glutathione transferase

Summary

Summary: A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.

Top Publications

  1. ncbi Glutathione transferases
    John D Hayes
    Biomedical Research Center, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    Annu Rev Pharmacol Toxicol 45:51-88. 2005
  2. ncbi Molecular mechanisms of metabolic resistance to synthetic and natural xenobiotics
    Xianchun Li
    Department of Entomology and BIO5, University of Arizona, Tucson, Arizona 85721, USA
    Annu Rev Entomol 52:231-53. 2007
  3. ncbi Insect glutathione transferases and insecticide resistance
    A A Enayati
    School of Public Health, Mazandaran University of Medical Sciences, Sari, Iran
    Insect Mol Biol 14:3-8. 2005
  4. ncbi Evolution of supergene families associated with insecticide resistance
    Hilary Ranson
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Science 298:179-81. 2002
  5. pmc Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily
    D Sheehan
    Department of Biochemistry, University College Cork, Lee Maltings, Prospect Row, Mardyke, Cork, Ireland
    Biochem J 360:1-16. 2001
  6. ncbi Glutathione-S-transferase family of enzymes
    R C Strange
    Centre for Cell and Molecular Medicine, School of Postgraduate Medicine, Keele University, North Staffordshire Hospital, Stoke on Trent, Staffordshire, UK
    Mutat Res 482:21-6. 2001
  7. ncbi A preliminary characterization of the cytosolic glutathione transferase proteome from Drosophila melanogaster
    Chonticha Saisawang
    Institute of Molecular Biosciences, Mahidol University, Salaya Campus, 25 25 Putthamonthol Road 4, Salaya, Nakhon Pathom 73170, Thailand
    Biochem J 442:181-90. 2012
  8. ncbi Roles for glutathione transferases in plant secondary metabolism
    David P Dixon
    Centre for Bioactive Chemistry, School of Biological and Biomedical Sciences, Durham University, Durham DH1 3LE, UK
    Phytochemistry 71:338-50. 2010
  9. pmc Identification of a novel class of insect glutathione S-transferases involved in resistance to DDT in the malaria vector Anopheles gambiae
    H Ranson
    School of Biosciences, Main College, Cardiff University, PO Box 915, Cardiff CF10 3TL, Wales, UK
    Biochem J 359:295-304. 2001
  10. ncbi Genomic organization of the glutathione S-transferase family in insects
    Robert Friedman
    Department of Biological Sciences, University of South Carolina, 715 Sumter Street, Columbia, SC 29208, USA
    Mol Phylogenet Evol 61:924-32. 2011

Detail Information

Publications404 found, 100 shown here

  1. ncbi Glutathione transferases
    John D Hayes
    Biomedical Research Center, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    Annu Rev Pharmacol Toxicol 45:51-88. 2005
    This review describes the three mammalian glutathione transferase (GST) families, namely cytosolic, mitochondrial, and microsomal GST, the latter now designated MAPEG...
  2. ncbi Molecular mechanisms of metabolic resistance to synthetic and natural xenobiotics
    Xianchun Li
    Department of Entomology and BIO5, University of Arizona, Tucson, Arizona 85721, USA
    Annu Rev Entomol 52:231-53. 2007
    ..Differences in the selective regime imposed by allelochemicals and insecticides may account for the relative importance of regulatory or structural mutations in conferring resistance...
  3. ncbi Insect glutathione transferases and insecticide resistance
    A A Enayati
    School of Public Health, Mazandaran University of Medical Sciences, Sari, Iran
    Insect Mol Biol 14:3-8. 2005
    ..This mini review describes the insect GST enzyme family, focusing specifically on their role in conferring insecticide resistance...
  4. ncbi Evolution of supergene families associated with insecticide resistance
    Hilary Ranson
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Science 298:179-81. 2002
    ..The analyses also provide the means for identifying previously unknown molecules involved in fundamental biological processes such as development...
  5. pmc Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily
    D Sheehan
    Department of Biochemistry, University College Cork, Lee Maltings, Prospect Row, Mardyke, Cork, Ireland
    Biochem J 360:1-16. 2001
    ..The implications of this classification with regard to the evolution of GSTs are discussed...
  6. ncbi Glutathione-S-transferase family of enzymes
    R C Strange
    Centre for Cell and Molecular Medicine, School of Postgraduate Medicine, Keele University, North Staffordshire Hospital, Stoke on Trent, Staffordshire, UK
    Mutat Res 482:21-6. 2001
    ..11 and 7.4, respectively) implying that the allelic variants exert a substantial biological effect. These and other data indicate the importance of GST polymorphism in determining disease phenotype...
  7. ncbi A preliminary characterization of the cytosolic glutathione transferase proteome from Drosophila melanogaster
    Chonticha Saisawang
    Institute of Molecular Biosciences, Mahidol University, Salaya Campus, 25 25 Putthamonthol Road 4, Salaya, Nakhon Pathom 73170, Thailand
    Biochem J 442:181-90. 2012
    The cytosolic GST (glutathione transferase) superfamily has been annotated in the Drosophila melanogaster genome database. Of 36 genes, four undergo alternative splicing to yield a total of 41 GST proteins...
  8. ncbi Roles for glutathione transferases in plant secondary metabolism
    David P Dixon
    Centre for Bioactive Chemistry, School of Biological and Biomedical Sciences, Durham University, Durham DH1 3LE, UK
    Phytochemistry 71:338-50. 2010
    ....
  9. pmc Identification of a novel class of insect glutathione S-transferases involved in resistance to DDT in the malaria vector Anopheles gambiae
    H Ranson
    School of Biosciences, Main College, Cardiff University, PO Box 915, Cardiff CF10 3TL, Wales, UK
    Biochem J 359:295-304. 2001
    ..5-fold higher in a DDT resistant strain than in the susceptible strain and demonstrate that recombinant AgGST3-2 has very high DDT dehydrochlorinase activity...
  10. ncbi Genomic organization of the glutathione S-transferase family in insects
    Robert Friedman
    Department of Biological Sciences, University of South Carolina, 715 Sumter Street, Columbia, SC 29208, USA
    Mol Phylogenet Evol 61:924-32. 2011
    ..These expansions are largely explained by the number of protein-coding genes in the genome, although life history is another contributing factor...
  11. pmc Glutathione S-transferases as antioxidant defence agents confer pyrethroid resistance in Nilaparvata lugens
    J G Vontas
    School of Biosciences, Cardiff University, Main College, Museum Avenue, P O Box 915, Cardiff CF10 3TL, Wales, UK
    Biochem J 357:65-72. 2001
    ..lugens is through protecting tissues from oxidative damage. Our study extends the GSTs' range of efficacy to pyrethroid insecticides and possibly explains the role of elevated GSTs in other pyrethroid-resistant insects...
  12. pmc Examination of polymorphic glutathione S-transferase (GST) genes, tobacco smoking and prostate cancer risk among men of African descent: a case-control study
    Nicole A Lavender
    Department of Pharmacology and Toxicology, University of Louisville UofL, School of Medicine, 500 South Preston Street, Room 1319 Research Tower, UofL Health Science Center, Louisville, KY 40202, USA
    BMC Cancer 9:397. 2009
    ..Thus, we evaluated the effects of polymorphic GSTs (M1, T1, and P1) alone and combined with cigarette smoking on PCA susceptibility...
  13. pmc Evolutionary conservation of regulated longevity assurance mechanisms
    Joshua J McElwee
    Department of Biology, University College London, London WC1E 6BT, UK
    Genome Biol 8:R132. 2007
    ..To address this, we have applied a novel, multi-level cross-species comparative analysis to compare gene expression changes accompanying increased longevity in mutant nematodes, fruitflies and mice with reduced IIS...
  14. ncbi Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death
    E Laborde
    Department of Chemistry, Telik, Inc, Palo Alto, CA 94394, USA
    Cell Death Differ 17:1373-80. 2010
    ..This review is focused on the inhibition of GSTs, in particular GSTP1-1, as a potential therapeutic approach for the treatment of cancer and other diseases associated with aberrant cell proliferation...
  15. ncbi The role of glutathione-S-transferase in anti-cancer drug resistance
    Danyelle M Townsend
    Department of Pharmacology, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Oncogene 22:7369-75. 2003
    ..Some of the therapeutic strategies so far employed are described in this review...
  16. ncbi Potential risk modifications of GSTT1, GSTM1 and GSTP1 (glutathione-S-transferases) variants and their association to CAD in patients with type-2 diabetes
    Tharmarajan Ramprasath
    Department of Biochemistry, School of Biological Sciences, Madurai Kamaraj University, Madurai, India
    Biochem Biophys Res Commun 407:49-53. 2011
    ..Recent studies revealed the relationship of GSTs variants with T2DM and CAD. In this case-control study we ascertained the association of GSTs variants in association with the development of CAD in patients with T2DM...
  17. pmc Zeta, a novel class of glutathione transferases in a range of species from plants to humans
    P G Board
    Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, GPO Box 34, Canberra, ACT 2601, Australia
    Biochem J 328:929-35. 1997
    ..The members of the Zeta class have been conserved over a long evolutionary period, suggesting that they might have a role in the metabolism of a compound that is common in many living cells...
  18. ncbi Identification and characterisation of ten glutathione S-transferase genes from oriental migratory locust, Locusta migratoria manilensis (Meyen)
    Guohua Qin
    Research Institute of Applied Biology, Shanxi University, Taiyuan, Shanxi, China Research Centre of Environmental Science and Engineering, Shanxi University, Taiyuan, Shanxi, China
    Pest Manag Sci 67:697-704. 2011
    ..In this paper, ten cDNAs encoding glutathione S-transferases (GSTs) were sequenced and characterised in L. migratoria manilensis. The effects of deltamethrin on the ten GST gene expressions were studied...
  19. ncbi Copy number variation in glutathione-S-transferase T1 and M1 predicts incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer in the general population
    M S Nørskov
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospitals and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Pharmacogenomics J 11:292-9. 2011
    ..9 (1.0-3.7) for GSTM1*0/0 versus GSTM1*1/0. In conclusion, exact CNV in GSTT1 and GSTM1 predict incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer...
  20. pmc Molecular evolution of glutathione S-transferases in the genus Drosophila
    Wai Yee Low
    Department of Genetics, University of Melbourne, Victoria 3010, Australia
    Genetics 177:1363-75. 2007
    ..We propose that the parallel evolution observed at this site is an adaptive response to an environmental toxin and that sequencing of historical alleles suggests that this toxin was not a synthetic insecticide...
  21. ncbi Catalytic function of Drosophila melanogaster glutathione S-transferase DmGSTS1-1 (GST-2) in conjugation of lipid peroxidation end products
    S P Singh
    Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Eur J Biochem 268:2912-23. 2001
    ..g. GSTA4-4). The independent emergence of 4-HNE-conjugating activity in more than one branch of the glutathione S-transferase superfamily suggests that 4-HNE catabolism may be essential for aerobic life...
  22. pmc Purification, molecular cloning, and characterization of glutathione S-transferases (GSTs) from pigmented Vitis vinifera L. cell suspension cultures as putative anthocyanin transport proteins
    Simon Conn
    Department of Medical Biotechnology, Flinders University, Adelaide, Australia
    J Exp Bot 59:3621-34. 2008
    ..Further investigation of these candidate ligandins may identify a mechanism for manipulating anthocyanin accumulation in planta and in vitro suspension cells...
  23. ncbi Polymorphisms in XRCC1 and glutathione S-transferase genes and hepatitis B-related hepatocellular carcinoma
    Ming Whei Yu
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    J Natl Cancer Inst 95:1485-8. 2003
    ..07, 95% confidence interval = 1.67 to 38.93) than for those with the Arg/Arg genotype. Thus, GST status appears to affect the risk of HCC associated with this XRCC1 polymorphism...
  24. pmc Null genotypes of GSTM1 and GSTT1 contribute to risk of cervical neoplasia: an evidence-based meta-analysis
    Lin Bo Gao
    Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children s Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People s Republic of China
    PLoS ONE 6:e20157. 2011
    ..Glutathione S-transferases (GSTs) are multifunctional enzymes that play a key role in the detoxification of varieties of both endogenous products of oxidative stress and exogenous carcinogens...
  25. pmc Polymorphisms of glutathione-S-transferase M1, T1, P1 and the risk of prostate cancer: a case-control study
    Monika Sivoňová
    Department of Medical Biochemistry, Comenius University, Jessenius School of Medicine, Martin, Slovakia
    J Exp Clin Cancer Res 28:32. 2009
    ..A further aim of the study was to evaluate polymorphisms in GST also in patients with prostate cancer in order to compare the evaluated proportions with those found in the control subjects...
  26. ncbi Glutathione S-transferase polymorphisms and their biological consequences
    J D Hayes
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, UK
    Pharmacology 61:154-66. 2000
    ....
  27. ncbi Association of glutathione S-transferases polymorphisms (GSTM1 and GSTT1) with senile cataract: a meta-analysis
    Lei Sun
    Department of Ophthalmology, Fourth Hospital of Harbin Medical University, Harbin, People s Republic of China
    Invest Ophthalmol Vis Sci 51:6381-6. 2010
    ..However, the results are not consistent. In this study, the authors conducted a meta-analysis to assess the association between GSTM1 and GSTT1 null genotypes and the risk for senile cataract...
  28. pmc NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20852 7234, USA
    Lancet 366:649-59. 2005
    ..Associations between polymorphisms in other NAT and GST genes and bladder-cancer risk have been inconsistent...
  29. ncbi Identification, characterization, and crystal structure of the Omega class glutathione transferases
    P G Board
    Molecular Genetics Group and Human Genetics Group, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 2601, Australia
    J Biol Chem 275:24798-806. 2000
    ..Unlike other mammalian GSTs, GSTO 1-1 appears to have an active site cysteine that can form a disulfide bond with glutathione...
  30. pmc Glutathione-S-transferase (GST) P1, GSTM1, exercise, ozone and asthma incidence in school children
    T Islam
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Los Angeles, Los Angeles, CA 90033, USA
    Thorax 64:197-202. 2009
    ....
  31. ncbi Elevated activity of an Epsilon class glutathione transferase confers DDT resistance in the dengue vector, Aedes aegypti
    Nongkran Lumjuan
    Vector Research Group, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
    Insect Biochem Mol Biol 35:861-71. 2005
    ..Characterisation of recombinant AaGSTE2-2 confirmed the role of this enzyme in DDT metabolism. In addition, unlike its Anopheles ortholog, AaGSTE2-2 also exhibited glutathione peroxidase activity...
  32. ncbi Contribution of the NQO1 and GSTT1 polymorphisms to lung adenocarcinoma susceptibility
    Noriaki Sunaga
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 11:730-8. 2002
    ..Therefore, carcinogens in tobacco smoke, which are activated by NQO1 and detoxified by GSTT1, could have a role in lung adenocarcinoma development...
  33. pmc Enzyme activities and subcellular localization of members of the Arabidopsis glutathione transferase superfamily
    David P Dixon
    School of Biological and Biomedical Sciences, Durham University, Durham DH1 3LE, UK
    J Exp Bot 60:1207-18. 2009
    ..employed to examine the functional activities and subcellular localization of members of the Arabidopsis glutathione transferase (GST) superfamily...
  34. ncbi Metabolic enzymes associated with xenobiotic and chemosensory responses in Nasonia vitripennis
    J G Oakeshott
    Commonwealth Scientific and Industrial Research Organisation Entomology, Acton, ACT, Australia
    Insect Mol Biol 19:147-63. 2010
    ..vitripennis, that are thought to encounter a wider range of potentially toxic xenobiotics in their diet and habitat...
  35. ncbi Comparative analysis of detoxification enzymes in Acyrthosiphon pisum and Myzus persicae
    J S Ramsey
    Boyce Thompson Institute for Plant Research, Ithaca, NY, USA
    Insect Mol Biol 19:155-64. 2010
    ..However, given the incomplete M. persicae cDNA data set, the number of identified detoxification genes in this species is likely to be an underestimate...
  36. ncbi A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer
    Christoph Sachse
    Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Carcinogenesis 23:1839-49. 2002
    ..This data suggests that heterocyclic amines do not play an important role in the aetiology of colorectal cancer but that exposure to other carcinogens such as polycyclic aromatic hydrocarbons may be important determinants of cancer risk...
  37. ncbi Glutathione transferases: a structural perspective
    Aaron Oakley
    School of Chemistry, University of Wollongong, Wollongong, Australia
    Drug Metab Rev 43:138-51. 2011
    ..In this review, the major insights into GST structure and function will be discussed...
  38. pmc Purification, molecular cloning and heterologous expression of a glutathione S-transferase involved in insecticide resistance from the rice brown planthopper, Nilaparvata lugens
    John G Vontas
    School of Biosciences, Cardiff University, Main College, Museum Avenue, Cardiff CF10 3TL, Wales, UK
    Biochem J 362:329-37. 2002
    ..Southern analysis of genomic DNA from the resistant and susceptible strains indicated that GST-based insecticide resistance may be associated with gene amplification in N. lugens...
  39. pmc Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications
    Mariet Allen
    Mayo Clinic Florida, Department of Neuroscience, Jacksonville, FL, USA
    Mol Neurodegener 7:13. 2012
    ..4,617 controls) and PD (678 PDs vs. 712 controls) for association with disease risk (case-controls), age-at-diagnosis (cases) and brain gene expression levels (autopsied subjects)...
  40. ncbi Glutathione S-transferases: an overview in cancer research
    Giuliano Di Pietro
    Universidade Estadual de Santa Cruz, Departamento de Ciências da Saúde, Laboratório de Farmacogenômica e Epidemiologia Molecular LAFEM, Ilheus, Bahia 45662 900, Brazil
    Expert Opin Drug Metab Toxicol 6:153-70. 2010
    ....
  41. pmc Association of a deletion of GSTT2B with an altered risk of oesophageal squamous cell carcinoma in a South African population: a case-control study
    Marco Matejcic
    International Centre for Genetic Engineering and Biotechnology, Cape Town Component, Observatory, Cape Town, South Africa
    PLoS ONE 6:e29366. 2011
    ....
  42. ncbi Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents
    Larry G Higgins
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    Drug Metab Rev 43:92-137. 2011
    b>Glutathione transferase (GST) isoezymes are encoded by three separate families of genes (designated cytosolic, microsomal and mitochondrial transferases), with distinct evolutionary origins, that provide mammalian species with protection ..
  43. ncbi Glutathione S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) and prostate cancer: a case-control study in Tehran, Iran
    M R Safarinejad
    Prostate Cancer Prostatic Dis 14:105-13. 2011
    ..62 (95% CI: 2.31-5.74; P=0.004). The results obtained demonstrated that simultaneous presence of three potentially risk alleles (GSTM1 null, GSTT1 null and GSTP1 Val) lead to a significant OR increase for PCa...
  44. ncbi Are GSTM1, GSTT1 and CAG repeat length of androgen receptor gene polymorphisms associated with risk of prostate cancer in Iranian patients?
    Zahra Ousati Ashtiani
    Department of Medical Genetics, School of Medicine, Tehran University of Medical Science, Tehran, Iran
    Pathol Oncol Res 17:269-75. 2011
    ..4, 95% CI 1.53-46.73). Our results showed that CAG repeat polymorphism in AR gene may act as a risk modifier and GSTM1 null genotypes also may be contributed to prostate cancer susceptibility in Iranian patients...
  45. pmc Maternal smoking, GSTM1 and GSTT1 polymorphism and susceptibility to adverse pregnancy outcomes
    Regina Grazuleviciene
    Vytautas Magnus University, K Donelaicio g 58, LT 44248, Kaunas, Lithuania
    Int J Environ Res Public Health 6:1282-97. 2009
    ....
  46. ncbi Association of GSTM1T1 genes with COPD and prostate cancer in north Indian population
    Hitender Thakur
    Department of Biotechnology, Panjab University, Chandigarh, India
    Mol Biol Rep 38:1733-9. 2011
    ..36-3.65 P value = 0.001) and twofold risk in BPH (OR 2.09; 95% CI 1.26-3.46; P value = 0.005). In case of COPD only null genotype of GSTT1 has shown 2.1-fold (OR 2.11; 95% CI 1.22-3.62; P value = 0.007) significant increased risk...
  47. pmc The association of glutathione S-transferase GSTT1 and GSTM1 gene polymorphism with pseudoexfoliative glaucoma in a Pakistani population
    Muhammad Imran Khan
    Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan
    Mol Vis 16:2146-52. 2010
    ..The aim of the present study was to investigate the association of glutathione S-transferase GSTT1 and GSTM1 genotypes with pseudoexfoliative glaucoma (PEXG) in a group of Pakistani patients...
  48. ncbi Evaluation of the influence of polymorphic variants CYP1A1 2B, CYP1B1 2, CYP3A4 1B, GSTM1 0, and GSTT1 0 in prostate cancer
    Iara S Rodrigues
    Departamento de Biologia Geral, CCB, Londrina, Brazil
    Urol Oncol 29:654-63. 2011
    ..In the present study, 5 polymorphic variants were examined in 154 patients with prostate carcinoma and in 154 controls...
  49. ncbi Polymorphisms of glutathione-S-transferase M1 and T1 and prostate cancer risk in a Tunisian population
    Yousra Souiden
    Laboratory of Molecular Biology, Hospital of Ibn Eljazzar of Kairouan, avenue Ibn ElJazzar, Kairouan 3140, Tunisia
    Cancer Epidemiol 34:598-603. 2010
    ..This study is focused on the polymorphic enzymes glutathione-S-transferase M1 (GSTM1) and T1 (GSTT1) that involved in the detoxification of many xenobiotics involved in the etiology of prostate cancer...
  50. ncbi Glutathione transferases in the genomics era: new insights and perspectives
    Carla Frova
    Department of Biomolecular Sciences and Biotechnology, University of Milano, Via Celoria 26, 20133 Milano, Italy
    Biomol Eng 23:149-69. 2006
    ..Among the aspects considered are the redefinition of GST subfamilies, their evolution in connection with structurally related families, present and future biotechnological outcomes...
  51. ncbi GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high-risk population
    Rayjean J Hung
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 110:598-604. 2004
    ..26 (95% CI = 1.06-9.95). SULT1A1 Arg213His polymorphism showed a marginal protective effect. These findings suggest that individual susceptibility to bladder cancer may be modulated by GSTM1, GSTT1 and NAT2 polymorphisms...
  52. ncbi Identification, genomic organization and expression pattern of glutathione S-transferase in the silkworm, Bombyx mori
    Quanyou Yu
    The Key Sericultural Laboratory of Agricultural Ministry, College of Biotechnology, Southwest University, Chongqing, China
    Insect Biochem Mol Biol 38:1158-64. 2008
    ..This may explain the sensitivity of the silkworm to certain insecticides. Our data provide some insights into the evolution of the B. mori GST family and the functions of individual GST enzymes...
  53. ncbi Glutathione transferases in bacteria
    Nerino Allocati
    Dipartimento di Scienze Biomediche, Universita G D Annunzio, Chieti, Italy
    FEBS J 276:58-75. 2009
    ..This review article summarizes the current status of knowledge regarding the functional and structural properties of bacterial GSTs...
  54. ncbi Oxidative stress in Caenorhabditis elegans: protective effects of the Omega class glutathione transferase (GSTO-1)
    Cora Burmeister
    Institute for Animal Physiology, University of Muenster, Hindenburgplatz 55, Muenster 48143, Germany
    FASEB J 22:343-54. 2008
    ..Specific silencing of the GSTO-1 by RNAi created worms with an increased sensitivity to several prooxidants, arsenite, and heat shock. We conclude that the stress-responsive GSTO-1 plays a key role in counteracting environmental stress...
  55. ncbi Glutathione-S-transferases M1 (GSTM1) and GSTT1 genotype, smoking, consumption of alcohol and tea and risk of esophageal and stomach cancers: a case-control study of a high-incidence area in Jiangsu Province, China
    Chang Ming Gao
    Division of Epidemiology, Jiangsu Province Institute of Cancer Research, 42 Baiziting, Nanjing 210009, China
    Cancer Lett 188:95-102. 2002
    ..These findings suggest the GSTM1 polymorphism is involved in the susceptibility to esophageal cancer development, and tea consumption reduces the risk of esophageal and stomach cancers...
  56. ncbi Glutathione S-transferase in the defence against pyrethroids in insects
    I Kostaropoulos
    Laboratory of Animal Physiology, Department of Zoology, School of Biology, Aristotle University of Thessaloniki, 54006, Thessaloniki, Greece
    Insect Biochem Mol Biol 31:313-9. 2001
    ..According to this, GST offers a passive protection towards pyrethroid insecticides by binding to their molecule in a sequestering mechanism...
  57. ncbi Genetic polymorphisms of glutathione S-transferases M1 and T1 associated with susceptibility to aflatoxin-related hepatocarcinogenesis among chronic hepatitis B carriers: a nested case-control study in Taiwan
    C A Sun
    School of Public Health, National Defense Medical Center, Taipei, Taiwan
    Carcinogenesis 22:1289-94. 2001
    ..These results demonstrate the importance of gene-environment interactions in the multifactorial development of HCC...
  58. ncbi Polymorphisms at GSTM1 and GSTP1 gene loci and risk of prostate cancer in a South Indian population
    K Vijayalakshmi
    Department of Human Genetics, Sri Ramachandra Medical College and Research Institute Deemed University, Chennai 600116, Tamil Nadu, India
    Asian Pac J Cancer Prev 6:309-14. 2005
    ..Thus our study indicates that the GSTP1 Ile/Val genotype may decrease risk of prostate cancer in the South Indian population...
  59. ncbi Glutathione S-transferase-mu (GSTM1) and -theta (GSTT1) genotypes in the etiology of prostate cancer
    T R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Cancer Epidemiol Biomarkers Prev 8:283-7. 1999
    ..GST-theta is highly expressed in the prostate and can produce genotoxic effects upon exposure to specific carcinogens. These results suggest that GSTT1 is associated with CaP risk...
  60. ncbi Polymorphism of GSTM1 and GSTT1 genes in prostate cancer: a study from North India
    R D Mittal
    Department of Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226 014, India
    Indian J Cancer 41:115-9. 2004
    ..AIM, SETTING AND DESIGN: In the present study, we examined the association of the GSTM1 and GSTT1 gene polymorphisms with sporadic prostate cancer patients in north Indian population...
  61. ncbi Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk
    Michael A Joseph
    Department of Oncological Sciences, Mt Sinai School of Medicine, New York, NY 10029, USA
    Nutr Cancer 50:206-13. 2004
    ....
  62. ncbi Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight
    Xiaobin Wang
    Department of Pediatrics, Boston University School of Medicine and Boston Medical Center, 91 E Concord St, Maternity 4, Boston, MA 02118, USA
    JAMA 287:195-202. 2002
    ..Little is known about genetic susceptibility to cigarette smoke in relation to adverse pregnancy outcomes...
  63. ncbi Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer
    L W Harries
    Imperial Cancer Research Fund, Ninewells Hospital and Medical School, Dundee, UK
    Carcinogenesis 18:641-4. 1997
    ..However, these were not statistically significant. No change in breast or colon cancer allele frequencies was observed...
  64. pmc Developmentally restricted genetic determinants of human arsenic metabolism: association between urinary methylated arsenic and CYT19 polymorphisms in children
    Maria Mercedes Meza
    Department of Natural Resources, Sonora Institute of Technology ITSON, Ciudad Obregon, Sonora, Mexico
    Environ Health Perspect 113:775-81. 2005
    ....
  65. pmc Glutathione S transferase deficiency and passive smoking increase childhood asthma
    M Kabesch
    University Children s Hospital, Ludwig Maxmilians University Munich, Lindwurmstrasse 4, D 80337 Munich, Germany
    Thorax 59:569-73. 2004
    ..It has been suggested that the genetically determined deficiency of glutathione S transferase (GST) enzymes involved in the detoxification of environmental tobacco smoke (ETS) components may contribute to the development of asthma...
  66. pmc Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family
    O Turunen
    Haartman Institute, Department of Virology, Helsinki University, Finland
    J Cell Biol 126:1445-53. 1994
    ..The actin-binding capability of ezrin supports its proposed role as a membrane-cytoskeleton linker...
  67. ncbi Transcriptomic profiles of Drosophila melanogaster third instar larval midgut and responses to oxidative stress
    H M Li
    Department of Entomology, Purdue University, West Lafayette, IN 47907, USA
    Insect Mol Biol 17:325-39. 2008
    ..We also investigated the response of GSTs in the midgut to dietary H2O2, which showed a dosage-based differential response...
  68. ncbi Glutathione S-transferase polymorphisms: cancer incidence and therapy
    C C McIlwain
    Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29425, USA
    Oncogene 25:1639-48. 2006
    ..Presently, at least two drugs are in late-stage clinical testing. The evolving functions of GST and their divergent expression patterns in individuals make them an attractive target for drug discovery...
  69. ncbi Null genotypes of GSTM1 and GSTT1 contribute to hepatocellular carcinoma risk: evidence from an updated meta-analysis
    Bin Wang
    The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, China
    J Hepatol 53:508-18. 2010
    ..Thus, a meta-analysis was performed to clarify the effects of GSTM1 and GSTT1 polymorphisms on HCC risk...
  70. ncbi Polymorphisms of CYP1A1 and GSTM1 and laryngeal cancer risk: evidence-based meta-analyses
    Wen lei Zhuo
    Institute of Cancer, Xinqiao Hospital, Third Military Medical University, 400038 Chongqing, China
    J Cancer Res Clin Oncol 135:1081-90. 2009
    ..The aim of the present study was to assess the possible associations of laryngeal cancer risk with CYP1A1 genetic variation and GSTM1 null genotype respectively...
  71. ncbi Copy number variation in glutathione S-transferases M1 and T1 and ischemic vascular disease: four studies and meta-analyses
    Marianne S Nørskov
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark
    Circ Cardiovasc Genet 4:418-28. 2011
    ..We tested the hypothesis that copy number variation (CNV) in GSTM1 and GSTT1 genes, known to be associated with stepwise decreases in catalytic activity, predict risk of IVD...
  72. ncbi Glutathione S transferase activity in Indian vectors of malaria: A defense mechanism against DDT
    K Gunasekaran
    Division of Vector Biology and Control, Vector Control Research Centre Indian Council of Medical Research, Indira Nagar, Pondicherry 605 006, India
    J Med Entomol 48:561-9. 2011
    ..fluviatilis, which had a GST activity of 20.0 micromol/min/mg. Also, the GST-mediated DDT detoxification was confirmed by comparing GST activity in wild-caught females with that in their F1 progeny...
  73. pmc Genetic polymorphisms of phase II metabolic enzymes and lung cancer susceptibility in a population of Central South China
    Han Chun Chen
    Department of Biochemistry, Xiangya School of Medicine, Central South University, Changsha 410078, Hunan, China
    Dis Markers 22:141-52. 2006
    ..All these findings suggest that the genetic polymorphisms of phase II metabolic enzymes affect the susceptibility of lung cancer in the Han ethnic group of Central South China...
  74. ncbi Heterologous expression and characterization of a sigma glutathione S-transferase involved in carbaryl detoxification from oriental migratory locust, Locusta migratoria manilensis (Meyen)
    Guohua Qin
    Research Institute of Applied Biology, Shanxi University, Taiyuan, Shanxi 030006, China
    J Insect Physiol 58:220-7. 2012
    ..The nymph mortalities after carbaryl treatment increased 38.7% after LmGSTs3 were silenced. These results suggest that LmGSTs3 may be involved in carbaryl detoxification in L. migratoria manilensis...
  75. ncbi Erythrocyte glutathione transferase: a novel biomarker to check environmental pollution hazardous for humans
    Raffaele Fabrini
    Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, 00133 Rome, Italy
    Biochem Biophys Res Commun 426:71-5. 2012
    b>Glutathione transferase (GST) is an enzyme capable of protecting the body from a lot of toxic compounds. Previous studies demonstrated that the erythrocyte GST (e-GST) expression increases as the level of circulating toxins increases...
  76. pmc Multi-institutional prostate cancer study of genetic susceptibility in populations of African descent
    Emanuela Taioli
    Institute of Translational Epidemiology, Mount Sinai School of Medicine, New York, NY, USA
    Carcinogenesis 32:1361-5. 2011
    ..Gene-environment interaction between smoking and GSTM1 may be involved in the etiology of prostate cancer in populations of African descent...
  77. ncbi Genetic Polymorphism in Glutathione Transferases (GST): Population distribution of GSTM1, T1, and P1 conjugating activity
    Gary Ginsberg
    Connecticut Department of Public Health, Hartford 06134, USA
    J Toxicol Environ Health B Crit Rev 12:389-439. 2009
    ..Ideally, such assessments would involve physiologically based toxicokinetic (PBTK) modeling to assess population variability in internal dose...
  78. ncbi Lung cancer susceptibility and polymorphisms of glutathione-S-transferase genes in Hong Kong
    Moira Chan-Yeung
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, SAR, PR China
    Lung Cancer 45:155-60. 2004
    ..To study the potential role of genetic polymorphisms of glutathione-S-transferases GSTM1, GSTT1 and GSTP1 in susceptibility to lung cancer in Hong Kong Chinese...
  79. ncbi Dietary isothiocyanates, glutathione S-transferase -M1, -T1 polymorphisms and lung cancer risk among Chinese women in Singapore
    B Zhao
    Department of Community, Occupational and Family Medicine, Faculty of Medicine, National University of Singapore, Singapore 117597
    Cancer Epidemiol Biomarkers Prev 10:1063-7. 2001
    ..Conjugation and elimination of ITCs is enhanced in GST-non-null relative to -null individuals, such that the GST metabolic genotype modifies the protective effect of ITCs on lung cancer development...
  80. ncbi Glutathione S-transferases related to P. aeruginosa lung infection in cystic fibrosis children: preliminary study
    Marie Noëlle Feuillet-Fieux
    Assistance Publique Hopitaux de Paris, Necker Enfants Malades Hospital, Laboratory of Biochemistry A, 149 rue de Sevres, 75015 Paris, France
    Clin Biochem 42:57-63. 2009
    ..In cystic fibrosis (CF) children, we investigated the predictive impact of glutathione S-transferases (GST) activity and genotypes P1, M1 and T1, and antioxidant levels on stage-severity of Pseudomonas aeruginosa lung infection...
  81. ncbi Glutathione transferases and development of new principles to overcome drug resistance
    Andrea Sau
    Department of Chemical Sciences and Technologies, University of Tor Vergata, Rome, Italy
    Arch Biochem Biophys 500:116-22. 2010
    ..Here we present an overview of the GST inhibitors and the GST-activated pro-drugs utilized to date to overcome drug resistance...
  82. ncbi Studies on the glutathione S-transferase proteome of adult Drosophila melanogaster: responsiveness to chemical challenge
    Zazali Alias
    School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
    Proteomics 7:3618-28. 2007
    ..PhB treatment led to increases in the relative amounts of the D1, D2, E3, E6, E7 and E9 isoforms detected with a possible depression in the relative amount of GSTS1. CG16936 was unaffected by either pretreatment...
  83. ncbi TRANSPARENT TESTA 19 is involved in the accumulation of both anthocyanins and proanthocyanidins in Arabidopsis
    Satoshi Kitamura
    Department of Ion Beam Applied Biology, Japan Atomic Energy Research Institute, 1233 Watanuki machi, Takasaki, Gunma 370 1292, Japan
    Plant J 37:104-14. 2004
    ..As involvement of GST in the PA pathway was previously considered unlikely, the function of TT19 in the PA pathway is also discussed in the context of the putative transporter for PA precursors...
  84. ncbi Genetic polymorphisms of human cytosol glutathione S-transferases and prostate cancer
    Takahiko Katoh
    Kumamoto University, Department of Public Health, Graduate School of Medical Sciences, Kumamoto 860 8556, Japan
    Pharmacogenomics 9:93-104. 2008
    ..Recent meta-analysis reports show that these polymorphisms of GSTM1, GSTT1 and GSTP1 are unlikely to be major determinants of susceptibility to prostate cancer...
  85. ncbi Genetic polymorphism in myeloperoxidase but not GSTM1 is associated with risk of lung squamous cell carcinoma in a Chinese population
    Wenfu Lu
    Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100 021, China
    Int J Cancer 102:275-9. 2002
    ..3%) but was not associated with risk of lung cancer alone or in combination with the MPO polymorphism. Our results confirm the previous reports showing that the variant A allele of MPO has a protective effect against risk of lung cancer...
  86. pmc Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux
    Francesca Binda
    Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Kennedy Centerfor Research on Human Development, Vanderbilt University, 7124 MRBIII, 465 21st Avenue S, Nashville, TN 37232, USA
    Mol Pharmacol 74:1101-8. 2008
    ..These data suggest that AMPH activation of CaMKII supports DAT/SYN1A association, resulting in a mode of DAT capable of DA efflux...
  87. pmc Additional selection for insecticide resistance in urban malaria vectors: DDT resistance in Anopheles arabiensis from Bobo-Dioulasso, Burkina Faso
    Christopher M Jones
    Vector Group, Liverpool School of Tropical Medicine, Liverpool, Merseyside, United Kingdom
    PLoS ONE 7:e45995. 2012
    ..rural areas, and an increase in transcript levels of several detoxification genes, notably from the glutathione transferase and cytochrome P450 gene families...
  88. ncbi Size effect of elemental selenium nanoparticles (Nano-Se) at supranutritional levels on selenium accumulation and glutathione S-transferase activity
    Dungeng Peng
    School of Chemistry and Materials of Science, University of Science and Technology of China, Hefei 230052, Anhui, PR China
    J Inorg Biochem 101:1457-63. 2007
    ....
  89. ncbi Further insight into the impact of sodium selenite on selenoenzymes: high-dose selenite enhances hepatic thioredoxin reductase 1 activity as a consequence of liver injury
    Jinsong Zhang
    University of Science and Technology of China, Hefei, Anhui 230052, PR China
    Toxicol Lett 176:223-9. 2008
    ..High-dose SS affects hepatic GST more readily than hepatic TrxR1. Thus, the cancer-preventive mechanism of Se at non-toxic supranutritional levels relies more on its modulation of GST rather than TrxR1, at least in liver tissue...
  90. pmc Characterization of a highly effective protein substrate for analysis of JAK2(V617F) Activity
    Zhe Li
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Exp Hematol 35:1624-32. 2007
    ..This study is intended to identify a sensitive and specific substrate for assays of the JAK2 enzymatic activity...
  91. ncbi Glutathione S-transferase genetic polymorphisms (GSTM1, GSTT1 and GSTO2) in three Iranian populations
    Laleh Rafiee
    Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
    Mol Biol Rep 37:155-8. 2010
    ..328). The prevalence of GSTT1 null genotype in Iranian Georgians showed significant difference with Persians and other Asian countries, but it seems to be similar with the frequency which was reported from European populations...
  92. ncbi Susceptibility to urinary bladder cancer: relevance of rs9642880[T], GSTM1 0/0 and occupational exposure
    Klaus Golka
    Leibniz Research Centre for Working Environment and Human Factors IfADo, Ardeystrasse, Dortmund, Germany
    Pharmacogenet Genomics 19:903-6. 2009
    ..Therefore, the degree to which rs9642880[T] and GSTM1 0/0 confer susceptibility to urinary bladder cancer seems to depend on the extent of exposure to urinary bladder carcinogens...
  93. ncbi Expression and characterization of three new glutathione transferases, an epsilon (AcGSTE2-2), omega (AcGSTO1-1), and theta (AcGSTT1-1) from Anopheles cracens (Diptera: Culicidae), a major Thai malaria vector
    Jeerang Wongtrakul
    Research Institute for Health Sciences, Chiang Mai University, PO Box 80 CMU, Chiang Mai, 50200, Thailand
    J Med Entomol 47:162-71. 2010
    ..The theta AcGSTT1-1 functioned not only as peroxidase but also acted as a binding protein for organophosphates. The omega GST had thiol transferase activity suggesting a role in oxidative stress response...
  94. ncbi Polymorphism in glutathione S-transferases: susceptibility and treatment outcome for head and neck cancer
    Munindra Ruwali
    Developmental Toxicology Division, Indian Institute of Toxicology Research Council of Scientific and Industrial Research, Lucknow, U P
    Xenobiotica 41:1122-30. 2011
    ..The present data thus provides evidence for the association of polymorphisms in GSTs with risk for HNSCC and its treatment response...
  95. ncbi Glutathione S-transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1
    S G Cho
    National Creative Research Initiative Center for Cell Death, Graduate School of Biotechnology, Korea University, Anam Dong, Sungbuk Ku, Seoul 136 701, South Korea
    J Biol Chem 276:12749-55. 2001
    ....
  96. pmc Association of GSTM1 and GSTT1 polymorphism with lipid peroxidation in benign prostate hyperplasia and prostate cancer: a pilot study
    Vivek Kumar
    Department of Biochemistry, University College of Medical Sciences and GTB Hospital, University of Delhi, Dilshad Garden, Delhi, India
    Dis Markers 30:163-9. 2011
    ..Double deletion (GSTM1-/GSTT1-) is associated with higher oxidative stress which might play a role in the pathogenesis of BPH and prostate cancer. However, other markers of oxidative stress should be analyzed before any firm conclusion...
  97. ncbi Induction effects of host plants on insecticide susceptibility and detoxification enzymes of Bemisia tabaci (Hemiptera: Aleyrodidae)
    Wen Xie
    Department of Plant Protection, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China
    Pest Manag Sci 67:87-93. 2011
    ..To illustrate the induced changes by host plant, bioassay and biochemical research on five different host populations were investigated...
  98. pmc Multiple insecticide resistance mechanisms involving metabolic changes and insensitive target sites selected in anopheline vectors of malaria in Sri Lanka
    M Devika B Perera
    Department of Zoology, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka
    Malar J 7:168. 2008
    ....
  99. ncbi GSTM1, GSTT1, GSTP1, GSTA1 and colorectal cancer risk: a comprehensive meta-analysis
    Konstantinos P Economopoulos
    School of Medicine, National University of Athens, Greece
    Eur J Cancer 46:1617-31. 2010
    ..GSTA1 *A/*B polymorphism was not associated with colorectal cancer risk. GSTM1 and GSTT1 null genotypes confer additional risk for colorectal cancer in Caucasian populations...
  100. ncbi Association of common copy number variants at the glutathione S-transferase genes and rare novel genomic changes with schizophrenia
    B Rodriguez-Santiago
    Unitat de Genètica, Universitat Pompeu Fabra, and Centro de Investigación Biomédica en Red de Enfermedades Raras CIBERER, Barcelona, Spain
    Mol Psychiatry 15:1023-33. 2010
    ..Our data provide complementary evidences for low prevalent, but highly penetrant chromosomal variants associated with schizophrenia, as well as for common CNVs that may act as susceptibility factors by disturbing glutathione metabolism...
  101. ncbi Germline glutathione S-transferase variants in breast cancer: relation to diagnosis and cutaneous long-term adverse effects after two fractionation patterns of radiotherapy
    Hege Edvardsen
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Centre, Oslo, Norway
    Int J Radiat Oncol Biol Phys 67:1163-71. 2007
    ..To explore whether certain glutathione S-transferase (GST) polymorphisms are associated with an increased risk of breast cancer or the level of radiation-induced adverse effects after two fractionation patterns of adjuvant radiotherapy...

Research Grants67

  1. Mitochondrial Dysfunction and Adipose Insulin Resistance
    David A Bernlohr; Fiscal Year: 2013
    ..If the hypothesis is proven to be correct, the study would be immediately translatable to human biology and afford a new view of how type 2 diabetes may be combated. ..
  2. Preclinical Development of JS-K, a Novel NO-Generating Prodrug for Cancer
    Paul J Shami; Fiscal Year: 2012
    ..This new drug then goes one step further: it will improve the quality of life for cancer patients, their caregivers and families by providing a significantly more effective and less painful therapy than is currently available. ..
  3. Arsenic Trioxide and Acute Myeloid Leukemia
    Yongkui Jing; Fiscal Year: 2012
    ..Our goal will be to utilize As2O3 in combination with 4 HPR or EA analogs in clinical trials in patients with refractory, secondary or in elderly patients with acute myelogenous leukemia. ..
  4. Role of Glutathione S-Transferase P in Heart Failure
    Sumanth D Prabhu; Fiscal Year: 2013
    ....
  5. Mitochondrial Dysfunction and Adipose Insulin Resistance
    DAVID BERNLOHR; Fiscal Year: 2009
    ..Aim 3. Develop and characterize aP2-HA-GSTA4 transgenic mice maintained on low and high fat diets. Aim 4. Characterize the regulation of insulin signaling by the Trx2-ASK1-JNK pathway in animal and cell culture models...
  6. Prolactin as a Growth Factor in Breast Cancer
    Nira Ben-Jonathan; Fiscal Year: 2013
    ..The long term goal is to establish FDA-approved, long acting dopamine agonists as suppressor or PRL secretion, resulting in increased efficacy of chemotherapeutic agents in breast cancer patients. ..
  7. Randomized trial of PEITC as a modifier of NNK metabolism in smokers
    Jian Min Yuan; Fiscal Year: 2012
    ..The major strengths include the need for a randomized, placebo-controlled trial of PEITC, the qualification of the investigators, and the feasibility of the proposed studies. ..
  8. Mitochondrial Oxidative Stress in the Retinal Pigment Epithelium as a Model for A
    Alfred S Lewin; Fiscal Year: 2013
    ..This project seeks to establish a mouse model of the pathology related to AMD and to use this model to test potential therapies for the atrophic form of the disease. ..
  9. Epidemiological Research on Autism in Jamaica
    Mohammad H Rahbar; Fiscal Year: 2010
    ....
  10. Contribution of Gstm1 to the severity of hypertension and chronic kidney disease
    Thu H Le; Fiscal Year: 2013
    ..The relative contribution of the enzymatic and functional non-enzymatic domains of GSTM1 on VSMC proliferation, migration and oxidative stress will also be determined. ..
  11. Mitochondrial function and antifungal photodynamic therapy
    Constantine G Haidaris; Fiscal Year: 2011
    ..abstract_text> ..
  12. Genetic Determinants of Lung Injury
    Beverly H Koller; Fiscal Year: 2013
    ....
  13. Epidemiological Research on Autism in Jamaica - Phase II
    Mohammad H Rahbar; Fiscal Year: 2013
    ....
  14. Chemoprevention of Tamoxifen-induced Endometrial cancer by black cohosh and red c
    BIRGIT MARIA DIETZ; Fiscal Year: 2010
    ..We hypothesize that red clover and black cohosh, both frequently used for the alleviation of menopausal symptoms, will reduce tamoxifen-induced endometrial cancer due to their cancer chemopreventive properties. ..
  15. Diesel, Allergens and Gene Interaction and Child Atopy
    Grace LeMasters; Fiscal Year: 2009
    ....
  16. Genetic Susceptibility Factors in Porphyria Cutanea Tarda (PCT)
    Karl Anderson; Fiscal Year: 2009
    ..This study and projects which follow will lead to a better understanding of PCT and also contribute to knowledge about how agents such as alcohol and hepatitis C interact with genetic factors in causing human liver diseases. ..
  17. Study on the intracellular Network of TBX3
    Taosheng Huang; Fiscal Year: 2010
    ..Elucidation of the TBX3- HDAC interaction will deepen our understanding of the functions of TBX3 and may also lead to the identification of a novel therapeutic target for breast cancer. ..
  18. Cigarette Smoke-derived Electrophilic Aldehydes and Airway Inflammation
    Albert van Der Vliet; Fiscal Year: 2013
    ....
  19. Factors for Epigenetic Silencing of Lung Cancer Genes
    Steven Belinsky; Fiscal Year: 2009
    ..Finally we will describe the gene-specific promoter hypermethylation patterns at study entry and at 18-month follow-up. ..
  20. Detoxification of Electrophilic Chemical Threat Agents by Nucleophilic Scavengers
    Michael C MacLeod; Fiscal Year: 2010
    ..In addition, we will obtain data that indicates whether or not individuals with variants of a particular class of genes, the GSTs, are more susceptible to the effects of SNM toxicants. ..
  21. Cardioprotective Mechanisms of Glutathione S-transferase P
    DANIEL JOSEPH CONKLIN; Fiscal Year: 2012
    ....
  22. ROS, Inflammation, and Cardioprotection in Type 2 Diabetes
    Rakesh C Kukreja; Fiscal Year: 2013
    ..Overall, the proposed studies will pave the way to a potentially novel pharmacotherapy against inflammation and cardiac injuries resulting from T2D conditions. ..
  23. Chemistry, Structure and Biology of Thiol Transferases
    Richard N Armstrong; Fiscal Year: 2013
    ..microsomal prostaglandin E synthase 1 (MPEGS1), 5-lipoxigenase activating protein (FLAP) and microsomal glutathione transferase 1 (MGST1). All of these proteins are integral membrane proteins...
  24. Systemic Chemotherapy of Melanoma: NMR Studies of Lonidamine &N-Mustard Activity
    Jerry D Glickson; Fiscal Year: 2013
    ..3) To evaluate potential 1H NMR markers for noninvasive early detection of response--lactate and total choline by MRS and apparent diffusion constant (ADC) and T2 measured by MRI. ..
  25. Regulation and Function of Adiponectin Oligomerization
    Feng Liu; Fiscal Year: 2012
    ....
  26. Ozone Cardiovascular Effects in Genetically Susceptible People
    MARK WALTER FRAMPTON; Fiscal Year: 2012
    ..Further, subjects with genetic polymorphisms conferring reduced function in glutathione transferase M1 (GSTM1) or nuclear factor erythroid 2- related factor 2 (Nrf2), key regulators of antioxidant defenses,..
  27. Regulation of NF-kappaB in Lung Epithelium by ROS/RNS
    Yvonne M W Janssen-Heininger; Fiscal Year: 2013
    ..Completion of this application will provide new avenues to limit allergic inflammation, and also provide new insights into the anti-inflammatory mechanism of GSTP, which is essentially unknown. ..
  28. GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCES
    Johanna Lampe; Fiscal Year: 2009
    ..abstract_text> ..
  29. Aflatoxin B1 hepatocarcinogenesis in the mGSTA3-/- mouse
    Stewart Sell; Fiscal Year: 2013
    ....
  30. Investigating gene x environment interaction using human exposures to O3 & LPS
    David B Peden; Fiscal Year: 2010
    ..Finally, these studies will also add to fundamental advances in our understanding of the pathophysiology of common human conditions. ..
  31. Protein Kinase C and GSTP1 interactions in glioma drug resistance
    Francis Ali-Osman; Fiscal Year: 2012
    ..The results are likely to lead to novel therapeutic strategies for malignant gliomas, particularly;those characterized by high GSTP1 expression and elevated or highly activated PKCs. ..
  32. A Pilot Study of the DASH Diet in Not-Well-Controlled Adult Asthma
    Jun Ma; Fiscal Year: 2013
    ..It meets NHLBI's funding priority for research to increase the evidence base for refining clinical guidelines and public health recommendations regarding dietary and other lifestyle modifications in asthma. ..
  33. Prostate Cancer Detection by Molecular Urinalysis
    Christian P Pavlovich; Fiscal Year: 2010
    ..Hopefully, useful biomarker information for prostate cancer will also result from my period of study. ..
  34. Developmental Pharmacology of cytosolic and mitochondrial GSTZ1-1/MAAI
    PETER WALLACE STACPOOLE; Fiscal Year: 2013
    ..by applicant): The broad, long-term objectives of this research are to understand the properties of glutathione transferase Z1- 1 (GSTZ1-1) and its role in the elimination of haloacetic acids, particularly dichloroacetic acid (..
  35. Mitochondrial Porin in Bioenergetic Defects in Huntingtons Disease
    Nickolay Brustovetsky; Fiscal Year: 2013
    ....
  36. GENETICS OF MPTP-INDUCED PARKINSONISM
    Richard Smeyne; Fiscal Year: 2009
    ..This identification of GSTp2 as a candidate gene could also lead to the identification of diagnostic measures and point to potential therapies for early intervention in this devastating illness. ..
  37. Protection of Oxidant Toxicity by GSTs
    YOGESH CHANDRA AWASTHI; Fiscal Year: 2010
    ....
  38. P53-dependent GSTP1 Gene Regulation and Glioma Drug Resistance
    Francis Ali-Osman; Fiscal Year: 2013
    ..Investigate the impact of the p53-GSTP1 crosstalk on drug resistance in GBM and examine whether this can be targeted to improve therapeutic efficacy in glioblastoma. ..
  39. Down-regulation of oxidant-induced airway inflammation though modulation of NRF2
    Michelle Hernandez; Fiscal Year: 2013
    ..Angela Kashuba, the director f the clinical pharmacology fellowship at UNC with extensive experience in clinical pharmacokinetic and pharmacodynamic studies. ..
  40. IDENTIFICATION OF TUMOR PROMOTION SUSCEPTIBILITY GENES
    John DiGiovanni; Fiscal Year: 2013
    ..1 and Psl1.3 loci that modify the response to TPA skin tumor promotion. ..
  41. Directed evolution of fosfomycin resistance enzymes from a promiscuous progenitor
    Paul D Cook; Fiscal Year: 2010
    ..Three types of closely related fosfomycin resistance enzymes are known: FosA, a fosfomycin-specific glutathione transferase;FosB, a fosfomycin-specific cysteine transferase;and FosX, a fosfomycin hydrolase...
  42. Glutathione S-Transferase Pi in Age-Related Macular Degeneration
    Wen Hsiang Lee; Fiscal Year: 2013
    ..The proposed studies will utilize clinical ophthalmic diagnosis, immunohistochemistry, Western analysis, as well as electrophysiology. ..
  43. GSTP1 PROMOTER HYPERMETHYLATION IN HUMAN PROSTATE CANCER
    WILLIAM GEORGE NELSON; Fiscal Year: 2012
    ..abstract_text> ..
  44. Glutathione S-Tranferase signaling in VCD-induced ovotoxicity.
    AILEEN FRANCES KEATING; Fiscal Year: 2012
    ..abstract_text> ..
  45. Curcumin inhbits BPDE-induced damage by lowering the threshold of p53 activation
    ERICA NICOLE ROGERS; Fiscal Year: 2011
    ..In addition, the results from this project will benefit the public by providing easy and inexpensive alternative methods in preventing initial and continuing signs of lung cancer. ..
  46. Influence of human gene variants on the effects of developmental MeHg exposure
    Michael J Carvan; Fiscal Year: 2010
    ..2005). If the genetic polymorphisms we are investigating prove to influence sensitivity to developmental MeHg, the societal impact may be dramatically underestimated. ..
  47. DNA methylation in aging, race and prostate cancer
    Rajvir Dahiya; Fiscal Year: 2006
    ..This information can be used for better management of prostate cancer using DNA methylated genes as diagnostic or prognostic biomarkers. ..
  48. Glutathione S-Transferase Functions in Chemoprevention
    Alan Townsend; Fiscal Year: 2009
    ..These studies will enhance our knowledge of the factors that govern chemoprotective functions of GSTs. ..
  49. Advanced GST Proteomics for Early Stage Organ-Specific Toxicity Screening. Phase
    Kevin M Patrie; Fiscal Year: 2013
    ..The cytosolic glutathione transferase (GST) family of enzymes offer a more reliable alternative as a biomarker for organ damage as they exhibit ..
  50. Role of Glia and Inflammation in Altered Synapse Development in Schizophrenia
    SHINICHI KANO; Fiscal Year: 2012
    ..The project will contribute to the understanding of the roles for glial cells and inflammation in altered brain development during adolescence relevant to SZ. ..
  51. SPECIES DIFFERENCE IN THE BIOTRANSFORMATION OF AFLATOXIN
    David Eaton; Fiscal Year: 2003
    ..abstract_text> ..
  52. LIPID PEROXIDATION IN COLORECTAL CANCER
    Manuela Gago Dominguez; Fiscal Year: 2009
    ..4. To conduct a case-case association study to determine if morphological markers of apoptosis in tumor and surrounding free tissue differ among cases with varying exposure levels of a given putative environmental/genetic risk factor. ..
  53. Mildly acidic tumor microenvironment for diagnostic and therapeutic nanomedicine
    JENNICA L KRANKEL; Fiscal Year: 2013
    ..e. proteins and peptides) as anti-cancer therapeutics. ..
  54. Genomic Convergence in Alzheimer Disease
    Margaret A Pericak-Vance; Fiscal Year: 2012
    ..This understanding will be crucial for future studies to develop early interventions and more focused treatments, which will help alleviate the suffering of those with the disease and their families. ..
  55. DETECTION & REVERSAL OF OVARIAN CANCER DRUG RESISTANCE
    Robert Ozols; Fiscal Year: 1992
    ..Results of these Phase I and II trials will lead to additional clinical trials testing the efficacy of combinations of biochemical modulators of resistance (e.g. BSO plus aphidicolin) in drug resistant patients...
  56. ORAL CANCER--DNA POLYMORPHISMS IN CARCINOGEN METABOLISM
    Stephen Schwartz; Fiscal Year: 2001
    ....
  57. ROLE OF HUMAN GST PI POLYMORPHISM IN DRUG RESISTANCE
    Shivendra Singh; Fiscal Year: 2003
    ..These studies, in the long term, may be valuable in identifying subjects that may be at a higher risk for developing GST-mediated resistance to some alkylating agents. ..
  58. Halogenated Alkenes and Microsomal GSH-transferases
    Michael J Kelner; Fiscal Year: 2010
    ..effects of vicinal haloalkenes stems from their conversion in hepatic microsomes by the enzyme microsomal glutathione transferase-1 (MGST1) to GSH S-conjugates, which are transported to intestine and then converted to the corresponding ..
  59. COLLABORATIVE CENTER FOR AN ENZYME FUNCTION INITIATIVE
    John A Gerlt; Fiscal Year: 2013
    ..by five Bridging Projects that focus on the functionally diverse amidohydrolase (AH), enolase (EN), glutathione transferase (GST), haloalkanoic acid dehalogenase (HAD), and isoprenoid synthase (IS) superfamilies...
  60. GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCES
    Johanna Lampe; Fiscal Year: 2006
    ..abstract_text> ..
  61. GLUTATHIONE S-TRANSFERASE INDUCTION BY TOXICANTS
    Raymond Novak; Fiscal Year: 1993
    ..This research will provide information on the GSTs induced by the nitrogen heterocycles and regulatory mechanism(s) which govern GST induction-an area of considerable importance given the multifunctional role of the GSTs...
  62. GENE EXPRESSION IN XENOBIOTICS METABOLISM
    CHEN PEI TU; Fiscal Year: 1999
    ..Results from this study should enhance the overall understanding of the effects of xenobiotics in modulating mammalian and human gene activities, especially those encoding the xenobiotic metabolizing enzymes. ..
  63. METABOLISM AND TOXICITY OF HALOGENATED HYDROCARBONS
    MARION ANDERS; Fiscal Year: 2004
    ..This competitive renewal application will be focused on the glutathione transferase zeta (GSTZ 1-1)-catalyzed metabolism of a-haloacids, particularly dichloroacetate (DCA)...
  64. Activation of the Cancer Preventive Nrf2-ARE Pathway by Seaweed
    Hendrik Luesch; Fiscal Year: 2009
    ..The identification of cancer-preventing seaweeds and of individual active components may become the basis for the development of new health-promoting strategies. ..
  65. Reactivation of GSTP1 Gene by Green Tea Polyphenols
    Sanjay Gupta; Fiscal Year: 2005
    ..abstract_text> ..
  66. ENZYME INDUCTION DEFECT--IMPLICATION FOR TOXICITY
    Robert Blouin; Fiscal Year: 1992
    ..be limited to the PB- inducible isozymes of cytochrome P-450 (P-450 + P-450e) since other enzymes, namely glutathione transferase and apolipoprotein A-1, respond to PB-treatment...
  67. LIVER SPECIFIC, INDUCIBLE TRANSGENE AND HEPATOTOXICITY
    Tsonwin Hai; Fiscal Year: 2000
    ..The effects of aberrant ATF-transgene expression on liver function will also be examined during embryonic development. ..