catechol o methyltransferase

Summary

Summary: Enzyme that catalyzes the movement of a methyl group from S-adenosylmethionone to a catechol or a catecholamine. EC 2.1.1.6.

Top Publications

  1. pmc Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia
    M F Egan
    Clinical Brain Disorders Branch, Building 10, Center Drive, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:6917-22. 2001
  2. pmc Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain
    Jingshan Chen
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 75:807-21. 2004
  3. ncbi Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders
    H M Lachman
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Pharmacogenetics 6:243-50. 1996
  4. ncbi Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond
    Elizabeth M Tunbridge
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    Biol Psychiatry 60:141-51. 2006
  5. ncbi COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor
    Jon Kar Zubieta
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Science 299:1240-3. 2003
  6. ncbi Genetic basis for individual variations in pain perception and the development of a chronic pain condition
    Luda Diatchenko
    Comprehensive Center for Inflammatory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Hum Mol Genet 14:135-43. 2005
  7. ncbi Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex
    Michael N Smolka
    Central Institute of Mental Health, 68159 Mannheim, Germany
    J Neurosci 25:836-42. 2005
  8. ncbi Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype
    Andreas Meyer-Lindenberg
    Section on Integrative Neuroimaging, National Institute for Mental Health, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, Maryland 20892 1365, USA
    Nat Neurosci 8:594-6. 2005
  9. ncbi Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex
    E M Tunbridge
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom, OX3 7JX
    J Neurosci 24:5331-5. 2004
  10. ncbi Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms
    S Dawling
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Cancer Res 61:6716-22. 2001

Detail Information

Publications283 found, 100 shown here

  1. pmc Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia
    M F Egan
    Clinical Brain Disorders Branch, Building 10, Center Drive, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:6917-22. 2001
    ..These data suggest that the COMT Val allele, because it increases prefrontal dopamine catabolism, impairs prefrontal cognition and physiology, and by this mechanism slightly increases risk for schizophrenia...
  2. pmc Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain
    Jingshan Chen
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 75:807-21. 2004
    ....
  3. ncbi Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders
    H M Lachman
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Pharmacogenetics 6:243-50. 1996
    ..In addition, this polymorphism may have pharmacogenetic significance in that it will help make it possible to identify patients who display altered metabolism of catechol drugs...
  4. ncbi Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond
    Elizabeth M Tunbridge
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    Biol Psychiatry 60:141-51. 2006
    ..We conclude by outlining preliminary data indicating that COMT is a promising therapeutic target for ameliorating the cognitive deficits associated with schizophrenia...
  5. ncbi COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor
    Jon Kar Zubieta
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Science 299:1240-3. 2003
    ..The COMT val158met polymorphism thus influences the human experience of pain and may underlie interindividual differences in the adaptation and responses to pain and other stressful stimuli...
  6. ncbi Genetic basis for individual variations in pain perception and the development of a chronic pain condition
    Luda Diatchenko
    Comprehensive Center for Inflammatory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Hum Mol Genet 14:135-43. 2005
    ..Thus, COMT activity substantially influences pain sensitivity, and the three major haplotypes determine COMT activity in humans that inversely correlates with pain sensitivity and the risk of developing TMD...
  7. ncbi Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex
    Michael N Smolka
    Central Institute of Mental Health, 68159 Mannheim, Germany
    J Neurosci 25:836-42. 2005
    ....
  8. ncbi Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype
    Andreas Meyer-Lindenberg
    Section on Integrative Neuroimaging, National Institute for Mental Health, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, Maryland 20892 1365, USA
    Nat Neurosci 8:594-6. 2005
    ..These data implicate a dopaminergic tuning mechanism in prefrontal cortex and suggest a systems-level mechanism for cognitive and neuropsychiatric associations with COMT...
  9. ncbi Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex
    E M Tunbridge
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom, OX3 7JX
    J Neurosci 24:5331-5. 2004
    ..The interaction between clozapine and tolcapone may have implications for the treatment of schizophrenia...
  10. ncbi Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms
    S Dawling
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Cancer Res 61:6716-22. 2001
    ....
  11. ncbi Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase
    R M Weinshilboum
    Department of Pharmacology, Mayo Medical School Mayo Clinic Mayo Foundation, Rochester, Minnesota 55905, USA
    Annu Rev Pharmacol Toxicol 39:19-52. 1999
    ....
  12. ncbi Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
    P J Harrison
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Mol Psychiatry 10:40-68; image 5. 2005
    ..Characterization of a core molecular pathway and a 'genetic cytoarchitecture' would be a profound advance in understanding schizophrenia, and may have equally significant therapeutic implications...
  13. ncbi Additive effects of genetic variation in dopamine regulating genes on working memory cortical activity in human brain
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, 70124 Bari, Italy
    J Neurosci 26:3918-22. 2006
    ..These results demonstrate additive genetic effects of genes regulating dopamine signaling on specific neuronal networks subserving working memory...
  14. ncbi Catechol-O-methyltransferase (COMT) genotypes and working memory: associations with differing cognitive operations
    Gerard E Bruder
    Department of Psychiatry, Columbia University, New York, USA
    Biol Psychiatry 58:901-7. 2005
    ..This report examines the relation of COMT genotypes to performance on a battery of working memory tests differing in the cognitive operations to be performed on the material...
  15. ncbi Catechol O-methyltransferase Val158Met genotype influences frontoparietal activity during planning in patients with Parkinson's disease
    Caroline H Williams-Gray
    Cambridge Centre for Brain Repair and Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom
    J Neurosci 27:4832-8. 2007
    ....
  16. ncbi Genetic and neurochemical modulation of prefrontal cognitive functions in children
    Adele Diamond
    Center for Developmental Cognitive Neuroscience, Eunice Kennedy Shriver Center Campus, University of Massachusetts Medical School, Waltham 02452, USA
    Am J Psychiatry 161:125-32. 2004
    ..The authors investigated the relation between the COMT gene polymorphism and cognitive performance in children...
  17. ncbi The catechol-O-methyl transferase Val158Met polymorphism and experience of reward in the flow of daily life
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 33:3030-6. 2008
    ..Genetic moderation of ecological measures of reward experience is hypothesized to be of major relevance to the development of various behavioral disorders, including depression and addiction...
  18. ncbi Effect of catechol-O-methyltransferase val158met genotype on attentional control
    Giuseppe Blasi
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
    J Neurosci 25:5038-45. 2005
    ..These results indicate that met allele load and presumably enhanced dopaminergic tone improve the "efficiency" of local circuit processing within the cingulate cortex and thereby its function during AC...
  19. ncbi Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Biol Psychiatry 60:1250-8. 2006
    ..This network includes the hippocampal formation (HF) as well as the ventrolateral prefrontal cortex (VLPFC). Studies in animals have suggested that the relationship between these brain regions is strongly modulated by dopamine...
  20. ncbi Polymorphisms associated with circulating sex hormone levels in postmenopausal women
    Alison M Dunning
    Cancer Research UK, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
    J Natl Cancer Inst 96:936-45. 2004
    ..We investigated the association between levels of sex hormones and single nucleotide polymorphisms (SNPs) in genes coding for the enzymes that regulate them...
  21. ncbi The dopaminergic midbrain participates in human episodic memory formation: evidence from genetic imaging
    Björn H Schott
    Department of Neurology II, Center for Advanced Imaging, University Hospital of Magdeburg, 39120 Magdeburg, Germany
    J Neurosci 26:1407-17. 2006
    ....
  22. ncbi The catechol-O-methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes
    Robert M Bilder
    Department of Psychiatry, David Geffen School of Medicine and Psychology, UCLA Neuropsychiatric Institute, University of California at Los Angeles, Los Angeles, CA, USA
    Neuropsychopharmacology 29:1943-61. 2004
    ....
  23. ncbi Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis
    Jin Bo Fan
    Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences Bio X Life Science Research Center, Shanghai Jiao Tong University, China
    Biol Psychiatry 57:139-44. 2005
    ..It is hypothesized that the high activity Val allele slightly increases risk for schizophrenia through its effect on dopamine-mediated prefrontal information processing...
  24. ncbi Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies
    Stephen J Glatt
    Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center and Massachusetts General Hospital, Boston 02115, USA
    Am J Psychiatry 160:469-76. 2003
    ..The authors' goal was to evaluate the collective evidence for an association between the Val158/108Met polymorphism of the catechol O-methyltransferase (COMT) gene and schizophrenia...
  25. ncbi Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia
    Keizo Kanasaki
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 453:1117-21. 2008
    ....
  26. ncbi Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia
    Kristin K Nicodemus
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD 20892, USA
    Hum Genet 120:889-906. 2007
    ..In addition, we were able to replicate other studies, including allelic directionality. The use of epistatic models may improve replication of psychiatric candidate gene studies...
  27. ncbi Genetic origins of anxiety in women: a role for a functional catechol-O-methyltransferase polymorphism
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    Psychiatr Genet 13:33-41. 2003
    ....
  28. ncbi Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia
    Terry E Goldberg
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 60:889-96. 2003
    ..Cognitive dysfunction in the working memory domain seems to be under genetic control and is a candidate intermediate phenotype in schizophrenia. Genes that affect working memory processing may contribute to risk for schizophrenia...
  29. ncbi Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders
    Paul J Harrison
    Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK
    Neuropsychopharmacology 33:3037-45. 2008
    ..Since sex differences in the genetic architecture of quantitative traits are the rule not the exception, we anticipate that additional evidence will emerge for sexual dimorphisms, not only in COMT but also in many other autosomal genes...
  30. pmc Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function
    Hao Yang Tan
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:12536-41. 2007
    ..These findings extend putative brain dopaminergic and glutamatergic relationships indexed by COMT and GRM3 to a systems-level interaction in human cortical circuits implicated in working memory dysfunction such as in schizophrenia...
  31. ncbi Catechol-O-methyltransferase val108/158met genotype predicts working memory response to antipsychotic medications
    Thomas W Weickert
    National Institutes of Health, National Institute of Mental Health, Clinical Brain Disorders Branch, Building 10, Room 4C 101, MSC 1379, Bethesda, MD 20892, USA
    Biol Psychiatry 56:677-82. 2004
    ..The present study tested the effects of several COMT polymorphisms on the cognitive response to antipsychotic medication in patients with schizophrenia...
  32. ncbi COMT Val108/158 Met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome
    Kate Baker
    Behavioural and Brain Sciences Unit, Institute of Child Health, University College London, London, United Kingdom
    Biol Psychiatry 58:23-31. 2005
    ..We further predicted that the catechol-O-methyltransferase Val(108/158)Met polymorphism, located within the deleted chromosomal segment, would modify the severity of endophenotypic features...
  33. ncbi Association between the COMT Val158Met polymorphism and propensity to anxiety in an Australian population-based longitudinal study of adolescent health
    Craig A Olsson
    Centre for Adolescent Health, Murdoch Children s Research Institute, Royal Children s Hospital, University of Melbourne, Victoria, Australia
    Psychiatr Genet 15:109-15. 2005
    ..Two recent reports have observed the association between the MetMet genotype and risk of anxiety in adult populations. We examined the association between the ValMet genotypes and propensity to anxiety across adolescence...
  34. ncbi Association study of a functional catechol-O-methyltransferase-gene polymorphism and cognitive function in healthy females
    Shih Jen Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, No 201 Shih Pai Road, Sec 2, 11217, Taipei, Taiwan, Republic of China
    Neurosci Lett 338:123-6. 2003
    ....
  35. ncbi Catechol-o-methyltransferase (COMT) and proline dehydrogenase (PRODH) mRNAs in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and major depression
    Elizabeth Tunbridge
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford, OX3 7JX, UK
    Synapse 51:112-8. 2004
    ....
  36. ncbi New evidence of association between COMT gene and prefrontal neurocognitive function in healthy individuals from sibling pairs discordant for psychosis
    Araceli Rosa
    Unitat d Antropologia, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Am J Psychiatry 161:1110-2. 2004
    ....
  37. ncbi Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women
    Shelley S Tworoger
    The Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 13:94-101. 2004
    ..This study provides further evidence that genetic variation may appreciably alter sex hormone concentrations in postmenopausal women not taking hormone therapy...
  38. ncbi Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: differential effects of Val and Met alleles on cognitive stability and flexibility
    Karen A Nolan
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Am J Psychiatry 161:359-61. 2004
    ..They hypothesized that the Val and Met alleles would be associated with deficits in imitation learning and reversal learning, respectively...
  39. ncbi The association between panic disorder and the L/L genotype of catechol-O-methyltransferase
    Jong Min Woo
    Department of Neuropsychiatry, Inje University Seoul Paik Hospital, Seoul, Republic of Korea
    J Psychiatr Res 38:365-70. 2004
    ..002). Our results suggest that the COMT L/L genotype is associated with PD and the genetic variant of the COMT enzyme may be related to the clinical severity and treatment response to paroxetine in PD...
  40. ncbi Brain catecholamine metabolism in catechol-O-methyltransferase (COMT)-deficient mice
    Marko Huotari
    University of Kuopio, Department of Pharmacology and Toxicology, PO Box 1627, FIN 70211 Kuopio, Finland
    Eur J Neurosci 15:246-56. 2002
    ..Our results may have implications for improving the treatment of Parkinson's disease and for understanding the contribution of the natural variation in COMT activity to psychiatric phenotypes...
  41. ncbi Role of the COMT gene Val158Met polymorphism in mental disorders: a review
    Ladislav Hosak
    Department of Psychiatry, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Czech Republic
    Eur Psychiatry 22:276-81. 2007
    ..Gene-gene and gene-environment interactions should also be considered. The COMT gene is probably not "a gene for" any mental disorder, but the Val158Met polymorphism appears to have pleiotropic effects on human behavior...
  42. pmc Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia
    Gilberto Vargas-Alarcon
    National Institute of Cardiology, Juan Badiano 1, Mexico City 14080, Mexico
    Arthritis Res Ther 9:R110. 2007
    ..This association was not observed in Mexican patients. Studies with a larger sample size are needed in order to verify or amend these preliminary results...
  43. ncbi Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome
    H M Lachman
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Med Genet 67:468-72. 1996
    ..We now report that in a population of patients with VCFS, there is an apparent association between the low-activity allele, COMT158met, and the development of bipolar spectrum disorder, and in particular, a rapid-cycling form...
  44. ncbi Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1----q11.2
    M H Grossman
    Department of Pediatrics, Temple University School of Medicine, St Christopher s Hospital For Children, Philadelphia, Pennsylvania 19134
    Genomics 12:822-5. 1992
    ..Southern blot analysis indicates that the human COMT gene is localized to 22q11.1----q11.2, a region to which several anonymous DNA sequences, but until now, no structural genes, have been assigned...
  45. ncbi Evidence for a susceptibility locus for panic disorder near the catechol-O-methyltransferase gene on chromosome 22
    Steven P Hamilton
    Department of Psychiatry, College of Physicians and Surgeons at Columbia University, New York, NY, USA
    Biol Psychiatry 51:591-601. 2002
    ....
  46. ncbi Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders
    Laura Mandelli
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Int J Neuropsychopharmacol 10:437-47. 2007
    ..Moreover, COMT was risk factor for onset of both major depression and bipolar disorder, in conjunction with adversities...
  47. ncbi Catechol O-methyltransferase (COMT) mRNA expression in the dorsolateral prefrontal cortex of patients with schizophrenia
    Mitsuyuki Matsumoto
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA
    Neuropsychopharmacology 28:1521-30. 2003
    ..The disease-related laminar difference of COMT expression may be involved in dysregulation of dopamine signaling circuits in the DLPFC of patients with schizophrenia...
  48. ncbi Catechol-O-methyltransferase Val-108/158-Met gene variants associated with performance on the Wisconsin Card Sorting Test
    Ridha Joober
    Arch Gen Psychiatry 59:662-3. 2002
  49. ncbi Lack of association of the COMT (Val158/108 Met) gene and schizophrenia: a meta-analysis of case-control studies
    M R Munafò
    Cancer Research UK GPRG, Department of Clinical Pharmacology, University of Oxford, Oxford, UK
    Mol Psychiatry 10:765-70. 2005
    ..The results of our meta-analysis do not support an association between the COMT Val allele and schizophrenia case status, and do not support recent claims that this association may be moderated by ancestry...
  50. ncbi Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum
    Leonid Yavich
    In Vivo Voltammetry Contract Research Laboratory and Department of Pharmacology and Toxicology, University of Kuopio, FIN 70211 Kuopio, Finland
    J Neurosci 27:10196-209. 2007
    ....
  51. ncbi Molecular modelling study of the mechanism of high-potency inhibition of human catechol-O-methyltransferase by (-)-epigallocatechin-3-O-gallate
    B T Zhu
    Department of Pharmacology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Xenobiotica 38:130-46. 2008
    ..It is concluded that the very tight binding interaction of EGCG with COMT makes it a potent non-competitive inhibitor, but its imperfect geometry makes it a poor substrate for methylation by this enzyme...
  52. ncbi CNS dopamine oxidation and catechol-O-methyltransferase: importance in the etiology, pharmacotherapy, and dietary prevention of Parkinson's disease
    Bao Ting Zhu
    Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA
    Int J Mol Med 13:343-53. 2004
    ..It is believed that these conceptual developments would also aid in our better understanding of other age-related neurodegenerative disorders, such as Alzheimer's and Huntington's diseases...
  53. ncbi Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure
    A G Nackley
    Center for Neurosensory Disorders, University of North Carolina, Chapel Hill, NC 27599, USA
    Science 314:1930-3. 2006
    ..These data highlight the functional significance of synonymous variations and suggest the importance of haplotypes over single-nucleotide polymorphisms for analysis of genetic variations...
  54. ncbi Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction
    Avshalom Caspi
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Biol Psychiatry 57:1117-27. 2005
    ..The vast majority of cannabis users do not develop psychosis, however, prompting us to hypothesize that some people are genetically vulnerable to the deleterious effects of cannabis...
  55. pmc Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in mice
    Francesco Papaleo
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:8709-23. 2008
    ..Our data indicate a critical role for the COMT gene in an apparent evolutionary trade-off between cognitive and affective functions...
  56. ncbi The COMT val158met polymorphism is associated with peak BMD in men
    Mattias Lorentzon
    Center for Bone Research at the Sahlgrenska Academy, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Bone Miner Res 19:2005-11. 2004
    ..The associations between the functional val158met polymorphism of the estrogen-degrading COMT enzyme and skeletal properties in young men were investigated. BMD was associated with COMT genotype...
  57. ncbi Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (-)-epigallocatechin gallate
    Hong Lu
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Drug Metab Dispos 31:572-9. 2003
    ..The present work provides basic information on the methylation of EGCG and suggests that EGCG may inhibit COMT-catalyzed methylation of endogenous and exogenous compounds...
  58. ncbi Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls
    J H Barnett
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Mol Psychiatry 12:502-9. 2007
    ..There was no evidence of publication bias. We conclude that there is small but significant relationship between Val(158)Met genotype and executive function in healthy individuals but not in schizophrenia...
  59. ncbi Higher scores of self reported schizotypy in healthy young males carrying the COMT high activity allele
    D Avramopoulos
    University Mental Health Research Institute, Argyrocastrou and Ionias St, Papagou, Athens 15669, Greece
    Mol Psychiatry 7:706-11. 2002
    ..This finding is in the same direction as reported findings on schizophrenia and it adds to the list of evidence that COMT or a nearby gene in linkage disequilibrium is involved in the pathogenesis of the disease...
  60. ncbi Improvement of prepulse inhibition and executive function by the COMT inhibitor tolcapone depends on COMT Val158Met polymorphism
    Stella G Giakoumaki
    Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, Greece
    Neuropsychopharmacology 33:3058-68. 2008
    ..These results suggest that early information processing and working memory may both depend on PFC DA signaling, and that they may both relate to PFC DA levels according to an inverted U-shaped curve function...
  61. ncbi No association between catechol-O-methyltransferase (COMT) gene polymorphism and attention deficit hyperactivity disorder (ADHD) in an Irish sample
    Z Hawi
    Department of Genetics and Psychiatry, Trinity College, Dublin, Ireland
    Am J Med Genet 96:282-4. 2000
    ..The absence of association between COMT alleles and ADHD indicated that this locus does not play a significant role or at least a role independent of other genes, in predisposing to ADHD in the Irish population...
  62. pmc Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder
    Hamid Mostafavi Abdolmaleky
    Department of Psychiatry at Massachusetts Mental Health Center and Harvard Institute of Psychiatric Epidemiology and Genetics, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 15:3132-45. 2006
    ....
  63. ncbi Impact of complex genetic variation in COMT on human brain function
    A Meyer-Lindenberg
    Unit for Systems Neuroscience in Psychiatry, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892 1257, USA
    Mol Psychiatry 11:867-77, 797. 2006
    ..This work provides an in vivo approach to functional validation in brain of the biological impact of complex genetic variations within a gene that may be critical for its clinical association...
  64. ncbi An association study of catechol-O-methyltransferase and monoamine oxidase A polymorphisms and personality traits in Koreans
    Se Joo Kim
    Department of Psychiatry, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Shinchon dong, Seodaemun gu, Seoul 120 752, South Korea
    Neurosci Lett 401:154-8. 2006
    ..These results suggest that genetic variants of the COMT Val158Met gene may play a role in HA in Korean females but not in males...
  65. pmc No evidence of association between Catechol-O-Methyltransferase (COMT) Val158Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study
    Sophie Mills
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, CF14 4XN, UK
    BMC Psychiatry 4:15. 2004
    ..Two studies showed that subjects with the low activity Met allele performed better on the Wisconsin Card Sorting Test (WCST) and another study found an effect on processing speed and attention...
  66. ncbi Site-specific cytosine methylation in S-COMT promoter in 31 brain regions with implications for studies involving schizophrenia
    Brenda C Murphy
    Molecular Genetics Unit, Department of Biology and Division of Medical Genetics, The University of Western Ontario, London, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 133:37-42. 2005
    ..The unique observation of a completely methylated cytosine 23 in one patient with SZ may have the potential to affect COMT mRNA transcription and gene activity, but remains to be evaluated...
  67. ncbi Changes in endogenous monoamines in aged rats
    J J Lee
    Department of General Surgery, Mackay Memorial Hospital, College of Medicine, National Cheng Kung University, Tainan City, Taiwan
    Clin Exp Pharmacol Physiol 28:285-9. 2001
    ..4. These data suggest that ageing may alter endogenous monoamines in both the brain and peripheral tissues...
  68. ncbi COMT (Val158Met) polymorphism is not associated to neuropathic pain in a Spanish population
    Pilar Armero
    Unidad de Medicina Molecular, Departamento de Medicina, Universidad de Salamanca, Spain
    Eur J Pain 9:229-32. 2005
    ..Our study concludes that functional Val158Met polymorphism of COMT gene is not associated to increased susceptibility to neuropathic pain...
  69. ncbi Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia
    Stanley Zammit
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 128:19-20. 2004
    ..These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior...
  70. ncbi The role of catechol-O-methyltransferase in the inactivation of catecholestrogen
    C R Creveling
    Cell Mol Neurobiol 23:289-91. 2003
  71. ncbi Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression
    R E Straub
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, NIH, US Department of Health and Human Services, Bethesda, MD 20892 1379, USA
    Mol Psychiatry 12:854-69. 2007
    ..These coincident results implicate GAD1 in the etiology of schizophrenia and suggest that the mechanism involves altered cortical GABA inhibitory activity, perhaps modulated by dopaminergic function...
  72. pmc Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior
    J A Gogos
    The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 95:9991-6. 1998
    ....
  73. pmc Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors
    Andrea Gail Nackley
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    Pain 128:199-208. 2007
    ....
  74. pmc Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning
    Michael J Frank
    Department of Psychology and Program in Neuroscience, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 104:16311-6. 2007
    ..Computational maximum likelihood analyses reveal independent gene effects on three reinforcement learning parameters that can explain the observed dissociations...
  75. pmc A highly significant association between a COMT haplotype and schizophrenia
    Sagiv Shifman
    Institute of Life Sciences, The Hebrew University of Jerusalem, Israel
    Am J Hum Genet 71:1296-302. 2002
    ..We found a highly significant association between schizophrenia and a COMT haplotype (P=9.5x10-8). The approach presented can be widely implemented for the genetic dissection of other common diseases...
  76. pmc Assessing the molecular genetics of attention networks
    John Fossella
    Sackler Institute of Developmental Psychobiology, Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    BMC Neurosci 3:14. 2002
    ..g. attention) have been shown to be related to several anatomical networks. Recently, we have developed an Attention Network Test (ANT) that provides a separate measure for each of three anatomically defined attention networks...
  77. ncbi Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia
    Robert M Bilder
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Biol Psychiatry 52:701-7. 2002
    ....
  78. ncbi Genes and the parsing of cognitive processes
    Terry E Goldberg
    Clinical Brain Disorders Branch, GCAPP, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Trends Cogn Sci 8:325-35. 2004
    ..As such it may be necessary to view cognition in novel ways, based on constraints imposed by genomics and neurobiology, in order to increase the effect size of genotypic influences on cognition...
  79. ncbi Obesity is associated with genetic variants that alter dopamine availability
    A C Need
    Department of Biology, University College London, The Darwin Building, Gower Street, London WC1E 6BT
    Ann Hum Genet 70:293-303. 2006
    ..It is therefore a priority to assess the associations in replication datasets...
  80. ncbi Genomic organization of the human catechol O-methyltransferase gene and its expression from two distinct promoters
    J Tenhunen
    Orion Corporation, Orion Farmos, Research Center, Helsinki, Finland
    Eur J Biochem 223:1049-59. 1994
    ..5-kb transcript, suggesting that it controls the expression of this MB-mRNA. Similarities between the rat and human COMT gene promoters are analyzed...
  81. ncbi Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli
    Luda Diatchenko
    Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, NC, USA
    Pain 125:216-24. 2006
    ..Here, we propose a mechanism whereby these two genetic polymorphisms differentially affect pain perception...
  82. ncbi Catechol O-methyltransferase genetic polymorphism in panic disorder
    Jong Min Woo
    Department of Neuropsychiatry, Seoul Paik Hospital, Inje University, Seoul, Korea
    Am J Psychiatry 159:1785-7. 2002
    ..The authors examined the distribution of catechol O-methyltransferase (COMT) genotypes in patients with panic disorder as well as the relationship between a COMT polymorphism and the clinical characteristics of these patients...
  83. ncbi Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women
    Katharina Domschke
    Department of Psychiatry, University of Munster, Germany
    Int J Neuropsychopharmacol 7:183-8. 2004
    ..Our data support a role of the 472G/A (V158M) COMT polymorphism or a nearby locus in the pathogenesis of panic disorder in women...
  84. pmc Association of catechol-O-methyltransferase with smoking cessation in two independent studies of women
    Susan Colilla
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacogenet Genomics 15:393-8. 2005
    ..To determine if the lower activity Met allele of COMT was associated with smoking cessation in women, we used two independent studies: a population-based case--control study and a nicotine replacement clinical trial...
  85. ncbi Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease
    R A Sweet
    Division of Geriatrics and Neuropsychiatry, Department of Psychiatry, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 10:1026-36. 2005
    ..Examination of variation at ERE6 in subjects with schizophrenia, and further examination of the independent and additive effects of variations in COMT on gene expression, is warranted...
  86. ncbi Association of COMT Val108/158Met genotype with smoking cessation
    Marcus R Munafo
    Department of Experimental Psychology, University of Bristol, UK
    Pharmacogenet Genomics 18:121-8. 2008
    ..We also investigated the association of the COMT genotype with withdrawal and mood symptoms, to identify possible mediating mechanisms by which the COMT genotype might influence response to NRT...
  87. ncbi Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS
    Elena Michaelovsky
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Int J Neuropsychopharmacol 11:351-63. 2008
    ..2DS and supports the hypothesis that COMT gene variations contribute to genetic predisposition to psychiatric disorders in the general population...
  88. ncbi Catechol-o-methyltransferase polymorphism and susceptibility to major depressive disorder modulates psychological stress response
    Mbemba Jabbi
    Departments of Psychiatry, University Medical Center Groningen, UMCG dBCN NeuroImaging Center, Groningen, Netherlands
    Psychiatr Genet 17:183-93. 2007
    ..Little, however, is known about the genetic influence on the endocrine and behavioural stress response in relation to MDD...
  89. ncbi Family-based and case-control association studies of catechol-O-methyltransferase in attention deficit hyperactivity disorder suggest genetic sexual dimorphism
    Qiujin Qian
    Institute of Mental Health, Peking University, Beijing 100083, People s Republic of China
    Am J Med Genet B Neuropsychiatr Genet 118:103-9. 2003
    ..Although these results suggest the COMT gene exerts some influence on the risk for ADHD in the Han Chinese population, given the potential for Type I error, these findings require replication before drawing definitive conclusions...
  90. ncbi Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations
    Joke Beuten
    Program in Genomics and Bioinformatics on Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA
    Neuropsychopharmacology 31:675-84. 2006
    ..In summary, our results provide evidence for a role of COMT in the susceptibility to ND and further confirm that its effect is ethnic and gender specific...
  91. ncbi The molecular genetics of cognition: dopamine, COMT and BDNF
    J Savitz
    MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Genes Brain Behav 5:311-28. 2006
    ..The implications of molecular genetic cognitive research for psychiatry are discussed in light of these data...
  92. ncbi Association between catechol-O-methyltransferase functional polymorphism and male suicide completers
    Hisae Ono
    Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Faculty of Medical Sciences, Kobe University Graduate School of Medicine, Kobe, Japan
    Neuropsychopharmacology 29:1374-7. 2004
    ..52; 95% CL: 0.31-0.89; p=0.016). However, this was not the case in females. Our results suggest that the Val/Val genotype is a protective factor against suicide in males...
  93. ncbi Val/Met polymorphism of the COMT gene moderates the association between job strain and early atherosclerosis in young men
    Mirka Hintsanen
    Department of Psychology, University of Helsinki, Helsinki, Finland
    J Occup Environ Med 50:649-57. 2008
    ..COMT gene influences dopamine transmission and dopaminergic activity might moderate effects of stress on CHD risk. We examine whether COMT Val158Met polymorphism moderates the association between job strain and atherosclerosis...
  94. ncbi Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder
    Alessandro Rotondo
    Department of Psychiatry, University of Pisa, Italy
    Am J Psychiatry 159:23-9. 2002
    ....
  95. ncbi Association between the dopamine D2 receptor TaqI A2 allele and low activity COMT allele with obsessive-compulsive disorder in males
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 16:446-50. 2006
    ..Mounting evidence suggests the involvement of the dopamine system in the pathophysiology of obsessive-compulsive disorder...
  96. ncbi Catechol-O-methyltransferase polymorphism (COMT) in suicide attempters: a possible gender effect on anger traits
    Patrick Baud
    Department of Psychiatry, University Hospital of Geneva, Geneva, Switzerland
    Am J Med Genet B Neuropsychiatr Genet 144:1042-7. 2007
    ..These results are discussed in the light of recently published data on the effect of COMT Val158Met polymorphism on different cognitive and behavioral traits...
  97. ncbi COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance
    Katherine E Burdick
    Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Bipolar Disord 9:370-6. 2007
    ..A large body of evidence suggests that COMT is associated with cognitive performance in patients with schizophrenia and in healthy volunteers but there have been no reports of its relationship to cognition in BPD...
  98. pmc The association between headache and Val158Met polymorphism in the catechol-O-methyltransferase gene: the HUNT Study
    Knut Hagen
    Department of Clinical Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Headache Pain 7:70-4. 2006
    ..2% vs. 33.6%, p = 0.04). That non-migrainous headache was less likely among women with the Val/Val genotype may be an incidental finding, but should be investigated in further studies...
  99. ncbi Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study
    I Massat
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Belgium
    Mol Psychiatry 10:598-605. 2005
    ..The COMT gene may have complex and pleiotropic effects on susceptibility and symptomatology of neuropsychiatric disorders...
  100. ncbi Estrogen-metabolizing gene COMT polymorphism synergistic APOE epsilon4 allele increases the risk of Alzheimer disease
    P N Wang
    The Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Dement Geriatr Cogn Disord 19:120-5. 2005
    ..004. It is possible that a high metabolism of estrogen by COMT may have reduced the protective effect of estrogen in AD. Further studies to clarify this interaction may improve our understanding of the generic risks for AD...
  101. pmc Catechol-O-methyltransferase (COMT) Val108/158 Met polymorphism does not modulate executive function in children with ADHD
    Evan Taerk
    Department of Psychiatry, McGill University and Douglas Hospital Research Centre, Montreal, Quebec, H4H 1R3, Canada
    BMC Med Genet 5:30. 2004
    ....

Research Grants62

  1. COMT Genotype and Risky Decision Making in HIV and Methamphetamine Dependence
    Mariana Cherner; Fiscal Year: 2010
    ..Findings will add to the understanding of individual differences in response to risk-reduction interventions and have the potential to inform the tailoring of future interventions. ..
  2. Green Tea and Reduction of Breast Cancer Risk
    MINDY SUSAN KURZER; Fiscal Year: 2013
    ..The development of a viable non-toxic chemoprevention strategy targeting high risk women could have a significant impact on breast cancer morbidity and mortality. ..
  3. Non-Hodgkin lymphoma in women: reproductive, hormonal and genetic factors
    Paige M Bracci; Fiscal Year: 2011
    ....
  4. Combined use of green tea and quercetin in prostate cancer
    SUSANNE MARGARETE HENNING; Fiscal Year: 2012
    ..This novel treatment will retain the non-toxic character of green tea and at the same time increase its activity in chemoprevention of CaP. ..
  5. Metal Exposure and Children?s Preschool Neurodevelopment
    David C Bellinger; Fiscal Year: 2012
    ..The effects of exposures to combinations of metals, including lead, is also a major focus. This more closely mirrors "real world" exposures, which invariably involve a mixture of compounds rather than a single compound. ..
  6. Understanding the Role of COMT Variants in Sensorimotor Gating
    XIANJIN ZHOU; Fiscal Year: 2010
    ..abstract_text> ..
  7. Polymorphisms of estrogen-metabolizing genes in kidney cancer
    Yuichiro Tanaka; Fiscal Year: 2013
    ..Such information can lead to the identification of Veterans with higher risk for RCC. Proposed research may also lead to implications for possible therapy for RCC. ..
  8. Quercetin to enhance the bioavailability and activity of green tea polyphenols
    SUSANNE MARGARETE HENNING; Fiscal Year: 2013
    ..The results will lay the foundation for future clinical trials to evaluate the interaction of quercetin and GT in chemoprevention of early stages of prostate cancer. ..
  9. Persistent COMT-dependent Pain: Role of beta-adrenergic Receptors
    ANDREA G NACKLEY NEELY; Fiscal Year: 2013
    ..g., beta2- and beta3ARs) for development of effective therapies for patients with persistent pain conditions.]] ..
  10. Genetic by Context Influence on Trajectories of Adolescent Health Risk Behaviors
    Vangie A Foshee; Fiscal Year: 2010
    ....
  11. Identifying Genetic Risk for Maternal Insensitivity and Infant Dysregulation
    Esther M Leerkes; Fiscal Year: 2013
    ....
  12. NEUROCOGNITIVE EFFECTS OF NICOTINE DEPRIVATION AND DOPAMINE GENES
    Andrey P Anokhin; Fiscal Year: 2010
    ..A better understanding of the genetic and neurobiological factors contributing to smoking relapse can suggest new targets for behavioral and pharmacological treatment, which can ultimately lead to improved rates of successful quitting. ..
  13. Genes and Alterations in Brain Structure and Function in Depression
    Warren D Taylor; Fiscal Year: 2012
    ..This study will advance our understanding of how genes affect the brain, which in turn will provide important information on the causes of depression. ..
  14. Self-Regulation Failure: Identifying and Modifying a Risk Phenotype
    Timothy J Strauman; Fiscal Year: 2012
    ..Based on this model, we anticipate that the theory- based brief change techniques will prove efficacious and will ultimately provide a basis for effective broader-scale therapeutic and preventive interventions in future studies. ..
  15. Genes, Brain, and Behavior in Human Aggression
    Nelly Alia-Klein; Fiscal Year: 2013
    ..Therefore, understanding the basic genetic, neurochemical and neuroanatomical processes associated with aggression is a public health concern. ..
  16. Longitudinal Population-Based Study of Vulvodynia
    Barbara D Reed; Fiscal Year: 2012
    ....
  17. First-Episode Psychosis and Pre-Onset Cannabis Use
    Michael T Compton; Fiscal Year: 2012
    ....
  18. Dopaminergic variants involved in smoking behavior: A perfusion fMRI study
    Teresa R Franklin; Fiscal Year: 2010
    ..Ultimately, if a brain/behavioral/genetic endophenotype can be determined in advance of treatment, smoking cessation treatments can be structured to meet individual needs. ..
  19. The Influence of Dopaminergic Genetic Variants on D2-like Receptors in Drinkers
    Amira K Brown; Fiscal Year: 2011
    ....
  20. Effect of COMT genetic polymorphism on response to propranolol therapy in TMD
    INNA EVGENIEVNA TCHIVILEVA; Fiscal Year: 2012
    ..Evaluation of propranolol efficacy for TMD therapy and identification of genetic predictors of the outcome of propranolol therapy will apply recent advances in genetic research to clinical practice. ..
  21. Improving Outcome in Neonatal Abstinence Syndrome
    Barry M Lester; Fiscal Year: 2013
    ....
  22. Variability in Brain Function Underlying Motivated Behavior in Adolescence
    Beatriz Luna; Fiscal Year: 2013
    ....
  23. In Vivo Detection of Neuronal Activity
    Russell E Jacobs; Fiscal Year: 2010
    ..abstract_text> ..
  24. Nicotine Abstinence-Induced Cognitive Alterations by COMT Genotype
    James Loughead; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: This study will improve our understanding of individual differences in cognitive deficits that arise during abstinence from smoking and predict relapse. ..
  25. Dopaminergic Neurons from Pluripotent Stem Cells for Substance Abuse Research
    Pietro P Sanna; Fiscal Year: 2012
    ..abstract_text> ..
  26. Effect of COMT Genotype on Functional Organization During Working Memory and Rest
    Evan M Gordon; Fiscal Year: 2012
    ..Importantly, the integrity of the task-negative network predicts healthy attentional control and is disrupted in Schizophrenia, a disorder with working memory dysfunction whose pathogenesis involves COMT. ..
  27. Dopaminergic Modulation of Immediate Reward Bias
    MARY K KELM; Fiscal Year: 2012
    ..Because immediate reward bias is a characteristic of alcohol-dependent individuals, these results could lead to the development of novel supportive therapies and improved treatment outcomes for people seeking abstinence. ..
  28. Neurobiologic Mechanisms of Cognitive Dysfunction and Decline in Medulloblastoma
    Shelli R Kesler; Fiscal Year: 2013
    ..The research proposed here also will contribute more broadly to a better understanding of how early cancer- related brain injury affects brain development and neural organization in humans. ..
  29. Genetic Influences on Human Neuroanatomical Shapes
    Arthur W Toga; Fiscal Year: 2013
    ..The activities in the project are extremely responsive to the NIH's mission in advancing GWAS to identify common genetic factors that influence health and disease. ..
  30. SIGNIFICANCE OF GENETIC VARIATION IN ESTROGEN METABOLISM
    David Eaton; Fiscal Year: 2001
    ..abstract_text> ..
  31. Working Memory Performance among Childhood Brain Tumor Survivors
    HEATHER CONKLIN; Fiscal Year: 2009
    ....
  32. NEUROBIOLOGY OF CANNABIS EFFECTS
    DEEPAK D SOUZA; Fiscal Year: 2009
    ....
  33. L-DOPA OVERLOAD: MECHANISMS FOR THE SIDE EFFECTS.
    CLIVEL GEORGE CHARLTON; Fiscal Year: 2010
    ..abstract_text> ..
  34. Understanding the Role of COMT Variants in Sensorimotor Gating
    Victoria Risbrough; Fiscal Year: 2009
    ..abstract_text> ..
  35. CATECHOL-O-METHYLTRANSFERASE: BIOCHEMISTRY AND GENETICS
    Mark Grossman; Fiscal Year: 1991
    ....
  36. Role of methylation in prevention the toxicity of epigallocatechin-3-gallate
    JOSHUA LAMBERT; Fiscal Year: 2007
    ..Finally, methodologies developed during this proposal will be useful in monitoring safety in human intervention studies of EGCG. [unreadable] [unreadable] [unreadable]..
  37. STRUCTURAL ANALOGS OF S-ADENOSYLMETHIONINE
    RONALD BORCHARDT; Fiscal Year: 1980
    ..By evaluation of the SAH analogs prepared in our studies as inhibitors of these methyltransferase systems, it is hoped that differences in inhibitory specificity will be detected which can be used to design enzyme specific inhibitors. ..
  38. Catechol-o-Methyltansferase and Breast Cancer
    JAMES YAGER; Fiscal Year: 2007
    ....
  39. ADRENERGIC VASOREGULATORY INTERACTIONS IN HYPERTENSION
    Richard Weinshilboum; Fiscal Year: 1980
    ....
  40. Optimizing the Use of Morphine in Preterm Infants
    John van den Anker; Fiscal Year: 2009
    ..To develop a population PK/PD model of morphine dosing based on gestational age, postnatal age, glomerular filtration rate, and genetic variability in the UGT2B7, mu-opioid receptor and COMT genes. ..
  41. Roles of polymorphic COMT, tea polyphenols and proteasome in cancer prevention
    QING PING DOU; Fiscal Year: 2010
    ..abstract_text> ..
  42. ENDOMETRIAL CANCER AND CYP1A1, GSTM1 AND POLYMORPHISMS
    Noel Weiss; Fiscal Year: 1999
    ..Additionally, this information potentially could be used to predict a woman's sensitivity to the carcinogenic effects of HRT, and thus bear on a woman's decision regarding long-term use of HRT. ..
  43. Individual Differences in Extrastriatal DA Release
    David Zald; Fiscal Year: 2009
    ..abstract_text> ..
  44. MAMMARY ESTROGEN METABOLISM AND BREAST CANCER RISK
    Fritz Parl; Fiscal Year: 2004
    ..The applicants will measure catechol estrogens in tissues selected by genotype and matched by menopausal status and body mass index and compare the results to those in their in vitro and cell line experiments. ..
  45. Domain Generality of Conflict Resolution Mechanisms
    Ranjani Prabhakaran; Fiscal Year: 2009
    ..A greater understanding of the role of prefrontal cortex and the nature of the processing mechanisms involved in mediating conflict resolution across a variety of contexts could better inform treatment strategies for patients. ..
  46. VASOACTIVE AMINE DISPOSITION IN CULTURED ENDOTHELIUM
    JEROME ROTH; Fiscal Year: 1980
    ..Recently we have been successful in propagating a pure primary line of endothelial cells. This was accomplished by using two new growth factors, Endothelial Cell Growth Supplement (ECGS) and Human Fibronectin (HFN). ..
  47. Genetic Associations with Biased Processing of Emotion Cues in MDD
    CHRISTOPHER BEEVERS; Fiscal Year: 2009
    ..Thus, the proposed study should advance our knowledge of the etiological and maintenance processes for MDD and provide specific direction for the design of treatment programs for this serious psychiatric problem. ..
  48. PET STUDIES OF CATECHOL-O-METHYLTRANSFERASE
    Yu Shin Ding; Fiscal Year: 2000
    ..The proposed studies will provide the first functional maps of COMT in the primate, thus affording a scientific tool for the investigation of COMT in living systems along with potential applications to drug development and oncology. ..
  49. Genetic Determinants of COMT Expression
    Steven Hamilton; Fiscal Year: 2007
    ..This in vitro work may be useful for the understanding of the genetic contribution of COMT to disease susceptibility, particularly with regard to the cis regulation of the COMT locus. [unreadable] [unreadable] [unreadable]..
  50. BETA-RECEPTOR & MEMBRANE CATECHOL-O-METHYLTRANSFERASE
    SIMEON WRENN; Fiscal Year: 1980
    ....
  51. FIBROBLAST MONOAMINE METABOLISM AND PSYCHOSES
    Earl Giller; Fiscal Year: 1980
    ..Also, platelet MAO and red blood cell COMT activities were not correlated with fibroblast activities of these enzymes. MAO activity was similar in fibroblast lines from manic-depressives and controls...
  52. GENOME-WIDE ANALYSIS FOR ADDICTION SUSCEPTIBILITY GENES
    Herbert Lachman; Fiscal Year: 2005
    ..By the end of the project, which will coincide with the completion of the human genome project, they will be able to analyze all of the specific candidate genes that map to linked markers. ..
  53. DOUBLE-BLIND CONTROLLED TRIAL OF NIGRAL GRAFTING IN PD
    C Olanow; Fiscal Year: 2003
    ..abstract_text> ..
  54. MOLECULAR ORIGIN OF CANCER--CATECHOL/SEMIQUINOE/QUINONE
    Ercole Cavalieri; Fiscal Year: 2003
    ..In addition, we will identify biomarkers for use in diagnosis and in studies of prevention of breast cancer and other diseases. ..
  55. Molecular Orgin Cancer--Catechol Estrogen 3 4 Quinones
    Ercole Cavalieri; Fiscal Year: 2004
    ..The knowledge acquired from these studies will be essential for developing preventive strategies. ..
  56. Dietary Polyphenols Are Consequential Epigenetic Modulators of Gene Expression
    BAOTING ZHU; Fiscal Year: 2009
    ..It is expected that the outcomes of the proposed studies will have direct clinical utility in the near future and far-reaching human health implications. ..
  57. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
  58. Genetic Bases of Developmental Language Disorders
    Elena L Grigorenko; Fiscal Year: 2010
    ..abstract_text> ..
  59. Polymorphisms and Haplotypes in the IGF Pathway and Endometrial Cancer Risk
    Monica McGrath; Fiscal Year: 2007
    ..We will have > 85% power to detect a relative risk 1.50 or greater for the main effects of most of the genotypes and haplotypes of interest. [unreadable] [unreadable] [unreadable]..
  60. SULFATE CONJUGATION AND DRUG METABOLISM
    Richard Weinshilboum; Fiscal Year: 2007
    ....