Genomes and Genes
phosphatidylcholine sterol o acyltransferase
Summary: An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma. EC 184.108.40.206.
Publications165 found, 100 shown here
- Lecithin cholesterol acyltransferaseA Jonas
Department of Biochemistry, University of Illinois, College of Medicine at Urbana Champaign, 506 South Mathews Avenue, 61801, Urbana, IL, USA
Biochim Biophys Acta 1529:245-56. 2000..Finally, overexpression of the human LCAT gene in mice and rabbits has been used to examine the physiologic role of LCAT in vivo and its protective effect against diet induced atherosclerosis...
- Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDLVassilis I Zannis
Molecular Genetics, Whitaker Cardiovascular Institute and Department of Biochemistry, Boston University School of Medicine, MA 02118, USA
J Mol Med (Berl) 84:276-94. 2006....
- Effects of increasing hydrophobicity on the physical-chemical and biological properties of a class A amphipathic helical peptideG Datta
The Atherosclerosis Research Unit and the Departments of Medicine and Biochemistry and Molecular Genetics, The University of Alabama at Birmingham Medical Center, Birmingham, AL 35294, USA
J Lipid Res 42:1096-104. 2001..These studies provide a rationale for the design of small apoA-I-mimetics with increased potency for atherosclerosis inhibition...
- Disparate effects of oxidation on plasma acyltransferase activities: inhibition of cholesterol esterification but stimulation of transesterification of oxidized phospholipidsP V Subbaiah
Department of Medicine, Rush Medical College, Chicago, IL 60612, USA
Biochim Biophys Acta 1301:115-26. 1996....
- Markedly accelerated catabolism of apolipoprotein A-II (ApoA-II) and high density lipoproteins containing ApoA-II in classic lecithin: cholesterol acyltransferase deficiency and fish-eye diseaseD J Rader
Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
J Clin Invest 93:321-30. 1994....
- Familial lecithin:cholesterol acyltransferase deficiency: molecular analysis of a compound heterozygote: LCAT (Arg147 --> Trp) and LCAT (Tyr171 --> Stop)M Guerin
Institut National de la Sante et de la Recherche Medicale INSERM, Unite 321, Pavillon Benjamin Delessert, Hopital de la Pitie, Paris, France
Atherosclerosis 131:85-95. 1997..In summary, we have identified an LCAT deficient patient corresponding to a compound heterozygote for the Arg147 --> Trp mutation and a new molecular defect involving a Tyr171 --> Stop mutation in the LCAT gene...
- Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferaseAlfonso Salvatore
Dipartimento delle Scienze Biologiche, Universita di Napoli Federico II, Via Mezzocannone 8, 80134 Napoli, Italy
Biochemistry 46:11158-68. 2007..Therefore haptoglobin, when circulating at enhanced levels with free Hb during the acute phase of inflammation, might protect ApoA-I structure and function against hydroxyl radicals...
- Assignment of the binding site for haptoglobin on apolipoprotein A-IMaria Stefania Spagnuolo
Dipartimento di Fisiologia Generale ed Ambientale, Universita di Napoli Federico II, Via Mezzocannone 8, 80134 Napoli, Italia
J Biol Chem 280:1193-8. 2005..Synthetic peptides, able to displace Hpt from ApoA-I without altering its property of binding hemoglobin, might be used for treatment of diseases associated with defective LCAT function...
- Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCATKyriakos E Kypreos
Molecular Genetics, Whitaker Cardiovascular Institute, Departments of Medicine and Biochemistry, Boston University School of Medicine, 715 Albany Street W509, Boston, MA 02118, USA
Biochem J 403:359-67. 2007..HDL particles generated by this pathway may account at least for some of the atheroprotective functions of apoE...
- Identification of a sequence of apolipoprotein A-I associated with the activation of Lecithin:Cholesterol acyltransferaseD Sviridov
Baker Medical Research Institute, Melbourne 8008 and the Department of Biochemistry, University of Melbourne, Parkville 3052, Victoria, Australia
J Biol Chem 275:19707-12. 2000....
- Inhibition of lecithin cholesterol acyltransferase by phosphatidylcholine hydroperoxidesA Davit-Spraul
Biochimie, Hopital Bicetre, Laboratoire de Biochimie, Le Kremlin Bicetre, France
FEBS Lett 447:106-10. 1999....
- A molecular defect causing fish eye disease: an amino acid exchange in lecithin-cholesterol acyltransferase (LCAT) leads to the selective loss of alpha-LCAT activityH Funke
Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat Munster, Federal Republic of Germany
Proc Natl Acad Sci U S A 88:4855-9. 1991..The homozygous presence of this mutation in two phenotypically homozygous members of an unrelated Dutch family with fish eye disease further supports this finding...
- LCAT modulates atherogenic plasma lipoproteins and the extent of atherosclerosis only in the presence of normal LDL receptors in transgenic rabbitsM E Brousseau
Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Arterioscler Thromb Vasc Biol 20:450-8. 2000..Moreover, LCAT's antiatherogenic effect requires only a single functional LDLr allele, identifying LCAT as an attractive gene therapy candidate for the majority of dyslipoproteinemic patients...
- Insight into the role of LCAT from mouse modelsDominic S Ng
Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
Rev Endocr Metab Disord 5:311-8. 2004
- Effect of up-regulating individual steps in the reverse cholesterol transport pathway on reverse cholesterol transport in normolipidemic miceK Alam
Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
J Biol Chem 276:15641-9. 2001..Thus, although rHDL stimulated cholesterol efflux from most tissues and increased net cholesterol movement from extrahepatic tissues to the liver, cholesterol flux through the entire RCT pathway was not increased...
- Abnormalities in uremic lipoprotein metabolism and its impact on cardiovascular diseaseT Quaschning
Department of Medicine, Division of Nephrology, , , Germany
Am J Kidney Dis 38:S14-9. 2001....
- The molecular basis of lecithin:cholesterol acyltransferase deficiency syndromes: a comprehensive study of molecular and biochemical findings in 13 unrelated Italian familiesLaura Calabresi
Center E Grossi Paoletti, Department of Pharmacological Sciences, University of Milano, 20133 Milan, Italy
Arterioscler Thromb Vasc Biol 25:1972-8. 2005..To better understand the role of lecithin:cholesterol acyltransferase (LCAT) in lipoprotein metabolism through the genetic and biochemical characterization of families carrying mutations in the LCAT gene...
- Reverse cholesterol transport and future pharmacological approaches to the treatment of atherosclerosisB R Krause
Department of Cardiovascular Therapeutics, Pfizer Global Research and Development, Ann Arbor, MI 48105, USA
Curr Opin Investig Drugs 2:375-81. 2001..Despite the complexities and uncertainties, drugs should be developed which impact all of the above steps, and short-term endpoints need to be defined for a cautious, systematic approach to clinical evaluation...
- Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potentialRichard G Lee
Arteriosclerosis Research Program, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Circ Res 95:998-1004. 2004..Overall, the data suggest that ACAT2-derived CE is the predominant atherogenic lipid in blood, and that an important goal for prevention of atherosclerosis is to limit ACAT2-derived CE accumulation in lipoproteins...
- Effects of HMG-CoA reductase inhibition on hepatic expression of key cholesterol-regulatory enzymes and receptors in nephrotic syndromeNosratola D Vaziri
Division of Nephrology and Hypertension, University of California, Irvine, Orange, Calif 92868, USA
Am J Nephrol 24:606-13. 2004..This study was carried out to discern the effect of inhibition of HMG-CoA reductase on expression of the key enzymes and receptors involved in cholesterol metabolism in the liver...
- Molecular mechanism of reverse cholesterol transport: reaction of pre-beta-migrating high-density lipoprotein with plasma lecithin/cholesterol acyltransferaseYasushi Nakamura
Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
Biochemistry 43:14811-20. 2004..The cholesteryl ester produced in pre-beta(1)-HDL in turn became the preferred substrate of CETP. Selective LCAT-mediated reactivity with pre-beta(1)-HDL represents a novel mechanism increasing the efficiency of RCT...
- Differential additive effects of endothelial lipase and scavenger receptor-class B type I on high-density lipoprotein metabolism in knockout mouse modelsKe Ma
Section of Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, and St Luke s Episcopal Hospital, Houston, Tex 77030, USA
Arterioscler Thromb Vasc Biol 25:149-54. 2005..Scavenger receptor-class B type I (SR-BI) is an HDL receptor that mediates the selective uptake of cholesteryl ester. This study investigates the role of EL and SR-BI in the regulation of HDL metabolism in gene knockout mouse models...
- Abnormal lipid metabolism in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemiaKazuhiko Namekata
National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawahigashi 4 1 1, Kodaira, Tokyo 187 8551, Japan
J Biol Chem 279:52961-9. 2004..Moreover, serum cholesterol/triglyceride distribution in lipoprotein fractions was altered in CBS(-/-) mice. These results suggest that hepatic steatosis in CBS(-/-) mice is caused by or associated with abnormal lipid metabolism...
- Increased low-density lipoprotein oxidation and impaired high-density lipoprotein antioxidant defense are associated with increased macrophage homing and atherosclerosis in dyslipidemic obese mice: LCAT gene transfer decreases atherosclerosisAnn Mertens
Cardiovascular Research Unit at the Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Campus Gasthuisberg, O and N, Herestraat 49, B 3000 Leuven, Belgium
Circulation 107:1640-6. 2003..We investigated the association between oxidation of apolipoprotein B-containing lipoproteins, high-density lipoprotein (HDL) antioxidant defense, and atherosclerosis in these mice...
- Dietary fats differentially modulate the expression of lecithin:cholesterol acyltransferase, apoprotein-A1 and scavenger receptor b1 in ratsWael Hatahet
Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202, USA
J Nutr 133:689-94. 2003..Overall, these results suggest that triolein may promote RCT and thus retard the development of atherosclerosis...
- LCAT-dependent conversion of prebeta1-HDL into alpha-migrating HDL is severely delayed in hemodialysis patientsTakashi Miida
Division of Clinical Preventive Medicine, Department of Community Preventive Medicine, Niigata University, Graduate School of Medical and Dental Sciences, Japan
J Am Soc Nephrol 14:732-8. 2003..001). In conclusion, the LCAT-dependent conversion of prebeta1-HDL to alpha-migrating HDL is severely delayed in hemodialysis patients. The impaired catabolism of prebeta1-HDL may accelerate atherosclerosis in hemodialysis patients...
- Enhancement of scavenger receptor class B type I-mediated selective cholesteryl ester uptake from apoA-I(-/-) high density lipoprotein (HDL) by apolipoprotein A-I requires HDL reorganization by lecithin cholesterol acyltransferaseRyan E Temel
Department of Pharmacological Sciences, University Medical Center, State University of New York, Stony Brook, New York 11794, USA
J Biol Chem 278:4792-9. 2003..These data suggest that the conformation of apoA-I at the HDL surface is important for the efficient transfer of CE to the cell...
- Effect of acute Chlamydia pneumoniae infection on lipoprotein metabolism in NIH/S miceT Tiirola
National Public Health Institute, Department of Molecular Medicine, Biomedicum, Helsinki, Finland
Scand J Clin Lab Invest 62:477-84. 2002..i. The data indicate that acute C. pneumoniae infection, although clinically almost asymptomatic, causes small, transient changes in serum total lipids and some key proteins involved in lipoprotein metabolism in mice...
- Hypertriglyceridemia in lecithin-cholesterol acyltransferase-deficient mice is associated with hepatic overproduction of triglycerides, increased lipogenesis, and improved glucose toleranceDominic S Ng
Department of Medicine, St Michael s Hospital, Toronto, Ontario M5B 1A6, Canada
J Biol Chem 279:7636-42. 2004..014). Both the HTG and the improved fasting glucose phenotype seen in the dko mice are at least in part attributable to an up-regulation of the hepatic srebp-1c gene...
- Genetic and environmental determinants of plasma high density lipoprotein cholesterol and apolipoprotein AI concentrations in healthy middle-aged menP J Talmud
Division of Cardiovascular Genetics, Department of Medicine, British Heart Foundation Loboratories, Rayne Building, Royal Free and University College Medical School, 5 University St, London WCIE 6JJ, UK
Ann Hum Genet 66:111-24. 2002....
- HDL: the metabolism, function, and therapeutic importanceMinghan Wang
Department of Cardiovascular and Metabolic Diseases, Pharmacia Corporation, 800 North Lindbergh Boulevard, St Louis, Missouri 63167, USA
Chem Rev 104:119-37. 2004
- Physical fitness and reverse cholesterol transportBeata Olchawa
Baker Heart Research Institute, Wynn Domain, Melbourne, Victoria, Australia
Arterioscler Thromb Vasc Biol 24:1087-91. 2004..The most consistent effect of exercise on lipoprotein metabolism is an increase in high-density lipoprotein (HDL)...
- Postprandial chylomicrons: potent vehicles for transporting cholesterol from endogenous LDL+HDL and cell membranes to the liver via LCAT and CETPByung Hong Chung
Atherosclerosis Research Unit, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Lipid Res 45:1242-55. 2004....
- Remodeling of HDL remnants generated by scavenger receptor class B type INancy R Webb
Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY, USA
J Lipid Res 45:1666-73. 2004..We conclude that HDL remnants, generated by SR-BI, are converted to larger particles by rapidly reassociating with existing HDL particles in an enzyme-independent manner...
- Effects of intravenous apolipoprotein A-I/phosphatidylcholine discs on LCAT, PLTP, and CETP in plasma and peripheral lymph in humansTakeshi Kujiraoka
Department of Advanced Medical Technology and Development, BML, Inc, 1361 1 Matoba, Kawagoe, Saitama 350 1101, Japan
Arterioscler Thromb Vasc Biol 23:1653-9. 2003....
- Increased plasma HDL cholesterol levels and biliary cholesterol excretion in hamster by LCAT overexpressionAi Hong Zhang
Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiology, Ministry of Education, Peking University, 38 Xue Yuan Road, Beijing 100083, PR China
FEBS Lett 570:25-9. 2004..This study suggests that overexpression of hLCAT in hamsters facilitated reverse cholesterol transport. Similar metabolic changes in humans might modify atherogenic risk...
- Effect of long-term hemodialysis on plasma lecithin: cholesterol acyltransferase activity and the amounts and compositions of HDL2 and HDL3 in hemodialysis-treated patients with chronic renal failure: a 9-year longitudinal studyKhedidja Mekki
Laboratoire de Nutrition Clinique et Métabolique, Departement de Biologie, Faculte des Sciences, Université d Oran Es Senia, Algerie
Med Sci Monit 10:CR439-46. 2004..Atherosclerosis was correlated with hemodialysis duration (HD) in chronic renal failure (CRF) patients. Dyslipidemias were identified as atherogenic risk factors...
- Evaluation of phospholipid transfer protein and cholesteryl ester transfer protein as contributors to the generation of pre beta-high-density lipoproteinsJ Lie
Department of Biochemistry, Cardiovascular Research Institute COEUR, Erasmus University Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
Biochem J 360:379-85. 2001..These data support the hypothesis of a role for PLTP in the initial stage of reverse cholesterol transport...
- Recombinant proapoA-I(Lys107del) shows impaired lipid binding associated with reduced binding to plasma high density lipoproteinW Huang
Department of Internal Medicine, Fukuoka University, School of Medicine, 45-1, 7-chome Nanakuma, Jonan-ku, 814-80, Fukuoka, Japan
Atherosclerosis 159:85-91. 2001....
- Reverse cholesterol transport: high-density lipoprotein's magnificent milePeter P Toth
Sterling Rock Falls Clinic, 101 East Miller Road, Sterling, IL 61081, USA
Curr Atheroscler Rep 5:386-93. 2003
- HDLs in apoA-I transgenic Abca1 knockout mice are remodeled normally in plasma but are hypercatabolized by the kidneyJi Young Lee
Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Lipid Res 46:2233-45. 2005....
- Functional LCAT deficiency in human apolipoprotein A-I transgenic, SR-BI knockout miceJi Young Lee
Department of Pathology Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Lipid Res 48:1052-61. 2007..We conclude that the decreased EC/TC ratio in the plasma of hA-ITg SR-BI-/- mice is attributed to a reduction in LCAT reactivity with SM-enriched HDL particles...
- LCAT can rescue the abnormal phenotype produced by the natural ApoA-I mutations (Leu141Arg)Pisa and (Leu159Arg)FINGeorgios Koukos
Molecular Genetics, Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Biochemistry 46:10713-21. 2007..Both defects can be corrected by treatment with LCAT...
- Role of plasma and liver cholesterol- and lipoprotein-metabolism determinants in LpX formation in the mouseIgnacio Bravo
Departamento de Gastroenterologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Marcoleta 367, Casilla 114 D, Santiago, Chile, and Brigham and Women s Hospital, Boston, MA 02115, USA
Biochim Biophys Acta 1770:979-88. 2007....
- Effects of apoA-V on HDL and VLDL metabolism in APOC3 transgenic miceShen Qu
Rangos Research Center, Children s Hospital of Pittsburgh, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Lipid Res 48:1476-87. 2007..These data suggest that in addition to its TG-lowering effect, apoA-V plays a significant role in modulating HDL maturation and cholesterol metabolism...
- Effects of probucol on plasma lipids, lipoproteins and parameters of high density lipoprotein metabolismJ R Wetterau
Department of Pharmacology and Cell Biophysics, University of Cincinnati
Horm Metab Res 24:289-96. 1992..We propose that the increase in lipid transfer activity may in part explain the changes in HDL concentration and size, as well as the previously reported effect probucol has on reducing atherosclerosis in animal models...
- Naturally occurring and bioengineered apoA-I mutations that inhibit the conversion of discoidal to spherical HDL: the abnormal HDL phenotypes can be corrected by treatment with LCATGeorgios Koukos
Molecular Genetics, Departmental of Medicine and Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
Biochem J 406:167-74. 2007..The correction of the aberrant HDL phenotypes by treatment with LCAT suggests a potential therapeutic intervention for HDL abnormalities that result from specific mutations in apoA-I...
- SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDLLaurent Yvan-Charvet
Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY, USA
J Lipid Res 49:107-14. 2008..Previous findings of increased atherosclerosis in mice transplanted with SR-BI(-/-) bone marrow probably cannot be explained by a defect in macrophage cholesterol efflux...
- A cholesteryl ester transfer complex in human plasmaP E Fielding
Proc Natl Acad Sci U S A 77:3327-30. 1980..The apparent stoichiometry of the complex with LCAT (LCAT:apo A-1:apo D) was 1.0:0.9:1.8; that of the complex containing apo A-1, apo A-2, and apo D was 3.9:2.2:1.0...
- A unique genetic and biochemical presentation of fish-eye diseaseJ A Kuivenhoven
Department of Haemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Academic Medical Centre, University of Amsterdam, The Netherlands
J Clin Invest 96:2783-91. 1995..The impact of this mutation on HDL levels and HDL subclass distribution may be related to the premature coronary artery disease observed in the male probands...
- Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out miceChristina Christoffersen
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
J Biol Chem 283:1839-47. 2008..The effect of apoM on atherosclerosis may be facilitated by enzymatic modulation of plasma HDL particles, increased cholesterol efflux from foam cells, and an antioxidative effect of apoM-containing HDL...
- Intraretinal lipid transport is dependent on high density lipoprotein-like particles and class B scavenger receptorsNomingerel Tserentsoodol
Laboratory of Retinal Cell and Molecular Biology, Section on Mechanisms of Retinal Diseases, National Eye Institute, NIH, Bethesda, MD 20892, USA
Mol Vis 12:1319-33. 2006..In order to understand how these lipids are transported within the retina, expression and localization of the main proteins known to be involved in systemic lipid transport was determined...
- Involvement of serum apolipoprotein AI and B100 and lecithin cholesterol acyl transferase in alcoholic cirrhoticsAbraham Lemberg
Portal Hypertension Laboratory, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
Ann Hepatol 6:227-32. 2007..Moreover oxidative stress participate possible as a major mechanism in liver damage...
- Coordinated alteration of hepatic gene expression in fatty acid and triglyceride synthesis in LCAT-null mice is associated with altered PUFA metabolismHui Song
Department of Medicine, St Michael s Hospital, Toronto, ON M5B 1A6, Canada
Am J Physiol Endocrinol Metab 290:E17-E25. 2006..Some of the phenotypes are not readily explained by known mechanisms and may represent novel regulatory pathways...
- Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levelsX C Jiang
Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
J Clin Invest 103:907-14. 1999..Vesicular lipoproteins accumulating in PLTP-/- mice on a high-fat diet could influence the development of atherosclerosis...
- Effects of hepatic expression of the high-density lipoprotein receptor SR-BI on lipoprotein metabolism and female fertilityAyce Yesilaltay
Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139, USA
Endocrinology 147:1577-88. 2006....
- Common variants of multiple genes that control reverse cholesterol transport together explain only a minor part of the variation of HDL cholesterol levelsS M Boekholdt
Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
Clin Genet 69:263-70. 2006..Multiple environmental and genetic influences on HDL-C plasma levels still have to be elucidated...
- Cloning and in vitro expression of rat lecithin:cholesterol acyltransferaseJ Wang
Department of Comparative Medicine, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, NC 27157, USA
Biochim Biophys Acta 1346:207-11. 1997....
- HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathwayFumihiko Matsuura
Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York, USA
J Clin Invest 116:1435-42. 2006..Thus, CETP-D HDL has enhanced ability to promote cholesterol efflux from foam cells in an ABCG1-dependent pathway due to an increased content of LCAT and apoE...
- Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentrationT M Forte
Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94729, USA
J Lipid Res 40:1276-83. 1999..2 nm particles. We conclude that the concomitant reduction in HDL and apoA-I concentrations and PON and PAF-AH activities is best explained by rapid clearance of the small HDL particles found in LCAT deficiency...
- Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genesN Fournier
Laboratoire de biochimie appliquée, Faculte des Sciences Pharmaceutiques et Biologiques, Chatenay Malabry, France
Atherosclerosis 147:227-35. 1999....
- Influence of genetic polymorphisms on responsiveness to dietary fat and cholesterolS Q Ye
Lipid Research Atherosclerosis Division, Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Am J Clin Nutr 72:1275S-1284S. 2000....
- LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteinsVeronica Hirsch-Reinshagen
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
J Lipid Res 50:885-93. 2009..These data show that brain LCAT esterifies cholesterol on glial-derived apoE-lipoproteins, and influences CSF apoE and apoA-I levels...
- Adenoviral expression of human lecithin-cholesterol acyltransferase in nonhuman primates leads to an antiatherogenic lipoprotein phenotype by increasing high-density lipoprotein and lowering low-density lipoproteinMarcelo J A Amar
Lipoprotein Metabolism Section, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Metabolism 58:568-75. 2009..05). In summary, overexpression of LCAT in nonhuman primates leads to an antiatherogenic lipoprotein profile by increasing HDL cholesterol and lowering ApoB, thus making LCAT a potential drug target for reducing atherosclerosis...
- The ability of plasma to stimulate fibroblast cholesterol efflux is associated with the -629C-->A cholesteryl ester transfer protein promoter polymorphism: role of lecithin: cholesterol acyltransferase activityS E Borggreve
Department of Endocrinology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
Biochim Biophys Acta 1781:10-5. 2008....
- Negative charge at amino acid 149 is the molecular determinant for substrate specificity of lecithin: cholesterol acyltransferase for phosphatidylcholine containing 20-carbon sn-2 fatty acyl chainsYue Zhao
Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
Biochemistry 42:13941-9. 2003..We conclude that the negative charge at amino acid 149 of LCAT is a critical determinant for the specificity of the enzyme for PC containing 18- vs 20-carbon sn-2 fatty acyl chains...
- Plasma levels of lecithin:cholesterol acyltransferase and risk of future coronary artery disease in apparently healthy men and women: a prospective case-control analysis nested in the EPIC-Norfolk population studyA G Holleboom
Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
J Lipid Res 51:416-21. 2010..45, CI: 0.94-2.22, P for linearity = 0.036). In contrast to our studies in carriers of LCAT mutations, the current data show that low LCAT plasma levels are not associated with increased atherosclerosis in the general population...
- Abnormal function of high-density lipoprotein is associated with poor disease control and an altered protein cargo in rheumatoid arthritisChristina Charles-Schoeman
David Geffen School of Medicine at University of California, Los Angeles, CA 90095 1670, USA
Arthritis Rheum 60:2870-9. 2009....
- Beneficial effects of fish liver preparations of sea bass (Lates calcarifer) versus gemfibrozil in high fat diet-induced lipid-intolerant ratsF Rizvi
Aquatic Environmental Laboratory, Central Institute of Fisheries Education, Versova Mumbai 400061, India
J Med Food 6:123-8. 2003..These data suggest that FLPs and gemfibrozil not only lower lipid intolerance but also reduce diabetic-dyslipidemic complications by activating peroxisome proliferator-activated receptors (PPAR)...
- Evaluation of the antioxidant response in the plasma of healthy or hypertensive subjects after short-term exerciseL Santangelo
Dipartimento di Scienze Cardio Toraciche e Respiratorie, Seconda Università di Napoli Piazza L Miraglia, Napoli, Italy
J Hum Hypertens 17:791-8. 2003..The results demonstrate that exercise is associated with enhanced protein nitrosation, and suggest that the ascorbate or urate levels increase to limit oxidative damage...
- Alcohol-mediated enhancement of postprandial lipemia: a contributing factor to an increase in plasma HDL and a decrease in risk of cardiovascular diseaseByung Hong Chung
Department of Medicine, School of Medicine, University of Alabama, Birmingham, 35294, USA
Am J Clin Nutr 78:391-9. 2003..Moderate alcohol consumption increases plasma HDL and lowers cardiovascular disease risk while transiently enhancing postprandial lipemia...
- Antioxidative activity of HDL particle subspecies is impaired in hyperalphalipoproteinemia: relevance of enzymatic and physicochemical propertiesAnatol Kontush
Dyslipoproteinemia and Atherosclerosis Research Unit U 551, National Institute for Health and Medical Research, Hopital de la Pitie, Paris, France
Arterioscler Thromb Vasc Biol 24:526-33. 2004..The impact of such modification on antioxidative activities of HDL subfractions is indeterminate...
- Fractal binding and dissociation kinetics of heart-related compounds on biosensor surfacesAtul M Doke
Chemical Engineering Department, University of Mississippi, University, Mississippi 38677 184, USA
J Recept Signal Transduct Res 26:337-57. 2006..The analysis presented provided physical insights into these analyte-receptor reactions occurring on different biosensor surfaces...
- Comparison of mechanism and functional effects of magnesium and statin pharmaceuticalsAndrea Rosanoff
Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA
J Am Coll Nutr 23:501S-505S. 2004..Mg at optimal cellular concentration is well accepted as a natural calcium channel blocker. More recent work shows that Mg also acts as a statin...
- Protective effect of rutin on lipids, lipoproteins, lipid metabolizing enzymes and glycoproteins in streptozotocin-induced diabetic ratsP Stanely Mainzen Prince
Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar 608 002, Tamilnadu, India
J Pharm Pharmacol 58:1373-83. 2006..05) changes in any of the parameters studied. In conclusion, the beneficial effect of rutin on lipids, lipoproteins, lipid metabolizing enzymes and glycoproteins could be due to its antioxidant property...
- Substitutions of glutamate 110 and 111 in the middle helix 4 of human apolipoprotein A-I (apoA-I) by alanine affect the structure and in vitro functions of apoA-I and induce severe hypertriglyceridemia in apoA-I-deficient miceAngeliki Chroni
Molecular Genetics, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Massachusetts, USA
Biochemistry 43:10442-57. 2004..The findings indicate that subtle structural alterations in apoA-I may alter the stability and functions of apoA-I and high-density lipoprotein (HDL) and may cause hypertriglyceridemia...
- Selective uptake of high density lipoproteins cholesteryl ester in the dog, a species lacking in cholesteryl ester transfer protein activity; An in vivo approach using stable isotopesKhadija Ouguerram
Centre de Recherche en Nutrition Humaine, INSERM U539, CHU Nantes, 1 Place Alexis Ricordeau, 44093 Nantes 01, France
Comp Biochem Physiol B Biochem Mol Biol 138:339-45. 2004..This study shows that among species used to analyze cholesterol metabolism, the dog appears to be the animal in whom HDL-CE selective uptake represents the largest part of HDL-CE turnover...
- [Measurement of LCAT]Shin Ichiro Miura
Department of Cardiology, Fukuoka University Hospital
Nihon Rinsho 65:199-201. 2007
- Cholesterol metabolism in rat is affected by protocatechuic acidAkiko Tamura
Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
J Nutr Sci Vitaminol (Tokyo) 50:13-8. 2004..The results of this study suggest the possibility that the increase in the hepatic LDL receptor, apo E, LCAT and HTGL guessed by these mRNAs increase in the protocatechuic acid group lowers the serum total cholesterol level...
- Changes in serum lipoprotein lipids and their fatty acid compositions and lipid peroxidation in growing rats fed soybean protein versus casein with or without cholesterolSihem Madani
Unité de Nutrition Cellulaire et Métabolique, Faculte des Sciences Gabriel, Dijon, France
Nutrition 20:554-63. 2004..1% cholesterol on plasma lipoprotein lipid amounts and their fatty acid compositions, lecithin:cholesterol acyl-transferase activity, and lipid peroxidation...
- Alterations in lipoprotein homeostasis during human experimental endotoxemia and clinical sepsisJohannes H M Levels
Department of Experimental Vascular Medicine, University of Amsterdam, Amsterdam, The Netherlands
Biochim Biophys Acta 1771:1429-38. 2007..This may be explained, at least in part, by the fact that PLTP as a positive acute phase protein, can accelerate the alterations in (phospho)lipid homeostasis thereby playing a role in the attenuation of the acute phase response...
- Increased plasma lipid-poor apolipoprotein A-I in patients with coronary artery diseaseMakiko Suzuki
Department of Informative Clinical Medicine, Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
Clin Chem 51:132-7. 2005..In this study, we separated plasma lipid-poor apolipoprotein A-I (apo A-I) by high-performance size-exclusion chromatography...
- Lecithin:cholesterol acyltransferase reduces the adverse effects of oxidized low-density lipoprotein while incurring damage itselfZ H Howlader
Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
Biosci Biotechnol Biochem 65:2496-503. 2001..This ability of LCAT to repair oxLDL was dose-dependent. But there was no change in its REM values or fluorescence intensity...
- Effect of 20 days' bed rest on the reverse cholesterol transport system in healthy young subjectsR Yanagibori
Aichi Prefectural College of Nursing and Health, Nagoya, Japan
J Intern Med 243:307-12. 1998..To study the effects of 20 days of bed rest on HDL cholesterol, lipoprotein lipase, hepatic triglyceride lipase, cholesterol ester transfer protein and lecithin-cholesterol acyltransferase...
- Effect of probucol on serum lipoprotein and apoprotein profiles in renal transplant patientsM Okubo
Department of Medicine, Sano Kohsei Hospital, Tochigi, Japan
Am J Kidney Dis 31:356-9. 1998..These data suggest that although probucol causes a decrease in HDL-CHL, it may act anti-atherogenically by modulating HDL metabolism and stimulating reverse transfer of CHL from peripheral tissue...
- The isolation and characterisation of cDNA and genomic clones for human lecithin: cholesterol acyltransferaseF Tata
Department of Biochemistry and Molecular Genetics, St Mary s Hospital Medical School, University of London, U K
Biochim Biophys Acta 910:142-8. 1987..The cDNA probe was used to isolate LCAT genomic recombinants from a human genomic library. Southern blotting data, and restriction site mapping, suggest that there is a single human LCAT structural gene between 4.3 and 5.5 kb in size...
- Chicken lecithin-cholesterol acyltransferase. Molecular characterization reveals unusual structure and expression patternE Hengstschläger-Ottnad
Department of Molecular Genetics, University and Biocenter Vienna, Austria
J Biol Chem 270:26139-45. 1995....
- Three arginine residues in apolipoprotein A-I are critical for activation of lecithin:cholesterol acyltransferaseS Roosbeek
Laboratory for Lipoprotein Chemistry, Department of Biochemistry, Ghent University, B-9000 Ghent, Belgium
J Lipid Res 42:31-40. 2001..Breyne, I. De Beun, H. Patel, J. Vandekerckhove, C. Shoulders, M. Rosseneu, and F. Peelman. Three arginine residues in apolipoportein A-I are critical for activation of lecithin:cholesterol acyltransferase J. Lipid Res. 2001. 42: 31;-40...
- Lipid-lowering and antioxidative activities of 3,4-di(OH)-cinnamate and 3,4-di(OH)-hydrocinnamate in cholesterol-fed ratsJ S Lee
Department of Food Science and Nutrition, Kyungpook National University, 1370 Sank-Yuk Dong Puk-Ku, Taegu 702-701, South Korea
Clin Chim Acta 314:221-9. 2001..Furthermore, these results also suggest that 3,4-di(OH)-cinnamate is more effective than 3,4-di(OH)-hydrocinnamate in its lipid-lowering action...
- Effects of long-term, low-fat diet on plasma apo E in familial LCAT deficiencyS Homma
Department of Internal Medicine, Jichi Medical School, Tochigi, Japan
Nihon Jinzo Gakkai Shi 35:999-1006. 1993..A low-fat diet may be effective in correcting lipid abnormalities. Moreover, plasma apo E may be a good indicator of the efficacy of diet therapy...
- The role of plasma phospholipid transfer protein (PLTP) in HDL remodeling in acute-phase patientsP J Pussinen
National Public Health Institute, Department of Molecular Medicine, Biomedicum Helsinki, Helsinki, Finland
Biochim Biophys Acta 1533:153-63. 2001..We suggest that the decrease of HDL during the acute phase is caused by reduced LCAT and increased PLTP activities both increasing the plasma levels of lipid-poor apoA-I particles...
- Effect of acylglyceride content on the structure and function of reconstituted high density lipoprotein particlesS Braschi
, , Creteil, France
J Lipid Res 42:79-87. 2001..Braschi, S., C. R. Coffill, T. A-M. Neville, D. M. Hutt, and D. L. Sparks. Effect of acylglyceride content on the structure and function of reconstituted high density lipoprotein particles. J. Lipid Res. 2001. 42: 79;-87...
- Lecithin:cholesterol acyltransferase deficiency: identification of a causative gene mutation and a co-inherited protein polymorphismJ S Hill
University Hospital Lipid Research Group, Department of Pathology, University of British Columbia, Vancouver, Canada
Biochim Biophys Acta 1181:321-3. 1993..We demonstrate that the Ala-93-->Thr mutation is responsible for the biochemical defect while the Arg-158-->Cys mutation is a co-inherited natural polymorphism of LCAT which results in normal enzyme function...
- Fish eye syndrome: a molecular defect in the lecithin-cholesterol acyltransferase (LCAT) gene associated with normal alpha-LCAT-specific activity. Implications for classification and prognosisH G Klein
Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
J Clin Invest 92:479-85. 1993....
- Recombinant lecithin:cholesterol acyltransferase containing a Thr123-->Ile mutation esterifies cholesterol in low density lipoprotein but not in high density lipoproteinK O
Department of Pathology, University of British Columbia, Vancouver, Canada
J Lipid Res 34:81-8. 1993....
- The improvement effect of L-Lys as a chemical chaperone on STZ-induced diabetic rats, protein structure and functionA Jafarnejad
Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Diabetes Metab Res Rev 24:64-73. 2008..In addition, the effect of L-Lys, as a chemical chaperone, was considered on protein folding and activity...
- Lecithin: cholesterol acyltransferase activity in familial hypercholesterolemia treated with simvastatin and simvastatin plus low-dose colestipolJ P Desager
Laboratoire de Pharmacotherapie, Universite Catholique de Louvain, Brussels, Belgium
J Clin Pharmacol 31:537-42. 1991..This original design allowed to define the most appropriate individual cholesterol-lowering drug dosage in FH patients...
- Serum paraoxonase activity decreases in rheumatoid arthritisNoriyasu Tanimoto
Second Department of Internal Medicine, Kochi Medical School, Kohasu Okoh Cho, Nankoku, Kochi, 783 8505, Japan
Life Sci 72:2877-85. 2003..To estimate the alterations of paraoxonase 1 (PON1) and high-density lipoprotein (HDL) in rheumatoid arthritis (RA)...
- The seeds from Plantago ovata lower plasma lipids by altering hepatic and bile acid metabolism in guinea pigsAna Lourdes Romero
Department of Food Science, University of Sonora, Hermosillo, Sonora State, Mexico
J Nutr 132:1194-8. 2002..02). Fecal bile acids were 3 times higher in the PO groups than in the control group. These results suggest that PO exerts its hypolipidemic effect by affecting bile acid absorption and altering hepatic cholesterol metabolism...
- Formation of spherical, reconstituted high density lipoproteins containing both apolipoproteins A-I and A-II is mediated by lecithin:cholesterol acyltransferaseM A Clay
The University of Adelaide, Department of Medicine, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia
J Biol Chem 275:9019-25. 2000..The results presented are consistent with LCAT promoting fusion of the A-I rHDL and A-II rHDL to form spherical A-I/A-II rHDL. We suggest that this process may be an important source of A-I/A-II HDL in human plasma...
- Disruption of the murine lecithin:cholesterol acyltransferase gene causes impairment of adrenal lipid delivery and up-regulation of scavenger receptor class B type ID S Ng
Human Genome Center, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
J Biol Chem 272:15777-81. 1997....
- ROLE OF SPHINGOMYELIN IN LIPOPROTEIN METABOLISMPapasani Subbaiah; Fiscal Year: 2008..These studies will provide novel insights into the physiological role of this important phospholipid, and could possibly open up novel therapeutic targets against inflammation and atherosclerosis. ..
- LCAT AND PATHOPHYSIOLOGY OF PHOSPHOLIPID SPECIESPapasani Subbaiah; Fiscal Year: 2002..These studies should provide novel insights into the physiological importance of LCAT beyond its role in cholesterol esterification. ..
- Functions of apoE in cholesterol and triglyceride homeostasisVassilis I Zannis; Fiscal Year: 2010..Gene transfer in single or double knockout mice for apoA-l, apoE, SR-BI and biochemical analyses will be employed in these studies. ..
- HIGH DENSITY LIPOPROTEIN SUBSPECIES AND CORONARY DISEASEBela Asztalos; Fiscal Year: 2003..The investigators state that these studies should provide better understanding about the diagnosis and treatment of HDL deficiency for the prevention of CHD. ..
- APOLIPOPROTEIN VARIATION AND HUMAN DISEASEVassilis Zannis; Fiscal Year: 2003..Thus the information obtained from this project may provide rational approaches towards correcting low plasma HDL levels and reducing hypertriglyceridemia in humans. ..
- EFFECT OF DIETARY LIPIDS ON THE FUNCTION OF CHYLOMICRONSByung Hong Chung; Fiscal Year: 2002..abstract_text> ..
- Novel Pathways of Cellular Cholesterol EffluxAlan Tall; Fiscal Year: 2005....
- Pharmacogenetics of the Statin ResponseERNST SCHAEFER; Fiscal Year: 2006..These results can be used to formulate guidelines for identifying elderly subjects for statin treatment to prevent future CHD. ..
- 2006 Lipoprotein Metabolism Gordon ConferenceMARY SORCI THOMAS; Fiscal Year: 2006....
- ABCA1 agonist peptides for therapeutic useJOHN BIELICKI; Fiscal Year: 2008..The research is likely to have a high impact on public health, since the therapeutics will be amenable to the widespread treatment of atherosclerosis. [unreadable] [unreadable] [unreadable] [unreadable]..
- ABCA7: Cellular Functions and Role in AtherosclerosisAlan Tall; Fiscal Year: 2009..Overall, this proposal will elucidate the in vivo functions of a novel ABC transporter and its role in macrophage clearance of apoptotic cells, inflammation and atherogenesis. ..
- HIGH DENSITY LIPOROTEIN STRUCTURE-FUNCTION CORRELATIONSAna Jonas; Fiscal Year: 2001..These studies are expected to localize the "hinge" region of apoA-I and to clarify its mechanism in several important functions of apoA-I. ..
- MOLECULAR BASIS OF HIGH DENSITY LIPOPROTEIN DEFICIENCYERNST SCHAEFER; Fiscal Year: 2009..The results of this work will provide important insight into the contribution of allelic variation in the pathways of HDL metabolism, inflammation, and insulin resistance to the complex phenotype of low HDL-C. ..
- Macrophage Foam Cells, Cathepsins and Cholesterol EffluxALAN RICHARD TALL; Fiscal Year: 2010..These mechanistic insights may suggest new treatments for vulnerable human plaques such as LXR activators, CatK inhibitors or inhibitors of RANK signaling. ..
- ApoA-I Helical Domains and Cardiovascular AgingJOHN BIELICKI; Fiscal Year: 2005..These studies are relevant for devising novel strategies to combat cardiovascular aging. ..
- SCAVENGER RECEPTOR B1 AND HDL METABOLISMAlan Tall; Fiscal Year: 2005..The work will provide crucial insights into the cellular mechanisms underlying the final step of reverse cholesterol transport. The findings will be relevant to the relationship between HDL, atherosclerosis and gallstone formation. ..
- CELLULAR BASIS OF ANTIATHEROGENESIS BY APOLIPOPROTEIN EDaniel Rader; Fiscal Year: 2001..These studies will provide greater understanding of the role of the local inflammatory response in atherosclerosis and its regulation by apoE. ..
- MOLECULAR MECHANISMS OF ASSEMBLY OF APOPB LIPOPROTEINSJERE SEGREST; Fiscal Year: 2001..The results of specific aims 1 and 2 will determine the specific sites and types of mutations selected. ..
- GENETIC DETERMINANTS OF PLASMA LIPOPROTEINSJonathan Cohen; Fiscal Year: 2002..These studies will help to determine the role of variation in hepatic lipase activity in determining plasma HDL concentrations, and LDL size distribution, two important risk factors for coronary artery disease. ..
- DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISKERNST SCHAEFER; Fiscal Year: 2003..abstract_text> ..
- Arg199: key player in electron transfer in NOS enzymeValentin Gogonea; Fiscal Year: 2004..Primary focus is placed on how Arg199 modulates the electron transfer in NOS a role only revealed during the dynamics of the system. ..
- Gordon Research Conference: Lipoprotein Metabolism 2004Daniel Rader; Fiscal Year: 2004....
- ENZYMATIC REACTIONS OF PLASMA LIPOPROTEINSHenry J Pownall; Fiscal Year: 2010....
- Kern Aspen Lipid ConferenceAlan Tall; Fiscal Year: 2007..End of Abstract) [unreadable] [unreadable] [unreadable]..
- CONFERENCE ON ARTERIOSCLEROSIS AND VASCULAR BIOLOGYTrudy Forte; Fiscal Year: 2004..abstract_text> ..
- PRESERVATION OF HDL FUNCTION DURING EARLY ATHEROGENESISJOHN BIELICKI; Fiscal Year: 2002..Moreover, the research will uncover novel mechanisms for preserving HDL/LCAT function that can be utilized therapeutically to fight the onset of cardiovascular disease. ..
- Mentored Career Development in Patient Oriented ResearchDaniel Rader; Fiscal Year: 2006..abstract_text> ..
- HDL metabolism: Influence of extracellular lipasesDaniel Rader; Fiscal Year: 2009....
- MECHANISM OF PI-RELATED DYSLIPIDEMIA AND ATHEROSCLEROSISDaniel Rader; Fiscal Year: 2004..These studies will provide novel insights into the mechanisms of PI-associated dyslipidemia and atherosclerosis. ..