Genomes and Genes
choline o acetyltransferase
Summary: An enzyme that catalyzes the formation of acetylcholine from acetyl-CoA and choline. EC 126.96.36.199.
Publications193 found, 100 shown here
- Cholinergic basal forebrain neurons burst with theta during waking and paradoxical sleepMaan Gee Lee
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
J Neurosci 25:4365-9. 2005..Through their maximal firing and rhythmic theta discharge during active waking and paradoxical sleep, the cholinergic neurons can thus modulate the cortex to promote activation along with plasticity during these two states...
- Acetylcholine synthesis by choline acetyltransferase of a peripheral type as demonstrated in adult rat dorsal root ganglionJean Pierre Bellier
Molecular Neuroscience Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan
J Neurochem 101:1607-18. 2007..Thus pChAT provides a new window on the role of neuronal acetylcholine...
- The biological role of non-neuronal acetylcholine in plants and humansI Wessler
Department of Pharmacology, University of Mainz, Germany
Jpn J Pharmacol 85:2-10. 2001....
- Parvalbumin, calbindin, or calretinin in cortically projecting and GABAergic, cholinergic, or glutamatergic basal forebrain neurons of the ratIvana Gritti
Dipartimento di Scienze Cliniche L Sacco, Universita degli Studi di Milano, 20157 Milan, Italy
J Comp Neurol 458:11-31. 2003....
- Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinomaPingfang Song
Department of Pathology, Oregon Health and Science University, Portland, Oregon 97239, USA
Cancer Res 63:214-21. 2003..These findings demonstrate that SCLC can synthesize, secrete, and degrade ACh and that released ACh stimulates SCLC cell growth. Identification of this new autocrine loop provides a potential new target for therapeutic intervention...
- Regulation of the cholinergic gene locus by the repressor element-1 silencing transcription factor/neuron restrictive silencer factor (REST/NRSF)Masahito Shimojo
Department of Molecular and Cellular Biochemistry, University of Kentucky, Chandler Medical Center, Lexington, KY 40536 0298, USA
Life Sci 74:2213-25. 2004..Protein kinase A regulation of the cholinergic gene locus in PC 12 cells can thus be attributed, at least in part, to increased synthesis of REST4, which in turn derepresses the repressor activity of REST/NRSF...
- Gene expression of mouse choline acetyltransferase. Alternative splicing and identification of a highly active promoter regionH Misawa
Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Japan
J Biol Chem 267:20392-9. 1992..Possible mechanisms that would explain this observation are discussed...
- Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholineM M Mesulam
Cognitive Neurology and Alzheimer s Disease Center, Department of Neurology, Northwestern University, Chicago, IL 60611, USA
Neuroscience 110:627-39. 2002..The inhibition of butyrylcholinesterase may therefore provide a desirable feature of cholinergic therapies, including those aimed at treating Alzheimer's disease...
- Evidence for glutamate, in addition to acetylcholine and GABA, neurotransmitter synthesis in basal forebrain neurons projecting to the entorhinal cortexI D Manns
Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, 3801 University Street, Montreal, QC, Canada H3A 2B4
Neuroscience 107:249-63. 2001..Accordingly, as either co-transmitter or primary transmitter within basalocortical afferents, glutamate could have the capacity to modulate the entorhinal cortex and promote its role in memory...
- BAC transgenic mice express enhanced green fluorescent protein in central and peripheral cholinergic neuronsYvonne N Tallini
Biomedical Science Department, College of Veterinary Medicine, Ithaca, New York, USA
Physiol Genomics 27:391-7. 2006..Moreover, this genetic strategy allows the selective expression and conditional inactivation of genes of interest in cholinergic nerves of the central nervous system and peripheral nervous system...
- Functional identification of a vesicular acetylcholine transporter and its expression from a "cholinergic" gene locusJ D Erickson
Section on Molecular Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892
J Biol Chem 269:21929-32. 1994....
- Innervation of rat iris by trigeminal and ciliary neurons expressing pChAT, a novel splice variant of choline acetyltransferaseOsamu Yasuhara
Molecular Neuroscience Research Center, Shiga University of Medical Science, Otsu 520 2192, Japan
J Comp Neurol 472:232-45. 2004..Here, we provide evidence that iridial pChAT nerves are composed of postganglionic parasympathetic efferents from the ciliary ganglion and, more interestingly, somatic sensory afferents of the trigeminal ophthalmic nerve...
- Molecular characterization of the family of choline transporter-like proteins and their splice variantsE Traiffort
Institut de Neurobiologie Alfred Fessard IFR 2118 CNRS, Laboratoire de Neurobiologie Cellulaire et Moleculaire, UPR 9040, Gif sur Yvette, France
J Neurochem 92:1116-25. 2005..These findings suggest specific roles for CTL1 splice variants in both neuronal and oligodendrocyte physiology...
- A protein encoded by an alternative splice variant of choline acetyltransferase mRNA is localized preferentially in peripheral nerve cells and fibersI Tooyama
Neuroanatomny Unit, Molecular Neuroscience Research Center, Shiga University of Medical Science, Otsu, Japan
J Chem Neuroanat 17:217-26. 2000....
- The non-neuronal cholinergic system in humans: expression, function and pathophysiologyIgnaz Wessler
Institute of Pharmacology, University of Mainz, Obere Zahlbacher Str 67, D 55101 Mainz, Germany
Life Sci 72:2055-61. 2003..In conclusion, it is time to revise the role of acetylcholine in humans. Its biological and pathobiological roles have to be elucidated in more detail and possibly, new therapeutical targets may become available...
- Modulation of cholinergic systems by manganeseYoram Finkelstein
Unit and Service of Neurology and Toxicology, Shaare Zedek Medical Center, Jerusalem, Israel
Neurotoxicology 28:1003-14. 2007..These observations highlight the importance of studying the role of the CNS cholinergic systems in manganese-mediated neurotoxicity...
- Morphological characterization of electrophysiologically and immunohistochemically identified basal forebrain cholinergic and neuropeptide Y-containing neuronsAlvaro Duque
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
Brain Struct Funct 212:55-73. 2007..The presence of local axon collaterals in both cholinergic and NPY neurons indicates that the BF is not a mere conduit for various brainstem inputs to the cortex, but a site where substantial local processing must take place...
- Kinesin-II is required for axonal transport of choline acetyltransferase in DrosophilaK Ray
Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0683, USA
J Cell Biol 147:507-18. 1999..Furthermore, the data lead to the conclusion that the cargo transport requirements of different classes of neurons may lead to upregulation of specific pathways of axonal transport...
- Low voltage-activated calcium and fast tetrodotoxin-resistant sodium currents define subtypes of cholinergic and noncholinergic neurons in rat basal forebrainSun Ho Han
Department of Medical Pharmacology and Toxicology, College of Medicine, Texas A and M University System Health Science Center, 1114 TAMU, College Station, TX 77843 1114, USA
Brain Res Mol Brain Res 134:226-38. 2005..These results suggest novel features of subtypes of cholinergic and noncholinergic neurons within the BF that may provide new insights for understanding normal BF function...
- Urocortin 1-containing neurons in the human Edinger-Westphal nucleusA E Ryabinin
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, 97239, USA
Neuroscience 134:1317-23. 2005....
- Urocortin 1 distribution in mouse brain is strain-dependentA Z Weitemier
Department of Behavioral Neuroscience, Orego Health and Science University, Portland, OR 97239, USA
Neuroscience 132:729-40. 2005..We show that the urocortin 1-positive neurons of this brain area form a separate population of cells that we propose to be called the non-preganglionic Edinger-Westphal nucleus...
- Inhibitors of nitric oxide synthase attenuate nerve growth factor-mediated increases in choline acetyltransferase expression in PC12 cellsBettina E Kalisch
Department of Physiology, University of Western Ontario, and The John P Robarts Research Institute, London, Ontario, Canada
J Neurochem 81:624-35. 2002..The present study indicates that NO may be involved in the modulation of signal transduction pathways by which NGF leads to increased ChAT gene expression in PC12 cells...
- Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cellsBecky J Proskocil
Division of Neuroscience, Oregon National Primate Research Center, 505 Northwest 185th Avenue, Beaverton, Oregon 97006, USA
Endocrinology 145:2498-506. 2004..This pathway may also explain some of the effects of nicotine on fetal development and also provides additional mechanisms by which smoking affects lung cancer growth and development...
- Down-regulation of the non-neuronal acetylcholine synthesis and release machinery in acute allergic airway inflammation of rat and mouseKatrin S Lips
Institute for Anatomy and Cell Biology, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
Life Sci 80:2263-9. 2007....
- Regulation of choline acetyltransferase/lacZ fusion gene expression in putative cholinergic neurons of Drosophila melanogasterT Kitamoto
Division of Neurosciences, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
J Neurobiol 28:70-81. 1995..With these constructs, however, strong ectopic expression was also observed in several non-neuronal tissues...
- Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9I Lopez-Coviella
Department of Psychiatry and Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Science 289:313-6. 2000..Although certain other BMPs also up-regulated the cholinergic phenotype in vitro, they were less effective than BMP-9. These data indicate that BMP-9 is a differentiating factor for cholinergic central nervous system neurons...
- Localization of choline acetyltransferase-expressing neurons in the larval visual system of Drosophila melanogasterK Yasuyama
Division of Neurosciences, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
Cell Tissue Res 282:193-202. 1995..Our observations indicate that acetylcholine may be a neurotransmitter in the larval photoreceptor cells as well as in a first-order interneuron in the larval visual system of Drosophila melanogaster...
- Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthoodDan Qiao
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Environ Health Perspect 111:536-44. 2003..The present findings indicate a wide window of vulnerability of cholinergic systems to CPF, extending from prenatal through postnatal periods, occurring independently of adverse effects on general cellular neurotoxicity...
- Increased acetylcholine levels in skin biopsies of patients with atopic dermatitisIgnaz Wessler
Institute of Pharmacology, University of Mainz, Obere Zahlbacher Str 67, D 55101 Mainz, Germany
Life Sci 72:2169-72. 2003..The present study demonstrates the widespread expression of ChAT protein in the vast majority of human skin cells. Tissue levels of acetylcholine are greatly (14-fold) enhanced in the superficial 2 mm skin of AD patients...
- Aberrant patterning of neuromuscular synapses in choline acetyltransferase-deficient miceEugene P Brandon
Laboratory of Genetics and Peptide Biology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Neurosci 23:539-49. 2003..These results indicate that ChAT is uniquely essential for the patterning and formation of mammalian neuromuscular synapses...
- Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthoodDan Qiao
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813 DUMC Rm c162, LSRC Building Research Drive, Durham, NC 27710, USA
Brain Res Dev Brain Res 148:43-52. 2004....
- Mice lacking specific nicotinic acetylcholine receptor subunits exhibit dramatically altered spontaneous activity patterns and reveal a limited role for retinal waves in forming ON and OFF circuits in the inner retinaA Bansal
Synapse Formation and Function Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Howard Hughes Medical Institute National Institutes of Health Research Scholars Program, Bethesda, Maryland, USA
J Neurosci 20:7672-81. 2000..These results indicate that retinal waves mediated by nAChRs are involved in, but not required for, the development of neural circuits that define the ON and OFF sublamina of the inner plexiform layer...
- Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickelTheodore A Slotkin
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Environ Health Perspect 115:93-101. 2007..In light of the large number of chemicals that are potential developmental neurotoxicants, there is a need to develop rapid screening techniques...
- Expression of muscarinic receptor types in the primate ovary and evidence for nonneuronal acetylcholine synthesisS Fritz
Anatomisches Institut, Technische Universitat Munchen, D 80802 München, Germany
J Clin Endocrinol Metab 86:349-54. 2001..We propose that ACh may serve as an as yet unrecognized factor involved in the complex regulation of ovarian function in the primate, e.g. regulation of cell proliferation or progesterone production...
- Changes in cholinergic function in the frontal cortex and hippocampus of rat exposed to ethanol and acetaldehydeM Jamal
Department of Forensic Medicine, Faculty of Medicine, Kagawa University, 1750 1, Ikenobe, Miki, Kita, Kagawa 761 0793, Japan
Neuroscience 144:232-8. 2007....
- Dysfunction of the non-neuronal cholinergic system in the airways and blood cells of patients with cystic fibrosisIgnaz Wessler
Institute of Pathology, Univ Hospital, Johannes Gutenberg University Mainz, Langenbeckstr 1, D 55101 Mainz, Germany
Life Sci 80:2253-8. 2007....
- Administration of keratinocyte growth factor down-regulates the pulmonary capacity of acetylcholine productionVeronika Grau
Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, University of Giessen Lung Center, Justus Liebig University Giessen, Rudolf Buchheim Str 7, D 35385 Giessen, Germany
Int J Biochem Cell Biol 39:1955-63. 2007....
- Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cellsRuth R Jameson
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Environ Health Perspect 114:667-72. 2006....
- The place of choline acetyltransferase activity measurement in the "cholinergic hypothesis" of neurodegenerative diseasesAntonio Contestabile
Department of Biology, University of Bologna, Via Selmi 3, Bologna 40126, Italy
Neurochem Res 33:318-27. 2008....
- Perioculomotor cell groups in monkey and man defined by their histochemical and functional properties: reappraisal of the Edinger-Westphal nucleusAnja K Horn
Institute of Anatomy, Ludwig Maximilian University of Munich, D 80336 Munich, Germany
J Comp Neurol 507:1317-35. 2008..The present results form the basis for addressing the appropriate functional cell groups in correlative clinicopathological studies...
- Discharge profiles of identified GABAergic in comparison to cholinergic and putative glutamatergic basal forebrain neurons across the sleep-wake cycleOum Kaltoum Hassani
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Quebec, Canada
J Neurosci 29:11828-40. 2009..GABAergic neurons would thus play similar or reciprocal roles to other cholinergic and glutamatergic BF neurons in regulating cortical activity and muscle tone along with behavior across sleep-wake states...
- BDNF and CNTF regulate cholinergic properties of sympathetic neurons through independent mechanismsJohn D Slonimsky
Department of Biology, Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
Mol Cell Neurosci 23:648-60. 2003..The results of this study indicate that BDNF and CNTF, acting through independent pathways, modulate NE and ACh cotransmission to regulate the level of sympathetic excitation or inhibition of cardiac myocytes...
- M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretionPingfang Song
Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
Cancer Res 67:3936-44. 2007..These findings suggest that M3R antagonists may be useful adjuvants for treatment of SCLC and, potentially, other cancers...
- Adenoviral gene transfer of hepatocyte growth factor prevents death of injured adult motoneurons after peripheral nerve avulsionYuichi Hayashi
Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, 2 6 Musashidai, Fuchu, Tokyo 183 8526, Japan
Brain Res 1111:187-95. 2006..These results indicate that HGF may prevent the degeneration of motoneurons in adult humans with motoneuron injury and motor neuron diseases...
- Labeled lines in the retinotectal system: markers for retinorecipient sublaminae and the retinal ganglion cell subsets that innervate themMasahito Yamagata
Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, MO 63110, USA
Mol Cell Neurosci 33:296-310. 2006..Our results define laminar-specified circuits from retina to brain and support a model in which RGCs transmit information from multiple sources to single central laminae, where it can be integrated...
- Gabaergic neurons with alpha2-adrenergic receptors in basal forebrain and preoptic area express c-Fos during sleepM Modirrousta
Montreal Neurological Institute, McGill University, 3801 University Street, Room 897, Montreal, Quebec, Canada H3A 2B4
Neuroscience 129:803-10. 2004....
- Effects of repeated oral postnatal exposure to chlorpyrifos on cholinergic neurochemistry in developing ratsJason R Richardson
Center for Environmental Health Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi 39762, USA
Toxicol Sci 84:352-9. 2005..In addition, the long-term reduction of brain ChE activity observed following repeated postnatal exposure to CPS is attributable to permanent inactivation or "aging" of the enzyme...
- Ovarian acetylcholine and muscarinic receptors: hints of a novel intrinsic ovarian regulatory systemArtur Mayerhofer
Anatomisches Institut der Universität München, D 80802 München, Germany
Microsc Res Tech 59:503-8. 2002..Thus, our results outline first details of an unexpected intraovarian, non-neuronal cholinergic system, and suggest that it may be involved in the regulation of cell proliferation in the ovary...
- Expression of lynx1 in developing lung and its modulation by prenatal nicotine exposureHarmanjatinder S Sekhon
Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 97006, USA
Cell Tissue Res 320:287-97. 2005..Thus, lynx1 is co-expressed with nAChR in the lung. Alteration of lynx1 levels is a potential new mechanism by which nicotine affects lung development...
- Partial cloning and expression of mRNA coding choline acetyltransferase in the spinal cord of the goldfish, Carassius auratusSoon Ju Moon
Laboratory of Fish Physiology, Graduate School of Biosphere Sciences, Hiroshima University, Higashi Hiroshima 739 8528, Japan
Comp Biochem Physiol B Biochem Mol Biol 141:253-60. 2005..In the cord, putative presynaptic sympathetic neurons were also labeled...
- Expression of the cholinergic gene locus in the rat placentaUwe Pfeil
Institute for Anatomy and Cell Biology, Justus Liebig University, Aulweg 123, 35385 Giessen, Germany
Histochem Cell Biol 122:121-30. 2004..While ChAT is nearly ubiquitously expressed in rat placenta, VAChT immunoreactivity is localised cell type specifically, implying that both vesicular and non-vesicular ACh release machineries prevail in placental cell types...
- A novel untranslated 'exon H' of the human choline acetyltransferase gene in placentaI Robert
Laboratoire de Genetique Moleculaire des Eucaryotes, CNRS, Biologie Moléculaire et de Génie Génétique, INSERM, Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France
J Neurochem 79:9-16. 2001..These data may be possibly explained by the presence of a placenta specific promoter in the ChAT gene, which might be the proximal promoter P1...
- Choline acetyltransferase mutations cause myasthenic syndrome associated with episodic apnea in humansK Ohno
Department of Neurology and Neuromuscular Research Laboratory, Mayo Clinic, Rochester, MN 55905, USA
Proc Natl Acad Sci U S A 98:2017-22. 2001....
- Acetylcholine synthesis and quantal release reconstituted by transfection of mediatophore and choline acetyltranferase cDNAsA Bloc
Pharmacologie, Centre Medical Universitaire, Geneve, Switzerland
Eur J Neurosci 11:1523-34. 1999....
- Hippocampal brain-derived neurotrophic factor gene regulation by exercise and the medial septumNicole C Berchtold
Institute for Brain Aging and Dementia, University of California, Irvine, California, 92697 4540, USA
J Neurosci Res 68:511-21. 2002..These results are discussed in relation to their implications for aging and Alzheimer's disease...
- Kinesin-2 differentially regulates the anterograde axonal transports of acetylcholinesterase and choline acetyltransferase in DrosophilaRehan Baqri
Tata Institute of Fundamental Research, Mumbai 400 005, India
J Neurobiol 66:378-92. 2006..Altogether, these suggest that kinesin-2 independently transports AChE and ChAT within the same axon. It also implies that cargo availability could regulate the rate and frequency of transports by kinesin motors...
- Acetylcholine and choline dynamics provide early and late markers of traumatic brain injuryOscar U Scremin
Veterans Affairs Greater Los Angeles Healthcare System, Research Service, Los Angeles, CA 90073, USA
Brain Res 1124:155-66. 2006..Choline acetyltransferase activity was reduced in the impact center region but not affected in the adjacent and contralateral regions or by craniotomy...
- Selective immunolesions of cholinergic neurons in mice: effects on neuroanatomy, neurochemistry, and behaviorJ Berger-Sweeney
Department of Biological Sciences, Wellesley College, Wellesley, Massachusetts 02481, USA
J Neurosci 21:8164-73. 2001....
- Stimuli that induce a cholinergic neuronal phenotype of NG108-15 cells upregulate ChAT and VAChT mRNAs but fail to increase VAChT proteinV Dolezal
Institute of Physiology, CAS, Prague, Czech Republic
Brain Res Bull 54:363-73. 2001....
- Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposureT A Slotkin
Department of Pharmacology and Cancer Biology, Box 3813 DUMC, Duke University Medical Center, 27710, Durham, NC, USA
Brain Res 902:229-43. 2001..The effects are likely to contribute to gender-selective alterations in behavioral performance that persist or emerge long after the termination of exposure and well after the restoration of cholinesterase activity...
- Effects of sex hormones, forskolin, and nicotine on choline acetyltransferase activity in human isolated placentaIgnaz Wessler
Department of Pharmacology, Universitat Mainz, Obere Zahlbacher Strasse 67, 55101 Mainz, Germany
Neurochem Res 28:489-92. 2003..The risks of maternal smoking during pregnancy cannot be attributed to an effect of nicotine on placental ChAT activity. Differences in the regulation of ChAT appear to exist between neuronal and nonneuronal cells...
- Protective effects of betaxolol in eyes with kainic acid-induced neuronal deathEun Woo Cheon
Division of Food Science, Jinju International University, 270 San Sangmun ri Munsan eup, Jinju, Kyungnam 660 759, South Korea
Brain Res 1069:75-85. 2006..The present study suggests that topically applied betaxolol has neuroprotective effect on the retinal cell damage due to KA-induced neurotoxicity...
- Re-growth of catecholaminergic fibers and protection of cholinergic spinal cord neurons in spinal repaired ratsYu Shang Lee
Department of Anatomy and Neurobiology, University of California, Irvine, USA
Eur J Neurosci 23:693-702. 2006....
- Improved detection of fluorogold-labeled neurons in long-term studiesMahnaz Akhavan
Department of Neurology, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
J Neurosci Methods 152:156-62. 2006..We conclude that FG-labeling is a useful tool to determine neuronal counts in long-term studies, but should be used cautiously for neuronal size measurements...
- Selective cholinergic lesions in the rat nucleus basalis magnocellularis with limited damage in the medial septum specifically alter attention performance in the five-choice serial reaction time taskH Harati
Laboratoire d Imagerie et de Neurosciences Cognitives UMR 7191, Universite Louis Pasteur, CNRS, Institut Fédérératif de Recherche 37 de Neurosciences, GDR 2905 du CNRS, 12 rue Goethe, F 67000 Strasbourg, France
Neuroscience 153:72-83. 2008..Discrepancies with previously reported results are discussed in terms of differences in lesion extent/specificity and training levels...
- Cholinergic modulation of vibrissal receptive fields in trigeminal nucleiElena Timofeeva
Centre de Recherche Universite Laval Robert Giffard, Quebec City, Quebec, G1J 2G3, Canada
J Neurosci 25:9135-43. 2005....
- Characterization of medial septal glutamatergic neurons and their projection to the hippocampusLuis V Colom
Department of Biological Sciences, University of Texas at Brownsville Texas Southmost College, Brownsville, Texas
Synapse 58:151-64. 2005..Thus, the septo-hippocampal projection needs to be reconsidered as a three neurotransmitter pathway...
- Extensive immunolesions of basal forebrain cholinergic system impair offspring recognition in sheepG Ferreira
Laboratoire de Comportement Animal, Station PRC, , 37380 Nouzilly, France
Neuroscience 106:103-16. 2001..However, since only extensive lesions affect performance, this indicates that the basal forebrain cholinergic system possesses substantial reserve capacity to sustain cognitive functions...
- GABAB and CB1 cannabinoid receptor expression identifies two types of septal cholinergic neuronsGábor Nyiri
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, 1083, Szigony u 43, Hungary
Eur J Neurosci 21:3034-42. 2005..The results also suggest that cholinergic transmission in the hippocampus is fine-tuned by endocannabinoid signalling...
- Cholinergic and noncholinergic brainstem neurons expressing Fos after paradoxical (REM) sleep deprivation and recoveryLaure Verret
CNRS UMR 5167, Institut Fédératif des Neurosciences de Lyon IFR 19, Faculté de médecine RTH Laennec, 7, Rue Guillaume Paradin, 69372 Lyon Cedex 08, France
Eur J Neurosci 21:2488-504. 2005..Altogether, our results open a new avenue of research to identify the specific role of the populations of neurons revealed, their interrelations and their neurochemical identity...
- Expression of high affinity choline transporter during mouse development in vivo and its upregulation by NGF and BMP-4 in vitroBrygida Berse
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 715 Albany Street, Room L 808C, Boston, MA 02118, USA
Brain Res Dev Brain Res 157:132-40. 2005..The effect of NGF was dependent on the PI3K signaling, as it was abolished by the PI3K inhibitor LY294002. This result indicates that some of the signals regulating other cholinergic-specific genes also control CHT expression...
- Endogenous nicotinic cholinergic activity regulates dopamine release in the striatumF M Zhou
Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030-3498, USA
Nat Neurosci 4:1224-9. 2001..The results offer new perspectives when considering nicotine addiction and the high prevalence of smoking in schizophrenics...
- Effect of N-methyl-d-aspartate receptor blockade on plasticity of frontal cortex after cholinergic deafferentation in ratJ E Garrett
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
Neuroscience 140:57-66. 2006..Thus, N-methyl-d-aspartate receptor blockade prevented both GluR1 and spine density upregulation following cholinergic deafferentation, suggesting that these effects are N-methyl-d-aspartate receptor-mediated...
- Effects of hypocretin-saporin injections into the medial septum on sleep and hippocampal thetaD Gerashchenko
West Roxbury VA Medical Center and Harvard Medical School, 1400 VFW Parkway, West Roxbury, MA 02132, USA
Brain Res 913:106-15. 2001..In this way, hypocretin, which is implicated in feeding, energy metabolism and wakefulness, serves to influence cognitive processes critical for the animal's survival...
- Knockdown of the L3/Lhx8 gene suppresses cholinergic differentiation of murine embryonic stem cell-derived spheresTakayuki Manabe
Department of 2nd Anatomy, Faculty of Medicine, Nara Medical University, 840 Shijyo cho, Kasihara City, Nara 634 8521, Japan
Int J Dev Neurosci 26:249-52. 2008..These results strongly suggest that L3/Lhx8 is a key factor for cholinergic differentiation of murine ES cell-derived spheres and is involved in basal forebrain development...
- Origins of spinal cholinergic pathways in amphibians demonstrated by retrograde transport and choline acetyltransferase immunohistochemistryJesus M Lopez
Department of Cell Biology, Faculty of Biology, University Complutense, 28040 Madrid, Spain
Neurosci Lett 425:73-7. 2007....
- Antidepressant effects of Soyo-san on Immobilization stress in ovariectomized female ratsJin Kyung Oh
Department of Oriental Medical Science, Graduate School of East West Medical Science, Kyung Hee University, 1 Seochon ri, Kiheung eup, Youngin shi, Kyungji do 449 701, South Korea
Biol Pharm Bull 30:1422-6. 2007..05, respectively). The serum level of corticosterone in the SOY group was significantly lower than that in the control group (p<0.05). These results suggest that Soyo-san might prove to be an effective antidepressant agent...
- Identification and kainic acid-induced up-regulation of low-affinity p75 neurotrophin receptor (p75NTR) in the nigral dopamine neurons of adult ratsYan Qin Wang
Institute of Neurosciences, The Fourth Military Medical University, 17 Changle West Road, Xi an 710032, PR China
Neurochem Int 53:56-62. 2008....
- Human and monkey cholinergic neurons visualized in paraffin-embedded tissues by immunoreactivity for VAChT, the vesicular acetylcholine transporterM K Schafer
Department of Anatomy and Cell Biology, Philipps University, Marburg, FRG
J Mol Neurosci 6:225-35. 1995..VAChT-positive cell bodies, presumably corresponding to cholinergic sympathetic sudomotor neurons, were a significant fraction of the total principal cell population in monkey and human thoracic sympathetic ganglia...
- Rescue of rat anterior horn neurons after spinal cord injury by retrograde transfection of adenovirus vector carrying brain-derived neurotrophic factor geneHideaki Nakajima
Division of Orthopaedics and Rehabilitation Medicine, Department of Surgery, University of Fukui Faculty of Medical Sciences, Fukui, Japan
J Neurotrauma 24:703-12. 2007..Our results suggest that in vivo targeted retrograde AdV-BDNF-gene delivery may enhance neuronal survival following traumatic injury of the spinal cord...
- Hypothalamic proopiomelanocortin (POMC) neurons have a cholinergic phenotypeBjörn Meister
Department of Neuroscience, The Retzius Laboratory, Karolinska Institutet, SE 17177 Stockholm, Sweden
Eur J Neurosci 24:2731-40. 2006..The results indicate a role for ACh in control of energy balance, mediating the effects of peripheral hormones such as leptin and insulin...
- Stereological estimates of the basal forebrain cell population in the rat, including neurons containing choline acetyltransferase, glutamic acid decarboxylase or phosphate-activated glutaminase and colocalizing vesicular glutamate transportersI Gritti
Dipartimento di Scienze Cliniche Luigi Sacco, Universita degli Studi di Milano, Via Giovan Battista Grassi 74, Milan, Italy 20157
Neuroscience 143:1051-64. 2006....
- Nerve growth factor and glial cell line-derived neurotrophic factor restore the cholinergic neuronal phenotype in organotypic brain slices of the basal nucleus of MeynertC Weis
Department of Psychiatry, University Hospital Innsbruck, Anichstr. 35, A-6020, Innsbruck, Austria
Neuroscience 102:129-38. 2001..In conclusion, it is shown that, in the axotomized organotypic slice model, the number of cholinergic neurons is decreased, but can be partly restored by nerve growth factor and glial cell line-derived neurotrophic factor...
- Role of cholinergic mossy fibers in medial vestibular and prepositus hypoglossal nuclei in vestibular compensationM Fukushima
Department of Otolaryngology, Osaka University Medical School, 2-2 Yamadaoka, Suita, 565-0871, Japan
Neuroscience 102:159-66. 2001....
- Effects of neonatal handling on the basal forebrain cholinergic system of adult male and female ratsS Pondiki
Laboratory of Biology Biochemistry, Faculty of Nursing, School of Health Sciences, University of Athens, Athens, Greece
Neuroscience 142:305-14. 2006....
- Aging causes partial loss of basal forebrain but no loss of pontine reticular cholinergic neuronsKaren A Baskerville
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA
Neuroreport 17:1819-23. 2006..This selective loss of cholinergic neurons may, in part, account for the cognitive deficits observed in aging and, considering previous findings in this model, may be related to oxidative stress...
- Distinct subpopulations of cyclic guanosine monophosphate (cGMP) and neuronal nitric oxide synthase (nNOS) containing sympathetic preganglionic neurons in spontaneously hypertensive and Wistar-Kyoto ratsKellysan Powers-Martin
Division of Health Sciences, Murdoch University, Perth 6150, WA, Australia
J Comp Neurol 497:566-74. 2006..These results suggest that cGMP is a key signaling molecule in SPN, and that a reduced number of NOS neurons in the SHR may play a role in the increase in sympathetic tone associated with hypertension in these animals...
- The cholinergic innervation develops early and rapidly in the rat cerebral cortex: a quantitative immunocytochemical studyN Mechawar
, and Centre de Recherche en Sciences Neurologiques, , , P.O. Box 6128, Succursale Centre-Ville, H3C 3J7, Montreal, QC, Canada
Neuroscience 108:555-67. 2001....
- Postnatal development of the cholinergic innervation in the dorsal hippocampus of rat: Quantitative light and electron microscopic immunocytochemical studyNicolas Aznavour
Departement de pathologie et biologie cellulaire, Centre de Recherche en Sciences Neurologiques, Faculte de Medecine, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
J Comp Neurol 486:61-75. 2005..They emphasize the remarkable growth capacities of individual ACh neurons and substantiate a role for diffuse transmission by ACh during hippocampal development...
- Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathwayMaria Grazia Giovannini
Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Neurobiol Dis 11:257-74. 2002..We show here for the first time in vivo the pivotal role played by the p38MAPK microglial signal transduction pathway in the inflammatory response to the Abeta(1-42) deposit...
- Does the release of acetylcholine in septal slices originate from intrinsic cholinergic neurons bearing p75(NTR) receptors? A study using 192 IgG-saporin lesions in ratsA Birthelmer
Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Universität Freiburg, Neuropharmakologisches Labor, Hansastrasse 9A, D 79104 Freiburg, Germany
Neuroscience 122:1059-71. 2003..These data also suggest that the MS and the DBB may be the target of extrinsic cholinergic innervation that does not bear p75(NTR) receptors...
- Age-dependent changes in axonal transport and cellular distribution of Tau 1 in the rat basal forebrain neuronsGrazyna Niewiadomska
Department of Neurophysiology, Nencki Institute, 3 Pasteur St, 02 093 Warsaw, Poland
Neuroreport 14:1701-6. 2003..The findings demonstrate that in aged rats reduced retrograde labeling of BF neurons coincide with lower expression of cholinergic markers and is accompanied by altered cellular distribution of Tau 1...
- Basal forebrain cholinergic system is involved in rapid nerve growth factor (NGF)-induced plasticity in the barrel cortex of adult ratsNeal Prakash
Departments of Neurobiology and Behavior, University of California, Irvine, California 92697 4550, USA
J Neurophysiol 91:424-37. 2004....
- Localization of dopamine D2 receptors on cholinergic interneurons of the dorsal striatum and nucleus accumbens of the ratAdriana A Alcantara
Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA
Brain Res 986:22-9. 2003....
- Evidence that toxicity of lipopolysaccharide upon cholinergic basal forebrain neurons requires the presence of glial cells in vitroCarla Weis
Laboratory of Psychiatry, Department of Psychiatry, University Hospital Innsbruck, A 6020 Innsbruck, Austria
Brain Res Bull 58:91-8. 2002..Our results suggest that lipopolysaccharide-induced degeneration of both microtubule-associated protein-2-like immunoreactive as well as specific killing of cholinergic forebrain neurons in vitro are mediated by glial cells...
- Nerve growth factor prevents cell death and induces hypertrophy of basal forebrain cholinergic neurons in rats withdrawn from prolonged ethanol intakeA Cadete-Leite
Department of Anatomy, Porto Medical School, Alameda Prof Hernani Monteiro, 4200 319, Porto, Portugal
Neuroscience 119:1055-69. 2003....
- Tumor necrosis factor-alpha triggers cell death of sensitized potassium chloride-stimulated cholinergic neuronsBirgit Zassler
Laboratory of Psychiatry, Department of Psychiatry, University Hospital Innsbruck, Anichstr 35, Austria
Brain Res Mol Brain Res 113:78-85. 2003..Cortical overactivation combined with an increased expression of pro-inflammatory cytokines may contribute to the cell death observed in Alzheimer's disease and ageing...
- Immunohistochemical characterisation of cholinergic neurons in the anterior pelvic ganglion of the male pigJerzy Kaleczyc
Department of Animal Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury, Olsztyn Kortowo II, Poland
Folia Histochem Cytobiol 41:65-72. 2003....
- Rivastigmine antagonizes deficits in prepulse inhibition induced by selective immunolesioning of cholinergic neurons in nucleus basalis magnocellularisM Ballmaier
Division of Pharmacology, Department of Biomedical Sciences and Biotechnologies, Brescia University Medical School, Via Valsabbina 19, 25123 Brescia, Italy
Neuroscience 114:91-8. 2002....
- Expression of a splice variant of choline acetyltransferase in magnocellular neurons of the tuberomammillary nucleus of ratH Kanayama
Molecular Neuroscience Research Center, Shiga University of Medical Science, Seta tsukinowa cho, Otsu, 520 2192, Shiga, Japan
Neuroscience 118:243-51. 2003..The results raise the possibility that some of the known diverse projection areas of this nucleus may have a cholinergic component...
- Long-term plastic changes in galanin innervation in the rat basal forebrainI Hartonian
Department of Biological Sciences, California State University, 5151 State University Drive, Los Angeles, CA 90032, USA
Neuroscience 115:787-95. 2002..Our model can be useful to test the role that galanin plays in the regulation of acetylcholine and the efficacy of galanin inhibitors as potential therapeutic interventions in Alzheimer's disease...
- ACETYL COA SYNTHETASE AND ACETATE UPTAKEPaul Carroll; Fiscal Year: 1999....
- MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITYTheodore Slotkin; Fiscal Year: 2004..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
- Fetal & Adolescent Nicotine Effects on CNS 5HT SystemsTheodore Slotkin; Fiscal Year: 2003..abstract_text> ..
- DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEMTheodore Slotkin; Fiscal Year: 2003....
- TRAINING IN AGE-RELATED NEURODEGENERATIVE DISEASESElliott Mufson; Fiscal Year: 2008..Finally the program will provide a broad-base of knowledge on neurodegenerative disorders as well as other instruction important for enhancing the interpersonal and professional skills of our trainees. ..
- Estrogenic-cholinergic interactions in memory modulationKARYN FRICK; Fiscal Year: 2004..abstract_text> ..
- Hormone and enrichment effects on memory in aging miceKARYN FRICK; Fiscal Year: 2009..Elucidation of these issues may ultimately lead to the development of safer and more effective treatments to prevent cognitive decline and dementia in women ..
- "Nicotine: Potential therapies and possible pitfalls"Russell Brown; Fiscal Year: 2004..Additionally, we plan a final roundtable discussion with all speakers to discuss the commonalities of the positive effects, underlying mechanisms, and adverse effects of nicotine as a potential therapy. ..
- NEUROTROPHIN CONTROL OF REM SLEEPJack Yamuy; Fiscal Year: 2004..This concerted set of experiments will be critical in elucidating the role that neurotrophins play in the control of REM sleep. ..
- Neuro-Immune Interactions in Developing AirwaysGary Larsen; Fiscal Year: 2005..These studies of developmental airway biology in mammalian species allow definition of neuro-immune mechanisms that may have relevance to events that occur in infants and small children. ..
- Ethanol Driven Neuroadaptation of Cholinergic InterneurADRIANA ALCANTARA; Fiscal Year: 2005..abstract_text> ..
- The Role of Acetylcholine Dysfunction in Diencephalic AmnesiaLisa M Savage; Fiscal Year: 2010..Such experiments are critical to understanding the role of acetylcholine dysfunction in amnesia and thus the development of pharmacotherapeutics. ..
- Signaling pathways directing cholinergic gene expressionBrygida Berse; Fiscal Year: 2004..Additionally, the importance of subcellular localization of TrkA for its action on cholinergic gene expression will be examined. ..
- Neuroimaging of Genetically-Defined Incipient CJDIsak Prohovnik; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- DYSKINESIAS IN LENTI-GDNF TREATED PARKINSONIAN MONKEYSJeffrey Kordower; Fiscal Year: 2006..This application will determine whether potent dopaminergic gene therapies influence dyskinesias in the best animal model of PD. ..
- CaMKI, Apoptosis and Cholinergic Neurons in Aging and ADChangiz Geula; Fiscal Year: 2007..They will also form the basis of more comprehensive future studies aimed at determining the causes and effects of the alterations of the above genes. [unreadable] [unreadable] [unreadable]..
- Two-Photon Microscopy for Biomedical ResearchBENJAMIN REESE; Fiscal Year: 2007..Acquisition of this 2-photon microscope will therefore enhance the diverse efforts of a number of investigators at UCSB in pursuit of their NIH-funded research objectives. [unreadable] [unreadable] [unreadable]..
- Cell Type-Specific Gene Delivery in Mammalian RetinaVijay Sarthy; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Muscarinic agonists for neurological disordersWilliam Messer; Fiscal Year: 2007..The studies outlined here will provide new approaches for the treatment of neurological disorders, including Alzheimer's disease and schizophrenia. ..
- Mechanisms of neurotrophin-improved cognition in agingANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2007..abstract_text> ..
- Clonidine Treatment for Neonatal Abstinence SyndromeEstelle Gauda; Fiscal Year: 2006..abstract_text> ..
- ROLE OF PROTEASOMAL DYSFUNCTION IN PARKINSON'S DISEASEKEVIN MCNAUGHT; Fiscal Year: 2008..These studies will test our hypothesis that inadequate proteasomal function underlies both vulnerability and degeneration of the SNc in sporadic Parkinson's disease. ..
- Muller Cell Role in Retinal DiseasesVijay P Sarthy; Fiscal Year: 2010..abstract_text> ..
- Cotinine for Cognitive Impairment in Neurological and Neuropsychiatric DisordersAlvin V Terry; Fiscal Year: 2010..The partly translational design of the study will provide results leading to eventual clinical trials with cotinine or a relevant analog. ..
- GENE EXPRESSION IN NERVOUS TISSUEBruce S McEwen; Fiscal Year: 2010..abstract_text> ..
- Neuroplasticity and the carotid bodyEstelle Gauda; Fiscal Year: 2009..abstract_text> ..
- Molecular Target(s) for Interruption of HBV InfectionJisu Li; Fiscal Year: 2009..We hope these studies will contribute to the understanding of the early events of hepadnavirus infection and may lead to the development of novel antiviral strategies for prevention of HBV induced liver cancer. ..
- Amygdala NPY, anxiety phenotypes and alcohol consumptionMARLENE WILSON; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Isolation and Characterization of Cholinesterases From Plaques and TanglesChangiz Geula; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- NEUROBIOLOGICAL MECHANISMS OF DRUG REINFORCEMENTJames Smith; Fiscal Year: 2008..abstract_text> ..
- MBRS SCORE Program at the Univ of Texas-BrownsvilleLUIS COLOM; Fiscal Year: 2007..Furthermore, the success of this application will contribute to the development of internal collaborations and the necessary scientific environment to develop successful R01 applications in the near future. ..
- Neurology of Attention and Neglect-A Network ApproachMarek Marsel Mesulam; Fiscal Year: 2008..The results of these experiments will help to understand the neurological bases of spatial attention and may lead to more rational treatments of hemispatial neglect. ..
- DUAL ENZYME-BASED MICROBIOSENSOR TO MEASURE ATP RELEASE FROM THE CAROTID BODYEstelle Gauda; Fiscal Year: 2008..This grant proposes to develop a microbiosensor to measure the release of ATP from the carotid body to understand how the newborn develops an adequate breathing response to changes in oxygen concentration. [unreadable] [unreadable]..
- Mutant Gene Identification in the Dystonic RatMark leDoux; Fiscal Year: 2008..Patients with dystonia will be screened for mutations in the human homologue. These proposed studies will likely increase our understanding of both dystonia and olivocerebellar motor systems. ..
- Female Reproductive Organs and Their Innervation.RAYMOND PAPKA; Fiscal Year: 2006..Finally, knowledge of estrogen responsive sensory neurons has important implications for understanding neuropathic pain syndromes influenced by estrogen levels. ..
- Molecular Foundations of the Myoclonus-Dystonia SyndromeMark leDoux; Fiscal Year: 2006..We hypothesize that epsilon sarcoglycan co-localizes with GABA receptors opposite GABAergic terminals in the central nervous system. ..
- LSM 510 Confocal MicroscopeRobert Gibbs; Fiscal Year: 2006..Acquisition of the requested instrument will eliminate this problem, and will provide the School of Pharmacy with a greatly needed resource. [unreadable] [unreadable] [unreadable]..
- NEUROANATOMICAL SUBSTRATES OF ALCOHOL-INDUCED AMNESIAAndrey Ryabinin; Fiscal Year: 2001..Taken together, these studies will provide valuable insight at several levels of analysis of alcohol~s action on cognitive functions and eventually allow to start understanding of the mechanisms involved in alcohol-induced amnesia. ..
- EYELID SENSORIMOTOR NETWORKSMark leDoux; Fiscal Year: 2003..abstract_text> ..
- BASAL GANGLIA CIRCUITRY IMMEDIATE EARLY GENE EXPRESSIONDavid Wirtshafter; Fiscal Year: 2003..Other studies will examine the effects of lesions within the basal ganglia on the IEG expression induced by systemic administration of dopaminergic drugs. ..
- DHEAS, SULFATASE INHIBITION & COGNITION IN LESIONED RATSDavid Johnson; Fiscal Year: 2003..Hippocampal levels of the neurotransmitters, ACh, glutamate and GABA as well as acetylcholinesterase activity in the basal forebrain will be determined. ..
- ROLE OF BASAL GANGLIA IN SONG LEARNING OF OSCINE BIRDSMICHAEL FARRIES; Fiscal Year: 2002..This research may ultimately contribute to the understanding and treatment of learning deficits in humans and diseases affecting the basal ganglia. ..
- NEUROBIOLOGICAL MECHANISMS OF ALCOHOL DRINKINGJames Smith; Fiscal Year: 2002..The proposed experiments will hopefully add significant new information to our understanding of the processes underlying alcohol abuse. ..
- Behavioral Genetics and Toxic ResponseEdward Levin; Fiscal Year: 2002....
- International meeting Neural Transplantation and RepairANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2002..In addition, previous statistics demonstrate that we have favored women and minorities in the past (33% of the travel award recipients for this years' meeting were women, and women serve on all the committees in our organization). ..
- IN SITU LIGATION FOR DETECTION OF SPECIFIC DNA DAMAGEDavid Baskin; Fiscal Year: 2001..It, therefore, can be used in molecular and cell biology research, as well as by clinicians in many fields, including pathology oncology, cardiology and the clinical neurosciences. ..
- SPINAL CORD REPAIR WITH HUMAN UMBILICAL CORD BLOOD CELLSSamuel Saporta; Fiscal Year: 2003..abstract_text> ..
- Auditory Cortex: Regional Pathology In SchizophreniaRobert Sweet; Fiscal Year: 2003..abstract_text> ..
- TETRAHYDROISOQUINOLINES AND PARKINSON'S DISEASEMark leDoux; Fiscal Year: 2006..Evolution may have not provided neurons with mechanisms to prevent accumulation of these by-products of normal metabolism and, as a consequence, susceptible neuronal populations may slowly undergo apoptotic death in the elderly. ..
- Antipsychotics: Temporal Effects on Cognitive FunctionAlvin Terry; Fiscal Year: 2006..unreadable] [unreadable]..
- Nicotinic-Antipsychotic Drug Interactions and CognitionEdward Levin; Fiscal Year: 2006..abstract_text> ..
- Cholinergic modulation of IEG expressionANN POWER; Fiscal Year: 2006..Experiment III will investigate which signaling cascades (e.g., protein kinases) are involved in effects of mR activation on memory and immediate early gene expression. ..
- Methylphenidate & gene expression in the rat brain.JOAN BAIZER; Fiscal Year: 2004..abstract_text> ..
- The Lateral Septum, Urocortin and AlcoholADAM WEITEMIER; Fiscal Year: 2004..Findings of this proposal will provide an important contribution to work highlighting the importance of stress- and anxiety-modulating neuropeptide systems in the regulation of alcohol-related behaviors. ..
- Role of Nonclassical Transmitters in Cardiac GangliaDonald Hoover; Fiscal Year: 2004..abstract_text> ..
- A New Tool for Targeted Antisense Knockdown in BrainRobert Gibbs; Fiscal Year: 2006..This will be the first time that a targeted antisense knockdown approach will have been developed and used to selectively regulate gene expression within an identified subpopulation of neurons in the adult brain. ..
- Mechanisms Underlying the Cognitive Function of SleepSubimal Datta; Fiscal Year: 2009....
- Adolescence: A Sensitive Period for Nicotine AddictionEdward Levin; Fiscal Year: 2008..unreadable] [unreadable]..
- CELL AND MOLECULAR BIOLOGY OF RETINAL MULLER CELLSVijay Sarthy; Fiscal Year: 2001..The importance of studying Muller cells is emphasized by their involvement in many human retinal diseases leading to blindness. ..
- Leak potassium channels in striatal cholinergic neuronsALLISON BERG; Fiscal Year: 2006..Finally, I confirm my findings using a mouse model in which TASK-3 is conditionally deleted (Specific Aim 3). ..
- Statistical methods in smoking cessation researchDaniel Heitjan; Fiscal Year: 2009..It is anticipated, however, that the resulting methods will be applicable more broadly to clinical research on outcomes that experience alternating periods of relapse and remission. ..
- CALBINDIN AND CHOLINERGIC NEURONS IN AGING AND ADChangiz Geula; Fiscal Year: 2002....
- Marine Toxin Impacts on Neurobehavioral FunctionEdward Levin; Fiscal Year: 2003..The forum will provide an opportunity for methodological and theoretical issues to be integrated in the context of each talk as well as in a discussion session at the end of the symposium. ..
- NEUROTRANSMITTER TRANSPORTERS IN THE RETINAVijay Sarthy; Fiscal Year: 2003....