Genomes and Genes
Summary: Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.
Publications324 found, 100 shown here
- The cornified envelope: a model of cell death in the skinEleonora Candi
Biochemistry Laboratory, IDI IRCCS, c o Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
Nat Rev Mol Cell Biol 6:328-40. 2005..and consists of keratins that are enclosed within an insoluble amalgam of proteins, which are crosslinked by transglutaminases and surrounded by a lipid envelope...
- Tissue transglutaminase links TGF-β, epithelial to mesenchymal transition and a stem cell phenotype in ovarian cancerL Cao
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Oncogene 31:2521-34. 2012..Furthermore, CD44+/CD117+ cells isolated from human ovarian tumors express high levels of TG2. In summary, TGF-β-induced TG2 enhances ovarian tumor metastasis by inducing EMT and a cancer stem cell phenotype...
- Transglutaminases: crosslinking enzymes with pleiotropic functionsLaszlo Lorand
Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
Nat Rev Mol Cell Biol 4:140-56. 2003..These reactions--which are catalysed by transglutaminases--endow the resulting supramolecular structure with extra rigidity and resistance against proteolytic ..
- TG2, a novel extracellular protein with multiple functionsZhuo Wang
School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B47ET, UK
Amino Acids 42:939-49. 2012..These include metastatic cancer, tissue fibrosis and coeliac disease, thus increasing its attractiveness as both a therapeutic target and diagnostic marker...
- Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectinS S Akimov
Department of Biochemistry, American Red Cross, Rockville, Maryland 20855, USA
J Cell Biol 148:825-38. 2000..Together our results demonstrate that tissue transglutaminase mediates the interaction of integrins with fibronectin, thereby acting as an integrin-associated coreceptor to promote cell adhesion and spreading...
- Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and NutritionIvor D Hill
North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Flourtown, PA 19031, USA
J Pediatr Gastroenterol Nutr 40:1-19. 2005..This document represents the official recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition on the diagnosis and treatment of celiac disease in children and adolescents...
- Transglutaminases and disease: lessons from genetically engineered mouse models and inherited disordersSiiri E Iismaa
Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute and Universityof New South Wales, Sydney, New South Wales 2010, Australia
Physiol Rev 89:991-1023. 2009..The review focuses on FXIII-A, TG1, TG2, TG5, and protein 4.2, as mice deficient in TG3, TG4, TG6, or TG7 have not yet been reported, nor have mutations in these proteins been linked to human disease...
- Tissue transglutaminase promotes drug resistance and invasion by inducing mesenchymal transition in mammary epithelial cellsAnupam Kumar
Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
PLoS ONE 5:e13390. 2010..Overall, our studies show that aberrant expression of TG2 is sufficient for inducing EMT in epithelial cells and establish a strong link between TG2 expression and progression of metastatic breast disease...
- Phosphorylation of histones by tissue transglutaminaseSuresh Mishra
Department of Physiology, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada
J Biol Chem 281:5532-8. 2006..These studies suggest a novel role for TG2 in the regulation of chromatin structure and function...
- Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamineMarcela V Karpuj
Department of Neurological Sciences, Stanford University, Stanford, California, USA
Nat Med 8:143-9. 2002..Inhibition of TGase provides a new treatment strategy for HD and other polyglutamine diseases...
- Biochemical, structural, and transglutaminase substrate properties of human loricrin, the major epidermal cornified cell envelope proteinE Candi
Skin Biology Branch, NIAMS, National Institutes of Health, Bethesda, Maryland 20892 2775, USA
J Biol Chem 270:26382-90. 1995..Failure to cross-link loricrin by TGase 1 may explain the phenotype of lamellar ichthyosis, a disease caused by mutations in the TGase 1 gene...
- Cell surface localization of tissue transglutaminase is dependent on a fibronectin-binding site in its N-terminal beta-sandwich domainC A Gaudry
Department of Life Sciences, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, United Kingdom
J Biol Chem 274:30707-14. 1999..These results demonstrate that tTG binds to the pericellular fibronectin coat of cells via its N-terminal beta-sandwich domain and that this interaction is crucial for cell surface association of tTG...
- Tissue transglutaminase and the stress responseR Ientile
Department of Biochemical, Physiological and Nutritional Sciences, University of Messina, Messina, Italy
Amino Acids 33:385-94. 2007..These findings agree with a postulated role for transglutaminases in molecular mechanisms involved in several diseases suggesting that cross-linking reactions could be a ..
- The role of tissue transglutaminase in cell-matrix interactionsEvgeny A Zemskov
Department of Biochemistry and Molecular Biology, Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Front Biosci 11:1057-76. 2006..Understanding molecular interactions and enzymatic activities of tTG will gain further insights into the role of this protein in normal human physiology and various pathological conditions...
- Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapyL Yuan
Department of Neurological Surgery, Washington University School of Medicine, St Louis, MO, USA
Oncogene 26:2563-73. 2007....
- Prognostic significance of tissue transglutaminase in drug resistant and metastatic breast cancerKapil Mehta
Department of Experimental Therapeutics Unit 422, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Clin Cancer Res 10:8068-76. 2004..3.2.13). Because the drug-resistant and metastatic phenotypes are thought to share some common pathways, we sought to determine whether metastatic breast cancer cells express high levels of TG2...
- Tissue transglutaminase in normal and abnormal wound healing: review articleE A M Verderio
School of Science, Nottingham Trent University, Nottingham, United Kingdom
Amino Acids 26:387-404. 2004....
- Increased prevalence and mortality in undiagnosed celiac diseaseAlberto Rubio-Tapia
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
Gastroenterology 137:88-93. 2009..The historical prevalence and long-term outcome of undiagnosed celiac disease (CD) are unknown. We investigated the long-term outcome of undiagnosed CD and whether the prevalence of undiagnosed CD has changed during the past 50 years...
- Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applicationsR J Collighan
School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK
Amino Acids 36:659-70. 2009..The medical applications of TG2 are further expanded by detailing the use of transglutaminase cross-linking in the development of novel biocompatible biomaterials for use in soft and hard tissue repair...
- Epithelial-to-mesenchymal transition and ovarian tumor progression induced by tissue transglutaminaseMinghai Shao
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
Cancer Res 69:9192-201. 2009..Highly expressed in ovarian tumors, TG2 promotes EMT and enhances ovarian tumor metastasis by activating oncogenic signaling...
- Transglutaminase 2: a multi-functional protein in multiple subcellular compartmentsDonghyun Park
Department of Molecular and Cellular Biochemistry, Vascular System Research Center, Kangwon National University School of Medicine, Chuncheon, Kangwon Do, 200 701, Republic of Korea
Amino Acids 39:619-31. 2010..In this review, the biological functions and molecular interactions of TG2 will be discussed in the context of the unique environments of the subcellular compartments to which TG2 localizes...
- A homolog of Drosophila grainy head is essential for epidermal integrity in miceStephen B Ting
Rotary Bone Marrow Research Laboratories, c o Royal Melbourne Hospital Post Office, Grattan Street, Parkville, Victoria, Australia 3050
Science 308:411-3. 2005..These findings suggest that the functional mechanisms involving protein cross-linking that maintain the epidermal barrier and induce tissue repair are conserved across 700 million years of evolution...
- Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylationNils Paulmann
Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
PLoS Biol 7:e1000229. 2009..In elucidating the underlying mechanism further, we demonstrate the covalent coupling of 5-HT by transglutaminases during insulin exocytosis to two key players in insulin secretion, the small GTPases Rab3a and Rab27a...
- Transglutaminase 2: an enigmatic enzyme with diverse functionsLaszlo Fesus
Dept of Biochemistry and Molecular Biology, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, H 4012, Debrecen, Hungary
Trends Biochem Sci 27:534-9. 2002..An important role for the enzyme in the pathogenesis of coeliac disease, fibrosis and neurodegenerative disorders has also been demonstrated, making TG2 an important therapeutic target...
- Celiac disease: antibody recognition against native and selectively deamidated gliadin peptidesM Aleanzi
Cátedra de Bioquímica Básica de Macromoléculas, INTEBIO, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Pje el Pozo CC 242, 3000 Santa Fe, Argentina
Clin Chem 47:2023-8. 2001..We examined the possibility that these modified peptides could be more specific epitopes for circulating antibodies than are native peptides...
- Extracellular TG2: emerging functions and regulationAlexey M Belkin
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
FEBS J 278:4704-16. 2011..This review summarizes and assesses recent research into the emerging functions and regulation of extracellular TG2...
- Characterization of heparin-binding site of tissue transglutaminase: its importance in cell surface targeting, matrix deposition, and cell signalingZhuo Wang
School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, United Kingdom
J Biol Chem 287:13063-83. 2012..A novel regulatory mechanism for TG2 translocation into the extracellular compartment that depends upon TG2 conformation and the binding of HS is proposed...
- Current concepts of celiac disease pathogenesisD Schuppan
First Department of Medicine, University of Erlangen Nuernberg, Erlangen, Germany
Gastroenterology 119:234-42. 2000..Long-standing untreated celiac disease, even if clinically silent, predisposes for other autoimmune diseases. Therefore, population screening for immunoglobulin A antibodies to tissue transglutaminase seems justified...
- Epidermal growth factor receptor-mediated tissue transglutaminase overexpression couples acquired tumor necrosis factor-related apoptosis-inducing ligand resistance and migration through c-FLIP and MMP-9 proteins in lung cancer cellsZi Li
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
J Biol Chem 286:21164-72. 2011..Because TGM2 couples TRAIL resistance and cell migration, it could be a molecular target for circumventing acquired chemoresistance and metastasis in lung cancer...
- Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomesEvgeny A Zemskov
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 6:e19414. 2011..These findings begin to unravel the unconventional mechanism of tTG secretion which utilizes the long loop of endosomal recycling pathway and indicate involvement of endosomal trafficking in non-classical protein secretion...
- Structural basis for gluten intolerance in celiac sprueLu Shan
Department of Chemical Engineering, Stanford University, Stanford, CA 94305 5025, USA
Science 297:2275-9. 2002..The peptide could be detoxified in in vitro and in vivo assays by exposure to a bacterial prolyl endopeptidase, suggesting a strategy for oral peptidase supplement therapy for Celiac Sprue...
- Transglutaminases in skin epidermisKiyotaka Hitomi
Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya, 464 8601, Japan
Eur J Dermatol 15:313-9. 2005..Therefore, disorder of the TGase activity results in an irregular phenotype in the skin. In this review, the expression, regulation, and function of these TGases in the skin epidermis are focused...
- Mutations of keratinocyte transglutaminase in lamellar ichthyosisM Huber
Department of Dermatology, Centre Hospitalier Universitaire Vandois CHUV, Hôpital de Beaumont, Lausanne, Switzerland
Science 267:525-8. 1995..These data suggest that defects in TGK cause lamellar ichthyosis and that intact cross-linkage of cornified cell envelopes is required for epidermal tissue homeostasis...
- Clinical and biological significance of tissue transglutaminase in ovarian carcinomaJee Young Hwang
Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 68:5849-58. 2008..Taken together, these findings indicate that TG2 overexpression is an adverse prognostic factor in ovarian carcinoma and TG2 targeting may be an attractive therapeutic approach...
- Mutations in the gene for transglutaminase 1 in autosomal recessive lamellar ichthyosisL J Russell
Genetic Studies Section, National Institute of Arthritis and Musculoskeletal and Skin Disease, NIH, Bethesda, Maryland 20892 2757, USA
Nat Genet 9:279-83. 1995..We hypothesize that these mutations adversely affect formation of crosslinks essential in production of cornified cell envelopes and a normal stratum corneum layer of the skin...
- Heparan sulfate proteoglycans are receptors for the cell-surface trafficking and biological activity of transglutaminase-2Alessandra Scarpellini
School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, United Kingdom
J Biol Chem 284:18411-23. 2009..We propose that the membrane trafficking of TG2, and hence its extracellular activity, is linked to TG2 binding to cell-surface HSPG...
- Autoantibodies against epidermal transglutaminase are a sensitive diagnostic marker in patients with dermatitis herpetiformis on a normal or gluten-free dietChristian Rose
Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, Lubeck, Germany
J Am Acad Dermatol 61:39-43. 2009..Patients with DH demonstrate circulating IgA antibodies against epidermal transglutaminase (eTG) and tissue transglutaminase (tTG). It has been suggested that eTG is the autoantigen of DH...
- Tissue transglutaminase is an essential participant in the epidermal growth factor-stimulated signaling pathway leading to cancer cell migration and invasionMarc A Antonyak
Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
J Biol Chem 284:17914-25. 2009..These findings demonstrate that TGase plays a key role in cancer cell motility and invasiveness and represents a previously unappreciated participant in the EGF pathway that stimulates these processes in cancer cells...
- Intracellular localization and conformational state of transglutaminase 2: implications for cell deathSoner Gundemir
Department of Pharmacology and Physiology, University of Rochester, Rochester, NY, USA
PLoS ONE 4:e6123. 2009..In addition, nuclear localization of TG2 generally plays a key role in its protective function against cell death processes, either counteracting the detrimental effect or strengthening the protective role of the protein...
- Cell surface transglutaminase promotes RhoA activation via integrin clustering and suppression of the Src-p190RhoGAP signaling pathwayAnna Janiak
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Mol Biol Cell 17:1606-19. 2006..Together, these findings show that surface tTG amplifies integrin-mediated signaling to RhoA/ROCK via integrin clustering and down-regulation of the Src-p190RhoGAP regulatory pathway...
- Increased expression of tissue transglutaminase in pancreatic ductal adenocarcinoma and its implications in drug resistance and metastasisAmit Verma
Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Res 66:10525-33. 2006..These results show for the first time that elevated expression of TG2 can induce constitutive activation of FAK and thus may contribute to the development of drug resistance and invasive phenotypes in PDAC...
- Implications of increased tissue transglutaminase (TG2) expression in drug-resistant breast cancer (MCF-7) cellsJ F Herman
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
Oncogene 25:3049-58. 2006..We conclude that the expression of TG2 in breast cancer cells contributes to the development of the drug-resistance phenotype by promoting interaction between integrins and Fn...
- Enhanced peritoneal ovarian tumor dissemination by tissue transglutaminaseMinati Satpathy
Department of Medicine, Indiana University School of Medicine, 535 Barnhill Drive, RT 473, Indianapolis, IN 46202, USA
Cancer Res 67:7194-202. 2007..Highly expressed in ovarian tumors, TG2 facilitates i.p. tumor dissemination by enhancing cell adhesion to the extracellular matrix and modulating beta(1) integrin subunit expression...
- Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activityShenping Liu
Department of Chemistry, Cornell University, Ithaca, NY 14853, USA
Proc Natl Acad Sci U S A 99:2743-7. 2002..Although the transamidation active site is similar to those of other known transglutaminases, the guanine nucleotide-binding site of TG differs markedly from other G proteins...
- Specificity of tissue transglutaminase explains cereal toxicity in celiac diseaseL Willemijn Vader
Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, 2300 RC Leiden, Netherlands
J Exp Med 195:643-9. 2002..This provides a rationale for the observation that celiac disease patients are intolerant to these cereal proteins but not to other common food proteins...
- Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac diseaseO Molberg
Institute of Transplantation Immunology, Rikshospitalet, University of Oslo, Norway
Nat Med 4:713-7. 1998..Generation of epitopes by enzymatic modification is a new mechanism that may be relevant for breaking of tolerance and initiation of autoimmune disease...
- Tissue transglutaminase expression promotes cell attachment, invasion and survival in breast cancer cellsL S Mangala
Department of Experimental Therapeutics Unit 326, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Oncogene 26:2459-70. 2007..We conclude that TG2 expression in breast cancer cells plays an important role in the development of the metastatic phenotype...
- Transglutaminase 2 undergoes a large conformational change upon activationDaniel M Pinkas
Department of Chemical Engineering, Stanford University, Stanford, California, United States of America
PLoS Biol 5:e327. 2007..Although vertebrate transglutaminases have been studied extensively, thus far all structurally characterized members of this family have been ..
- Seroprevalence, correlates, and characteristics of undetected coeliac disease in EnglandJ West
University of Nottingham, Division of Epidemiology and Public Health, Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
Gut 52:960-5. 2003..To examine the seroprevalence, correlates, and characteristics of undetected coeliac disease in a large adult population sample in Cambridge, UK...
- Implications of tissue transglutaminase expression in malignant melanomaJansina Y Fok
Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Mol Cancer Ther 5:1493-503. 2006..Overall, our results suggest that TG2 expression contributes to the development of chemoresistance in malignant melanoma cells by exploiting integrin-mediated cell survival signaling pathways...
- Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-betaI Nunes
Department of Cell Biology, Kaplan Cancer Center, New York University Medical Center, New York 10016, USA
J Cell Biol 136:1151-63. 1997..This suggests that residues 294-441 are critical to the transglutaminase reactivity of LTBP-1S...
- Transglutaminase 2: a multi-tasking protein in the complex circuitry of inflammation and cancerKapil Mehta
Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Biochem Pharmacol 80:1921-9. 2010..We discuss the contribution of TG2-regulated pathways to the development of drug resistance and progression to metastatic disease and the therapeutic potential of TG2 for treating advanced-stage cancer...
- Reversal of drug resistance in breast cancer cells by transglutaminase 2 inhibition and nuclear factor-kappaB inactivationDae Seok Kim
Molecular Oncology Branch, Division of Basic Sciences, Research Institute and Cancer Biostatistics Branch, Center for Clinical Trials, National Cancer Center, Goyang, Kyonggi Do, Republic of Korea
Cancer Res 66:10936-43. 2006..Therefore, increased expression of TGase 2 and subsequent activation of NF-kappaB may contribute to drug resistance in breast cancer cells independently of EGF signaling...
- Cell surface tissue transglutaminase is involved in adhesion and migration of monocytic cells on fibronectinS S Akimov
Department of Biochemistry, The Holland Laboratory, American Red Cross, Rockville, MD 20855, USA
Blood 98:1567-76. 2001..Two structurally related transglutaminases, tTG and the A subunit of factor XIII (FXIIIA), are expressed on the surface of monocytic cells, whereas ..
- High level expression of Streptomyces mobaraensis transglutaminase in Corynebacterium glutamicum using a chimeric pro-region from Streptomyces cinnamoneus transglutaminaseMasayo Date
Institute of Life Sciences, Ajinomoto Co Inc, 1 1 Suzuki cho, Kawasaki ku, Kawasaki 210 8681, Japan
J Biotechnol 110:219-26. 2004..mobaraensis and Streptomyces cinnamoneus transglutaminases for the production of MTGase in C. glutamicum...
- Transglutaminase 2 inhibits Rb binding of human papillomavirus E7 by incorporating polyamineJu Hong Jeon
Department of Biochemistry and Molecular Biology Aging and Apoptosis Research Center, Seoul National University College of Medicine, 28 Yongon Dong, Seoul 110 799, Korea
EMBO J 22:5273-82. 2003....
- Anti-inflammatory effects of the R2 peptide, an inhibitor of transglutaminase 2, in a mouse model of allergic asthma, induced by ovalbuminDae Yong Kim
Department of Pharmacology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea
Br J Pharmacol 162:210-25. 2011..We examined whether the R2 peptide inhibited the expression of TGase 2 in a mouse model of inflammatory allergic asthma...
- Degradation of transglutaminase 2 by calcium-mediated ubiquitination responding to high oxidative stressEui Man Jeong
Department of Biochemistry and Molecular Biology Aging and Apoptosis Research Center AARC, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Republic of Korea
FEBS Lett 583:648-54. 2009..These results indicate that the role of TG2 in apoptosis depends on the level of calcium influx triggered by oxidative stress...
- Analysis of TGM1, ALOX12B, ALOXE3, NIPAL4 and CYP4F22 in autosomal recessive congenital ichthyosis from Galicia (NW Spain): evidence of founder effectsL Rodríguez-Pazos
Department of Dermatology, Faculty of Medicine, Complejo Hospitalario Universitario, SERGAS, 15782 Santiago de Compostela, Spain
Br J Dermatol 165:906-11. 2011..Mutations in six genes have been identified in autosomal recessive congenital ichthyosis (ARCI). To date, few studies have analysed the spectrum of these mutations in specific populations...
- New insights into the functions and localization of nuclear transglutaminase 2Ting Fang Kuo
Chemical Biology Department, RIKEN Advanced Science Institute, Wako, Saitama, Japan
FEBS J 278:4756-67. 2011..Selective regulation of the expression, activity or localization of nuclear TG2 will be important for basic research, as well as clinical applications, suggesting a new era for this long-studied enzyme...
- Retinoic acid receptors and tissue-transglutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cellsS Joshi
Department of Internal Medicine, Cardiovascular Research Institute, The Texas A and M University System Health Science Center, Temple, TX 76504, USA
Oncogene 25:240-7. 2006..In addition to the long-term effects of RA that are coupled with cell differentiation, short-term effects involve migration and invasion of neuroblastoma SH-SY5Y cells...
- Tissue transglutaminase (TG2) in cancer biologyLingegowda S Mangala
The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Prog Exp Tumor Res 38:125-38. 2005
- Pathogen entrapment by transglutaminase--a conserved early innate immune mechanismZhi Wang
Department of Molecular Biology and Functional Genomics, Stockholm University, Stockholm, Sweden
PLoS Pathog 6:e1000763. 2010..These findings will help to guide further strategies to reduce the damaging effects of clotting and enhance its beneficial contribution to immune reactions...
- Synthesis of potent water-soluble tissue transglutaminase inhibitorsMartin Griffin
School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK
Bioorg Med Chem Lett 18:5559-62. 2008..The lead compounds were prepared in four steps and exhibited potent activity against tissue transglutaminase...
- Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes. Mutation in brief no. 982. OnlineO Porzio
Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
Hum Mutat 28:1150. 2007..We conclude that reduced TG2 activity can contribute to disorders of glucose metabolism possibly via an impairment of insulin secretion...
- Autoantibodies in gluten ataxia recognize a novel neuronal transglutaminaseMarios Hadjivassiliou
Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK
Ann Neurol 64:332-43. 2008..We have identified a novel neuronal transglutaminase isozyme and investigated whether this enzyme is the target of the immune response in patients with neurological dysfunction...
- Somatostatin analogues, a series of tissue transglutaminase inducers, as a new tool for therapy of mesenchimal tumors of the gastrointestinal tractG Palmieri
Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
Amino Acids 32:395-400. 2007....
- Therapeutic significance of elevated tissue transglutaminase expression in pancreatic cancerAmit Verma
Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Clin Cancer Res 14:2476-83. 2008..Therefore, we examined therapeutic targeting of TG2 for inhibiting growth and metastasis of in vivo growing pancreatic ductal adenocarcinoma (PDAC) in nude mice...
- Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathwayAman P Mann
Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Res 66:8788-95. 2006..Therefore, TG2 may be an attractive alternate target for inhibiting constitutive NF-kappaB activation and rendering cancer cells sensitive to anticancer therapies...
- Antibodies against synthetic deamidated gliadin peptides and tissue transglutaminase for the identification of childhood celiac diseaseDaniel Agardh
Unit of Diabetes and Celiac Disease, Department of Clinical Sciences Pediatrics, Lund University, Malmo, Sweden
Clin Gastroenterol Hepatol 5:1276-81. 2007..The aim was to evaluate immunoglobulin (Ig)A and IgG antibodies to synthetic deamidated gliadin peptides (DGP) and human tTG as screening markers for childhood celiac disease...
- Tissue transglutaminase-induced alterations in extracellular matrix inhibit tumor invasionLingegowda S Mangala
Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Mol Cancer 4:33. 2005..Two hundred archived samples from patients with breast cancer were studied for the TG2 expression. Also, in an in vitro model the invasive behavior of MDA-MB-231 cells in the presence or absence of exogenous TG2 was determined...
- Celiac disease IgA modulates vascular permeability in vitro through the activity of transglutaminase 2 and RhoAEssi Myrsky
Pediatric Research Center, Medical School, University of Tampere, Tampere, Finland
Cell Mol Life Sci 66:3375-85. 2009....
- Essential function of transglutaminase and clotting protein in shrimp immunityMary Beth Bacano Maningas
Laboratory of Genome Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Minato, Tokyo 108 8477, Japan
Mol Immunol 45:1269-75. 2008..Challenge test with white spot virus and Vibrio penaecida revealed that TGase and CP are critical molecules for the immune function of shrimp against bacterial and viral infection...
- Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivityY van de Wal
Department of Immunohaematology and Bloodbank, Leiden University Medical Center, The Netherlands
J Immunol 161:1585-8. 1998..Moreover, these modifications may lead to the amplification of gluten-specific T cell responses in the gut and consequently may be important for the development of CD...
- S100A7, S100A10, and S100A11 are transglutaminase substratesM Ruse
Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, Ohio 44106 4970, USA
Biochemistry 40:3167-73. 2001..b>Transglutaminases are enzymes that catalyze the formation of covalent epsilon-(gamma-glutamyl)lysine bonds between protein-..
- Transglutaminase overexpression sensitizes neuronal cell lines to apoptosis by increasing mitochondrial membrane potential and cellular oxidative stressMauro Piacentini
Department of Biology, University of Rome Tor Vergata Rome, Italy
J Neurochem 81:1061-72. 2002..These results could also be of pathogenetic relevance for those diseases that are characterized by increased tTG and apoptotic rate together with impaired mitochondrial function, e.g. in some neurodegenerative disease...
- Serum cytokine elevations in celiac disease: association with disease presentationJohn Sanil Manavalan
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Hum Immunol 71:50-7. 2010..001), IL-10 (p < 0.001) and inflammatory cytokines such as IL-1alpha (p < 0.001), IL-1beta (p < 0.005), and IL-8 (p < 0.05) was observed...
- Celiac disease serology in dermatitis herpetiformis. Which is the best option for detecting gluten sensitivity?Emilia Sugai
Small Bowel Section, Department of Medicine, Hospital de Gastroenterología Dr Carlos Bonorino Udaondo, Buenos Aires, Argentina
Acta Gastroenterol Latinoam 36:197-201. 2006....
- Role of protein transamidation in serotonin-induced proliferation and migration of pulmonary artery smooth muscle cellsYinglin Liu
Rutgers University, Piscataway, New Jersey, USA
Am J Respir Cell Mol Biol 44:548-55. 2011....
- Transglutaminase autoantibodies in dermatitis herpetiformis and celiac sprueEric V Marietta
Department of Dermatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
J Invest Dermatol 128:332-5. 2008..These results would indicate that intestinal damage is associated with the production of anti-tTG IgA and anti-TGe IgA in DH patients...
- Tissue transgluaminase 2 expression in meningiomasLiya Yuan
Department of Neurological Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Box 8057, St Louis, MO 63110, USA
J Neurooncol 90:125-32. 2008..KCC009 treatment promoted apoptosis and enhanced radiation sensitivity both in cultured IOMM-Lee meningioma cells and in meningioma tumor explants. These findings support a potential protective role for TG2 in meningiomas...
- Transglutaminase-1 gene mutations in autosomal recessive congenital ichthyosis: summary of mutations (including 23 novel) and modeling of TGase-1Matthew L Herman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland 20892 4562, USA
Hum Mutat 30:537-47. 2009..In conclusion, this study expands the TGM1 mutation spectrum and summarizes the current knowledge of TGM1 mutations. The high frequency of mutated arginine codons in TGM1 may be due to the deamination of 5' methylated CpG dinucleotides...
- Identification of a preferred substrate peptide for transglutaminase 3 and detection of in situ activity in skin and hair folliclesAsaka Yamane
Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Japan
FEBS J 277:3564-74. 2010b>Transglutaminases (TGases) are a family of enzymes that catalyze cross-linking reactions between proteins...
- Epidermal transglutaminase deposits in perilesional and uninvolved skin in patients with dermatitis herpetiformisMatthew R Donaldson
J Invest Dermatol 127:1268-71. 2007
- Serum prevalence of celiac disease in children and adolescents with type 1 diabetes mellitusJacqueline Araujo
Endocrinologista pediatra, Instituto Materno Infantil de Pernambuco IMIP e Hospital das Clínicas, Recife, PE, Brasil
J Pediatr (Rio J) 82:210-4. 2006..The objective of this study was to evaluate the seroprevalence of celiac disease in children and adolescents with type 1 diabetes mellitus...
- Celiac disease and transglutaminase 2: a model for posttranslational modification of antigens and HLA association in the pathogenesis of autoimmune disordersLudvig M Sollid
Centre for Immune Regulation and Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, 0027 Oslo, Norway
Curr Opin Immunol 23:732-8. 2011..This insight gives clues for understanding the involvement of PTMs in other autoimmune diseases...
- Complex formation between tissue transglutaminase II (tTG) and vascular endothelial growth factor receptor 2 (VEGFR-2): proposed mechanism for modulation of endothelial cell response to VEGFRima Dardik
Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer 52621, Israel
Exp Cell Res 312:2973-82. 2006....
- Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary inflammation and fibrosis in bleomycin-treated miceKeunhee Oh
Laboratory of Immunology, Department of Biomedical Sciences Transplantation Research Institute, Seoul National University College of Medicine, Seoul 110 799, Korea
J Exp Med 208:1707-19. 2011..Therefore, TG2 represents an interesting potential target for therapeutic intervention...
- Assembly and function of a spore coat-associated transglutaminase of Bacillus subtilisRita Zilhão
Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras Codex, Portugal
J Bacteriol 187:7753-64. 2005..We also show that a multicopy allele of tgl causes increased assembly of Tgl and affects the assembly, structure, and functional properties of the coat...
- Evidence that aberrant expression of tissue transglutaminase promotes stem cell characteristics in mammary epithelial cellsAnupam Kumar
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
PLoS ONE 6:e20701. 2011..Taken together, these results suggested a new function for TG2 and revealed a novel mechanism responsible for promoting the stem cell characteristics in adult mammary epithelial cells...
- Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1Kanji Furuya
Genome Damage and Stability Centre, University of Sussex, Brighton, BN1 9RQ, UK
Genes Dev 18:1154-64. 2004..When the Rad9-T412/S423 are phosphorylated, Rad4(TOPBP1) coprecipitates with Rad3(ATR), suggesting that phosphorylation coordinates formation of an active checkpoint complex...
- Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitroE Candi
Biochemistry Laboratory, Istituto Dermopatico dell Immacolata Istituto di Ricerca e Cura a Carattere Scientifico, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
J Biol Chem 276:35014-23. 2001b>Transglutaminases (TGases) are seven enzymes, cross-linking proteins by gamma-glutamil-epsilon-lysine bonds, four of which are expressed in the skin...
- Transglutaminases in vascular biology: relevance for vascular remodeling and atherosclerosisErik N T P Bakker
Department of Medical Physics, Academic Medical Center, Amsterdam, The Netherlands
J Vasc Res 45:271-8. 2008..However, recent data suggest that Tgases play a role in several other processes in vascular biology. These newly discovered areas include endothelial barrier function, small artery remodeling, and atherosclerosis...
- Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responsesPhil Stephens
Department of Oral Surgery, Medicine and Pathology, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XY, UK
J Cell Sci 117:3389-403. 2004..By virtue of its crosslinking activity, the enzyme plays a central role in regulating ECM remodelling...
- Novel interactions of TG2 with heparan sulfate proteoglycans: reflection on physiological implicationsE A M Verderio
School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, UK
Amino Acids 36:671-7. 2009..Our latest findings have identified syndecan-4 as a possible binding and signalling partner of fibronectin-bound TG2 and support the idea that transglutaminase-2 and syndecan-4 act in synergy...
- Diagnostic challenges in celiac disease and the role of the tissue transglutaminase-neo-epitopeTorsten Matthias
AESKU KIPP INSTITUTE, Mikroforum Ring 3, 55234 Wendelsheim, Germany
Clin Rev Allergy Immunol 38:298-301. 2010..Recent research into the pathogenesis of CD, allowed us to identify a neo-antigen that appears to be the most promising serological tool for the detection of anti-tissue transglutaminase as well as anti-gliadin antibodies...
- Dermatitis herpetiformis: close to unravelling a diseaseSarolta Karpati
Department of Dermatology, Semmelweis University, Maria utca 41, 1085 Budapest, Hungary
J Dermatol Sci 34:83-90. 2004..The two transglutaminases are highly homologous, and therefore, cross reactivity of the two antibodies might explain why patients with ..
- Coeliac disease and gluten sensitivityR Troncone
Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
J Intern Med 269:582-90. 2011..Emphasis is given to specific autoantibodies as markers of the coeliac spectrum and to the hypothesis that innate epithelial stress can exist independently from adaptive intestinal immunity in gluten sensitivity...
- Dermatitis herpetiformisSarolta Karpati
Department of Dermatology, Venereology, and Dermatooncology, Semmelweis University, Budapest, Hungary
Clin Dermatol 30:56-9. 2012..Untreated DH patients should be regularly monitored for malabsorption and lymphomas. Associated autoimmune diseases are more common among DH patients. Family screening for gluten sensitivity is also strongly suggested...
- Activity of maize transglutaminase overexpressed in Escherichia coli inclusion bodies: an alternative to protein refoldingPatricia Carvajal
Dept of Molecular Genetics, Centre de Recerca Agrigenomica CRAG CSIC IRTA UAB, Jordi Girona Salgado 18 24, 08034 Barcelona, Spain
Biotechnol Prog 27:232-40. 2011b>Transglutaminases (TGases) catalyze protein post-translational modification by ε-(γ-glutamyl) links and covalent polyamine conjugation...
- SUMOylation of tissue transglutaminase as link between oxidative stress and inflammationAlessandro Luciani
Institute of Pediatrics, University of Foggia, Foggia, Italy
J Immunol 183:2775-84. 2009..Targeting TG2-SUMO interactions might represent a new option to control disease evolution in CF patients as well as in other chronic inflammatory diseases, neurodegenerative pathologies, and cancer...
- Identification of transamidated proteins involved in cell death inductionBASSAM M FRAIJ; Fiscal Year: 2012Transamidations are calcium-dependent reactions catalyzed by transglutaminase enzymes. Transglutaminases utilize the 3-carboxyamide group of peptide-bound glutamine residues as acyl donor, having a broad specificity for acceptor ..
- Molecular mechanisms of medial calcification: regulation by transglutaminase 2Maria Nurminskaya; Fiscal Year: 2012..Additionally, our studies will broadly impact several medical fields in which both 2-catenin and transglutaminases have been implicated, ranging from cardiovascular disease to cancer and bone remodeling...
- Regulation of Apoptotic Envelope Formation by MTB in the Host MacrophageHEINZ GERNOT REMOLD; Fiscal Year: 2010..with attenuated Mtb, but also an lorganizing principle required for cross-linking of the envelope by transglutaminases. In the presence of [protease inhibitors such as PAI-2 proteolytic degradation of annexin-1 resulting in an ..
- Regulation of osteoblast maturation by transglutaminasesMaria Nurminskaya; Fiscal Year: 2010..b>Transglutaminases TG2 and FXIIIa promote osteoblast differentiation in vitro, and expression of these proteins is restricted ..
- Candida albicans Adhesion and CandidiasisJanet F Staab; Fiscal Year: 2012..between Hwp1 and an unidentified BEC surface co-substrate protein, catalyzed by a member of the family of transglutaminases (TGs)...
- Constrictor / Mitogen Induced Remodeling of Cerebral ArteriolesJAY HUMPHREY; Fiscal Year: 2009..in cerebral arterioles that result from blood clot associated constrictors, smooth muscle mitogens, and transglutaminases that are presented to the adventitial surface (as in SAH), with particular attention to expected short-term (..
- COAT-PlateletsGeorge Dale; Fiscal Year: 2005..inhibitors including dansyl cadaverine, putrescine, and acetyl-casein, and a synthetic peptide substrate for transglutaminases is incorporated in COAT- platelets...
- REGULATION AND FUNCTION OF A MAJOR CELL ENVELOPE PROTEINDENNIS ROOP; Fiscal Year: 1999..bridges, and more importantly covalent cross-links between glutamine and lysine residues, catalyzed by transglutaminases (TGases). A major protein component of the CE has been recently characterized and it has been named loricrin...
- COAGULATION OF BLOODLaszlo Lorand; Fiscal Year: 1999..This is a revision of a proposal to continue support to study various aspects of the biochemistry of the transglutaminases, factor XIII and tissue transglutaminase...
- TISSUE TRANSGLUTAMINASE AND VASCULAR REPAIRThomas Slaughter; Fiscal Year: 2001DESCRIPTION (Adapted from the applicant's abstract) The transglutaminases (TGases) comprise a gene superfamily responsible for stabilizing both inter- and intra-molecular protein linkages through the formation of N-E-(y-glutamyl)lysine ..
- ROLE OF TRANSGLUTAMINASE IN HORMONE INTERNALIZATIONPeter Davies; Fiscal Year: 1991b>Transglutaminases are a group of enzymes that catalyze the covalent cross-linking of cellular proteins. We have been interested in the factors that regulate the expression of these enzymes in normal and leukemic myeloid cells...
- Proteins of Candida albicans-an AIDS-related PathogenPaula Sundstrom; Fiscal Year: 2007..The recognition of Hwpl as an adhesin and virulence factor and the involvement of mammalian transglutaminases in adhesion have posed important new questions and have opened new avenues of exploration that will benefit ..
- STRUCTURAL PROTEINS IN GENETIC DEFECTS OF EPIDERMISLowell Goldsmith; Fiscal Year: 1980..b>Transglutaminases and their substrates in the epidermis are studied...
- HUNTINGTON PROTEIN AND THE HUNTINGTON'S DISEASE MUTATIONSteven Hersch; Fiscal Year: 2003..b>Transglutaminases have been hypothesized to catalyze aggregation and it has been suggested that the huntingtin aggregated may ..
- Matrix proteins promote matrix vesicle mineralizationAnn Rosenthal; Fiscal Year: 2007..The ultimate goal of this work is to understand the pathogenesis of calcium crystal formation in articular cartilage, so that specific therapies for this disabling disease can be designed. ..
- TRANSGLUTAMINASE PROMOTES CPPD DISEASE IN AGING JOINTSAnn Rosenthal; Fiscal Year: 2007..These studies will contribute to our understanding of CPPD deposition disease, so that effective therapies for this common and disabling form of arthritis can be designed. ..
- Implications of Retinoid-Induced CD38 Antigen ExpressionKapil Mehta; Fiscal Year: 2006..unreadable] [unreadable]..
- MOLECULAR DEFECTS OF FIBRIN STABILIZATIONLaszlo Lorand; Fiscal Year: 2002..on the factor XIII (fibrin stabilizing factor) and similarly acting transaminating enzyme systems, when transglutaminases become discharged from tissues into plasma, to complex pathological phenomena...
- Regularity Mechanisms of Aldosterone SecretionWendy Bollag; Fiscal Year: 2006..The complex interactions between AngII and serum K+ levels suggest that abnormalities in the glomerulosa cell response to either agonist, or both, may contribute to the development of some forms of hypertension. [unreadable] [unreadable]..
- OspA and autoimmunity in chronic Lyme diseaseArmin Alaedini; Fiscal Year: 2007..Identification of specific immune reactivity to an autoantigen might also be useful as a diagnostic marker and for monitoring of disease activity in affected patients. [unreadable] [unreadable] [unreadable]..
- Tissue Transglutaminase in Neurologic InjuryTHUNG SHEN LAI; Fiscal Year: 2007..The inhibitors will be used to investigate the role of TTG in the pathogenesis of expanded polyQ diseases. Current proposal will lead to new therapy for HD and other neurologic disorders. [unreadable] [unreadable] [unreadable]..
- PHOSPHOLIPASE D AND KERATINOCYTE DIFFERENTIATIONWendy Bollag; Fiscal Year: 2007..abstract_text> ..
- Topical Treatment for Mild PsoriasisWendy Bollag; Fiscal Year: 2007..An effective, easy-to-use, low-cost therapy suitable for long-term relief would be a great boon. [unreadable] [unreadable] [unreadable] [unreadable]..
- Altering the pl of peptide vaccines to avoid anaphylaxisEdwin Liu; Fiscal Year: 2007..It is hypothesized that alteration of the pl of peptides may be a generalizable technique to prevent peptide-induced anaphylaxis while retaining immunomodulatory capacity. ..
- Immune reactivity to synapsin in the neuropathy and ataxia of celiac diseaseArmin Alaedini; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Arterial 5-HT Transporter FunctionStephanie Watts; Fiscal Year: 2009..abstract_text> ..
- THE CRES GENE IN REPRODUCTIONGail Cornwall; Fiscal Year: 2007..Also, the newly purchased mass spec will enable on site protein analysis for the studies described above. In short, the environment at TTUHSC is exceptional and will fully support my proposed studies. ..
- Hybrid Drugs: Novel Pharmacotherapy for ADHDFRANK TARAZI; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- AT1 Receptor Activating Autoantibodies and PreeclampsiaYang Xia; Fiscal Year: 2008..This hypothesis has the ability to explain many features of this complex life threatening condition and immediately suggests diagnostic and therapeutic opportunities. ..
- Immune Response to Clostridium difficileCiaran Kelly; Fiscal Year: 2008..These specific aims are designed to advance further our knowledge of the immunobiology of C. difficile toxin-induced diarrhea and the mechanisms of immune protection in humans. [unreadable] [unreadable] [unreadable]..
- Hoxb13 in Skin Renewal and RepairJudith Mack; Fiscal Year: 2008..abstract_text> ..
- KERATINOCYTE DIFFERENTIATION REGULATORRICHARD ECKERT; Fiscal Year: 2008..Specific Aim 3 is designed to assess the importance of TIG3 subcellular distribution for function, and Specific Aim 4 is designed to investigate the TIG3 role in vivo. ..
- Multifunctional reagents for proteomic analysisCHRISTIAN SCHONEICH; Fiscal Year: 2008..unreadable] [unreadable]..
- A HLA Mouse Model for Gluten Sensitivity and EnteropathyJoseph Murray; Fiscal Year: 2009..abstract_text> ..
- Regulation of normal human IEL by NKG2D and IL-15Bana Jabri; Fiscal Year: 2010....
- MAP KINASES REGULATE INVOLUCRIN GENE EXPRESSIONRichard L Eckert; Fiscal Year: 2010..It is hoped that a better understand of this cascade will lead to new and effective therapies for epidermal disease. ..
- SYNERGY BETWEEN SSRIS AND OVARIAN HORMONESNANCY MUMA; Fiscal Year: 2009..The proposed studies may lead to novel targets for medications which affect the regulation of RGSZ-1 to treat women who suffer from hot flashes and mood disorders during menopause ..
- Protease-Mediated Events in Epidermal DifferentiationRICHARD PRESLAND; Fiscal Year: 2006..abstract_text> ..
- Mitochondiral enzymes/oxidative stress in Alzheimer'sGary Gibson; Fiscal Year: 2004..These models will also provide systems to test the efficacy of approaches to limit or reverse the changes in mitochondria. ..
- Norepinephrine Transporters: Targets for ADHDFRANK TARAZI; Fiscal Year: 2004..Expected findings should lead to novel compounds that can be developed as much needed innovative non-stimulant treatments for ADHD and other major neuropsychiatric disorders. ..
- SIGNAL TRANSDUCTION SYSTEMS IN ALZHEIMERS DISEASEGary Gibson; Fiscal Year: 2003..abstract_text> ..
- Novel pharmacotherapies for treatment of ADHDFRANK TARAZI; Fiscal Year: 2003..Expected findings should evolve new principles and lead to novel compounds that can be used as much-needed innovative treatments for ADHD and other major neuropsychiatric disorders. ..
- MOLECULAR BASIS OF CALCIUM PYROPHOSPHATE DEPOSITIONIkuko Masuda; Fiscal Year: 2002..It is hoped that these studies will lead to therapies to reduce ePPi accumulation and reduce subsequent cartilage degeneration. ..
- ANGIOSTATIN--MOLECULAR MECHANISMS AND INTERACTIONSDAVID SANE; Fiscal Year: 2002..These studies will lead to a better understanding of the mechanisms of angiogenesis inhibition by angiostatin. ..
- PATHOGENIC MECHANISMS OF HELICOBACTER PYLORI GASTRITISCiaran Kelly; Fiscal Year: 2002..Identifying H.pylori virulence factors which modulate host immune and inflammatory responses and determining their mechanisms of action are key to targeting new management strategies for this highly prevalent pathogen. ..
- HEMIDESMOSOMAL PROTEIN LINKAGE MAP BY TWO-HYBRID SYSTEMSirpa Aho; Fiscal Year: 2002..abstract_text> ..
- ROLE OF PRE FIBRILLAR AMYLOID IN ALZHEIMER'S DISEASEDean Hartley; Fiscal Year: 2002....
- Effects of antipsychotic drugs on brain and behaviorFRANK TARAZI; Fiscal Year: 2005..adult rats, and should evolve new principles for improved treatments for childhood-onset schizophrenia and other major pediatric psychiatric disorders. ..
- MECHANISMS OF LEUKOCYTE RECRUITMENT IN IBDCiaran Kelly; Fiscal Year: 2005..An in-depth, mechanistic understanding of the regulation of ENA-78 gene expression in human enterocytes may lead to novel therapeutic approaches to IBD. ..
- Nitrosourea-induced growth arrest and apoptotic pathwaysKevin Brown; Fiscal Year: 2007..Understanding the molecules, mechanisms and pathways that control cellular response to MNNG and other genotoxins is important in preventing cancer and improving our ability to design effective cancer therapeutics. ..
- The 10th Symposium of the International Diabetes Epidemiology GroupMarian Rewers; Fiscal Year: 2006..unreadable] [unreadable]..
- GREEN TEA POLYPHENOL CHEMOPREVENTION IN KERATINOCYTESRICHARD ECKERT; Fiscal Year: 2006..The central goal of this proposal is to gain new information regarding the mechanism of EGCG action. It is hoped that these studies lead to the design of new strategies for enhancing the effectiveness of these agents. ..
- OXIDANT/ANTIOXIDANT EFFECTS OF TGF BETA1 ON LUNG CELLSBARRY FANBURG; Fiscal Year: 2001..We anticipate that the composite studies will help to establish cellular redox status as an important intermediary in the actions of TGFbeta1 that may contribute to remodeling of the lung in disease states. ..
- Neural Patterns of Visual Learning in SchizophreniaNicola Cascella; Fiscal Year: 2006..Enduring primary negative symptoms are also expected to prevent feedback-dependent changes in the cingulate cortex. [unreadable] [unreadable]..
- Localization of a type 1 diabetes susceptibility geneELIZABETH ELLER; Fiscal Year: 2006..This work could also provide an example for identifying susceptibility genes for other complex diseases. ..
- Beta-Amyloid Protofibrils Cause AD Neuronal DysfunctionDean Hartley; Fiscal Year: 2006..abstract_text> ..
- Integrin-Transglutaminase Associated and Cell AdhesionALEXEY BELKIN; Fiscal Year: 2006..Ultimately, this acquired knowledge will advance our understanding of basic mechanisms of cell-matrix interactions. ..
- THE CRES GENE IN REPRODUCTIONGail Cornwall; Fiscal Year: 2005..abstract_text> ..
- REGULATION OF HYPOTHALAMIC SIGNALING BY RGS4 PROTEINNANCY MUMA; Fiscal Year: 2001....