galactosyltransferases

Summary

Summary: Enzymes that catalyze the transfer of galactose from a nucleoside diphosphate galactose to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.

Top Publications

  1. ncbi The molecular basis for galalpha(1,3)gal expression in animals with a deletion of the alpha1,3galactosyltransferase gene
    Julie Milland
    The Austin Research Institute, Austin Health, Heidelberg, Australia
    J Immunol 176:2448-54. 2006
  2. pmc Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases
    Belinda Schegg
    Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Mol Cell Biol 29:943-52. 2009
  3. pmc A unique beta1,3-galactosyltransferase is indispensable for the biosynthesis of N-glycans containing Lewis a structures in Arabidopsis thaliana
    Richard Strasser
    Institute of Applied Genetics and Cell Biology, BOKU, University of Natural Resources and Applied Life Sciences, A 1190 Viena, Austria
    Plant Cell 19:2278-92. 2007
  4. ncbi Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience
    Kenji Kuwaki
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, MGH East, 13th Street, Boston, Massachusetts 02129, USA
    Nat Med 11:29-31. 2005
  5. pmc Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice
    Jianxin Fu
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    J Clin Invest 121:1657-66. 2011
  6. pmc IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1
    Hitoshi Suzuki
    University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Clin Invest 118:629-39. 2008
  7. pmc Galactinol synthase1. A novel heat shock factor target gene responsible for heat-induced synthesis of raffinose family oligosaccharides in Arabidopsis
    Tressa Jacob Panikulangara
    Zentrum für Molekularbiologie der Pflanzen, Allgemeine Genetik, Universitat Tubingen, D 72076 Tubingen, Germany
    Plant Physiol 136:3148-58. 2004
  8. pmc Production of alpha 1,3-galactosyltransferase-deficient pigs
    Carol J Phelps
    PPL Therapeutics Inc, 1700 Kraft Drive, Blacksburg, VA 24060, USA
    Science 299:411-4. 2003
  9. ncbi Analysis of the human cancer glycome identifies a novel group of tumor-associated N-acetylglucosamine glycan antigens
    Tero Satomaa
    Glykos Finland Ltd, Helsinki, Finland
    Cancer Res 69:5811-9. 2009
  10. pmc Analysis of the raffinose family oligosaccharide pathway in pea seeds with contrasting carbohydrate composition
    T Peterbauer
    Chemical Physiology of Plants, Institute of Ecology, University of Vienna, A-1090 Vienna, Austria
    Plant Physiol 127:1764-72. 2001

Research Grants

Detail Information

Publications227 found, 100 shown here

  1. ncbi The molecular basis for galalpha(1,3)gal expression in animals with a deletion of the alpha1,3galactosyltransferase gene
    Julie Milland
    The Austin Research Institute, Austin Health, Heidelberg, Australia
    J Immunol 176:2448-54. 2006
    ..Galalpha(1,3)Gal synthesized by iGb3S may affect survival of pig transplants in humans, and deletion of this gene, or modification of its product, warrants consideration...
  2. pmc Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases
    Belinda Schegg
    Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Mol Cell Biol 29:943-52. 2009
    ..We have identified two collagen galactosyltransferases using affinity chromatography and tandem mass spectrometry protein sequencing...
  3. pmc A unique beta1,3-galactosyltransferase is indispensable for the biosynthesis of N-glycans containing Lewis a structures in Arabidopsis thaliana
    Richard Strasser
    Institute of Applied Genetics and Cell Biology, BOKU, University of Natural Resources and Applied Life Sciences, A 1190 Viena, Austria
    Plant Cell 19:2278-92. 2007
    ....
  4. ncbi Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience
    Kenji Kuwaki
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, MGH East, 13th Street, Boston, Massachusetts 02129, USA
    Nat Med 11:29-31. 2005
    ..There were no infectious complications directly related to the immunosuppressive regimen. The transplantation of hearts from GalT-KO pigs increased graft survival over previous studies...
  5. pmc Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice
    Jianxin Fu
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    J Clin Invest 121:1657-66. 2011
    ..These data suggest what we believe to be a new molecular mechanism for the pathogenesis of UC...
  6. pmc IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1
    Hitoshi Suzuki
    University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Clin Invest 118:629-39. 2008
    ..Thus, our data suggest that premature sialylation likely contributes to the aberrant IgA1 glycosylation in IgA nephropathy and may represent a new therapeutic target...
  7. pmc Galactinol synthase1. A novel heat shock factor target gene responsible for heat-induced synthesis of raffinose family oligosaccharides in Arabidopsis
    Tressa Jacob Panikulangara
    Zentrum für Molekularbiologie der Pflanzen, Allgemeine Genetik, Universitat Tubingen, D 72076 Tubingen, Germany
    Plant Physiol 136:3148-58. 2004
    ..The biological function of this osmoprotective substance and the role of HSF-dependent genes in this biochemical pathway are discussed...
  8. pmc Production of alpha 1,3-galactosyltransferase-deficient pigs
    Carol J Phelps
    PPL Therapeutics Inc, 1700 Kraft Drive, Blacksburg, VA 24060, USA
    Science 299:411-4. 2003
    ....
  9. ncbi Analysis of the human cancer glycome identifies a novel group of tumor-associated N-acetylglucosamine glycan antigens
    Tero Satomaa
    Glykos Finland Ltd, Helsinki, Finland
    Cancer Res 69:5811-9. 2009
    ..In conclusion, the identified terminal GlcNAc glycans should be recognized as a novel class of tumor markers...
  10. pmc Analysis of the raffinose family oligosaccharide pathway in pea seeds with contrasting carbohydrate composition
    T Peterbauer
    Chemical Physiology of Plants, Institute of Ecology, University of Vienna, A-1090 Vienna, Austria
    Plant Physiol 127:1764-72. 2001
    Raffinose family oligosaccharides (RFOs) are synthesized by a set of galactosyltransferases, which sequentially add galactose units from galactinol to sucrose...
  11. ncbi Down-regulation of beta1,4GalT V at protein level contributes to arsenic trioxide-induced glioma cell apoptosis
    Yuanyan Wei
    Key Laboratory of Glycoconjuates Research, Ministry of Public Health and Gene Research Center, Shanghai Medical College of Fudan University, Shanghai 200032, People s Republic of China
    Cancer Lett 267:96-105. 2008
    ....
  12. pmc Identification and characterization of in vitro galactosyltransferase activities involved in arabinogalactan-protein glycosylation in tobacco and Arabidopsis
    Yan Liang
    Department of Environmental and Plant Biology, Ohio University, Athens, Ohio 45701 2979, USA
    Plant Physiol 154:632-42. 2010
    ....
  13. pmc Association of cell surface mucins with galectin-3 contributes to the ocular surface epithelial barrier
    PABLO ARGUESO
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    J Biol Chem 284:23037-45. 2009
    ..Taken together, these results suggest that galectin-3 plays a key role in maintaining mucosal barrier function through carbohydrate-dependent interactions with cell surface mucins...
  14. ncbi Plant glycosyltransferases
    K Keegstra
    MSU DOE Plant Research Laboratory and Department of Biochemistry, Michigan State University, 48824, East Lansing, Michigan USA
    Curr Opin Plant Biol 4:219-24. 2001
    ..Moreover, analysis of the recently completed Arabidopsis genome sequence indicates the existence of several hundred additional genes encoding putative glycosyltransferases...
  15. ncbi Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability
    T Coetzee
    UNC Neuroscience Center, University of North Carolina at Chapel Hill 27599, USA
    Cell 86:209-19. 1996
    ..These results indicate that GalC and sulfatide play important roles in myelin function and stability...
  16. ncbi Cloning and expression of human core 1 beta1,3-galactosyltransferase
    Tongzhong Ju
    W K Warren Medical Research Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 277:178-86. 2002
    ..The core 1 beta3-Gal-T sequence has minimal homology with conserved sequences found in previously described beta3-galactosyltransferases, suggesting this enzyme is only distantly related to the known beta3-galactosyltransferase family.
  17. ncbi Type-B monogalactosyldiacylglycerol synthases are involved in phosphate starvation-induced lipid remodeling, and are crucial for low-phosphate adaptation
    Koichi Kobayashi
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 B 65 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    Plant J 57:322-31. 2009
    ..The widespread distribution of type-B MGD genes in land plants suggests that membrane lipid remodeling mediated by type-B MGD enzymes is a potent adaptation to Pi deficiency for land plants...
  18. pmc Two types of MGDG synthase genes, found widely in both 16:3 and 18:3 plants, differentially mediate galactolipid syntheses in photosynthetic and nonphotosynthetic tissues in Arabidopsis thaliana
    K Awai
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama, Kanagawa 226 8501, Japan
    Proc Natl Acad Sci U S A 98:10960-5. 2001
    ..e., in inflorescence (atMGD2) and roots (atMGD3), where they conceivably influence the eukaryotic structure prominence in MGDG. In addition, their expression of type B enzymes is enhanced under phosphate deprivation...
  19. ncbi Myelin galactolipids are essential for proper node of Ranvier formation in the CNS
    J L Dupree
    Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci 18:1642-9. 1998
    ..Taken together, the data presented here indicate that GalC and sulfatide are essential in proper CNS node and paranode formation and that these lipids are important in ensuring proper axo-oligodendrocyte interactions...
  20. pmc Down-regulation of core 1 beta1,3-galactosyltransferase and Cosmc by Th2 cytokine alters O-glycosylation of IgA1
    Koshi Yamada
    Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan
    Nephrol Dial Transplant 25:3890-7. 2010
    ....
  21. pmc Mouse fertility is enhanced by oocyte-specific loss of core 1-derived O-glycans
    Suzannah A Williams
    Department of Cell Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    FASEB J 22:2273-84. 2008
    ..These results identify novel roles for glycoproteins from the oocyte as suppressors of fertility and regulators of follicular integrity in the mouse...
  22. ncbi Differential gene expression of beta-1,4-galactosyltransferases I, II and V during mouse brain development
    N Nakamura
    Department of Biosignal Research, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Neurochem 76:29-38. 2001
    ..The differential gene expression of beta-1,4-GalTs I, II and V during mouse brain development could affect the differential galactosylation of brain glycoproteins, as revealed by lectin blot analysis...
  23. ncbi Down-regulation of the epidermal growth factor receptor by altering N-glycosylation: emerging role of β1,4-galactosyltransferases
    Hans J Gabius
    Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Veterinarstr 13, D 80539 Munich, Germany
    Anticancer Res 32:1565-72. 2012
    ..Blocking N-glycosylation of the epidermal growth factor receptor (EGFR) by tunicamycin inhibits its cellular accumulation. Due to the toxic potential of this drug, finding less drastic routes to reduce EGFR expression is desirable...
  24. pmc The innate immune response and activation of coagulation in alpha1,3-galactosyltransferase gene-knockout xenograft recipients
    Mohamed Ezzelarab
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, PA 15261, USA
    Transplantation 87:805-12. 2009
    ..The role of the innate immune system in the development of thrombotic microangiopathy (TM) after alpha1,3-galactosyltransferase gene-knockout (GTKO) pig organ transplantation in primates is uncertain...
  25. ncbi Lactosylceramide mediates shear-induced endothelial superoxide production and intercellular adhesion molecule-1 expression
    L H Yeh
    Vascular Bioengineering Laboratory, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Vasc Res 38:551-9. 2001
    ..and O2(-.) mediates the shear-induced increase in ICAM-1 expression. Thus, LacCer may play an important role in hemodynamic force-induced pathological conditions, such as atherosclerosis and ischemia/reperfusion injury...
  26. ncbi A novel missense mutation in the galactosyltransferase-I (B4GALT7) gene in a family exhibiting facioskeletal anomalies and Ehlers-Danlos syndrome resembling the progeroid type
    Muhammad Faiyaz-Ul-Haque
    Program in Genetics and Genomic Biology, Department of Genetics, The Hospital for Sick Children, 9th Floor Elm Wing, Rm 9115, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Am J Med Genet A 128:39-45. 2004
    ....
  27. pmc Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis
    Jillian R Brown
    Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 284:4952-9. 2009
    ..These data suggest that nonsubstrate disaccharides have therapeutic potential through their ability to bind to glycosyltransferases in vivo and to alter glycan-dependent pathologic processes...
  28. ncbi Impact of thrombocytopenia on survival of baboons with genetically modified pig liver transplants: clinical relevance
    B Ekser
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Transplant 10:273-85. 2010
    ..If this problem can be resolved, we would anticipate that a pig liver could provide a period during which a patient in liver failure could be successfully bridged to allotransplantation...
  29. pmc Role of a single amino acid in the evolution of glycans of invertebrates and vertebrates
    Boopathy Ramakrishnan
    Structural Glycobiology Section, CCR Nanobiology Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    J Mol Biol 365:570-6. 2007
    ..Subsequently, the pre-existing alpha-LA-binding site was utilized during mammalian evolution to synthesize lactose in the mammary gland during lactation...
  30. ncbi In vitro investigation of pig cells for resistance to human antibody-mediated rejection
    Hidetaka Hara
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transpl Int 21:1163-74. 2008
    ..Organs from GTKO/CD46 pigs are likely to be significantly less susceptible to CDC...
  31. pmc Development of immunoglobulin A nephropathy- like disease in beta-1,4-galactosyltransferase-I-deficient mice
    Toshikazu Nishie
    Division of Transgenic Animal Science, Advanced Science Research Center, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Am J Pathol 170:447-56. 2007
    ..We propose that carbohydrates of serum IgA are involved in the development of IgAN, whether the carbohydrates are O-glycans or N-glycans...
  32. ncbi Impaired selectin-ligand biosynthesis and reduced inflammatory responses in beta-1,4-galactosyltransferase-I-deficient mice
    Masahide Asano
    Department of Transgenic Animal Science, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8640, Japan
    Blood 102:1678-85. 2003
    ....
  33. ncbi Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue
    Kazuhiko Yamada
    Transplantation Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    Nat Med 11:32-4. 2005
    ..We have achieved life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels...
  34. ncbi Frameshift and nonsense mutations in a human genomic sequence homologous to a murine UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase cDNA
    R D Larsen
    Howard Hughes Medical Institute, Ann Arbor, Michigan 48109 0650
    J Biol Chem 265:7055-61. 1990
    ..We therefore propose that this human sequence represents a pseudogene and cannot determine expression of Gal alpha 1----3Gal epitopes on human cells...
  35. ncbi Crystal structure of lactose synthase reveals a large conformational change in its catalytic component, the beta1,4-galactosyltransferase-I
    B Ramakrishnan
    Structural Glycobiology Section, Intramural Research Support Program SAIC, Laboratory of Experimental and Computational Biology, CCR, NCI, Frederick, MD 21702, USA
    J Mol Biol 310:205-18. 2001
    ..This study provides details of a structural basis for the partially ordered kinetic mechanism proposed for lactose synthase...
  36. ncbi Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions
    M Amado
    Faculty of Health Sciences, School of Dentistry, Copenhagen, Denmark
    Biochim Biophys Acta 1473:35-53. 1999
    ....
  37. pmc Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency
    Stefan Porubsky
    Department of Cellular and Molecular Pathology, German Cancer Research Center, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 104:5977-82. 2007
    ..Our results strongly suggest that iGb3 is unlikely to be an endogenous CD1d lipid ligand determining thymic iNKT selection...
  38. ncbi B4GALT1 gene knockdown inhibits the hedgehog pathway and reverses multidrug resistance in the human leukemia K562/adriamycin-resistant cell line
    Huimin Zhou
    Department of Laboratory Medicine, College of Laboratory Medicine, Dalian Medical University, Dalian, Liaoning Province, People s Republic of China
    IUBMB Life 64:889-900. 2012
    ..We hypothesize that B4GALT1 is responsible for the overcoming multidrug resistance in human leukemia therapy via regulating the activity of the hedgehog signaling pathway...
  39. ncbi Over-expression of beta-1,4-galactosyltransferase V increases the growth of astrocytoma cell line
    S Xu
    Gene Research Center, Medical Center of Fudan University, Shanghai, People s Republic of China
    J Exp Clin Cancer Res 21:409-14. 2002
    ..001) and weaker (P<0.05) respectively compared with the mock transfectant. This indicates that beta-1,4-GalT V was involved in the malignant phenotype of astrocytoma cells, possibly causing the high galactosylation on the cell surface...
  40. ncbi Tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis
    Wei Shone Chen
    National Cancer Research Center, National Health Research Institutes, Department of Surgery, Taipei Veterans General Hospital and National Yang Ming University, Taiwan, Republic of China
    Clin Cancer Res 11:8615-22. 2005
    ..To elucidate the significance of beta-1,4-galactosyltransferase IV (beta-1,4-GT-IV) in the clinical presentation and prognostication of colorectal cancer...
  41. ncbi Galactan biosynthesis in Mycobacterium tuberculosis. Identification of a bifunctional UDP-galactofuranosyltransferase
    L Kremer
    Department of Microbiology and Immunology, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, United Kingdom
    J Biol Chem 276:26430-40. 2001
    ..Ultimately, this may also lead to a more rational approach to drug design to be explored in the context of mycobacterial infections...
  42. ncbi Lysosomal glycosphingolipid recognition by NKT cells
    Dapeng Zhou
    University of Chicago, Department of Pathology, Chicago, IL 60637, USA
    Science 306:1786-9. 2004
    ..We suggest that expression of iGb3 in peripheral tissues may be involved in controlling NKT cell responses to infections and malignancy and in autoimmunity...
  43. ncbi Identification of a Drosophila gene encoding xylosylprotein beta4-galactosyltransferase that is essential for the synthesis of glycosaminoglycans and for morphogenesis
    Yoko Nakamura
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    J Biol Chem 277:46280-8. 2002
    ..A Drosophila cDNA homologous to mammalian beta4-galactosyltransferases was identified using a human beta4GalT7 cDNA as a probe in a BLAST analysis of expressed sequence tags...
  44. ncbi Identification of beta1,4GalT II as a target gene of p53-mediated HeLa cell apoptosis
    Jin Zhou
    Key Laboratory of Glycoconjuates Research, Ministry of Public Health and Gene Research Center, Shanghai Medical College of Fudan University, Shanghai, People s Republic of China
    J Biochem 143:547-54. 2008
    ..Collectively, these results suggested that beta1,4GalT II might serve as a target gene of p53 transcription factor during adriamycin-induced HeLa cell apoptosis, which elucidated a new mechanism of p53-mediated cell apoptosis...
  45. ncbi The expression patterns of beta1,4 galactosyltransferase I and V mRNAs, and Galbeta1-4GlcNAc group in rat gastrocnemius muscles post sciatic nerve injury
    Meijuan Yan
    The Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, People s Republic of China
    Glycoconj J 25:685-701. 2008
    ..It is clear that the single step of beta1,4-galactosylation is performed by a family of beta1,4-galactosyltransferases (beta1,4-GalTs), and that each member of this family may play a distinct role in different tissues and ..
  46. ncbi A pH-sensitive assay for galactosyltransferase
    Chenghua Deng
    Chemical Engineering Department, Virginia Commonwealth University, 601 W Main Street, Richmond, VA 23284, USA
    Anal Biochem 330:219-26. 2004
    ..The assay was used to compare three galactosyltransferases in our collection...
  47. pmc Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans
    Lijun Xia
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, 825 N E 13th St, Oklahoma City, OK 73104, USA
    J Cell Biol 164:451-9. 2004
    ..These data reveal an unexpected requirement for core 1-derived O-glycans during angiogenesis...
  48. ncbi Pig cells that lack the gene for alpha1-3 galactosyltransferase express low levels of the gal antigen
    Ajay Sharma
    Nextran Incorporated, Princeton, NJ 08540, USA
    Transplantation 75:430-6. 2003
    ....
  49. ncbi Differing mechanisms of early and late B cell hyporesponsiveness induced by mixed chimerism
    T Kawahara
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Transplant 5:2821-9. 2005
    ..These results have implications for the potential use of mixed hematopioetic chimerism as an approach to performing organ transplantation in recipients with pre-existing anti-donor IgM antibodies...
  50. ncbi Characterization of the Arabidopsis thermosensitive mutant atts02 reveals an important role for galactolipids in thermotolerance
    Junping Chen
    Plant Stress and Germplasm Development Unit, USDA ARS, 3810 4th Street, Lubbock, TX 79415, USA
    Plant Cell Environ 29:1437-48. 2006
    ..Our results suggest that the DGDG level and/or the ratio of DGDG to MGDG may play an important role in basal as well as acquired thermotolerance in Arabidopsis...
  51. ncbi Beta1,4-galactosyltransferase V regulates self-renewal of glioma-initiating cell
    Yuanyan Wei
    Key Laboratory of Glycoconjuates Research, Ministry of Public Health and Gene Research Center, Shanghai Medical College of Fudan University, Shanghai 200032, People s Republic of China
    Biochem Biophys Res Commun 396:602-7. 2010
    ....
  52. ncbi Arachidonic acid induces an increase of β-1,4-galactosyltransferase I expression in MDA-MB-231 breast cancer cells
    Socrates Villegas-Comonfort
    Departamento de Biologia Celular, CINVESTAV IPN, Av IPN 2508, San Pedro Zacatenco, Mexico, DF 07360, Mexico
    J Cell Biochem 113:3330-41. 2012
    ....
  53. ncbi Estrogen induced β-1,4-galactosyltransferase 1 expression regulates proliferation of human breast cancer MCF-7 cells
    Hee Jung Choi
    Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan, Republic of Korea
    Biochem Biophys Res Commun 426:620-5. 2012
    ....
  54. pmc Identification of key functional residues in the active site of human {beta}1,4-galactosyltransferase 7: a major enzyme in the glycosaminoglycan synthesis pathway
    Ibtissam Talhaoui
    Faculte de Medecine, UMR 7561 CNRS Université de Nancy I, BP 184, 54505 Vandoeuvre les Nancy, France
    J Biol Chem 285:37342-58. 2010
    ..A better understanding of the mechanism underlying GAG assembly paves the way toward GAG-based therapeutics...
  55. ncbi UDP-6-deoxy-6-fluoro-alpha-D-galactose binds to two different galactosyltransferases, but neither can effectively catalyze transfer of the modified galactose to the appropriate acceptor
    C L Schengrund
    Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Carbohydr Res 319:24-8. 1999
    ..Acetylation of 3 gave crystalline 1,2,3,4-tetra-O-acetyl-6-deoxy-6-fluoro-beta-D-galactopyranose, which was converted to the corresponding 1-alpha-phosphate and used for the synthesis of 6...
  56. ncbi Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancer-specific biomarker of colorectal tumors
    Maria Luana Poeta
    Department of Bioscience, Biotechnology and Pharmacological Sciences, University of Bari, Italy
    Genes Chromosomes Cancer 51:1133-43. 2012
    ..These results suggest that the glycogene B4GALT1 represent a valuable candidate biomarker of invasive phenotype of colorectal cancer...
  57. pmc Characterization of endoplasmic reticulum-localized UDP-D-galactose: hydroxyproline O-galactosyltransferase using synthetic peptide substrates in Arabidopsis
    Takuji Oka
    Research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305 8566, Japan
    Plant Physiol 152:332-40. 2010
    ..To our knowledge, this is the first characterization of HGT, and the data provide evidence that arabinogalactan biosynthesis occurs in the protein transport pathway...
  58. ncbi Expression of beta-1,4-galactosyltransferase-I affects cellular adhesion in human peripheral blood CD4+ T cells
    Yu Han
    Department of Microbiology and Immunology, Medical School of Nantong University, 19 Qixiu Road, Nantong, Jiangsu 226001, PR China
    Cell Immunol 262:11-7. 2010
    ..Collectively, the data suggest that beta-1,4-GalT-I plays a role in the cellular adhesion of CD4(+) T cells...
  59. pmc A monogalactosyldiacylglycerol synthase found in the green sulfur bacterium Chlorobaculum tepidum reveals important roles for galactolipids in photosynthesis
    Shinji Masuda
    Center for Biological Resources and Informatics, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    Plant Cell 23:2644-58. 2011
    ..These observations provide new insights regarding the importance of regulated MGDG synthesis in the physiology of higher plants...
  60. ncbi Inhibition of galactosyltransferases by a novel class of donor analogues
    Karine Descroix
    School of Pharmacy, University of East Anglia, Norwich NR4 7TJ, UK
    J Med Chem 55:2015-24. 2012
    b>Galactosyltransferases (GalT) are important molecular targets in a range of therapeutic areas, including infection, inflammation, and cancer. GalT inhibitors are therefore sought after as potential lead compounds for drug discovery...
  61. ncbi Molecular cloning, characteristics and low temperature response of raffinose synthase gene in Cucumis sativus L
    Xiao lei Sui
    College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China
    J Plant Physiol 169:1883-91. 2012
    ..The most notable increase was observed in the leaves. Similarly, the expression of CsRS was induced in cucumber leaves and fruits with 200 μM and 150 μM ABA treatments, respectively...
  62. ncbi Characteristics of immunoglobulin gene usage of the xenoantibody binding to gal-alpha(1,3)gal target antigens in the gal knockout mouse
    S Nozawa
    Transplantation Biology Research Laboratory, Division of Cardiothoracic Surgery, The Keck School of Medicine, University of Southern California, Los Angeles 90027, USA
    Transplantation 72:147-55. 2001
    ..Gal o/o mouse can serve as a useful model for examining the genetic control of antibody/antigen interactions associated with the humoral response to pig xenografts in humans...
  63. ncbi A novel role of lactosylceramide in the regulation of lipopolysaccharide/interferon-gamma-mediated inducible nitric oxide synthase gene expression: implications for neuroinflammatory diseases
    Ravinder Pannu
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 24:5942-54. 2004
    ..To our knowledge this is the first report of a role of LacCer in iNOS expression and the advantage of GSL depletion in attenuating post-SCI inflammation to improve the outcome of SCI...
  64. ncbi Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb3 synthase, that directs the synthesis of isoglobo-glycosphingolipids
    J J Keusch
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Chem 275:25308-14. 2000
    ..As an indirect consequence of the expression cloning strategy used, we have been able to identify several potential glycolipid biosynthetic pathways where iGb(3) functions, including the globo- and isoglobo-series of glycolipids...
  65. ncbi Induction of B-cell tolerance by retroviral gene therapy
    J L Bracy
    Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Blood 96:3008-15. 2000
    ..Thus, gene therapy approaches may be used to overcome immunologic responses leading to xenograft rejection, and similar gene therapy approaches could be used to overcome autoimmunity...
  66. ncbi Differential effects of lobe A and lobe B of the Conserved Oligomeric Golgi complex on the stability of {beta}1,4-galactosyltransferase 1 and {alpha}2,6-sialyltransferase 1
    Romain Peanne
    Unité de Glycobiologie Structurale et Fonctionnelle UMR CNRS 8576, IFR147, Universite des Sciences et Technologies de Lille, Villeneuve d Ascq, France
    Glycobiology 21:864-76. 2011
    ..Lobe B would be crucial in preventing these two Golgi glycosyltransferases from inappropriate retrograde trafficking to the ER, whereas lobe A appears to be essential for maintaining the overall Golgi structure...
  67. ncbi The galactolipid digalactosyldiacylglycerol accumulates in the peribacteroid membrane of nitrogen-fixing nodules of soybean and Lotus
    Nicole Gaude
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    J Biol Chem 279:34624-30. 2004
    ..e. nucleic acid synthesis in bacteroids and host cells...
  68. ncbi On the reaction pathways and determination of transition-state structures for retaining alpha-galactosyltransferases
    Isabelle André
    GlycoDesign Inc, 480 University Avenue, Suite 900, Toronto, ON, Canada M5G 1V2
    Carbohydr Res 338:865-77. 2003
    ..This mechanism is in agreement with both kinetic data in the literature and the description of X-ray structures of retaining glycosyltransferases solved up to today...
  69. ncbi An in vitro model of pig liver xenotransplantation--pig complement is associated with reduced lysis of wild-type and genetically modified pig cells
    Hidetaka Hara
    Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Xenotransplantation 17:370-8. 2010
    ..We investigated in vitro the lysis of wild-type (WT), α1,3-galactosyltransferase gene-knockout (GTKO), and CD46 transgenic (CD46) pig peripheral blood mononuclear cells (PBMC) caused by human anti-pig antibodies (Abs) + pig C...
  70. ncbi The role of tryptophan 314 in the conformational changes of beta1,4-galactosyltransferase-I
    Velavan Ramasamy
    Structural Glycobiology Section, LECB, CCR, NCI Frederick, Building 469, Room 221, 21702, Frederick, MD, USA
    J Mol Biol 331:1065-76. 2003
    ..This study shows the crucial role Trp314 plays in the conformational state of the long loop, in the binding of substrates and in the catalytic mechanism of the enzyme...
  71. ncbi O-GalNAc incorporation into a cluster acceptor site of three consecutive threonines. Distinct specificity of GalNAc-transferase isoforms
    Hideyuki Takeuchi
    Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
    Eur J Biochem 269:6173-83. 2002
    ....
  72. pmc Premature ovarian failure in mice with oocytes lacking core 1-derived O-glycans and complex N-glycans
    Suzannah A Williams
    Department of Cell Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Endocrinology 152:1057-66. 2011
    ..The absence of developing follicles, ovary dysfunction, reduced testosterone and inhibin A, and elevated FSH in double-mutant females lacking C1galt1 and Mgat1 in oocytes represents a new mouse model for the study of follicular POF...
  73. ncbi A single point mutation reverses the donor specificity of human blood group B-synthesizing galactosyltransferase
    Sandra L Marcus
    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada
    J Biol Chem 278:12403-5. 2003
    ..The crystal structure of the mutant reveals the basis for the shift in donor specificity...
  74. ncbi Strategy for the fine characterization of glycosyltransferase specificity using isotopomer assembly
    Hiromi Ito
    Glycogene Function Team of Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology AIST, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    Nat Methods 4:577-82. 2007
    ..We demonstrated the analysis of substrate specificities of five beta4-galactosyltransferases (beta4GalT-I, -II, -III, -IV and -V) using our strategy.
  75. ncbi Regulation of the beta1,4-Galactosyltransferase I promoter by E2F1
    Yuanyan Wei
    Key Laboratory of Glycoconjuates Research, Ministry of Public Health and Gene Research Center, Shanghai Medical College of Fudan University, Shanghai 200032, People s Republic of China
    J Biochem 148:263-71. 2010
    ..Thus, beta1,4GalT I is an important E2F1 target gene that is required for cell cycle progression in mammalian cells, which elicits a new mechanism of cell growth and a new mechanism of beta1,4GalT I transcription...
  76. ncbi Oligosaccharide preferences of beta1,4-galactosyltransferase-I: crystal structures of Met340His mutant of human beta1,4-galactosyltransferase-I with a pentasaccharide and trisaccharides of the N-glycan moiety
    Velavan Ramasamy
    Laboratory of Experimental and Computational Biology, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    J Mol Biol 353:53-67. 2005
    ..Present studies suggest that beta4Gal-T1 interacts preferentially with the 1,2-1,6-arm trisaccharide rather than with the 1,2-1,3-arm or 1,4-1,3-arm of a bi- or tri-antennary oligosaccharide chain of N-glycan...
  77. ncbi Crystal structure of beta1,4-galactosyltransferase complex with UDP-Gal reveals an oligosaccharide acceptor binding site
    B Ramakrishnan
    Structural Glycobiology Section, Laboratory of Experimental and Computational Biology, CCR, NCI, Frederick, MD 21702 1201, USA
    J Mol Biol 318:491-502. 2002
    ..This is an indication that different Gal-T family members prefer different types of glycan acceptors with GlcNAc at their non-reducing ends...
  78. pmc Functional analysis of the galactosyltransferases required for biosynthesis of D-galactan I, a component of the lipopolysaccharide O1 antigen of Klebsiella pneumoniae
    S Guan
    Department of Microbiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Bacteriol 183:3318-27. 2001
    ..Comparison of the biosynthetic pathways for D-galactan I and the polymannose E. coli O9a antigen reveals some interesting features that may reflect a common theme in ABC transporter-dependent O-PS assembly systems...
  79. ncbi Down-regulation of beta1,4-galactosyltransferase V is a critical part of etoposide-induced apoptotic process and could be mediated by decreasing Sp1 levels in human glioma cells
    Jianhai Jiang
    Key Laboratory of Medical Molecular Virology, Ministry of Education and Health, Gene Research Center, Shanghai Medical College of Fudan University Formerly Shanghai Medical University, Shanghai 200032, China
    Glycobiology 16:1045-51. 2006
    ....
  80. ncbi Identification of a novel group of putative Arabidopsis thaliana beta-(1,3)-galactosyltransferases
    Yongmei Qu
    Plant Cell Biology Research Centre, School of Botany, The University of Melbourne, Melbourne, Vic, Australia
    Plant Mol Biol 68:43-59. 2008
    ..AGPs), we adopted a bioinformatic approach to identify and systematically characterise the putative galactosyltransferases (GalTs) responsible for synthesizing the beta-(1,3)-Gal linkage from CAZy GT-family-31 from Arabidopsis ..
  81. ncbi alpha-Lactalbumin (LA) stimulates milk beta-1,4-galactosyltransferase I (beta 4Gal-T1) to transfer glucose from UDP-glucose to N-acetylglucosamine. Crystal structure of beta 4Gal-T1 x LA complex with UDP-Glc
    B Ramakrishnan
    Structural Glycobiology Section, Laboratory of Experimental and Computational Biology, Center for Cancer Research, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 276:37665-71. 2001
    ..Based on the present kinetic and crystal structural studies, a possible explanation for the role of LA in the Glc-T activity has been proposed...
  82. ncbi Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning
    Liangxue Lai
    Department of Animal Science, University of Missouri, Columbia, MO 65211, USA
    Science 295:1089-92. 2002
    ..These pigs were produced by nuclear transfer technology; clonal fetal fibroblast cell lines were used as nuclear donors for embryos reconstructed with enucleated pig oocytes...
  83. ncbi Membrane lipid alteration during phosphate starvation is regulated by phosphate signaling and auxin/cytokinin cross-talk
    Koichi Kobayashi
    Department of Bioscience, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 B 14 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    Plant J 47:238-48. 2006
    ..These results indicate that the observed global change in plant membranes during Pi starvation is not caused by Pi-starvation induced damage in plant cells but rather is strictly regulated by Pi signaling and auxin/cytokinin cross-talk...
  84. ncbi Characterization of an alpha 1----3-galactosyltransferase homologue on human chromosome 12 that is organized as a processed pseudogene
    D H Joziasse
    Department of Medical Chemistry, Vrije Universiteit, Amsterdam, The Netherlands
    J Biol Chem 266:6991-8. 1991
    ..and Hakomori, S. (1990a) J. Biol. Chem. 265, 1146-1151), reveals a significant similarity (39%) suggesting that these two enzymes may have arisen from the same ancestral gene as a result of gene duplication and subsequent divergence...
  85. ncbi Antibody-mediated accommodation of heart grafts expressing an incompatible carbohydrate antigen
    Muhammad M Mohiuddin
    Department of Cardiovascular Thoracic Surgery, Rush University, 1653 West Congress Parkway, Chicago, IL 60612, USA
    Transplantation 75:258-62. 2003
    ..The present study describes an experimental model for antibody-mediated accommodation of organs expressing incompatible carbohydrate antigens...
  86. ncbi Galactosphingolipids and axono-glial interaction in myelin of the central nervous system
    A Bosio
    Molecular Neuroscience Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Cologne, Joseph Stelzmann Strasse 52, D 50931 Cologne, Germany
    Cell Tissue Res 292:199-210. 1998
    ..Increased intracellular concentrations of free ceramides do not trigger apoptosis of oligodendrocytes...
  87. ncbi Novel role of lactosylceramide in vascular endothelial growth factor-mediated angiogenesis in human endothelial cells
    Mohanraj Rajesh
    Johns Hopkins Singapore
    Circ Res 97:796-804. 2005
    ..This finding and the reagents developed in our report may be useful as anti-angiogenic drugs for further studies in vitro and in vivo...
  88. ncbi Oocyte Gal alpha 1,3Gal epitopes implicated in sperm adhesion to the zona pellucida glycoprotein ZP3 are not required for fertilization in the mouse
    A D Thall
    Department of Pathology, University of Michigan, Ann Arbor 48109, USA
    J Biol Chem 270:21437-40. 1995
    ....
  89. ncbi Decreased stability of photosystem I in dgd1 mutant of Arabidopsis thaliana
    Jinkui Guo
    Key Laboratory of Photosynthesis and Environmental Molecular Physiology, Photosynthesis Research Center, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China
    FEBS Lett 579:3619-24. 2005
    ..These results provide evidence that DGDG is important for the stability of the PSI complex...
  90. pmc Immunocytochemical localization of galactosyltransferase in HeLa cells: codistribution with thiamine pyrophosphatase in trans-Golgi cisternae
    J Roth
    J Cell Biol 93:223-9. 1982
    ..The close topological association of both galactosyltransferase and thiamine pyrophosphatase (or nucleoside diphosphatase) suggests a concerted action of both enzymes in glycosylation...
  91. ncbi In vitro biosynthesis of galactans by membrane-bound galactosyltransferase from radish ( Raphanus sativus L.) seedlings
    Hideaki Kato
    Department of Biochemistry and Molecular Biology, Faculty of Science, Saitama University, 255 Shimo okubo, Saitama 338 8570, Japan
    Planta 217:271-82. 2003
    ..The membrane preparation also incorporated [(14)C]Gal into beta-(1-->4)-galactan, indicating that the membranes contained different types of GalT isoform catalyzing the synthesis of different types of galactosidic linkage...
  92. ncbi Structural basis for the inactivity of human blood group O2 glycosyltransferase
    Ho Jun Lee
    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada
    J Biol Chem 280:525-9. 2005
    ....
  93. ncbi Gene therapy to inhibit xenoantibody production using lentiviral vectors in non-human primates
    J Y Fischer-Lougheed
    Department of Cardiothoracic Surgery, The Saban Research Institute of Children s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA 90027, USA
    Gene Ther 14:49-57. 2007
    ..This study is the first to report the application of gene therapy to achieve low-level, long-term gal chimerism sufficient to inhibit production of anti-gal antibodies after immunization with porcine cells in rhesus macaques...
  94. ncbi Cold acclimation of the Arabidopsis dgd1 mutant results in recovery from photosystem I-limited photosynthesis
    Luke Hendrickson
    Umea Plant Science Centre, Department of Plant Physiology, University of Umea, Umeå S 901 87, Sweden
    FEBS Lett 580:4959-68. 2006
    ..We conclude that the relative recovery of photosynthetic activity at 5 degrees C resulted from a temperature/lipid interaction enabling the stable assembly of PSI complexes in the thylakoid...
  95. ncbi Use of lentiviral vectors to induce long-term tolerance to gal(+) heart grafts
    Mary Kearns-Jonker
    Department of Cardiothoracic Surgery, Children s Hospital of Los Angeles and the University of Southern California Keck School of Medicine, Los Angeles, CA 90027, USA
    Transplantation 77:1748-54. 2004
    ..Limitations to the success of this methodology include short-term expression of the introduced gene and rejection of gal hearts transplanted into these animals within a month...
  96. ncbi Expression changes in tolerant murine cardiac allografts after gene therapy with a lentiviral vector expressing alpha1,3 galactosyltransferase
    J M Evans
    Department of Anesthesiology Critical Care Medicine, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California 90027, USA
    Transplant Proc 38:3172-80. 2006
    ..These data suggest that tolerance may be associated with activation of immunomodulatory and survival pathways...
  97. pmc Phase variation in Helicobacter pylori lipopolysaccharide
    B J Appelmelk
    Department of Medical Microbiology, Vrije Universiteit, Medical School, Amsterdam, The Netherlands
    Infect Immun 66:70-6. 1998
    ..Clearly phase variation increases the heterogeneity of H. pylori, and this process may be involved in generating the very closely related yet genetically slightly different strains that have been isolated from one patient...
  98. ncbi Anti-Gal antibody-mediated allograft rejection in alpha1,3-galactosyltransferase gene knockout mice: a model of delayed xenograft rejection
    M J Pearse
    Immunology Research Centre, St Vincent s Hospital, Fitzroy, Australia
    Transplantation 66:748-54. 1998
    ....
  99. ncbi Molecular cloning and characterization of a novel UDP-Gal:GalNAc(alpha) peptide beta 1,3-galactosyltransferase (C1Gal-T2), an enzyme synthesizing a core 1 structure of O-glycan
    Takashi Kudo
    Glycogene Function Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Central 2, Open Space Laboratory, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8586, Japan
    J Biol Chem 277:47724-31. 2002
    ..These results indicated that C1Gal-T2 is the second candidate for core 1 synthase that plays an important role in synthesizing O-glycans in digestive organs...
  100. ncbi Sensitive detection of isoglobo and globo series tetraglycosylceramides in human thymus by ion trap mass spectrometry
    Yunsen Li
    Department of Melanoma Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    Glycobiology 18:158-65. 2008
    ....
  101. ncbi Sequence-function relationships of prokaryotic and eukaryotic galactosyltransferases
    C Breton
    Centre de Recherches sur les Macromolecules Vegetales, Vrije Universiteit, Amsterdam, The Netherlands
    J Biochem 123:1000-9. 1998
    b>Galactosyltransferases are enzymes which transfer galactose from UDP-Gal to various acceptors with either retention of the anomeric configuration to form alpha1,2-, alpha1,3-, alpha1,4-, and alpha1, 6-linkages, or inversion of the ..

Research Grants44

  1. Array-based methylation analysis using anti-5mC antibody
    Fumiichiro Yamamoto; Fiscal Year: 2007
    ..We will evaluate the sensitivity, specificity, and reproducibility of the method, using BAG clone microarrays, DNA fragment microarrays, and oligonucleotide microarrays. [unreadable] [unreadable] [unreadable]..
  2. GLYCOSYLATION MUTANTS OF LEISHMANIA
    Salvatore J Turco; Fiscal Year: 2012
    ..2. To characterize new families of mannosyl-phosphate transferases and galactosyltransferases involved in synthesis of the phosphoglycan (PG) repeating unit Gal(21,4)Man(11)-PO4- backbone. 3...
  3. GALACTOSYLTRANSFERASES--STRUCTURE AND REGULATION
    Keith Brew; Fiscal Year: 2003
    ..Two galactosyltransferases will be investigated that catalyze reactions in which the configuration of the transferred monosaccharide ..
  4. Molecular Genetics of Familial Tumoral Calcinosis
    Jouni Uitto; Fiscal Year: 2009
    ..that this disorder is caused by mutations in GALNT3 encoding ppGalNAc-T3, one of 24 known polypeptide galactosyltransferases. These Golgi-associated biosynthetic enzymes are responsible for mucin type Oglycosylation, a prevalent ..
  5. GLYCOSYLTRANSFERASES AS DRUG TARGETS IN MYCOBACTERIA
    Robert Reynolds; Fiscal Year: 2002
    ..Specifically, glycosyl donor and acceptor analogs of mycobacterial rhamnosyl- galactosyltransferases that utilize nucleoside diphosphate sugar donors UDP-galactofuranose and TDP-rhamnopyranose...
  6. INCREASE/gp120 IMMUNOGENICITY/LINKED ALPHA-GAL EPITOPES
    Uri Galili; Fiscal Year: 2005
    ..We will then also collaborate with a group studying immune responses in monkeys to determine the efficacy of this vaccine in a primate model. ..
  7. PREVENTING ANTI-GAL PRODUCTION AGAINST XENOGRAFTS
    Uri Galili; Fiscal Year: 2003
    ..Success in these studies will help in planning effective treatments for preventing anti-Gal response in primate xenografts recipients. | ..
  8. Xenograft-like rejection of tumors in a-gal glycolipids
    URI GALILI GALILI; Fiscal Year: 2010
    ..We will study this treatment in a unique mouse model that simulates the pertinent human immunological parameters. Success in the studies in the mouse model will enable us to apply this treatment to cancer patients. ..
  9. Tolerance to Carbohydrate Antigens in Transplantation
    David Cooper; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  10. Thromboregulation to Prevent Thrombotic Microangiopathy
    David Cooper; Fiscal Year: 2008
    ..It is anticipated that these approaches will abrogate the development of TM and allow long-term survival of pig organs in baboons. ..
  11. Glycosylation & Biogenesis of Streptococcal Fimbriae
    Hui Wu; Fiscal Year: 2007
    ..Therefore, elucidation of Fap1 glycosylation may provide a framework for understanding the role of glycoslyation in bacterial pathogenesis. ..
  12. Identification of novel bioactive glycans on dystroglycan
    Paul Martin; Fiscal Year: 2007
    ..This proposal, therefore, will not only define a novel function for a therapeutically important enzyme, but likely identify a glycan structure not yet described in mammals. [unreadable] [unreadable]..
  13. NKT Cell Recognition of Streptococcus Pneumoniae
    Mitchell Kronenberg; Fiscal Year: 2008
    ..pneumoniae, which could lead to the development of more effective vaccines against this organism. [unreadable] [unreadable] [unreadable] [unreadable]..
  14. Genetic Analysis-Adhesion of S Sanguis to S Pellicle
    Hui Wu; Fiscal Year: 2008
    ..abstract_text> ..
  15. Galgt2, dystroglycan, and muscle extracellular matrix
    Paul Martin; Fiscal Year: 2008
    ..These experiments will decipher mechanisms responsible for the functional roles of Galgt2 in muscle and neuromuscular development, as well as for its therapeutic role in muscular dystrophy. ..
  16. Deficiency of SHP-1 expression and function in multiple sclerosis
    Paul T Massa; Fiscal Year: 2010
    ..abstract_text> ..
  17. Immunochemistry & Immunobiology 2008 Gordon Research Conference
    Mitchell Kronenberg; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  18. BACTERIAL PHOSPHORYLCHOLINE AND PATHOGENESIS
    Jeffrey Weiser; Fiscal Year: 2009
    ..Aim 3 will determine the effects of the immune response to ChoP on colonization, where our findings demonstrate that expression of ChoP is most important to pathogenesis. ..
  19. Glycosyltransferase Therapy for Myopathies
    PAUL TAYLOR MARTIN; Fiscal Year: 2010
    ..Another long-term goal is to develop a novel connection between glycosylation and myostatin signaling that may more broadly impact therapies for muscle aging and disease. ..
  20. Genomic dissection of platelet production
    Warren Alexander; Fiscal Year: 2009
    ....
  21. CARBOHYDRATE AND NEUROMUSCULAR SYNAPTOGENESIS
    Paul Martin; Fiscal Year: 2002
    ..The identification of a role for Ga1NAc in the targeting of synaptic proteins or in synaptic signaling at the neuromuscular junction would provide new therapeutic avenues for the treatment of neuromuscular diseases. ..
  22. Recognition of bacterial antigens by NKT cells
    Mitchell Kronenberg; Fiscal Year: 2010
    ..abstract_text> ..
  23. Functional Analysis of a Streptococcal GPIb Adhesin
    Hui Wu; Fiscal Year: 2007
    ..This information may lead to new approaches for prevention and treatment of infective endocarditis and other cardiovascular diseases. [unreadable] [unreadable]..
  24. CD40L IN ALLOGRAFT TOLERANCE AND VIRAL IMMUNITY
    Richard Pierson; Fiscal Year: 2001
    ..Finally, this study will investigate the potential of CD40L inhibition to induce prolonged acceptance of a transplanted organ, and may contribute to development of clinically relevant approaches to the induction of tolerance. ..
  25. TOPICAL RETINOIDS FOR DIABETIC FOOT ULCERS
    James Varani; Fiscal Year: 2003
    ..abstract_text> ..
  26. ANTIGEN PRESENTATION AND IMMUNE REGULATION BY CD1
    Mitchell Kronenberg; Fiscal Year: 2004
    ..Suck knowledge could lead to novel immune therapies for cancer and autoimmune disease. ..
  27. Expression of Myomesin and SLIM1 in Heart Failure
    Fen Lai Tan; Fiscal Year: 2004
    ..abstract_text> ..
  28. Epigenetic Alterations in Homeotic Genes
    Fumiichiro Yamamoto; Fiscal Year: 2005
    ..Both the constitutive and inducible expression systems will be used to examine the tumor suppressor function of these homeotic genes. ..
  29. Mechanisms of MMP-3 Action in Acute Lung Injury
    James Varani; Fiscal Year: 2005
    ..These studies will provide an overall understanding of the mechanism(s) by which MMP-3 contributes to acute lung injury. ..
  30. Patterns of ganglioside expression in neuroblastoma
    Karen Kaucic; Fiscal Year: 2003
    ....
  31. Conference on Autoimmunity & Tolerance In Renal Disease
    Jeffrey Platt; Fiscal Year: 2003
    ....
  32. REGULATION OF HEMATOPOIESIS BY THROMBOPOIETIN
    Warren Alexander; Fiscal Year: 2001
    ..abstract_text> ..
  33. SQUAMOUS EPITHELIAL CELL INVASION IN ORGAN CULTURE
    James Varani; Fiscal Year: 2001
    ..abstract_text> ..
  34. Mechanisms of Nucleotide Release by Airway Epithelia
    Eduardo Lazarowski; Fiscal Year: 2006
    ..Delineation of nucleotide-releasing mechanisms will provide new possibilities to improve MCC function in chronic lung diseases characterized by mucin-obstructed and inflamed airways. [unreadable] [unreadable]..
  35. Use of Gene Therapy to Induce Transplantation Tolerance
    Mary Kearns Jonker; Fiscal Year: 2003
    ..abstract_text> ..
  36. Competition Among Bacterial Resiratory Pathogens
    Jeffrey Weiser; Fiscal Year: 2004
    ..Future strategies to decrease disease burden by reducing carriage could result from a greater understanding of interactions between species. ..
  37. Antigen Presentation Pathway by CD1 Molecules
    Mitchell Kronenberg; Fiscal Year: 2006
    ..The results from these studies will aid in our understanding of lipid antigen presentation, and they should help in the design of lipid antigen-based vaccines and in attempts to alter immune regulation by stimulating NK T cells. ..
  38. REGULATION OF INTERFERON ACTIVITY BY SHP-1 IN THE CNS
    PAUL MASSA; Fiscal Year: 2007
    ..We believe that information gained under these specific aims will elucidate mechanisms whereby SHP-1 controls virus infections in oligodendrocytes and perhaps other cells of the CNS. ..
  39. CKIS AND CONTROL OF VASCULAR SMOOTH MUSCLE CELL CYCLE
    David Ginsburg; Fiscal Year: 2001
    ..An understanding of these mechanisms should lend insight into the pathophysiology of vascular diseases, and determine whether enhancement of p21 and p27 expression in arteries may limit excessive vsmc proliferation in these diseases. ..
  40. 2007 Immunobiology and Immunochemistry Gordon Research Conference
    Mitchell Kronenberg; Fiscal Year: 2007
    ..Participation by women and under represented minorities[unreadable] is actively sought. In this application, we seek support for this important and prestigious[unreadable] conference. ..
  41. 2002 Gordon Research Conference on Hemostasis
    David Ginsburg; Fiscal Year: 2002
    ..The extensive interactions and discussion that will occur at this conference will help identify new areas and directions for future research...
  42. GLYCOSYLTRANSFERASE FUNCTION DURING FERTILIZATION
    BARRY SHUR; Fiscal Year: 2006
    ..Finally, in the third Aim, we will continue our analysis of GalT-mediated signal transduction leading to the acrosome reaction. ..