creatinine

Summary

Top Publications

  1. pmc Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, 750 Washington St, Box 391, Boston, MA 02111, USA
    Am J Kidney Dis 51:395-406. 2008
  2. pmc A new equation to estimate glomerular filtration rate
    Andrew S Levey
    Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 150:604-12. 2009
  3. pmc Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
    Crit Care 8:R204-12. 2004
  4. ncbi Microalbuminuria in the US population: third National Health and Nutrition Examination Survey
    Camille A Jones
    Division of Genetics and Epidemiology, Joslin Diabetes Center, Boston, MA, 02215, USA
    Am J Kidney Dis 39:445-59. 2002
  5. pmc Neutrophil-independent mechanisms of caspase-1- and IL-18-mediated ischemic acute tubular necrosis in mice
    Vyacheslav Y Melnikov
    Department of Medicine, University of Colorado School of Medicine, 4200 East 9th Avenue, Denver, Colorado 80262, USA
    J Clin Invest 110:1083-91. 2002
  6. ncbi A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group
    A S Levey
    New England Medical Center, Boston, MA 02111, USA
    Ann Intern Med 130:461-70. 1999
  7. ncbi Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate
    Andrew S Levey
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 145:247-54. 2006
  8. doi Revised equations for estimated GFR from serum creatinine in Japan
    Seiichi Matsuo
    Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Kidney Dis 53:982-92. 2009
  9. ncbi Assessing kidney function--measured and estimated glomerular filtration rate
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    N Engl J Med 354:2473-83. 2006
  10. pmc Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis
    Kunihiro Matsushita
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument, Suite 2 630, Baltimore, MD 21287, USA
    Lancet 375:2073-81. 2010

Detail Information

Publications368 found, 100 shown here

  1. pmc Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, 750 Washington St, Box 391, Boston, MA 02111, USA
    Am J Kidney Dis 51:395-406. 2008
    Serum cystatin C was proposed as a potential replacement for serum creatinine in glomerular filtration rate (GFR) estimation...
  2. pmc A new equation to estimate glomerular filtration rate
    Andrew S Levey
    Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 150:604-12. 2009
    ..Equations to estimate glomerular filtration rate (GFR) are routinely used to assess kidney function. Current equations have limited precision and systematically underestimate measured GFR at higher values...
  3. pmc Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
    Crit Care 8:R204-12. 2004
    ..Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies...
  4. ncbi Microalbuminuria in the US population: third National Health and Nutrition Examination Survey
    Camille A Jones
    Division of Genetics and Epidemiology, Joslin Diabetes Center, Boston, MA, 02215, USA
    Am J Kidney Dis 39:445-59. 2002
    ..Untimed urinary albumin concentrations (UACs) and creatinine concentrations were evaluated in a nationally representative sample of 22,244 participants aged 6 years and ..
  5. pmc Neutrophil-independent mechanisms of caspase-1- and IL-18-mediated ischemic acute tubular necrosis in mice
    Vyacheslav Y Melnikov
    Department of Medicine, University of Colorado School of Medicine, 4200 East 9th Avenue, Denver, Colorado 80262, USA
    J Clin Invest 110:1083-91. 2002
    ..mice with ischemic ARF treated with OPH-001 had a marked (100%) reduction in blood urea nitrogen (BUN) and serum creatinine and a highly significant reduction in morphological acute tubular necrosis (ATN) score compared with vehicle-..
  6. ncbi A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group
    A S Levey
    New England Medical Center, Boston, MA 02111, USA
    Ann Intern Med 130:461-70. 1999
    Serum creatinine concentration is widely used as an index of renal function, but this concentration is affected by factors other than glomerular filtration rate (GFR).
  7. ncbi Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate
    Andrew S Levey
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 145:247-54. 2006
    ..rate (GFR) estimates facilitate detection of chronic kidney disease but require calibration of the serum creatinine assay to the laboratory that developed the equation...
  8. doi Revised equations for estimated GFR from serum creatinine in Japan
    Seiichi Matsuo
    Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Kidney Dis 53:982-92. 2009
    Estimation of glomerular filtration rate (GFR) is limited by differences in creatinine generation among ethnicities...
  9. ncbi Assessing kidney function--measured and estimated glomerular filtration rate
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    N Engl J Med 354:2473-83. 2006
  10. pmc Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis
    Kunihiro Matsushita
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument, Suite 2 630, Baltimore, MD 21287, USA
    Lancet 375:2073-81. 2010
    ..We undertook a meta-analysis to assess the independent and combined associations of eGFR and albuminuria with mortality...
  11. ncbi Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease
    Ying Chun Ma
    Division of Nephrology and Institute of Nephrology, The First Hospital, Peking University, No 8 Xishiku Street, Xicheng District, Beijing 100034, PR China
    J Am Soc Nephrol 17:2937-44. 2006
    ..original MDRD equations across CKD stages in a multicenter, cross-sectional study of GFR estimation from plasma creatinine, demographic data, and clinical characteristics...
  12. pmc Estimating glomerular filtration rate from serum creatinine and cystatin C
    Lesley A Inker
    Division of Nephrology, Tufts Medical Center, 800 Washington St, Box 391, Boston, MA 02111, USA
    N Engl J Med 367:20-9. 2012
    Estimates of glomerular filtration rate (GFR) that are based on serum creatinine are routinely used; however, they are imprecise, potentially leading to the overdiagnosis of chronic kidney disease...
  13. pmc New equations to estimate GFR in children with CKD
    George J Schwartz
    Department of Pediatrics, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Am Soc Nephrol 20:629-37. 2009
    ..GFR as measured by plasma disappearance of iohexol, likely a result of a change in methods used to measure creatinine. Here, we developed equations to estimate GFR using data from the baseline visits of 349 children (aged 1 to 16 ..
  14. pmc Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 113:192-200. 2005
    ..Urinary biomonitoring data typically are adjusted to a constant creatinine concentration to correct for variable dilutions among spot samples...
  15. ncbi Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    B M Brenner
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 345:861-9. 2001
    ..We assessed the role of the angiotensin-II-receptor antagonist losartan in patients with type 2 diabetes and nephropathy...
  16. ncbi Recommendations for improving serum creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program
    Gary L Myers
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Clin Chem 52:5-18. 2006
    Reliable serum creatinine measurements in glomerular filtration rate (GFR) estimation are critical to ongoing global public health efforts to increase the diagnosis and treatment of chronic kidney disease (CKD)...
  17. ncbi Creatine and creatinine metabolism
    M Wyss
    F Hoffmann La Roche, Vitamins and Fine Chemicals Division, Basel, Switzerland
    Physiol Rev 80:1107-213. 2000
    The goal of this review is to present a comprehensive survey of the many intriguing facets of creatine (Cr) and creatinine metabolism, encompassing the pathways and regulation of Cr biosynthesis and degradation, species and tissue ..
  18. pmc Cystatin C versus creatinine in determining risk based on kidney function
    Michael G Shlipak
    Division of General Internal Medicine, San Francisco Veterans Affairs Medical Center, and Department of Medicine, University of California San Francisco, San Francisco, USA
    N Engl J Med 369:932-43. 2013
    Adding the measurement of cystatin C to that of serum creatinine to determine the estimated glomerular filtration rate (eGFR) improves accuracy, but the effect on detection, staging, and risk classification of chronic kidney disease ..
  19. ncbi Factors influencing serum cystatin C levels other than renal function and the impact on renal function measurement
    Eric L Knight
    Channing Laboratory, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 65:1416-21. 2004
    It is well known that serum creatinine may be used as a marker of renal function only if taking into account factors that influence creatinine production, such as age, gender, and weight...
  20. ncbi Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
    E J Lewis
    Department of Medicine, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL 60612, USA
    N Engl J Med 345:851-60. 2001
    ..the groups with regard to the time to the primary composite end point of a doubling of the base-line serum creatinine concentration, the development of end-stage renal disease, or death from any cause...
  21. pmc Performance of creatinine and cystatin C GFR estimating equations in an HIV-positive population on antiretrovirals
    Lesley A Inker
    Tufts Medical Center, Boston, MA, USA
    J Acquir Immune Defic Syndr 61:302-9. 2012
    To evaluate the performance of Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine, cystatin C, and creatinine-cystatin C estimating equations in HIV-positive patients.
  22. doi Accuracy of the MDRD (Modification of Diet in Renal Disease) study and CKD-EPI (CKD Epidemiology Collaboration) equations for estimation of GFR in the elderly
    Hannah S Kilbride
    The Kent Kidney Care Centre, East Kent Hospitals University NHS Foundation Trust, Canterbury, Kent, United Kingdom
    Am J Kidney Dis 61:57-66. 2013
    ..filtration rate (GFR) is a measure of kidney function, commonly estimated using equations that adjust serum creatinine concentration for age, race, and sex...
  23. pmc Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury
    Kiyoshi Mori
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 115:610-21. 2005
    ..We reveal what we believe to be a novel pathway of iron traffic that is activated in human and mouse renal diseases, and it provides a unique method for their treatment...
  24. ncbi Low-grade albuminuria and incidence of cardiovascular disease events in nonhypertensive and nondiabetic individuals: the Framingham Heart Study
    Johan Arnlov
    Framingham Heart Study, National Heart, Lung and Blood Institute, Bethesda, MD, USA
    Circulation 112:969-75. 2005
    ..Data are limited with regard to the relations of low-grade albuminuria (below the microalbuminuria threshold) and incidence of cardiovascular disease (CVD) events in nondiabetic, nonhypertensive individuals...
  25. ncbi Effect of treatment of hyperuricemia with allopurinol on blood pressure, creatinine clearence, and proteinuria in patients with normal renal functions
    Mehmet Kanbay
    35 Sokak, 81 5, Bahcelievler, Ankara, 06490, Turkey
    Int Urol Nephrol 39:1227-33. 2007
    ..We therefore conducted a prospective study to investigate the benefits of allopurinol treatment in hyperuricemic patients with normal renal function...
  26. ncbi International comparison of the relationship of chronic kidney disease prevalence and ESRD risk
    Stein I Hallan
    Department of Medicine, Division of Nephrology, St Olav University Hospital, N 7006 Trondheim, Norway
    J Am Soc Nephrol 17:2275-84. 2006
    ..In conclusion, CKD prevalence in Norway was similar to that in the United States, suggesting that lower progression to ESRD rather than a smaller pool of individuals at risk accounts for the lower incidence of ESRD in Norway...
  27. pmc Detection of chronic kidney disease with creatinine, cystatin C, and urine albumin-to-creatinine ratio and association with progression to end-stage renal disease and mortality
    Carmen A Peralta
    Department of Medicine, San Francisco VA Medical Center, San Francisco, California, USA
    JAMA 305:1545-52. 2011
    ..A triple-marker approach for chronic kidney disease (CKD) evaluation has not been well studied...
  28. pmc Measured GFR does not outperform estimated GFR in predicting CKD-related complications
    Chi yuan Hsu
    Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    J Am Soc Nephrol 22:1931-7. 2011
    ..the cross-sectional associations between known complications of CKD and iGFR, eGFR estimated from serum creatinine (eGFR_Cr), and eGFR estimated from cystatin C (eGFR_cysC)...
  29. pmc Epidemiology and prognostic significance of chronic kidney disease in the elderly--the Three-City prospective cohort study
    Benedicte Stengel
    Inserm U1018, CESP, Villejuif, France
    Nephrol Dial Transplant 26:3286-95. 2011
    ..Little is known about normal kidney function level and the prognostic significance of low estimated glomerular filtration rate (eGFR) in the elderly...
  30. pmc Relative performance of the MDRD and CKD-EPI equations for estimating glomerular filtration rate among patients with varied clinical presentations
    Kazunori Murata
    Mayo Clinic Division of Nephrology and Hypertension, 200 First Street SW, Rochester, MN 55905, USA
    Clin J Am Soc Nephrol 6:1963-72. 2011
    ..The objective of our study was to compare the accuracy of the MDRD and CKD-EPI equations for estimating GFR in a large group of patients having GFR measurements for diverse clinical indications...
  31. doi Urinary creatinine excretion, an indirect measure of muscle mass, is an independent predictor of cardiovascular disease and mortality in the general population
    Leendert H Oterdoom
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Atherosclerosis 207:534-40. 2009
    ..We aimed to determine whether muscle mass, as reflected by 24h urinary creatinine excretion, is associated with CVD and whether this depends on insulin resistance.
  32. doi Early intervention with erythropoietin does not affect the outcome of acute kidney injury (the EARLYARF trial)
    Zoltan H Endre
    Christchurch Kidney Research Group, Department of Medicine, University of Otago, Christchurch, New Zealand
    Kidney Int 77:1020-30. 2010
    ..3, with a primary outcome of relative average plasma creatinine increase from baseline over 4 to 7 days. Of 529 patients, 162 were randomized within an average of 3...
  33. pmc Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Kidney Int 78:486-94. 2010
    ..such as albumin and other markers of kidney injury, are frequently reported as a normalized ratio to urinary creatinine (UCr) concentration [UCr] to control for variations in urine flow rate...
  34. ncbi Acute kidney injury, mortality, length of stay, and costs in hospitalized patients
    Glenn M Chertow
    Division of Nephrology, Department of Medicine, University of California San Francisco, 94118 1211, USA
    J Am Soc Nephrol 16:3365-70. 2005
    ..of 19,982 adults who were admitted to an urban academic medical center, including 9210 who had two or more serum creatinine (SCr) determinations, was evaluated...
  35. pmc Renal function equations before and after living kidney donation: a within-individual comparison of performance at different levels of renal function
    Hilde Tent
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, Groningen, Netherlands
    Clin J Am Soc Nephrol 5:1960-8. 2010
    ..Whether this is due to the level of GFR as such or to differences in individual characteristics between healthy individuals and patient with chronic kidney disease (CKD) is unknown...
  36. doi Effects of chronic lithium treatment on renal function
    John Tredget
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, United Kingdom
    J Affect Disord 126:436-40. 2010
    ..A review of the literature suggests that ESRD is a very rare side effect, caused after very long-term lithium treatment, and that it might be preventable if lithium is stopped early...
  37. pmc Autologous mesenchymal stromal cells and kidney transplantation: a pilot study of safety and clinical feasibility
    Norberto Perico
    Transplant Research Center Chiara Cucchi de Alessandri e Gilberto Crespi, Department of Immunology and Transplantation, Ospedali Riuniti di Bergamo, Mario Negri Institute for Pharmacological Research, Centro Anna Maria Astori, Parco Scientifico Tecnologico Kilometro Rosso, via Stezzano 87, 24126 Bergamo, Italy
    Clin J Am Soc Nephrol 6:412-22. 2011
    ..Mesenchymal stromal cells (MSCs) abrogate alloimmune response in vitro, suggesting a novel cell-based approach in transplantation. Moving this concept toward clinical application in organ transplantation should be critically assessed...
  38. pmc Nonrecovery of kidney function and death after acute on chronic renal failure
    Chi yuan Hsu
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    Clin J Am Soc Nephrol 4:891-8. 2009
    ..Relatively little is known about clinical outcomes, especially long-term outcomes, among patients who have chronic kidney disease (CKD) and experience superimposed acute renal failure (ARF; acute on chronic renal failure)...
  39. ncbi Calibration of serum creatinine in the National Health and Nutrition Examination Surveys (NHANES) 1988-1994, 1999-2004
    Elizabeth Selvin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
    Am J Kidney Dis 50:918-26. 2007
    The calibration of serum creatinine values to standardized creatinine and the commutability of serum creatinine across surveys are essential to the correct use of National Health and Nutrition Examination Survey (NHANES) data for kidney ..
  40. doi Acute kidney injury and outcomes in acute decompensated heart failure: evaluation of the RIFLE criteria in an acutely ill heart failure population
    Noritake Hata
    Division of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School, 1715 Kamagari, Inbamura, Inbagun, Chiba 270 1694, Japan
    Eur J Heart Fail 12:32-7. 2010
    ..We therefore investigated the relationship between the prognosis of ADHF and acute kidney injury (AKI) evaluated using the risk, injury, failure, loss, end stage (RIFLE) criteria...
  41. ncbi Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment
    E Coll
    Services of Nephrology, Biochemistry, Statistics, and Nuclear Medicine, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Spain
    Am J Kidney Dis 36:29-34. 2000
    ..mass, it has been postulated to be an improved marker of glomerular filtration rate (GFR) compared with serum creatinine level...
  42. ncbi Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery
    C R Parikh
    Section of Nephrology, Yale University, New Haven, Connecticut 06516, USA
    Kidney Int 70:199-203. 2006
    ..immunosorbent assay for IL-18 in 20 patients who developed AKI (defined as a 50% or greater increase in serum creatinine after CPB) and 35 controls (age, race, and gender-matched patients who did not develop AKI after CPB)...
  43. pmc Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study
    Michael Bennett
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH 45229 3039, USA
    Clin J Am Soc Nephrol 3:665-73. 2008
    ..In this study, whether an NGAL immunoassay developed for a standardized clinical platform (ARCHITECT analyzer, Abbott Diagnostics Division, Abbott Laboratories, Abbott Park, IL) can predict AKI after CPB was tested...
  44. ncbi Evaluation of the modification of diet in renal disease study equation in a large diverse population
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, 750 Washington Street, Box 391, Boston, MA 02111, USA
    J Am Soc Nephrol 18:2749-57. 2007
    ..a cross-sectional analysis of 5504 participants in 10 studies that included measurements of standardized serum creatinine and urinary clearance of iothalamate. At eGFR <60 ml/min per 1...
  45. ncbi Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children--a meta-analysis
    Juliana F Roos
    School of Pharmacy, University of Queensland, Brisbane, QLD 4072, Australia
    Clin Biochem 40:383-91. 2007
    ..To perform a systematic review comparing the diagnostic accuracy of CysC with SCr...
  46. ncbi Increased urinary albumin excretion, endothelial dysfunction, and chronic low-grade inflammation in type 2 diabetes: progressive, interrelated, and independently associated with risk of death
    Coen D A Stehouwer
    Department of Internal Medicine and Institute for Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Diabetes 51:1157-65. 2002
    ..determined by baseline levels of and the longitudinal development of BMI, systolic blood pressure, serum creatinine, glycated hemoglobin and plasma von Willebrand factor (baseline only), soluble E-selectin (baseline only), ..
  47. doi Prevalence of chronic kidney disease in the Japanese general population
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Clin Exp Nephrol 13:621-30. 2009
    ..We re-estimated the prevalence of CKD by measuring proteinuria using a dipstick test and by calculating the GFR using a new equation that estimates GFR based on data from the Japanese annual health check program in 2005...
  48. ncbi The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes
    H H Parving
    Steno Diabetes Center, Copenhagen, Denmark
    N Engl J Med 345:870-8. 2001
    ..02). CONCLUSIONS: Irbesartan is renoprotective independently of its blood-pressure-lowering effect in patients with type 2 diabetes and microalbuminuria...
  49. ncbi A comparison between cystatin C, plasma creatinine and the Cockcroft and Gault formula for the estimation of glomerular filtration rate
    Frans J Hoek
    Academic Medical Center, Department of Clinical Chemistry, Room F1 219, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Nephrol Dial Transplant 18:2024-31. 2003
    In clinical practice, the glomerular filtration rate (GFR) is often estimated from plasma creatinine. Several studies have shown cystatin C (cys C) to be a better parameter for the diagnosis of impaired renal function...
  50. ncbi Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis
    Vikas R Dharnidharka
    Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610 0296, USA
    Am J Kidney Dis 40:221-6. 2002
    ..However, there are conflicting reports regarding the superiority of Cys C over serum creatinine (Cr), with a few studies suggesting no significant difference.
  51. ncbi Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine
    M Tepel
    Medizinische Klinik I, Universitatsklinik Marienhospital, Ruhr Universitat Bochum, Herne, Germany
    N Engl J Med 343:180-4. 2000
    ..Radiographic contrast agents can cause a reduction in renal function that may be due to reactive oxygen species. Whether the reduction can be prevented by the administration of antioxidants is unknown...
  52. pmc Serum creatinine level, a surrogate of muscle mass, predicts mortality in peritoneal dialysis patients
    Jongha Park
    Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine, School of Medicine, Orange, CA, USA
    Nephrol Dial Transplant 28:2146-55. 2013
    In hemodialysis patients, higher serum creatinine (Cr) concentration represents larger muscle mass and predicts greater survival. However, this association remains uncertain in peritoneal dialysis (PD) patients.
  53. doi Meta-analysis: serum creatinine changes following contrast enhanced CT imaging
    Judith Kooiman
    Department of Thrombosis and Haemostasis, LUMC, Leiden, The Netherlands
    Eur J Radiol 81:2554-61. 2012
    ..Secondly, we aimed to identify subgroups at increased risk for CIN...
  54. ncbi N-acetylcysteine and contrast-induced nephropathy in primary angioplasty
    Giancarlo Marenzi
    Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico, Institute of Cardiology, University of Milan, Milan, Italy
    N Engl J Med 354:2773-82. 2006
    ..We investigated the antioxidant N-acetylcysteine for the prevention of contrast-medium-induced nephropathy in patients undergoing primary angioplasty...
  55. doi The association of albuminuria, arterial stiffness, and blood pressure status in nondiabetic, nonhypertensive individuals
    Byung Jin Kim
    Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea
    J Hypertens 29:2091-8. 2011
    ..Although several studies have reported an association between microalbuminuria and pulse wave velocity in patients with hypertension or diabetes, there have been no reports of their significance in apparently healthy individuals...
  56. pmc Lower serum creatinine is a new risk factor of type 2 diabetes: the Kansai healthcare study
    Nobuko Harita
    Department of Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, Japan
    Diabetes Care 32:424-6. 2009
    ..Serum creatinine is a possible surrogate marker of skeletal muscle mass...
  57. doi Serum creatinine improves body mass index survival prediction in hemodialysis patients: a 1-year prospective cohort analysis from the ARNOS study
    Xavier Moreau-Gaudry
    Département de Hémodialyse, Agduc Porte de Provence, Montelimar, France
    J Ren Nutr 21:369-75. 2011
    This study sought to better characterize the relationships between body mass index (BMI) and lean body mass (LBM) as assessed by serum creatinine (SCr) and mortality.
  58. doi Factors other than glomerular filtration rate affect serum cystatin C levels
    Lesley A Stevens
    Division of Nephrology, Clinical Care Research, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 75:652-60. 2009
    ..The serum cystatin C and creatinine levels were related to clinical and biochemical parameters and errors-in-variables models were used to account ..
  59. doi Evaluation of serum creatinine- and cystatin C-based equations for the estimation of glomerular filtration rate in a Chinese population
    Xiao hua Pei
    Division of Nephrology, Department of Geriatrics, School of Public Health, Nanjing Medical University, Nanjing, PR China
    Scand J Urol Nephrol 46:223-31. 2012
    This study aimed to evaluate the applicability of a selection of glomerular filtration rate (GFR) estimating equations based on serum creatinine (SCr) and serum cystatin C in a Chinese population.
  60. pmc Evaluating the performance of equations for estimating glomerular filtration rate
    Lesley A Stevens
    Tufts University School of Medicine, Tufts Medical Center, 800 Washington Street, Box 391 Boston, MA 02111, USA
    J Nephrol 21:797-807. 2008
    ..on distinction between bias, precision and accuracy, and with reference to examples of published evaluations of creatinine- and cystatin C-based equations; explanation of errors in GFR estimates; and challenges and questions in ..
  61. pmc Creatinine, diet, micronutrients, and arsenic methylation in West Bengal, India
    Arin Basu
    Arsenic Health Effects Research Group, School of Public Health, University of California, Berkeley, California 94720, USA
    Environ Health Perspect 119:1308-13. 2011
    ..Methylation may have an important role in arsenic toxicity, because the monomethylated trivalent metabolite [MMA(III)] is highly toxic...
  62. pmc Kidney function estimated from serum creatinine and cystatin C and peripheral arterial disease in NHANES 1999-2002
    Elizabeth Selvin
    Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
    Eur Heart J 30:1918-25. 2009
    Serum cystatin C, a novel marker of kidney function, is reported to be superior to serum creatinine as a risk factor for atherosclerotic disease, but associations may vary across vascular beds.
  63. ncbi Using serum creatinine to estimate glomerular filtration rate: accuracy in good health and in chronic kidney disease
    Andrew D Rule
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Intern Med 141:929-37. 2004
    ..Modification of Diet in Renal Disease (MDRD) equation to estimate glomerular filtration rate (GFR) from serum creatinine measurements in clinical laboratories...
  64. ncbi Expressing the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate with standardized serum creatinine values
    Andrew S Levey
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Clin Chem 53:766-72. 2007
    We sought to reexpress the 4-variable Modification of Diet in Renal Disease (MDRD) Study equation for estimation of glomerular filtration rate (GFR) using serum creatinine (S(cr)) standardized to reference methods.
  65. doi Creatinine fluctuation has a greater effect than the formula to estimate glomerular filtration rate on the prevalence of chronic kidney disease
    Simon de Lusignan
    Division of Community Health Sciences, St George s, University of London, London, UK
    Nephron Clin Pract 117:c213-24. 2011
    ..This study set out to promote a systematic approach to reporting CKD prevalence...
  66. pmc Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies
    Vishal S Vaidya
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Biotechnol 28:478-85. 2010
    ..Whereas histopathology remains the gold standard for nephrotoxicity in animal systems, serum creatinine (SCr) and blood urea nitrogen (BUN) are the primary options for monitoring kidney dysfunction in humans...
  67. doi Cystatin C: current position and future prospects
    Sophie Séronie-Vivien
    Departement de Biologie Clinique, Institut Claudius Regaud, Universite Paul Sabatier, Toulouse, France
    Clin Chem Lab Med 46:1664-86. 2008
    ..C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of cystatin C is mainly determined by glomerular filtration and is particularly of ..
  68. ncbi Does the ID-MS traceable MDRD equation work and is it suitable for use with compensated Jaffe and enzymatic creatinine assays?
    Susan Vickery
    Department of Clinical Biochemistry, East Kent Hospitals NHS Trust, Kent and Canterbury Hospital, Canterbury, Kent CT1 3NG, UK
    Nephrol Dial Transplant 21:2439-45. 2006
    International recommendations suggest that measurement of serum creatinine should be supplemented with an estimate of glomerular filtration rate (GFR) using the Modification of Diet in Renal Disease (MDRD) study equation...
  69. ncbi Monitoring of glomerular filtration rate in lithium-treated outpatients--an ambulatory laboratory database surveillance
    Nader Bassilios
    Réseau Néphropar and Nephrology Department, AP HP, Necker Hospital, Paris, France
    Nephrol Dial Transplant 23:562-5. 2008
    ..The long-term risk of chronic kidney disease (CKD) in lithium (Li)-treated patients has been well established in the recent years...
  70. pmc Risk factors for end-stage renal disease: 25-year follow-up
    Chi yuan Hsu
    Department of Medicine, University of California, San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0532, USA
    Arch Intern Med 169:342-50. 2009
    ..Few cohort studies have focused on risk factors for end-stage renal disease (ESRD). This investigation evaluated the prognostic value of several potential novel risk factors for ESRD after considering established risk factors...
  71. doi Estimating equations for glomerular filtration rate in the era of creatinine standardization: a systematic review
    Amy Earley
    Tufts Medical Center, Boston, MA 02111, USA
    Ann Intern Med 156:785-95, W-270, W-271, W-272, W-273, W-274, W-275, W-276, W-277, W-278. 2012
    Clinical laboratories are increasingly reporting estimated glomerular filtration rate (GFR) by using serum creatinine assays traceable to a standard reference material.
  72. ncbi Cystatin C: an improved estimator of glomerular filtration rate?
    Omar F Laterza
    Washington University School of Medicine, Department of Pathology and Immunology, Division of Laboratory Medicine, Box 8118, 660 S Euclid Ave, St Louis, MO 63110, USA
    Clin Chem 48:699-707. 2002
    ..assessed by measuring the concentrations of endogenous serum markers such as blood urea nitrogen and serum creatinine (SCr)...
  73. ncbi Glomerular filtration rate estimated by cystatin C among different clinical presentations
    A D Rule
    Division of Nephrology, Mayo Clinic, Rochester, Minnesota, USA
    Kidney Int 69:399-405. 2006
    Glomerular filtration rate (GFR) estimates from serum creatinine has not been generalizable across all populations. Cystatin C has been proposed as an alternative marker for estimating GFR...
  74. doi Long-term prognosis of acute kidney injury after acute myocardial infarction
    Chirag R Parikh
    Department of Medicine, Clinical Epidemiology Research Center, Veterans Affairs Medical Center, West Haven, Connecticut 06516, USA
    Arch Intern Med 168:987-95. 2008
    ..Acute kidney injury (AKI) is a common complication during hospitalization and is an accepted risk factor for in-hospital mortality. However, the association of severity of AKI with the long-term risk of death is not well defined...
  75. doi Comparison of serum creatinine and cystatin C for early diagnosis of contrast-induced nephropathy after coronary angiography and interventions
    Flavio Ribichini
    Department of Medicine, Division of Cardiology, University of Verona, Verona, Italy
    Clin Chem 58:458-64. 2012
    The diagnostic accuracy of serum creatinine and cystatin C (Cys) as early predictors of contrast-induced nephropathy (CIN) has been debated...
  76. ncbi Minimal changes of serum creatinine predict prognosis in patients after cardiothoracic surgery: a prospective cohort study
    Andrea Lassnigg
    Department of Cardiothoracic Anesthesia and Intensive Care Medicine, University Hospital of Vienna, Waehrihger Guertel 18 20, A 1090 Vienna, Austria
    J Am Soc Nephrol 15:1597-605. 2004
    ..Thus, the association between small serum creatinine changes after surgery and mortality, independent of other established perioperative risk indicators, was ..
  77. pmc Central obesity, incident microalbuminuria, and change in creatinine clearance in the epidemiology of diabetes interventions and complications study
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, Washington 98195, USA
    J Am Soc Nephrol 18:235-43. 2007
    ..Whether waist circumference is associated with incident microalbuminuria and change in creatinine clearance was examined among 1279 participants who had type 1 diabetes and were enrolled in the Epidemiology of ..
  78. ncbi Risk factors and clinical outcomes for contrast-induced nephropathy after percutaneous coronary intervention in patients with normal serum creatinine
    Eric Chong
    Alexandra Hospital Cardiac Department National University Heart Centre, National University Hospital, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Ann Acad Med Singapore 39:374-80. 2010
    ..We aim to examine the risk predictors of contrast-induced nephropathy (CIN) in patients with normal baseline serum creatinine (Cr). CIN is an important complication postpercutaneous coronary intervention (PCI)...
  79. doi Performance of creatinine-based equations compared in older patients
    Laetitia Koppe
    Nephrology Department, Hospital E Herriot, HCL, Lyon, France
    J Nephrol 26:716-23. 2013
    ....
  80. pmc Biomarkers predict progression of acute kidney injury after cardiac surgery
    Jay L Koyner
    Section of Nephrology, Department of Medicine, University of Chicago, Pritzker School of Medicine, Illinois, USA
    J Am Soc Nephrol 23:905-14. 2012
    ..Biomarkers included urinary IL-18, urinary albumin to creatinine ratio (ACR), and urinary and plasma neutrophil gelatinase-associated lipocalin (NGAL); each measurement was on ..
  81. doi AKI in the ICU: definition, epidemiology, risk stratification, and outcomes
    Kai Singbartl
    Department of Critical Care Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 81:819-25. 2012
    ..Even small changes in serum creatinine concentrations are associated with a substantial increase in the risk of death...
  82. pmc Use of multiple imputation method to improve estimation of missing baseline serum creatinine in acute kidney injury research
    Edward D Siew
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, 116121st Avenue South, Nashville, TN 37232 2372, USA
    Clin J Am Soc Nephrol 8:10-8. 2013
    Baseline creatinine (BCr) is frequently missing in AKI studies. Common surrogate estimates can misclassify AKI and adversely affect the study of related outcomes...
  83. pmc Trends in the prevalence of reduced GFR in the United States: a comparison of creatinine- and cystatin C-based estimates
    Morgan E Grams
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Kidney Dis 62:253-60. 2013
    The US prevalence of reduced estimated glomerular filtration rate (eGFR) based on serum creatinine level increased during the decade ending in 2002...
  84. doi Estimation of the age-dependent decline of glomerular filtration rate from formulas based on creatinine and cystatin C in the general elderly population
    Anders Christensson
    Division of Nephrology and Transplantation, Department of Clinical Sciences, Malmo University Hospital, Malmo, Sweden Anders christensson med lu se
    Nephron Clin Pract 117:c40-50. 2011
    To evaluate the performance of estimation formulas for glomerular filtration rate (GFR) based on creatinine and cystatin C in elderly.
  85. pmc Comparison of urinary albumin-creatinine ratio and albumin excretion rate in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study
    Naji Younes
    Biostatistics Center, George Washington University, 6110 Executive Boulevard, Suite 700, Rockville, MD 20852 USA
    Clin J Am Soc Nephrol 5:1235-42. 2010
    The objective of this study was to compare random urine albumin-creatinine ratio (ACR) with timed urine albumin excretion rate (AER) in patients with type 1 diabetes.
  86. pmc Using mathematical algorithms to modify glomerular filtration rate estimation equations
    Xiaohua Pei
    Division of Nephrology, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
    PLoS ONE 8:e57852. 2013
    ..Thus, this study was designed to modify the three equations, and compare the diagnostic accuracy of the equations modified before and after...
  87. ncbi A longitudinal study of urinary creatinine and creatinine clearance in normal subjects. Race, sex, and age differences
    G D James
    Cardiovascular Center, New York Hospital-Cornell University Medical College, NY 10021
    Am J Hypertens 1:124-31. 1988
    The purpose of this study was to examine the variability of 24-hour urinary and serum creatinine levels and creatinine clearance in normal subjects and to develop nomograms for assessing the adequacy of 24-hour urine collections...
  88. ncbi The risk of developing end-stage renal disease in patients with type 2 diabetes and nephropathy: the RENAAL study
    William F Keane
    Department of Medicine, Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Kidney Int 63:1499-507. 2003
    ..We examined the risk factors that predict loss of kidney function (doubling of serum creatinine) or ESRD (dialysis or transplantation) in patients with type 2 diabetes in whom blood pressure was controlled.
  89. pmc Rapid kidney function decline and mortality risk in older adults
    Dena E Rifkin
    Division of Nephrology, Tufts Medical Center, 750 Washington St, Box 391, Boston, MA 02111, USA
    Arch Intern Med 168:2212-8. 2008
    ..It remains unknown, however, whether longitudinal declines in kidney function are independently associated with increased cardiovascular and all-cause mortality in older adults...
  90. ncbi Monitoring renal function: measured and estimated glomerular filtration rates - a review
    J V Salgado
    Departamento de Ciencias Farmaceuticas, Universidade de Brasilia, DF, Brasil
    Braz J Med Biol Res 43:528-36. 2010
    ..Blood creatinine clearance, the most widely used clinical marker of kidney function, is now recognized as an unreliable measure ..
  91. pmc Selective renal overexpression of human heat shock protein 27 reduces renal ischemia-reperfusion injury in mice
    Minjae Kim
    Departments of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032 3784, USA
    Am J Physiol Renal Physiol 299:F347-58. 2010
    ..Mice with kidney-specific reconstitution of huHSP27 had significantly lower plasma creatinine, renal necrosis, apoptosis, and inflammation as demonstrated by decreased proinflammatory cytokine mRNA ..
  92. doi Comparison of plasma clearance of iohexol and urinary clearance of inulin for measurement of GFR in children
    Ulla B Berg
    Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Am J Kidney Dis 57:55-61. 2011
    ..Very few studies have been published that compare plasma clearance of iohexol (Cio) with renal clearance of inulin (Cin)...
  93. doi Urine C-peptide creatinine ratio is an alternative to stimulated serum C-peptide measurement in late-onset, insulin-treated diabetes
    A G Jones
    Peninsula NIHR Clinical Research Facility, Peninsula Medical School, University of Exeter, Exeter, UK
    Diabet Med 28:1034-8. 2011
    ..Urine C-peptide creatinine ratio may be a non-invasive practical alternative...
  94. doi Focusing on the clinical impact of standardization of creatinine measurements: a report by the EFCC Working Group on Creatinine Standardization
    Joris R Delanghe
    Department of Clinical Chemistry, University Hospital, Gent, Belgium
    Clin Chem Lab Med 49:977-82. 2011
    The recent campaign for standardization of creatinine measurements has been promoted to allow the widespread use of formulas for estimating the glomerular filtration rate (GFR)...
  95. pmc High activity of indoleamine 2,3-dioxygenase is associated with renal insufficiency in Puumala hantavirus induced nephropathia epidemica
    Tuula K Outinen
    Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    J Med Virol 83:731-7. 2011
    ..Serum kynurenine, tryptophan, creatinine, CRP, and blood cell count were measured for up to 5 consecutive days after admission...
  96. ncbi Elevated admission serum creatinine predicts poor myocardial blood flow and one-year mortality in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention
    Lin Zhao
    Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, No 95 Yong an Road, Xuanwu District, Beijing, 100050, China
    J Invasive Cardiol 21:493-8. 2009
    ..However, data regarding admission serum creatinine and coronary and myocardial flow are scant...
  97. pmc Performance of the Cockcroft-Gault, MDRD, and new CKD-EPI formulas in relation to GFR, age, and body size
    Wieneke Marleen Michels
    Division of Nephrology, Department of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Clin J Am Soc Nephrol 5:1003-9. 2010
    ....
  98. doi Is the Chronic Kidney Disease Epidemiology Collaboration four-level race equation better than the cystatin C equation?
    Xin Du
    Department of Nephrology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, China
    Nephrology (Carlton) 17:407-14. 2012
    ..rate (GFR) in Chinese people with chronic kidney disease (CKD), which was published in 2011, compared with the cystatin C-based GFR estimation equation (CysC GFR) and the combination of CysC and serum creatinine equation (CysC-Scr GFR).
  99. pmc Reference values for serum creatinine in children younger than 1 year of age
    Dirk P Boer
    Department of Paediatric Nephrology, Erasmus MC Sophia Children s Hospital, Erasmus University Medical Center, Dr Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands
    Pediatr Nephrol 25:2107-13. 2010
    Reliable reference values of enzymatically assayed serum creatinine categorized in small age intervals are lacking in young children...
  100. ncbi A simplified method for HPLC determination of creatinine in mouse serum
    Peter S T Yuen
    Renal Diagnostics and Therapeutics Unit, NIDDK, NIH, 10 Center Dr, Rm 3N108, Bethesda, MD 20892 1268, USA
    Am J Physiol Renal Physiol 286:F1116-9. 2004
    ..However, mouse serum contains chromagens that interfere with standard picric acid-based assays for serum creatinine. Several alternative methods exist for serum creatinine measurements, including assay by high-performance liquid ..
  101. ncbi Environmental lead exposure and progressive renal insufficiency
    J L Lin
    Poison Center and Division of Nephrology, Chang Gung Memorial Hospital, 199, Tung Hwa North Road, Taipei, Taiwan, Republic of China
    Arch Intern Med 161:264-71. 2001
    Several recent studies show that serum creatinine level or creatinine clearance is inversely associated with blood lead levels. However, the studies did not allow direct inferences about causality.

Research Grants67

  1. Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: Preclinic
    Yasmin Wadia; Fiscal Year: 2013
    ..leak;d) damage to the kidney parenchyma evident by compromised renal function or long term renal function via creatinine clearance and MAG3 nuclear renal scan and e) mortality...
  2. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..and adiposity (insulin, C-peptide, adiponectin, leptin, resistin, liver function enzymes);(3) renal function (creatinine, cystatin C, ADMA, uric acid, 25(OH)vitamin D, parathyroid hormone);and (4) inflammation and hemostasis (hsCRP, ..
  3. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..ratio), neutrophil infiltration, 3- nitrotyrosine (3-NT), nitrite/nitrate, and poly(ADP-ribose) formation, BUN, creatinine, NGAL, AST, ALT, histology injury score, and serum concentrations of TNF-1, HMGB-1, IL-6, TRP14, Trx1, LC8, I:B1,..
  4. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
    ..in a rodent model of renal ischemia/reperfusion injury R- 801 profoundly reduced the elevation in BUN and creatinine, blocked neutrophil inflammation, and prevented histologic evidence of necrosis...
  5. Early Life Conditions, Survival, and Health: A Pedigree-Based Population Study
    Ken R Smith; Fiscal Year: 2013
    ..Biomarker measures studied include C-reactive protein, white blood count, albumin, uric acid, creatinine, serum cholesterol, glycosylated hemoglobin, dehydroepiandrosterone sulfate (DHEAS &DHEA), fasting glucose ..
  6. METABOLISM, MICRONUTRIENTS, AND ANTIRETROVIRAL THERAPY OUTCOMES IN ZAMBIA
    DOUGLAS CORBETT HEIMBURGER; Fiscal Year: 2010
    ..serum samples we will measure additional metabolic analytes (sodium, chloride, bicarbonate, urea nitrogen, and creatinine), selected micronutrients (ferritin for iron status, folic acid, vitamins A, B12, and E, and selenium), and ..
  7. New drug Vida-5 for treating chronic kidney disease progression
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2011
    ..animal study to show the synergistic effect of Vida-5 and an ACE inhibitor on reducing biomarkers (such as serum creatinine and proteinuira) indicative of kidney disease progression;(2) to conduct a toxicity animal study to prepare Vida-..
  8. Clinical and genomic responses to remote ischemic preconditioning
    Brian W McCrindle; Fiscal Year: 2010
    ..These measures will include indices of renal (urine output, urea, creatinine), cardiac (troponin I, inotrope score), pulmonary (pulmonary and airway mechanics, ventilation parameters), ..
  9. Effect of Ultrafiltration on Clinical Outcomes and Health-related Quality of Life
    KELLY VICTORIA LIANG; Fiscal Year: 2013
    ..Worsening renal function, typically defined as a rise in serum creatinine of e 0.3 mg/dL, is associated with worse outcomes, chronic volume overload, and worse HRQOL...
  10. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2012
    ..complement on this spontaneous model of lupus will be ascertained using disease measures (proteinuria, creatinine, blood urea nitrogen and renal pathology), autoantibodies and immune responses...
  11. Central Biochemistry Laboratory of the CKiD Consortium
    George J Schwartz; Fiscal Year: 2013
    ..Blood analytes include electrolytes, BUN, creatinine, glucose, calcium, phosphorus, albumin, uric acid, lipid screen, hsCRP, intact PTH, and cystatin C...
  12. Predicting persistent Organ Failure early in Acute Pancreatitis
    Georgios I Papachristou; Fiscal Year: 2013
    ..this same cohort, we will calculate the accuracy of 5 single markers (glucose, hematocrit, blood urea nitrogen, creatinine, and C-reactive protein) and 7 scoring systems (Ranson's, acute physiology and chronic health examination-..
  13. Mechanisms of tubular atrophy in renal disease
    Jeffrey R Schelling; Fiscal Year: 2012
    ..by histochemical staining for triacylglycerol, apoptosis, and interstitial fibrosis;for renal function by serum creatinine and uine albumin: creatinine ratios;for ex vivo NHE1 activity by fluorescence methods...
  14. Mediators &prognostic value of muscle mass &function in chronic kidney disease
    Francis Perry Wilson; Fiscal Year: 2013
    ..Cases will be defined as patients in the highest quintile of longitudinal muscle loss as assessed by slope of creatinine generation rate over time...
  15. Role of Meprin A in Acute Kidney Injury
    GUR PRASAD KAUSHAL; Fiscal Year: 2013
    ..fragments, undetectable in the urine of normal mice, increased significantly before the rise in serum creatinine during the progression of IR- and cisplatin- induced AKI...
  16. Radiocontrast Nephropathy: Redox Degradation Catalyst and Nitric Oxide Donor
    ZSUZSANNA KINGA ZSENGELLER; Fiscal Year: 2013
    ..injury (RIRI), IV administration of R-100 prior to reperfusion reduced the 6 h elevations in serum creatinine, serum NGAL, tissue myeloperoxidase, and histologic score by 75-90% (p<10-14) and restored the reduction of ..
  17. Health Information Technology for Chronic Kidney Disease Management
    Lipika Samal; Fiscal Year: 2013
    ..al.;Specific Aim 1a: Develop a search method to find existing urine albumin to creatinine ratio, serum calcium, serum phosphate, serum albumin, and serum bicarbonate values...
  18. Epidemiology of Retinopathy and other Complications in Long Term Type 1 Diabetes
    Michael Y Tsai; Fiscal Year: 2013
    ..g., AGEs [carboxymethyl lysine, pentosidine], soluble RAGE, oxidized low density lipoprotein cholesterol, creatinine) according to standardized protocols will be obtained in the proposed examination...
  19. Randomized Trial of a Postpartum Diabetes Prevention Program for Hispanic Women
    Lisa Chasan-Taber; Fiscal Year: 2013
    ..e., blood lipids, blood pressure, CRP, fetuin A, albumin-to-creatinine ratio), and 4) the adoption and maintenance of postpartum behaviors associated with weight loss and prevention ..
  20. Endothelial microparticles in patients with kidney transplants
    Sergey Brodsky; Fiscal Year: 2012
    ..Typically, renal allograft function is evaluated by serum creatinine (SC) levels...
  21. Residual Kidney Function in ESRD: Measurements, Serum Markers and Outcomes
    Tariq Shafi; Fiscal Year: 2013
    ..There are no methods for assessing RKF similar to the estimation of GFR by serum creatinine in non-dialysis patients...
  22. Integrated Cardio-Renal Risk Prediction Models in Type 1 Diabetes
    Marian J Rewers; Fiscal Year: 2010
    ..causes of death among adults with type 1 diabetes, but traditional screening tests (urinary albumin and serum creatinine) for renal disease are inadequate, and traditional CAD risk factors (dyslipidemia, hypertension, smoking, ..
  23. Role of apolipoprotein M in acute kidney injury
    Didier Portilla; Fiscal Year: 2012
    ..We find also increased shedding of urinary ApoM that precedes changes in blood urea nitrogen and serum creatinine in wild type mice as well as human ApoM transgenic mice exposed to cisplatin...
  24. MRI Imaging Biomarkers of ARPKD Kidney and Liver Disease
    Christopher A Flask; Fiscal Year: 2013
    ..Traditional measures of kidney or biliary function (such as serum creatinine or bilirubin) may be normal and/or stable despite ongoing disease progression...
  25. Measurement of Renal Viscoelastic Properties with Ultrasound
    MATTHEW WILLIAM URBAN; Fiscal Year: 2013
    ..Noninvasive indicators of kidney disease including levels of serum creatinine, glomerular filtration rate, and classical medical imaging can provide certain insights into kidney disease ..
  26. Biomarkers of Kidney Pathology
    Sushrut S Waikar; Fiscal Year: 2013
    ..associations of urinary and tissue biomarkers with renal function decline, defined as a doubling of serum creatinine or the need for renal replacement therapy...
  27. Anti-CD47 mAb Therapy to Improve Kidney Transplantation
    PAMELA ANN TOY-MANNING; Fiscal Year: 2011
    ..In both aims, readouts of kidney function (urine production, creatinine, BUN and soluble enzyme release) and cytokine levels will be monitored...
  28. Access to Liver Transplantation for Patients with Primary Sclerosing Cholangitis
    David Seth Goldberg; Fiscal Year: 2011
    ..a patient's Model for End Stage Liver Disease (MELD) score, which accounts for a patient's serum INR, creatinine, and bilirubin...
  29. Randomized trial of vitamin D and omega-3 fatty acids for diabetic kidney disease
    Ian H De Boer; Fiscal Year: 2013
    ..First morning voids will be collected at baseline and year 4 for measurement of urine albumin-creatinine ratio...
  30. Predicting the burden of renal disease among liver transplant recipients
    Pratima Sharma; Fiscal Year: 2013
    ..spectrum of renal dysfunction in the end-stage liver disease candidates varies from slight elevation in serum creatinine from pre-existing renal disease to full blown renal failure from hepatorenal syndrome requiring renal ..
  31. Reversing Non-adherence in American Indians with Diabetes Mellitus Type Two
    Marlene K Wilken; Fiscal Year: 2012
    ..which include HbA1c, blood pressure, weight, body mass index, foot inspection, depression screen, lipid profile, creatinine, liver enzymes, and eye exam...
  32. Pharmacokinetic and Pharmacogenomic Determinants of Cisplatin Kidney Injury
    Melanie S Joy; Fiscal Year: 2013
    ..The proposed studies incorporate traditional measures of clinical nephrotoxicity (serum creatinine, blood urea nitrogen) and a novel biomarker (urinary Kim-1) to detect the phenotype of acute kidney injury...
  33. The Aging Kidney in HIV-Infection: biomarkers for early detection of injury
    Michael G Shlipak; Fiscal Year: 2013
    ..However, a major challenge in clinical practice is the current reliance on serum creatinine and albuminuria testing to detect kidney injury and disease...
  34. TGF-beta1 and Mitochondrial Dysfunction in LPS-Induced Renal Failure
    L Jay Stallons; Fiscal Year: 2013
    ..Glomerular filtration was normal at 18 h but decreased (i.e. elevated serum creatinine) 42 h after LPS injection. Urine output was minimal at 42 h...
  35. Vascular ANGII/Jak2 in progression of renal disease
    Peter P Sayeski; Fiscal Year: 2012
    ..and total NO production and tissues/blood will be harvested for assessment of renal pathology, 24 hour creatinine clearance (Ccr), determinants of NO and ROS production, plasma and renal tissue ANGII and levels of components ..
  36. Subclinical Renal Artery Atherosclerosis, Kidney Function and Hypertension
    Matthew A Allison; Fiscal Year: 2011
    ..The cystatin-C results will be used as a measure of kidney function and compared with existing data on serum creatinine and urine albumin...
  37. Urinary Biomarkers of Chronic Kidney Disease Pathology and Progression
    Sushrut S Waikar; Fiscal Year: 2013
    ..in turn predictive of CKD progression;and that urinary biornarkers are superior to conventional markers (serum creatinine and albuminuria) as predictors of CKD progression...
  38. Native Healthy Lifestyle: A Return to Balance
    ELISA TAN LEE; Fiscal Year: 2010
    ..total triglyceride, HDL-cholesterol, LDL-cholesterol, HbA1c, fasting glucose, blood pressure and urinary albumin/creatinine ratio. 3...
  39. Women's Health Study: Continued Follow-Up
    Julie E Buring; Fiscal Year: 2010
    ..All plasma samples have been assayed for a full lipid panel, high sensitivity C-reactive protein, and creatinine, and are now undergoing extensive phenotyping for additional inflammatory and hematologic markers...
  40. Cardiac and Renal Effects of N-Acetylcysteine
    Markus Meyer; Fiscal Year: 2011
    ..myocardial infarction size (TTC stain), cardiac and renal apoptosis (TUNEL stain), renal function (Creatinine), renal tubular markers of kidney injury and an arrhythmia evaluation (ECG telemetry, electrophysiological ..
  41. Arsenic Exposure, Cardiovascular Disease and Diabetes in Native Americans
    Ana Navas-Acien; Fiscal Year: 2011
    ..Preliminary studies: The sum of inorganic and methylated urine arsenic species ranged from 2.1 to 72.8 5 ug/g creatinine (median 7.2 5 ug/g) in 60 Strong Heart Study Participants selected at random...
  42. The Effects of Frailty on Chronic Kidney Disease
    Cynthia Delgado; Fiscal Year: 2013
    ..First, has the use of estimates of GFR based on serum creatinine led to underestimation of the association between frailty and CKD, given that sarcopenia is an important part of ..
  43. Paracrine Regulation of BPH Pathogeneis
    SIMON HAYWARD; Fiscal Year: 2009
    ..urgency and post-mictural dribbling and, more seriously it can cause renal insufficiency (with rising serum creatinine), frequent urinary tract infections and urosepsis due to insufficient urinary draining...
  44. Paracrine Regulation of BPH Pathogenesis
    Simon W Hayward; Fiscal Year: 2013
    ..urgency and post-mictural dribbling and, more seriously it can cause renal insufficiency (with rising serum creatinine), frequent urinary tract infections and urosepsis due to insufficient urinary draining...
  45. Accurate Measurement of Renal Function in Cirrhosis
    Vivian S Lee; Fiscal Year: 2013
    ..is one of the most important risk factors for mortality in cirrhotics, as reflected by the inclusion of serum creatinine (Cr) in the MELD priority score for transplantation, and yet measures of renal function are highly inaccurate in ..
  46. Associations among RAAS Inhibitors, Residual Kidney Function, and CV Events in PD
    Jenny I Shen; Fiscal Year: 2013
    ..between ACEI or ARB use and preservation of RRF, which will be calculated as the average of the 24 hour creatinine and urea clearances. We hypothesize that ACEI or ARB use will be associated with better preservation of RRF...
  47. In Vivo Assessment of Calcineurin Inhibitor Toxicity in Children
    Joshua M Thurman; Fiscal Year: 2013
    ..are currently unavailable and clinical practice still relies on relatively late and insensitive markers such as creatinine in serum and on invasive methods such as percutaneous kidney biopsies...
  48. Urinary Proteome Monitoring for Transplant Injury
    Minnie M Sarwal; Fiscal Year: 2013
    ..CAN), and viral infection with the BK virus (BKV), which are indistinguishable by simply monitoring the serum creatinine and require an invasive biopsy for diagnosis of established injury...
  49. Environmental exposure to metal mixtures and kidney disease
    Mary Fox; Fiscal Year: 2009
    ..by race/ethnicity or socio- economic status;and (2) those with higher mixture exposure metrics will have reduced creatinine clearance and estimated glomerular filtration rates and increased urinary albumin-creatinine ratios...
  50. Urinary Biomarkers for Recovery After Acute Kidney Injury and Prognosis in Hospit
    ISAAC ELI HALL; Fiscal Year: 2010
    ..AKI in the hospital is frequently unpredictable and most often diagnosed by an increase in serum creatinine (Scr) concentrations on routine daily blood draws...
  51. Hepcidin Lateral Flow Device for Prediction of Acute Kidney Injury
    MARK EDWARD WESTERMAN; Fiscal Year: 2013
    ..Existing renal markers confirming loss of function (e.g. serum creatinine) in AKI are very late markers (1-3 days) for diagnosis of AKI. Few biomarkers (e.g...
  52. Src Family Kinases and Control of Epithelial Cell Paracellular Permeability
    KURT F AMSLER; Fiscal Year: 2012
    ..by measuring parameters reflecting renal functional capacity, glomerular filtration rate (serum/urinary creatinine ratio), and proximal tubule cell structural integrity, Na+-K+-ATPase polarity...
  53. Pre-clinical Testing of GSK3 Inhibitors in ADPKD
    Irina Barash; Fiscal Year: 2010
    ..and in vivo measurements will include longitudinal MRI imaging of cystic development and expansion, BUN and creatinine measurements, as well as kidney/heart weight, pathological and irrimunohistochemical examination of kidney ..
  54. A Triple Marker Approach To Optimize CKD Detection Among Black and White Adults
    CARMEN ALICIA PERALTA; Fiscal Year: 2013
    ..The current clinical strategy among non-diabetics relies on serum creatinine for diagnosing CKD, and this strategy misses many persons at risk. In fact, 1 in 6 adults in the U.S...
  55. Natural History of MYH9-Associated Nephropathy
    BARRY IRA FREEDMAN; Fiscal Year: 2012
    ..with cross-sectional and longitudinal measures of blood pressure, albuminuria, serum cystatin C and creatinine concentrations, and estimated glomerular filtration rates in members of the cohort;and (3) creation of a ..
  56. RENALASE IN ACUTE KIDNEY INJURY: UTILITY AS A BIOMARKER, AND THERAPEUTIC AGENT
    Gary V Desir; Fiscal Year: 2010
    ..of effective treatment protocols for AKI has been hampered by the fact the diagnosis relies heavily of serum creatinine measurements, and is, therefore, often made 48-72 hours following the original insult...
  57. Kidney Function and Aging
    Lesley Ann Inker; Fiscal Year: 2012
    ..b>Creatinine based GFR estimates may not be accurate in older adults as malnutrition and loss of muscle mass, common with age ..
  58. International Population Study on Macronutrients and BP - INTERMAP
    LINDA VERNER VAN HORN; Fiscal Year: 2013
    ..total: 83);two timed 24-hour urine collections/person with measurement of 24-hour volume, Na, K, Ca, Mg, creatinine, urea, macro-/ microalbuminuria, 23 amino acids, nuclear magnetic resonance (NMR) metabolomic scanning for ..
  59. Multi-factorial Intervention to Slow Progression of Diabetic Kidney Disease
    Uptal D Patel; Fiscal Year: 2013
    ..Other analyses will evaluate differences in clinical endpoints (doubling of creatinine, dialysis, death, cardiovascular events, and composite), improved behaviors that affect hypertension control (..
  60. CORAL: Economics and QOL Core Laboratory
    David J Cohen; Fiscal Year: 2013
    ..or renal death, myocardial infarction, hospitalization for congestive heart failure, stroke, doubling of serum creatinine level, and need for renal replacement therapy...
  61. Diagnostic and Prognostic Relevance of Acute Kidney Injury Biomarkers in the ICU
    Edward Siew; Fiscal Year: 2013
    ..e. changes in serum creatinine and urine output) that provide little information on the timing and mechanisms of ongoing injury...
  62. Endothelial Dysfunction in the Pathogenesis of Sickle Cell Nephropathy
    Kenneth I Ataga; Fiscal Year: 2013
    ..More recently, we have found that SCD patients with macroalbuminuria (urine albumin excretion >300 mg/g creatinine) have significantly elevated levels of both soluble vascular cell adhesion molecule-1 (VCAM-1), a measure of ..
  63. MINORITY SCHOOL FACULTY DEVELOPMENT AWARD
    HALCYON WATKINS; Fiscal Year: 1992
    ..The urine samples will be assayed for NE, DA, E, sodium, potassium and creatinine whereas plasma will be assayed for aldosterone, PRA, NE, DA, E and creatinine...
  64. IDENTIFYING HIGH RISK PATIENTS WITH SYNCOPE
    Wishwa Kapoor; Fiscal Year: 1991
    ..The predictors included a history of diabetes mellitus, renal insufficiency (creatinine greater than 2), left ventricular hypertrophy, left bundle branch block and left axis deviation...
  65. Association between the Y chromosome and androgens
    Kathryn Sandberg; Fiscal Year: 2007
    ..Renal function will be evaluated using creatinine clearance and urinary albumin-to-creatinine ratio. 2...
  66. LONGITUDINAL STUDY OF BONE DENSITY IN ANOREXIA NERVOSA
    MICHAEL PERTSCHUK; Fiscal Year: 1993
    ..serum pregnancy test, estradiol, 25-OH-Vit D, Ca, inorganic PO4, alk phosphatase, T4, T3Ru, TSH, PTH, BUN, creatinine, TIBC, total protein and 24 hour urine cortisol and creatinine...
  67. ICU ARF DIALYSIS DOSE QUANTIFICATION AND PATIENT OUTCOME
    Emil Paganini; Fiscal Year: 2001
    ..Residual renal function (creatinine clearance or iothalamate clearance) will be measured...