Summary: A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC

Top Publications

  1. ncbi Myeloperoxidase: friend and foe
    Seymour J Klebanoff
    Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195 7185, USA
    J Leukoc Biol 77:598-625. 2005
  2. pmc The Ustilago maydis effector Pep1 suppresses plant immunity by inhibition of host peroxidase activity
    Christoph Hemetsberger
    Max Planck Institute for Terrestrial Microbiology, Marburg, Germany
    PLoS Pathog 8:e1002684. 2012
  3. pmc A peroxidase/dual oxidase system modulates midgut epithelial immunity in Anopheles gambiae
    Sanjeev Kumar
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Science 327:1644-8. 2010
  4. pmc Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides
    Sue Goo Rhee
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120 750, Korea
    J Biol Chem 287:4403-10. 2012
  5. pmc Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity
    Kathleen D Metzler
    Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany
    Blood 117:953-9. 2011
  6. pmc DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase
    Eva Andres-Mateos
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Suite 731, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:14807-12. 2007
  7. ncbi Intrinsic peroxidase-like activity of ferromagnetic nanoparticles
    Lizeng Gao
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China
    Nat Nanotechnol 2:577-83. 2007
  8. ncbi Evidence for the involvement of cell wall peroxidase in the generation of hydroxyl radicals mediating extension growth
    Anja Liszkay
    Institut fur Biologie II der Universitat, Schanzlestrasse 1, 79104 Freiburg, Germany
    Planta 217:658-67. 2003
  9. ncbi The apoplastic oxidative burst in response to biotic stress in plants: a three-component system
    G Paul Bolwell
    Division of Biochemistry, School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey TW20 0EX, UK
    J Exp Bot 53:1367-76. 2002
  10. ncbi Gastroprotective and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats
    Fehmi Odabasoglu
    Ataturk University, Faculty of Pharmacy, Department of Biochemistry, Erzurum, Turkey
    J Ethnopharmacol 103:59-65. 2006

Detail Information

Publications395 found, 100 shown here

  1. ncbi Myeloperoxidase: friend and foe
    Seymour J Klebanoff
    Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195 7185, USA
    J Leukoc Biol 77:598-625. 2005
    ..It is concluded that the MPO system plays an important role in the microbicidal activity of phagocytes...
  2. pmc The Ustilago maydis effector Pep1 suppresses plant immunity by inhibition of host peroxidase activity
    Christoph Hemetsberger
    Max Planck Institute for Terrestrial Microbiology, Marburg, Germany
    PLoS Pathog 8:e1002684. 2012
    ..strongly accumulated in the cell walls, coinciding with a transcriptional induction of the secreted maize peroxidase POX12...
  3. pmc A peroxidase/dual oxidase system modulates midgut epithelial immunity in Anopheles gambiae
    Sanjeev Kumar
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Science 327:1644-8. 2010
    ..matrices in diverse biological systems are cross-linked by dityrosine covalent bonds catalyzed by the peroxidase/oxidase system...
  4. pmc Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides
    Sue Goo Rhee
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120 750, Korea
    J Biol Chem 287:4403-10. 2012 cysteine of Prx can be reduced by a cellular thiol, thus enabling Prx to function as a locally constrained peroxidase. Regulation of Prx via phosphorylation in response to extracellular signals allows the local accumulation of H(2)..
  5. pmc Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity
    Kathleen D Metzler
    Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany
    Blood 117:953-9. 2011
    ..Finally, NET-dependent inhibition of Candida albicans growth is compromised in MPO-deficient neutrophils. The inability to form NETs may contribute in part to the host defense defects observed in completely MPO-deficient individuals...
  6. pmc DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase
    Eva Andres-Mateos
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Suite 731, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:14807-12. 2007
    ..but in older mice there is an up-regulation of mitochondrial manganese superoxide dismutase and glutathione peroxidase and a 2-fold increase in mitochondrial glutathione peroxidase activity...
  7. ncbi Intrinsic peroxidase-like activity of ferromagnetic nanoparticles
    Lizeng Gao
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China
    Nat Nanotechnol 2:577-83. 2007
    ..The stability, ease of production and versatility of these nanoparticles makes them a powerful tool for a wide range of potential applications in medicine, biotechnology and environmental chemistry...
  8. ncbi Evidence for the involvement of cell wall peroxidase in the generation of hydroxyl radicals mediating extension growth
    Anja Liszkay
    Institut fur Biologie II der Universitat, Schanzlestrasse 1, 79104 Freiburg, Germany
    Planta 217:658-67. 2003
    ..generation in the cell walls of growing plant organs represents an enzymatic reaction catalyzed by apoplastic peroxidase (POD). This hypothesis was investigated by supplying cell walls of maize ( Zea mays L...
  9. ncbi The apoplastic oxidative burst in response to biotic stress in plants: a three-component system
    G Paul Bolwell
    Division of Biochemistry, School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey TW20 0EX, UK
    J Exp Bot 53:1367-76. 2002
    ..treated with a cell wall elicitor from Colletotrichum lindemuthianum, appears to be dependent on an exocellular peroxidase. The second component, the extracellular alkalinization, occurs as a result of the Ca(2+) and proton influxes ..
  10. ncbi Gastroprotective and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats
    Fehmi Odabasoglu
    Ataturk University, Faculty of Pharmacy, Department of Biochemistry, Erzurum, Turkey
    J Ethnopharmacol 103:59-65. 2006
    ..of indomethacin caused a significant decrease in the levels of superoxide dismutase (SOD), glutathione peroxidase (GPx) and reduced glutathione (GSH), and an increase in the lipid peroxidation (LPO) level (p < 0.05)...
  11. ncbi Human myeloperoxidase in innate and acquired immunity
    Juergen Arnhold
    Institute for Medical Physics and Biophysics, Medical Faculty, University of Leipzig, Leipzig, Germany
    Arch Biochem Biophys 500:92-106. 2010
    ..Myeloperoxidase is a fascinating, multifunctional, and challenging enzyme that has not yet revealed all its secrets...
  12. pmc Myeloperoxidase targets apolipoprotein A-I, the major high density lipoprotein protein, for site-specific oxidation in human atherosclerotic lesions
    Baohai Shao
    Department of Medicine and Diabetes and Obesity Center of Excellence, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 287:6375-86. 2012
  13. ncbi Relationship between mutation of serine residue at 315th position in M. tuberculosis catalase-peroxidase enzyme and Isoniazid susceptibility: an in silico analysis
    Rituraj Purohit
    School of Bio Sciences and Technology, Bioinformatics Division, Vellore Institute of Technology University, Vellore, 632014 Tamil Nadu, India
    J Mol Model 17:869-77. 2011
    ..It is known that, activation of Isoniazid (INH) is mediated by Mycobacterium tuberculosis catalase-peroxidase (MtBKatG) and mutation at position 315 (serine to threonine) leads to resistance...
  14. ncbi Prognostic value of myeloperoxidase in patients with chest pain
    Marie Luise Brennan
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland 44195, USA
    N Engl J Med 349:1595-604. 2003
    ..Numerous lines of evidence suggest mechanistic links between myeloperoxidase and both inflammation and cardiovascular disease...
  15. ncbi Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide
    Heather Parker
    Department of Pathology, University of Otago Christchurch, 2 Riccarton Ave, Christchurch, New Zealand
    J Leukoc Biol 91:369-76. 2012
    ..Neutrophils were stimulated with PMA to release NETs. Peroxidase activity measurements were performed and showed that enzymatically active MPO was released from the neutrophils, ..
  16. ncbi Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes
    Stephan Baldus
    University of Hamburg, Department of Cardiology, Martinistrasse 52, 20246 Hamburg, Germany
    Circulation 108:1440-5. 2003
    ..However, whether MPO also provides prognostic information in patients with ACS remains unknown...
  17. pmc Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis
    Sander S Rensen
    Department of Surgery, Maastricht University Medical Centre, PO Box 616, Maastricht 6200 MD, The Netherlands
    Am J Pathol 175:1473-82. 2009
  18. ncbi Myeloperoxidase: molecular mechanisms of action and their relevance to human health and disease
    Betty S van der Veen
    Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Antioxid Redox Signal 11:2899-937. 2009
    Myeloperoxidase (MPO) is a heme-containing peroxidase abundantly expressed in neutrophils and to a lesser extent in monocytes...
  19. pmc Increased atherosclerosis in myeloperoxidase-deficient mice
    M L Brennan
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles UCLA, Los Angeles, California, USA
    J Clin Invest 107:419-30. 2001
    ..We have now generated MPO-deficient mice, and show here that neutrophils from homozygous mutants lack peroxidase and chlorination activity in vitro and fail to generate chlorotyrosine or to kill Candida albicans in vivo...
  20. ncbi The pepper extracellular peroxidase CaPO2 is required for salt, drought and oxidative stress tolerance as well as resistance to fungal pathogens
    Hyong Woo Choi
    Laboratory of Molecular Plant Pathology, School of Life Sciences and Biotechnology, Korea University, Anam Dong, Sungbuk Ku, Seoul 136 713, Republic of Korea
    Planta 235:1369-82. 2012
    In plants, biotic and abiotic stresses regulate the expression and activity of various peroxidase isoforms...
  21. ncbi Human umbilical cord blood-derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats
    Yun Sil Chang
    Department of Pediatrics, Samsung Medical Center, Kangnam Gu, Seoul, Republic of Korea
    Cell Transplant 18:869-86. 2009
    ..In conclusion, intratracheal transplantation of human UCB-derived MSCs is more effective than intraperitoneal transplantation in attenuating the hyperoxia-induced lung injury in neonatal rats...
  22. pmc Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase
    Michael O Breckwoldt
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, CNY 149, 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 105:18584-9. 2008
    ..Our findings could allow efficient noninvasive serial screening of therapies targeting inflammation and the use of MPO imaging as an imaging biomarker to risk-stratify patients...
  23. ncbi Myeloperoxidase attracts neutrophils by physical forces
    Anna Klinke
    Department of Cardiology, University Heart Center, Martinistrasse 52, Hamburg, Germany
    Blood 117:1350-8. 2011
    ..This electrostatic MPO effect not only displays a so far unrecognized, catalysis-independent function of the enzyme, but also highlights a principal mechanism of PMN attraction driven by physical forces...
  24. ncbi The MPO -463G>A polymorphism and cancer risk: a meta-analysis based on 43 case-control studies
    Haiyan Chu
    Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China
    Mutagenesis 25:389-95. 2010
    ..The results suggested that the MPO -463A allele does not contribute to the development of cancer. Additional well-designed large studies are required to validate these findings in different populations...
  25. ncbi Widespread coronary inflammation in unstable angina
    Antonino Buffon
    Institute of Cardiology, Catholic University, Rome
    N Engl J Med 347:5-12. 2002
    ..In unstable angina, activated leukocytes may be found in peripheral and coronary-sinus blood, but it is unclear whether they are selectively activated in the vascular bed of the culprit stenosis...
  26. ncbi Association between myeloperoxidase levels and risk of coronary artery disease
    R Zhang
    Department of Cell Biology, Cleveland Clinic Foundation, 9500 Euclid Ave, NC-10, Cleveland, OH 44195, USA
    JAMA 286:2136-42. 2001
    ..These findings support a potential role for MPO as an inflammatory marker in CAD and may have implications for atherosclerosis diagnosis and risk assessment...
  27. pmc Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease
    Lemin Zheng
    Department of Cell Biology, Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Clin Invest 114:529-41. 2004
    ..They also suggest a potential mechanism for MPO-dependent generation of a proatherogenic dysfunctional form of HDL in vivo...
  28. pmc Identification of a Ca(2+)-pectate binding site on an apoplastic peroxidase
    S Carpin
    , , , , Switzerland
    Plant Cell 13:511-20. 2001
    ..It can be concluded that APRX bears a Ca(2)+-pectate binding site formed by four clustered arginines. This site could ensure that APRX is properly positioned in cell walls, using unesterified domains of pectins as a scaffold...
  29. pmc Modification of high density lipoprotein by myeloperoxidase generates a pro-inflammatory particle
    Arundhati Undurti
    Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 284:30825-35. 2009
  30. ncbi Serum myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals: the EPIC-Norfolk Prospective Population Study
    Marijn C Meuwese
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 50:159-65. 2007
    ..We evaluated whether serum myeloperoxidase (MPO) levels are associated with the risk of future development of coronary artery disease (CAD) in apparently healthy individuals...
  31. pmc The pattern of distribution of pectin, peroxidase and lignin in the middle lamella of secondary xylem fibres in alfalfa (Medicago sativa)
    S G Wi
    College of Agriculture and Life Sciences, Chonnam National University, Yongbong dong 300, Buk Gu, Gwangju, 500 757 Korea
    Ann Bot 95:863-8. 2005
    ..This paper provides evidence of marked heterogeneity in the micro-distribution of lignin, pectin, peroxidase and hydrogen peroxide in the middle lamella of alfalfa (Medicago sativa).
  32. ncbi Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
    J P Eiserich
    Department of Internal Medicine, University of California, Davis 95616, USA
    Nature 391:393-7. 1998
    ..Our data reveal that NO2- may regulate inflammatory processes through oxidative mechanisms, perhaps by contributing to the tyrosine nitration and chlorination observed in vivo...
  33. pmc Bioluminescence imaging of myeloperoxidase activity in vivo
    Shimon Gross
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Med 15:455-61. 2009
    ..mice, despite massive tissue infiltration of neutrophils and activated eosinophils, indicating that eosinophil peroxidase did not contribute to luminol-BLI in vivo...
  34. pmc Peroxidase activity and structural transitions of cytochrome c bound to cardiolipin-containing membranes
    Natalia A Belikova
    Center for Free Radical and Antioxidant Health and Department of Environmental and Occupational Health, University of Pittsburgh, 100 Technology Drive, Suite 350, Pittsburgh, Pennsylvania 15219 3130, USA
    Biochemistry 45:4998-5009. 2006
    ..E., et al. (2005) Nat. Chem. Biol. 1, 223-232]. We quantitatively characterized the activation of peroxidase activity of cyt c by CL and hydrogen peroxide...
  35. ncbi Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome: implications for microbial killing
    Christine C Winterbourn
    Department of Pathology, Christchurch School of Medicine and Health Sciences, P O Box 4345, Christchurch, New Zealand
    J Biol Chem 281:39860-9. 2006
    ..Hydroxyl radicals should form only after all susceptible protein targets are consumed...
  36. ncbi Mammalian heme peroxidases: from molecular mechanisms to health implications
    Michael J Davies
    The Heart Research Institute, Camperdown, University of Sydney, Sydney, Australia, Faculty of Medicine, University of Sydney, Sydney, Australia
    Antioxid Redox Signal 10:1199-234. 2008
    A marked increase in interest has occurred over the last few years in the role that mammalian heme peroxidase enzymes, primarily myeloperoxidase, eosinophil peroxidase, and lactoperoxidase, may play in both disease prevention and human ..
  37. ncbi Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary disease
    Andrew Churg
    Department of Pathology and UBC James Hogg Research Centre, Institute for Heart and Lung Health, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 185:34-43. 2012
    ..Myeloperoxidase (MPO), a neutrophil and macrophage product, is important in bacterial killing, but also drives inflammatory reactions and tissue oxidation...
  38. pmc Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins
    Denise Lau
    Departments of Cardiology, Hepatobiliary Surgery, and Clinical Chemistry, University Hospital Hamburg Eppendorf, 20246 Hamburg, Germany
    Proc Natl Acad Sci U S A 102:431-6. 2005
    ..These cytokine-like properties of MPO thus represent an additional dimension of the proinflammatory actions of MPO in vascular disease...
  39. ncbi Myeloperoxidase, a leukocyte-derived vascular NO oxidase
    Jason P Eiserich
    Department of Internal Medicine, Division of Nephrology, University of California, Davis, CA 95616, USA
    Science 296:2391-4. 2002
    ..Altered vascular responsiveness was due to catalytic consumption of NO by substrate radicals generated by MPO. Thus MPO can directly modulate vascular inflammatory responses by regulating NO bioavailability...
  40. ncbi Neutrophils and immunity: challenges and opportunities
    Carl Nathan
    Department of Microbiology and Immunology, Weill Cornell Medical College, Weill Graduate School of Medical Sciences of Cornell University, Box 57, 1300 York Avenue, New York 10021, USA
    Nat Rev Immunol 6:173-82. 2006
  41. ncbi Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae)
    Candida Aparecida Leite Kassuya
    Department of Pharmacology, Universidade Federal do Parana, Curitiba, PR, Brazil
    J Ethnopharmacol 124:369-76. 2009
    ..This study investigated the antipyretic and anti-inflammatory effects of the ethanolic extract (EEMO), dichloromethane fraction (DCM), and the isolated compound costunolide...
  42. ncbi Graphene oxide-Fe3O4 magnetic nanocomposites with peroxidase-like activity for colorimetric detection of glucose
    Ya Lei Dong
    National Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China
    Nanoscale 4:3969-76. 2012
    In this report, graphene oxide-Fe(3)O(4) magnetic nanocomposites were demonstrated to possess intrinsic peroxidase-like activity and enhanced affinity toward H(2)O(2)...
  43. pmc Alternative complement pathway in the pathogenesis of disease mediated by anti-neutrophil cytoplasmic autoantibodies
    Hong Xiao
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Am J Pathol 170:52-64. 2007
  44. pmc Membrane-bound guaiacol peroxidases from maize (Zea mays L.) roots are regulated by methyl jasmonate, salicylic acid, and pathogen elicitors
    Angela Mika
    University of Hamburg, Biocenter Klein Flottbek and Botanical Garden, Plant Physiology, Ohnhorststrasse 18, D 22609 Hamburg, Germany
    J Exp Bot 61:831-41. 2010
    ..Total guaiacol peroxidase activities from soluble and microsomal fractions of maize roots were compared and showed weak changes...
  45. ncbi An aqueous pomegranate peel extract inhibits neutrophil myeloperoxidase in vitro and attenuates lung inflammation in mice
    Rafik Bachoual
    Faculte des Sciences de Gabes, Université de Gabès, Tunisia
    Food Chem Toxicol 49:1224-8. 2011
    ..So this study reveals that PGE inhibits neutrophil MPO activity and attenuates LPS-induced lung inflammation in mice. Inhibition of MPO activity by PGE could explain its anti-inflammatory action...
  46. ncbi Involvement of calcium-mediated effects on ROS metabolism in the regulation of growth improvement under salinity
    Michal Shoresh
    Institute of Soil, Water, and Environmental Sciences, Agricultural Research Organization, The Volcani Center, Bet Dagan 50 250, Israel
    Free Radic Biol Med 51:1221-34. 2011
    ..Salinity completely abolished apoplastic peroxidase activity. Supplemental Ca(2+) increased its activity only slightly...
  47. pmc Myeloperoxidase deficiency preserves vasomotor function in humans
    Tanja K Rudolph
    Cardiovascular Research Center and Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany
    Eur Heart J 33:1625-34. 2012
    ..Observational studies have suggested a mechanistic link between the leucocyte-derived enzyme myeloperoxidase (MPO) and vasomotor function. Here, we tested whether MPO is systemically affecting vascular tone in humans...
  48. ncbi Ulinastatin improves pulmonary function in severe burn-induced acute lung injury by attenuating inflammatory response
    Yong Fang
    Department of Burns and Plastic Surgery, No 3 People s Hospital, Shanghai, People s Republic of China
    J Trauma 71:1297-304. 2011
    ..Ulinastatin is potentially an effective intervention, because it attenuates the systemic inflammatory response induced by endotoxin and improves myocardial function during ischemic shock and reperfusion...
  49. ncbi Myeloperoxidase inhibition ameliorates multiple system atrophy-like degeneration in a transgenic mouse model
    Nadia Stefanova
    Division of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Anichstr 35, 6020 Innsbruck, Austria
    Neurotox Res 21:393-404. 2012
    ..This study suggests that MPO inhibition may represent a novel candidate treatment strategy against MSA-like neurodegeneration acting through its anti-inflammatory and anti-oxidative properties...
  50. pmc Regulation of ENaC-mediated alveolar fluid clearance by insulin via PI3K/Akt pathway in LPS-induced acute lung injury
    Wang Deng
    Department of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, China
    Respir Res 13:29. 2012
    ..The aim of this study was to investigate the effect of insulin on AFC in ALI and clarify the pathway in which insulin regulates the expression of ENaC in vitro and in vivo...
  51. ncbi Protein carbamylation links inflammation, smoking, uremia and atherogenesis
    Zeneng Wang
    Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Nat Med 13:1176-84. 2007
    ..We propose that protein carbamylation is a mechanism linking inflammation, smoking, uremia and coronary artery disease pathogenesis...
  52. ncbi Volatile anesthetic preconditioning attenuated sepsis induced lung inflammation
    Nurdan Bedirli
    Department of Anaesthesiology, Gazi University, Ankara, Turkey
    J Surg Res 178:e17-23. 2012
    ..This study aimed to evaluate the differential protective effects of isoflurane or sevoflurane on lung inflammation in a rat model of cecal ligation and puncture (CLP) induced sepsis...
  53. ncbi High plasma thiocyanate levels modulate protein damage induced by myeloperoxidase and perturb measurement of 3-chlorotyrosine
    Jihan Talib
    The Heart Research Institute, Newtown, Sydney, NSW 2042, Australia
    Free Radic Biol Med 53:20-9. 2012
  54. ncbi Hemin-graphene hybrid nanosheets with intrinsic peroxidase-like activity for label-free colorimetric detection of single-nucleotide polymorphism
    Yujing Guo
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China
    ACS Nano 5:1282-90. 2011
    ..First, H-GNs have intrinsic peroxidase-like activity, which can catalyze the reaction of peroxidase substrate, due to the existence of hemin on the ..
  55. pmc Myeloperoxidase: a front-line defender against phagocytosed microorganisms
    Seymour J Klebanoff
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Leukoc Biol 93:185-98. 2013
  56. ncbi Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice
    Dong Kug Choi
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Neurosci 25:6594-600. 2005
    ..This study demonstrates that MPO participates in the MPTP neurotoxic process and suggests that inhibitors of MPO may provide a protective benefit in PD...
  57. ncbi Flavonoids induced in cells undergoing nodule organogenesis in white clover are regulators of auxin breakdown by peroxidase
    U Mathesius
    Genomic Interactions Group, Research School of Biological Sciences, Australian National University, GPO Box 475, Canberra, ACT 2601, Australia
    J Exp Bot 52:419-26. 2001
    ..that specifically accumulate in cells undergoing early nodule organogenesis could affect auxin turnover by a peroxidase to explain local changes in auxin distribution that occur during nodule formation in white clover (Trifolium ..
  58. ncbi Elevated myeloperoxidase activity in white matter in multiple sclerosis
    Elizabeth Gray
    MS Laboratories, Burden Centre, University of Bristol Institute of Clinical Neurosciences, Frenchay Hospital, Bristol BS16 1JB, United Kingdom
    Neurosci Lett 444:195-8. 2008
    ..Demyelination in MS is associated with increased activity of MPO, suggesting that this production of reactive oxygen species may contribute to axonal injury within plaques...
  59. ncbi A new easy method for specific measurement of active myeloperoxidase in human biological fluids and tissue extracts
    T Franck
    Department of General Anaesthesia and Surgical Pathology of Large Animals, Veterinary Institute B 41, University of Liege, Sart Tilman, Liege, Belgium
    Talanta 80:723-9. 2009
  60. ncbi Oxidative stress and myeloperoxidase activity during bacterial meningitis: effects of febrile episodes and the BBB permeability
    Dijana Miric
    Institute of Biochemistry, Medical Faculty Pristina Kosovska Mirtovica, Anri Dinana bb, 38220, Kosovska Mitrovica, Serbia
    Clin Biochem 43:246-52. 2010
    ..To investigate participation of extracellular myeloperoxidase (MPO) in oxidative stress during different courses of the bacterial meningitis (BM)...
  61. ncbi IgG subclass distribution, affinity of anti-myeloperoxidase antibodies in sera from patients with Wegener's granulomatosis and microscopic polyangiitis
    Li Jun Liu
    Renal Division, Department of Medicine Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China
    Nephrology (Carlton) 13:629-35. 2008
    ..The aim of this study was to compare the immunological characteristics of MPO-ANCA in patients with WG and MPA...
  62. ncbi ANCA-associated vasculitis: diagnostic and therapeutic strategy
    Shoichi Ozaki
    Division of Rheumatology and Allergy, Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
    Allergol Int 56:87-96. 2007
    ..This article describes the diagnostic criteria and the recent evidence-based therapeutic strategy of AAV...
  63. ncbi Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions: PON1 esterase and peroxidase-like activities
    M Aviram
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel
    Circulation 101:2510-7. 2000
    ..PON1 protects LDL from oxidation, and during LDL oxidation, PON1 is inactivated...
  64. ncbi Sevoflurane protects against acute kidney injury in a small-size liver transplantation model
    H Y Kong
    Department of Anesthesiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, PR China
    Am J Nephrol 32:347-55. 2010
  65. ncbi Myeloperoxidase inactivates TIMP-1 by oxidizing its N-terminal cysteine residue: an oxidative mechanism for regulating proteolysis during inflammation
    Yi Wang
    Department of Medicine, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington 98195, USA
    J Biol Chem 282:31826-34. 2007
    ..Our findings suggest that pericellular production of HOCl by phagocytes is a pathogenic mechanism for impairing TIMP-1 activity during inflammation...
  66. ncbi General peroxidase activity of G-quadruplex-hemin complexes and its application in ligand screening
    Xiaohong Cheng
    Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
    Biochemistry 48:7817-23. 2009
    ..Here we report the general peroxidase activity of G-quadruplex-hemin complexes and discuss the connection between peroxidase activity and G-quadruplex ..
  67. pmc Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats
    Xin Zhang
    Department of Pharmacology, Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, Kyoto 601 8550, Japan
    World J Gastroenterol 14:4784-90. 2008
    ..To investigate the mucosal protective effect and the mechanisms of action of the anti-ulcer drug irsogladine maleate in gastric injury induced by indomethacin in rats...
  68. ncbi Identification of phenolic compounds in isolated vacuoles of the medicinal plant Catharanthus roseus and their interaction with vacuolar class III peroxidase: an H₂O₂ affair?
    Federico Ferreres
    Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS CSIC, PO Box 164, E 30100 Campus University Espinardo Murcia, Spain
    J Exp Bot 62:2841-54. 2011
    ..Therefore, it is proposed that the vacuolar couple Prx/secondary metabolites represent an important sink/buffer of H(2)O(2) in green plant cells...
  69. pmc Antibodies to selected minor target antigens in patients with anti-neutrophil cytoplasmic antibodies (ANCA)
    M V Talor
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Clin Exp Immunol 150:42-8. 2007
    ..While the pathophysiological significance of antibodies to minor target antigens needs further evaluation, they may be markers of inflammation associated with disease processes...
  70. pmc Hydrogen sulfide therapy attenuates the inflammatory response in a porcine model of myocardial ischemia/reperfusion injury
    Neel R Sodha
    Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass, USA
    J Thorac Cardiovasc Surg 138:977-84. 2009
    ..This study investigates the cardioprotection provided by exogenous hydrogen sulfide and its potential anti-inflammatory mechanism of action...
  71. ncbi Overexpression of sweetpotato swpa4 peroxidase results in increased hydrogen peroxide production and enhances stress tolerance in tobacco
    Yun Hee Kim
    Environmental Biotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Oun Dong, Yusong gu, Daejeon 305 806, Korea
    Planta 227:867-81. 2008
    ..These results suggest that the expression of swpa4 in the apoplastic space may function as a positive defense signal in the H(2)O(2)-regulated stress response signaling pathway...
  72. pmc Usefulness of myeloperoxidase levels in healthy elderly subjects to predict risk of developing heart failure
    W H Wilson Tang
    Department of Cell Biology, Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Cardiol 103:1269-74. 2009
    ..In conclusion, an independent association between increased MPO and the development of HF in apparently healthy elderly subjects was observed, particularly beyond MI and traditional cardiac risk factors...
  73. ncbi Gastric antisecretory and antiulcer effects of simvastatin in rats
    Mohammad Tariq
    Research Center, Armed Forces Hospital, Riyadh, Saudi Arabia
    J Gastroenterol Hepatol 22:2316-23. 2007
    ..This investigation aimed to study the effect of SIM on experimentally induced gastric acid secretion and ulcer formation...
  74. ncbi Immunohistochemical evidence for the myeloperoxidase/H2O2/halide system in human atherosclerotic lesions: colocalization of myeloperoxidase and hypochlorite-modified proteins
    E Malle
    Institute of Medical Biochemistry and Biochemistry, Karl Franzens University Graz, Austria
    Eur J Biochem 267:4495-503. 2000
    ..We propose that MPO could act as an important link between the development of atherosclerotic plaque in the artery wall and chronic inflammatory events...
  75. ncbi The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature
    Fernanda M Coelho
    Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Arthritis Rheum 58:2329-37. 2008
    ..We undertook this study to investigate the role of these receptors in mediating neutrophil adhesion, subsequent migration, and neutrophil-dependent hypernociception in a murine model of monarticular antigen-induced arthritis (AIA)...
  76. ncbi Reactions of superoxide with myeloperoxidase and its products
    Christine C Winterbourn
    Free Radical Research, Department of Pathology, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Jpn J Infect Dis 57:S31-3. 2004
    ..Superoxide also reacts rapidly with radicals generated by MPO, e.g. from tyrosine and tyrosyl peptides. Initial products are organic peroxides. These species are likely to be toxic and contribute to the pathophysiological actions of MPO...
  77. ncbi Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion
    Hajime Kin
    Department of Cardiothoracic Surgery, The Carlyle Fraser Heart Center Crawford Long Hospital, Emory University School of Medicine, Atlanta, GA 30308 2225, USA
    Cardiovasc Res 62:74-85. 2004
    ..This study tested the hypothesis that the early minutes of reperfusion (R) during which postconditioning (Post-con) is applied are critical to its cardioprotection...
  78. pmc Aspergillus nidulans catalase-peroxidase gene (cpeA) is transcriptionally induced during sexual development through the transcription factor StuA
    Mario Scherer
    Laboratorium für Mikrobiologie, Philipps Universität Marburg and Max Planck Institut für Terrestrische Mikrobiologie, D 35043 Marburg, Germany
    Eukaryot Cell 1:725-35. 2002
    ..The latter activity is probably due to the bifunctional enzyme catalase-peroxidase, which we characterized here...
  79. ncbi Substrate oxidation sites in versatile peroxidase and other basidiomycete peroxidases
    Francisco J Ruiz-Dueñas
    CIB, CSIC, Ramiro de Maeztu 9, 28040 E Madrid, Spain
    J Exp Bot 60:441-52. 2009
    Versatile peroxidase (VP) is defined by its capabilities to oxidize the typical substrates of other basidiomycete peroxidases: (i) Mn(2+), the manganese peroxidase (MnP) substrate (Mn(3+) being able to oxidize phenols and initiate lipid ..
  80. ncbi Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase
    Stephan Baldus
    Department of Cardiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Circulation 113:1871-8. 2006
    ..In the present study, we investigated whether heparin mobilizes MPO from vascular compartments in humans and defined whether this translates into increased vascular NO bioavailability and function...
  81. ncbi Novel drug development opportunity for relaxin in acute myocardial infarction: evidences from a swine model
    Avio Maria Perna
    Unit of Cardiac and Experimental Surgery, Careggi Hospital, Florence, Italy
    FASEB J 19:1525-7. 2005
    ..The findings also provide background to future clinical trials with relaxin as adjunctive therapy to catheter-based coronary angioplasty in patients with acute myocardial infarction...
  82. ncbi Myeloperoxidase
    C C Winterbourn
    Department of Pathology, Christchurch School of Medicine, New Zealand
    Curr Opin Hematol 7:53-8. 2000
    ..These links with inflammatory diseases can now be pursued further using specific biomarkers of myeloperoxidase activity...
  83. ncbi Beneficial effects of N-acetylcysteine on acetic acid-induced colitis in rats
    Ali Cetinkaya
    Department of Internal Medicine, Medical Faculty, Sutcuimam University, Kahramanmaras, Turkey
    Tohoku J Exp Med 206:131-9. 2005
    ..But there was no significant increase in catalase activity. In conclusion, N-acetylcysteine could be beneficial as a complementary agent in treatment of ulcerative colitis...
  84. pmc Myeloperoxidase: a target for new drug development?
    E Malle
    Center of Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria
    Br J Pharmacol 152:838-54. 2007
    Myeloperoxidase (MPO), a member of the haem peroxidase-cyclooxygenase superfamily, is abundantly expressed in neutrophils and to a lesser extent in monocytes and certain type of macrophages...
  85. ncbi Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation
    Valerian E Kagan
    Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Nat Nanotechnol 5:354-9. 2010
    ..carbon nanotubes can be catalytically biodegraded over several weeks by the plant-derived enzyme, horseradish peroxidase. However, whether peroxidase intermediates generated inside human cells or biofluids are involved in the ..
  86. pmc Anti-neutrophil cytoplasm antibody IgG subclasses in Wegener's granulomatosis: a possible pathogenic role for the IgG4 subclass
    M Holland
    MRC Centre for Immune Regulation, The Medical School, University of Birmingham, Birmingham, UK
    Clin Exp Immunol 138:183-92. 2004
  87. pmc C5a receptor mediates neutrophil activation and ANCA-induced glomerulonephritis
    Adrian Schreiber
    Medical Faculty of the Charite, Department of Nephrology and Hypertension, Franz Volhard Clinic at the Max Delbrück Center for Molecular Medicine, HELIOS Klinikum Berlin, Berlin, Germany
    J Am Soc Nephrol 20:289-98. 2009
    ..05). In summary, C5a and the neutrophil C5aR may compose an amplification loop for ANCA-mediated neutrophil activation. The C5aR may provide a new therapeutic target for ANCA-induced necrotizing crescentic glomerulonephritis...
  88. ncbi Neutrophil infiltration of culprit lesions in acute coronary syndromes
    Takahiko Naruko
    Department of Cardiology, Osaka City General Hospital, Osaka
    Circulation 106:2894-900. 2002
    ..Neutrophils in unstable atherosclerotic lesions have not received much consideration, despite accumulating evidence suggesting a link between systemic inflammation and acute coronary syndromes...
  89. ncbi Therapeutic effect of epigallocatechin-3-gallate in a mouse model of colitis
    Patricia A Abboud
    Cincinnati Children s Hospital Medical Center, Division of Critical Care Medicine, College of Medicine, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Eur J Pharmacol 579:411-7. 2008
    ..Our data demonstrate that EGCG may be beneficial in colitis through selective immunomodulatory effects, which may be mediated, at least in part, by inhibition of NF-kappaB and AP-1...
  90. pmc Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation
    Volker Rudolph
    1Department of General and Interventional Cardiology and Cardiovascular Research Center, University Heart Center, Hamburg, Germany
    Nat Med 16:470-4. 2010
    ..Our data demonstrate that MPO is a crucial prerequisite for structural remodeling of the myocardium, leading to an increased vulnerability to atrial fibrillation...
  91. ncbi Characterization of the differentiated antioxidant profile of human saliva
    Rafael M Nagler
    Department of Oral and Maxillofacial Surgery, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Center, Haifa, Israel
    Free Radic Biol Med 32:268-77. 2002
    ..For example, peroxidase, superoxide dismutase, uric acid, and total antioxidant status were higher in resting parotid saliva compared ..
  92. ncbi Role of mitogen-activated protein kinases in activation of human neutrophils by antineutrophil cytoplasmic antibodies
    R Kettritz
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    J Am Soc Nephrol 12:37-46. 2001
    ..However, both pathways show differential effects, whereby p38-MAPK controls the translocation of ANCA antigens to the cell surface...
  93. pmc IgG glycan hydrolysis attenuates ANCA-mediated glomerulonephritis
    Mirjan M van Timmeren
    Departments of Pathology and Medical Biology, University Medical Center Groningen and University of Groningen, Groningen, Netherlands
    J Am Soc Nephrol 21:1103-14. 2010
    ..Systemic treatment with EndoS early after disease induction attenuates the development of disease. Thus, modulation of IgG glycosylation is a promising strategy to interfere with ANCA-mediated inflammatory processes...
  94. pmc Rapid deposition of extensin during the elicitation of grapevine callus cultures is specifically catalyzed by a 40-kilodalton peroxidase
    P A Jackson
    , Apartado 127, 2781-901 Oeiras, Portugal
    Plant Physiol 127:1065-76. 2001
    ..The deposition of GvP1 in situ requires peroxide and endogenous peroxidase activity...
  95. pmc The link between thyroid autoimmunity (antithyroid peroxidase autoantibodies) with anxiety and mood disorders in the community: a field of interest for public health in the future
    Mauro Giovanni Carta
    Department of Public Health, Division of Psychiatry, University of Cagliari, Italy
    BMC Psychiatry 4:25. 2004
    ..To evaluate the association between mood and anxiety disorders and thyroid autoimmunity in a community sample...
  96. ncbi Mesenchymal stem cell-based angiopoietin-1 gene therapy for acute lung injury induced by lipopolysaccharide in mice
    J Xu
    Department of Pulmonary Medicine, Zhongshan Hospital, State Key Laboratory of Genetic Engineering, Shanghai Medical College, Fudan University, People s Republic of China
    J Pathol 214:472-81. 2008
    ..These results suggest that MSCs and Ang1 have a synergistic role in the treatment of LPS-induced lung injury. MSC-based Ang1 gene therapy may be developed as a potential novel strategy for the treatment of acute lung injury...
  97. pmc Myeloperoxidase is critically involved in the induction of organ damage after renal ischemia reperfusion
    Robert A Matthijsen
    Department of General Surgery, Research Institute Maastricht, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
    Am J Pathol 171:1743-52. 2007
    ..Taken together, these results demonstrated an important contribution of MPO in the induction of organ damage after renal I/R by influencing critical factors such as neutrophil extravasation but not complement activation...
  98. pmc Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction
    Arman T Askari
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Exp Med 197:615-24. 2003
    ..These data offer a mechanistic link between inflammation and LV remodeling by demonstrating a heretofore unrecognized role for MPO and PAI-1 in orchestrating the myocardial response to AMI...
  99. pmc Myeloperoxidase produces nitrating oxidants in vivo
    Joseph P Gaut
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 109:1311-9. 2002
    ..This article was published online in advance of the print edition. The date of publication is available from the JCI website,
  100. pmc The role of neutrophils in the induction of glomerulonephritis by anti-myeloperoxidase antibodies
    Hong Xiao
    Department of Pathology and Laboratory Medicine, University of North Carolina, 303 Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
    Am J Pathol 167:39-45. 2005
    ..This raises the possibility that therapeutic strategies to reduce circulating neutrophils could be beneficial to patients with ANCA-induced NCGN...
  101. pmc Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure
    V Y Melnikov
    Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    J Clin Invest 107:1145-52. 2001
    ..Finally, we confirmed histologically that caspase-1(-/-) mice show decreased neutrophil infiltration, indicating that the deleterious role of IL-18 in ischemic ARF may be due to increased neutrophil infiltration...

Research Grants75

  1. Correction of glutathione deficiency for treatment of diabetic nephropathy
    Paolo Fanti; Fiscal Year: 2013
    ..are inducers of many cellular enzymes participating in GSH metabolism, including GSH-reductase (GSH-R), GSH-peroxidase (GSH-Px), GSH-S-transferases (GST) and superoxide dismutase (SOD)...
  2. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Evidence implicates a role for heme-containing peroxidase in atherogenesis due in part to oxidation of low density lipoprotein (LDL)...
  3. Arsenic Trioxide and Acute Myeloid Leukemia
    Yongkui Jing; Fiscal Year: 2012
    ..ROS generated as a byproduct of mitochondrial respiration are detoxified by glutathione-enzymes, glutathione peroxidase (GPx), glutathione-s-transferase ? (GST?) and glutathione reductase (GR)...
  4. Role of Glutathione S-Transferase P in Heart Failure
    Sumanth D Prabhu; Fiscal Year: 2013
    ..In tissue homogenates, we will also determine GSTP-related peroxidase activity and levels of aldehydes and lipid peroxides...
  5. Predicting Bilirubin-induced Auditory Toxicity in Infants with Severe Jaundice
    Sanjiv B Amin; Fiscal Year: 2010
    ..The unbound bilirubin will be measured by the peroxidase method using an FDA approved UB analyzer in Rochester...
  6. N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
    Paolo Fanti; Fiscal Year: 2011
    ..are inducers of many cellular enzymes participating in GSH metabolism, including GSH-reductase (GSH-R), GSH-peroxidase (GSH-Px), GSH-S-transferases (GST) and superoxide dismutase (SOD)...
  7. The Effects of PP2A on TNF Signaling and Smoke-Induced Lung Injury
    Robert F Foronjy; Fiscal Year: 2013
    ..Further studies in our laboratory demonstrate that the transgenic expression of human SOD1 and glutathione peroxidase-1 (GPX1) decreases JNK activation and AP-1 signaling within the lungs of mice...
    Sandra M McLachlan; Fiscal Year: 2012
    ..depleted of Treg induces thyroid lymphocytic infiltrates, hypothyroidism and murine thyroglobulin and thyroid peroxidase antibodies. Mice without infiltrates lack these antibodies...
  9. TNF-alpha Signaling in Silica-Induced Lung Fibrosis
    Luis A Ortiz; Fiscal Year: 2012
    ..The mechanisms responsible for the silica-induced oxidation of CL are unknown but may involve the peroxidase activity of cytochrome c (cyt c)...
  10. Targeted investigation of tissue specific oxidative stress in the etiology of ALS
    Holly Van Remmen; Fiscal Year: 2013
    ..hydroperoxides, a conditional knockout mouse carrying floxed alleles for phospholipid hydroperoxide glutathione peroxidase (Gpx4flfl mice). Gpx4 plays a critical role in protecting membranes by removal of lipid hydroperoxides...
  11. Molecular Epidemiology of Chronic Liver Diseases
    Manal Hassan; Fiscal Year: 2009
    ..e., catalase, glutathione peroxidase, superoxide dismutases, TNF- alpha, and TGF beta1, IL-11, COX2) and genes of DNA repair (i.e...
  12. Timing of Exposure to Selenium and Isoflavones and Prostate Cancer Prevention
    EDWIN DOUGLAS LEPHART; Fiscal Year: 2010
    ..Se-dependent glutathione peroxidase and 5alpha-reductase activities will be assayed. AR and NF-:B activation will be determined by EMSA...
  13. Identification of small molecule inhibitors of protein disulfide isomerase
    ROBERT C FLAUMENHAFT; Fiscal Year: 2012
    ..a fluorescence-based assay of insulin aggregation, remove non-specific oxidase inhibitors using a glutathione peroxidase assay, and determine the specificity of inhibitors using alternative oxidoreductases, including ERp5, ERp46, ..
  14. Cardioprotective Mechanisms of Glutathione S-transferase P
    DANIEL JOSEPH CONKLIN; Fiscal Year: 2012
    ..To delineate the contribution of GSTP, we will compare metabolic pathways, including aldehyde conjugation and peroxidase activity, in hearts isolated of GSTP WT, null, and TG mice...
  15. Respiratory and Metabolic Adaptation to Hypoxia
    Paul T Schumacker; Fiscal Year: 2013
    ..We hypothesize that Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx) functions as a signal transduction messenger in the ROS-HIF-1a pathway, transmitting the hypoxia-induced ..
  16. Thioredoxin and Endothelial Cell Function
    Wang Min; Fiscal Year: 2012 mitochondria-specific thioredoxin (Trx2) system, consisting of Trx2, Trx2 reductase (TrxR2) and Trx2-depndent peroxidase (Prx3). Little is known for the role of mitochondrial Trx2 system in vasculature...
  17. Oxidative Lipidomics in Pediatric Traumatic Brain Injury
    Hulya Bayir; Fiscal Year: 2012
    ..efficacy of novel mitochondria-targeted compounds acting via different pathways to regulate CL/cyt c peroxidase activity...
    Darlene A Dartt; Fiscal Year: 2012
    ..secretory deficit and no inflammation, and 3. secretory deficit and inflammation. For in vitro studies peroxidase activity, FACS analysis, western blotting, ELISA, immunoprecipitation, single cell Ca2+, WST-8, and ..
  19. Mitochondrial Proteins in Parkinson's Disease
    J Timothy Greenamyre; Fiscal Year: 2013
    ..c may prevent apoptosome formation while also promoting oxidative stress via a novel peroxidase activity...
  20. Mechanistic Studies of Alkyl Hydroperoxide Reductase and Related Redox Proteins
    Leslie B Poole; Fiscal Year: 2013
    ..Catalase and glutathione peroxidase have long been viewed as the major enzymes degrading peroxide in cells, however, over the past few years, a ..
  21. Peroxiredoxin 6 and Cataractogenesis
    Dhirendra P Singh; Fiscal Year: 2010
    ..Peroxiredoxin 6 (PRDX6), a 'moonlighting protein'with both GSH peroxidase and aiPLA2 (acidic Ca2+independent phospholipase A2) activities, is highly expressed in lens...
  22. Biological Mechanisms of Arterial Stiffening With Age and Estrogen Deficiency
    KERRIE MOREAU; Fiscal Year: 2010
    ..g., NADPH) and antioxidant (e.g., glutathione peroxidase) enzymes, vasoconstrictors (endothelin- 1), and estrogen receptor alpha (ERalpha)...
  23. Oxidative and nitrosative stress resistance of Cryptococcus neoformans
    Jennifer K Lodge; Fiscal Year: 2010
    ..Given that the thioredoxins have been thought to be critical for the recycling of the thiol peroxidase and that Tsa1 is localized in the cell periphery, the precise localization (cell wall, cell membrane, membrane ..
    Lynn Soong; Fiscal Year: 2012
    ..their contributions, we will use mice deficient in the oxidative stress pathways (NADPH oxidase, glutathione peroxidase, and superoxide dismutase)...
  25. The Role of Peroxiredoxin1 &Reactive Oxygen Species in Breast Tumor Initiation
    Carola Anke Neumann; Fiscal Year: 2013
    ..We have shown that mice lacking one or two copies of the peroxidase Prdx1 die prematurely of hemolytic anemia and multiple cancers...
  26. Diagnostic Tests and Immunotherapy of Sarcoidosis Using Mycobacterial Proteins
    David R Moller; Fiscal Year: 2012
    ..Our specific approach capitalizes on our recent discovery that IVIycobacterium tuberculosis catalase-peroxidase (mKatG) is a prototypic pathogenic tissue antigen in sarcoidosis...
    FRANCIS S contact MILLETT; Fiscal Year: 2010
    ..between cytochrome c and its physiological partners, cytochrome c oxidase, cytochrome bc1, and cytochrome c peroxidase. A new ruthenium dimer has recently been developed which binds with high affinity to cytochrome bc1 and can ..
  28. Antioxidative role of GPX1 in transgenic mice.
    XINGEN LEI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cellular glutathione peroxidase-1 (GPX1) is the first identified selenium-dependent protein and a major intracellular antioxidant enzyme in mammals...
  29. Eosinophil Peroxidase in Allergic Inflammation
    Arne Slungaard; Fiscal Year: 2012
    ..EO specific granules are endowed with abundant amounts of EO peroxidase (EPO) and a vigorous respiratory burst that generates H2O2 to fuel the generation of other oxidants...
  30. Molecular Pathobiology of Barrett's Tumorigenesis
    Wael El-Rifai; Fiscal Year: 2013
    ..Using integrated analysis approaches, we have identified silencing of glutathione peroxidase 7 (GPX7) in two-thirds of BACs. GPX7 is a recently identified member of the GPX family...
  31. Oxidant Mechanisms in Neonatal Brain Injury
    Donna M Ferriero; Fiscal Year: 2013 H2O2 to generate a cytoprotective response through the use of HIF conditional knockouts and glutathione peroxidase transgenics and knockouts...
    Vickram Ramkumar; Fiscal Year: 1999
    ..the cell from free radicals and comprises enzymes such as superoxide dismutase (SOD), catalase CAT), glutathione peroxidase (GSH...
  33. Mapping Lipid Oxidation in Traumatic Brain Injury by Mass Spectrometric Imaging
    Valerian E Kagan; Fiscal Year: 2013
    ..novel mitochondria targeted electron scavengers (gramicidin conjugated nitroxides) and inhibitors of cyt c/ CL peroxidase (triphenylphosphonium conjugated imidazole fatty acids) will facilitate our ability to pharmacologically ..
  34. Dengue diagnostics using a novel peroxidase chain reaction (PxCR)
    PETER PETER ZASSENHAUS; Fiscal Year: 2013
    ..We call it the peroxidase chain reaction - PxCR...
  35. The role of peroxidasin in Goodpasture's disease
    ABRAHAM SCOTT MCCALL; Fiscal Year: 2013
    ..We hypothesize that anti-peroxidasin antibodies target the peroxidase domain and inactivate S=N bond forming activity...
    Peter Arvan; Fiscal Year: 2012
    ..accumulation of iodide with eventual transport apically where, in conjunction with H2O2 generation and peroxidase activity, Tg becomes iodinated to form both iodotyrosines and iodothyronines...
  37. Dual Function of VPO1 in Pathogen Recognition and Killing
    Guangjie Cheng; Fiscal Year: 2013
    ..Whether there is a PRR to directly kill invading microorganisms remains to be elucidated. Vascular peroxidase 1 (VPO1) is a newly-discovered mammalian heme-containing peroxidase (hPx)...
  38. Selenium Colorectal Cancer Chemoprevention Trials
    PATRICIA ANN THOMPSON; Fiscal Year: 2013
    ..mechanism for Se-related T2D in human is obscure, animal studies suggest that chronic activation of glutathione peroxidase 1 (GPX1), a potent anti-oxidant selenoprotein, may lead to the development of hyperinsulinemia, hyperglycemia, ..
  39. Cardiovascular Disease Biomarkers and Mediation of Hormone Therapy Effects
    Ross L Prentice; Fiscal Year: 2012
    ..For CHD these are alpha-1-acid glycoprotein 1, thrombospondin 1, complement factor D preprotein, glutathione peroxidase 3, and insulin-like binding protein 1 (IGFBP1)...
  40. Mechanism of Peroxiredoxin 3 in a Model of Pesticide-Mediated Neurodegeneration
    JAMES R ROEDE; Fiscal Year: 2012
    ..However, recent data show that peroxiredoxin 3 (Prx3), a peroxidase supported by the antioxidant thioredoxin-2 (Trx2), has a predominant role in mitochondrial peroxide metabolism...
  41. Eosinophils and lung immunity to Pneumocystis
    Chad Steele; Fiscal Year: 2013
    ..Higher Epx (eosinophil peroxidase) mRNA expression was observed in Src TKO mice, which have a higher M2a signature and clear P...
  42. Development of genetically encoded neural tracers for electron microscopy
    Linnaea E Ostroff; Fiscal Year: 2012
    ..Using a viral vector, we will express a membrane-targeted form of the EM label horseradish peroxidase (HRP) in adult rat neurons...
  43. Redox Mechanisms of Chemoprevention in Lung by Selenium Supplementation
    ROBYN POERSCHKE; Fiscal Year: 2010
    ..response element (ARE) genes, including the selenoproteins thioredoxin reductase 1 (TrxRI) and glutathione peroxidase 2 (GPx2)...
  44. Selenium as an adjuvant to imatinib therapy
    Alan Diamond; Fiscal Year: 2010
    ..shown that imatinab also inhibits the activating phosphorylation of the selenium-dependent enzyme glutathione peroxidase (GPx-1)...
  45. Asthma Inflammation Research (AIR)
    Serpil C Erzurum; Fiscal Year: 2013
    ..extracellular matrix that impedes resolution of inflammation (project 3);and the recently uncovered eosinophil peroxidase-catalyzed protein modification of carbamylation that is linked to tobacco-smoke exposure, and independent of ..
  46. Role of Prdx6 in the activation of NADPH oxidase
    Aron B Fisher; Fiscal Year: 2013
    ..We postulate that this agent will maintain the protective peroxidase activity of Prdx6 while inhibiting the activation of NOX2...
    Joan Selverstone Valentine; Fiscal Year: 2010 zinc superoxide dismutase (Sod1p), CCS (copper chaperone for Sod1p), and cytochrome c peroxidase. First, we propose a series of biological and genetic experiments designed to explore the roles of these ..
  48. Eosinophilic Myocarditis
    Noel R Rose; Fiscal Year: 2013
    ..effects of blockade of one of the major products that eosinophils release upon activation, eosinophil peroxidase (EPO)...
  49. Evaluation of Recombinant Human Lactoferrin as an Osteogenic Biomaterial
    Ashley A Amini; Fiscal Year: 2013
    ..We hypothesize that varying concentrations of the three gel components, horseradish peroxidase (HRP), modified rhLF and H2O2, will directly affect the water uptake, mechanical strength, morphology and in ..
  50. Peroxiredoxin 6 as an Anti-oxidant Enzyme
    Aron B Fisher; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This project will evaluate the properties of a novel glutathione peroxidase enzyme that is considerably enriched in lungs and plays an important role in lung antioxidant defense and lung surfactant ..
  51. GPx-3 and Peroxide Flux in the Endothelial Cell
    Joseph Loscalzo; Fiscal Year: 2013
    ..The central hypothesis of this award is that glutathione peroxidase-3 (GPx-3) is a principal determinant of extracellular hydrogen peroxide flux from the endothelial cell, and a ..
  52. Glutathione Peroxidase & Redox State in Atherosclerosis
    Francis Miller; Fiscal Year: 2009
    ..Glutathione (GSH) is the most abundant redox buffer in the cell. The cytosolic enzyme glutathione peroxidase-1 (GPx-1) protects the cell against oxidant stress by utilizing GSH to reduce hydrogen peroxide and lipid ..
  53. Modeling Prostate Tumorigenesis
    Sarki A Abdulkadir; Fiscal Year: 2012
    ..1 dysregulates the expression of pro- and anti-oxidant enzymes (including peroxiredoxin 6, glutathione peroxidase 3 and sulfhydryl oxidase 6) resulting in loss of protection against oxidative damage...
  54. Quantitative molecular profiling of tumor biomarkers with multi-color monovalent
    Hongyan Liu; Fiscal Year: 2012
    ..tumor plays a crucial role in the diagnosis and treatment cancers and are challenging the current method of peroxidase-based immunohistochemistry which is not stoichiometric and only one stain can be done on a section...
  55. Arterial Dysfunction: Basic and Clinical Mechanisms
    Thomas Michel; Fiscal Year: 2013
    ..J. Loscaizo leads Project 4, "Glutathione peroxidase-1, mitochondrial function, and endothelial phenotype", and also is Co-Director of the Redox Biochemistry Core, ..
  56. Diversity in Heme Protein Structure and Function
    THOMAS LEWIS POULOS; Fiscal Year: 2013
    ..A new crystal structure of a peroxidase-cytochrome c complex has been solved which has provided a new system for probing inter-protein electron transfer. ..
  57. An unexpected role for elF4a3 in regulating GPx1 selenoprotein expression
    MICHAEL EVEREST BUDIMAN; Fiscal Year: 2010
    ..For example, when selenium are limiting, expression of phospholipid hydroperoxide glutathione peroxidase (PhGPx) in the rat liver is preserved in the expense of glutathione peroxidase 1 (GPx1) and other selenoproteins,..
  58. Prenatal Organochlorine Exposure and Male Reproduction
    PAM R FACTOR LITVAK; Fiscal Year: 2010
    ..will be assayed for organochlorine compounds, and for free thyroxine, thyroid stimulating hormone, and thyroid peroxidase antibodies...
  59. Gpx3 Targeting and Extracellular Oxidative Stress
    Raymond F Burk; Fiscal Year: 2012
    Extracellular glutathione peroxidase (Gpx3) is produced primarily by the proximal convoluted tubule (PCT) cells of the kidney. Gpx3 catabolizes H2O2 and other hydroperoxides outside cells using GSH as its reducing substrate...
  60. Effects of Hydrogen Peroxide on Substantia Nigra GABAergic Neuron Excitability
    Christian R Lee; Fiscal Year: 2010
    ..hydrogen peroxide, and more importantly, while enhancing endogenous hydrogen peroxide levels by inhibiting peroxidase enzymes, which will be verified using the fluorescent hydrogen peroxide-sensitive indicator, ..
  61. Separated Concerted Proton-Electron Transfer with Biomimetic Models of Peroxidase
    ALEXANDER RAY FOX; Fiscal Year: 2011
    ..Studies of these chemical model systems will provide important new insights into the functions and functioning of the full biological systems. ..
  62. Retrograde Tracers with Suicide Enzyme?Prodrug to Study Specific Neural Circuits
    Xinmin Simon Xie; Fiscal Year: 2010
    ..linked to a suicide enzyme such as nitroreductase (NTR), purine nucleoside phosphorylase (PNP), or horseradish peroxidase (HRP)...
    Sudhir Shah; Fiscal Year: 1993
    ..I plan to examine: 1. The specific activity of SOD, catalase and glutathione peroxidase in glomeruli, tubules and renal cortex in normal and in anti-Fx1A-treated rats. ii...
    Sampath Parthasarathy; Fiscal Year: 1999
    ..b>Peroxidase mediated oxidation of LDL may involve the generation of apoB-derived radicals which may initiate peroxidation of ..
    Henry Kaplan; Fiscal Year: 1980
    ..At the same time ADR inhibits glutathione peroxidase, the mjaor defense against lipid peroxides...
  66. Biochemistry of Chorion Hardening in Mosquitoes
    Jianyong Li; Fiscal Year: 2005
    ..that two interrelated biochemical events, Phenoloxidase/dopa decarboxylase- catalyzed chorion melanization and peroxidase-mediated chorion protein crosslinking are involved in the overall chorion hardening in A. aegypti...
    Julie Andersen; Fiscal Year: 1999
    ..superoxide dismutase reduces superoxide to hydrogen peroxide, which is in turn reduced by either glutathione peroxidase or catalase to H20. Iron, in turn, is normally bound to ferritin, the major iron storage molecule in the brain...
  68. Selenium, Glutathione Peroxidase-1, and Homocysteine-induced Cardiac Remodeling
    Jacob Joseph; Fiscal Year: 2009
    ..fibrosis, since a major cellular defense against oxidant stress is the selenium requiring enzyme glutathione peroxidase- 1 (GPx-1)...
    EDWIN THOMAS; Fiscal Year: 1992
    ..Stimulated leukocytes in the salivary glands, oral mucosa, and saliva may also produce H2O2 and secrete peroxidase enzymes...
    ..H202 determination was made with the dichlorophenolindophenol (DCPIP) method, which involves the horseradish peroxidase-catalyzed oxidation of DCPIP by H202...
    Arlan Richardson; Fiscal Year: 2001
    ..that show reduced expression of either Mn-SOD (Sod2+/-) or both Mn-SOD and the selenium-dependent glutathione peroxidase (Sod2+/-XGpx1+/-F1) will be used to test the following hypothesis: An imbalance between prooxidants and ..
    Raymond Burk; Fiscal Year: 1992
    ..Defenses against oxidant stress such as Se (acting through glutathione peroxidase), vitamin E, glutathione, and taurine would be expected to protect the myocardium...
    SEYMOUR KLEBANOFF; Fiscal Year: 1999
    ..the toxicity of H2O2 is increased considerably by the addition of peroxidase and a halide and this antimicrobial system appears to play a role in certain phagocytes (e.g...
  74. Peroxidase-Based Toxicity In Hypereosinophilic States.'
    Arne Slungaard; Fiscal Year: 2006
    ..Endocardial and myocardial deposition of EO specific granule proteins, of which eosinophil peroxidase (EPO) is the most abundant, is proposed to mediate cardiotoxicity in EHD...
  75. GPx-3, Vascular Oxidant Stress, and Thrombosis
    Joseph Loscalzo; Fiscal Year: 2006
    ..Extracellular antioxidant enzymes, including extracellular superoxide dismutase and plasma glutathione peroxidase, limit the inactivation of endothelial nitric oxide by reactive oxygen species...