1 ring heterocyclic compounds

Summary

Summary: A class of organic compounds containing a ring structure made up of more than one kind of atom, usually carbon plus another atom. The ring structure can be aromatic or nonaromatic.

Top Publications

  1. ncbi Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals?
    P Antunes
    Division of Radiological Chemistry, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Eur J Nucl Med Mol Imaging 34:982-93. 2007
  2. ncbi Stabilised 111In-labelled DTPA- and DOTA-conjugated neurotensin analogues for imaging and therapy of exocrine pancreatic cancer
    M de Visser
    Department of Nuclear Medicine, Erasmus MC, 3015 GD, Rotterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 30:1134-9. 2003
  3. ncbi Synthesis and radiolabeling of selective high-affinity ligands designed to target non-Hodgkin's lymphoma and leukemia
    Saphon Hok
    Chemistry, Materials and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
    Bioconjug Chem 18:912-21. 2007
  4. ncbi Microwave-supported preparation of (68)Ga bioconjugates with high specific radioactivity
    I Velikyan
    Department of Organic Chemistry, Institute of Chemistry, BMC, Uppsala University, Box 599, SE 751 24 Uppsala, Sweden
    Bioconjug Chem 15:554-60. 2004
  5. ncbi Local targeting of malignant gliomas by the diffusible peptidic vector 1,4,7,10-tetraazacyclododecane-1-glutaric acid-4,7,10-triacetic acid-substance p
    Stefan Kneifel
    Clinic and Institute of Nuclear Medicine, University Hospitals, Basel, Switzerland
    Clin Cancer Res 12:3843-50. 2006
  6. ncbi Radiolabelling DOTA-peptides with 68Ga
    Wouter A P Breeman
    Department of Nuclear Medicine, University Medical Center Rotterdam, Erasmus MC Rotterdam, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 32:478-85. 2005
  7. ncbi 111In-labeled 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid-lys(8)-vasotocin: a new powerful radioligand for oxytocin receptor-expressing tumors
    G Bussolati
    Department of Biomedical Sciences and Human Oncology, University of Torino, Vai Santena 7, 10126 Torino, Italy
    Cancer Res 61:4393-7. 2001
  8. ncbi Detection of nitroaromatic and cyclic nitramine compounds by cyclodextrin assisted capillary electrophoresis quadrupole ion trap mass spectrometry
    Carl A Groom
    Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montreal, Canada PQ H4P 2R2
    J Chromatogr A 1072:73-82. 2005
  9. ncbi Biodegradation of cyclic nitramines by tropical marine sediment bacteria
    Manish Bhatt
    Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montreal, QC H4P 2R2, Canada
    J Ind Microbiol Biotechnol 32:261-7. 2005
  10. ncbi Novel chemically modified analogues of neuropeptide Y for tumor targeting
    Denise Zwanziger
    Institute of Biochemistry, Leipzig University, Bruderstr 34, 04103 Leipzig, Germany
    Bioconjug Chem 19:1430-8. 2008

Research Grants

Detail Information

Publications193 found, 100 shown here

  1. ncbi Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals?
    P Antunes
    Division of Radiological Chemistry, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Eur J Nucl Med Mol Imaging 34:982-93. 2007
    ..In preclinical studies it has shown a striking superiority over its 111In-labelled congener. The purpose of this study was to evaluate whether third-generation somatostatin-based, radiogallium-labelled peptides show the same superiority...
  2. ncbi Stabilised 111In-labelled DTPA- and DOTA-conjugated neurotensin analogues for imaging and therapy of exocrine pancreatic cancer
    M de Visser
    Department of Nuclear Medicine, Erasmus MC, 3015 GD, Rotterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 30:1134-9. 2003
    ....
  3. ncbi Synthesis and radiolabeling of selective high-affinity ligands designed to target non-Hodgkin's lymphoma and leukemia
    Saphon Hok
    Chemistry, Materials and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
    Bioconjug Chem 18:912-21. 2007
    ..Radiolabeling reactions of DOTA-SHALs, with exactly one DOTA entity per targeting SHAL molecule, yielded products with greater than 90% radiochemical purity and specific activities ranging from 97 to 150 muCi/mug...
  4. ncbi Microwave-supported preparation of (68)Ga bioconjugates with high specific radioactivity
    I Velikyan
    Department of Organic Chemistry, Institute of Chemistry, BMC, Uppsala University, Box 599, SE 751 24 Uppsala, Sweden
    Bioconjug Chem 15:554-60. 2004
    ..The first automated prototype using this technology is being tested...
  5. ncbi Local targeting of malignant gliomas by the diffusible peptidic vector 1,4,7,10-tetraazacyclododecane-1-glutaric acid-4,7,10-triacetic acid-substance p
    Stefan Kneifel
    Clinic and Institute of Nuclear Medicine, University Hospitals, Basel, Switzerland
    Clin Cancer Res 12:3843-50. 2006
    ..The complex geometry of rapidly proliferating high-grade gliomas requires a diffusible system targeting tumor-associated surface structures to saturate the tumor, including its margins...
  6. ncbi Radiolabelling DOTA-peptides with 68Ga
    Wouter A P Breeman
    Department of Nuclear Medicine, University Medical Center Rotterdam, Erasmus MC Rotterdam, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 32:478-85. 2005
    ..Here we present the practical aspects and the results of radiolabelling DOTA-peptides with a TiO2-based commercially available 68Ge/68Ga generator...
  7. ncbi 111In-labeled 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid-lys(8)-vasotocin: a new powerful radioligand for oxytocin receptor-expressing tumors
    G Bussolati
    Department of Biomedical Sciences and Human Oncology, University of Torino, Vai Santena 7, 10126 Torino, Italy
    Cancer Res 61:4393-7. 2001
    ..The present study opens new perspectives for imaging and, possibly, therapy of OTR-positive human tumors such as breast and endometrial carcinomas, neuroblastomas, and glioblastomas...
  8. ncbi Detection of nitroaromatic and cyclic nitramine compounds by cyclodextrin assisted capillary electrophoresis quadrupole ion trap mass spectrometry
    Carl A Groom
    Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montreal, Canada PQ H4P 2R2
    J Chromatogr A 1072:73-82. 2005
    ....
  9. ncbi Biodegradation of cyclic nitramines by tropical marine sediment bacteria
    Manish Bhatt
    Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montreal, QC H4P 2R2, Canada
    J Ind Microbiol Biotechnol 32:261-7. 2005
    ..The present findings demonstrate that cyclic nitramine contaminants are likely to be degraded upon release from UXO into tropical marine sediment...
  10. ncbi Novel chemically modified analogues of neuropeptide Y for tumor targeting
    Denise Zwanziger
    Institute of Biochemistry, Leipzig University, Bruderstr 34, 04103 Leipzig, Germany
    Bioconjug Chem 19:1430-8. 2008
    ..In vitro and in vivo studies suggest that receptor-selective analogues of NPY have promising characteristics for future applications in nuclear medicine for breast tumor diagnosis and therapy...
  11. ncbi alpha(v)beta(3) Integrin-targeting radionuclide therapy and imaging with monomeric RGD peptide
    Mitsuyoshi Yoshimoto
    Division of Health Sciences, Graduate School of Medicine, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Japan
    Int J Cancer 123:709-15. 2008
    ..1 MBq). Monomeric RGD peptides, 111In-DOTA-c(RGDfK) and (90)Y-DOTA-c(RGDfK), could be promising tracers for alpha(v)beta(3) integrin-targeting imaging and radiotherapy...
  12. ncbi Military explosives and health: organic energetic compound syndrome?
    Bart Hoek
    Applied Physics Department, Delft University of Technology, The Netherland
    Med Confl Surviv 20:326-33. 2004
    ..This article considers the possible role of OECs, with the intention of encouraging studies to make the role of explosives clear: no cause, a link with insufficient evidence or the cause of many illnesses...
  13. ncbi Improved biodistribution and radioimmunoimaging with poly(ethylene glycol)-DOTA-conjugated anti-CEA diabody
    Lin Li
    Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Bioconjug Chem 17:68-76. 2006
    ....
  14. ncbi Development of tumor targeting bioprobes ((111)In-chimeric L6 monoclonal antibody nanoparticles) for alternating magnetic field cancer therapy
    Sally J DeNardo
    University of California, Davis, Sacramento, California, USA
    Clin Cancer Res 11:7087s-7092s. 2005
    ..Tumor cell radioimmunotargeting of the bioprobes and therapeutic and toxic responses were determined...
  15. ncbi A photoluminescence-based field method for detection of traces of explosives
    E Roland Menzel
    Center for Forensic Studies, Physics Department, Texas Tech University, Lubbock, TX 79409 1051, USA
    ScientificWorldJournal 4:725-35. 2004
    ..We demonstrate the feasibility of CdSe quantum dot sensitization of europium luminescence for time-resolved purposes. This would allow the use of the above 532 nm laser...
  16. ncbi Production and applications of copper-64 radiopharmaceuticals
    Xiankai Sun
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Methods Enzymol 386:237-61. 2004
  17. ncbi Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes
    C Andrew Boswell
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Med Chem 47:1465-74. 2004
    ..These findings further suggest that a bifunctional chelator derivative of CB-TE2A is a highly desirable alternative for labeling copper radionuclides to biological molecules for diagnostic imaging and targeted radiotherapy...
  18. ncbi Enhancing the attenuation of explosives in surface soils at military facilities: combined sorption and biodegradation
    Mark E Fuller
    Shaw Environmental and Infrastructure, Princeton Research Center, 4100 Quakerbridge Road, Lawrenceville, New Jersey 08648, USA
    Environ Toxicol Chem 23:313-24. 2004
    ..These results indicate that the application of inexpensive adsorbents and cosubstrates to soils may significantly improve the protection of groundwater resources underlying live fire ranges...
  19. ncbi Enhancing the attenuation of explosives in surface soils at military facilities: sorption-desorption isotherms
    Paul B Hatzinger
    Shaw Environmental and Infrastructure, Princeton Research Center, 4100 Quakerbridge Road, Lawrenceville, New Jersey 08648, USA
    Environ Toxicol Chem 23:306-12. 2004
    ..The data indicate that the application of specific adsorbents to soils at military impact ranges may significantly improve the protection of local groundwater resources...
  20. ncbi Green explosives: collateral damage
    Jim Giles
    Nature 427:580-1. 2004
  21. ncbi A case study of contaminants on military ranges: Camp Edwards, Massachusetts, USA
    Jay Clausen
    AMEC Earth and Environmental, 239 Littleton Road, Suite 1B, Westford MA 01886, USA
    Environ Pollut 129:13-21. 2004
    ..The recommendations in this report are based on data obtained for more than 200 analytes from more than 15,000 environmental samples...
  22. ncbi Effect of iron(III), humic acids and anthraquinone-2,6-disulfonate on biodegradation of cyclic nitramines by Clostridium sp. EDB2
    B Bhushan
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada
    J Appl Microbiol 100:555-63. 2006
    ..To determine the biodegradation of cyclic nitramines by an anaerobic marine bacterium, Clostridium sp. EDB2, in the presence of Fe(III), humic acids (HA) and anthraquinone-2,6-disulfonate (AQDS)...
  23. ncbi Radiolanthanide-labeled monoclonal antibody CC49 for radioimmunotherapy of cancer: biological comparison of DOTA conjugates and 149Pm, 166Ho, and 177Lu
    Huma Mohsin
    Department of Chemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Bioconjug Chem 17:485-92. 2006
    ..When labeled with 149Pm, 166Ho, and 177Lu, MeO-DOTA-CC49 has potential for RIT of colorectal cancer and other carcinomas...
  24. ncbi Leaching of contaminated leaves following uptake and phytoremediation of RDX, HMX, and TNT by poplar
    Jong Moon Yoon
    Department of Civil and Environmental Engineering, The University of Iowa, Iowa City, Iowa 52242, USA
    Int J Phytoremediation 8:81-94. 2006
    ..Such behavior for HMX was reported earlier and is reconfirmed here. All three compounds differ substantially in their fate and transport during the leaching process...
  25. ncbi Bioaccumulation of explosive compounds in the marine mussel, Mytilus galloprovincialis
    Gunther Rosen
    Space and Naval Warfare Systems Center, Environmental Sciences and Applied Systems Branch, 53475 Strothe Road, Code 2375, San Diego, CA 92152, USA
    Ecotoxicol Environ Saf 68:237-45. 2007
    ..15-0.49h). It is unlikely, based on these data, that exposure conditions for these explosive compounds in the marine environment pose unacceptable risks to mussels, and it appears that potential for trophic transfer is quite low...
  26. ncbi In vivo evaluation and small-animal PET/CT of a prostate cancer mouse model using 64Cu bombesin analogs: side-by-side comparison of the CB-TE2A and DOTA chelation systems
    Jered C Garrison
    Harry S Truman Memorial VA Hospital, Columbia, Missouri 65201 5275, USA
    J Nucl Med 48:1327-37. 2007
    ..The study directly compares 64Cu bombesin analogs using the CB-TE2A and DOTA chelation systems in a prostate cancer xenograft SCID (severely compromised immunodeficient) mouse model...
  27. ncbi Evaluation of CD20, CD22, and HLA-DR targeting for radioimmunotherapy of B-cell lymphomas
    John M Pagel
    Fred Hutchinson Cancer Research Center, University of Washington, and Aletheon Pharmaceuticals, Inc, Seattle, Washington 98109, USA
    Cancer Res 67:5921-8. 2007
    ..Improvements in tumor-to-normal organ ratios of radioactivity cannot be achieved using directly labeled Abs in combination but may be afforded by novel pretargeting methods...
  28. ncbi Toxicity of explosive compounds to the marine mussel, Mytilus galloprovincialis, in aqueous exposures
    Gunther Rosen
    Space and Naval Warfare Systems Center, Environmental Sciences and Applied Systems Branch, 53475 Strothe Road, San Diego, CA 92152, USA
    Ecotoxicol Environ Saf 68:228-36. 2007
    ..6 and 0.92microg g(-1) (86 and 3.1nmolg(-1)) ww were not associated with any toxicity for RDX and HMX, respectively...
  29. ncbi Influence of chelate conjugation on a newly identified tumor-targeting peptide
    Walter Mier
    Department of Nuclear Medicine, University of Heidelberg, Heidelberg, Germany
    J Nucl Med 48:1545-52. 2007
    ..This study investigated whether coupling of a new peptide, FROP-1, to the chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) resulted in structural restriction and, consequently, improved binding and stability...
  30. ncbi Conjugation of DOTA-like chelating agents to peptides and radiolabeling with trivalent metallic isotopes
    Jane K Sosabowski
    Nuclear Medicine Research Laboratory, St Bartholomew s Hospital, London, EC1A 7BE, UK
    Nat Protoc 1:972-6. 2006
    ..The product can be radiolabeled by addition of a suitable metal salt, followed, if necessary, by removal of the unchelated metal. The entire process of conjugation, purification and radiolabeling should take approximately 12.5 h...
  31. ncbi Explosives: fate, dynamics, and ecological impact in terrestrial and marine environments
    Albert L Juhasz
    Centre for Environmental Risk Assessment and Remediation, University of South Australia, Mawson Lakes Campus, Adelaide, Australia, 5095
    Rev Environ Contam Toxicol 191:163-215. 2007
    ....
  32. pmc Rational design and generation of a bimodal bifunctional ligand for antibody-targeted radiation cancer therapy
    Hyun Soon Chong
    Chemistry Division, Biological, Chemical, and Physical Sciences Department, Illinois Institute of Technology, Chicago, Illinois 60616, USA
    J Med Chem 51:118-25. 2008
    ..C-NETA rapidly binds both Lu(III) and Bi(III), and the respective metal complexes remain extremely stable in serum for 14 days. (177)Lu -C-NETA and (205/6)Bi -C-NETA possess an excellent or acceptable in vivo biodistribution profile...
  33. ncbi Halide salts accelerate degradation of high explosives by zerovalent iron
    Jong Sung Kim
    Center for Environmental Toxicology and School of Natural Resources, University of Nebraska Lincoln, 362 Plant Sciences, Lincoln, NE 68583, USA
    Environ Pollut 147:634-41. 2007
    ..HMX was most difficult to remove using ZVI alone but ZVI remained effective after five HMX reseeding cycles when Br(-) was present in solution...
  34. ncbi Radioiodinated versus radiometal-labeled anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments: optimal pharmacokinetics for therapy
    Vania Kenanova
    Division of Molecular Biology, Beckman Research Institute of the City of Hope, Department of Radioimmunotherapy, Duarte, CA, USA
    Cancer Res 67:718-26. 2007
    ..Finally, the 125I/111In biodistribution data allowed for dose estimations, which suggest the 131I-labeled scFv-Fc H310A/H435Q as a promising candidate for radioimmunotherapy...
  35. ncbi Effects of linker variation on the in vitro and in vivo characteristics of an 111In-labeled RGD peptide
    Ingrid Dijkgraaf
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, PO Box 9101, HB Nijmegen 6500, The Netherlands
    Nucl Med Biol 34:29-35. 2007
    ....
  36. ncbi Degradation of explosives-related compounds using nickel catalysts
    Mark E Fuller
    Shaw Environmental, Inc, 17 Princess Road, Lawrenceville, NJ 08648, USA
    Chemosphere 67:419-27. 2007
    ..These data indicate that nickel-based catalysts may be an effective means for remediation of energetics-contaminated groundwater...
  37. ncbi Radiolabelling of glucose-Tyr3-octreotate with 125I and analysis of its metabolism in rats: comparison with radiolabelled DOTA-Tyr3-octreotate
    Milos Petrik
    Department of Biophysics and Physical Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
    Anticancer Res 27:3941-6. 2007
    ..The radiochemical purity of radiolabelled peptides and the analyses of rat urine were determined by HPLC and/or ITLC-SG methods. Male Wistar rats were used in the elimination studies...
  38. ncbi Structure-activity relationships of 111In- and 99mTc-labeled quinolin-4-one peptidomimetics as ligands for the vitronectin receptor: potential tumor imaging agents
    Thomas D Harris
    Discovery Research, Bristol Myers Squibb Medical Imaging, 331 Treble Cove Road, N Billerica, Massachusetts 01862, USA
    Bioconjug Chem 17:1294-313. 2006
    ..A scintigraphic imaging study with (111)In-TA138 showed a clear delineation of the tumors and rapid clearance of activity from nontarget tissues...
  39. ncbi Tumor targeting with antibody-functionalized, radiolabeled carbon nanotubes
    Michael R McDevitt
    Molecular Pharmacology and Chemistry Department, Departments of Medicine and Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Nucl Med 48:1180-9. 2007
    ..We hypothesized that novel prototype nanostructures consisting of biologics, radionuclides, fluorochromes, and CNT could be synthesized and designed to target tumor cells...
  40. ncbi Dimeric DOTA-alpha-melanocyte-stimulating hormone analogs: synthesis and in vivo characteristics of radiopeptides with high in vitro activity
    Jean Philippe Bapst
    Laboratory of Endocrinology, Department of Research, University Hospital and University Children s Hospital, Basel, Switzerland
    J Recept Signal Transduct Res 27:383-409. 2007
    ..In conclusion, although radiolabeled alpha-MSH dimer peptides display excellent receptor affinity and internalization, they are no alternative to the monomeric DOTA-NAPamide for in vivo application...
  41. ncbi Carbon nanotubes: potential benefits and risks of nanotechnology in nuclear medicine
    Raymond M Reilly
    University of Toronto, Toronto, Ontario, Canada
    J Nucl Med 48:1039-42. 2007
  42. ncbi Optimization of the separation of organic explosives by capillary electrophoresis with artificial neural networks
    Sonia Casamento
    Centre for Forensic Science, Department of Chemistry, Materials and Forensic Science University of Technology, Sydney PO Box 123, Broadway, NSW, Australia, 2007
    J Forensic Sci 48:1075-83. 2003
    ..This provided a more efficient separation without compromising detection sensitivity...
  43. ncbi Synthesis and evaluation of novel bifunctional chelating agents based on 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid for radiolabeling proteins
    L L Chappell
    Radioimmune and Inorganic Chemistry Section, National Cancer Institute NIH, Bethesda, MD 20892 1002, USA
    Nucl Med Biol 30:581-95. 2003
    ..The 1B4M-DOTAmay have potential for radioimmunotherapy applications...
  44. ncbi Modification of the structure of a metallopeptide: synthesis and biological evaluation of (111)In-labeled DOTA-conjugated rhenium-cyclized alpha-MSH analogues
    Zhen Cheng
    Department of Chemistry, 125 Chemistry Building, University of Missouri Columbia, Columbia, MO 65211, USA
    J Med Chem 45:3048-56. 2002
    ..13 +/- 1.47% ID/g for (111)In-10 at 4 h pi. Complex 6 showed high melanoma uptake and lower kidney uptake than the corresponding Lys(11) analogues, supporting 6 for further investigations as a potential therapeutic radiopharmaceutical...
  45. ncbi Stimulating the anaerobic biodegradation of explosives by the addition of hydrogen or electron donors that produce hydrogen
    Neal R Adrian
    Army Corps of Engineers, Engineer Research and Development Center, PO Box 9005, Champaign, IL 61821 9005, USA
    Water Res 37:3499-507. 2003
    ..Our findings suggest that the addition of H2 or electron donors that produce H2 may be a useful strategy for enhancing the anaerobic biodegradation of explosives in contaminated groundwater and soils...
  46. ncbi Synthesis and evaluation of a monoreactive DOTA derivative for indium-111-based residualizing label to estimate protein pharmacokinetics
    Takahiro Mukai
    Department of Nuclear Medicine and Diagnostic Imaging, Graduate School of Medicine, Kyoto University, Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Pharm Pharmacol 54:1073-81. 2002
    ..These findings also suggested that the introduction of a protein binding site at a position distal from the unmodified DOTA structure would be preferable to preparing 111In-DOTA-labelled proteins with higher specific activity...
  47. ncbi Fluorescence quenching as an indirect detection method for nitrated explosives
    J V Goodpaster
    Department of Chemistry, Michigan State University, East Lansing 48824-1322, USA
    Anal Chem 73:2004-11. 2001
    ..The indirect fluorescence quenching method shows increased sensitivity and selectivity over traditional UV-visible absorbance as well as the ability to detect a wider range of organic and inorganic nitrated compounds...
  48. ncbi Vinyl sulfone bifunctional derivatives of DOTA allow sulfhydryl- or amino-directed coupling to antibodies. Conjugates retain immunoreactivity and have similar biodistributions
    Lin Li
    Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Bioconjug Chem 13:110-5. 2002
    ..These novel BCAs are easy to synthesize, offer versatile conjugation options, and give equivalent biodistributions that result in high tumor uptake and good tumor-to-blood ratios...
  49. ncbi Chelators for radioimmunotherapy: I. NMR and ab initio calculation studies on 1,4,7,10-tetra(carboxyethyl)-1,4,7,10-tetraazacyclododecane (DO4Pr) and 1,4,7-tris(carboxymethyl)-10-(carboxyethyl)-1,4,7,10-tetraazacyclododecane (DO3A1Pr)
    D A Keire
    Materials and Process Simulation Center, Beckman Institute (139-74, California Institute of Technology, Pasadena, California 91125, USA
    Inorg Chem 40:4310-8. 2001
    ..The new calculations predict an improvement in the rate of metal loading that more closely matches the experimentally observed change in the rate...
  50. ncbi Studies on plant-mediated fate of the explosives RDX and HMX
    R Bhadra
    Department of Bioengineering, Rice University, Houston, TX 77005-1892, USA
    Chemosphere 44:1259-64. 2001
    ..The intracellular 14C-label in these RDX studies was detected in two forms: intact RDX and bound unknown(s)...
  51. ncbi Dissolution rates of three high explosive compounds: TNT, RDX, and HMX
    Jason C Lynch
    Department of Environmental Engineering Sciences, University of Florida, Gainesville 32611 6450, USA
    Chemosphere 47:725-34. 2002
    ..Dissolution rate correlation equations were developed for each explosive compound incorporating the three aforementioned variables, independently, and collectively in one correlation equation...
  52. ncbi The addition of DTPA to [177Lu-DOTA0,Tyr3]octreotate prior to administration reduces rat skeleton uptake of radioactivity
    Wouter A P Breeman
    Department of Nuclear Medicine, Erasmus University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 30:312-5. 2003
    ..After labelling [DOTA(0),Tyr(3)]octreotate with (177)Lu the addition of DTPA prior to intravenous administration of [(177)Lu-DOTA(0),Tyr(3)]octreotate is strongly recommended...
  53. ncbi Photocatalytic degradation of explosives contaminated water
    S J Lee
    Department of Environmental Health, Graduate School of Public Health, Seoul National University, 28 Yeungeon Dong, Chongno Gu, Seoul, 110 799, Korea
    Water Sci Technol 46:139-45. 2002
    ..Nitrate, nitrite, and ammonium ions were detected as the nitrogen byproducts from the photocatalysis, and more than 50% of the total nitrogen was recovered as nitrate ion in every explosives...
  54. ncbi Metabolism and renal clearance of 111In-labeled DOTA-conjugated antibody fragments
    S W Tsai
    Division of Immunology, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, California 91010, USA
    Bioconjug Chem 12:264-70. 2001
    ..66. In that example, we found that the major radioactive species was also [111In]DOTA-epsilon-amino-lysine...
  55. pmc Biodegradation of nitro-substituted explosives 2,4,6-trinitrotoluene, hexahydro-1,3,5-trinitro-1,3,5-triazine, and octahydro-1,3,5,7-tetranitro-1,3,5-tetrazocine by a phytosymbiotic Methylobacterium sp. associated with poplar tissues (Populus deltoides x
    Benoit Van Aken
    Department of Civil and Environmental Engineering, The University of Iowa, Iowa City, Iowa 52242, USA
    Appl Environ Microbiol 70:508-17. 2004
    ..strain BJ001 may be involved in natural attenuation or in situ biodegradation (including phytoremediation) of explosive-contaminated sites...
  56. ncbi Comparison of yttrium and indium complexes of DOTA-BA and DOTA-MBA: models for (90)Y- and (111)In-labeled DOTA-biomolecule conjugates
    Shuang Liu
    Bristol Myers Squibb Medical Imaging, 331 Treble Cove Road, North Billerica, Massachusetts 01862, USA
    Bioconjug Chem 13:902-13. 2002
    ..The fluxionality of these complexes is due to rapid rotation of acetate/acetamide chelating arms and inversion of ethylenic groups of the macrocyclic ring...
  57. pmc Improved radiotracing of oxytocin receptor-expressing tumours using the new [111In]-DOTA-Lys8-deamino-vasotocin analogue
    B Chini
    CNR Institute of Neuroscience, Cellular and Molecular Pharmacology Section, Via Vanvitelli 32, 20129 Milano, Italy
    Br J Cancer 89:930-6. 2003
    ..These features makes radiolabelled DOTA-dLVT a very good candidate for the radiotargeting of OTR-expressing tumours...
  58. ncbi Detection of explosives and their degradation products in soil environments
    A Halasz
    Biotechnology Research Institute, National Research Council Canada, Montreal, Quebec
    J Chromatogr A 963:411-8. 2002
    ..Modifiers such as MeCN and water enhanced the SC-CO2 extractability of HMX from plant tissues...
  59. ncbi Imaging of urokinase-type plasminogen activator receptor expression using a 64Cu-labeled linear peptide antagonist by microPET
    Zi Bo Li
    Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305 5484, USA
    Clin Cancer Res 14:4758-66. 2008
    ..Noninvasive imaging of this receptor in vivo with radiolabeled peptides that specifically target uPAR may therefore be useful to decipher the potential invasiveness of malignant lesions...
  60. ncbi The synthesis and chelation chemistry of DOTA-peptide conjugates
    Luis M De León-Rodríguez
    University of Texas Southwestern Medical Center, Advanced Imaging Research Center, 2201 Inwood Road NE 4 2, Dallas, Texas 75390 8568, USA
    Bioconjug Chem 19:391-402. 2008
    ....
  61. ncbi Portable remote Raman system for monitoring hydrocarbon, gas hydrates and explosives in the environment
    Shiv K Sharma
    Hawaii Institute of Geophysics and Planetology, University of Hawaii, Honolulu, HI 96822, USA
    Spectrochim Acta A Mol Biomol Spectrosc 61:2404-12. 2005
    ....
  62. ncbi Activity of selected neonicotinoids and dicrotophos on nontarget arthropods in cotton: implications in insect management
    A L Kilpatrick
    Department of Entomology, Edisto Research and Education Center, Clemson University, Blackville, SC 29817, USA
    J Econ Entomol 98:814-20. 2005
    ..Results demonstrated that neonicotinoids differ in activity against predaceous arthropods and bollworm eggs and that high predator mortality can result in resurgence of bollworm larvae and additional insecticide costs...
  63. ncbi Anion template effect on the self-assembly and interconversion of metallacyclophanes
    Cristian Saul Campos-Fernández
    Department of Chemistry, Texas A and M University, College Station, Texas 77842, USA
    J Am Chem Soc 127:12909-23. 2005
    ..The formation of the various metallacyclophanes is discussed in light of the factors that influence these self-assembly reactions, such as choice of metal ion, anion, and solvent...
  64. ncbi Stereoselective synthesis of microcarpalide
    Juan Murga
    U P de Química Inorgánica y Orgánica, Universidad Jaume I, Castellon, E 12080 Castellón, Spain
    Org Lett 4:3447-9. 2002
    ..structure: see text]..
  65. ncbi Degradation kinetics and mechanism of RDX and HMX in TiO2 photocatalysis
    J K Choi
    Institute of Health and Environment, School of Public Health, Seoul National University, Seoul 110 799, Republic of Korea
    Environ Technol 27:219-32. 2006
    ..The total nitrogen recovery was about 60% from RDX (20 mg l(-1)), and 70% from HMX (5 mg l(-1)), respectively. Finally, a mechanism for RDX/HMX photocatalysis was proposed, along with supporting qualitative and quantitative evidence...
  66. ncbi A comparison of the Low Mode and Monte Carlo conformational search methods
    Carol Parish
    Department of Chemistry, Hobart College, Geneva, NY 14456, USA
    J Mol Graph Model 21:129-50. 2002
    ....
  67. ncbi Current and potential therapeutic uses of lanthanide radioisotopes
    C S Cutler
    University of Missouri Research Reactor, Research Park Drive, Columbia, MO 65211, USA
    Cancer Biother Radiopharm 15:531-45. 2000
    ....
  68. ncbi Biological denitrification of hydrolysates from octahydro-1,3,5,7 tetranitro-1,3,5,7-tetrazocine
    Kimberly L Ogden
    Department of Chemical and Environmental Engineering, University of Arizona, Tucson 85721, USA
    Water Environ Res 74:338-45. 2002
    ..This work demonstrates the feasibility of using Hyphomicrobiun sp. bacteria to treat HMX hydrolysate and presents a model that can be used to design a large-scale system...
  69. ncbi Toxicity of the explosives 2,4,6-trinitrotoluene, hexahydro-1,3,5-trinitro-1,3,5-triazine, and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine in sediments to Chironomus tentans and Hyalella azteca: low-dose hormesis and high-dose mortality
    Jeffery A Steevens
    US Army Corps of Engineers, Engineer Research and Development Center, CEERD EP R, Vicksburg, Misissippi 39180, USA
    Environ Toxicol Chem 21:1475-82. 2002
    ....
  70. ncbi Anaerobic biotransformation of explosives in aquifer slurries amended with ethanol and propylene glycol
    Neal R Adrian
    Engineering Research and Development Center, Army Corps of Engineers, Construction Engineering Research Laboratory, P O Box 9005, Champaign, IL 61821 9005, USA
    Chemosphere 66:1849-56. 2007
    ..Our findings indicate the addition of ethanol and propylene to the aquifer slurries increased the hydrogen concentrations and enhanced the biotransformation of RDX and HMX in the explosive-contaminated soil...
  71. ncbi Anti-HLA-DR/anti-DOTA diabody construction in a modular gene design platform: bispecific antibodies for pretargeted radioimmunotherapy
    D G DeNardo
    Department of Internal Medicine, Section of Radiodiagnosis and Therapy, University of California Davis Medical Center, 1508 Alhambra Blvd, Suite 3100, Sacramento, CA 95816, USA
    Cancer Biother Radiopharm 16:525-35. 2001
    ..Diabodies from various scFv can easily be produced, thereby facilitating comparative preclinical studies en route to development of new tumor targeting molecules...
  72. ncbi Renal and systemic pH imaging by contrast-enhanced MRI
    Natarajan Raghunand
    Cancer Center Division, University of Arizona Health Sciences Center, Tucson, Arizona 85724 5024, USA
    Magn Reson Med 49:249-57. 2003
    ..Pretreatment of mice with the carbonic anhydrase inhibitor acetazolamide resulted in systemic metabolic acidosis and accompanying urine alkalinization that was readily detected by this dual-contrast-agent approach...
  73. ncbi Biodistribution of 111In- and 90Y-labeled DOTA and maleimidocysteineamido-DOTA conjugated to chimeric anticarcinoembryonic antigen antibody in xenograft-bearing nude mice: comparison of stable and chemically labile linker systems
    L E Williams
    Division of Diagnostic Radiology, City of Hope National Medical Center, Duarte, California 91010, USA
    Bioconjug Chem 9:87-93. 1998
    ..Alternatively, if bone marrow radiation dose is dominated by circulating antibody, the chemically labile linker system employed by the MC-DOTA conjugate offers the advantage of enhanced blood clearance...
  74. ncbi Synthesis, characterization, and X-ray crystal structure of In(DOTA-AA) (AA = p-aminoanilide): a model for 111In-labeled DOTA-biomolecule conjugates
    Shuang Liu
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, USA
    Inorg Chem 42:8831-7. 2003
    ..Although Y(3+) and In(3+) complexes of DOTA-monoamide are both eight-coordinate in the solid state, the difference in their solution structures is most likely responsible for their difference in lipophilicity...
  75. ncbi Inhibition of enzymatic degradation of adhesive-dentin interfaces
    J De Munck
    Leuven BIOMAT Research Cluster, Department of Conservative Dentistry, School of Dentistry, Oral Pathology and Maxillo Facial Surgery, Catholic University of Leuven, Kapucijnenvoer 7, 3000 Leuven, Belgium
    J Dent Res 88:1101-6. 2009
    ..Water sorption of adhesive interfaces most likely remains the principal mechanism of bond degradation, while endogenous enzymes appear to contribute to bond degradation of only etch & rinse adhesives...
  76. pmc Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160)
    Marcel Kaiser
    Swiss Tropical Institute, Basel, Switzerland
    Antimicrob Agents Chemother 51:2991-3. 2007
    ..In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis...
  77. ncbi Indium-labeled macrocyclic conjugates of naltrindole: high-affinity radioligands for in vivo studies of peripheral delta opioid receptors
    Romain A Duval
    Departments of Radiology and the Radiopharmaceutical Sciences Institute, and Medical Pharmacology and Physiology, University of Missouri Columbia, Columbia, Missouri 65212, USA
    J Med Chem 50:2144-56. 2007
    ..Uptakes of radioactivity are saturable by the non-radioactive complexes, inhibited by naltrexone, and blocked by NTI. Thus, these radiometal-labeled NTI analogues warrant further study by single-photon emission computed tomography...
  78. ncbi In vitro and in vivo evaluation of 64Cu-labeled DOTA-linker-bombesin(7-14) analogues containing different amino acid linker moieties
    Jesse J Parry
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Bioconjug Chem 18:1110-7. 2007
    ..Overall, this study shows that BN analogues containing amino acid linkers can be used for the PET imaging of GRPR-expressing prostate cancer and that these linkers lead to lower background tissue uptake...
  79. ncbi CuI/4-hydro-L-proline as a more effective catalytic system for coupling of aryl bromides with N-boc hydrazine and aqueous ammonia
    Liqin Jiang
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    J Org Chem 74:4542-6. 2009
    ..These processes allow assembly of N-aryl hydrazides and primary arylamines that bear a wide range of functional groups including hydroxyl, amine, trifluoromethyl, ester, nitro, and ketone...
  80. ncbi Conformational analysis of N,N-disubstituted-1,4-diazepane orexin receptor antagonists and implications for receptor binding
    Christopher D Cox
    Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
    Bioorg Med Chem Lett 19:2997-3001. 2009
    ..Synthesis and evaluation of a macrocycle that enforces a similar conformation suggest that this geometry mimics the bioactive conformation...
  81. ncbi Heterocycle-based MMP inhibitors with P2' substituents
    S Pikul
    Procter and Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA
    Bioorg Med Chem Lett 11:1009-13. 2001
    ..An X-ray structure of a stromelysin inhibitor complex was obtained to provide insights into the SAR and selectivity trends observed for the series...
  82. ncbi The first synthesis of substituted azepanes mimicking monosaccharides: a new class of potent glycosidase inhibitors
    Hongqing Li
    Ecole Normale Superieure, Departement de Chimie, UMR 8642, 24 rue Lhomond, 75231 Paris 05, France
    Org Biomol Chem 2:1492-9. 2004
    ..2 muM) despite a D-gluco relative configuration...
  83. ncbi Stereoselective synthesis of 2,5-disubstituted-1,4-oxathiane S-oxides
    Simon T Bedford
    Department of Chemistry, King s College London, Strand, London WC2R 2LS, UK
    Org Biomol Chem 3:404-6. 2005
    ..Beta-allyloxy and beta-propargyloxy tert-butyl sulfoxides undergo tandem sulfoxide eliminination-intramolecular sulfenic acid addition reactions to produce 1,4-oxathiane S-oxides...
  84. ncbi Trace explosive detection in aqueous samples by solid-phase extraction ion mobility spectrometry (SPE-IMS)
    Tricia L Buxton
    Ohio University, Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Clippinger Laboratories, Athens, Ohio 45701 2979, USA
    Appl Spectrosc 57:223-32. 2003
    ..SIMPLISMA (SIMPLe-to-use-Interactive Self-modeling Mixture Analysis) was applied to the data to resolve features that vary with respect to time...
  85. ncbi Total synthesis of the putative structure of stemonidine: the definitive proof of misassignment
    Francisco Sánchez-Izquierdo
    Universitat Autonoma de Barcelona, Departament de Quimica, 08193 Bellaterra, Spain
    Org Lett 9:1769-72. 2007
    ..The NMR data of the synthetic material do not match those reported for the natural product. It is concluded that the structure assigned to stemonidine is incorrect, and it must be reassigned as stemospironine...
  86. ncbi Evaluation of bioremediation methods for the treatment of soil contaminated with explosives in Louisiana Army Ammunition Plant, Minden, Louisiana
    Brandon Clark
    Department of Biological Sciences, Nicholls State University, Thibodaux, LA 70310, USA
    J Hazard Mater 143:643-8. 2007
    ..Both methods maintained high bacterial population fairly well. The results of this bench-scale study are promising with regard to transferring the technology to full-scale application at this site...
  87. ncbi Dual-function probe for PET and near-infrared fluorescence imaging of tumor vasculature
    Weibo Cai
    Molecular Imaging Program at Stanford MIPS, Department of Radiology, and Bio X Program, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    J Nucl Med 48:1862-70. 2007
    ..The development of a dual-function PET/near-infrared fluorescence (NIRF) probe can allow for accurate assessment of the pharmacokinetics and tumor-targeting efficacy of QDs...
  88. ncbi New insight into the reaction of singlet oxygen with sulfur-containing cyclic alkenes: dye-sensitized photooxygenation of 5,6-dihydro-1,4-dithiins
    Flavio Cermola
    Dipartimento di Chimica Organica e Biochimica, Universita degli Studi di Napoli Federico II, Complesso Universitario Monte Sant Angelo, Via Cinthia, I 80126, Napoli, Italy
    J Org Chem 72:10075-80. 2007
    ..S-Oxidation of dithiins is insignificant, except for the monosubstituted amide derivative or in the presence of protic species, and occurs selectively at the S-1 atom...
  89. ncbi Formation of macrocycles via ring-closing olefin metathesis
    C W Lee
    Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    J Org Chem 66:7155-8. 2001
    ..The dimerization appears to be under thermodynamic control with the product mixture dependent not only on the electronic and steric nature of the substrate but also on concentration...
  90. ncbi Studies on the biodistribution of dextrin nanoparticles
    C Goncalves
    IBB Institute for Biotechnology and Bioengineering, Centre for Biological Engineering, Minho University, Campus de Gualtar, 4710 057 Braga, Portugal
    Nanotechnology 21:295103. 2010
    ..The effect of PEG surface coating on the blood clearance rate and organ biodistribution of the nanoparticles was also studied...
  91. ncbi Efficient cycloreversion of cis,syn-thymine photodimer by a Zn2+ -1,4,7,10-tetraazacyclododecane complex bearing a lumiflavin and tryptophan by chemical reduction and photoreduction of a lumiflavin unit
    Yasuyuki Yamada
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, 278 8510, Japan
    J Biol Inorg Chem 11:1007-23. 2006
    ..Comparison of the photochemical properties of ZnL3 with those of ZnL4 suggested that a tryptophan unit in ZnL3 contributed to the stabilities of the flavin through intramolecular photoinduced electron transfer...
  92. ncbi Halogenated metabolites from the new Okinawan red alga Laurencia yonaguniensis
    Yoshinori Takahashi
    Division of Material Science, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060 0810, Japan
    J Nat Prod 65:395-8. 2002
    ..Neoirietetraol (1) was toxic to the brine shrimp (Altemia salina; LC50, 40.1 microM) and also showed weak antibacterial activities against two marine bacteria, Alcaligenes aquamarinus and Escherichia coli...
  93. ncbi Surface treatment agent for dental metals using a thiirane monomer and a phosphoric acid monomer
    Yoshinori Kadoma
    Department of Applied Functional Molecules, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Japan
    Dent Mater J 21:156-69. 2002
    ..The combined treatment of EP3MA-MDP or EP8MA-MDP was used effectively for non-precious metals as well as precious metals, and was shown to be extremely effective compared with the single treatment of EP3MA, EP8MA, or MDP...
  94. ncbi A comparative study of 131I and 177Lu labeled somatostatin analogues for therapy of neuroendocrine tumours
    E B de Araujo
    Radiopharmacy Directory, Nuclear and Energetic Research Institute IPEN, Av Lineu Prestes, 2242, Cidade Universitaria, Butanta, CEP 05508 000, Sao Paulo, Brazil
    Appl Radiat Isot 67:227-33. 2009
    ..In addition, (131)I-DOTATATE showed significative tumour uptake, despite not so persistent after 24h. (131)I-DOTATATE can represent a cost-effective alternative to lutetium labeled peptide for neuroendocrine tumours therapy...
  95. ncbi Modified titania nanotubes for decontamination of sulphur mustard
    G K Prasad
    Defense Research and Development Establishment, Jhansi Road, Gwalior, India
    J Hazard Mater 167:1192-7. 2009
    ..Thiodiglycol, 1,4-oxathiane were observed to be major products formed except on Ru(3+)-titania nanotubes. Sulphur mustard sulphoxide formed on Ru(3+)-titania nanotubes indicating oxidative decontamination of HD...
  96. ncbi A quinazoline-derivative DOTA-type gallium(III) complex for targeting epidermal growth factor receptors: synthesis, characterisation and biological studies
    Raquel Garcia
    Unidade de Ciências Químicas e Radiofarmacêuticas, Instituto Tecnologico e Nuclear, Estrada Nacional 10, Apartado 21, 2686 953, Sacavem, Portugal
    J Biol Inorg Chem 14:261-71. 2009
    ....
  97. pmc 68Ga-labelled exendin-3, a new agent for the detection of insulinomas with PET
    Maarten Brom
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Eur J Nucl Med Mol Imaging 37:1345-55. 2010
    ..Glucagon-like peptide 1 (GLP-1), the natural ligand of GLP-1R, is rapidly degraded in vivo. A more stable agonist of GLP-1R is exendin-3. We investigated imaging of insulinomas with DOTA-conjugated exendin-3 labelled with (68)Ga...
  98. ncbi Development of positron emission tomography imaging by 64Cu-labeled Fab for detecting ERC/mesothelin in a mesothelioma mouse model
    Chisato Yoshida
    Diagnostic Imaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Anagawa, Inage Ku, Japan
    Nucl Med Commun 31:380-8. 2010
    ..We evaluated the affinity of radiolabeled monoclonal antibodies to the C-terminal fragment of ERC/mesothelin for this purpose...
  99. ncbi Enhanced therapeutic index of radioimmunotherapy (RIT) in prostate cancer patients: comparison of radiation dosimetry for 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA)-peptide versus 2IT-DOTA monoclonal antibody linkage for RIT
    Sally J DeNardo
    University of California Davis School of Medicine, Sacramento, California 95816, USA
    Clin Cancer Res 9:3938S-44S. 2003
    ....
  100. ncbi Reductive transformation of hexahydro-1,3,5-trinitro-1,3,5-triazine, octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine, and methylenedinitramine with elemental iron
    Seok Young Oh
    tDepartment of Civil and Environmental Engineering, University of Delaware, Newark, Delaware 19716, USA
    Environ Toxicol Chem 24:2812-9. 2005
    ..Our results show that in a cast iron-water system, RDX may be transformed via multiple mechanisms involving different reaction paths and reaction sites...
  101. pmc DNA-templated organic synthesis and selection of a library of macrocycles
    Zev J Gartner
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Science 305:1601-5. 2004
    ..This work represents the translation, selection, and amplification of libraries of nucleic acids encoding synthetic small molecules rather than biological macromolecules...

Research Grants17

  1. New Ligands for Radioimmunotherapy and MRI of Cancer
    Hyun Soon Chong; Fiscal Year: 2006
    ..The results of the proposed research will contribute to the development of better drugs for both MRI and RIT, which will greatly enhance clinical exploration of both modalities, and directly benefit cancer patients. ..
  2. Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancer
    Shaker Mousa; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  3. LCDIO FOR LYMPH NODE MR IMAGING
    Ralph Weissleder; Fiscal Year: 2001
    ..abstract_text> ..
  4. Production of High Specific Activity Lutetium-177
    Cathy Cutler; Fiscal Year: 2005
    ..If impurities are present, develop methods to prevent their introduction or to remove them from the final product. Perform radiolabelling of the Lu-177 produced to molecules of interest in therapeutic applications. ..
  5. MR IMAGING OF GENE EXPRESSION
    Ralph Weissleder; Fiscal Year: 2004
    ..The long-term goal of this research is to extend the capabilities of MR and apply it to in vivo imaging of gene expression. ..
  6. HIGH EFFICIENCY LYMPHOCYTE LABELING FOR IN VIVO TRACKING
    Ralph Weissleder; Fiscal Year: 2004
    ..Furthermore, the investigators believe that the proposed research is in the widest interest to the current NIAID program and other research programs in further developing robust tools to track immune cells in vivo. ..
  7. SYNTHESIS OF NOVEL BIOLOGICALLY ACTIVE NATURAL PRODUCTS
    ROBERT BOECKMAN; Fiscal Year: 2002
    ..The hypothesis that an internal chelate of suitably disposed oxygen functions permits the modification of the ring conformation from half-chair to half-boat will be tested. ..
  8. MR imaging of myeloperoxidase activity
    Ralph Weissleder; Fiscal Year: 2007
    ..The ultimate goal of this research is to develop clinically useful imaging tools for the molecular assessment of atherosclerosis in vivo, which are currently limited. [unreadable] [unreadable] [unreadable]..
  9. Novel Ternary Ligand 99m Tc-Nitrido Complexes as Heart Imaging Agents
    Shuang Liu; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. Novel Cationic 99mTc Complexes for Heart Imaging
    Shuang Liu; Fiscal Year: 2006
    ..Successful development of new 99mTc perfusion imaging agents will have a profound impact on diagnostic evaluation, risk stratification, and therapeutic decision-making in patients with CAD. ..
  11. Improved Detection of Cancer Using Bi Specific Antibody
    ROBERT SHARKEY; Fiscal Year: 2002
    ....
  12. Improved Detection of Cancer Using Bi Specific Antibody
    ROBERT SHARKEY; Fiscal Year: 2003
    ....
  13. RAIT of Pancreatic Cancer with Humanized PAM4
    ROBERT SHARKEY; Fiscal Year: 2005
    ..The trial will be conducted at the Garden State Cancer Center and Johns Hopkins University School of Medicine. CMMI will be responsible for monitoring the study's progress. ..
  14. Diffuse optical tomography system for molecular imaging
    Ralph Weissleder; Fiscal Year: 2005
    ....
  15. Radioimmunotherapy of CD20+ Lymphomas & CD45+Leukemias
    JOHN PAGEL; Fiscal Year: 2008
    ..abstract_text> ..
  16. Bispecific Antibody Pretargeted Therapy of Pancreatic Cancer
    ROBERT SHARKEY; Fiscal Year: 2008
    ..Overall, these studies will assist in establishing whether this type of pretargeting approach could have a role in the clinical management of pancreatic cancer. [unreadable] [unreadable] [unreadable]..
  17. Bispecific Antibody Pretargeting for Therapy
    ROBERT SHARKEY; Fiscal Year: 2009
    ..Anti-antibody responses will also be measured to the humanized bsMAb. This clinical trial will be conducted at the Fox Chase Cancer Center. ..