glutathione peroxidase

Summary

Summary: An enzyme catalyzing the oxidation of 2 moles of glutathione in the presence of hydrogen peroxide to yield oxidized glutathione and water. EC 1.11.1.9.

Top Publications

  1. ncbi Antioxidant enzymes and human diseases
    J M Mates
    Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Malaga, Spain
    Clin Biochem 32:595-603. 1999
  2. ncbi Glutathione peroxidase activity in selenium-deficient rat liver
    R A Lawrence
    Biochem Biophys Res Commun 71:952-8. 1976
  3. pmc Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice
    K K Ohlemiller
    Fay and Carl Simons Center for the Biology of Hearing and Deafness, Central Institute for the Deaf, St Louis, MO 63110, USA
    J Assoc Res Otolaryngol 1:243-54. 2000
  4. pmc An Arabidopsis glutathione peroxidase functions as both a redox transducer and a scavenger in abscisic acid and drought stress responses
    Yuchen Miao
    Henan Key Laboratory of Plant Stress Biology, Department of Biology, Henan University, Kaifeng 475001, China
    Plant Cell 18:2749-66. 2006
  5. ncbi Role of selenium on calcium signaling and oxidative stress-induced molecular pathways in epilepsy
    Mustafa Naziroglu
    Department of Biophysics, Medical Faculty, Suleyman Demirel University, Morfoloji Binasi, Cunur, 32260 Isparta, Turkey
    Neurochem Res 34:2181-91. 2009
  6. ncbi Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury
    P J Crack
    Centre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Melbourne, Victoria, Australia
    J Neurochem 78:1389-99. 2001
  7. ncbi Cellular glutathione peroxidase in human brain: cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson's disease and dementia with Lewy bodies
    John H T Power
    Department of Human Physiology, School of Medicine, Flinders University of South Australia, Adelaide, SA, 5042, Australia
    Acta Neuropathol 117:63-73. 2009
  8. ncbi Associations between GPX1 Pro198Leu polymorphism, erythrocyte GPX activity, alcohol consumption and breast cancer risk in a prospective cohort study
    Gitte Ravn-Haren
    Department of Toxicology and Risk Assessment, Danish Institute for Food and Veterinary Research, Søborg, Denmark
    Carcinogenesis 27:820-5. 2006
  9. ncbi Glutathione peroxidases in different stages of carcinogenesis
    Regina Brigelius-Flohe
    Department Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Biochim Biophys Acta 1790:1555-68. 2009
  10. pmc Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity
    Yiqiang Zhang
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78245, USA
    J Gerontol A Biol Sci Med Sci 64:1212-20. 2009

Detail Information

Publications390 found, 100 shown here

  1. ncbi Antioxidant enzymes and human diseases
    J M Mates
    Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Malaga, Spain
    Clin Biochem 32:595-603. 1999
    To describe the importance of the antioxidant enzymes superoxide dismutase, glutathione peroxidase, and catalase working together in human cells against toxic reactive oxygen species, their relationship with several pathophysiologic ..
  2. ncbi Glutathione peroxidase activity in selenium-deficient rat liver
    R A Lawrence
    Biochem Biophys Res Commun 71:952-8. 1976
  3. pmc Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice
    K K Ohlemiller
    Fay and Carl Simons Center for the Biology of Hearing and Deafness, Central Institute for the Deaf, St Louis, MO 63110, USA
    J Assoc Res Otolaryngol 1:243-54. 2000
    ..We examined whether genetically based deficiency of cellular glutathione peroxidase, a major antioxidant enzyme, increases noise-induced hearing loss in mice...
  4. pmc An Arabidopsis glutathione peroxidase functions as both a redox transducer and a scavenger in abscisic acid and drought stress responses
    Yuchen Miao
    Henan Key Laboratory of Plant Stress Biology, Department of Biology, Henan University, Kaifeng 475001, China
    Plant Cell 18:2749-66. 2006
    ....
  5. ncbi Role of selenium on calcium signaling and oxidative stress-induced molecular pathways in epilepsy
    Mustafa Naziroglu
    Department of Biophysics, Medical Faculty, Suleyman Demirel University, Morfoloji Binasi, Cunur, 32260 Isparta, Turkey
    Neurochem Res 34:2181-91. 2009
    ..drug therapies such as valproic acid, deplete the total body selenium level and selenium-dependent glutathione peroxidase (GSH-Px) activity although therapy with a new epileptic drug, topiramate, activated GSH-Px activity in ..
  6. ncbi Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury
    P J Crack
    Centre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Melbourne, Victoria, Australia
    J Neurochem 78:1389-99. 2001
    b>Glutathione peroxidase is an antioxidant enzyme that is involved in the control of cellular oxidative state...
  7. ncbi Cellular glutathione peroxidase in human brain: cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson's disease and dementia with Lewy bodies
    John H T Power
    Department of Human Physiology, School of Medicine, Flinders University of South Australia, Adelaide, SA, 5042, Australia
    Acta Neuropathol 117:63-73. 2009
    b>Glutathione peroxidase (GPx-1) is regarded as one of the mammalian cell's main antioxidant enzymes inactivating hydrogen peroxide and protecting against oxidative stress...
  8. ncbi Associations between GPX1 Pro198Leu polymorphism, erythrocyte GPX activity, alcohol consumption and breast cancer risk in a prospective cohort study
    Gitte Ravn-Haren
    Department of Toxicology and Risk Assessment, Danish Institute for Food and Veterinary Research, Søborg, Denmark
    Carcinogenesis 27:820-5. 2006
    ..The purpose of the present nested case-control study was to determine whether GPX1 Pro198Leu and glutathione peroxidase (GPX) activity in prospectively collected blood samples are associated with breast cancer risk among ..
  9. ncbi Glutathione peroxidases in different stages of carcinogenesis
    Regina Brigelius-Flohe
    Department Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Biochim Biophys Acta 1790:1555-68. 2009
    ..Metastasis, but also apoptosis, is inhibited by all GPxs. GPx-mediated regulation of COX/LOX activities may be relevant to early stages of inflammation-mediated carcinogenesis...
  10. pmc Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity
    Yiqiang Zhang
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78245, USA
    J Gerontol A Biol Sci Med Sci 64:1212-20. 2009
    ..deficiency in two mitochondrial-localized antioxidant enzymes, Mn superoxide dismutase (MnSOD) and glutathione peroxidase-1 (Gpx-1)...
  11. ncbi Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease
    Stefan Blankenberg
    Department of Medicine II, Johannes Gutenberg University, Mainz, Germany
    N Engl J Med 349:1605-13. 2003
    Cellular antioxidant enzymes such as glutathione peroxidase 1 and superoxide dismutase have a central role in the control of reactive oxygen species...
  12. pmc Genetic polymorphisms of superoxide dismutases, catalase, and glutathione peroxidase in age-related cataract
    Yi Zhang
    Eye Hospital, The First Affiliated Hospital, Harbin Medical University, Harbin, China
    Mol Vis 17:2325-32. 2011
    ..Therefore, we investigate the possible association between polymorphisms of Cu/Zn superoxide dismutase (SOD1), catalase (CAT), and glutathione peroxidase (GPX) genes and age -related cataract development.
  13. pmc Catalase and glutathione peroxidase mimics
    Brian J Day
    Department of Medicine, National Jewish Health, Departments of Medicine, Immunology and Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Biochem Pharmacol 77:285-96. 2009
    ..This review will focus on recent development of catalytic scavengers of peroxides and their potential use as therapeutic agents for pulmonary, cardiovascular, neurodegenerative and inflammatory disorders...
  14. pmc Gene x Gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control study
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    BMC Cancer 6:217. 2006
    ..Polymorphisms in the manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPX-1) genes have been proposed as low penetrance alleles, and have not been clearly associated with ..
  15. ncbi The glutathione peroxidases
    J R Arthur
    Rowett Research Institute, Aberdeen, Scotland, United Kingdom
    Cell Mol Life Sci 57:1825-35. 2000
    ..Additionally, cellular glutathione peroxidase knockout mice have been used to investigate the functions of this protein...
  16. pmc Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma
    Caitlyn W Barrett
    Department of Medicine, Division of Gastroenterology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cancer Res 73:1245-55. 2013
    ..The glutathione peroxidase GPX3 is the only extracellular member of this family, suggesting it may defend cells against ROS in the ..
  17. ncbi Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat diet
    Judy B de Haan
    Oxidative Stress Group, Baker Heart Research Institute, Melbourne, Australia
    J Lipid Res 47:1157-67. 2006
    Oxidative stress is thought to contribute to the initiation and progression of atherosclerosis. As glutathione peroxidase-1 (Gpx1) is an antioxidant enzyme that detoxifies lipid hydroperoxides, we tested the impact of Gpx1 deficiency on ..
  18. ncbi A comparison of thiol peroxidase mechanisms
    Leopold Flohe
    Otto von Guericke Universität and MOLISA GmbH, Magdeburg, Germany
    Antioxid Redox Signal 15:763-80. 2011
    ..Diversity combined with structural variability predestines thiol peroxidases for redox regulation via ROOH sensing and direct or indirect transduction of oxidant signals to specific protein targets...
  19. pmc Antagonistic interactions between yeast [PSI(+)] and [URE3] prions and curing of [URE3] by Hsp70 protein chaperone Ssa1p but not by Ssa2p
    Christine Schwimmer
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0851, USA
    Mol Cell Biol 22:3590-8. 2002
    ..Our data also suggest that differences in how [PSI(+)] and [URE3] interact with Hsp104 and Hsp70 may contribute to their antagonistic interactions...
  20. pmc Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities
    Edith Lubos
    Department of Medicine II, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    Antioxid Redox Signal 15:1957-97. 2011
    ..Left unchecked, these reactive species can cause oxidative damage to DNA, proteins, and membrane lipids. Glutathione peroxidase-1 (GPx-1) is an intracellular antioxidant enzyme that enzymatically reduces hydrogen peroxide to water to ..
  21. ncbi Glutathione peroxidases and redox-regulated transcription factors
    Regina Brigelius-Flohe
    German Institute of Human Nutrition, Potsdam Rehbrucke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Biol Chem 387:1329-35. 2006
    ..Redox sensing and redox regulation of metabolic events have become attractive paradigms to unravel the specific and in part still enigmatic roles of GPxs...
  22. ncbi Oxidative stress caused by inactivation of glutathione peroxidase and adaptive responses
    Yasuhide Miyamoto
    Department of Biochemistry, Osaka University Medical School, Osaka, 565 0871, Japan
    Biol Chem 384:567-74. 2003
    ..This review focuses on oxidative stress caused by the inactivation of glutathione peroxidase (GPx), a major peroxide scavenging enzyme...
  23. ncbi Daily rhythm of glutathione peroxidase activity, lipid peroxidation and glutathione levels in tissues of pinealectomized rats
    Giyasettin Baydas
    Department of Physiology, College of Medicine, Firat University, Elazig 213119, Turkey
    Neurosci Lett 323:195-8. 2002
    ..In the present study, we aimed to investigate the endogenous rhythm of antioxidant enzyme glutathione peroxidase (GSH-Px) activity, oxidized glutathione (GSSG) and lipid peroxidation levels in tissues of pinealectomized ..
  24. ncbi Intracellular pro-oxidant activity of melatonin deprives U937 cells of reduced glutathione without affecting glutathione peroxidase activity
    Maria Cristina Albertini
    Istituto di Chimica Biologica G Fornaini, Via Saffi 2, 61029 Urbino, Italy
    Ann N Y Acad Sci 1091:10-6. 2006
    ..The activity of glutathione peroxidase is not modified by melatonin treatment as it does occur in other experimental models.
  25. pmc Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue
    Christine J Weydert
    Department of Molecular Physiology and Biophysics, The University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Nat Protoc 5:51-66. 2010
    ..are described to measure the antioxidant enzyme activity of superoxide dismutase (SOD), catalase and glutathione peroxidase. The SODs convert superoxide radical into hydrogen peroxide and molecular oxygen, whereas the catalase and ..
  26. ncbi Methods of assessment of selenium status in humans: a systematic review
    Kate Ashton
    School of Medicine, Health Policy and Practice, The University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 89:2025S-2039S. 2009
    ..To understand the effect of selenium intake on health, it is important to identify sensitive and population-specific biomarkers of selenium status...
  27. ncbi GPX1 Pro198Leu polymorphism and breast cancer risk: a meta-analysis
    Jia Hu
    Department of Oncology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, People s Republic of China
    Breast Cancer Res Treat 124:425-31. 2010
    A genetic polymorphism at codon 198 in the human glutathione peroxidase 1 gene was reported to be associated with several cancers. However, this relationship remains controversial, especially in breast cancer...
  28. ncbi A thiol peroxidase is an H2O2 receptor and redox-transducer in gene activation
    Agnes Delaunay
    Laboratoire Stress Oxydants et Cancers, SBGM, DBJC, CEA Saclay, 91191 Gif sur Yvette, Cedex, France
    Cell 111:471-81. 2002
    ..We show that Yap1 is not directly oxidized by hydroperoxide. We identified the glutathione peroxidase (GPx)-like enzyme Gpx3 as a second component of the pathway, serving the role of sensor and transducer of ..
  29. ncbi Protective effect of caffeic acid phenethyl ester (CAPE) administration on cisplatin-induced oxidative damage to liver in rat
    Mustafa Iraz
    Inonu University, Faculty of Medicine, Department of Pharmacology, Malatya, Turkey
    Cell Biochem Funct 24:357-61. 2006
    ..Liver tissue was removed to study the activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), myeloperoxidase (MPO), xanthine oxidase (XO), adenosine deaminase (ADA), and the levels of ..
  30. ncbi Glutathione peroxidase 1 activity dictates the sensitivity of glioblastoma cells to oxidative stress
    Ivana Dokic
    INSERM U701, German Cancer Research Centre, Program Infection and Cancer, INF 242, Heidelberg, Germany
    Glia 60:1785-800. 2012
    ..species (ROS/RNS) detoxification mechanisms include superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx)...
  31. ncbi Aorta of ApoE-deficient mice responds to atherogenic stimuli by a prelesional increase and subsequent decrease in the expression of antioxidant enzymes
    Peter A C 't Hoen
    Division of Biopharmaceutics of the Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Circ Res 93:262-9. 2003
    ..The expression of catalase-1 and various isoforms of superoxide dismutase, glutathione peroxidase, and glutathione S-transferase alpha was significantly increased in the aortic arch, but not in the ..
  32. pmc Aging decreases expression and activity of glutathione peroxidase-1 in human endothelial progenitor cells
    Tongrong He
    Department of Anesthesiology and Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Microvasc Res 78:447-52. 2009
    ..In EPCs of old subjects, the levels of glutathione peroxidase-1 (GPX1) protein and enzymatic activity were significantly reduced...
  33. pmc Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply
    Susanne Krehl
    Department of Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Carcinogenesis 33:620-8. 2012
    ..Similarly, SFN requires selenium but not GPx2 for being protective...
  34. ncbi Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI
    F F Chu
    Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, California 91010
    J Biol Chem 268:2571-6. 1993
    We have characterized a new selenium-dependent glutathione peroxidase, GSHPx-GI, by expressing a GSHPx-GI cDNA isolated from human hepatoma HepG2 cells in human mammary carcinoma MCF-7 cells, which have virtually undetectable expression ..
  35. ncbi Regulation of antioxidant enzymes: a significant role for melatonin
    Carmen Rodriguez
    Departamento de Morfologia y Biologia Celular, Facultad de Medicina, c Julian Claveria, Oviedo, Spain
    J Pineal Res 36:1-9. 2004
    ..which document the influence of melatonin on the activity and expression of the antioxidative enzymes glutathione peroxidase, superoxide dismutases and catalase both under physiological and under conditions of elevated oxidative ..
  36. ncbi Mice with combined disruption of Gpx1 and Gpx2 genes have colitis
    R S Esworthy
    Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Am J Physiol Gastrointest Liver Physiol 281:G848-55. 2001
    b>Glutathione peroxidase (GPX)-1 and gastrointestinal (GI) epithelium-specific GPX (GPX-GI), encoded by Gpx1 and Gpx2, provide most GPX activity in GI epithelium...
  37. ncbi A yeast-based assay to isolate drugs active against mammalian prions
    Stephane Bach
    CNRS, Station Biologique, UPS2682, Place G Teissier, 29680 Roscoff, Bretagne, France
    Methods 39:72-7. 2006
    ..These results strongly argue in favor of common prion controlling mechanisms conserved in eukaryotes, thus validating our yeast-based assay and also the use of budding yeast to identify antiprion compounds and to study the prion world...
  38. ncbi Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium supplementation in a gender-specific manner (the SELGEN study)
    Catherine Méplan
    Institute for Cell and Molecular Biosciences and Human Nutrition Research Centre, The Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH UK
    FASEB J 21:3063-74. 2007
    ..Plasma Se, SePP, and glutathione peroxidase 3 (GPx3) levels increased with supplementation...
  39. ncbi Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia
    Y S Ho
    Institute of Chemical Toxicology and Department of Biochemistry, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 272:16644-51. 1997
    b>Glutathione peroxidase, a selenium-containing enzyme, is believed to protect cells from the toxicity of hydroperoxides...
  40. ncbi Controlled elimination of intracellular H(2)O(2): regulation of peroxiredoxin, catalase, and glutathione peroxidase via post-translational modification
    Sue Goo Rhee
    Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Antioxid Redox Signal 7:619-26. 2005
    ..Similarily, GPx1 is activated by c-Abl- and Arg-mediated phosphorylation. The tyrosine phosphorylation is critical for ubiquitination-dependent degradation of catalase...
  41. ncbi Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide
    J B de Haan
    Molecular Genetics and Development Group, Institute of Reproduction and Development, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia
    J Biol Chem 273:22528-36. 1998
    ....
  42. ncbi Glutathione peroxidase-deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: importance of an intracellular oxidant stress
    H Jaeschke
    Department of Pharmacology, Pharmacia and Upjohn, Inc, Kalamazoo, MI, USA
    Hepatology 29:443-50. 1999
    ..In glutathione peroxidase-deficient mice (Gpx1(-/-)), Gal/ET or Gal/tumor necrosis factor alpha (TNF-alpha) caused more severe ..
  43. ncbi Plasma lipid peroxidation and antioxidant levels in patients with rheumatoid arthritis
    Ayhan Kamanli
    Department of Physical Medicine and Rehabilitation, Medical Faculty, Firat University, Elazig, Turkey
    Cell Biochem Funct 22:53-7. 2004
    ..The aim of this study was to investigate plasma concentrations of vitamin E, beta-carotene, activities of glutathione peroxidase (GSH-Px) and catalase, levels of lipid peroxidation (MDA) and reduced glutathione (GSH) in 36 patients ..
  44. ncbi Glutathione peroxidase family - an evolutionary overview
    Rogerio Margis
    Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    FEBS J 275:3959-70. 2008
    ..Some glutathione peroxidase isozymes have a selenium-dependent glutathione peroxidase activity and present a selenocysteine encoded by ..
  45. ncbi Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4)
    G Spanier
    Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany
    J Physiol Pharmacol 60:111-6. 2009
    ..are the predominant producers of superoxide in the vasculature, whereas superoxide dismutase (SOD) and glutathione peroxidase 1 (GPx1) are the major enzymes responsible for the inactivation of superoxide and hydrogen peroxide, ..
  46. ncbi Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
    S Lenzen
    Institute of Clinical Biochemistry, Hannover Medical School, Germany
    Free Radic Biol Med 20:463-6. 1996
    ..Northern blot hybridization technique, gene expression of superoxide dismutase (SOD), catalase, and glutathione peroxidase was studied in pancreatic islets and for comparison in various other mouse tissues (liver, kidney, brain, ..
  47. pmc A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity
    Yoshito Tanaka
    Pacific Northwest Research Institute and the Department of Medicine, University of Washington, Seattle, WA, 98122, USA
    Proc Natl Acad Sci U S A 99:12363-8. 2002
    ..shown to increase intracellular oxidant load in islets, nor have the effects of increasing or inhibiting glutathione peroxidase (GPx) activity on islet resistance to sugar-induced oxidant stress been studied...
  48. ncbi Lack of the antioxidant enzyme glutathione peroxidase-1 accelerates atherosclerosis in diabetic apolipoprotein E-deficient mice
    Paul Lewis
    Oxidative Stress Group, JDRF Diabetes and Metabolism Division, Baker Heart Research Institute, PO Box 6492, St Kilda Rd Central, Melbourne, VIC 8008, Australia
    Circulation 115:2178-87. 2007
    Recent clinical studies have suggested a major protective role for the antioxidant enzyme glutathione peroxidase-1 (GPx1) in diabetes-associated atherosclerosis...
  49. ncbi Aberrant expression of selenoproteins in the progression of colorectal cancer
    Yoshiyuki Murawaki
    Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University, Japan
    Cancer Lett 259:218-30. 2008
    ..cancer, the aim of the present study is to clarify the role of antioxidant seleonoproteins including glutathione peroxidase (GPx), thioredoxin reductase (TXR) and selenoprotein P (SePP), and the effect of oxidative stress on the ..
  50. ncbi The effect of whole-body cryostimulation on the prooxidant-antioxidant balance in blood of elite kayakers after training
    Alina Wozniak
    Collegium Medicum, Nicolaus Copernicus University, Department and Clinic of Neurosurgery and Neurotraumatology, Karłowicza 24, 85 092, Bydgoszcz, Poland
    Eur J Appl Physiol 101:533-7. 2007
    ..001) and glutathione peroxidase (GPx) by 68% (P<0...
  51. ncbi Chronic oxidative stress as a mechanism for glucose toxicity of the beta cell in type 2 diabetes
    R Robertson
    Pacific Northwest Research Institute, Seattle, WA, USA
    Cell Biochem Biophys 48:139-46. 2007
    ..These observations suggest that the ancillary treatment with antioxidants may improve outcomes of standard therapy of type 2 diabetes in humans...
  52. ncbi Cytosolic glutathione peroxidase from liver of pacu (Piaractus mesopotamicus), a hypoxia-tolerant fish of the Pantanal
    V L F Cunha Bastos
    Department of Biochemistry, UERJ, Av Professor Manuel de Abreu, 444, Rio de Janeiro, RJ, Brazil
    Biochimie 89:1332-42. 2007
    ..Accordingly, we found that cytosol from liver of pacu has the highest antioxidant glutathione peroxidase activity so far reported for fish and murine species...
  53. pmc Nucleotide exchange factors for Hsp70s are required for [URE3] prion propagation in Saccharomyces cerevisiae
    Dmitry Kryndushkin
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0830, USA
    Mol Biol Cell 18:2149-54. 2007
    ..Sse1p and Fes1p are nucleotide exchange factors for Ssa1p. Interestingly, deletion of either SSE1 or FES1 completely blocked [URE3] propagation. In addition, deletion of SSE1 also interfered with [PSI(+)] propagation...
  54. ncbi Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genes
    Fong Fong Chu
    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA
    Cancer Res 64:962-8. 2004
    Two glutathione peroxidase (GPX) isozymes, GPX-1 and GPX-2 (GPX-GI), are the major enzymes that reduce hydroperoxides in intestinal epithelium...
  55. ncbi Epithelium-specific glutathione peroxidase, Gpx2, is involved in the prevention of intestinal inflammation in selenium-deficient mice
    R Steven Esworthy
    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010 3000, USA
    J Nutr 135:740-5. 2005
    ..The results show that a trace amount of Gpx2 is protective against ileocolitis, and Se-deficient young Gpx1(+/-)Gpx2(-/-) mice will develop pathology and symptoms similar to Se-adequate Gpx1(-/-)Gpx2(-/-) mice...
  56. ncbi Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium
    Ya Jun Hu
    Department of Human Nutrition, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Cancer Res 63:3347-51. 2003
    A role for allelic variation within the gene for the antioxidant selenoprotein glutathione peroxidase 1 (GPx-1) in the risk or etiology of breast cancer was investigated...
  57. pmc Scrambled prion domains form prions and amyloid
    Eric D Ross
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0830, USA
    Mol Cell Biol 24:7206-13. 2004
    ....
  58. ncbi Effects of estrogens and androgens on erythrocyte antioxidant superoxide dismutase, catalase and glutathione peroxidase activities during the menstrual cycle
    C Massafra
    Department of Obstetrics and Gynecology, University of Siena, Siena, Italy
    J Endocrinol 167:447-52. 2000
    ..changes in estrogens and androgens on the erythrocyte antioxidant superoxide dismutase, catalase and glutathione peroxidase enzyme activities during the menstrual cycle were investigated in healthy eumenorrheic women...
  59. pmc Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells
    Dunfa Peng
    Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA
    Gut 61:1250-60. 2012
    ..This study investigated the functions of glutathione peroxidase 7 (GPX7), frequently silenced in OAC, and its capacity in regulating ROS and its associated oxidative DNA ..
  60. pmc Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet
    Jiqu Xu
    Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan, PR China
    Lipids Health Dis 10:96. 2011
    ..The aim of this study was to determine the effect of rapeseed oil fortified with these micronutrients on the atherosclerosis risk factors in rats fed a high-fat diet...
  61. ncbi Whole-body cryostimulation in kayaker women: a study of the effect of cryogenic temperatures on oxidative stress after the exercise
    C Mila-Kierzenkowska
    Department of Medical Biology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
    J Sports Med Phys Fitness 49:201-7. 2009
    ..The aim of this study was to determine the effect of whole-body cryostimulation on the activity of selected antioxidant enzymes and the concentration of lipid peroxidation products in kayaker women in the course of training...
  62. pmc Eukaryotic initiation factor 4a3 is a selenium-regulated RNA-binding protein that selectively inhibits selenocysteine incorporation
    Michael E Budiman
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Mol Cell 35:479-89. 2009
    ..Our results support a model in which eIF4a3 links selenium status with differential selenoprotein expression...
  63. ncbi Associations between glutathione peroxidase-1 Pro198Leu polymorphism, selenium status, and DNA damage levels in obese women after consumption of Brazil nuts
    Cristiane Cominetti
    Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Science, University of Sao Paulo, Sao Paulo, Brazil
    Nutrition 27:891-6. 2011
    ..The Pro198Leu polymorphism at the glutathione peroxidase-1 (GPx1) gene is supposed to be functional...
  64. pmc Molecular consequences of genetic variations in the glutathione peroxidase 1 selenoenzyme
    Pin Zhuo
    Department of Pathology, University of Illinois at Chicago, Illinois 60612, USA
    Cancer Res 69:8183-90. 2009
    Accumulating data have implicated the selenium-containing cytosolic glutathione peroxidase, GPx-1, as a determinant of cancer risk and a mediator of the chemopreventive properties of selenium...
  65. ncbi Redox homeostasis, antioxidant defense, and methylglyoxal detoxification as markers for salt tolerance in Pokkali rice
    Hattem El-Shabrawi
    Plant Molecular Biology, International Centre for Genetic Engineering and Biotechnology ICGEB, Aruna Asaf Ali Marg, New Delhi, 110 067, India
    Protoplasma 245:85-96. 2010
    ..In addition, status of reactive oxygen species and oxidative DNA damage can serve as a quick and sensitive biomarker for screening against salt and other abiotic stresses in crop plants...
  66. pmc 12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases
    Marcus Conrad
    Helmholtz Center Munich, Institute of Clinical Molecular Biology and Tumor Genetics, Germany
    Proc Natl Acad Sci U S A 107:15774-9. 2010
    ..This study demonstrates that increases in cellular lipid peroxides, induced by disruption of glutathione peroxidase 4, induce cellular PTP oxidation and reduce the activity of PDGF receptor targeting PTPs...
  67. pmc The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old
    Mette Soerensen
    Danish Aging Research Center, Epidemiology, Institute of Public Health, University of Southern Denmark, J B Winsloews Vej 9B, 5000 Odense C, Denmark
    Mech Ageing Dev 130:308-14. 2009
    ..The rs4880 and rs1050450 SNPs in the manganese superoxide dismutase (MnSOD) and glutathione peroxidase 1 (GPX1) genes, respectively, are associated with age-related diseases and appear to affect the activities ..
  68. pmc Functional and physical interaction between the selenium-binding protein 1 (SBP1) and the glutathione peroxidase 1 selenoprotein
    Wenfeng Fang
    Department of Pathology, University of Illinois at Chicago, 60612, USA
    Carcinogenesis 31:1360-6. 2010
    ..Another selenium-containing protein, glutathione peroxidase 1 (GPX1), has been associated with cancer risk and development...
  69. ncbi Mechanism of protective effects of Danshen against iron overload-induced injury in mice
    Yonggang Gao
    Department of Pharmacology, School of Basic Medicine, Hebei Medical University, 326, Xinshi South Road, Shijiazhuang, 050091 Hebei, China
    J Ethnopharmacol 145:254-60. 2013
    ..Danshen (Salvia miltiorrhiza) has been widely prescribed in traditional folk medicine for treatment of hepatic and cardiovascular diseases in China and other Asian countries for several hundred years...
  70. ncbi Diphenyl ditelluride targets brain selenoproteins in vivo: inhibition of cerebral thioredoxin reductase and glutathione peroxidase in mice after acute exposure
    Bruna Comparsi
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil
    Mol Cell Biochem 370:173-82. 2012
    ..cerebral antioxidant enzymes (catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GR), glutathione peroxidase (GPx), and thioredoxin reductase (TrxR)...
  71. ncbi The involvement of Arabidopsis glutathione peroxidase 8 in the suppression of oxidative damage in the nucleus and cytosol
    Ahmed Gaber
    Department of Advanced Bioscience, Kinki University, 3327 204 Nakamachi, Nara, 631 8505 Japan
    Plant Cell Physiol 53:1596-606. 2012
    A family of eight genes with homology to mammalian glutathione peroxidase (GPX) isoenzymes, designated AtGPX1-AtGPX8, has been identified in Arabidopsis thaliana...
  72. pmc Selenium status highly regulates selenoprotein mRNA levels for only a subset of the selenoproteins in the selenoproteome
    Roger A Sunde
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Biosci Rep 29:329-38. 2009
    Gpx (glutathione peroxidase)-1 enzyme activity and mRNA levels decrease dramatically in Se (selenium) deficiency, whereas other selenoproteins are less affected by Se deficiency...
  73. ncbi Protective role of selenium against renal toxicity induced by cadmium in rats
    A S el-Sharaky
    Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, Egypt
    Toxicology 235:185-93. 2007
    ..a significant decrease in the antioxidant systems such as reduced glutathione levels and the activities of glutathione peroxidase (GPx) and thioredoxin reductase (TrxR)...
  74. ncbi Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death
    Alexander Seiler
    Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Marchioninistrasse 25, 81377 Munich, Germany
    Cell Metab 8:237-48. 2008
    ..oxidation of essential biomolecules, we now demonstrate that oxidative stress is sensed and transduced by glutathione peroxidase 4 (GPx4) into a-yet-unrecognized cell-death pathway...
  75. ncbi Antioxidant effect of trans-resveratrol in cultured human retinal pigment epithelial cells
    Adela Pintea
    Department of Chemistry and Biochemistry, University of Agricultural Sciences and Veterinary Medicine, Cluj Napoca, Romania
    J Ocul Pharmacol Ther 27:315-21. 2011
    ..The purpose of this study was to evaluate the potential protective effect of resveratrol against hydrogen peroxide induced oxidative stress in cultured human RPE cells...
  76. ncbi Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion
    Connie H Y Wong
    Centre for Functional Genomics and Human Disease, Monash Institute of Medical Research, Monash University, Victoria, Australia
    J Neurochem 107:241-52. 2008
    Mice deficient in the anti-oxidant enzyme glutathione peroxidase-1 (Gpx1) have a greater susceptibility to cerebral injury following a localized ischemic event...
  77. ncbi Salidroside promotes erythropoiesis and protects erythroblasts against oxidative stress by up-regulating glutathione peroxidase and thioredoxin
    Erin Wei Qian
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    J Ethnopharmacol 133:308-14. 2011
    ..Rhodiola rosea is commonly used in China and Tibet folk medicine for the treatment of high altitude sickness, anoxia and mountain malhypoxia...
  78. ncbi Oxidative stress markers in bipolar disorder: a meta-analysis
    Ana C Andreazza
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    J Affect Disord 111:135-44. 2008
    ..In the present investigation, we conducted a meta-analysis of studies that evaluated markers of oxidative stress in individuals with BD, as compared to healthy controls...
  79. ncbi Decreased selenium-binding protein 1 enhances glutathione peroxidase 1 activity and downregulates HIF-1α to promote hepatocellular carcinoma invasiveness
    Cheng Huang
    Liver Cancer Institute, Fudan University, Shanghai, China
    Clin Cancer Res 18:3042-53. 2012
    ..We aimed to characterize the role of selenium-binding protein 1 (SBP1) in hepatocellular carcinoma (HCC) invasiveness and underlying clinical significance...
  80. pmc Effect of short-term cryostimulation on antioxidative status and its clinical applications in humans
    Elzbieta Miller
    Rehabilitation Ward, III General Hospital in Lodz, Milionowa 14, Lodz, Poland
    Eur J Appl Physiol 112:1645-52. 2012
    ..001). It was concluded that expositions to extremely low temperatures use in cryostimulation improve the antioxidant capacity of organism...
  81. ncbi Deficiency of glutathione peroxidase-1 accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice
    Michael Torzewski
    Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, 55101 Mainz, Germany
    Arterioscler Thromb Vasc Biol 27:850-7. 2007
    We have recently demonstrated that activity of red blood cell glutathione peroxidase-1 is inversely associated with the risk of cardiovascular events in patients with coronary artery disease...
  82. ncbi Role of glutathione peroxidase in protecting mammalian spermatozoa from loss of motility caused by spontaneous lipid peroxidation
    J G Alvarez
    Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, 19104 6080
    Gamete Res 23:77-90. 1989
    ..The enhancement of lipid peroxidation, the rate of reaction of H2O2 with the cells, the activity of sperm glutathione peroxidase, and the endogenous glutathione content are highest in mouse sperm, intermediate in human sperm, and very ..
  83. ncbi Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
    P Klivenyi
    Neurology Service, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Neurosci 20:1-7. 2000
    b>Glutathione peroxidase (GSHPx) is a critical intracellular enzyme involved in detoxification of hydrogen peroxide (H(2)O(2)) to water...
  84. ncbi HIV-1 gp120-induced injury to the blood-brain barrier: role of metalloproteinases 2 and 9 and relationship to oxidative stress
    Jean Pierre Louboutin
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Neuropathol Exp Neurol 69:801-16. 2010
    ..Prior administration of rSV40 vectors carrying the antioxidant enzymes Cu/Zn superoxide dismutase or glutathione peroxidase protected from gp120-induced BBB damage...
  85. ncbi Antioxidant enzyme activities and oxidative stress in affective disorders
    M Erkan Ozcan
    Department of Psychiatry, Inonu University Medical School, Malatya, Turkey
    Int Clin Psychopharmacol 19:89-95. 2004
    ..For this purpose, we measured superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities, as well as malondialdehyde (MDA) and nitric oxide (NO) levels in ..
  86. ncbi Functional effects of a common single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene: interaction with sex
    Catherine Méplan
    Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle, United Kingdom
    Am J Clin Nutr 87:1019-27. 2008
    ..Selenium is present as selenocysteine in selenoproteins such as the glutathione peroxidases (GPx). Selenocysteine incorporation requires specific structures in the 3'untranslated region (3'UTR) of selenoprotein mRNAs...
  87. ncbi Effects of organic and inorganic selenium supplementation on selenoenzyme activity in blood lymphocytes, granulocytes, platelets and erythrocytes
    K M Brown
    Rowett Research Institute, Division of Micronutrient and Lipid Metabolism, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, U K
    Clin Sci (Lond) 98:593-9. 2000
    ..organic selenomethionine and inorganic sodium selenite (50 microg of Se daily for 28 days) in modulating glutathione peroxidase activities in blood cells from 45 healthy men and women, from a U.K. population...
  88. ncbi Antioxidant status in the serum of persons with intellectual disability and hypothyroidism: a pilot study
    Eli Carmeli
    Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Res Dev Disabil 29:431-8. 2008
    ..The following antioxidative defense were examined: superoxide dismutase (SOD), catalase, glutathione peroxidase (GSH-Px), and glutathione reductase (GR) as well as two biochemical parameters creatinine and albumin...
  89. ncbi Effectiveness of selenium supplements in a low-selenium area of China
    Yiming Xia
    Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing, China
    Am J Clin Nutr 81:829-34. 2005
    ..Although there is no evidence of selenium deficiency in the United States, people in many other areas of the world are selenium deficient, with the consequence that they are unable to express their selenoproteins fully...
  90. ncbi Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes
    Yoshimasa Nakamura
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    FEBS Lett 572:245-50. 2004
    ..of several Nrf2/ARE-dependent phase II enzyme genes, including gamma-glutamylcysteine synthetase, glutathione peroxidase, and hemeoxygenase-1...
  91. ncbi Inflammatory response and glutathione peroxidase in a model of stroke
    Nobuya Ishibashi
    Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, and Neurotoxicology Laboratories, Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    J Immunol 168:1926-33. 2002
    ..damage observed in transgenic mice overexpressing human antioxidant enzymes (particularly intracellular glutathione peroxidase) involves the modulation of inflammatory response as well as reduced sensitivity of neurons to cytotoxic ..
  92. ncbi Assessment of requirements for selenium and adequacy of selenium status: a review
    C D Thomson
    Department of Human Nutrition, University of Otago, Dunedin, New Zealand
    Eur J Clin Nutr 58:391-402. 2004
    ..From this evidence, attempts have been made to define levels of plasma selenium and dietary selenium intake, which could be used for the assessment of deficiency or adequacy of selenium status...
  93. ncbi Induction of oxidative stress by bisphenol A in the epididymal sperm of rats
    K C Chitra
    School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
    Toxicology 185:119-27. 2003
    ..The activities of superoxide dismutase, catalase, glutathione reductase and glutathione peroxidase were decreased while the levels of H(2)O(2) and lipid peroxidation increased significantly in the treated ..
  94. ncbi Catalytic mechanisms and specificities of glutathione peroxidases: variations of a basic scheme
    Stefano Toppo
    Department of Biological Chemistry, Viale G Colombo, 3, University of Padova, I 35121 Padova, Italy
    Biochim Biophys Acta 1790:1486-500. 2009
    ..Heterodimer formation of yeast GPx with a transcription factor is discussed as paradigm of a redox sensing that might also be valid in vertebrates...
  95. pmc Importance of the Hsp70 ATPase domain in yeast prion propagation
    Harriet M Loovers
    Department of Biology, National University of Ireland, Maynooth, County Kildare, Ireland
    Genetics 175:621-30. 2007
    ..Analysis of the effects of Hsp70 mutants upon propagation of a second yeast prion [URE3] further classifies these mutants as having general or prion-specific inhibitory properties...
  96. ncbi Is the prion domain of soluble Ure2p unstructured?
    Michael M Pierce
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892 0830, USA
    Biochemistry 44:321-8. 2005
    ..These results suggest that the N-terminal prion domain is unstructured in the soluble protein and does not have a specific interaction with the C-terminus...
  97. pmc Increased expression of glutathione peroxidase 4 strongly protects retina from oxidative damage
    Lili Lu
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    Antioxid Redox Signal 11:715-24. 2009
    ..In contrast, RPE cells with increased expression of glutathione peroxidase 1 (Gpx1) or Gpx4 did not show an increase in constitutive oxidative damage...
  98. pmc Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children
    Barbara Voetsch
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Stroke 38:41-9. 2007
    Plasma glutathione peroxidase (GPx-3)-deficiency increases extracellular oxidant stress, decreases bioavailable nitric oxide, and promotes platelet activation...
  99. ncbi A probable causative factor for an old problem: selenium and glutathione peroxidase appear to play important roles in epilepsy pathogenesis
    Mahmoud Reza Ashrafi
    Children s Medical Center, Department of Pediatric Neurology, School of Medicine, Medical Sciences University of Tehran, Tehran, Iran
    Epilepsia 48:1750-5. 2007
    ..Se) and selenoproteins against oxidative damage and the ability to promote neuronal cell survival, we compared serum selenium level and red blood cell Glutathione peroxidase activity (RBC GPx) between epileptic and healthy children.
  100. ncbi Oxidative stress and antioxidant status in non-metastatic prostate cancer and benign prostatic hyperplasia
    Ahmet Aydin
    Gulhane Military Medical Academy, Department of Toxicology, 06018 Etlik, Ankara, Turkey
    Clin Biochem 39:176-9. 2006
    ..We undertook the present study to investigate the possible alteration of oxidant/antioxidant status in the circulation of patients with prostate cancer and benign prostatic hyperplasia...
  101. ncbi Selenium and high dose vitamin E administration protects cisplatin-induced oxidative damage to renal, liver and lens tissues in rats
    Mustafa Naziroglu
    Department of Physiology, Veterinary Faculty, Firat University, TR 23119, Elazig, Turkey
    Toxicology 195:221-30. 2004
    ..b>Glutathione peroxidase (GSH-Px), vitamin E and beta-carotene levels in the kidney, lens and liver, vitamin A and reduced ..

Research Grants66

  1. Arsenic Trioxide and Acute Myeloid Leukemia
    Yongkui Jing; Fiscal Year: 2012
    ..ROS generated as a byproduct of mitochondrial respiration are detoxified by glutathione-enzymes, glutathione peroxidase (GPx), glutathione-s-transferase ? (GST?) and glutathione reductase (GR)...
  2. The Effects of PP2A on TNF Signaling and Smoke-Induced Lung Injury
    Robert F Foronjy; Fiscal Year: 2013
    ..Further studies in our laboratory demonstrate that the transgenic expression of human SOD1 and glutathione peroxidase-1 (GPX1) decreases JNK activation and AP-1 signaling within the lungs of mice...
  3. Targeted investigation of tissue specific oxidative stress in the etiology of ALS
    Holly Van Remmen; Fiscal Year: 2013
    ..lipid hydroperoxides, a conditional knockout mouse carrying floxed alleles for phospholipid hydroperoxide glutathione peroxidase (Gpx4flfl mice). Gpx4 plays a critical role in protecting membranes by removal of lipid hydroperoxides...
  4. Timing of Exposure to Selenium and Isoflavones and Prostate Cancer Prevention
    EDWIN DOUGLAS LEPHART; Fiscal Year: 2010
    ..Se-dependent glutathione peroxidase and 5alpha-reductase activities will be assayed. AR and NF-:B activation will be determined by EMSA...
  5. Molecular Epidemiology of Chronic Liver Diseases
    Manal Hassan; Fiscal Year: 2009
    ..e., catalase, glutathione peroxidase, superoxide dismutases, TNF- alpha, and TGF beta1, IL-11, COX2) and genes of DNA repair (i.e...
  6. Identification of small molecule inhibitors of protein disulfide isomerase
    ROBERT C FLAUMENHAFT; Fiscal Year: 2012
    ..using a fluorescence-based assay of insulin aggregation, remove non-specific oxidase inhibitors using a glutathione peroxidase assay, and determine the specificity of inhibitors using alternative oxidoreductases, including ERp5, ..
  7. Respiratory and Metabolic Adaptation to Hypoxia
    Paul T Schumacker; Fiscal Year: 2013
    ..We hypothesize that Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx) functions as a signal transduction messenger in the ROS-HIF-1a pathway, transmitting the hypoxia-..
  8. Mechanistic Studies of Alkyl Hydroperoxide Reductase and Related Redox Proteins
    Leslie B Poole; Fiscal Year: 2013
    ..Catalase and glutathione peroxidase have long been viewed as the major enzymes degrading peroxide in cells, however, over the past few years, ..
  9. Mitochondrial Proteins in Parkinson's Disease
    J Timothy Greenamyre; Fiscal Year: 2013
    ..Hastings (Project 4) will study the roles of mitochondrial selenoproteins, such as glutathione peroxidase 4 and thioredoxin reductase 2, in neurodegeneration in PD...
  10. Biological Mechanisms of Arterial Stiffening With Age and Estrogen Deficiency
    KERRIE MOREAU; Fiscal Year: 2010
    ..g., NADPH) and antioxidant (e.g., glutathione peroxidase) enzymes, vasoconstrictors (endothelin- 1), and estrogen receptor alpha (ERalpha)...
  11. PATHOGENIC MECHANISMS OF CUTANEOUS LEISHMANIASIS
    Lynn Soong; Fiscal Year: 2012
    ..their contributions, we will use mice deficient in the oxidative stress pathways (NADPH oxidase, glutathione peroxidase, and superoxide dismutase)...
  12. Antioxidative role of GPX1 in transgenic mice.
    XINGEN LEI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cellular glutathione peroxidase-1 (GPX1) is the first identified selenium-dependent protein and a major intracellular antioxidant enzyme in mammals...
  13. Molecular Pathobiology of Barrett's Tumorigenesis
    Wael El-Rifai; Fiscal Year: 2013
    ..Using integrated analysis approaches, we have identified silencing of glutathione peroxidase 7 (GPX7) in two-thirds of BACs. GPX7 is a recently identified member of the GPX family...
  14. Oxidant Mechanisms in Neonatal Brain Injury
    Donna M Ferriero; Fiscal Year: 2013
    ..regulated by H2O2 to generate a cytoprotective response through the use of HIF conditional knockouts and glutathione peroxidase transgenics and knockouts...
  15. ADENOSINE AND ANTIOXIDANT ENZYMES
    Vickram Ramkumar; Fiscal Year: 1999
    ..of the cell from free radicals and comprises enzymes such as superoxide dismutase (SOD), catalase CAT), glutathione peroxidase (GSH...
  16. Selenium Colorectal Cancer Chemoprevention Trials
    PATRICIA ANN THOMPSON; Fiscal Year: 2013
    ..a mechanism for Se-related T2D in human is obscure, animal studies suggest that chronic activation of glutathione peroxidase 1 (GPX1), a potent anti-oxidant selenoprotein, may lead to the development of hyperinsulinemia, ..
  17. Cardiovascular Disease Biomarkers and Mediation of Hormone Therapy Effects
    Ross L Prentice; Fiscal Year: 2012
    ..For CHD these are alpha-1-acid glycoprotein 1, thrombospondin 1, complement factor D preprotein, glutathione peroxidase 3, and insulin-like binding protein 1 (IGFBP1)...
  18. Redox Mechanisms of Chemoprevention in Lung by Selenium Supplementation
    ROBYN POERSCHKE; Fiscal Year: 2010
    ..antioxidant response element (ARE) genes, including the selenoproteins thioredoxin reductase 1 (TrxRI) and glutathione peroxidase 2 (GPx2)...
  19. Selenium as an adjuvant to imatinib therapy
    Alan Diamond; Fiscal Year: 2010
    ..has been shown that imatinab also inhibits the activating phosphorylation of the selenium-dependent enzyme glutathione peroxidase (GPx-1)...
  20. GPx-3 and Peroxide Flux in the Endothelial Cell
    Joseph Loscalzo; Fiscal Year: 2013
    ..The central hypothesis of this award is that glutathione peroxidase-3 (GPx-3) is a principal determinant of extracellular hydrogen peroxide flux from the endothelial cell, ..
  21. Peroxiredoxin 6 as an Anti-oxidant Enzyme
    Aron B Fisher; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This project will evaluate the properties of a novel glutathione peroxidase enzyme that is considerably enriched in lungs and plays an important role in lung antioxidant defense and lung surfactant ..
  22. Glutathione Peroxidase & Redox State in Atherosclerosis
    Francis Miller; Fiscal Year: 2009
    ..Glutathione (GSH) is the most abundant redox buffer in the cell. The cytosolic enzyme glutathione peroxidase-1 (GPx-1) protects the cell against oxidant stress by utilizing GSH to reduce hydrogen peroxide and lipid ..
  23. Modeling Prostate Tumorigenesis
    Sarki A Abdulkadir; Fiscal Year: 2012
    ..1 dysregulates the expression of pro- and anti-oxidant enzymes (including peroxiredoxin 6, glutathione peroxidase 3 and sulfhydryl oxidase 6) resulting in loss of protection against oxidative damage...
  24. Arterial Dysfunction: Basic and Clinical Mechanisms
    Thomas Michel; Fiscal Year: 2013
    ..J. Loscaizo leads Project 4, "Glutathione peroxidase-1, mitochondrial function, and endothelial phenotype", and also is Co-Director of the Redox Biochemistry ..
  25. An unexpected role for elF4a3 in regulating GPx1 selenoprotein expression
    MICHAEL EVEREST BUDIMAN; Fiscal Year: 2010
    ..For example, when selenium are limiting, expression of phospholipid hydroperoxide glutathione peroxidase (PhGPx) in the rat liver is preserved in the expense of glutathione peroxidase 1 (GPx1) and other ..
  26. Gpx3 Targeting and Extracellular Oxidative Stress
    Raymond F Burk; Fiscal Year: 2012
    Extracellular glutathione peroxidase (Gpx3) is produced primarily by the proximal convoluted tubule (PCT) cells of the kidney. Gpx3 catabolizes H2O2 and other hydroperoxides outside cells using GSH as its reducing substrate...
  27. Anemia in the Elderly: Pathogenesis
    Jeffrey S Friedman; Fiscal Year: 2010
    ..and red cell hexokinase activity;oxidative damage to erythrocytes will be assessed by estimating GSSG/GSH, glutathione peroxidase, carbonyl proteins, TEARS;exposure of phosphatidylserine on erythrocyte membranes will be documented...
  28. Toxicant, oxidative injury, dopamine & synuclein in PD
    KATHLEEN ANNE MAGUIRE ZEISS; Fiscal Year: 2011
    ..overexpress human wild type a-synuclein in dopaminergic cells (SYN+/+) on the background of glial depleted glutathione peroxidase 1 (GPX-/-) and an antioxidant promoter-reporter...
  29. OXIDANT MECHANISMS IN MEMBRANOUS NEPHROPATHY
    Sudhir Shah; Fiscal Year: 1993
    ..I plan to examine: 1. The specific activity of SOD, catalase and glutathione peroxidase in glomeruli, tubules and renal cortex in normal and in anti-Fx1A-treated rats. ii...
  30. EFFECTS OF ADRIAMYCIN AND BCNU ON GLUTATHIONE
    Henry Kaplan; Fiscal Year: 1980
    ..At the same time ADR inhibits glutathione peroxidase, the mjaor defense against lipid peroxides...
  31. LIPID PEROXIDATION IN COLORECTAL CANCER
    Manuela Gago Dominguez; Fiscal Year: 2009
    ..endothelial cell nitric oxide synthase (ecNOS), manganese superoxide dismutase (MnSOD), selenium-dependent glutathione peroxidase (GPX1), catalase (CAT), glutathione S- transferase A1 (GSTA1), glutathione S-transferase M1 (GSTM1), ..
  32. Metals in exhaled breath condensate as COPD biomarkers
    Antonio Mutti; Fiscal Year: 2005
    ..that some trace elements (Mn, Cu, Zn, Se, and Mo) are components of metalloproteins (superoxide dismutase, glutathione peroxidase, xanthine oxidase) known to modulate the response to toxic substances, possibly accounting for the limited ..
  33. ART PHARMACOKINETICS IN SEVERELY MALNOURISHED HIV-INFECTED CHILDREN
    Ericka Hayes; Fiscal Year: 2009
    ..in monocytes), antioxidant capacity (assessed by whole blood glutathione, red cell superoxide dismutase, glutathione peroxidase, and oxidized serum proteins), hepatic function and integrity (quantified by albumin, alanine transaminase ..
  34. Mitochondrial SOD & Breast Cancer Risk-Mechanism
    JAMES YAGER; Fiscal Year: 2003
    ..The activity of mitochondrial glutathione peroxidase and GSH/GSSL levels will also be determined...
  35. OXIDATION OF MACROMOLECULES IN SPINAL CORD INJURY
    Danxia Liu; Fiscal Year: 2001
    ..2. To apply free radical suppressors (superoxide dismutase and glutathione peroxidase), a nitric oxide synthase inhibitor (nitro-L-arginine), and an iron chelator (desferrioxamine) into the ..
  36. OXYGEN RADICAL-ENZYME SCAVENGING IN ONCHOCERCA
    Eric James; Fiscal Year: 1990
    ..This study will look at the presence of superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-Px) principally in mf but also in adult worms and third stage larvae (L3s) of Onchocerca cervicalis, ..
  37. TRANSGENIC MICE, AGING, CANCER, AND OXIDATIVE DAMAGE
    Arlan Richardson; Fiscal Year: 2001
    ..mice that show reduced expression of either Mn-SOD (Sod2+/-) or both Mn-SOD and the selenium-dependent glutathione peroxidase (Sod2+/-XGpx1+/-F1) will be used to test the following hypothesis: An imbalance between prooxidants and ..
  38. OXIDATIVE CELL INJURY: FIRST-EPISODE PSYCHOTIC PATIENTS
    Sahebarao Mahadik; Fiscal Year: 2002
    ..Activities of antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase) will be determined in red blood cells and in lymphocyte mitochondria...
  39. MODELS FOR EXPLORING FREE RADICAL DAMAGE
    Julie Andersen; Fiscal Year: 1999
    ..enzyme superoxide dismutase reduces superoxide to hydrogen peroxide, which is in turn reduced by either glutathione peroxidase or catalase to H20...
  40. OXIDATIVE DAMAGE TO CRYOPRESERVED SPERM
    BAYARD STOREY; Fiscal Year: 1992
    ..loss, lipid peroxidation rate, and inactivation of the protectant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GPX) in human sperm samples in the fresh state and after freeze-thaw, under aerobic and anerobic ..
  41. Preventing NIHL by enhancing glutathione pathways
    Richard Kopke; Fiscal Year: 2002
    ..by the ratio of reduced to oxidized glutathione and the affiliated enzymes glutathione reductase (GR) and glutathione peroxidase (GSH-Px) during the first 6 hours of noise exposure and that these changes will correlate with the level ..
  42. GENE MANIPULATION & H202 DEGRADATION IN THE OCULAR LENS
    Abraham Spector; Fiscal Year: 2001
    ..knockout mice for a number of the key enzymes that are involved in metabolizing H2O2 including catalase, glutathione peroxidase and glutathione reductase...
  43. CATALASE EFFECT ON ADRIAMYCIN CARDIOTOXICITY
    Y Kang; Fiscal Year: 1999
    ..The other important H202 detoxification enzyme glutathione peroxidase also exhibits lower activity in the heart than in the liver in most strains of mice...
  44. BIOLOGY OF GLUTATHIONE PEROXIDASE IN DOPAMINE NEURONS
    Gerald Cohen; Fiscal Year: 1993
    ..H202 is detoxified mainly by glutathione peroxidase (GSH-Px), which produces glutathione disulfide (GSSG)...
  45. GPx-3, Vascular Oxidant Stress, and Thrombosis
    Joseph Loscalzo; Fiscal Year: 2006
    ..Extracellular antioxidant enzymes, including extracellular superoxide dismutase and plasma glutathione peroxidase, limit the inactivation of endothelial nitric oxide by reactive oxygen species...
  46. Selenium, Glutathione Peroxidase-1, and Homocysteine-induced Cardiac Remodeling
    Jacob Joseph; Fiscal Year: 2009
    ..fibrosis, since a major cellular defense against oxidant stress is the selenium requiring enzyme glutathione peroxidase- 1 (GPx-1)...
  47. GLUTATHIONE PEROXIDASE ACTION AND INHIBITION
    PETER GETTINS; Fiscal Year: 1990
    ..essential nutrient for man, in large part through the crucial part it plays in the mechanism of action of glutathione peroxidase. This enzyme seems to serve an important role in protecting cell membranes from oxidative damage by ..
  48. MYOCARDIAL OXIDANT INJURY--KESHAN DISEASE AS A MODEL
    Raymond Burk; Fiscal Year: 1992
    ..Defenses against oxidant stress such as Se (acting through glutathione peroxidase), vitamin E, glutathione, and taurine would be expected to protect the myocardium...
  49. MODERATE ALCOHOL USE--CARDIOVASCULAR RISKS AND BENEFITS
    Thomas Giles; Fiscal Year: 2001
    ..Chronic ingestion of ETOH decreases antioxidants (e.g. NO, SO dismutase [SOD], glutathione peroxidase [GP]) and up regulates SO and hydrogen peroxide (H202)...
  50. DRUG METABOLISM IN THE EYE
    Hitoshi Shichi; Fiscal Year: 2001
    ..The ciliary body contains a novel selenium - independent glutathione peroxidase (GPX). The PI will determine its primary structure by molecular cloning...
  51. SELENIUM AND LUNG CANCER RISK
    Henry Thompson; Fiscal Year: 2004
    ..asbestos exposed individuals differ based on polymorphisms in manganese superoxide dismutase (Mn-SOD) and glutathione peroxidase (GPX) that have been associated with lung cancer risk, and assess whether the effects of selenium are ..
  52. NEONATAL HEME OXYGENASE EXPRESSION--EFFECTS OF HYPEROXIA
    Phyllis Dennery; Fiscal Year: 1999
    ..oxidant stress involves the increase in antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase in the latter 10% to 15% of gestation...
  53. Thioredoxin Peroxidases, Oxidative Stress, and Aging
    William Orr; Fiscal Year: 2006
    ..These ubiquitous species are thought to play a particularly critical role in insects, given the lack of glutathione peroxidase activity in these animals...
  54. HOMOCYST(E)INE, OXIDATIVE STRESS, AND NITRIC OXIDE
    Joseph Loscalzo; Fiscal Year: 2004
    ..We will also focus, in particular, on a critical enzymatic determinant of cellular redox state, cellular glutathione peroxidase. The expression of this selenocysteine-containing antioxidant enzyme is uniquely suppressed by homocyst(e)..
  55. INDICES OF OXYRADICAL METABOLISM IN SCHIZOPHRENIA
    SUKDEB MUKHERJEE; Fiscal Year: 1992
    ..erythrocyte activities of three critical enzymes of the antioxidant defence system (superoxide dismutase, glutathione peroxidase, and catalase) has been reported in schizophrenic patients...
  56. Chronic Alcohol and Liver Oxidative Stress
    Shannon Bailey; Fiscal Year: 2003
    ..reactive oxygen species production primarily within the mitochondrion, (2) decreases the activity of glutathione peroxidase-1 by irreversible oxidation of the active site selenocysteine residue or depressing liver selenium ..
  57. GENE EXPRESSION INDICES ASSOCIATED WITH CHEMORESISTANCE
    James Willey; Fiscal Year: 2001
    ..with chemoresistance revealed that glutathione transferase (GST) P1, Bax alpha, GADD45, ERCC3, and glutathione peroxidase, mGST genes are expressed at 100, 20, 10, 6, 5, and 4-fold higher levels respectively in H1435...
  58. OXIDATION OF MITOCHONDRIAL PROTEINS BY ETHANOL
    Shannon Bailey; Fiscal Year: 2000
    ..mitochondrion; (2) oxidatively modify and subsequently inactivate the selenium-dependent mitochondrial glutathione peroxidase enzyme; (3) depress hepatic mitochondrial protein synthesis by oxidative modification of the hepatic ..
  59. TOXICITY OF O2- AND H2O2
    Robert Lynch; Fiscal Year: 1993
    ..of O2- or H2O2 cultured cells will be enriched with superoxide dismutase, with catalase, and with glutathione peroxidase by transcription of transfected cDNAs...
  60. FUNCTIONS OF GLUTATHIONE PEROXIDASE IN THE BRAIN
    TRENT BUCKMAN; Fiscal Year: 1991
    ..discovery over 30 years ago, there has been increasing awareness of the central role played by the enzyme glutathione peroxidase (GPx) in the cellular antioxidant system...
  61. Genetics of Oxidative Stress in Ventricular Remodeling
    Vasan Ramachandran; Fiscal Year: 2003
    ..SNPs) have been identified in genes for several oxidant (antioxidants: superoxide dismutases, glutathione peroxidase, catalase, paraoxonase, heme oxygenase; prooxidants: myeloperoxidases, NAD(P)H oxidases) and nitrosant (..
  62. ENOS & THE RADICAL MECHANISM OF ANTITUMOR ANTHRACYCLINES
    Balaraman Kalyanaraman; Fiscal Year: 2006
    ..Specific Aims: First, we will investigate the effect of glutathione peroxidase (GPxI) overexpression on DOX-induced apoptosis in myocytes and endothelial cells...
  63. Regulation of Oxidative Stress Response by c-Abl and Arg
    Donald Kufe; Fiscal Year: 2007
    ..H202 is also converted to water by cytosolic and mitochondrial glutathione peroxidase in a reaction which oxidizes glutathione...
  64. Selenoprotein Targeting in Prostate Carcinogenesis
    David Menter; Fiscal Year: 2004
    ..g. glutathione peroxidase, GPx and thioredoxin reductase, TxR)...
  65. Hepatitis Virus, Alcohol Exposure and Oxidative Stress
    Manal Hassan; Fiscal Year: 2002
    ..Interestingly, a recent study has reported that HCV encodes a selenium (Se)-dependent antioxidant enzyme, glutathione peroxidase, GPx, and GPx may have a regulatory role in HCV replication...
  66. NUTRITIONAL REGULATION OF SELENOENZYMES AND PROTEINS
    ROGER SUNDE; Fiscal Year: 1992
    This application proposes to study the nutritional regulation of selenium- containing enzymes and proteins. Glutathione peroxidase (GPX) is the best characterized selenoenzyme present in animals, and thus this research will have a major ..