sterol o acyltransferase

Summary

Summary: An enzyme that catalyzes the formation of cholesterol esters by the direct transfer of the fatty acid group from a fatty acyl CoA derivative. This enzyme has been found in the adrenal gland, gonads, liver, intestinal mucosa, and aorta of many mammalian species. EC 2.3.1.26.

Top Publications

  1. ncbi ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization
    S Cases
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141, USA
    J Biol Chem 273:26755-64. 1998
  2. ncbi Effect of ACAT inhibition on the progression of coronary atherosclerosis
    Steven E Nissen
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 354:1253-63. 2006
  3. ncbi Peroxisome proliferator-activated receptor alpha reduces cholesterol esterification in macrophages
    G Chinetti
    UR 545 INSERM, Institut Pasteur de Lille and Université de Lille 2, Lille, France
    Circ Res 92:212-7. 2003
  4. ncbi Dietary fatty acids regulate acyl-CoA:cholesterol acyltransferase and cytosolic cholesteryl ester hydrolase in hamsters
    Ji Young Lee
    Department of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE 68583, USA
    J Nutr 134:3239-44. 2004
  5. ncbi Induction of acyl-coenzyme A:cholesterol acyltransferase-1 by 1,25-dihydroxyvitamin D(3) or 9-cis-retinoic acid in undifferentiated THP-1 cells
    K Maung
    Department of Biochemistry, Kumamoto University School of Medicine, 2-2-1 Honjo, Kumamoto 860-0811, Japan
    J Lipid Res 42:181-7. 2001
  6. ncbi ACAT inhibition and progression of carotid atherosclerosis in patients with familial hypercholesterolemia: the CAPTIVATE randomized trial
    Marijn C Meuwese
    Department of Vascular Medicine, Academic Medical Center, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    JAMA 301:1131-9. 2009
  7. ncbi Effects of the acyl coenzyme A:cholesterol acyltransferase inhibitor avasimibe on human atherosclerotic lesions
    Jean Claude Tardif
    Montreal Heart Institute, 5000 Belanger St, Montreal, H1T 1C8, Canada
    Circulation 110:3372-7. 2004
  8. ncbi Differential modulation of ACAT1 and ACAT2 transcription and activity by long chain free fatty acids in cultured cells
    T Seo
    Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, 630W 168th Street PH1512, New York, New York 10032, USA
    Biochemistry 40:4756-62. 2001
  9. ncbi Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro
    P J Uelmen
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 270:26192-201. 1995
  10. ncbi Expression of scavenger receptor BI facilitates sterol movement between the plasma membrane and the endoplasmic reticulum in macrophages
    Z Hua Huang
    Department of Medicine, Rush Presbyterian Saint Luke s Medical Center, 1653 West Congress Parkway, Chicago, Illinois 60612, USA
    Biochemistry 42:3949-55. 2003

Detail Information

Publications189 found, 100 shown here

  1. ncbi ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization
    S Cases
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141, USA
    J Biol Chem 273:26755-64. 1998
    ..The identification and cloning of ACAT-2 will facilitate molecular approaches to understanding the role of ACAT enzymes in mammalian biology...
  2. ncbi Effect of ACAT inhibition on the progression of coronary atherosclerosis
    Steven E Nissen
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 354:1253-63. 2006
    ..The enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT) esterifies cholesterol in a variety of tissues. In some animal models, ACAT inhibitors have antiatherosclerotic effects...
  3. ncbi Peroxisome proliferator-activated receptor alpha reduces cholesterol esterification in macrophages
    G Chinetti
    UR 545 INSERM, Institut Pasteur de Lille and Université de Lille 2, Lille, France
    Circ Res 92:212-7. 2003
    ..In conclusion, our results identify a role for PPARalpha in the control of cholesterol esterification in macrophages, resulting in an enhanced availability of FC for efflux through the ABCA1 pathway...
  4. ncbi Dietary fatty acids regulate acyl-CoA:cholesterol acyltransferase and cytosolic cholesteryl ester hydrolase in hamsters
    Ji Young Lee
    Department of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE 68583, USA
    J Nutr 134:3239-44. 2004
    ..The data suggest that cholesterolemic effects of individual dietary fatty acids can be achieved through their independent modulation of pathways regulating assembly and secretion of apoB(100)-containing particles...
  5. ncbi Induction of acyl-coenzyme A:cholesterol acyltransferase-1 by 1,25-dihydroxyvitamin D(3) or 9-cis-retinoic acid in undifferentiated THP-1 cells
    K Maung
    Department of Biochemistry, Kumamoto University School of Medicine, 2-2-1 Honjo, Kumamoto 860-0811, Japan
    J Lipid Res 42:181-7. 2001
    ..0-fold by using 100 nM 1,25-(OH)(2)D(3), and 1.8-fold by using 1 microM 9-cis-RA. Together, our results suggest that 1,25-(OH)(3) participates in ACAT-1 gene expression during the monocyte-macrophage differentiation process...
  6. ncbi ACAT inhibition and progression of carotid atherosclerosis in patients with familial hypercholesterolemia: the CAPTIVATE randomized trial
    Marijn C Meuwese
    Department of Vascular Medicine, Academic Medical Center, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    JAMA 301:1131-9. 2009
    ..Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT), an intracellular enzyme involved in cholesterol accumulation, with pactimibe was developed to assist in the prevention of cardiovascular disease...
  7. ncbi Effects of the acyl coenzyme A:cholesterol acyltransferase inhibitor avasimibe on human atherosclerotic lesions
    Jean Claude Tardif
    Montreal Heart Institute, 5000 Belanger St, Montreal, H1T 1C8, Canada
    Circulation 110:3372-7. 2004
    ..The ACAT inhibitor avasimibe was shown to reduce experimental atherosclerosis. This study was designed to investigate the effects of avasimibe on human coronary atherosclerosis...
  8. ncbi Differential modulation of ACAT1 and ACAT2 transcription and activity by long chain free fatty acids in cultured cells
    T Seo
    Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, 630W 168th Street PH1512, New York, New York 10032, USA
    Biochemistry 40:4756-62. 2001
    ..In contrast, HepG2 and ACAT2 microsomes utilized linolenoyl CoA as well. We conclude that FFAs increase ACAT1 mRNA levels in a cell specific manner, and furthermore that the ACAT reactions exhibit differential FFA utilization...
  9. ncbi Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro
    P J Uelmen
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 270:26192-201. 1995
    ..Two transfected Chinese hamster ovary cell lines that expressed the mouse ACAT transgene regained the ability to esterify cholesterol.(ABSTRACT TRUNCATED AT 250 WORDS)..
  10. ncbi Expression of scavenger receptor BI facilitates sterol movement between the plasma membrane and the endoplasmic reticulum in macrophages
    Z Hua Huang
    Department of Medicine, Rush Presbyterian Saint Luke s Medical Center, 1653 West Congress Parkway, Chicago, Illinois 60612, USA
    Biochemistry 42:3949-55. 2003
    ..It is concluded that expression of SR-BI in macrophages increases the rate of free cholesterol transport, and modulates free cholesterol distribution between the plasma membrane and the internal membrane compartments in macrophages...
  11. ncbi LDL cholesteryl oleate: a biomarker for atherosclerosis?
    Arthur A Spector
    Arterioscler Thromb Vasc Biol 27:1228-30. 2007
  12. pmc A role for smooth endoplasmic reticulum membrane cholesterol ester in determining the intracellular location and regulation of sterol-regulatory-element-binding protein-2
    C R Iddon
    Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK
    Biochem J 358:415-22. 2001
    ....
  13. ncbi Effect of F-1394, an acyl-CoA:cholesterol acyltransferase inhibitor, on atherosclerosis induced by high cholesterol diet in rabbits
    K Aragane
    Pharmaceutical Research Laboratories, Fujirebio Inc, 51 Komiya-cho, Hachioji, Tokyo 192-0031, Japan
    Atherosclerosis 158:139-45. 2001
    ..These results demonstrate that F-1394 both prevents the formation of atherosclerosis and accelerates its regression without affecting the serum TC level, indicating that F-1394 acts directly on the arterial wall...
  14. ncbi Effects of gamma-irradiated fats on plasma lipid concentrations and hepatic cholesterol metabolism in rats
    E Kim
    Department of Food Science and Nutrition, Kyungpook National University, Taegu, South Korea
    Ann Nutr Metab 45:152-8. 2001
    ..These results indicate that although slight changes in the lipid metabolism were observed as a result of 5-kGy-gamma-irradiated fat feeding, they were relative to the fat type and had no harmful consequences...
  15. ncbi Impact of an enriched-cholesterol diet on enzymatic cholesterol metabolism during rabbit gestation
    Alain Montoudis
    Laboratoire de Physiologie Materno Foetale, Universite du Quebec a Montreal, Montreal, Canada H3C 3P8
    Life Sci 73:1463-77. 2003
    ..Gestation associated with ECD reduces significantly the HMG-CoA-reductase activity, decreasing the cholesterol synthesis, but placenta seems to compensate this effect by increasing its HMG-CoA-reductase activity...
  16. ncbi Hypocholesterolemic and antioxidant properties of 3-(4-hydroxyl)propanoic acid derivatives in high-cholesterol fed rats
    Mi Kyung Lee
    Department of Food and Nutrition, Sunchon National University, Jeonnam, Republic of Korea
    Chem Biol Interact 170:9-19. 2007
    ..These results suggest that two cinnamic acid synthetic derivatives (HPP304 and HPP305) exert lipid-lowering action and antioxidant properties without hepatotoxicity in high-cholesterol fed rats...
  17. ncbi Pharmacological profile of SMP-797, a novel acyl-coenzyme a: cholesterol acyltransferase inhibitor with inducible effect on the expression of low-density lipoprotein receptor
    Katsuhisa Ioriya
    Research Division, Sumitomo Pharmaceuticals Co, Ltd, Osaka, Japan
    J Cardiovasc Pharmacol 47:322-9. 2006
    ....
  18. ncbi Protective effect of simvastatin and VULM 1457 in ischaemic-reperfused myocardium of the diabetic-hypercholesterolemic rats
    A ADAMEOVA
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic
    Pharmazie 61:807-8. 2006
    ..01). Simvastatin and VULM 1457 with the shown hypolipidemic effect, significantly (p < 0.01) suppressed a formation of VF (38% and 29%; respectively)...
  19. ncbi Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A:Cholesterol Acyltransferase (ACAT)
    Jennifer A Locke
    Department of Urologic Sciences, University of British Columbia, The Prostate Centre at Vancouver General Hospital, Vancouver, British Columbia, Canada
    Prostate 68:20-33. 2008
    ..The objective of this work was to determine the effect of an androgen agonist, R1881, on intracellular cholesterol synthesis and esterification in androgen-sensitive (AS) prostate cancer (LNCaP) cells...
  20. ncbi Overexpression of CYP27 in hepatic and extrahepatic cells: role in the regulation of cholesterol homeostasis
    E Hall
    Department of Medicine, Medical College of Virginia, Virginia Commonwealth University and McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249, USA
    Am J Physiol Gastrointest Liver Physiol 281:G293-301. 2001
    ..02) and decreased cholesteryl ester hydrolase (55%, P < or = 0.02). In conclusion, CYP27 generates different physiological responses depending on cell type and presence or absence of bile acid biosynthetic pathways...
  21. ncbi Acyl-coenzyme A:cholesterol acyltransferase inhibition ameliorates proteinuria, hyperlipidemia, lecithin-cholesterol acyltransferase, SRB-1, and low-denisty lipoprotein receptor deficiencies in nephrotic syndrome
    N D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, USA
    Circulation 110:419-25. 2004
    ..Because hepatic ACAT-2 is markedly upregulated in NS, we tested the hypothesis that inhibition of ACAT may improve cholesterol metabolism in NS...
  22. ncbi Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP
    L J Wilcox
    Departments of Medicine and Biochemistry and The John P. Robarts Research Institute, 4-16, University of Western Ontario, 100 Perth Drive, London, Ontario N6A 5K8, Canada
    J Lipid Res 42:725-34. 2001
    ..Together with an enhanced expression of the LDL receptor, these mechanisms may explain the hypocholesterolemic properties of the citrus flavonoids...
  23. ncbi Effects of high-density lipoprotein(2) on cholesterol transport and acyl-coenzyme A:cholesterol acyltransferase activity in P388D1 macrophages
    L Li
    Department of Medicine and the Cardiovascular Sciences Graduate Program of the DeBakey Heart Center, Baylor College of Medicine and The Methodist Hospital, Houston, TX 77030, USA
    Biochim Biophys Acta 1530:111-22. 2001
    ..Elucidation of the mechanism by which HDL(2) inhibits ACAT could identify new therapeutic targets that enhance the transfer of cholesterol from macrophages to the liver...
  24. ncbi Effects of dietary soybean lecithin on plasma lipid transport and hepatic cholesterol metabolism in rats
    Marie Josée Leblanc
    Department of Nutrition, Universite de Montreal, Montreal, Quebec, Canada
    J Nutr Biochem 14:40-8. 2003
    ....
  25. ncbi Cholesterol absorption and hepatic acyl-coenzyme A:cholesterol acyltransferase activity play major roles in lipemic response to dietary cholesterol and fat in laboratory opossums
    Rampratap S Kushwaha
    Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Metabolism 53:817-22. 2004
    ..Cholesterol absorption is a major determinant of diet-induced hyperlipidemia in opossums. Hepatic ACAT activity but not the intestinal ACAT may also play a role in diet-induced hyperlipidemia in opossums...
  26. ncbi The aromatase knockout mouse presents with a sexually dimorphic disruption to cholesterol homeostasis
    Kylie N Hewitt
    Prince Henry s Institute of Medical Research and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Endocrinology 144:3895-903. 2003
    ..This study reveals a sexually dimorphic difference in mouse hepatic cholesterol homeostasis and roles for estrogen in the regulation of cholesterol uptake, biosynthesis, and catabolism in the female, but not in the male...
  27. ncbi [Effect of stimulation and inhibition of macrophage functions on hypercholesterolemia in rats]
    P O Kuznetsov
    Institute of Internal Medicine, Siberian Division of the Russian Academy of Medical Sciences, Vladimirovski st 2a, Novosibirsk 630003, Russia
    Vopr Med Khim 48:180-8. 2002
    ..The data obtained suggest that the stimulation of mononuclear phagocyte system may lead to a decrease of plasma C via activation of LDL and VLDL catabolism and induction of bile acid synthesis in liver...
  28. ncbi Naringin time-dependently lowers hepatic cholesterol biosynthesis and plasma cholesterol in rats fed high-fat and high-cholesterol diet
    So Yeon Kim
    Department of Nutrition Care Services, Seoul National University Bundang Hospital, Gyeonggi Do, Republic of Korea
    J Med Food 9:582-6. 2006
    ..Naringin can, however, be beneficial for lowering hepatic cholesterol biosynthesis and levels of plasma lipids when supplemented for 6 weeks in this animal model...
  29. ncbi 17beta-estradiol enhances the flux of cholesterol through the cholesteryl ester cycle in human macrophages
    M Napolitano
    Laboratory of Metabolism and Pathological Biochemistry, Istituto Superiore di Sanita, Rome, Italy
    Biosci Rep 21:637-52. 2001
    ....
  30. ncbi Effect of taurine on cholesterol metabolism in hamsters: up-regulation of low density lipoprotein (LDL) receptor by taurine
    Shigeru Murakami
    Medicinal Research Laboratories, Taisho Pharmaceutical Co, Ltd, Saitama, Japan
    Life Sci 70:2355-66. 2002
    ..Thus, up-regulation of the LDL receptor and subsequent increase in receptor- mediated LDL turnover may be a key event in the cholesterol-lowering effects of taurine in hamsters...
  31. ncbi Primates highly responsive to dietary cholesterol up-regulate hepatic ACAT2, and less responsive primates do not
    Lawrence L Rudel
    Arteriosclerosis Research Program, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 277:31401-6. 2002
    ..Regulation of ACAT2 gene transcription was not a factor...
  32. ncbi Selective uptake from LDL is stimulated by unsaturated fatty acids and modulated by cholesterol content in the plasma membrane: role of plasma membrane composition in regulating non-SR-BI-mediated selective lipid transfer
    Toru Seo
    Institute of Human Nutrition and Department of Pediatrics, Columbia University, New York, NY 10032, USA
    Biochemistry 41:7885-94. 2002
    ..Moreover, in conditions where elevated plasma FFA occur, SU from LDL can be an important mechanism for cholesterol delivery in vivo...
  33. ncbi Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay: individual ACAT uniqueness
    Aaron T Lada
    Department of Pathology, Arteriosclerosis Research Program, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Lipid Res 45:378-86. 2004
    ....
  34. ncbi Anti-atherosclerotic effect of a new synthetic functional oil containing mono- and diacylglycerol from corn oil
    Kyung Hyun Cho
    School of Biotechnology, Yeungnam University, Gyeongsan, South Korea
    Ann Nutr Metab 50:467-75. 2006
    ..These results indicate that the FO possesses a blood cholesterol-lowering effect in mouse model and inhibition effects against the atherogenic enzymes...
  35. ncbi Effect of SMP-500, a novel acyl-coA:cholesterol acyltransferase inhibitor, on the cholesterol esterification and its hypocholesterolemic properties
    K Ioriya
    Research Division, Sumitomo Pharmaceuticals Co, Ltd, Osaka, Japan
    Pharmacology 65:18-25. 2002
    ..These results indicate that SMP-500 is a potent and competitive ACAT inhibitor and may have a therapeutic potential for treating hypercholesterolemia and atherosclerosis...
  36. ncbi Liver-specific inhibition of acyl-coenzyme a:cholesterol acyltransferase 2 with antisense oligonucleotides limits atherosclerosis development in apolipoprotein B100-only low-density lipoprotein receptor-/- mice
    Thomas A Bell
    Department of Pathology, Section on Lipid Sciences, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
    Arterioscler Thromb Vasc Biol 26:1814-20. 2006
    ..The purpose of this study was to determine the effects of liver-specific inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) on the development of hypercholesterolemia and atherosclerosis in mice...
  37. ncbi Hypocholesterolaemic effects of an ethanol precipitate of Kabosu juice in stroke-prone spontaneously hypertensive rats fed a cholesterol-free diet
    Hiroshi Ogawa
    Department of Hygiene, Kinki University School of Medicine, Osaka Sayama City, Osaka and Faculty of Education and Welfare Science, Oita University, Oita City, Oita, Japan
    Clin Exp Pharmacol Physiol 30:532-6. 2003
    ....
  38. ncbi Apoptosis and plaque destabilization in atherosclerosis: the role of macrophage apoptosis induced by cholesterol
    I Tabas
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Cell Death Differ 11:S12-6. 2004
  39. ncbi Hawthorn fruit is hypolipidemic in rabbits fed a high cholesterol diet
    Zesheng Zhang
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, The People s Republic of China
    J Nutr 132:5-10. 2002
    ..05). The results suggest that the mechanism by which hawthorn fruit decreases serum cholesterol involves, at least in part, the inhibition of cholesterol absorption mediated by down-regulation of intestinal ACAT activity...
  40. ncbi Hypolipidemic and antioxidant activity of the novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor KY-455 in rabbits and hamsters
    Shohei Nakamura
    Research Laboratories, Kyoto Pharmaceutical Industries, Ltd, Kyoto, Japan
    Arzneimittelforschung 54:102-8. 2004
    ..Long-term administration of KY-455 is expected to prevent the progress of atherosclerosis by lowering plasma lipid levels, inhibiting both LDL-oxidation and accumulation of cholesterol in macrophages...
  41. ncbi The hypolipidemic effect of a new ACAT inhibitor, VULM 1457, in diabetic-hypercholesterolaemic rats
    A ADAMEOVA
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic
    Pharmazie 60:714-5. 2005
    ..VULM 1457, with a slight influence on triglyceride levels, significantly reduced plasma and hepatic cholesterol concentrations (p < 0.05, p < 0.001; respectively) in the diabetic-hypercholesterolaemic rats...
  42. ncbi Effect of SMP-500, a novel ACAT inhibitor, on hepatic cholesterol disposition in rats
    Katsuhisa Ioriya
    Research Division, Sumitomo Pharmaceuticals Co Ltd, Osaka, Japan
    Lipids 37:395-400. 2002
    ..SMP-500 reduced the serum TG level in sucrose-fed rats. From these results, one may hypothesize that the suppression of hepatic VLDL secretion probably plays an important role on both cholesterol- and TG-lowering effects of SMP-500...
  43. pmc Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals
    V L Meiner
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94110, USA
    Proc Natl Acad Sci U S A 93:14041-6. 1996
    ..These tissue-specific reductions in cholesterol esterification provide evidence that in mammals this process involves more than one form of esterification enzyme...
  44. ncbi Altered lipid metabolism in apolipoprotein E-deficient mice does not affect cholesterol balance across the liver
    F Kuipers
    Groningen Institute for Drug Studies, Laboratory of Nutrition and Metabolism, Academic Hospital Groningen, The Netherlands
    Hepatology 24:241-7. 1996
    ..The data are compatible with increased peripheral cholesterol biosynthesis in apoE-deficient mice...
  45. ncbi Effect of 3,4-di(OH)-cinnamate synthetic derivative on plasma and hepatic cholesterol level and antioxidant enzyme activities in high cholesterol-fed rats
    Eun Jin Park
    Department of Food Science and Nutrition, Kyungpook National University, 702 701 Daegu, Korea
    J Biochem Mol Toxicol 18:279-87. 2004
    ..Accordingly, the current results suggest that SL-1063, a synthetic derivative of 3,4-di(OH)-cinnamate, is effective in lowering the plasma lipids and improving the antioxidant enzyme system...
  46. ncbi Effect of lupeol and lupeol linoleate on lipemic--hepatocellular aberrations in rats fed a high cholesterol diet
    Varatharajan Sudhahar
    Department of Medical Biochemistry, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India
    Mol Nutr Food Res 50:1212-9. 2006
    ..Therefore, it can be concluded that triterpenes treatment afforded substantial protection against the anomalies, which are manifested during the early stage of hypercholesterolemic atherogenesis...
  47. ncbi The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1
    M Miyazaki
    Departments of Biochemistry and Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 275:30132-8. 2000
    ....
  48. pmc Inhibition of acyl-coenzyme A:cholesterol acyltransferase stimulates cholesterol efflux from macrophages and stimulates farnesoid X receptor in hepatocytes
    Sojin An
    National Research Laboratory of Lipid Metabolism and Atherosclerosis, KRIBB, Daejeon, Korea
    Exp Mol Med 40:407-17. 2008
    ....
  49. ncbi Anti-obesity and hypolipidemic effects of a proprietary herb and fiber combination (S&S PWH) in rats fed high-fat diets
    Myoung Nam Woo
    Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea
    J Med Food 11:169-78. 2008
    ..89 g/100 g) in the S&S PWH. In conclusion, these results suggest that S&S PWH can be considered as an anti-obesity functional formula that is effective for suppressing body weight gain and enhancing lipid profile...
  50. ncbi Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential
    Richard G Lee
    Arteriosclerosis Research Program, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Circ Res 95:998-1004. 2004
    ..Overall, the data suggest that ACAT2-derived CE is the predominant atherogenic lipid in blood, and that an important goal for prevention of atherosclerosis is to limit ACAT2-derived CE accumulation in lipoproteins...
  51. ncbi ACAT inhibitor F-1394 prevents intimal hyperplasia induced by balloon injury in rabbits
    K Aragane
    Central Research Laboratories, Fujirebio Inc, 51 Komiya-cho, Hachioji, Tokyo 192-0031, Japan
    J Lipid Res 42:480-8. 2001
    ....
  52. ncbi ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver
    Paolo Parini
    Metabolism Unit, Center for Metabolism and Endocrinology, Department of Medicine, Novum, Karolinska Institute at Huddinge University Hospital, Huddinge, Sweden
    Circulation 110:2017-23. 2004
    ..Two acyl-coenzyme A:cholesterol acyltransferase (ACAT) genes, ACAT1 and ACAT2, have been identified that encode 2 proteins responsible for intracellular cholesterol esterification...
  53. ncbi Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits
    Seon Min Jeon
    Department of Nutrition and Food Science, Kyungpook National University, 1370 Sankyuk Dong Puk ku, 702 701, Daegu 702 701, South Korea
    Clin Nutr 23:1025-34. 2004
    ..Hyperlipidemia is a major risk factor for cardiovascular diseases. This study was designed to confirm the hypocholesterolemic role of naringin...
  54. ncbi Characteristics of mRNA levels of hepatic key enzymes in cholesterol metabolism of genetically gallstone-susceptible mice
    Guo Qiang Xu
    Department of Gastroenterology, First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou 310003, China
    Chin Med J (Engl) 117:1259-61. 2004
  55. pmc Cholesterol synthesis inhibition elicits an integrated molecular response in human livers including decreased ACAT2
    Paolo Parini
    Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 28:1200-6. 2008
    ..The purpose of this study was to identify how different degrees of cholesterol synthesis inhibition affect human hepatic cholesterol metabolism...
  56. ncbi Dietary fat saturation effects on low-density-lipoprotein concentrations and metabolism in various animal models
    R J Nicolosi
    Department of Health and Clinical Sciences, University of Massachusetts Lowell 01854, USA
    Am J Clin Nutr 65:1617S-1627S. 1997
    ..Stearic acid (18:0) appears to be neutral in its LDL-C-raising potential and how it affects LDL metabolism...
  57. ncbi Sex and hormonal status influence plasma lipid responses to psyllium
    S Vega-Lopez
    Department of Nutritional Sciences, University of Connecticut, Storrs 06269, USA
    Am J Clin Nutr 74:435-41. 2001
    ..The primary mechanisms by which soluble fiber lowers plasma cholesterol are well known. However, specific effects of fiber on lipoprotein metabolism and how sex and hormonal status influence these effects are not well defined...
  58. pmc Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice
    Zhiguang Su
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Lipid Res 50:116-25. 2009
    ..5, 6.3, 2.6, 1.1, and 0.6 Mb, respectively. These data will serve as a reference for any effort to test the impact of candidate genes on HDL using a knockout strategy...
  59. ncbi Influence of genetic polymorphisms on responsiveness to dietary fat and cholesterol
    S Q Ye
    Lipid Research Atherosclerosis Division, Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Clin Nutr 72:1275S-1284S. 2000
    ....
  60. ncbi High plasma lecithin:cholesterol acyltransferase activity does not predict low incidence of cardiovascular events: possible attenuation of cardioprotection associated with high HDL cholesterol
    Robin P F Dullaart
    Department of Endocrinology, University of Groningen and University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Atherosclerosis 208:537-42. 2010
    ..001). These HRs were unchanged after non-HDL cholesterol and triglyceride adjustment. In conclusion, high plasma LCAT activity does not predict reduced CVD risk, and may attenuate cardioprotection associated with higher HDL cholesterol...
  61. ncbi ACAT1 deletion in murine macrophages associated with cytotoxicity and decreased expression of collagen type 3A1
    Annabelle Rodriguez
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Biochem Biophys Res Commun 331:61-8. 2005
    ..02). Thus, ACAT1 KO macrophages show biochemical changes consistent with increased cytotoxicity and also a novel association with decreased expression of collagen type 3A1...
  62. ncbi Preparation of an anti-Cdx-2 antibody for analysis of different species Cdx-2 binding to acat2 promoter
    Bao Liang Song
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai 200031, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:6-12. 2003
    ....
  63. ncbi Inhibition of acyl-CoA cholesterol acyltransferase by F12511 (Eflucimibe): could it be a new antiatherosclerotic therapeutic?
    Antonio José López-Farré
    Cardiovascular Research Unit, Cardiovascular Institute, Hospital Clinico San Carlos, Madrid, Spain
    Cardiovasc Ther 26:65-74. 2008
    ..A considerable interest to develop ACAT inhibitors has been emerging. This review has been focused on the current knowledge about a new ACAT inhibitor, F12511 or eflucimibe, and more particularly on its antiatherosclerotic properties...
  64. ncbi The disulfide linkage and the free sulfhydryl accessibility of acyl-coenzyme A:cholesterol acyltransferase 1 as studied by using mPEG5000-maleimide
    Zhan Yun Guo
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Biochemistry 44:6537-46. 2005
    ..The results show that C92 is located on the cytoplasmic side of the ER membrane and the disulfide is located in the ER lumen, while all other free Cs are located within the hydrophobic region(s) of the enzyme...
  65. ncbi Acyl-coenzyme A:cholesterol acyltransferase inhibitors for controlling hypercholesterolemia and atherosclerosis
    Akira Miyazaki
    Department of Biochemistry, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Curr Opin Investig Drugs 4:1095-9. 2003
    ..Thus, ACAT inhibitors are under investigation for controlling hypercholesterolemia and the development of atherosclerosis. Some potent ACAT inhibitors have been tested for their efficacy and safety in humans...
  66. ncbi Coordinated alteration of hepatic gene expression in fatty acid and triglyceride synthesis in LCAT-null mice is associated with altered PUFA metabolism
    Hui Song
    Department of Medicine, St Michael s Hospital, Toronto, ON M5B 1A6, Canada
    Am J Physiol Endocrinol Metab 290:E17-E25. 2006
    ..Some of the phenotypes are not readily explained by known mechanisms and may represent novel regulatory pathways...
  67. ncbi Interaction of fluorescent delta 5,7,9(11),22-ergostatetraen-3 beta-ol with sterol carrier protein-2
    F Schroeder
    Department of Pharmacology, College of Pharmacy, University of Cincinnati, Ohio 45267 0004
    J Biol Chem 265:151-7. 1990
    ..These results demonstrate the utility of dehydroergosterol to probe SCP-2 interactions with sterols and are indicative of a physiological role for SCP-2 as a soluble sterol carrier...
  68. ncbi Dietary fat-induced alterations in atherosclerosis are abolished by ACAT2-deficiency in ApoB100 only, LDLr-/- mice
    Thomas A Bell
    Wake Forest University School of Medicine, Department of Pathology Lipid Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
    Arterioscler Thromb Vasc Biol 27:1396-402. 2007
    ..We hypothesized that when ACAT2 activity is removed by gene deletion, hepatic CE synthesis and secretion would be minimal and, as a result, dietary fat-related differences in atherosclerosis would be eliminated...
  69. ncbi Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains
    S Lin
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 274:23276-85. 1999
    ..The results show that human ACAT-1 in the ER contains seven transmembrane domains...
  70. ncbi Anti-atherosclerotic properties of the acyl-coenzyme A:cholesterol acyltransferase inhibitor F 12511 in casein-fed New Zealand rabbits
    Yves Rival
    Centre de Recherche Pierre Fabre, Castres, France
    J Cardiovasc Pharmacol 39:181-91. 2002
    ....
  71. ncbi Isolation and characterization of human apolipoprotein A-I Fukuoka (110 Glu----Lys). A novel apolipoprotein variant
    Y Takada
    Department of Internal Medicine, Fukuoka University School of Medicine, Japan
    Biochim Biophys Acta 1043:169-76. 1990
    ..This mutant apolipoprotein A-I has much the same potential as to activate lecithin-cholesterol acyltransferase...
  72. ncbi Effects of HMG-CoA reductase inhibition on hepatic expression of key cholesterol-regulatory enzymes and receptors in nephrotic syndrome
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, Orange, Calif 92868, USA
    Am J Nephrol 24:606-13. 2004
    ..This study was carried out to discern the effect of inhibition of HMG-CoA reductase on expression of the key enzymes and receptors involved in cholesterol metabolism in the liver...
  73. ncbi Anticholesterolemic effect of 3,4-di(OH)-phenylpropionic amides in high-cholesterol fed rats
    Soon ja Kim
    Department of Food Science and Nutrition, Kyungpook National University, 702 701 Daegu, South Korea
    Toxicol Appl Pharmacol 208:29-36. 2005
    ..Accordingly, the current results suggest that E030 and E076, two amide synthetic derivatives of HC, are effective in lowering lipid activity...
  74. ncbi Inhibitory effect of monatepil maleate on acyl-CoA:cholesterol acyltransferase activity in the liver of cholesterol-fed Japanese monkeys
    T Sumiya
    Department of Pharmacology I, Dainippon Pharmaceutical Co, Ltd, Suita, Osaka, Japan
    Am J Hypertens 10:779-85. 1997
    ..765, P < .0001) and to plasma total cholesterol content (r = 0.573, P < .005) in the monkeys. These results suggest that ACAT-inhibiting effect of monatepil maleate plays an important role in the reduction of hyperlipidemia...
  75. ncbi The effect of inhibition of acyl coenzyme A-cholesterol acyltransferase (ACAT) on exercise performance in patients with peripheral arterial disease
    William R Hiatt
    Section of Vascular Medicine, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Vasc Med 9:271-7. 2004
    ....
  76. ncbi Cellular sterol ester synthesis in plants is performed by an enzyme (phospholipid:sterol acyltransferase) different from the yeast and mammalian acyl-CoA:sterol acyltransferases
    Antoni Banas
    Department of Crop Science, Swedish University of Agricultural Sciences, P O Box 44, SE 230 53 Alnarp, Sweden
    J Biol Chem 280:34626-34. 2005
    ..Thus, PSAT has a similar physiological function in plant cells as the unrelated acyl-CoA:sterol acyltransferase has in animal cells...
  77. ncbi Triterpenoids from the flower of Campsis grandiflora K. Schum. as human acyl-CoA: cholesterol acyltransferase inhibitors
    Dong Hyun Kim
    Graduate School of Biotechnology and Plant Metabolism Research Center, Kyung Hee University, Suwon 449 701, Korea
    Arch Pharm Res 28:550-6. 2005
    ..Also, compounds 4, 5, 6, and 7 revealed relatively high hACAT-1 inhibitory activity with the value of 46.2+/-1.1, 46.7+/-0.9, 41.5+/-1.3 and 60.8+/-1.1% at the concentration of 100 microg/mL, respectively...
  78. ncbi Control of ACAT2 liver expression by HNF1
    Camilla Pramfalk
    Metabolism Unit, Center for Metabolism and Endocrinology, Novum, Karolinska Institutet at Karolinska University Hospital in Huddinge, S 141 86 Stockholm, Sweden
    J Lipid Res 46:1868-76. 2005
    ....
  79. ncbi Insights into unique physiological features of neutral lipids in Apicomplexa: from storage to potential mediation in parasite metabolic activities
    Isabelle Coppens
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 2223, USA
    Int J Parasitol 35:597-615. 2005
    ..The second part of the review focuses on rhoptry cholesterol and its potential roles in the biogenesis, structural organisation and function of these unique organelles among eukaryotes...
  80. ncbi Peptides derived from serum amyloid A prevent, and reverse, aortic lipid lesions in apoE-/- mice
    Shui Pang Tam
    Department of Pathology and Molecular Medicine, Queen s University, and The Syl and Molly Apps Research Centre, Kingston General Hospital, Kingston, Ontario, Canada
    J Lipid Res 46:2091-101. 2005
    ..Such human peptides, or small molecule mimics of their structure, may prove to be potent antiatherogenic agents in humans...
  81. ncbi Sphingomyelinase D, a novel probe for cellular sphingomyelin: effects on cholesterol homeostasis in human skin fibroblasts
    Papasani V Subbaiah
    Department of Medicine, Rush Medical College, Chicago, IL 60612, USA
    J Lipid Res 44:1574-80. 2003
    ..Since ceramide phosphate does not appear to have such effects, we suggest that SMase D is a useful probe of membrane SM...
  82. ncbi Direct effect of F12511, a systemic inhibitor of Acyl-CoA cholesterol acyltransferase on bovine aortic endothelial cells
    José J Zamorano-León
    Cardiovascular Research Unit, Cardiovascular Institute, Hospital Clinico San Carlos, Madrid, Spain
    J Cardiovasc Pharmacol 48:128-34. 2006
    ..F12511 failed to modify the expression of the proinflammatory associated proteins PECAM and CD40L in the endothelium but protected eNOS expression in the endothelial cells exposed to inflammatory conditions...
  83. ncbi Catalysis of ACAT may be completed within the plane of the membrane: a working hypothesis
    T Y Chang
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755 3844, USA
    J Lipid Res 42:1933-8. 2001
    ..MTP then lipidates the growing apolipoprotein B (apoB) chain with CE and TG during the early stages of apoB lipoprotein assembly...
  84. ncbi Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii
    S Sonda
    Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, California 94143-0868, USA
    J Biol Chem 276:34434-40. 2001
    ..gondii. Moreover, we identified ACAT activity in T. gondii that can be modulated by pharmacological ACAT inhibitors with a consequent detrimental effect on parasite replication...
  85. pmc Biosynthesis of phytosterol esters: identification of a sterol o-acyltransferase in Arabidopsis
    Qilin Chen
    Plant Biotechnology Institute, National Research Council Canada, Saskatoon, Saskatchewan, Canada S7N 0W9
    Plant Physiol 145:974-84. 2007
    ....
  86. ncbi Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell-derived foam cells
    Tomohiro Miike
    Research Laboratories, Kyoto Pharmaceutical Industries, Ltd, Kyoto 604 8444, Japan
    Life Sci 82:79-84. 2008
    ....
  87. pmc Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages
    S Fazio
    Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, 315 Medical Research Building, Nashville, Tennessee 37232 6300, USA
    J Clin Invest 107:163-71. 2001
    ....
  88. ncbi Acyl-coenzyme A:cholesterol acyltransferase
    T Y Chang
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Annu Rev Biochem 66:613-38. 1997
    ..In addition, we present a working model linking the presumed allosteric property of ACAT with cholesterol trafficking into and out of the endoplasmic reticulum...
  89. ncbi Selectivity of pyripyropene derivatives in inhibition toward acyl-CoA:cholesterol acyltransferase 2 isozyme
    Taichi Ohshiro
    School of Pharmacy, Kitasato University, Tokyo, Japan
    J Antibiot (Tokyo) 61:503-8. 2008
    ..0 to 62 nM) than pyripyropene A (IC50: 70 nM). Among them, however, natural pyripyropene A showed the highest selectivity toward ACAT2 with a selectivity index (SI) of >1000, followed by PR-71 (SI, 667)...
  90. pmc TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2
    Camilla Pramfalk
    Division of Clinical Chemistry, Department of Laboratory Medicine, and Centre for Nutrition and Toxicology, Novum, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Lipid Res 55:709-17. 2014
    ..Depletion of Tgif1 in mice increased the hepatic Soat2 expression and resulted in higher hepatic lipid accumulation and plasma cholesterol levels. Tgif1 is a new player in human cholesterol metabolism...
  91. ncbi Liver gene expression in relation to hepatic steatosis and lipid secretion in two duck species
    F Herault
    INRA, UMR, Génétique Animale, Rennes, France
    Anim Genet 41:12-20. 2010
    ..These results should shed light on gene expression that might underlie susceptibility to hepatic steatosis in humans...
  92. ncbi The molecular target of rubimaillin in the inhibition of lipid droplet accumulation in macrophages
    Daisuke Matsuda
    Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
    Biol Pharm Bull 32:1317-20. 2009
    ..Furthermore, rubimaillin was found to inhibit the ACAT2 isozyme in ACAT2-expressing cells (IC(50): 22 microM). We concluded that rubimaillin is a dual inhibitor of ACAT1 and ACAT2, but is more selective for the ACAT2 isozyme...
  93. ncbi Lipids-induced apoptosis is aggravated by acyl-coenzyme A: cholesterol acyltransferase inhibitor
    Jian Ling Tao
    Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
    Chin Med Sci J 25:76-84. 2010
    ....
  94. ncbi Supplementation of Areca catechu L. extract alters triglyceride absorption and cholesterol metabolism in rats
    S J Byun
    Catholic Medical School, Taegu, Korea
    Ann Nutr Metab 45:279-84. 2001
    ..Hence, further studies are needed to elucidate the structure and chemical properties of the active compound in the water-soluble Areca extract that lowers cholesterol absorption...
  95. pmc Differential expression of genes and changes in glucose metabolism in the liver of liver-specific glucokinase gene knockout mice
    Rong Wang
    Department of Pharmacology, Peking University, Health Science Center, Beijing 100191, China
    Gene 516:248-54. 2013
    ..Changes in gluconeogenesis, delayed development of GCK and impaired hepatic glycogen synthesis in the liver potentially lead to the onset and progression of MODY2...
  96. ncbi Cyclodextrins differentially mobilize free and esterified cholesterol from primary human foam cell macrophages
    Sue M Liu
    Heart Research Institute, Camperdown, Sydney New South Wales, Australia
    J Lipid Res 44:1156-66. 2003
    ..It is concluded that differential depletion of plasma membrane cholesterol pools regulates cholesterol efflux and CE clearance in human macrophages...
  97. pmc Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism
    Ke Ma
    Section of Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine and Methodist Hospital, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:2748-53. 2003
    ..We conclude that EL is a major determinant of HDL concentration, structure, and metabolism in mice, and a major determinant of HDL concentration in humans...
  98. ncbi Role of cholesterol ester pathway in the control of cell cycle in human aortic smooth muscle cells
    Barbara Batetta
    Department of Biomedical Science and Biotechnology, University of Cagliari, Italy
    FASEB J 17:746-8. 2003
    ....
  99. ncbi Inhibitory effect of acyl-CoA:cholesterol acyltransferase inhibitor-low density lipoprotein complex on experimental atherosclerosis
    Yoshihiko Tauchi
    Department of Pharmaceutics, Hokkaido College of Pharmacy, 7 1 Katsuraoka cho, Otaru 047 0264, Japan
    Biol Pharm Bull 26:73-8. 2003
    ..Therefore, KV-LDL complex may be useful as a drug-carrier complex in antiatherosclerotic therapy...
  100. ncbi F 12511, a novel ACAT inhibitor, and atorvastatin regulate endogenous hypercholesterolemia in a synergistic manner in New Zealand rabbits fed a casein-enriched diet
    D Junquero
    Centre de Recherche Pierre Fabre, 17 Avenue Jean Moulin 81106 Cedex, Castres, France
    Atherosclerosis 155:131-42. 2001
    ..Thus, the combination of the ACAT inhibitor F 12511 with atorvastatin can represent a better approach than either agent alone to regulate lipoprotein metabolism in certain pathophysiological situations...
  101. ncbi Upregulation of acyl-CoA: cholesterol acyltransferase in chronic renal failure
    Kaihui Liang
    Division of Nephrology and Hypertension, Physiology and Biophysics, University of California, Irvine, California 92697, USA
    Am J Physiol Endocrinol Metab 283:E676-81. 2002
    ..Thus CRF results in significant upregulation of hepatic ACAT-2 (but not ACAT-1) expression and ACAT activity, which may, in part, contribute to the associated lipid disorders...

Research Grants13

  1. LIPID METABOLISM
    Herbert Kayden; Fiscal Year: 1980
    ..The method also permits the measurement of the exchange of tocopherol prophylactic role of tocopherol during cancer chemotherapy with adriamycin is under investigation. ..
  2. Attenuating sterol synthesis in WT and NPC mice brains
    Ta Yuan Chang; Fiscal Year: 2005
    ..Specific Aim 3: To examine the long-term effect of SSI CP-340868 at 2 different doses on life spans of normal and NPC1 mice. ..
  3. 2003 Kern Aspen Lipid Conference: Integrative Mechanisms
    Lawrence Rudel; Fiscal Year: 2003
    ..The timeliness of this meeting is viewed as a strength. ..
  4. Sterol Sensing and Transport in Model Eukaryote
    STEPHEN STURLEY; Fiscal Year: 2008
    ..We will test the ramifications of overexpression or knockdown of human ARVl in various tissue culture cell models. Lipid efflux to extracellular acceptors will be studied in detail. ..
  5. Mechanisms For PPARdelta Agonist-Induced Elevation of HDL in Non-Human Primates
    RYAN TEMEL; Fiscal Year: 2008
    ..abstract_text> ..
  6. 2006 Lipoprotein Metabolism Gordon Conference
    MARY SORCI THOMAS; Fiscal Year: 2006
    ....
  7. The role of CB2 receptors in oxLDL-induced apopotosis and atherogenesis
    Douglas Thewke; Fiscal Year: 2006
    ..They may also provide new pharmacologically exploitable targets for the development of novel pharmaceuticals for treatment of atherosclerosis. [unreadable] [unreadable] [unreadable]..
  8. Macrophage Death in Plaque Vulnerability
    Ira Tabas; Fiscal Year: 2005
    ..New insights in this area may suggest new therapeutic strategies to combat cardiovascular disease. ..
  9. INTERACTION OF ATHEROGENIC LIPOPROTEINS WITH MACROPHAGES
    IRA A TABAS; Fiscal Year: 2010
    ..abstract_text> ..
  10. Conference on Cellular Biology of Atherosclerosis
    Ira Tabas; Fiscal Year: 2005
    ....
  11. Regulation of stearoyl-CoA desaturases by oleate
    Douglas Thewke; Fiscal Year: 2004
    ..Ectotopic expression of SREBPs or other trans-acting factors will be used to determine their contribution to oleate regulation of SCD transcription. ..
  12. FORM CELL APO (A)/LP(A) RECEPTOR--CLONING AND FUNCTION
    Ira Tabas; Fiscal Year: 2002
    ..The studies in this proposal will lead to the molecular identification of a novel cholesterol-induced receptor on foam cells and should provide important insight into the role of foam cell-apo(a)/Lp(a) interactions in atherogenesis. ..