transglutaminases

Summary

Summary: Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.

Top Publications

  1. ncbi The cornified envelope: a model of cell death in the skin
    Eleonora Candi
    Biochemistry Laboratory, IDI IRCCS, c o Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
    Nat Rev Mol Cell Biol 6:328-40. 2005
  2. ncbi Tissue transglutaminase links TGF-β, epithelial to mesenchymal transition and a stem cell phenotype in ovarian cancer
    L Cao
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Oncogene 31:2521-34. 2012
  3. ncbi Transglutaminases: crosslinking enzymes with pleiotropic functions
    Laszlo Lorand
    Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Nat Rev Mol Cell Biol 4:140-56. 2003
  4. ncbi TG2, a novel extracellular protein with multiple functions
    Zhuo Wang
    School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B47ET, UK
    Amino Acids 42:939-49. 2012
  5. pmc Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin
    S S Akimov
    Department of Biochemistry, American Red Cross, Rockville, Maryland 20855, USA
    J Cell Biol 148:825-38. 2000
  6. ncbi Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
    Ivor D Hill
    North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Flourtown, PA 19031, USA
    J Pediatr Gastroenterol Nutr 40:1-19. 2005
  7. ncbi Transglutaminases and disease: lessons from genetically engineered mouse models and inherited disorders
    Siiri E Iismaa
    Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute and Universityof New South Wales, Sydney, New South Wales 2010, Australia
    Physiol Rev 89:991-1023. 2009
  8. pmc Tissue transglutaminase promotes drug resistance and invasion by inducing mesenchymal transition in mammary epithelial cells
    Anupam Kumar
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 5:e13390. 2010
  9. ncbi Phosphorylation of histones by tissue transglutaminase
    Suresh Mishra
    Department of Physiology, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada
    J Biol Chem 281:5532-8. 2006
  10. ncbi Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine
    Marcela V Karpuj
    Department of Neurological Sciences, Stanford University, Stanford, California, USA
    Nat Med 8:143-9. 2002

Research Grants

Detail Information

Publications324 found, 100 shown here

  1. ncbi The cornified envelope: a model of cell death in the skin
    Eleonora Candi
    Biochemistry Laboratory, IDI IRCCS, c o Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
    Nat Rev Mol Cell Biol 6:328-40. 2005
    ..and consists of keratins that are enclosed within an insoluble amalgam of proteins, which are crosslinked by transglutaminases and surrounded by a lipid envelope...
  2. ncbi Tissue transglutaminase links TGF-β, epithelial to mesenchymal transition and a stem cell phenotype in ovarian cancer
    L Cao
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Oncogene 31:2521-34. 2012
    ..Furthermore, CD44+/CD117+ cells isolated from human ovarian tumors express high levels of TG2. In summary, TGF-β-induced TG2 enhances ovarian tumor metastasis by inducing EMT and a cancer stem cell phenotype...
  3. ncbi Transglutaminases: crosslinking enzymes with pleiotropic functions
    Laszlo Lorand
    Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Nat Rev Mol Cell Biol 4:140-56. 2003
    ..These reactions--which are catalysed by transglutaminases--endow the resulting supramolecular structure with extra rigidity and resistance against proteolytic ..
  4. ncbi TG2, a novel extracellular protein with multiple functions
    Zhuo Wang
    School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B47ET, UK
    Amino Acids 42:939-49. 2012
    ..These include metastatic cancer, tissue fibrosis and coeliac disease, thus increasing its attractiveness as both a therapeutic target and diagnostic marker...
  5. pmc Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin
    S S Akimov
    Department of Biochemistry, American Red Cross, Rockville, Maryland 20855, USA
    J Cell Biol 148:825-38. 2000
    ..Together our results demonstrate that tissue transglutaminase mediates the interaction of integrins with fibronectin, thereby acting as an integrin-associated coreceptor to promote cell adhesion and spreading...
  6. ncbi Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
    Ivor D Hill
    North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Flourtown, PA 19031, USA
    J Pediatr Gastroenterol Nutr 40:1-19. 2005
    ..This document represents the official recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition on the diagnosis and treatment of celiac disease in children and adolescents...
  7. ncbi Transglutaminases and disease: lessons from genetically engineered mouse models and inherited disorders
    Siiri E Iismaa
    Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute and Universityof New South Wales, Sydney, New South Wales 2010, Australia
    Physiol Rev 89:991-1023. 2009
    ..The review focuses on FXIII-A, TG1, TG2, TG5, and protein 4.2, as mice deficient in TG3, TG4, TG6, or TG7 have not yet been reported, nor have mutations in these proteins been linked to human disease...
  8. pmc Tissue transglutaminase promotes drug resistance and invasion by inducing mesenchymal transition in mammary epithelial cells
    Anupam Kumar
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 5:e13390. 2010
    ..Overall, our studies show that aberrant expression of TG2 is sufficient for inducing EMT in epithelial cells and establish a strong link between TG2 expression and progression of metastatic breast disease...
  9. ncbi Phosphorylation of histones by tissue transglutaminase
    Suresh Mishra
    Department of Physiology, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada
    J Biol Chem 281:5532-8. 2006
    ..These studies suggest a novel role for TG2 in the regulation of chromatin structure and function...
  10. ncbi Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine
    Marcela V Karpuj
    Department of Neurological Sciences, Stanford University, Stanford, California, USA
    Nat Med 8:143-9. 2002
    ..Inhibition of TGase provides a new treatment strategy for HD and other polyglutamine diseases...
  11. ncbi Biochemical, structural, and transglutaminase substrate properties of human loricrin, the major epidermal cornified cell envelope protein
    E Candi
    Skin Biology Branch, NIAMS, National Institutes of Health, Bethesda, Maryland 20892 2775, USA
    J Biol Chem 270:26382-90. 1995
    ..Failure to cross-link loricrin by TGase 1 may explain the phenotype of lamellar ichthyosis, a disease caused by mutations in the TGase 1 gene...
  12. ncbi Cell surface localization of tissue transglutaminase is dependent on a fibronectin-binding site in its N-terminal beta-sandwich domain
    C A Gaudry
    Department of Life Sciences, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, United Kingdom
    J Biol Chem 274:30707-14. 1999
    ..These results demonstrate that tTG binds to the pericellular fibronectin coat of cells via its N-terminal beta-sandwich domain and that this interaction is crucial for cell surface association of tTG...
  13. ncbi Tissue transglutaminase and the stress response
    R Ientile
    Department of Biochemical, Physiological and Nutritional Sciences, University of Messina, Messina, Italy
    Amino Acids 33:385-94. 2007
    ..These findings agree with a postulated role for transglutaminases in molecular mechanisms involved in several diseases suggesting that cross-linking reactions could be a ..
  14. ncbi The role of tissue transglutaminase in cell-matrix interactions
    Evgeny A Zemskov
    Department of Biochemistry and Molecular Biology, Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Front Biosci 11:1057-76. 2006
    ..Understanding molecular interactions and enzymatic activities of tTG will gain further insights into the role of this protein in normal human physiology and various pathological conditions...
  15. ncbi Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy
    L Yuan
    Department of Neurological Surgery, Washington University School of Medicine, St Louis, MO, USA
    Oncogene 26:2563-73. 2007
    ....
  16. ncbi Prognostic significance of tissue transglutaminase in drug resistant and metastatic breast cancer
    Kapil Mehta
    Department of Experimental Therapeutics Unit 422, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 10:8068-76. 2004
    ..3.2.13). Because the drug-resistant and metastatic phenotypes are thought to share some common pathways, we sought to determine whether metastatic breast cancer cells express high levels of TG2...
  17. ncbi Tissue transglutaminase in normal and abnormal wound healing: review article
    E A M Verderio
    School of Science, Nottingham Trent University, Nottingham, United Kingdom
    Amino Acids 26:387-404. 2004
    ....
  18. pmc Increased prevalence and mortality in undiagnosed celiac disease
    Alberto Rubio-Tapia
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 137:88-93. 2009
    ..The historical prevalence and long-term outcome of undiagnosed celiac disease (CD) are unknown. We investigated the long-term outcome of undiagnosed CD and whether the prevalence of undiagnosed CD has changed during the past 50 years...
  19. ncbi Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applications
    R J Collighan
    School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK
    Amino Acids 36:659-70. 2009
    ..The medical applications of TG2 are further expanded by detailing the use of transglutaminase cross-linking in the development of novel biocompatible biomaterials for use in soft and hard tissue repair...
  20. ncbi Epithelial-to-mesenchymal transition and ovarian tumor progression induced by tissue transglutaminase
    Minghai Shao
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer Res 69:9192-201. 2009
    ..Highly expressed in ovarian tumors, TG2 promotes EMT and enhances ovarian tumor metastasis by activating oncogenic signaling...
  21. ncbi Transglutaminase 2: a multi-functional protein in multiple subcellular compartments
    Donghyun Park
    Department of Molecular and Cellular Biochemistry, Vascular System Research Center, Kangwon National University School of Medicine, Chuncheon, Kangwon Do, 200 701, Republic of Korea
    Amino Acids 39:619-31. 2010
    ..In this review, the biological functions and molecular interactions of TG2 will be discussed in the context of the unique environments of the subcellular compartments to which TG2 localizes...
  22. ncbi A homolog of Drosophila grainy head is essential for epidermal integrity in mice
    Stephen B Ting
    Rotary Bone Marrow Research Laboratories, c o Royal Melbourne Hospital Post Office, Grattan Street, Parkville, Victoria, Australia 3050
    Science 308:411-3. 2005
    ..These findings suggest that the functional mechanisms involving protein cross-linking that maintain the epidermal barrier and induce tissue repair are conserved across 700 million years of evolution...
  23. pmc Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation
    Nils Paulmann
    Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS Biol 7:e1000229. 2009
    ..In elucidating the underlying mechanism further, we demonstrate the covalent coupling of 5-HT by transglutaminases during insulin exocytosis to two key players in insulin secretion, the small GTPases Rab3a and Rab27a...
  24. ncbi Transglutaminase 2: an enigmatic enzyme with diverse functions
    Laszlo Fesus
    Dept of Biochemistry and Molecular Biology, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, H 4012, Debrecen, Hungary
    Trends Biochem Sci 27:534-9. 2002
    ..An important role for the enzyme in the pathogenesis of coeliac disease, fibrosis and neurodegenerative disorders has also been demonstrated, making TG2 an important therapeutic target...
  25. ncbi Celiac disease: antibody recognition against native and selectively deamidated gliadin peptides
    M Aleanzi
    Cátedra de Bioquímica Básica de Macromoléculas, INTEBIO, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Pje el Pozo CC 242, 3000 Santa Fe, Argentina
    Clin Chem 47:2023-8. 2001
    ..We examined the possibility that these modified peptides could be more specific epitopes for circulating antibodies than are native peptides...
  26. pmc Extracellular TG2: emerging functions and regulation
    Alexey M Belkin
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    FEBS J 278:4704-16. 2011
    ..This review summarizes and assesses recent research into the emerging functions and regulation of extracellular TG2...
  27. pmc Characterization of heparin-binding site of tissue transglutaminase: its importance in cell surface targeting, matrix deposition, and cell signaling
    Zhuo Wang
    School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, United Kingdom
    J Biol Chem 287:13063-83. 2012
    ..A novel regulatory mechanism for TG2 translocation into the extracellular compartment that depends upon TG2 conformation and the binding of HS is proposed...
  28. ncbi Current concepts of celiac disease pathogenesis
    D Schuppan
    First Department of Medicine, University of Erlangen Nuernberg, Erlangen, Germany
    Gastroenterology 119:234-42. 2000
    ..Long-standing untreated celiac disease, even if clinically silent, predisposes for other autoimmune diseases. Therefore, population screening for immunoglobulin A antibodies to tissue transglutaminase seems justified...
  29. pmc Epidermal growth factor receptor-mediated tissue transglutaminase overexpression couples acquired tumor necrosis factor-related apoptosis-inducing ligand resistance and migration through c-FLIP and MMP-9 proteins in lung cancer cells
    Zi Li
    Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    J Biol Chem 286:21164-72. 2011
    ..Because TGM2 couples TRAIL resistance and cell migration, it could be a molecular target for circumventing acquired chemoresistance and metastasis in lung cancer...
  30. pmc Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes
    Evgeny A Zemskov
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e19414. 2011
    ..These findings begin to unravel the unconventional mechanism of tTG secretion which utilizes the long loop of endosomal recycling pathway and indicate involvement of endosomal trafficking in non-classical protein secretion...
  31. ncbi Structural basis for gluten intolerance in celiac sprue
    Lu Shan
    Department of Chemical Engineering, Stanford University, Stanford, CA 94305 5025, USA
    Science 297:2275-9. 2002
    ..The peptide could be detoxified in in vitro and in vivo assays by exposure to a bacterial prolyl endopeptidase, suggesting a strategy for oral peptidase supplement therapy for Celiac Sprue...
  32. ncbi Transglutaminases in skin epidermis
    Kiyotaka Hitomi
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya, 464 8601, Japan
    Eur J Dermatol 15:313-9. 2005
    ..Therefore, disorder of the TGase activity results in an irregular phenotype in the skin. In this review, the expression, regulation, and function of these TGases in the skin epidermis are focused...
  33. ncbi Mutations of keratinocyte transglutaminase in lamellar ichthyosis
    M Huber
    Department of Dermatology, Centre Hospitalier Universitaire Vandois CHUV, Hôpital de Beaumont, Lausanne, Switzerland
    Science 267:525-8. 1995
    ..These data suggest that defects in TGK cause lamellar ichthyosis and that intact cross-linkage of cornified cell envelopes is required for epidermal tissue homeostasis...
  34. pmc Clinical and biological significance of tissue transglutaminase in ovarian carcinoma
    Jee Young Hwang
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 68:5849-58. 2008
    ..Taken together, these findings indicate that TG2 overexpression is an adverse prognostic factor in ovarian carcinoma and TG2 targeting may be an attractive therapeutic approach...
  35. ncbi Mutations in the gene for transglutaminase 1 in autosomal recessive lamellar ichthyosis
    L J Russell
    Genetic Studies Section, National Institute of Arthritis and Musculoskeletal and Skin Disease, NIH, Bethesda, Maryland 20892 2757, USA
    Nat Genet 9:279-83. 1995
    ..We hypothesize that these mutations adversely affect formation of crosslinks essential in production of cornified cell envelopes and a normal stratum corneum layer of the skin...
  36. pmc Heparan sulfate proteoglycans are receptors for the cell-surface trafficking and biological activity of transglutaminase-2
    Alessandra Scarpellini
    School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, United Kingdom
    J Biol Chem 284:18411-23. 2009
    ..We propose that the membrane trafficking of TG2, and hence its extracellular activity, is linked to TG2 binding to cell-surface HSPG...
  37. ncbi Autoantibodies against epidermal transglutaminase are a sensitive diagnostic marker in patients with dermatitis herpetiformis on a normal or gluten-free diet
    Christian Rose
    Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    J Am Acad Dermatol 61:39-43. 2009
    ..Patients with DH demonstrate circulating IgA antibodies against epidermal transglutaminase (eTG) and tissue transglutaminase (tTG). It has been suggested that eTG is the autoantigen of DH...
  38. pmc Tissue transglutaminase is an essential participant in the epidermal growth factor-stimulated signaling pathway leading to cancer cell migration and invasion
    Marc A Antonyak
    Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 284:17914-25. 2009
    ..These findings demonstrate that TGase plays a key role in cancer cell motility and invasiveness and represents a previously unappreciated participant in the EGF pathway that stimulates these processes in cancer cells...
  39. pmc Intracellular localization and conformational state of transglutaminase 2: implications for cell death
    Soner Gundemir
    Department of Pharmacology and Physiology, University of Rochester, Rochester, NY, USA
    PLoS ONE 4:e6123. 2009
    ..In addition, nuclear localization of TG2 generally plays a key role in its protective function against cell death processes, either counteracting the detrimental effect or strengthening the protective role of the protein...
  40. pmc Cell surface transglutaminase promotes RhoA activation via integrin clustering and suppression of the Src-p190RhoGAP signaling pathway
    Anna Janiak
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Biol Cell 17:1606-19. 2006
    ..Together, these findings show that surface tTG amplifies integrin-mediated signaling to RhoA/ROCK via integrin clustering and down-regulation of the Src-p190RhoGAP regulatory pathway...
  41. ncbi Increased expression of tissue transglutaminase in pancreatic ductal adenocarcinoma and its implications in drug resistance and metastasis
    Amit Verma
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 66:10525-33. 2006
    ..These results show for the first time that elevated expression of TG2 can induce constitutive activation of FAK and thus may contribute to the development of drug resistance and invasive phenotypes in PDAC...
  42. ncbi Implications of increased tissue transglutaminase (TG2) expression in drug-resistant breast cancer (MCF-7) cells
    J F Herman
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Oncogene 25:3049-58. 2006
    ..We conclude that the expression of TG2 in breast cancer cells contributes to the development of the drug-resistance phenotype by promoting interaction between integrins and Fn...
  43. ncbi Enhanced peritoneal ovarian tumor dissemination by tissue transglutaminase
    Minati Satpathy
    Department of Medicine, Indiana University School of Medicine, 535 Barnhill Drive, RT 473, Indianapolis, IN 46202, USA
    Cancer Res 67:7194-202. 2007
    ..Highly expressed in ovarian tumors, TG2 facilitates i.p. tumor dissemination by enhancing cell adhesion to the extracellular matrix and modulating beta(1) integrin subunit expression...
  44. pmc Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity
    Shenping Liu
    Department of Chemistry, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 99:2743-7. 2002
    ..Although the transamidation active site is similar to those of other known transglutaminases, the guanine nucleotide-binding site of TG differs markedly from other G proteins...
  45. pmc Specificity of tissue transglutaminase explains cereal toxicity in celiac disease
    L Willemijn Vader
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, 2300 RC Leiden, Netherlands
    J Exp Med 195:643-9. 2002
    ..This provides a rationale for the observation that celiac disease patients are intolerant to these cereal proteins but not to other common food proteins...
  46. ncbi Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease
    O Molberg
    Institute of Transplantation Immunology, Rikshospitalet, University of Oslo, Norway
    Nat Med 4:713-7. 1998
    ..Generation of epitopes by enzymatic modification is a new mechanism that may be relevant for breaking of tolerance and initiation of autoimmune disease...
  47. ncbi Tissue transglutaminase expression promotes cell attachment, invasion and survival in breast cancer cells
    L S Mangala
    Department of Experimental Therapeutics Unit 326, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 26:2459-70. 2007
    ..We conclude that TG2 expression in breast cancer cells plays an important role in the development of the metastatic phenotype...
  48. pmc Transglutaminase 2 undergoes a large conformational change upon activation
    Daniel M Pinkas
    Department of Chemical Engineering, Stanford University, Stanford, California, United States of America
    PLoS Biol 5:e327. 2007
    ..Although vertebrate transglutaminases have been studied extensively, thus far all structurally characterized members of this family have been ..
  49. pmc Seroprevalence, correlates, and characteristics of undetected coeliac disease in England
    J West
    University of Nottingham, Division of Epidemiology and Public Health, Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Gut 52:960-5. 2003
    ..To examine the seroprevalence, correlates, and characteristics of undetected coeliac disease in a large adult population sample in Cambridge, UK...
  50. ncbi Implications of tissue transglutaminase expression in malignant melanoma
    Jansina Y Fok
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 5:1493-503. 2006
    ..Overall, our results suggest that TG2 expression contributes to the development of chemoresistance in malignant melanoma cells by exploiting integrin-mediated cell survival signaling pathways...
  51. pmc Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta
    I Nunes
    Department of Cell Biology, Kaplan Cancer Center, New York University Medical Center, New York 10016, USA
    J Cell Biol 136:1151-63. 1997
    ..This suggests that residues 294-441 are critical to the transglutaminase reactivity of LTBP-1S...
  52. ncbi Transglutaminase 2: a multi-tasking protein in the complex circuitry of inflammation and cancer
    Kapil Mehta
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Biochem Pharmacol 80:1921-9. 2010
    ..We discuss the contribution of TG2-regulated pathways to the development of drug resistance and progression to metastatic disease and the therapeutic potential of TG2 for treating advanced-stage cancer...
  53. ncbi Reversal of drug resistance in breast cancer cells by transglutaminase 2 inhibition and nuclear factor-kappaB inactivation
    Dae Seok Kim
    Molecular Oncology Branch, Division of Basic Sciences, Research Institute and Cancer Biostatistics Branch, Center for Clinical Trials, National Cancer Center, Goyang, Kyonggi Do, Republic of Korea
    Cancer Res 66:10936-43. 2006
    ..Therefore, increased expression of TGase 2 and subsequent activation of NF-kappaB may contribute to drug resistance in breast cancer cells independently of EGF signaling...
  54. ncbi Cell surface tissue transglutaminase is involved in adhesion and migration of monocytic cells on fibronectin
    S S Akimov
    Department of Biochemistry, The Holland Laboratory, American Red Cross, Rockville, MD 20855, USA
    Blood 98:1567-76. 2001
    ..Two structurally related transglutaminases, tTG and the A subunit of factor XIII (FXIIIA), are expressed on the surface of monocytic cells, whereas ..
  55. ncbi High level expression of Streptomyces mobaraensis transglutaminase in Corynebacterium glutamicum using a chimeric pro-region from Streptomyces cinnamoneus transglutaminase
    Masayo Date
    Institute of Life Sciences, Ajinomoto Co Inc, 1 1 Suzuki cho, Kawasaki ku, Kawasaki 210 8681, Japan
    J Biotechnol 110:219-26. 2004
    ..mobaraensis and Streptomyces cinnamoneus transglutaminases for the production of MTGase in C. glutamicum...
  56. pmc Transglutaminase 2 inhibits Rb binding of human papillomavirus E7 by incorporating polyamine
    Ju Hong Jeon
    Department of Biochemistry and Molecular Biology Aging and Apoptosis Research Center, Seoul National University College of Medicine, 28 Yongon Dong, Seoul 110 799, Korea
    EMBO J 22:5273-82. 2003
    ....
  57. pmc Anti-inflammatory effects of the R2 peptide, an inhibitor of transglutaminase 2, in a mouse model of allergic asthma, induced by ovalbumin
    Dae Yong Kim
    Department of Pharmacology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea
    Br J Pharmacol 162:210-25. 2011
    ..We examined whether the R2 peptide inhibited the expression of TGase 2 in a mouse model of inflammatory allergic asthma...
  58. ncbi Degradation of transglutaminase 2 by calcium-mediated ubiquitination responding to high oxidative stress
    Eui Man Jeong
    Department of Biochemistry and Molecular Biology Aging and Apoptosis Research Center AARC, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Republic of Korea
    FEBS Lett 583:648-54. 2009
    ..These results indicate that the role of TG2 in apoptosis depends on the level of calcium influx triggered by oxidative stress...
  59. ncbi Analysis of TGM1, ALOX12B, ALOXE3, NIPAL4 and CYP4F22 in autosomal recessive congenital ichthyosis from Galicia (NW Spain): evidence of founder effects
    L Rodríguez-Pazos
    Department of Dermatology, Faculty of Medicine, Complejo Hospitalario Universitario, SERGAS, 15782 Santiago de Compostela, Spain
    Br J Dermatol 165:906-11. 2011
    ..Mutations in six genes have been identified in autosomal recessive congenital ichthyosis (ARCI). To date, few studies have analysed the spectrum of these mutations in specific populations...
  60. ncbi New insights into the functions and localization of nuclear transglutaminase 2
    Ting Fang Kuo
    Chemical Biology Department, RIKEN Advanced Science Institute, Wako, Saitama, Japan
    FEBS J 278:4756-67. 2011
    ..Selective regulation of the expression, activity or localization of nuclear TG2 will be important for basic research, as well as clinical applications, suggesting a new era for this long-studied enzyme...
  61. ncbi Retinoic acid receptors and tissue-transglutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells
    S Joshi
    Department of Internal Medicine, Cardiovascular Research Institute, The Texas A and M University System Health Science Center, Temple, TX 76504, USA
    Oncogene 25:240-7. 2006
    ..In addition to the long-term effects of RA that are coupled with cell differentiation, short-term effects involve migration and invasion of neuroblastoma SH-SY5Y cells...
  62. ncbi Tissue transglutaminase (TG2) in cancer biology
    Lingegowda S Mangala
    The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Prog Exp Tumor Res 38:125-38. 2005
  63. pmc Pathogen entrapment by transglutaminase--a conserved early innate immune mechanism
    Zhi Wang
    Department of Molecular Biology and Functional Genomics, Stockholm University, Stockholm, Sweden
    PLoS Pathog 6:e1000763. 2010
    ..These findings will help to guide further strategies to reduce the damaging effects of clotting and enhance its beneficial contribution to immune reactions...
  64. ncbi Synthesis of potent water-soluble tissue transglutaminase inhibitors
    Martin Griffin
    School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK
    Bioorg Med Chem Lett 18:5559-62. 2008
    ..The lead compounds were prepared in four steps and exhibited potent activity against tissue transglutaminase...
  65. ncbi Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes. Mutation in brief no. 982. Online
    O Porzio
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Hum Mutat 28:1150. 2007
    ..We conclude that reduced TG2 activity can contribute to disorders of glucose metabolism possibly via an impairment of insulin secretion...
  66. ncbi Autoantibodies in gluten ataxia recognize a novel neuronal transglutaminase
    Marios Hadjivassiliou
    Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK
    Ann Neurol 64:332-43. 2008
    ..We have identified a novel neuronal transglutaminase isozyme and investigated whether this enzyme is the target of the immune response in patients with neurological dysfunction...
  67. ncbi Somatostatin analogues, a series of tissue transglutaminase inducers, as a new tool for therapy of mesenchimal tumors of the gastrointestinal tract
    G Palmieri
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    Amino Acids 32:395-400. 2007
    ....
  68. ncbi Therapeutic significance of elevated tissue transglutaminase expression in pancreatic cancer
    Amit Verma
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 14:2476-83. 2008
    ..Therefore, we examined therapeutic targeting of TG2 for inhibiting growth and metastasis of in vivo growing pancreatic ductal adenocarcinoma (PDAC) in nude mice...
  69. ncbi Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathway
    Aman P Mann
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 66:8788-95. 2006
    ..Therefore, TG2 may be an attractive alternate target for inhibiting constitutive NF-kappaB activation and rendering cancer cells sensitive to anticancer therapies...
  70. ncbi Antibodies against synthetic deamidated gliadin peptides and tissue transglutaminase for the identification of childhood celiac disease
    Daniel Agardh
    Unit of Diabetes and Celiac Disease, Department of Clinical Sciences Pediatrics, Lund University, Malmo, Sweden
    Clin Gastroenterol Hepatol 5:1276-81. 2007
    ..The aim was to evaluate immunoglobulin (Ig)A and IgG antibodies to synthetic deamidated gliadin peptides (DGP) and human tTG as screening markers for childhood celiac disease...
  71. pmc Tissue transglutaminase-induced alterations in extracellular matrix inhibit tumor invasion
    Lingegowda S Mangala
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Mol Cancer 4:33. 2005
    ..Two hundred archived samples from patients with breast cancer were studied for the TG2 expression. Also, in an in vitro model the invasive behavior of MDA-MB-231 cells in the presence or absence of exogenous TG2 was determined...
  72. ncbi Celiac disease IgA modulates vascular permeability in vitro through the activity of transglutaminase 2 and RhoA
    Essi Myrsky
    Pediatric Research Center, Medical School, University of Tampere, Tampere, Finland
    Cell Mol Life Sci 66:3375-85. 2009
    ....
  73. ncbi Essential function of transglutaminase and clotting protein in shrimp immunity
    Mary Beth Bacano Maningas
    Laboratory of Genome Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Minato, Tokyo 108 8477, Japan
    Mol Immunol 45:1269-75. 2008
    ..Challenge test with white spot virus and Vibrio penaecida revealed that TGase and CP are critical molecules for the immune function of shrimp against bacterial and viral infection...
  74. ncbi Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity
    Y van de Wal
    Department of Immunohaematology and Bloodbank, Leiden University Medical Center, The Netherlands
    J Immunol 161:1585-8. 1998
    ..Moreover, these modifications may lead to the amplification of gluten-specific T cell responses in the gut and consequently may be important for the development of CD...
  75. ncbi S100A7, S100A10, and S100A11 are transglutaminase substrates
    M Ruse
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, Ohio 44106 4970, USA
    Biochemistry 40:3167-73. 2001
    ..b>Transglutaminases are enzymes that catalyze the formation of covalent epsilon-(gamma-glutamyl)lysine bonds between protein-..
  76. ncbi Transglutaminase overexpression sensitizes neuronal cell lines to apoptosis by increasing mitochondrial membrane potential and cellular oxidative stress
    Mauro Piacentini
    Department of Biology, University of Rome Tor Vergata Rome, Italy
    J Neurochem 81:1061-72. 2002
    ..These results could also be of pathogenetic relevance for those diseases that are characterized by increased tTG and apoptotic rate together with impaired mitochondrial function, e.g. in some neurodegenerative disease...
  77. ncbi Serum cytokine elevations in celiac disease: association with disease presentation
    John Sanil Manavalan
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Hum Immunol 71:50-7. 2010
    ..001), IL-10 (p < 0.001) and inflammatory cytokines such as IL-1alpha (p < 0.001), IL-1beta (p < 0.005), and IL-8 (p < 0.05) was observed...
  78. ncbi Celiac disease serology in dermatitis herpetiformis. Which is the best option for detecting gluten sensitivity?
    Emilia Sugai
    Small Bowel Section, Department of Medicine, Hospital de Gastroenterología Dr Carlos Bonorino Udaondo, Buenos Aires, Argentina
    Acta Gastroenterol Latinoam 36:197-201. 2006
    ....
  79. pmc Role of protein transamidation in serotonin-induced proliferation and migration of pulmonary artery smooth muscle cells
    Yinglin Liu
    Rutgers University, Piscataway, New Jersey, USA
    Am J Respir Cell Mol Biol 44:548-55. 2011
    ....
  80. ncbi Transglutaminase autoantibodies in dermatitis herpetiformis and celiac sprue
    Eric V Marietta
    Department of Dermatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Invest Dermatol 128:332-5. 2008
    ..These results would indicate that intestinal damage is associated with the production of anti-tTG IgA and anti-TGe IgA in DH patients...
  81. pmc Tissue transgluaminase 2 expression in meningiomas
    Liya Yuan
    Department of Neurological Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Box 8057, St Louis, MO 63110, USA
    J Neurooncol 90:125-32. 2008
    ..KCC009 treatment promoted apoptosis and enhanced radiation sensitivity both in cultured IOMM-Lee meningioma cells and in meningioma tumor explants. These findings support a potential protective role for TG2 in meningiomas...
  82. pmc Transglutaminase-1 gene mutations in autosomal recessive congenital ichthyosis: summary of mutations (including 23 novel) and modeling of TGase-1
    Matthew L Herman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland 20892 4562, USA
    Hum Mutat 30:537-47. 2009
    ..In conclusion, this study expands the TGM1 mutation spectrum and summarizes the current knowledge of TGM1 mutations. The high frequency of mutated arginine codons in TGM1 may be due to the deamination of 5' methylated CpG dinucleotides...
  83. ncbi Identification of a preferred substrate peptide for transglutaminase 3 and detection of in situ activity in skin and hair follicles
    Asaka Yamane
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Japan
    FEBS J 277:3564-74. 2010
    b>Transglutaminases (TGases) are a family of enzymes that catalyze cross-linking reactions between proteins...
  84. ncbi Epidermal transglutaminase deposits in perilesional and uninvolved skin in patients with dermatitis herpetiformis
    Matthew R Donaldson
    J Invest Dermatol 127:1268-71. 2007
  85. ncbi Serum prevalence of celiac disease in children and adolescents with type 1 diabetes mellitus
    Jacqueline Araujo
    Endocrinologista pediatra, Instituto Materno Infantil de Pernambuco IMIP e Hospital das Clínicas, Recife, PE, Brasil
    J Pediatr (Rio J) 82:210-4. 2006
    ..The objective of this study was to evaluate the seroprevalence of celiac disease in children and adolescents with type 1 diabetes mellitus...
  86. pmc Celiac disease and transglutaminase 2: a model for posttranslational modification of antigens and HLA association in the pathogenesis of autoimmune disorders
    Ludvig M Sollid
    Centre for Immune Regulation and Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, 0027 Oslo, Norway
    Curr Opin Immunol 23:732-8. 2011
    ..This insight gives clues for understanding the involvement of PTMs in other autoimmune diseases...
  87. ncbi Complex formation between tissue transglutaminase II (tTG) and vascular endothelial growth factor receptor 2 (VEGFR-2): proposed mechanism for modulation of endothelial cell response to VEGF
    Rima Dardik
    Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer 52621, Israel
    Exp Cell Res 312:2973-82. 2006
    ....
  88. pmc Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary inflammation and fibrosis in bleomycin-treated mice
    Keunhee Oh
    Laboratory of Immunology, Department of Biomedical Sciences Transplantation Research Institute, Seoul National University College of Medicine, Seoul 110 799, Korea
    J Exp Med 208:1707-19. 2011
    ..Therefore, TG2 represents an interesting potential target for therapeutic intervention...
  89. pmc Assembly and function of a spore coat-associated transglutaminase of Bacillus subtilis
    Rita Zilhão
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras Codex, Portugal
    J Bacteriol 187:7753-64. 2005
    ..We also show that a multicopy allele of tgl causes increased assembly of Tgl and affects the assembly, structure, and functional properties of the coat...
  90. pmc Evidence that aberrant expression of tissue transglutaminase promotes stem cell characteristics in mammary epithelial cells
    Anupam Kumar
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e20701. 2011
    ..Taken together, these results suggested a new function for TG2 and revealed a novel mechanism responsible for promoting the stem cell characteristics in adult mammary epithelial cells...
  91. pmc Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1
    Kanji Furuya
    Genome Damage and Stability Centre, University of Sussex, Brighton, BN1 9RQ, UK
    Genes Dev 18:1154-64. 2004
    ..When the Rad9-T412/S423 are phosphorylated, Rad4(TOPBP1) coprecipitates with Rad3(ATR), suggesting that phosphorylation coordinates formation of an active checkpoint complex...
  92. ncbi Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro
    E Candi
    Biochemistry Laboratory, Istituto Dermopatico dell Immacolata Istituto di Ricerca e Cura a Carattere Scientifico, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    J Biol Chem 276:35014-23. 2001
    b>Transglutaminases (TGases) are seven enzymes, cross-linking proteins by gamma-glutamil-epsilon-lysine bonds, four of which are expressed in the skin...
  93. ncbi Transglutaminases in vascular biology: relevance for vascular remodeling and atherosclerosis
    Erik N T P Bakker
    Department of Medical Physics, Academic Medical Center, Amsterdam, The Netherlands
    J Vasc Res 45:271-8. 2008
    ..However, recent data suggest that Tgases play a role in several other processes in vascular biology. These newly discovered areas include endothelial barrier function, small artery remodeling, and atherosclerosis...
  94. ncbi Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses
    Phil Stephens
    Department of Oral Surgery, Medicine and Pathology, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XY, UK
    J Cell Sci 117:3389-403. 2004
    ..By virtue of its crosslinking activity, the enzyme plays a central role in regulating ECM remodelling...
  95. ncbi Novel interactions of TG2 with heparan sulfate proteoglycans: reflection on physiological implications
    E A M Verderio
    School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, UK
    Amino Acids 36:671-7. 2009
    ..Our latest findings have identified syndecan-4 as a possible binding and signalling partner of fibronectin-bound TG2 and support the idea that transglutaminase-2 and syndecan-4 act in synergy...
  96. ncbi Diagnostic challenges in celiac disease and the role of the tissue transglutaminase-neo-epitope
    Torsten Matthias
    AESKU KIPP INSTITUTE, Mikroforum Ring 3, 55234 Wendelsheim, Germany
    Clin Rev Allergy Immunol 38:298-301. 2010
    ..Recent research into the pathogenesis of CD, allowed us to identify a neo-antigen that appears to be the most promising serological tool for the detection of anti-tissue transglutaminase as well as anti-gliadin antibodies...
  97. ncbi Dermatitis herpetiformis: close to unravelling a disease
    Sarolta Karpati
    Department of Dermatology, Semmelweis University, Maria utca 41, 1085 Budapest, Hungary
    J Dermatol Sci 34:83-90. 2004
    ..The two transglutaminases are highly homologous, and therefore, cross reactivity of the two antibodies might explain why patients with ..
  98. ncbi Coeliac disease and gluten sensitivity
    R Troncone
    Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    J Intern Med 269:582-90. 2011
    ..Emphasis is given to specific autoantibodies as markers of the coeliac spectrum and to the hypothesis that innate epithelial stress can exist independently from adaptive intestinal immunity in gluten sensitivity...
  99. ncbi Dermatitis herpetiformis
    Sarolta Karpati
    Department of Dermatology, Venereology, and Dermatooncology, Semmelweis University, Budapest, Hungary
    Clin Dermatol 30:56-9. 2012
    ..Untreated DH patients should be regularly monitored for malabsorption and lymphomas. Associated autoimmune diseases are more common among DH patients. Family screening for gluten sensitivity is also strongly suggested...
  100. ncbi Activity of maize transglutaminase overexpressed in Escherichia coli inclusion bodies: an alternative to protein refolding
    Patricia Carvajal
    Dept of Molecular Genetics, Centre de Recerca Agrigenomica CRAG CSIC IRTA UAB, Jordi Girona Salgado 18 24, 08034 Barcelona, Spain
    Biotechnol Prog 27:232-40. 2011
    b>Transglutaminases (TGases) catalyze protein post-translational modification by ε-(γ-glutamyl) links and covalent polyamine conjugation...
  101. ncbi SUMOylation of tissue transglutaminase as link between oxidative stress and inflammation
    Alessandro Luciani
    Institute of Pediatrics, University of Foggia, Foggia, Italy
    J Immunol 183:2775-84. 2009
    ..Targeting TG2-SUMO interactions might represent a new option to control disease evolution in CF patients as well as in other chronic inflammatory diseases, neurodegenerative pathologies, and cancer...

Research Grants63

  1. Identification of transamidated proteins involved in cell death induction
    BASSAM M FRAIJ; Fiscal Year: 2012
    Transamidations are calcium-dependent reactions catalyzed by transglutaminase enzymes. Transglutaminases utilize the 3-carboxyamide group of peptide-bound glutamine residues as acyl donor, having a broad specificity for acceptor ..
  2. Molecular mechanisms of medial calcification: regulation by transglutaminase 2
    Maria Nurminskaya; Fiscal Year: 2012
    ..Additionally, our studies will broadly impact several medical fields in which both 2-catenin and transglutaminases have been implicated, ranging from cardiovascular disease to cancer and bone remodeling...
  3. Regulation of Apoptotic Envelope Formation by MTB in the Host Macrophage
    HEINZ GERNOT REMOLD; Fiscal Year: 2010
    ..with attenuated Mtb, but also an lorganizing principle required for cross-linking of the envelope by transglutaminases. In the presence of [protease inhibitors such as PAI-2 proteolytic degradation of annexin-1 resulting in an ..
  4. Regulation of osteoblast maturation by transglutaminases
    Maria Nurminskaya; Fiscal Year: 2010
    ..b>Transglutaminases TG2 and FXIIIa promote osteoblast differentiation in vitro, and expression of these proteins is restricted ..
  5. Candida albicans Adhesion and Candidiasis
    Janet F Staab; Fiscal Year: 2012
    ..between Hwp1 and an unidentified BEC surface co-substrate protein, catalyzed by a member of the family of transglutaminases (TGs)...
  6. Constrictor / Mitogen Induced Remodeling of Cerebral Arterioles
    JAY HUMPHREY; Fiscal Year: 2009
    ..in cerebral arterioles that result from blood clot associated constrictors, smooth muscle mitogens, and transglutaminases that are presented to the adventitial surface (as in SAH), with particular attention to expected short-term (..
  7. COAT-Platelets
    George Dale; Fiscal Year: 2005
    ..inhibitors including dansyl cadaverine, putrescine, and acetyl-casein, and a synthetic peptide substrate for transglutaminases is incorporated in COAT- platelets...
  8. REGULATION AND FUNCTION OF A MAJOR CELL ENVELOPE PROTEIN
    DENNIS ROOP; Fiscal Year: 1999
    ..bridges, and more importantly covalent cross-links between glutamine and lysine residues, catalyzed by transglutaminases (TGases). A major protein component of the CE has been recently characterized and it has been named loricrin...
  9. COAGULATION OF BLOOD
    Laszlo Lorand; Fiscal Year: 1999
    ..This is a revision of a proposal to continue support to study various aspects of the biochemistry of the transglutaminases, factor XIII and tissue transglutaminase...
  10. TISSUE TRANSGLUTAMINASE AND VASCULAR REPAIR
    Thomas Slaughter; Fiscal Year: 2001
    DESCRIPTION (Adapted from the applicant's abstract) The transglutaminases (TGases) comprise a gene superfamily responsible for stabilizing both inter- and intra-molecular protein linkages through the formation of N-E-(y-glutamyl)lysine ..
  11. ROLE OF TRANSGLUTAMINASE IN HORMONE INTERNALIZATION
    Peter Davies; Fiscal Year: 1991
    b>Transglutaminases are a group of enzymes that catalyze the covalent cross-linking of cellular proteins. We have been interested in the factors that regulate the expression of these enzymes in normal and leukemic myeloid cells...
  12. Proteins of Candida albicans-an AIDS-related Pathogen
    Paula Sundstrom; Fiscal Year: 2007
    ..The recognition of Hwpl as an adhesin and virulence factor and the involvement of mammalian transglutaminases in adhesion have posed important new questions and have opened new avenues of exploration that will benefit ..
  13. STRUCTURAL PROTEINS IN GENETIC DEFECTS OF EPIDERMIS
    Lowell Goldsmith; Fiscal Year: 1980
    ..b>Transglutaminases and their substrates in the epidermis are studied...
  14. HUNTINGTON PROTEIN AND THE HUNTINGTON'S DISEASE MUTATION
    Steven Hersch; Fiscal Year: 2003
    ..b>Transglutaminases have been hypothesized to catalyze aggregation and it has been suggested that the huntingtin aggregated may ..
  15. Matrix proteins promote matrix vesicle mineralization
    Ann Rosenthal; Fiscal Year: 2007
    ..The ultimate goal of this work is to understand the pathogenesis of calcium crystal formation in articular cartilage, so that specific therapies for this disabling disease can be designed. ..
  16. TRANSGLUTAMINASE PROMOTES CPPD DISEASE IN AGING JOINTS
    Ann Rosenthal; Fiscal Year: 2007
    ..These studies will contribute to our understanding of CPPD deposition disease, so that effective therapies for this common and disabling form of arthritis can be designed. ..
  17. Implications of Retinoid-Induced CD38 Antigen Expression
    Kapil Mehta; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  18. MOLECULAR DEFECTS OF FIBRIN STABILIZATION
    Laszlo Lorand; Fiscal Year: 2002
    ..on the factor XIII (fibrin stabilizing factor) and similarly acting transaminating enzyme systems, when transglutaminases become discharged from tissues into plasma, to complex pathological phenomena...
  19. Regularity Mechanisms of Aldosterone Secretion
    Wendy Bollag; Fiscal Year: 2006
    ..The complex interactions between AngII and serum K+ levels suggest that abnormalities in the glomerulosa cell response to either agonist, or both, may contribute to the development of some forms of hypertension. [unreadable] [unreadable]..
  20. OspA and autoimmunity in chronic Lyme disease
    Armin Alaedini; Fiscal Year: 2007
    ..Identification of specific immune reactivity to an autoantigen might also be useful as a diagnostic marker and for monitoring of disease activity in affected patients. [unreadable] [unreadable] [unreadable]..
  21. Tissue Transglutaminase in Neurologic Injury
    THUNG SHEN LAI; Fiscal Year: 2007
    ..The inhibitors will be used to investigate the role of TTG in the pathogenesis of expanded polyQ diseases. Current proposal will lead to new therapy for HD and other neurologic disorders. [unreadable] [unreadable] [unreadable]..
  22. PHOSPHOLIPASE D AND KERATINOCYTE DIFFERENTIATION
    Wendy Bollag; Fiscal Year: 2007
    ..abstract_text> ..
  23. Topical Treatment for Mild Psoriasis
    Wendy Bollag; Fiscal Year: 2007
    ..An effective, easy-to-use, low-cost therapy suitable for long-term relief would be a great boon. [unreadable] [unreadable] [unreadable] [unreadable]..
  24. Altering the pl of peptide vaccines to avoid anaphylaxis
    Edwin Liu; Fiscal Year: 2007
    ..It is hypothesized that alteration of the pl of peptides may be a generalizable technique to prevent peptide-induced anaphylaxis while retaining immunomodulatory capacity. ..
  25. Immune reactivity to synapsin in the neuropathy and ataxia of celiac disease
    Armin Alaedini; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  26. Arterial 5-HT Transporter Function
    Stephanie Watts; Fiscal Year: 2009
    ..abstract_text> ..
  27. THE CRES GENE IN REPRODUCTION
    Gail Cornwall; Fiscal Year: 2007
    ..Also, the newly purchased mass spec will enable on site protein analysis for the studies described above. In short, the environment at TTUHSC is exceptional and will fully support my proposed studies. ..
  28. Hybrid Drugs: Novel Pharmacotherapy for ADHD
    FRANK TARAZI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. AT1 Receptor Activating Autoantibodies and Preeclampsia
    Yang Xia; Fiscal Year: 2008
    ..This hypothesis has the ability to explain many features of this complex life threatening condition and immediately suggests diagnostic and therapeutic opportunities. ..
  30. Immune Response to Clostridium difficile
    Ciaran Kelly; Fiscal Year: 2008
    ..These specific aims are designed to advance further our knowledge of the immunobiology of C. difficile toxin-induced diarrhea and the mechanisms of immune protection in humans. [unreadable] [unreadable] [unreadable]..
  31. Hoxb13 in Skin Renewal and Repair
    Judith Mack; Fiscal Year: 2008
    ..abstract_text> ..
  32. KERATINOCYTE DIFFERENTIATION REGULATOR
    RICHARD ECKERT; Fiscal Year: 2008
    ..Specific Aim 3 is designed to assess the importance of TIG3 subcellular distribution for function, and Specific Aim 4 is designed to investigate the TIG3 role in vivo. ..
  33. Multifunctional reagents for proteomic analysis
    CHRISTIAN SCHONEICH; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  34. A HLA Mouse Model for Gluten Sensitivity and Enteropathy
    Joseph Murray; Fiscal Year: 2009
    ..abstract_text> ..
  35. Regulation of normal human IEL by NKG2D and IL-15
    Bana Jabri; Fiscal Year: 2010
    ....
  36. MAP KINASES REGULATE INVOLUCRIN GENE EXPRESSION
    Richard L Eckert; Fiscal Year: 2010
    ..It is hoped that a better understand of this cascade will lead to new and effective therapies for epidermal disease. ..
  37. SYNERGY BETWEEN SSRIS AND OVARIAN HORMONES
    NANCY MUMA; Fiscal Year: 2009
    ..The proposed studies may lead to novel targets for medications which affect the regulation of RGSZ-1 to treat women who suffer from hot flashes and mood disorders during menopause ..
  38. Protease-Mediated Events in Epidermal Differentiation
    RICHARD PRESLAND; Fiscal Year: 2006
    ..abstract_text> ..
  39. Mitochondiral enzymes/oxidative stress in Alzheimer's
    Gary Gibson; Fiscal Year: 2004
    ..These models will also provide systems to test the efficacy of approaches to limit or reverse the changes in mitochondria. ..
  40. Norepinephrine Transporters: Targets for ADHD
    FRANK TARAZI; Fiscal Year: 2004
    ..Expected findings should lead to novel compounds that can be developed as much needed innovative non-stimulant treatments for ADHD and other major neuropsychiatric disorders. ..
  41. SIGNAL TRANSDUCTION SYSTEMS IN ALZHEIMERS DISEASE
    Gary Gibson; Fiscal Year: 2003
    ..abstract_text> ..
  42. Novel pharmacotherapies for treatment of ADHD
    FRANK TARAZI; Fiscal Year: 2003
    ..Expected findings should evolve new principles and lead to novel compounds that can be used as much-needed innovative treatments for ADHD and other major neuropsychiatric disorders. ..
  43. MOLECULAR BASIS OF CALCIUM PYROPHOSPHATE DEPOSITION
    Ikuko Masuda; Fiscal Year: 2002
    ..It is hoped that these studies will lead to therapies to reduce ePPi accumulation and reduce subsequent cartilage degeneration. ..
  44. ANGIOSTATIN--MOLECULAR MECHANISMS AND INTERACTIONS
    DAVID SANE; Fiscal Year: 2002
    ..These studies will lead to a better understanding of the mechanisms of angiogenesis inhibition by angiostatin. ..
  45. PATHOGENIC MECHANISMS OF HELICOBACTER PYLORI GASTRITIS
    Ciaran Kelly; Fiscal Year: 2002
    ..Identifying H.pylori virulence factors which modulate host immune and inflammatory responses and determining their mechanisms of action are key to targeting new management strategies for this highly prevalent pathogen. ..
  46. HEMIDESMOSOMAL PROTEIN LINKAGE MAP BY TWO-HYBRID SYSTEM
    Sirpa Aho; Fiscal Year: 2002
    ..abstract_text> ..
  47. ROLE OF PRE FIBRILLAR AMYLOID IN ALZHEIMER'S DISEASE
    Dean Hartley; Fiscal Year: 2002
    ....
  48. Effects of antipsychotic drugs on brain and behavior
    FRANK TARAZI; Fiscal Year: 2005
    ..adult rats, and should evolve new principles for improved treatments for childhood-onset schizophrenia and other major pediatric psychiatric disorders. ..
  49. MECHANISMS OF LEUKOCYTE RECRUITMENT IN IBD
    Ciaran Kelly; Fiscal Year: 2005
    ..An in-depth, mechanistic understanding of the regulation of ENA-78 gene expression in human enterocytes may lead to novel therapeutic approaches to IBD. ..
  50. Nitrosourea-induced growth arrest and apoptotic pathways
    Kevin Brown; Fiscal Year: 2007
    ..Understanding the molecules, mechanisms and pathways that control cellular response to MNNG and other genotoxins is important in preventing cancer and improving our ability to design effective cancer therapeutics. ..
  51. The 10th Symposium of the International Diabetes Epidemiology Group
    Marian Rewers; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  52. GREEN TEA POLYPHENOL CHEMOPREVENTION IN KERATINOCYTES
    RICHARD ECKERT; Fiscal Year: 2006
    ..The central goal of this proposal is to gain new information regarding the mechanism of EGCG action. It is hoped that these studies lead to the design of new strategies for enhancing the effectiveness of these agents. ..
  53. OXIDANT/ANTIOXIDANT EFFECTS OF TGF BETA1 ON LUNG CELLS
    BARRY FANBURG; Fiscal Year: 2001
    ..We anticipate that the composite studies will help to establish cellular redox status as an important intermediary in the actions of TGFbeta1 that may contribute to remodeling of the lung in disease states. ..
  54. Neural Patterns of Visual Learning in Schizophrenia
    Nicola Cascella; Fiscal Year: 2006
    ..Enduring primary negative symptoms are also expected to prevent feedback-dependent changes in the cingulate cortex. [unreadable] [unreadable]..
  55. Localization of a type 1 diabetes susceptibility gene
    ELIZABETH ELLER; Fiscal Year: 2006
    ..This work could also provide an example for identifying susceptibility genes for other complex diseases. ..
  56. Beta-Amyloid Protofibrils Cause AD Neuronal Dysfunction
    Dean Hartley; Fiscal Year: 2006
    ..abstract_text> ..
  57. Integrin-Transglutaminase Associated and Cell Adhesion
    ALEXEY BELKIN; Fiscal Year: 2006
    ..Ultimately, this acquired knowledge will advance our understanding of basic mechanisms of cell-matrix interactions. ..
  58. THE CRES GENE IN REPRODUCTION
    Gail Cornwall; Fiscal Year: 2005
    ..abstract_text> ..
  59. REGULATION OF HYPOTHALAMIC SIGNALING BY RGS4 PROTEIN
    NANCY MUMA; Fiscal Year: 2001
    ....