atp synthetase complexes

Summary

Summary: Multisubunit enzyme complexes that synthesize ADENOSINE TRIPHOSPHATE from energy sources such as ions traveling through channels.

Top Publications

  1. ncbi Both rotor and stator subunits are necessary for efficient binding of F1 to F0 in functionally assembled Escherichia coli ATP synthase
    Thomas Krebstakies
    Fachbereich Biologie chemie, Abteilung Mikrobiologie, Universitat Osnabruck, D 49069 Osnabruck, Germany
    J Biol Chem 280:33338-45. 2005
  2. ncbi The ATP synthase: the understood, the uncertain and the unknown
    John E Walker
    MRC Mitochondrial Biology Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
    Biochem Soc Trans 41:1-16. 2013
  3. ncbi Measurement of the molecular masses of hydrophilic and hydrophobic subunits of ATP synthase and complex I in a single experiment
    Joe Carroll
    Mitochondrial Biology Unit, Medical Research Council, Hills Road, Cambridge CB2 0XY, UK
    Anal Biochem 395:249-55. 2009
  4. pmc The proton-driven rotor of ATP synthase: ohmic conductance (10 fS), and absence of voltage gating
    Boris A Feniouk
    Division of Biophysics, Faculty of Biology Chemistry, University of Osnabruck, Osnabruck, Germany
    Biophys J 86:4094-109. 2004
  5. ncbi Redox regulation of the rotation of F(1)-ATP synthase
    D Bald
    PRESTO, Chemical Resources Laboratory, Tokyo Institute of Technology, Nagatsuta 4259, Japan
    J Biol Chem 276:39505-7. 2001
  6. ncbi Cysteine-reactive fluorescence probes of catalytic sites of ATP synthase
    Joachim Weber
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arch Biochem Biophys 397:1-10. 2002
  7. ncbi Acute toxicity of triorganotin compounds: different specific effects on the energy metabolism and role of pH
    Rene W Hunziker
    Swiss Federal Institute for Environmental Science and Technology, Duebendorf
    Environ Toxicol Chem 21:1191-7. 2002
  8. ncbi Probing the functional tolerance of the b subunit of Escherichia coli ATP synthase for sequence manipulation through a chimera approach
    Yumin Bi
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Biochim Biophys Acta 1777:583-91. 2008
  9. ncbi A higher plant mitochondrial homologue of the yeast m-AAA protease. Molecular cloning, localization, and putative function
    Marta Kolodziejczak
    Institute of Biochemistry and Molecular Biology, University of Wroclaw, Tamka 2, Poland
    J Biol Chem 277:43792-8. 2002
  10. ncbi Structural and functional analysis of the coupling subunit F in solution and topological arrangement of the stalk domains of the methanogenic A1AO ATP synthase
    Ingmar Schafer
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore
    J Bioenerg Biomembr 38:83-92. 2006

Scientific Experts

Detail Information

Publications144 found, 100 shown here

  1. ncbi Both rotor and stator subunits are necessary for efficient binding of F1 to F0 in functionally assembled Escherichia coli ATP synthase
    Thomas Krebstakies
    Fachbereich Biologie chemie, Abteilung Mikrobiologie, Universitat Osnabruck, D 49069 Osnabruck, Germany
    J Biol Chem 280:33338-45. 2005
    ..The subunit c ring plays a crucial role in the binding of F1 to F0, whereas subunit a does not contribute significantly...
  2. ncbi The ATP synthase: the understood, the uncertain and the unknown
    John E Walker
    MRC Mitochondrial Biology Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
    Biochem Soc Trans 41:1-16. 2013
    ..Here the enzymes form supermolecular complexes, possibly with specific lipids, and these complexes probably contribute to, or even determine, the formation of the cristae...
  3. ncbi Measurement of the molecular masses of hydrophilic and hydrophobic subunits of ATP synthase and complex I in a single experiment
    Joe Carroll
    Mitochondrial Biology Unit, Medical Research Council, Hills Road, Cambridge CB2 0XY, UK
    Anal Biochem 395:249-55. 2009
    ..It could be applied to other respiratory and photosynthetic complexes and, in general, to any protein complex that contains both hydrophilic and hydrophobic subunits...
  4. pmc The proton-driven rotor of ATP synthase: ohmic conductance (10 fS), and absence of voltage gating
    Boris A Feniouk
    Division of Biophysics, Faculty of Biology Chemistry, University of Osnabruck, Osnabruck, Germany
    Biophys J 86:4094-109. 2004
    ..The data fit attributed pK values of approximately 6 and approximately 10 to these relays, and placed them close to the membrane/electrolyte interface...
  5. ncbi Redox regulation of the rotation of F(1)-ATP synthase
    D Bald
    PRESTO, Chemical Resources Laboratory, Tokyo Institute of Technology, Nagatsuta 4259, Japan
    J Biol Chem 276:39505-7. 2001
    ..These findings obtained by the single molecule analysis therefore provide new insights into the mechanisms of enzyme regulation...
  6. ncbi Cysteine-reactive fluorescence probes of catalytic sites of ATP synthase
    Joachim Weber
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arch Biochem Biophys 397:1-10. 2002
    ..The signal of the latter responds differentially to nucleoside diphosphate versus triphosphate bound in catalytic sites...
  7. ncbi Acute toxicity of triorganotin compounds: different specific effects on the energy metabolism and role of pH
    Rene W Hunziker
    Swiss Federal Institute for Environmental Science and Technology, Duebendorf
    Environ Toxicol Chem 21:1191-7. 2002
    ..It was concluded that chromatophores of R. sphaeroides are a useful system to discriminate various effects of toxicants on the energy metabolism of a cell...
  8. ncbi Probing the functional tolerance of the b subunit of Escherichia coli ATP synthase for sequence manipulation through a chimera approach
    Yumin Bi
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Biochim Biophys Acta 1777:583-91. 2008
    ..These studies provide insight into the structural and sequential requirements for stator stalk function...
  9. ncbi A higher plant mitochondrial homologue of the yeast m-AAA protease. Molecular cloning, localization, and putative function
    Marta Kolodziejczak
    Institute of Biochemistry and Molecular Biology, University of Wroclaw, Tamka 2, Poland
    J Biol Chem 277:43792-8. 2002
    ..Based on biochemical experiments using isolated pea mitochondria, we propose that PsFtsH-like m-AAA is involved in the accumulation of the subunit 9 of the ATP synthase in the mitochondrial membrane...
  10. ncbi Structural and functional analysis of the coupling subunit F in solution and topological arrangement of the stalk domains of the methanogenic A1AO ATP synthase
    Ingmar Schafer
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore
    J Bioenerg Biomembr 38:83-92. 2006
    ..Based on these data the surface of contact of B-F could be mapped in the high-resolution structure of subunit B of the A(1)A(O) ATP synthase...
  11. ncbi Cardiolipin stabilizes respiratory chain supercomplexes
    Kathy Pfeiffer
    Zentrum der Biologischen Chemie, Universitatsklinikum Frankfurt, D 60590 Frankfurt, Germany
    J Biol Chem 278:52873-80. 2003
    ..We show that a cardiolipin-deficient strain harbored almost inactive resting cytochrome c oxidase in the membrane. Transition to the fully active pulsed state occurred on a minute time scale...
  12. ncbi Rotary movements within the ATP synthase do not constitute an obligatory element of the catalytic mechanism
    Jan A Berden
    Swammerdam Institute for Life Sciences, BioCentrum, University of Amsterdam, Plantage Muidergracht 12, 1018 TV, Amsterdam, The Netherlands
    IUBMB Life 55:473-81. 2003
    ..Finally a brief characterization of the various nucleotide binding sites is provided and a suggestion is made how the enzyme has evolutionarily developed from a rotating machine into an asymmetrical device for energy conservation...
  13. ncbi Crystal structure of the archaeal A1Ao ATP synthase subunit B from Methanosarcina mazei Gö1: Implications of nucleotide-binding differences in the major A1Ao subunits A and B
    Ingmar B Schäfer
    Universitat des Saarlandes, Fachrichtung 2 3 and 2 5, D 66421 Homburg, Germany
    J Mol Biol 358:725-40. 2006
    ..The arrangement of subunit B within the intact A1Ao ATP synthase is presented...
  14. ncbi Complete inhibition and partial Re-activation of single F1-ATPase molecules by tentoxin: new properties of the re-activated enzyme
    Penka Pavlova
    Department of Structural Biology, Faculty of Earth and Life Science, Vrije Universiteit Amsterdam, The Netherlands
    J Biol Chem 279:9685-8. 2004
    ....
  15. ncbi Phospholipids occupy the internal lumen of the c ring of the ATP synthase of Escherichia coli
    Benjamin Oberfeld
    Institut fur Mikrobiologie, ETH Zurich, 8093 Zurich, Switzerland
    Biochemistry 45:1841-51. 2006
    ..We conclude therefore that the inner lumen of the c ring is occupied with phospholipids. No evidence was found for an extension of subunit a into this space...
  16. pmc ATP synthesis without R210 of subunit a in the Escherichia coli ATP synthase
    Robert R Ishmukhametov
    Department of Biological Sciences, Box 750376, Southern Methodist University, Dallas, TX 75275 0376, USA
    Biochim Biophys Acta 1777:32-8. 2008
    ..The results suggest that minimal requirements for proton translocation by the ATP synthase include a positive charge in subunit a and a weak interface between subunit a and oligomeric subunit c...
  17. pmc Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold
    J E Walker
    EMBO J 1:945-51. 1982
    ....
  18. pmc The 2.8-A structure of rat liver F1-ATPase: configuration of a critical intermediate in ATP synthesis/hydrolysis
    M A Bianchet
    Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Proc Natl Acad Sci U S A 95:11065-70. 1998
    ..Incorporation of this structure suggests a mechanism of ATP synthesis/hydrolysis in which configurations of the enzyme with three bound nucleotides play an essential role...
  19. ncbi Role of the asymmetry of the homodimeric b2 stator stalk in the interaction with the F1 sector of Escherichia coli ATP synthase
    Kristi S Wood
    Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 282:31920-7. 2007
    ..These results imply that the polypeptide in the bN position is more important for F1 binding than the one in the bC position and illustrate the significance of the asymmetry of the b dimer in the enzyme...
  20. ncbi Respiratory chain supercomplexes of mitochondria and bacteria
    Hermann Schagger
    Biochemie I, Zentrum der Biologischen Chemie, Universitatsklinikum Frankfurt, Theodor Stern Kai 7, Haus 25B, D 60590 Frankfort on the Main, Germany
    Biochim Biophys Acta 1555:154-9. 2002
    ..A dimeric state of ATP synthase seems to be specific for mitochondria. Exclusively, monomeric ATP synthase was found in Acetobacterium woodii, in P. denitrificans, and in spinach chloroplasts...
  21. ncbi Evolutionary selective pressure on three mitochondrial SNPs is consistent with their influence on metabolic efficiency in Pima Indians
    Srikar Chamala
    Department of Integrative Biology, Brigham Young University, 699 WIDB, Provo, UT 84602, USA
    Int J Bioinform Res Appl 3:504-22. 2007
    ..Our results suggest that two SNPs were affected by selection during mammalian evolution in a manner consistent with their effects on metabolic efficiency in Pima Indians...
  22. ncbi The contribution of uncoupling protein and ATP synthase to state 3 respiration in Acanthamoeba castellanii mitochondria
    Wiesława Jarmuszkiewicz
    Laboratory of Bioenergetics, Adam Mickiewicz University, Poznan, Poland
    Acta Biochim Pol 51:533-8. 2004
    ..castellanii mitochondria fully depleted of free fatty acid-activated and describes how the two contributions vary when the rate of succinate dehydrogenase is decreased by succinate uptake limitation...
  23. ncbi Angiostatin is directly cytotoxic to tumor cells at low extracellular pH: a mechanism dependent on cell surface-associated ATP synthase
    Sulene L Chi
    Department of Pathology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
    Cancer Res 66:875-82. 2006
    ..Furthermore, these data provide evidence that extracellular ATP synthase plays a role in regulating pH(i) in cells challenged by acidosis...
  24. ncbi A research journey with ATP synthase
    Paul D Boyer
    Molecular Biology Institute, UCLA, Los Angeles, California 90095 1570, USA
    J Biol Chem 277:39045-61. 2002
  25. ncbi Thyroid hormone increases transcription of GA-binding protein/nuclear respiratory factor-2 alpha-subunit in rat liver
    Angeles Rodriguez-Pena
    Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    FEBS Lett 514:309-14. 2002
    ..The results also support the notion that ATP synthase beta-subunit is regulated by TH through the indirect activation of GABP/NRF-2...
  26. ncbi Effect of the mitochondrial transition pore inhibitor, S-15176, on rat liver mitochondria: ATP synthase modulation and mitochondrial uncoupling induction
    Didier Morin
    INSERM, U660, Creteil F 94010, France Université Paris XII, Creteil F 94010, France
    Biochem Pharmacol 72:911-8. 2006
    ..These data demonstrate that S-15176 interacts with several targets in mitochondria and these pharmacological properties should be considered in the examination of its health benefits as well as its potential cytotoxicity...
  27. ncbi Expression of bovine F1-ATPase with functional complementation in yeast Saccharomyces cerevisiae
    Neeti Puri
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Greenbay Road, North Chicago, IL 60064, USA
    J Biol Chem 280:22418-24. 2005
    ....
  28. ncbi Identification of amino-acid substitutions in the proteolipid subunit of the ATP synthase from dicyclohexylcarbodiimide-resistant mutants of Escherichia coli
    J Hoppe
    Eur J Biochem 112:17-24. 1980
    ..Its polypeptide chain would have to fold back to bring together these two residues separated by a segment of 32 residues...
  29. ncbi The b and delta subunits of the Escherichia coli ATP synthase interact via residues in their C-terminal regions
    D T McLachlin
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5C1
    J Biol Chem 273:15162-8. 1998
    ..These results indicate that the b and delta subunits interact via their C-terminal regions and that this interaction is instrumental in the binding of the F1 sector to the b subunit of F0...
  30. ncbi The organization and sequence of the genes for ATP synthase subunits in the cyanobacterium Synechococcus 6301. Support for an endosymbiotic origin of chloroplasts
    A L Cozens
    J Mol Biol 194:359-83. 1987
    ..coli enzyme.4+off..
  31. pmc The atp operon: nucleotide sequence of the region encoding the alpha-subunit of Escherichia coli ATP-synthase
    N J Gay
    Nucleic Acids Res 9:2187-94. 1981
    ..It comprises 1539 nucleotides corresponding to a protein of 513 amino acids...
  32. pmc Nuclear gene dosage effects upon the expression of maize mitochondrial genes
    D L Auger
    Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Genetics 157:1711-21. 2001
    ..These results support the concept that although mitochondrial genes are prokaryotic in origin, their regulation has been extensively integrated into the eukaryotic cell...
  33. ncbi Mitoproteome plasticity of rat brown adipocytes in response to cold acclimation
    Rachel Navet
    Laboratory of Bioenergetics, and Centre de Recherche en Neurobiologie Cellulaire et Moléculaire, Liege, Belgium
    J Proteome Res 6:25-33. 2007
    ..Moreover, these results support the fact that adipocytes can balance their ATP synthesis and their heat production linked to UCP1-sustained uncoupling...
  34. ncbi A new member of a family of ATPases is essential for assembly of mitochondrial respiratory chain and ATP synthetase complexes in Saccharomyces cerevisiae
    A Tzagoloff
    Department of Biological Sciences, Columbia University, New York, New York 10027
    J Biol Chem 269:26144-51. 1994
    ..One, located in the amino-terminal half, contains two hydrophobic stretches of sufficient length to span a membrane lipid bilayer...
  35. ncbi Calcium homeostasis in Pseudomonas aeruginosa requires multiple transporters and modulates swarming motility
    Manita Guragain
    Department of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK, United States
    Cell Calcium 54:350-61. 2013
    ..The lack of PA3920 and vanadate treatment abolished Ca(2+)-induced swarming, suggesting the role of the P-type ATPase in regulating P. aeruginosa response to Ca(2+). ..
  36. ncbi Esophageal ATP synthase and keratinocyte growth factor gene expression changes after acid and bile-induced mucosal damage
    K Szentpali
    Institute of Surgical Research, University of Szeged, P O Box 427, 6701, Szeged, Hungary
    Inflamm Res 54:152-7. 2005
    ....
  37. ncbi Diarylquinolines target subunit c of mycobacterial ATP synthase
    Anil Koul
    Department of Antimicrobial Research, Tibotec BVBA, Johnson and Johnson, Turnhoutseweg 30, B 2340 Beerse, Belgium
    Nat Chem Biol 3:323-4. 2007
    ..Here we establish by genetic, biochemical and binding assays that the oligomeric subunit c (AtpE) of ATP synthase is the target of R207910. Thus targeting energy metabolism is a new, promising approach for antibacterial drug discovery...
  38. pmc Endocrine and metabolic signaling in retroperitoneal white adipose tissue remodeling during cold acclimation
    Aleksandra Jankovic
    Department of Physiology, Institute for Biological Research Sinisa Stankovic, University of Belgrade, 11060 Belgrade, Serbia
    J Obes 2013:937572. 2013
    ..It seems that AMPK α mediate adiponectin effects on metabolic remodeling RpWAT during cold acclimation...
  39. pmc Pharmacokinetics and pharmacodynamics of TMC207 and its N-desmethyl metabolite in a murine model of tuberculosis
    Marie Claude Rouan
    Tibotec BVBA, Johnson and Johnson, Beerse, Belgium
    Antimicrob Agents Chemother 56:1444-51. 2012
    ..The PK-PD profile supports intermittent administration of TMC207, in agreement with its slow release from tissues...
  40. ncbi Evaluation of phenanthrene toxicity on earthworm (Eisenia fetida): an ecotoxicoproteomics approach
    Shijin Wu
    College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People s Republic of China
    Chemosphere 93:963-71. 2013
    ..The variable levels and trends in these spots could play a potential role as novel biomarkers for monitoring the levels of phenanthrene contamination in soil ecosystems...
  41. pmc Speed switching of gonococcal surface motility correlates with proton motive force
    Rainer Kurre
    Department of Physics and Biocenter, University of Cologne, Koln, Germany
    PLoS ONE 8:e67718. 2013
    ..We conclude that depletion of PMF triggers speed switching of gonococcal pili. Although ATP is required for gonococcal pilus retraction, our data indicate that PMF is an independent additional energy source driving the high speed mode. ..
  42. ncbi Bacterial Na+ - or H+ -coupled ATP synthases operating at low electrochemical potential
    Peter Dimroth
    Institut fur Mikrobiologie, Eidgenossische Technische Hochschule, ETH Zentrum, Schmelzbergstrasse 7, CH 8092 Zurich, Switzerland
    Adv Microb Physiol 49:175-218. 2004
    ....
  43. pmc Energized outer membrane and spatial separation of metabolic processes in the hyperthermophilic Archaeon Ignicoccus hospitalis
    Ulf Küper
    Institute for Microbiology and Archaeal Center, Universitat Regensburg, D 93053 Regensburg, Germany
    Proc Natl Acad Sci U S A 107:3152-6. 2010
    ..This raises questions regarding the function of the two membranes, the interaction between these compartments, and the general definition of a cytoplasmic membrane...
  44. ncbi Catalytic and regulatory roles of divalent metal cations on the phosphoryl-transfer mechanism of ADP-dependent sugar kinases from hyperthermophilic archaea
    Felipe Merino
    Laboratorio de Bioquimica y Biologia Molecular, Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Casilla 653, Santiago, Chile
    Biochimie 94:516-24. 2012
    ....
  45. pmc Selective decrease of components of the creatine kinase system and ATP synthase complex in chronic Chagas disease cardiomyopathy
    Priscila Camillo Teixeira
    Laboratory of Immunology, Heart Institute, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    PLoS Negl Trop Dis 5:e1205. 2011
    ....
  46. pmc The beta subunit loop that couples catalysis and rotation in ATP synthase has a critical length
    Nelli Mnatsakanyan
    Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409 1061, USA
    J Biol Chem 286:29788-96. 2011
    ..An AALSAAA mutant in which all negative charges of the DELSEED motif were removed showed a normal pattern for MgATP binding to the catalytic sites, with a clearly present high-affinity site...
  47. ncbi How the N-terminal extremity of Saccharomyces cerevisiae IF1 interacts with ATP synthase: a kinetic approach
    Tiona Andrianaivomananjaona
    Service de Bioenergetique, Biologie Structurale et Mécanismes and CNRS URA 2096, iBiTec S, CEA Saclay, F 91191 Gif sur Yvette, France Univ Paris Sud, LRA 17 V, F91405 Orsay, France
    Biochim Biophys Acta 1807:197-204. 2011
    ..Moreover, the data obtained using chimeric PsaE-IF1 suggest that before binding IF1 presents to the enzyme with its middle part facing a catalytic interface and its Nter extremity folded in the opposite direction...
  48. ncbi Comparative analysis of cells and proteins of pumpkin plants for the control of fruit size
    Yumiko Nakata
    Department of Applied Life Science, Sojo University, 4 22 1 Ikeda, Kumamoto City 860 0082, Japan
    J Biosci Bioeng 114:334-41. 2012
    ..These results provide a step toward the development of plant biotechnology to control fruit size in the future...
  49. pmc Identification of novel targets for miR-29a using miRNA proteomics
    Rhishikesh Bargaje
    Functional Genomics Unit, Council of Scientific Industrial Research Institute of Genomics and Integrative Biology, Delhi, India
    PLoS ONE 7:e43243. 2012
    ..However, this approach was valuable for rapid assessment of the impact of the miRNAs on the cellular proteome and its biological role in apoptosis...
  50. ncbi Tributyltin-resistant Methanothermobacter thermautotrophicus mutant with mutational substitutions in the A1A0-ATP synthase operon
    Zuzana Novakova
    Institute of Animal Biochemistry and Genetics, Slovak Academy of Sciences, Ivanka pri Dunaji, Slovak Republic
    FEMS Microbiol Lett 298:255-9. 2009
    ..The results imply that change of TBT sensitivities of TBT-resistant mutant is due to mutational substitutions in the A(1)A(0)-ATP synthase operon...
  51. pmc Domain features of the peripheral stalk subunit H of the methanogenic A1AO ATP synthase and the NMR solution structure of H(1-47)
    Goran Biukovic
    School of Biological Sciences, Nanyang Technological University, Singapore
    Biophys J 97:286-94. 2009
    ..H(1-47) revealed a strip of alanines involved in dimerization, which were tested by exchange to single cysteines in subunit H mutants...
  52. ncbi Subchronic exposure to arsenic decreased Sdha expression in the brain of mice
    Yan Hong
    Department of Occupational and Environmental Health, Dalian Medical University, No 9 Western Section of Lushun South Road, Dalian, Liaoning 116044, China
    Neurotoxicology 30:538-43. 2009
    ..It implies that the increased level of ROS by As may also be a factor in the disrupting Sdha expression in brain tissue of mice exposed to As...
  53. ncbi A perspective on Peter Mitchell and the chemiosmotic theory
    Peter R Rich
    Glynn Laboratory of Bioenergetics, Institute of Structural and Molecular Biology, University College London, Gower Street, London, UK
    J Bioenerg Biomembr 40:407-10. 2008
    ..I here review some of his views of that time on structures and mechanisms of several key bioenergetic components in relation to the subsequent advances that have been made...
  54. ncbi Supramolecular organization of protein complexes in the mitochondrial inner membrane
    Janet Vonck
    Department of Structural Biology, Max Planck Institute of Biophysics, Max von Laue Strasse 3, D 60438 Frankfurt am Main, Germany
    Biochim Biophys Acta 1793:117-24. 2009
    ..Together these observations show that the mitochondrial inner membrane is highly organised and that the molecular events leading to ATP synthesis are carefully coordinated...
  55. pmc Crystallization of the c14-rotor of the chloroplast ATP synthase reveals that it contains pigments
    Benjamin Varco-Merth
    Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona, USA 85287, USA
    Biochim Biophys Acta 1777:605-12. 2008
    ....
  56. pmc Roles of AtpI and two YidC-type proteins from alkaliphilic Bacillus pseudofirmus OF4 in ATP synthase assembly and nonfermentative growth
    Jun Liu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA
    J Bacteriol 195:220-30. 2013
    ..Deletion of atpZ caused the largest increase among the mutants in magnesium concentrations needed for pH 7.5 growth. The basis for this phenotype is not yet resolved...
  57. ncbi Selective and ATP-driven transport of ions across supported membranes into nanoporous carriers using gramicidin A and ATP synthase
    Vitaliy Oliynyk
    Department of Materials and Environmental Chemistry, Stockholm University, 10691 Stockholm, Sweden
    Phys Chem Chem Phys 15:2733-40. 2013
    ....
  58. ncbi Regulation of the biogenesis of OXPHOS complexes in cell transition from replicating to quiescent state: involvement of PKA and effect of hydroxytyrosol
    Anna Signorile
    Department of Basic Medical Sciences, Neurosciences and Sense organs, University of Bari Aldo Moro, Bari 70124, Italy Electronic address
    Biochim Biophys Acta 1843:675-84. 2014
    ..These results show involvement of PKA, CREB and PGC-1α in the regulation of OXPHOS in cell transition from the replicating to the quiescent state. ..
  59. pmc New mutations in the mycobacterial ATP synthase: new insights into the binding of the diarylquinoline TMC207 to the ATP synthase C-ring structure
    Elena Segala
    Laboratoire de Bacteriologie Hygiene, ER5 EA1541, UPMC Universite Paris 06, Faculté de Médecine Pitié Salpêtrière, Paris, France
    Antimicrob Agents Chemother 56:2326-34. 2012
    ..These data shed light on the molecular interactions allowing TMC207 to bind specifically and efficiently at the level of the proton-binding site of the mycobacterial C ring...
  60. ncbi Identification of differentially expressed genes in human trophoblast cells by differential-display RT-PCR
    G Huch
    Institut fur Anatomie, Universitatsklinikum, Universität GH Essen, Germany
    Placenta 19:557-67. 1998
    ..This expression pattern suggests that the newly identified molecule, PBK1, could be involved in the regulation of proliferation/ differentiation and potentially in invasion of trophoblast cells...
  61. ncbi Aromatase inhibition affects testosterone-induced masculinization of song and the neural song system in female canaries
    Leonida Fusani
    Research Centre for Ornithology of the Max Planck Society, 82346 Andechs, Germany
    J Neurobiol 54:370-9. 2003
    ..Our results provide the first example of estrogen-sensitive mechanisms controlling the structural features of adult birdsong...
  62. ncbi Tracing clonality of Helicobacter pylori infecting family members from analysis of DNA sequences of three housekeeping genes (ureI, atpA and ahpC), deduced amino acid sequences, and pathogenicity-associated markers (cagA and vacA)
    Robert J Owen
    Helicobacter Reference Unit, Laboratory of Enteric Pathogens, Health Protection Agency, London, UK
    J Med Microbiol 52:515-24. 2003
    ..Analysis of these three housekeeping genes provides unique evidence for precise tracing of clonal descent in isolates of H. pylori in family groups...
  63. ncbi Molecular phylogenetics and biogeography of transisthmian and amphi-Atlantic needlefishes (Belonidae: Strongylura and Tylosurus): perspectives on New World marine speciation
    H M Banford
    Department of Biology, State University of West Georgia, Carrollton, 30118, USA
    Mol Phylogenet Evol 31:833-51. 2004
    ....
  64. ncbi The ATP synthase of Escherichia coli: structure and function of F(0) subunits
    G Deckers-Hebestreit
    Abteilung Mikrobiologie, Fachbereich Biologie chemie, Universitat Osnabruck, D 49069, Osnabruck, Germany
    Biochim Biophys Acta 1458:364-73. 2000
    ..Consequences on the coupling mechanism between ATP synthesis/hydrolysis and proton translocation are discussed...
  65. ncbi Genetic fusions of globular proteins to the epsilon subunit of the Escherichia coli ATP synthase: Implications for in vivo rotational catalysis and epsilon subunit function
    Daniel J Cipriano
    Department of Biochemistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 277:16782-90. 2002
    ..It is proposed that the C-terminal domain of epsilon functions to ensure that rotation occurs only in the direction of ATP synthesis when ADP is bound and only in the direction of hydrolysis when ATP is bound...
  66. pmc The atp operon: nucleotide sequence of the genes for the gamma, beta, and epsilon subunits of Escherichia coli ATP synthase
    M Saraste
    Nucleic Acids Res 9:5287-96. 1981
    ..The genes for the alpha and beta subunits have evolved from a common ancestor...
  67. pmc Inhibition of ATP synthase by chlorinated adenosine analogue
    Lisa S Chen
    Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Biochem Pharmacol 78:583-91. 2009
    ..Collectively, our current work suggests that 8-Cl-ADP may serve as a substrate and the 8-Cl-ATP may be an inhibitor of ATP synthase...
  68. ncbi Mitochondrial oxidative injury and energy metabolism alteration in rat fatty liver: effect of the nutritional status
    G Vendemiale
    Department of Internal and Public Medicine (DIMIMP, University of Bari, Italy
    Hepatology 33:808-15. 2001
    ..These changes, which are greatly exacerbated after starvation, may account for the reduced synthesis of the hepatic ATP observed in the presence of fatty infiltration...
  69. ncbi Isolation and characterization of a novel antistress gene from Chlamydomonas sp. W80
    Yoshito Suda
    Department of Environmental Biotechnology, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka, Japan
    J Biosci Bioeng 107:352-4. 2009
    ..Intracellular ATP concentration and stress-tolerance of Escherichia coli were increased by transformation with WCFII. We propose that WCFII-mediated stress tolerance is due to enhanced accumulation of intracellular ATP...
  70. pmc Engineering rotor ring stoichiometries in the ATP synthase
    Denys Pogoryelov
    Department of Structural Biology, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany
    Proc Natl Acad Sci U S A 109:E1599-608. 2012
    ..These results provide the basis for bioengineering ATP synthases with customized ion-to-ATP ratios, by sequence modifications...
  71. pmc Slow-twitch fiber proportion in skeletal muscle correlates with insulin responsiveness
    Charles A Stuart
    Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, P O Box 70622, Johnson City, Tennessee 37614 0622, USA
    J Clin Endocrinol Metab 98:2027-36. 2013
    ..The metabolic syndrome, characterized by central obesity with dyslipidemia, hypertension, and hyperglycemia, identifies people at high risk for type 2 diabetes...
  72. pmc Drosophila cyclin D/Cdk4 regulates mitochondrial biogenesis and aging and sensitizes animals to hypoxic stress
    Amalia Icreverzi
    Basic Science Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cell Cycle 11:554-68. 2012
    ....
  73. ncbi A novel acyclic oligomycin A derivative formed via retro-aldol rearrangement of oligomycin A
    Lyudmila N Lysenkova
    Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, Moscow, Russian Federation
    J Antibiot (Tokyo) 65:405-11. 2012
    ....
  74. pmc Delayed accumulation of intestinal coliform bacteria enhances life span and stress resistance in Caenorhabditis elegans fed respiratory deficient E. coli
    Fernando Gomez
    Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    BMC Microbiol 12:300. 2012
    ..Here we explore the mechanisms accounting for the enhanced nematode life span in response to these diets...
  75. ncbi Proteomic analysis of plasma from a Tau transgenic mouse
    Yoon Ha Kim
    School of Life Sciences and Biotechnology, Korea University, Seoul 138 701, Republic of Korea
    Int J Dev Neurosci 30:277-83. 2012
    ..This study suggests that these proteins could be used as candidate biomarkers for early diagnosis of AD in combination with previously discovered protein biomarkers...
  76. ncbi Periglandula, a new fungal genus within the Clavicipitaceae and its association with Convolvulaceae
    Ulrike Steiner
    Institut für Nutzpflanzenwissenschaften und Ressourcenschutz Phytomedizin, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Mycologia 103:1133-45. 2011
    ..Based on these findings we propose a new fungal genus, Periglandula, gen. nov., and describe two new species, Periglandula ipomoeae sp. nov., from host plant I. asarifolia, and Periglandula turbinae sp. nov., from T. corymbosa...
  77. pmc A conformational change of the γ subunit indirectly regulates the activity of cyanobacterial F1-ATPase
    Ei Ichiro Sunamura
    Chemical Resources Laboratory, Tokyo Institute of Technology, Nagatsuta 4259 R1 8, Midori ku, Yokohama 226 8503, Japan
    J Biol Chem 287:38695-704. 2012
    ..These results imply that the global conformational change of the γ subunit indirectly regulates complex activity by changing both ADP inhibition and ε inhibition...
  78. ncbi Comparative mtDNA phylogeography of neotropical freshwater fishes: testing shared history to infer the evolutionary landscape of lower Central America
    E Bermingham
    Smithsonian Tropical Research Institute, Balboa, Republic of Panama
    Mol Ecol 7:499-517. 1998
    ..Thus, the fisheye view of LCA suggests a complex biogeographic history of overlaid cycles of colonization, diversification, sorting and extinction of lineages...
  79. pmc TMC207: the first compound of a new class of potent anti-tuberculosis drugs
    Alberto Matteelli
    Institute of Infectious and Tropical Diseases, University of Brescia, Italy
    Future Microbiol 5:849-58. 2010
    ....
  80. ncbi Identification of four genes of the Brucella melitensis ATP synthase operon F0 sector: relationship with the Rhodospirillaceae family
    R Hernández-Castro
    Departamento de Microbiologia e Inmunologia, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, Coyoacan, Mexico
    Microb Comp Genomics 5:163-71. 2000
    ..This feature has been found only in photosynthetic bacteria and chloroplasts. In addition, the gene cluster was separated from the F1 sector, a characteristic described only for the Rhodospirillaceae family...
  81. pmc Rates and mechanisms of resistance development in Mycobacterium tuberculosis to a novel diarylquinoline ATP synthase inhibitor
    E Huitric
    Swedish Institute for Infectious Disease Control, Solna, Sweden
    Antimicrob Agents Chemother 54:1022-8. 2010
    ..Competition assays showed no measurable reduction in the fitness of the mutants compared to that of the isogenic wild types...
  82. pmc Supply of sulphur to S-deficient young barley seedlings restores their capability to cope with iron shortage
    Stefania Astolfi
    Dipartimento di Agrobiologia e Agrochimica, Universita della Tuscia, Via S C De Lellis snc, I 01100 Viterbo, Italy
    J Exp Bot 61:799-806. 2010
    ..In particular, our results are indicative that barley plants fully recover their capability to cope with Fe shortage after the supply of S is restored to S-deficient plants...
  83. ncbi The nucleotide sequence of the atp genes coding for the F0 subunits a, b, c and the F1 subunit delta of the membrane bound ATP synthase of Escherichia coli
    J Nielsen
    Mol Gen Genet 184:33-9. 1981
    ..The stoichiometry of the F0 sector subunits is discussed and a model is proposed for the functioning of the highly charged b-subunit of the F0 sector as the actual proton conductor...
  84. pmc Purinergic mechanisms in breast cancer support intravasation, extravasation and angiogenesis
    Iain L O Buxton
    Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, United States
    Cancer Lett 291:131-41. 2010
    ..Evidence is presented that blockade of the actions of nucleotides in the setting of newly diagnosed breast cancer may provide a useful adjunct to current anti-angiogenesis treatment...
  85. ncbi Row-like organization of ATP synthase in intact mitochondria determined by cryo-electron tomography
    Natalya V Dudkina
    Electron Microscopy Group, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands
    Biochim Biophys Acta 1797:272-7. 2010
    ..This demonstrates the capability of dual-axis electron tomography to unravel details of proteins and their interactions in complete organelles...
  86. pmc The atp operon: nucleotide sequence of the promoter and the genes for the membrane proteins, and the delta subunit of Escherichia coli ATP-synthase
    N J Gay
    Nucleic Acids Res 9:3919-26. 1981
    ..The three genes that follow are structural genes for proteins comprising the proton channel of the enzyme. The fifth gene codes for the delta-subunit of F(1)-ATPase...
  87. ncbi The unc operon. Nucleotide sequence, regulation and structure of ATP-synthase
    J E Walker
    Biochim Biophys Acta 768:164-200. 1984
  88. ncbi Biochemistry of neuronal ceroid lipofuscinoses
    M A Junaid
    Department of Developmental Biochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA
    Adv Genet 45:93-106. 2001
    ..Identification of natural substrates for the various enzymes involved in NCL may help in the characterization of the cytotoxic factor(s) and also in designing rationale therapeutic interventions for these group of devastating diseases...
  89. ncbi ATP synthase: constrained stoichiometry of the transmembrane rotor
    D J Muller
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    FEBS Lett 504:219-22. 2001
    ..These results suggest the rotor diameter and stoichiometry to be determined by the shape of the subunits and their nearest neighbor interactions...
  90. ncbi Organisation of the yeast ATP synthase F(0):a study based on cysteine mutants, thiol modification and cross-linking reagents
    J Velours
    Institut de Biochimie et Genetique Cellulaires du CNRS, 1 rue Camille Saint Saens, 33077, Cedex, Bordeaux, France
    Biochim Biophys Acta 1458:443-56. 2000
    ..The dimerisation of subunit 4 in the membrane revealed that this component is located in the periphery of the enzyme and interacts with other ATP synthase complexes...
  91. ncbi Lipid raft proteome reveals that oxidative phosphorylation system is associated with the plasma membrane
    Bong Woo Kim
    College of Life Sciences and Biotechnology, Korea University, 1, 5 Ka, Anam Dong, Sungbuk Ku, Seoul, Korea
    Expert Rev Proteomics 7:849-66. 2010
    ..We discuss the findings of OXPHOS complexes in lipid rafts, the role of the surface ATP synthase complex as a receptor for various ligands and extracellular superoxide generation by plasma membrane oxidative phosphorylation complexes...
  92. pmc Supercomplexes in the respiratory chains of yeast and mammalian mitochondria
    H Schagger
    Zentrum der Biologischen Chemie, Universitatsklinikum Frankfurt, D 60590 Frankfurt, Germany
    EMBO J 19:1777-83. 2000
    ..A fraction of total bovine ATP synthase (complex V) was isolated in dimeric form, suggesting that a dimeric state is not limited to S.cerevisiae, but also exists in mammalian mitochondria...
  93. ncbi Oxidation-reduction respiratory chains and ATP synthase complex are localized in detergent-resistant lipid rafts
    Ki Bum Kim
    School of Life Sciences and Biotechnology, Korea University, Anam Dong, Sungbook Ku, Seoul, Korea
    Proteomics 6:2444-53. 2006
    ....
  94. ncbi Chemistry. From electron pump to proton channel
    Kazushi Kinbara
    Department of Chemistry and Biotechnology, School of Engineering, and the Center for NanoBio Integration, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    Science 313:51-2. 2006
  95. ncbi Active proton leak in mitochondria: a new way to regulate substrate oxidation
    Arnaud Mourier
    Universite Bordeaux 2, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Biochim Biophys Acta 1797:255-61. 2010
    ..We propose to name this new mechanism "active proton leak." Such a mechanism could allow a wide modulation of substrate oxidation in response to cellular redox constraints...
  96. pmc Characterization of the expressed genes for subunit c of mitochondrial ATP synthase in sheep with ceroid lipofuscinosis
    S M Medd
    Medical Research Council Laboratory of Molecular Biology, Cambridge, U K
    Biochem J 293:65-73. 1993
    ..However, restriction fragment analysis of genomic DNA from a further 12 sheep established that the sequence differences were not linked to ceroid lipofuscinosis...
  97. ncbi The amino acid sequence of the beta-subunit of ATP synthase from bovine heart mitochondria
    M J Runswick
    J Biol Chem 258:3081-9. 1983
    ..Sci. U.S.A. 79, 6260-6264) shows that the protein is highly conserved. 70% of residues are identical in E. coli and beef mitochondria. This contrasts with some of the other subunits in the enzyme complex which are much less conserved...
  98. ncbi Operation of the F(0) motor of the ATP synthase
    P Dimroth
    Mikrobiologisches Institut, Eidgenossische Technische Hochschule, ETH Zentrum, CH 8092, Zurich, Switzerland
    Biochim Biophys Acta 1458:374-86. 2000
    ..Taken together with biophysical data, the operating principles of the motor have been delineated...
  99. ncbi Binding of subunit E into the A-B interface of the A(1)A(O) ATP synthase
    Cornelia Hunke
    Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore 637551, Republic of Singapore
    Biochim Biophys Acta 1808:2111-8. 2011
    ..1±4.4). Based on the crystallographic structures of the three subunits A, B and E available, the arrangement of the peripheral stalk subunit E in the A-B interface has been modeled, shining light into the A-B-E assembly of this enzyme...
  100. ncbi Identification of differentially expressed proteins in ruminal epithelium in response to a concentrate-supplemented diet
    Angelika Bondzio
    Institute of Veterinary Biochemistry, Freie Universitat Berlin, Germany
    Am J Physiol Gastrointest Liver Physiol 301:G260-8. 2011
    ..These results suggest new candidate proteins that may contribute to a better understanding of the signaling pathways and mechanisms that mediate rumen epithelial adaptation to high-concentrate diet...
  101. ncbi The participation of metals in the mechanism of the F(1)-ATPase
    W D Frasch
    Center for the Study of Early Events in Photosynthesis, Department of Plant Biology, Arizona State University, Tempe, AZ 85287 1601, USA
    Biochim Biophys Acta 1458:310-25. 2000
    ..Coordination of the metal by these carboxyl groups contributes significantly to the ability of the enzyme to bind the nucleotide with high affinity...

Research Grants9

  1. PURINERGIC AXIS OF CARDIAC BLOOD VESSELS
    IAIN BUXTON; Fiscal Year: 2001
    ..We will approach these aims with biochemical, pharmacological, molecular, cell biological and microscopic methods employing intact blood vessels, cells in primary culture and subcellular fractions. ..
  2. MITOCHONDRIAL DNA REARRANGEMENT IN NEUROMUSCULAR DISEASE
    ERIC SCHON; Fiscal Year: 2002
    ..Finally, we will search for potential factors associated with the control of mtDNA copy number. ..
  3. CYTOCHROME OXIDASE ASSEMBLY GENES IN HUMAN DISEASE
    ERIC SCHON; Fiscal Year: 2003
    ..abstract_text> ..
  4. TRANSFECTING MAMMALIAN MITOCHONDRIA WITH EXOGENOUS DNA
    ERIC SCHON; Fiscal Year: 2005
    ....
  5. Mitochondrial control of neuronal excitotoxicity
    David Nicholls; Fiscal Year: 2005
    ..4. To test the hypothesis that mitochondria at specific intracellular locations may be selectively vulnerable to glutamate excitotoxicity because of their proximity to NMDA receptors, or their location in regions of high-energy demand. ..
  6. Aging-Related Models and Mitochondrial Bioenergetics
    David Nicholls; Fiscal Year: 2006
    ..3. To indicate therapeutic strategies whereby the deleterious consequences of aging-related changes in mitochondrial function can be minimized. ..
  7. Factor B and energy coupling in mitochondria
    GRIGORY BELOGRUDOV; Fiscal Year: 2007
    ..The proposed research is expected to advance the knowledge of the molecular mechanisms of energy transfer and conservation in mitochondria, and shed light on the role of mitochondria in a number of human disorders. ..
  8. Molecular Basis for Recognition and Nuclear Import of Non-classical NLS Cargos
    Gino Cingolani; Fiscal Year: 2010
    ..Carry out a quantitative structural and functional analysis of HIV-1 Rev-NLS 3. Define the molecular basis for the recognition of STAT1 "dinner-specific"NLS by importin a-5. ..
  9. F1-ATPase Chemical-Mechanical Coupling Mechanisms
    Wayne D Frasch; Fiscal Year: 2010
    ..abstract_text> ..