor subtypes to responses evoked in cultured cortical and spinal cord neurones
    Wei Min Dai
    Department of Physiology, University of Aarhus, Ole Worms Alle 160, DK 8000 Aarhus C, Denmark
    Brain Res 926:94-107. 2002
    ..The most likely expression patterns of functional KA receptors is GluR6/KA2 for cortical neurones and GluR5/KA2 for spinal cord neurones...
  13. ncbi Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neurons
    Sang Hyoung Lee
    The Picower Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neuron 43:221-36. 2004
    ..Thus, GluR2 is a key subunit that controls recycling and degradation of AMPA receptors after internalization...
  14. ncbi Rapid synaptic plasticity of glutamatergic synapses on dopamine neurons in the ventral tegmental area in response to acute amphetamine injection
    Lavina J Faleiro
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
    Neuropsychopharmacology 29:2115-25. 2004
    ..We conclude that amphetamine induces rapid changes in synaptic AMPAR/NMDAR ratios, suggesting that potentiation of glutamatergic synapses is a relatively early event in the series of neuroadaptations in response to drugs of abuse...
  15. ncbi Expression of functional kainate and AMPA receptors in developing lateral superior olive neurons of the rat
    Harald Vitten
    Animal Physiology Group, Department of Biology, University of Kaiserslautern, Germany
    J Neurobiol 59:272-88. 2004
    ..Electrical stimulation of ipsilateral input fibers in the presence of KAR antagonists (NS-102 and GAMS), modulators (WGA), or GYKI 52466 revealed the presence of synaptic KARs in LSO neurons...
  16. ncbi Excitatory amino acid receptor subtype agonists induce feeding in the nucleus accumbens shell in rats: opioid antagonist actions and interactions with mu-opioid agonists
    J A Echo
    Department of Psychology and Neuropsychology Doctoral Sub-Program, Queens College, City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA
    Brain Res 921:86-97. 2001
    ..These data indicate the presence of important interactions between excitatory amino acid receptors and mu-opioid receptors in the nucleus accumbens shell in mediating feeding responses in nondeprived, ad libitum-fed rats...
  17. ncbi Chronic stress attenuates GABAergic inhibition and alters gene expression of parvocellular neurons in rat hypothalamus
    J Martin Verkuyl
    Swammerdam Institute for Life Sciences, Neurobiology Section, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 20:1665-73. 2004
  18. ncbi Dimethyl sulfoxide suppresses NMDA- and AMPA-induced ion currents and calcium influx and protects against excitotoxic death in hippocampal neurons
    C Lu
    Laboratory of Neurosciences, Gerontology Research Center 4F01, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Exp Neurol 170:180-5. 2001
    ..Our data also identify a mechanism that might explain clinical effects of DMSO on both peripheral and CNS neurons and suggest a potential use for DMSO in the treatment of excitotoxic neurodegenerative conditions...
  19. ncbi Long-term depression at olfactory nerve synapses
    Hiroki Mutoh
    Laboratory for Neuronal Circuit Dynamics, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 25:4252-9. 2005
    ..LTD at the ON--> MC synapse is potentially relevant for the establishment, maintenance, and experience-dependent refinement of odor maps in the olfactory bulb...
  20. pmc D-aspartate and NMDA, but not L-aspartate, block AMPA receptors in rat hippocampal neurons
    Xiang Qun Gong
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Br J Pharmacol 145:449-59. 2005
    ..The prevalence of D-aspartate in the brain suggests a possible role of D-aspartate in modulating AMPAR-mediated fast excitatory synaptic transmission...
  21. ncbi Transient Ca2+-permeable AMPA receptors in postnatal rat primary auditory neurons
    Michel Eybalin
    INSERM U583, Institut des Neurosciences, Hopital St Eloi, 80, avenue Augustin Fliche, BP 74103, 34091 Montpellier Cedex 5, France
    Eur J Neurosci 20:2981-9. 2004
    ..The postsynaptic expression of GluR2 subunits may be continuously regulated by the presynaptic activity allowing for variations in the Ca2+ permeability and physiological properties of the receptor...
  22. ncbi Electrophysiological and neurochemical characterization of neurons of the medial preoptic area in Japanese quail (Coturnix japonica)
    Charlotte A Cornil
    Center for Cellular and Molecular Neurobiology, Research Group in Behavioral Neuroendocrinology, University of Liege, 17 Place Delcour Bat L1, B 4020 Liege, Belgium
    Brain Res 1029:224-40. 2004
  23. ncbi Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat
    Claudia Iserhot
    Johannes Mueller Institute of Physiology, Dept of Neurophysiology, Faculty of Medicine Charite, Humboldt University, Tucholskystr 2, 10117 Berlin, Germany
    Brain Res 1027:151-60. 2004
    ..The present data suggest that glutamate transporters and group I/II mGluRs regulate excitatory synaptic transmission in the mEC. Presynaptic mGluRs may limit excessive glutamate accumulation if uptake becomes compromised...
  24. ncbi Nitric oxide produced by non-motoneuron cells enhances rat embryonic motoneuron sensitivity to excitotoxins: comparison in mixed neuron/glia or purified cultures
    D Comoletti
    Laboratory of Receptor Pharmacology, Mario Negri Institute for Pharmacological Research, Via Eritrea, 62, 20157 Milan, Italy
    J Neurol Sci 192:61-9. 2001
  25. ncbi Dopamine release in the prefrontal cortex during stress is reduced by the local activation of glutamate receptors
    A Del Arco
    Department of Physiology, Faculty of Medicine, University Complutense, Madrid, Spain
    Brain Res Bull 56:125-30. 2001
    ..These results show that the local activation of prefrontal glutamatergic ionotropic receptors reduces the stress-induced dopamine release in the prefrontal cortex of the rat...
  26. ncbi Knocking out the glial glutamate transporter GLT-1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemia
    Martine Hamann
    Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK
    Eur J Neurosci 15:308-14. 2002
    ..These data are consistent with glutamate release being by reversal of neuronal transporters, and with uptake into glia being compromised by the ischaemia-evoked fall in the level of ATP needed to convert glutamate into glutamine...
  27. ncbi Ca(2+) influx through AMPA or kainate receptors alone is sufficient to initiate excitotoxicity in cultured oligodendrocytes
    Elena Alberdi
    Departamento de Neurociencias, Universidad del Pais Vasco, Leioa, Vizcaya, Spain
    Neurobiol Dis 9:234-43. 2002
  28. ncbi NMDA and AMPA/kainate glutamatergic agonists increase the extracellular concentrations of GABA in the prefrontal cortex of the freely moving rat: modulation by endogenous dopamine
    Alberto Del Arco
    Department of Physiology, Faculty of Medicine, University Complutense, Ciudad Universitaria s n, 28040 Madrid, Spain
    Brain Res Bull 57:623-30. 2002
  29. ncbi RNA synthesis-dependent potentiation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor-mediated toxicity by antihistamine terfenadine in cultured rat cerebellar neurons
    Ramon Diaz-Trelles
    Department of Biochemistry and Molecular Biology, University of Oviedo, Campus El Cristo, 33071 Oviedo, Spain
    Neurosci Lett 345:136-40. 2003
    ..Terfenadine reduced neuronal steady-state concentrations of [Ca2+](i) by approximately 75%. Our results suggest a role for histamine H1 receptors and intracellular calcium in the modulation of the excitotoxic response via AMPA receptors...
  30. ncbi Inhibition of glutamate-induced nitric oxide synthase activation by dopamine in cultured rat retinal neurons
    Tomofusa Yamauchi
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Neurosci Lett 347:155-8. 2003
    ..These results suggest that dopamine inhibits glutamate induced-NOS activation via D1 receptor, resulting in the protection of retinal neurons...
  31. ncbi Depressor responses to L-proline microinjected into the rat ventrolateral medulla are mediated by ionotropic excitatory amino acid receptors
    Yumi Takemoto
    Department of Neurophysiology, Division of Integrated Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Auton Neurosci 120:108-12. 2005
    ..The results indicate that the depressor response to L-proline in the CVLM includes mechanisms of ionotropic excitatory amino acid receptors...
  32. ncbi Mitochondrial apoptotic cell death and moderate superoxide generation upon selective activation of non-desensitizing AMPA receptors in hippocampal cultures
    A Cristina Rego
    Institute of Biochemistry, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    J Neurochem 86:792-804. 2003
    ..Taken together, these data make important contributions to the elucidation of the downstream pathways activated in AMPA receptor-mediated excitotoxicity in cultured rat hippocampal neurones...
  33. ncbi Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues
    Jon Valgeirsson
    Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, 2 Universitetsparken, DK 2100 Copenhagen, Denmark
    Bioorg Med Chem 11:4341-9. 2003
    ..Compounds 4a-h may be useful tools for the progressing pharmacophore mapping of the GluR5 agonist binding site...
  34. pmc Ethanol withdrawal hyper-responsiveness mediated by NMDA receptors in spinal cord motor neurons
    Hui Fang Li
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, U S A
    Br J Pharmacol 139:73-80. 2003
    ..Both tyrosine kinase and PKC, but not PKA, appear to be essential for EtOH withdrawal hyper-responsiveness mediated by postsynaptic NMDA receptors in spinal cord motor neurons...
  35. ncbi Chronic nicotine causes functional upregulation of ionotropic glutamate receptors mediating hippocampal noradrenaline and striatal dopamine release
    Francesca Risso
    Sezione di Farmacologia e Tossicologia, Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Viale Cembrano 4, Genoa 16148, Italy
    Neurochem Int 44:293-301. 2004
    ..Thus, chronic exposure to nicotine enhances the function of ionotropic glutamate receptors mediating noradrenaline release in the hippocampus and dopamine release in the striatum...
  36. ncbi Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders
    Paulo Roberto Louzada
    Departamento de Bioquimica Medica, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941 590, Brasil
    FASEB J 18:511-8. 2004
    ..GABAergic transmission may represent a promising target for the treatment of AD and other neurological disorders in which excitotoxicity plays a relevant role...
  37. ncbi Chronic NMDA receptor blockade from birth delays the maturation of NMDA currents, but does not affect AMPA/kainate currents
    Matthew T Colonnese
    Department of Biology, Department of Brain and Cognitive Science, and McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Neurophysiol 89:57-68. 2003
    ..Together the present data show that NR function is necessary for subsequent NR current regulation in vivo, but it is not essential for the developmental expression of normal AMPAR currents...
  38. ncbi Glutamatergic and serotonergic mechanisms in the dorsal facial area for common carotid artery blood flow control in the cat
    Chi Li Gong
    Department of Physiology, School of Medicine, China Medical College, Taichung, Taiwan, ROC
    Auton Neurosci 101:85-90. 2002
    ..Such response may be suppressed by 5-HT2 action...
  39. ncbi Carbon monoxide and metabotropic glutamate receptors in rat nucleus tractus solitarii: participation in cardiovascular effect
    Wan Chen Lo
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Road, Kaohsiung 813, Taiwan, ROC
    Eur J Pharmacol 454:39-45. 2002
    ..They also suggested that CO and excitatory amino acids may interact in the nucleus tractus solitarii of rats...
  40. ncbi Long-term potentiation of the AMPA and NMDA components of minimal postsynaptic currents in rat hippocampal field Ca1
    I T Bayazitov
    Institute of the Brain, Russian Academy of Medical Sciences, Moscow
    Neurosci Behav Physiol 32:533-40. 2002
  41. ncbi A proportional but slower NMDA potentiation follows AMPA potentiation in LTP
    Alanna J Watt
    Department of Biology and Volen National Center for Complex Systems, MS 08, 415 South Street, Brandeis University, Waltham, Massachusetts 02454, USA
    Nat Neurosci 7:518-24. 2004
    ..This may ensure that LTP does not alter the relative contributions of these two receptors to synaptic transmission and information processing...
  42. pmc Functional characteristics of non-NMDA-type ionotropic glutamate receptor channels in AII amacrine cells in rat retina
    Svein Harald Mørkve
    University of Bergen, Department of Anatomy and Cell Biology, Bergen, Norway
    J Physiol 542:147-65. 2002
    ..Thus, our results indicate expression of high-affinity, voltage-sensitive AMPA receptors with significant Ca2+ permeability and relatively large single-channel chord conductances in AII amacrine cells...
  43. ncbi AMPA, not NMDA, activates RhoA GTPases and subsequently phosphorylates moesin
    Su Jin Kim
    Department of Molecular Cell Biology, Sungkyunkwan Univresity School of Medicine, Suwon 440 746, Korea
    Exp Mol Med 36:98-102. 2004
    ..These results suggest that glutamate-induced phosphorylation of moesin may be mediated through the AMPA receptor/RhoA/Rho kinase pathway...
  44. ncbi AMPA receptor activation, but not the accumulation of endogenous extracellular glutamate, induces paralysis and motor neuron death in rat spinal cord in vivo
    Juan Carlos Corona
    Departamento de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico, D F, Mexico
    J Neurochem 89:988-97. 2004
  45. ncbi AMPA receptors on developing medial septum/diagonal band neurons are sensitive to early postnatal binge-like ethanol exposure
    Shu Huei Hsiao
    Department of Medical Pharmacology and Toxicology, Texas A and M University System Health Science Center, College of Medicine MS 1114, College Station, TX 77843 1114, USA
    Brain Res Dev Brain Res 142:89-99. 2003
    ..Repeating this inhibition during early postnatal binge-like intoxication can augment normal development of AMPAR function...
  46. ncbi BDNF-induced facilitation of afferent-evoked responses in lamina II neurons is reduced after neonatal spinal cord contusion injury
    Sandra M Garraway
    Department of Neurobiology and Behavior, 550 Life Sciences Bldg, State University of New York, Stony Brook, New York 11794 5230, USA
    J Neurophysiol 94:1798-804. 2005
    ..It seems more likely that diminished trkB expression and enhanced expression of truncated trkB receptors in the contused cord play a significant role in determining the reduced effect of BDNF under these conditions...
  47. ncbi Developmental changes in AMPA and kainate receptor-mediated quantal transmission at thalamocortical synapses in the barrel cortex
    Neil J Bannister
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 25:5259-71. 2005
    ..Thus, the developmental switch in transmission will dramatically alter information transfer at thalamocortical inputs to layer IV...
  48. ncbi TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity
    Nathalie Rouach
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
    Nat Neurosci 8:1525-33. 2005
  49. ncbi Association of c-fos mRNA expression and excitotoxicity in primary cultures of mouse neocortical and cerebellar neurons
    R Griffiths
    Neurochemistry Group, School of Biological and Medical Sciences, University of St Andrews, Fife, Scotland
    J Neurosci Res 48:533-42. 1997
  50. ncbi Regulation of the maturation of osteoblasts and osteoclastogenesis by glutamate
    Tzu Hung Lin
    Department of Pharmacology, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan
    Eur J Pharmacol 589:37-44. 2008
    ..Activation of both AMPA and NMDA receptors regulates the maturation of osteoblasts. NMDA but not AMPA affects receptor for activation of NF-kappaB ligand (RANKL)-induced osteoclastogenesis...
  51. ncbi Metabotropic glutamate receptors modulate the NMDA- and AMPA-induced gene expression in neocortical interneurons
    Kerstin Lindemeyer
    Institute of Experimental and Clinical Pharmacology and Toxicology, Albert Ludwigs University, Freiburg, Germany
    Cereb Cortex 16:1662-77. 2006
    ..Our results suggest that mGluRIs regulate the glutamate-induced gene expression in neocortical interneurons in a physiologically relevant manner...
  52. ncbi Presynaptic modulation by somatostatin in the neostriatum
    Violeta Gisselle Lopez-Huerta
    Departamento de Biofisica, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, PO Box 70 253, Mexico City, DF, 04510, Mexico
    Neurochem Res 33:1452-8. 2008
    ..In contrast, SST does not regulate inhibition coming from interneurons. Because, SST is released by a class of local interneuron, it is concluded that this neuron helps to regulate the selection of motor acts...
  53. pmc Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus
    Stephan Michel
    Department of Molecular Cell Biology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Neurosci 7:15. 2006
  54. ncbi Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors
    Isaac Shemer
    Department of Neuroscience, Retzius väg 8 A3 417, Karolinska Institutet, S 17177 Stockholm, Sweden
    Eur J Neurosci 23:2035-47. 2006
    ..We propose that soluble Abeta(ol)s trigger the diminution of synaptic plasticity in neocortical pyramidal cell networks during early stages of AD pathogenesis by preferentially targeting postsynaptic AMPA receptors...
  55. ncbi Contribution of spinal glutamatergic receptors to the antinociception caused by agmatine in mice
    Vinicius M Gadotti
    Departamento de Ciencias Fisiologicas, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Campus Universitario, Trindade, Florianopolis 88040 900, SC, Brazil
    Brain Res 1093:116-22. 2006
  56. pmc Ultrastructural localisation and differential agonist-induced regulation of AMPA and kainate receptors present at the presynaptic active zone and postsynaptic density
    Marco Feligioni
    Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, Bristol, UK
    J Neurochem 99:549-60. 2006
    ..NMDA treatment did not evoke changes in GluR3 localisation. Our results demonstrate that presynaptic and postsynaptic subunits are regulated in opposite directions by AMPA and NMDA stimulation...
  57. pmc Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission
    Emiliano M Rial Verde
    Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Neuron 52:461-74. 2006
    ..Our results demonstrate that Arc/Arg3.1 reduces the number of GluR2/3 receptors leading to a decrease in AMPAR-mediated synaptic currents, consistent with a role in the homeostatic regulation of synaptic strength...
  58. ncbi Isoflurane preconditioning decreases glutamate receptor overactivation-induced Purkinje neuronal injury in rat cerebellar slices
    Shuqiu Zheng
    Department of Anesthesiology, University of Virginia Health System, One Hospital Drive, P O Box 800710, Charlottesville, VA 22908 0710, USA
    Brain Res 1054:143-51. 2005
    ..Thus, isoflurane preconditioning reduced glutamate receptor overstimulation-induced neuronal injury/death. This neuroprotection may be PKC- and NOS-dependent...
  59. pmc Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental area
    Emanuela Argilli
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:9092-100. 2008
  60. ncbi Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors in prefrontal cortical pyramidal neurons by a novel allosteric potentiator
    P J Baumbarger
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Pharmacol Exp Ther 298:86-102. 2001
    ..The therapeutic implications of AMPA receptor potentiators are discussed...
  61. ncbi Glutamate receptor subtypes in human retinal horizontal cells
    Wen Shen
    Department of Physiology and Biophysics, University at Buffalo, Buffalo, NY 14214, USA
    Vis Neurosci 21:89-95. 2004
    ..The diversity of glutamate receptors in human horizontal cells suggests that synaptic input to these neurons may be multiplexed through both kainate and AMPA channels...
  62. ncbi Long-term potentiation of silent synapses in substantia gelatinosa neurons
    Sung Jun Jung
    Department of Physiology and Biophysics, Seoul National University College of Medicine, Seoul 110 799, South Korea
    Neuroreport 16:961-5. 2005
  63. pmc Post-pubertal disruption of medial prefrontal cortical dopamine-glutamate interactions in a developmental animal model of schizophrenia
    Kuei Yuan Tseng
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York, USA
    Biol Psychiatry 62:730-8. 2007
  64. ncbi Rap2-JNK removes synaptic AMPA receptors during depotentiation
    Yinghua Zhu
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Neuron 46:905-16. 2005
  65. ncbi Activation of p44/p42 MAP kinase in striatal neurons via kainate receptors and PI3 kinase
    G Fuller
    Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    Brain Res Mol Brain Res 89:126-32. 2001
    ..This provides evidence for a novel pathway linking striatal kainate receptors to ERK activation via PI3 kinase and MEK...
  66. ncbi Expression and regulation of Na pump isoforms in cultured cerebellar granule cells
    T M Soga
    Department of Biochemistry I, Yokohama City University School of Medicine, Yokohama, Japan
    Neuroreport 12:829-32. 2001
    ..The glutamate effects were mainly mediated by non-NMDA receptors. These results suggest that alpha1 isoform and alpha3/alpha2 isoforms are functionally important under basal conditions and after neuronal excitation, respectively...
  67. ncbi N-methyl-D-aspartate receptor-mediated mitochondrial Ca(2+) overload in acute excitotoxic motor neuron death: a mechanism distinct from chronic neurotoxicity after Ca(2+) influx
    M Urushitani
    Department of Neurology, Graduate School of Medicine, Kyoto University, Sakyoku, Kyoto, Japan
    J Neurosci Res 63:377-87. 2001
    ..These data indicate that acute excitotoxicity in spinal neurons is mediated by mitochondrial Ca(2+) overload and ROS generation through the activation of NMDA receptors. This mechanism is different from that of chronic GNT...
  68. ncbi The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid
    Rasmus P Clausen
    Department of Medicinal Chemistry, Danish University of Pharmaceutical Sciences, 2 Universitetsparken, DK 2100 Copenhagen, Denmark
    Eur J Pharmacol 499:35-44. 2004
  69. ncbi Ca2+ entry via AMPA-type glutamate receptors triggers Ca2+-induced Ca2+ release from ryanodine receptors in rat spiral ganglion neurons
    Rachel T Morton-Jones
    Department of Physiology, School of Medical Sciences, University of Auckland, Auckland, New Zealand
    Cell Calcium 43:356-66. 2008
    ..These data demonstrate functional coupling between somatic AMPA-type glutamate receptors and intracellular Ca(2+) stores via RyR-dependent CICR in primary auditory neurons...
  70. pmc Regulation of EPSPs by the synaptic activation of GABAB autoreceptors in rat hippocampus
    C H Davies
    Department of Pharmacology, University of Edinburgh, UK
    J Physiol 496:451-70. 1996
    ..regulation of AMPA and NMDA receptor-mediated EPSPs during various patterns of synaptic activation caused by the dynamic changes in GABA-mediated synaptic inhibition, which are orchestrated by GABAA autoreceptors in a frequency-dependent..
  71. ncbi Sulphur-containing excitatory amino acid-stimulated inositol phosphate formation in primary cultures of cerebellar granule cells is mediated predominantly by N-methyl-D-aspartate receptors
    A Gorman
    Division of Cell and Molecular Biology, School of Biological and Medical Sciences, University of Saint Andrews, Fife, Scotland, U K
    Neuroscience 59:299-308. 1994
    ..abstract truncated at 400 words)..
  72. pmc Histamine H3 receptor-mediated depression of synaptic transmission in the dentate gyrus of the rat in vitro
    R E Brown
    Department of Neurophysiology, Institute for Neurobiology, Magdeburg, Germany
    J Physiol 496:175-84. 1996
    ..The mechanism by which histamine depresses transmission is independent of that used by class III metabotropic glutamate receptors...
  73. ncbi BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage
    M J Leach
    Department of Pharmacology, Wellcome Research Laboratories, Beckenham, Kent, England, UK
    Stroke 24:1063-7. 1993
    ..Therefore, compounds that block the release of glutamate may be useful as cerebroprotective agents. The purpose of this study was to evaluate the cerebroprotective properties of a glutamate release inhibitor, BW619C89...
  74. ncbi Ultrastructural quantification of glutamate receptors at excitatory synapses in hippocampus of synapsin I+II double knock-out mice
    S Gylterud Owe
    Department of Anatomy and Centre for Molecular Biology and Neuroscience CMBN, University of Oslo, P O Box 1105 Blindern, N0317 Oslo, Norway
    Neuroscience 136:769-77. 2005
  75. ncbi Synaptic and nonsynaptic contributions to giant ipsps and ectopic spikes induced by 4-aminopyridine in the hippocampus in vitro
    R D Traub
    Department of Pharmacology, Division of Neuroscience, University of Birmingham School of Medicine, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Neurophysiol 85:1246-56. 2001
    ..We conclude that in 4-AP, axonal gap junctions could, at least in principle, account in part for both the large IPSPs, and for the antidromic activity in pyramidal neurons...
  76. ncbi Involvement of non-NMDA receptors in the rescue of weaver cerebellar granule neurons and sensitivity to ethanol of cerebellar AMPA receptors in oocytes
    B E Akinshola
    Department of Pharmacology, Howard University College of Medicine, Suite 3408 NPG Adams Bldg, 520 W Street N W, Washington, DC 20059, USA
    Brain Res Mol Brain Res 93:8-17. 2001
  77. ncbi Response properties of antral mechanosensitive afferent fibers and effects of ionotropic glutamate receptor antagonists
    J N Sengupta
    Division of Gastroenterology and Hepatology, MaccFund Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuroscience 125:711-23. 2004
  78. ncbi Antinociceptive properties of the hydroalcoholic extract, fractions and compounds obtained from the aerial parts of Baccharis illinita DC in mice
    Cristina Setim Freitas
    Department of Pharmacology, Sector of Biological Sciences, Federal University of Parana, Curitiba, PR, Brazil
    Basic Clin Pharmacol Toxicol 104:285-92. 2009
    ..Moreover, the antinociceptive action demonstrated in the present study supports the ethnomedical uses of this plant...
  79. ncbi Activation of glycine and glutamate receptors increases intracellular calcium in cells derived from the endocrine pancreas
    C D Weaver
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6600, USA
    Mol Pharmacol 54:639-46. 1998
  80. ncbi Pharmacological characterization of harmaline-induced tremor activity in mice
    Neil E Paterson
    Behavioral Pharmacology, PsychoGenics, Inc, Tarrytown, NY 10591, USA
    Eur J Pharmacol 616:73-80. 2009
    ..Further, these data provide additional evidence for the roles of ionotropic glutamate, GABA(A) and dopamine D(2)/D(3) receptors in the neurobiology of harmaline-induced tremor...
  81. ncbi Xenon attenuates excitatory synaptic transmission in the rodent prefrontal cortex and spinal cord dorsal horn
    Rainer Haseneder
    Department of Anesthesiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    Anesthesiology 111:1297-307. 2009
    ..In the current study, the authors examined the effects of xenon on synaptic transmission in the prefrontal cortex and the spinal cord dorsal horn (substantia gelatinosa)...
  82. pmc Species-dependent functional properties of non-NMDA receptors expressed in Xenopus laevis oocytes injected with mammalian and avian brain mRNA
    D Bowie
    Department of Pharmacology, School of Pharmacy, University of London
    Br J Pharmacol 111:803-10. 1994
    ..Our observations may reflect further heterogeneity of non-NMDA receptors in the central nervous system of different vertebrate species...
  83. ncbi Pharmacological properties of the potent epileptogenic amino acid dysiherbaine, a novel glutamate receptor agonist isolated from the marine sponge Dysidea herbacea
    R Sakai
    School of Fisheries Sciences, Kitasato University, Kesen gun Sanriku cho, Iwate, Japan
    J Pharmacol Exp Ther 296:650-8. 2001
    ..This novel excitatory amino acid may prove useful for evaluating the physiological and pathological roles of non-NMDA receptors, especially KA receptors, in the central nervous system...
  84. ncbi Blockade of AMPA receptors and volatile anesthetics: reduced anesthetic requirements in GluR2 null mutant mice for loss of the righting reflex and antinociception but not minimum alveolar concentration
    D T Joo
    Department of Anesthesia, University of Toronto, Ontario, Canada
    Anesthesiology 94:478-88. 2001
    ..To determine if interactions between anesthetics and AMPA receptors account for the increased sensitivity of (-/-) mice, the effects of volatile anesthetics that do not directly inhibit AMPA receptors were examined...
  85. ncbi Insights into the mechanisms of ifosfamide encephalopathy: drug metabolites have agonistic effects on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors and induce cellular acidification in mouse cortical neurons
    J Y Chatton
    Institute of Physiology and Laboratory of Neurological Research, Department of Neurology, University of Lausanne Medical School, Lausanne, Switzerland
    J Pharmacol Exp Ther 299:1161-8. 2001
    ..Both processes could provide the biochemical basis of the observed ifosfamide-associated encephalopathy...
  86. ncbi Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels
    Liping Huang
    Department of Pharmacology and Toxicology, University of Otago, PO Box 913, Dunedin, New Zealand
    J Pharm Pharmacol 60:1515-22. 2008
    ..These data suggest that components common to the two oils are worthy of focus to identify the actives underlying the neuronal depressant and anti-agitation activities reported...
  87. pmc Age-related functional changes of the glutamate receptor channels in rat Meynert neurones
    N Akaike
    Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    J Physiol 504:665-81. 1997
    ..The KA-induced IK(Ca), which developed with ageing, may thus function as one of the negative feedback systems, and thereby prevent excess cell excitation and neural damage, especially in adult rats...
  88. ncbi Effects of 5'-alkyl-benzothiadiazides on (R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor biophysics and synaptic responses
    Amy C Arai
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    Mol Pharmacol 62:566-77. 2002
    ..The large gain in potency conferred by alkyl substitution suggests that the 5' substituent is in intimate contact with the receptor, with the size of the substituent determining the way in which receptor kinetics is changed...
  89. ncbi Increase of the intracellular Ca2+ concentration mediated by transport of glutamate into rat hippocampal synaptosomes: characterization of the activated voltage sensitive Ca2+ channels
    J O Malva
    Center for Neurosciences of Coimbra, Department of Zoology, University of Coimbra, Portugal
    Neurochem Int 32:7-16. 1998
  90. ncbi Glutamatergic synaptic transmission participates in generating the hippocampal EEG
    L Stan Leung
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Hippocampus 14:510-25. 2004
    ..Excitatory glutamatergic synaptic currents, activated by afferents from the entorhinal cortex and CA3, are suggested to participate in hippocampal EEG activities...
  91. ncbi [Update on anti-NMDA receptor encephalitis]
    Takahiro Iizuka
    Department of Neurology, School of Medicine, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Brain Nerve 62:331-8. 2010
    ..In a recent case, a microscopic teratoma was detected on autopsy; therefore exploratory laparotomy may be considered in severe refractory cases...
  92. ncbi Chronic fluoxetine treatment increases expression of synaptic proteins in the hippocampus of the ovariectomized rat: role of BDNF signalling
    Olivia F O'Leary
    Neuroscience Centre, University of Helsinki, Finland
    Psychoneuroendocrinology 34:367-81. 2009
    ..Moreover, these effects were only observed in ovariectomized animals, thus suggesting that fluoxetine-induced increases in synaptic protein levels might only occur or become detectable when hippocampal synaptic connectivity is perturbed...
  93. ncbi Involvement of AMPA/kainate, NMDA, and mGlu5 receptors in the nucleus accumbens core in cue-induced reinstatement of cocaine seeking in rats
    Pia Bäckström
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Psychopharmacology (Berl) 192:571-80. 2007
    ..Nucleus accumbens glutamate transmission has been implicated in drug-seeking behavior, but the involvement of glutamate receptor subtypes in drug seeking maintained by drug-associated cues has not been fully investigated...
  94. ncbi Effects of 2-[N-(4-chlorophenyl)-N-methylamino]-4H-pyrido[3.2-e]-1,3-thiazin-4-one (YM928), an orally active alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist, in models of generalized epileptic seizure in mice and rats
    Hiroshi Yamashita
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba, Ibaraki, Japan
    J Pharmacol Exp Ther 308:127-33. 2004
    ..These results indicate that YM928 is a broad-spectrum anticonvulsant that would prove useful for the treatment of generalized seizure in human epileptic patients...
  95. ncbi Characterization of the anticonvulsant profile of isonicotinic acid benzylamide in various experimental seizure models in mice
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Neurosci Lett 421:87-90. 2007
    ..p. administration), deserves more attention as a potential antiepileptic drug for patients in status epilepticus...
  96. ncbi Desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors facilitates use-dependent inhibition by pentobarbital
    Michael F Jackson
    Department of Physiology, Medical Sciences Bldg, University of Toronto, 1 King s College Circle, Toronto, ON M5S 1A8, Canada
    Mol Pharmacol 64:395-406. 2003
    ..Our results suggest that PB does not act as an open channel blocker of AMPARs. Rather, the sensitivity, use dependence, and trapping of inhibition by PB are determined by AMPARs desensitization...
  97. pmc Signal transduction pathways involved in the acute potentiation of NMDA responses by 1S,3R-ACPD in rat hippocampal slices
    J Harvey
    Department of Pharmacology, Medical School, University of Birmingham
    Br J Pharmacol 109:1085-90. 1993
    ..It involves a Ca2+-sensitive process and is negatively regulated by protein kinase C...
  98. ncbi Blockade of glutamate receptors and barbiturate anesthesia: increased sensitivity to pentobarbital-induced anesthesia despite reduced inhibition of AMPA receptors in GluR2 null mutant mice
    D T Joo
    Department of Anaesthesia, University of Toronto, Ontario, Canada
    Anesthesiology 91:1329-41. 1999
  99. ncbi Large variability in synaptic N-methyl-D-aspartate receptor density on interneurons and a comparison with pyramidal-cell spines in the rat hippocampus
    G Nyiri
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, PO Box 37, H 1450, Hungary
    Neuroscience 119:347-63. 2003
    ..Consequently, fast glutamatergic activation of interneurons is expected to show cell type-specific time course and state-dependent dynamics...
  100. ncbi Modulatory effects of dextran sulfate and fucoidan on binding and channel properties of AMPA receptors isolated from rat brain
    Vishnu Suppiramaniam
    Department of Pharmacal Sciences, Harrison School of Pharmacy, Auburn University, Alabama 36849, USA
    Synapse 60:456-64. 2006
    ..These findings suggest that GAG components of proteoglycans can interact with and alter the binding affinity of AMPA receptors and modulate their functional properties...
  101. ncbi Excitatory and inhibitory modulation of taste responses in the hamster brainstem
    D V Smith
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore 21201 1509, USA
    Ann N Y Acad Sci 855:450-6. 1998
    ..Microinjection of SP into the NST enhances the responses of many NST cells to gustatory stimulation; NaCl-best neurons are preferentially excited by SP...

Research Grants68

  1. Mechanism of action of novel GluN2C NMDA receptor potentiators
    Alpa Khatri; Fiscal Year: 2013
    ..The data from this research could potentially be useful for developing new therapies for neurological disorders thought to be associated with aberrant NMDA receptor function such as, schizophrenia, autism, and psychosis. ..
  2. Molecular mechanisms of excessive alcohol consumption and relapse-like behavior
    REGINALD DEVON CANNADY; Fiscal Year: 2012
    ..Key findings from these studies will provide novel insight into AMPAR-related mechanisms in excessive alcohol drinking behavior and vulnerability to relapse. ..
  3. Control of AMPAR Trafficking by NMDAR-Mediated PKD1 Translocation
    EVA S LADOW; Fiscal Year: 2010
    ..This research aims to investigate how neurons regulate the sensitivity of their connections in response to neuronal activity. ..
  4. AMPA Receptor Trafficking in Schizophrenia
    JOHN CHARLES HAMMOND; Fiscal Year: 2012
    ..Accumulating evidence implicates glutamate receptors in schizophrenia. This project will examine glutamate receptor trafficking in this illness, ultimately leading to better diagnostic and treatment strategies. ..
  5. Regulation of D-serine Neuromodulation by PKCalpha and PICK1
    ASIF MUSTAFA; Fiscal Year: 2009
    ..All this will primarily be accomplished by a combination of radiolabeling experiments, the use of pharmacological agents, mass spectrometry analysis, site-directed mutagenesis and the DsdA-LDH assay. ..
    Roger Nicoll; Fiscal Year: 2001
    Roger Nicoll; Fiscal Year: 2006
    ..abstract_text> ..
  8. Synaptic signaling regulated by MALS family PDZ proteins
    Roger Nicoll; Fiscal Year: 2008
    ..Because MALS proteins regulate growth factor receptors and interact with NMDA type glutamate receptors at synapses, this work will be relevant to both tissue development and synaptic plasticity. ..
    AMY ARAI; Fiscal Year: 2004
    ..Determining which cellular factor stabilizes the low-affinity receptors will constitute the Fifth Aim of this application. ..
  10. Differential effects of TARPs on AMPA receptor subunits
    AMY ARAI; Fiscal Year: 2008
    ..unreadable] [unreadable]..
    Susan Carlton; Fiscal Year: 2004
    ..Peripheral SST receptors offer novel targets for nociceptor modulation and are likely targets for further development of non-opioid therapies to aid in reducing the pain and long-term deleterious changes that can accompany inflammation. ..
  12. Non-Peptide Somatostatin Agonist Analgesics
    Susan Carlton; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  13. Chemical Basis for Potassium Channel Modulation
    PAMELA ENGLAND; Fiscal Year: 2006
    ..To determine the site(s) in HERG that interact with other proteins, photoreactive amino acids capable of forming protein cross-links will be site-specifically incorporated into the HERG. ..
  14. Accumbens-pallidal GABA and morphine reinforcement
    Scott Hemby; Fiscal Year: 2005
    ..Changes in the expression levels of multiple genes will be assessed in terms of morphine reinforcement and direct pharmacological effects of the drug. ..
  15. Ethanol and Presynaptic GABA beta Receptor Function
    Jeffrey Weiner; Fiscal Year: 2007
  16. The Role of Glutamate and CCK in the PBN in Taste Reactivity
    Michael King; Fiscal Year: 2007
    ..Specifically, data collected during the proposed investigation will determine if glutamate and CCK in the PBN play a critical role in the assessment of ingested substances and subsequent behavioral responses. ..
  17. Mechanisms Underlying the Cognitive Function of Sleep
    Subimal Datta; Fiscal Year: 2009
  18. Hybrid Drugs: Novel Pharmacotherapy for ADHD
    FRANK TARAZI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
    Scott Hemby; Fiscal Year: 2008
    ..abstract_text> ..
  20. Neurodevelopmental Apoptosis
    Nuri Farber; Fiscal Year: 2008
    ..abstract_text> ..
  21. Stress-induced reinstatement of cocaine-seeking behavior
    Peter Kalivas; Fiscal Year: 2008
    ..abstract_text> ..
  22. Synaptic Correlates of Ethanol-Related Behaviors
    Jeffrey Weiner; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  23. Glucocorticoids and Apoptosis of Cerebellar Neural Progenitor Cells
    Nuri Farber; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  24. Entorhinal Transcriptome in Schizophrenia
    Scott Hemby; Fiscal Year: 2009
    ..To date, the treatment regimen, necropsy and tissue harvesting have been completed with both fresh frozen and paraffin-embedded EC available. ..
  25. Integrins and LTP consolidation
    Gary Lynch; Fiscal Year: 2008
    ..The results of these experiments are expected to provide a strong test of a specific hypothesis regarding how LTP, and therefore possibly memory, becomes consolidated. ..
  26. Effects of antipsychotic drugs on brain and behavior
    FRANK TARAZI; Fiscal Year: 2005 rats, and should evolve new principles for improved treatments for childhood-onset schizophrenia and other major pediatric psychiatric disorders. ..
    Gary Duncan; Fiscal Year: 2006
    ..unreadable] [unreadable]..
    Edward Jones; Fiscal Year: 2003
    ..Defective maturation may be a concomitant of or a basis for certain forms of seizures in young individuals. ..
    Peter Kalivas; Fiscal Year: 2003
    ..Furthermore, the anatomical and functional mapping of the motive circuit will provide a basis for interpreting future imaging studies in humans where attempts are made to correlate changes in spatially discrete nuclei. ..
  30. Effects/Ethanol/Specific sites/AMPA glutamate receptors
    BABATUNDE AKINSHOLA; Fiscal Year: 2004
    ..This grant will contribute significantly to the career establishment and development of the investigator by providing the time, salary support and supplies needed for education and training in alcohol research in a minority institution. ..
  31. Kinase Inhibitors against Neurodegeneration
    Gary Lynch; Fiscal Year: 2004
  32. Norepinephrine Transporters: Targets for ADHD
    FRANK TARAZI; Fiscal Year: 2004
    ..Expected findings should lead to novel compounds that can be developed as much needed innovative non-stimulant treatments for ADHD and other major neuropsychiatric disorders. ..
    David Linden; Fiscal Year: 2004
    ..In addition, they have potential clinical relevance for both cerebellar motor disorders and disorders of learning and memory generally. ..
    Jeffrey Weiner; Fiscal Year: 2002
  35. Ca permeable non-NMDAr: New spinal sensitization pathway
    Linda Sorkin; Fiscal Year: 2005
    ..We propose to investigate the effects of Ca-permeable non-NMDAr activation on ERK and CREB phosphorylation (using Western blots and immunohistochemistry), expression of c-fos and development of hyperalgesia. ..
    David Linden; Fiscal Year: 2002
    ..In addition, these investigations have potential clinical relevance not only for cerebellar motor disorders, but also for disorders of learning and memory generally. ..
    Carol Barnes; Fiscal Year: 2003
    ..NMDA receptor antagonists are expected to prevent experience-dependent place field changes in the young rats, and AMPA current enhancers are expected to ameliorate place field properties in the old rats. ..
  38. NABTT-Consortium Therapeutic Studies of CNS Malignancies
    Stuart Grossman; Fiscal Year: 2008
    ..abstract_text> ..
    Thomas Rosenquist; Fiscal Year: 2003
    ..abstract_text> ..
  40. Can beta-lactam antibiotics decrease morphine physical dependence?
    SCOTT RAWLS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  41. Annual Meeting of the American Pain Society
    Linda Sorkin; Fiscal Year: 2005
    ..Abstracts will be judged on scientific merit and published in The Journal of Pain. We believe that these awards will encourage meeting attendance by trainees. ..
  42. Integrin and LTP Consolidation
    Gary Lynch; Fiscal Year: 2003
    ..abstract_text> ..
  43. Dendritic Processing in the Olfactory Bulb
    Jason Christie; Fiscal Year: 2003
    ..The specific aims are: (1) to determine the function of autoexcitation in mitral cell processing and (2) to determine how dendritic compartmentalization effects mitral cell processing. ..
  44. Magnesium's Antihypertensive Effects in Preeclampsia
    CYNTHIA STANDLEY; Fiscal Year: 2003
    ..Data derived from these experiments will elucidate the anti-hypertensive effects of magnesium, its mode of action and the roles of NO and magnesium in preeclampsia and pregnancy-induced hypertension. ..
  45. Cardiovascular Response to Glutamate Nitric Oxide
    WILLIAM TALMAN; Fiscal Year: 2006
    ..e. on nNOS immunoreactive dendrites or neurons in NTS. ..
  46. Mechanisms of Synaptic Depression: Focus on Rap Signaling Pathways
    J Julius Zhu; Fiscal Year: 2010
    ..abstract_text> ..
    Robert Miller; Fiscal Year: 2004
    ..The purpose of this research is to formulate models which will work in synergy to guide and enhance our experimental efforts to decipher to mechanisms that are critical for function among third-order retinal neurons. ..
  48. Altered hypothalamic-pituitary-adrenal function in the Fragile X mouse
    JULIE LAUTERBORN; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  49. Genetic Mapping of Functional Neural Networks & Circuits
    Carol Barnes; Fiscal Year: 2006
    ..abstract_text> ..
  50. Use-dependent intrinsic plasticity in the cerebellum
    David J Linden; Fiscal Year: 2010
    ..Because these cellular and molecular processes are not only involved in memory storage, this work has implications for other brain diseases as well, including epilepsy and addiction. ..
  51. Myosin VI in Postsynaptic Function and Plasticity
    Emily Osterweil; Fiscal Year: 2004
    ..Myosin VI may be similarly critical for postsynaptic function and plasticity, deficits in which are seen in Down's syndrome, fragile X syndrome, and epilepsy. ..
  52. Estrogen and the Aging Blood Brain Barrier
    OAK CHI; Fiscal Year: 2002
    ..The information obtained from our study will be crucially important for the clinical application of estrogen therapy for stroke as well as understanding the pathophysiology of age related cerebrovascular changes. ..
  53. Genetic Dissection of Brain Reward Circuits
    LARRY ZWEIFEL; Fiscal Year: 2008
    ..abstract_text> ..
    SARAH BOTTJER; Fiscal Year: 2009
    ..abstract_text> ..
  55. Molecular Diagnosis Utilizing Cerebrospinal Fluid
    STEPHEN GINSBERG; Fiscal Year: 2003
    ..abstract_text> ..
  56. Alterations in chemoafferent integration induced by chronic intermittent hypoxia
    STEVEN MIFFLIN; Fiscal Year: 2008
    ..These factors mediate much of the pathology associated with sleep apnea including hypertension, increased risk of adverse cardiovascular events and insulin resistance. [unreadable] [unreadable] [unreadable]..
  57. International Congress of Neuroethology
    SARAH BOTTJER; Fiscal Year: 2004
    ..Thus, benefits to American scientists in general, and to young investigators in particular, will be the opportunity for exposure to cutting-edge research and techniques from around the World. ..
  58. Lesion Induced Synaptic Plasticity
    STEPHEN GINSBERG; Fiscal Year: 2004
  59. Cannabinoid Regulation of Basal Ganglia Glutamate and GABA
    SCOTT RAWLS; Fiscal Year: 2007
    ..Our outcomes will be a first step in determining whether blocking endocannabinoid inactivation offers any therapeutic advantage over direct activation of cannabinoid receptors with marijuana. [unreadable] [unreadable] [unreadable]..
  60. Cellular Plasticity Following Repeated Amphetamine
    Christopher Nelson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  61. Nitric Oxide Regulation of Platelet Granule Exocytosis
    CRAIG MORRELL; Fiscal Year: 2008
    ..Therefore, strategies to minimize granule exocytosis may prove valuable in the acute treatment of pro-thrombotic diseases. (End of Abstract) [unreadable] [unreadable]..
  62. Cerebellar Circuitry and Plasticity in an Electric Fish
    Victor Han; Fiscal Year: 2007
    ..The primary method will be whole-cell patch recordingin in vitro slices, combined with labelingof recorded elements for morphologicalidentification. ..
    STEVEN MIFFLIN; Fiscal Year: 2003
    STEVEN MIFFLIN; Fiscal Year: 2004
    ..Therefore, understanding the mechanisms that induce and underlie these adaptations will be of great importance in our understanding of cardiovascular regulation in hypertension. ..